KEGG   ORTHOLOGY: K02554
Entry
K02554                      KO                                     

Name
mhpD
Definition
2-keto-4-pentenoate hydratase [EC:4.2.1.80]
Pathway
ko00360  Phenylalanine metabolism
ko00362  Benzoate degradation
ko00621  Dioxin degradation
ko00622  Xylene degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Module
M00545  Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA
M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00360 Phenylalanine metabolism
    K02554  mhpD; 2-keto-4-pentenoate hydratase
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K02554  mhpD; 2-keto-4-pentenoate hydratase
   00622 Xylene degradation
    K02554  mhpD; 2-keto-4-pentenoate hydratase
   00621 Dioxin degradation
    K02554  mhpD; 2-keto-4-pentenoate hydratase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.80  2-oxopent-4-enoate hydratase
     K02554  mhpD; 2-keto-4-pentenoate hydratase
Other DBs
RN: R02601 R04781
COG: COG3971
GO: 0008684
Genes
OTW: 112243294
ECO: b0350(mhpD)
ECJ: JW0341(mhpD)
EBW: BWG_0239(mhpD)
ECOK: ECMDS42_0272(mhpD)
ECE: Z0448(mhpD)
ECS: ECs0405(mhpD)
ECF: ECH74115_0425(mhpD)
ETW: ECSP_0414(mhpD)
ELX: CDCO157_0393(mhpD)
EOI: ECO111_0386(mhpD)
EOJ: ECO26_0386(mhpD)
EOH: ECO103_0332(mhpD)
ECOO: ECRM13514_0496(mhpD)
ECOH: ECRM13516_0330(mhpD)
ESL: O3K_19725(mhpD)
ESO: O3O_05570(mhpD)
ESM: O3M_19710(mhpD)
ECK: EC55989_0357(mhpD)
EOK: G2583_0463(mhpD)
ELR: ECO55CA74_02225(mhpD)
ELH: ETEC_0406
ECW: EcE24377A_0374(mhpD)
ENA: ECNA114_0333(mhpD)
ECOS: EC958_0494
ECOA: APECO78_05270(mhpD)
ECX: EcHS_A0414(mhpD)
ECM: EcSMS35_0381(mhpD)
ECY: ECSE_0375
ECR: ECIAI1_0351(mhpD)
ECQ: ECED1_0378(mhpD)
EUM: ECUMN_0393(mhpD)
ECT: ECIAI39_0328(mhpD)
EOC: CE10_0318(mhpD)
EBR: ECB_00304(mhpD)
EBL: ECD_00304(mhpD)
EBE: B21_00308(mhpD)
EBD: ECBD_3307
ELO: EC042_0387(mhpD)
ESE: ECSF_0321
EKF: KO11_21830(mhpD)
EDJ: ECDH1ME8569_0337(mhpD)
ELW: ECW_m0428(mhpD)
ELL: WFL_02105(mhpD)
ELP: P12B_c0310(mhpD) P12B_c0368(mhpD)
ECOJ: P423_01840
ESZ: FEM44_16325(mhpD)
SSN: SSON_0329(mhpD)
KPN: KPN_02119(mhpD)
KPU: KP1_3214(mhpD)
KPP: A79E_2125
KPT: VK055_0342(mhpD)
KPO: KPN2242_13550(mhpD)
KPR: KPR_2664(mhpD)
KPJ: N559_2171
KPX: PMK1_04483(mhpD)
KPNU: LI86_10785
KPNK: BN49_3224(mhpD)
KVA: Kvar_2156
KPE: KPK_2204(mhpD)
KOX: KOX_22680(mhpD)
KOE: A225_3413
KOY: J415_14965(mhpD)
KLW: DA718_12100(mhpD)
CPOT: FOB25_06045(mhpD)
EBT: EBL_c20010(mhpD)
ROR: RORB6_04290(mhpD)
REE: electrica_02138(mhpD)
METY: MRY16398_44950(mhpD)
EBF: D782_1985
LRI: NCTC12151_03196(mhpD)
XCC: XCC0145(mhpD)
XCB: XC_0154
XCA: xcc-b100_0162(mhpD)
XCP: XCR_4394
XCV: XCV0146
XAX: XACM_0146
XAC: XAC0161(mhpD)
XCI: XCAW_00555(mhpD)
XFU: XFF4834R_chr00910(mhpD)
XPH: XppCFBP6546_11120(XppCFBP6546P_11120)
SACZ: AOT14_00290(mhpD)
