KEGG   ORTHOLOGY: K02546
Entry
K02546                      KO                                     

Name
mecI
Definition
BlaI family transcriptional regulator, methicillin resistance regulatory protein
Pathway
ko01501  beta-Lactam resistance
Module
M00625  Methicillin resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K02546  mecI; BlaI family transcriptional regulator, methicillin resistance regulatory protein
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K02546  mecI; BlaI family transcriptional regulator, methicillin resistance regulatory protein
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K02546  mecI; BlaI family transcriptional regulator, methicillin resistance regulatory protein
Transcription factors [BR:ko03000]
 Prokaryotic type
  Helix-turn-helix
   Other families
    K02546  mecI; BlaI family transcriptional regulator, methicillin resistance regulatory protein
Antimicrobial resistance genes [BR:ko01504]
 Gene sets
  beta-Lactam resistance modules
   Methicillin resistance
    K02546  mecI; BlaI family transcriptional regulator, methicillin resistance regulatory protein
Other DBs
COG: COG3682
Genes
SAU: SA0040(mecI)
SAV: SAV0043(mecI)
SAW: SAHV_0042(mecI)
SAH: SaurJH1_0031
SAJ: SaurJH9_0031
SAR: SAR0041(mecI)
SUK: SAA6008_00041(mecI)
SUT: SAT0131_00036
SUF: SARLGA251_00280(mecI)
SAUZ: SAZ172_0074(mecI)
SAUC: CA347_41(mecI)
SAUR: SABB_06008
SER: SERP2519(mecI)
MCL: MCCL_plsB0021(mecIm)
 » show all
Reference
  Authors
Sala C, Haouz A, Saul FA, Miras I, Rosenkrands I, Alzari PM, Cole ST
  Title
Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis.
  Journal
Mol Microbiol 71:1102-16 (2009)
DOI:10.1111/j.1365-2958.2008.06583.x
Reference
  Authors
Amoroso A, Boudet J, Berzigotti S, Duval V, Teller N, Mengin-Lecreulx D, Luxen A, Simorre JP, Joris B
  Title
A peptidoglycan fragment triggers beta-lactam resistance in Bacillus licheniformis.
  Journal
PLoS Pathog 8:e1002571 (2012)
DOI:10.1371/journal.ppat.1002571
Reference
  Authors
Blazquez B, Llarrull LI, Luque-Ortega JR, Alfonso C, Boggess B, Mobashery S
  Title
Regulation of the expression of the beta-lactam antibiotic-resistance determinants in methicillin-resistant Staphylococcus aureus (MRSA).
  Journal
Biochemistry 53:1548-50 (2014)
DOI:10.1021/bi500074w
  Sequence
[sau:SA0040]

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