PSUW: WQ53_07935
LAQ: GLA29479_2995(mhpD)
VEJ: VEJY3_06795(mhpD)
PCQ: PcP3B5_23480(amnF)
PPI: YSA_00251
PPUH: B479_25875(mhpD)
PSYR: N018_13880
PFS: PFLU_3080
PSTT: CH92_09500
PSV: PVLB_26057(mhpD)
PKC: PKB_3259(mhpd1) PKB_3607(mhpd3)
PSOS: POS17_2263
PSET: THL1_492
AVN: Avin_15110(mhpD)
ASJ: AsACE_CH00350(mhpD)
SFR: Sfri_2075
AMAL: I607_15790
AMAE: I876_16090
AMAO: I634_16035
AMAD: I636_15935
AMAI: I635_16575
AMAG: I533_15630
SALH: HMF8227_02738(mhpD)
CJA: CJA_3489
SAGA: M5M_18895
TKM: TK90_1671
HBE: BEI_3014
AXE: P40_10440
KKO: Kkor_0181
KGE: TQ33_0085
MPRI: MP3633_3152(mhpD)
OCE: GU3_08405
CHAE: CH06BL_23620(mhpD)
PSE: NH8B_0739
RSO: RSp0891
RIN: ACS15_4685(amnF)
REH: H16_B0884(mhpD3)
RME: Rmet_5207(mhpD)
BPSE: BDL_4378
BPSM: BBQ_5079
BPSU: BBN_4517
BPSD: BBX_6221
BPK: BBK_6019
BPSH: DR55_4234
BPSA: BBU_4970
BPSO: X996_4292
BUT: X994_6065
BTQ: BTQ_4606
BTJ: BTJ_5589
BTZ: BTL_4056
BTD: BTI_3605
BTV: BTHA_3825
BTHE: BTN_3611
BTHM: BTRA_4310
BTHA: DR62_3645
BTHL: BG87_4063
BOK: DM82_5228
BOC: BG90_5381
BVE: AK36_3500(mhpD) AK36_5145
BCN: Bcen_1441
BCJ: BCAM2124(mhpD)
BCEN: DM39_1993(mhpD) DM39_4968(mhpD) DM39_6931
BCEW: DM40_5002(mhpD) DM40_5268
BCEO: I35_6006(mhpD) I35_7684
BAM: Bamb_5715
BMU: Bmul_5380
BMK: DM80_5595
BMUL: NP80_3432(mhpD) NP80_3870(amnF) NP80_5444
BCED: DM42_7210
BDL: AK34_5279
BUB: BW23_5231
BTEI: WS51_26645
BSTG: WT74_26645
BGU: KS03_4526
BGO: BM43_4845
BUL: BW21_2673(mhpD) BW21_5605
LMIR: NCTC12852_00489(amnF)
CABA: SBC2_18860(mhpD) SBC2_61020(amnF)
BAV: BAV0598(bphE) BAV1871
BHZ: ACR54_00826(mhpD)
TAS: TASI_0989
TAT: KUM_0455
PUT: PT7_2813
ODI: ODI_R1483
AAV: Aave_3417
AJS: Ajs_1712
AAA: Acav_1814
VEI: Veis_3446
DAC: Daci_0212
RTA: Rta_11780
LIH: L63ED372_02447(mhpD)
HYB: Q5W_03225
HAR: HEAR0260
MMS: mma_0313(mhpD)
HSE: Hsero_2670(mhpD) Hsero_3350(mhpD)
CFU: CFU_0048 CFU_0712(mhpD)
AZO: azo1974(mhpD)
AOA: dqs_2129
MES: Meso_1076
AMIH: CO731_05521(mhpD)
PLA: Plav_0344
ARA: Arad_7264
BRS: S23_02150
OCA: OCAR_4168
VGO: GJW-30_1_04157(mhpD_2)
XAU: Xaut_0936
AZC: AZC_1955
BID: Bind_0623
MTUN: MTUNDRAET4_3894(mhpD)
PHL: KKY_3857
BVR: BVIR_1068
PLEO: OHA_1_00190(amnF)
MMED: Mame_00144(mhpD)
CCR: CC_1509
CAK: Caul_1767
CSE: Cseg_1571
PZU: PHZ_c2453(mhpD)
DSH: Dshi_0880
KVU: EIO_3285
LAQU: R2C4_19315
MALG: MALG_04108
RID: RIdsm_04103(tesE)
HBA: Hbal_2819
GAK: X907_1582
SAL: Sala_3044
SGI: SGRAN_1420(mhpD2)
SPHI: TS85_17615
SPHR: BSY17_3779
BLAS: BSY18_3297
GDI: GDI1198 GDI2732(mhpD)
GDJ: Gdia_1911
GXY: GLX_01150
GXL: H845_1353
KEU: S101446_00488(mhpD)
KSC: CD178_01494(mhpD_1) CD178_02580(mhpD_2) CD178_03513(mhpD)
AZL: AZL_b03340(mhpD) AZL_e00050(mhpD) AZL_e01850
TMO: TMO_1615(mhpD) TMO_b0121(todJ) TMO_b0505(mhpD)
TXI: TH3_13610
MAGQ: MGMAQ_0649
BCA: BCE_2155
BCX: BCA_2153
BCF: bcf_10205
BCER: BCK_24230
BTL: BALH_1842(pheD)
BMYC: DJ92_4636
BMQ: BMQ_3589
BMD: BMD_3574
BMEG: BG04_463
BAG: Bcoa_0268
BACO: OXB_2504
BFD: NCTC4823_00791(mhpD)
BKW: BkAM31D_08365(tesE)
GTN: GTNG_3153(nbaH)
PASA: BAOM_0497(mhpD) BAOM_4648(mhpD)
SEP: SE2356
SEPP: SEB_02355
SHH: ShL2_02366(amnF)
SCA: SCA_0040
SCAP: AYP1020_2148(mhpD)
MCL: MCCL_1828
ASOC: CB4_02450(tesE)
AAC: Aaci_1621
AAD: TC41_1517(mhpD)
BTS: Btus_0967
LRE: Lreu_1904
LRF: LAR_1786
LFE: LAF_0633
LFR: LC40_0435
LFF: LBFF_0654
LKI: LKI_02305
CARC: NY10_794
PTH: PTH_0481
TMR: Tmar_1784
SAY: TPY_0640(mhpD)
MTA: Moth_1777
MTHO: MOTHE_c17910(tesE)
MTHZ: MOTHA_c18740(tesE)
TOC: Toce_0376
STED: SPTER_36980(tesE)
LPIL: LIP_2167
MTU: Rv3536c(hsaE)
MTC: MT3640(mhpD)
MRA: MRA_3575(mhpD)
MTUR: CFBS_3752(mhpD)
MTD: UDA_3536c
MTUB: MT7199_3598(hasE)
MTUE: J114_18910
MTUH: I917_24815
MTUL: TBHG_03476
MTUT: HKBT1_3737(mhpD)
MTUU: HKBT2_3746(mhpD)
MTQ: HKBS1_3749(mhpD)
MBO: BQ2027_MB3566C(hsae)
MBB: BCG_3600c
MBT: JTY_3601
MBX: BCGT_3402
MAF: MAF_35480
MMIC: RN08_3912
MCQ: BN44_110028(mhpD)
MCV: BN43_90034(mhpD)
MCX: BN42_90031(mhpD)
MCZ: BN45_100031(mhpD)
MPA: MAP_0531
MAO: MAP4_3336
MAVI: RC58_16545
MAVU: RE97_16580
MAV: MAV_0625
MID: MIP_00989
MYO: OEM_05420
MIR: OCQ_05500
MLP: MLM_0770
MUL: MUL_4097
MMI: MMAR_5023
MMM: W7S_02620
MHAD: B586_04630
MSHG: MSG_03540 MSG_04521(hsaE)
MXE: MYXE_06130(hsaE)
MSG: MSMEI_5780(mhpD)
MGI: Mflv_1520
MPHL: MPHLCCUG_00565(tesE)
MVQ: MYVA_5131
MTHN: 4412656_04052(mhpD)
MHAS: MHAS_03729(tesE) MHAS_04023(mhpD)
MAB: MAB_0624
MABB: MASS_0594
MCHE: BB28_02990
MSTE: MSTE_00583
MSAL: DSM43276_00542(tesE)
MTER: 4434518_03653(mhpD)
MKR: MKOR_35780(hsaE)
CDR: CDHC03_1947(mhpD)
CMV: CMUST_15060(mhpD)
CAMG: CAMM_02605
CEE: CENDO_02775(mhpD)
NFR: ERS450000_00751(mhpD_1) ERS450000_01022(mhpD_2) ERS450000_03772(mhpD_4)
NCY: NOCYR_0493(mhpD)
NSR: NS506_01254(bphH)
NAD: NCTC11293_01235(mhpD_1) NCTC11293_04253(mhpD_2) NCTC11293_04413(mhpD_3)
REQ: REQ_42080
RRT: 4535765_04743(cmtF)
RCR: NCTC10994_02786(cmtF)
GOR: KTR9_0810(hsaE)
GRU: GCWB2_04115(tesE1) GCWB2_17420(mhpD)
GOM: D7316_02539(mhpD) D7316_02563(tesE)
TPR: Tpau_3798
SCB: SCAB_15211(bphE) SCAB_2091(mhpD)
SBH: SBI_01533
SDV: BN159_1390(mhpD)
SALS: SLNWT_6913
SALU: DC74_7438
SALL: SAZ_38395
SLAU: SLA_6901
SLX: SLAV_27395(mhpD)
SGE: DWG14_08255(mhpD)
KSK: KSE_23730
ARX: ARZXY2_4005(mhpD)
BLIN: BLSMQ_0563
NDK: I601_0559(mhpD)
SRO: Sros_9115
NML: Namu_4085
AMD: AMED_8623
AMN: RAM_44255
AMM: AMES_8492
AMZ: B737_8493
AOI: AORI_7402(mhpD)
AMYY: YIM_27910(mhpD)
AORI: SD37_03450
PSEA: WY02_18910
PSEE: FRP1_23850
PAUT: Pdca_38550
KAL: KALB_5138
MIL: ML5_3355
AFS: AFR_23755
PFLA: Pflav_027550(mhpD)
AFO: Afer_1182
TER: Tery_1742
RCA: Rcas_2405
CAU: Caur_1357
CAG: Cagg_2039
TRO: trd_1387
TTJ: TTHB239
CAA: Caka_0966
GES: VT84_10640(tesE)
PBOR: BSF38_00915(mhpD)
ACA: ACP_3402
ABAS: ACPOL_1425
AALG: AREALGSMS7_03659(amnF)
STO: STK_01180
 » show all
Reference
  Authors
Diaz E, Ferrandez A, Prieto MA, Garcia JL.
  Title
Biodegradation of aromatic compounds by Escherichia coli.
  Journal
Microbiol Mol Biol Rev 65:523-69, table of contents (2001)
DOI:10.1128/MMBR.65.4.523-569.2001
Reference
PMID:9098055
  Authors
Ferrandez A, Garcia JL, Diaz E.
  Title
Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12.
  Journal
J Bacteriol 179:2573-81 (1997)
DOI:10.1128/JB.179.8.2573-2581.1997
  Sequence
[eco:b0350]

KEGG   ORTHOLOGY: K18364
Entry
K18364                      KO                                     

Name
bphH, xylJ, tesE
Definition
2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase [EC:4.2.1.80 4.2.1.132]
Pathway
ko00362  Benzoate degradation
ko00621  Dioxin degradation
ko00622  Xylene degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Module
M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K18364  bphH, xylJ, tesE; 2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase
   00622 Xylene degradation
    K18364  bphH, xylJ, tesE; 2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase
   00621 Dioxin degradation
    K18364  bphH, xylJ, tesE; 2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.80  2-oxopent-4-enoate hydratase
     K18364  bphH, xylJ, tesE; 2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase
    4.2.1.132  2-hydroxyhexa-2,4-dienoate hydratase
     K18364  bphH, xylJ, tesE; 2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase
Other DBs
RN: R02601 R05864
GO: 0008684 0034856
Genes
PGE: LG71_12240
PLUM: A4R40_11035
PSD: DSC_09160 DSC_09365
RGL: CS053_01760
RBD: ALSL_1080
VAF: D1115_22450
PRE: PCA10_13820 PCA10_p0350(carD)
PPSE: BN5_3620(nahL)
PCQ: PcP3B5_25700(tesE_1)
PPI: ND086(nahL)
PPUT: L483_14065
PPUN: PP4_27260
PPUU: PputUW4_01660(mhpD)
PKC: PKB_4239(xylJ)
PSET: THL1_1433
AVN: Avin_08670(xylJ) Avin_30610(lapE)
AVL: AvCA_08670(xylJ) AvCA_30610(lapE)
AVD: AvCA6_08670(xylJ) AvCA6_30610(lapE)
SPL: Spea_2118
SHL: Shal_2090
SWD: Swoo_1392
PHA: PSHAa2141(xylJ)
PTN: PTRA_a2594(bphH)
PNG: PNIG_a2788(bphH)
MARJ: MARI_05440(xylJ)
CYQ: Q91_0508
CYY: CPC19_10515(dmpE)
BLEP: AL038_01300(dmpE)
AEH: Mlg_2460
APAC: S7S_06990
NCU: F0U83_03045(dmpE)
NIK: F5I99_10105(dmpE) F5I99_10520(dmpE)
TBN: TBH_C0928
GPB: HDN1F_27090(tesE)
NZO: SAMEA4504057_0450(xylJ)
RPI: Rpic_4620
RIN: ACS15_4354(dmpE)
REH: H16_B0548(mhpD1) H16_B0597(bphH)
CNC: CNE_2c04940(mhpD) CNE_2c05420(xylJ2) CNE_BB1p11990(xylJ1) CNE_BB1p13280(xylJ2)
RME: Rmet_1321(xylJ)
CTI: RALTA_B0401(mhpD)
COX: E0W60_07775(dmpE) E0W60_08025(dmpE)
BCJ: BCAM1613
BCEN: DM39_3383(dmpE) DM39_4834(dmpE)
BCEO: I35_5473
BCED: DM42_4993(dmpE) DM42_6345(dmpE)
BMEC: WJ16_26790
BXE: Bxe_C1189(bphH)
BXB: DR64_8616(dmpE)
BFN: OI25_4589(dmpE)
PARB: CJU94_37870(dmpE) CJU94_38115(dmpE)
PMEG: FNZ07_21165(dmpE)
CABA: SBC2_49020(tesE)
LIMN: HKT17_03820(dmpE)
KGY: EHF36_01675(dmpE) EHF36_04885(dmpE)
PNA: Pnap_4144
AJS: Ajs_0222
VEI: Veis_2785
VBO: CKY39_28505(dmpE)
CTES: O987_07740
COF: FOZ74_08305(dmpE)
HPSE: HPF_01870(xylJ)
HYN: F9K07_02750(dmpE)
SIMP: C6571_13615(dmpE)
MELA: C6568_07860(dmpE)
METP: C1M51_06460(dmpE) C1M51_15400(dmpE)
JAG: GJA_236(xylJ)
JAJ: EKL02_01815(dmpE)
LCH: Lcho_3343
DEY: HYN24_14130(dmpE) HYN24_14215(dmpE)
AZO: azo1853(lapE) azo2434(nahL)
AZR: CJ010_12250(dmpE) CJ010_15220(dmpE)
AZQ: G3580_00535(dmpE) G3580_08270(dmpE)
THK: CCZ27_10770(dmpE) CCZ27_16275(dmpE)
AAQI: AAQM_0980(dmpE)
ACIB: ACBT_0261(dmpE)
AFC: AFAEC_1846(dmpE)
ARC: ABLL_2444
NAR: Saro_3689
SGI: SGRAN_1581(mhpD)
SPHM: G432_01985
SSAN: NX02_12710
SPKC: KC8_03560
SJP: SJA_C1-11870(mhpD)
SPHB: EP837_03394(bphH)
SINB: SIDU_08330
SFLA: SPHFLASMR4Y_02368(tesE)
HTL: HPTL_0050
CWO: Cwoe_3997
AG: BAC67694(tesE)
 » show all
Reference
  Authors
Horinouchi M, Hayashi T, Koshino H, Kurita T, Kudo T
  Title
Identification of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes involved in testosterone degradation in Comamonas testosteroni TA441.
  Journal
Appl Environ Microbiol 71:5275-81 (2005)
DOI:10.1128/AEM.71.9.5275-5281.2005
  Sequence

KEGG   ENZYME: 4.2.1.80
Entry
EC 4.2.1.80                 Enzyme                                 

Name
2-oxopent-4-enoate hydratase;
2-keto-4-pentenoate hydratase;
OEH;
2-keto-4-pentenoate (vinylpyruvate)hydratase;
4-hydroxy-2-oxopentanoate hydro-lyase;
4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming);
mhpD (gene name);
ahdF (gene name);
todG (gene name);
cmtF (gene name);
xylJ (gene name);
cnbE (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
(S)-4-hydroxy-2-oxopentanoate hydro-lyase ((2Z)-2-hydroxypenta-2,4-dienoate-forming)
Reaction(IUBMB)
(S)-4-hydroxy-2-oxopentanoate = (2Z)-2-hydroxypenta-2,4-dienoate + H2O [RN:R02601]
Reaction(KEGG)
R02601;
(other) R04781 R05297
Substrate
(S)-4-hydroxy-2-oxopentanoate
Product
(2Z)-2-hydroxypenta-2,4-dienoate;
H2O [CPD:C00001]
Comment
The enzyme is involved in the catechol meta-cleavage pathway, a major mechanism for degradation of aromatic compounds. Also acts, more slowly, on cis-2-oxohex-4-enoate, but not on the trans-isomer. The enzyme was named when it was thought that the substrate is 2-oxopent-4-enoate. However, it was later found that the actual substrate is its tautomer (2Z)-2-hydroxypenta-2,4-dienoate. In some organisms the enzyme forms a complex with EC 4.1.1.77, 2-oxo-3-hexenedioate decarboxylase (previously named 4-oxalocrotonate decarboxylase).
History
EC 4.2.1.80 created 1984
Pathway
ec00360  Phenylalanine metabolism
ec00362  Benzoate degradation
ec00621  Dioxin degradation
ec00622  Xylene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K02554  2-keto-4-pentenoate hydratase
K18364  2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase
Genes
OTW: 112243294
ECO: b0350(mhpD)
ECJ: JW0341(mhpD)
EBW: BWG_0239(mhpD)
ECOK: ECMDS42_0272(mhpD)
ECE: Z0448(mhpD)
ECS: ECs0405(mhpD)
ECF: ECH74115_0425(mhpD)
ETW: ECSP_0414(mhpD)
ELX: CDCO157_0393(mhpD)
EOI: ECO111_0386(mhpD)
EOJ: ECO26_0386(mhpD)
EOH: ECO103_0332(mhpD)
ECOO: ECRM13514_0496(mhpD)
ECOH: ECRM13516_0330(mhpD)
ESL: O3K_19725(mhpD)
ESO: O3O_05570(mhpD)
ESM: O3M_19710(mhpD)
ECK: EC55989_0357(mhpD)
EOK: G2583_0463(mhpD)
ELR: ECO55CA74_02225(mhpD)
ELH: ETEC_0406
ECW: EcE24377A_0374(mhpD)
ENA: ECNA114_0333(mhpD)
ECOS: EC958_0494
ECOA: APECO78_05270(mhpD)
ECX: EcHS_A0414(mhpD)
ECM: EcSMS35_0381(mhpD)
ECY: ECSE_0375
ECR: ECIAI1_0351(mhpD)
ECQ: ECED1_0378(mhpD)
EUM: ECUMN_0393(mhpD)
ECT: ECIAI39_0328(mhpD)
EOC: CE10_0318(mhpD)
EBR: ECB_00304(mhpD)
EBL: ECD_00304(mhpD)
EBE: B21_00308(mhpD)
EBD: ECBD_3307
ELO: EC042_0387(mhpD)
ESE: ECSF_0321
EKF: KO11_21830(mhpD)
EDJ: ECDH1ME8569_0337(mhpD)
ELW: ECW_m0428(mhpD)
ELL: WFL_02105(mhpD)
ELP: P12B_c0310(mhpD) P12B_c0368(mhpD)
ECOJ: P423_01840
ESZ: FEM44_16325(mhpD)
SSN: SSON_0329(mhpD)
KPN: KPN_02119(mhpD)
KPU: KP1_3214(mhpD)
KPP: A79E_2125
KPT: VK055_0342(mhpD)
KPO: KPN2242_13550(mhpD)
KPR: KPR_2664(mhpD)
KPJ: N559_2171
KPX: PMK1_04483(mhpD)
KPNU: LI86_10785
KPNK: BN49_3224(mhpD)
KVA: Kvar_2156
KPE: KPK_2204(mhpD)
KOX: KOX_22680(mhpD)
KOE: A225_3413
KOY: J415_14965(mhpD)
KLW: DA718_12100(mhpD)
CPOT: FOB25_06045(mhpD)
EBT: EBL_c20010(mhpD)
ROR: RORB6_04290(mhpD)
REE: electrica_02138(mhpD)
METY: MRY16398_44950(mhpD)
EBF: D782_1985
LRI: NCTC12151_03196(mhpD)
XCC: XCC0145(mhpD)
XCB: XC_0154
XCA: xcc-b100_0162(mhpD)
XCP: XCR_4394
XCV: XCV0146
XAX: XACM_0146
XAC: XAC0161(mhpD)
XCI: XCAW_00555(mhpD)
XFU: XFF4834R_chr00910(mhpD)
XPH: XppCFBP6546_11120(XppCFBP6546P_11120)
SACZ: AOT14_00290(mhpD)
PSUW: WQ53_07935
LAQ: GLA29479_2995(mhpD)
RBD: ALSL_1080
VEJ: VEJY3_06795(mhpD)
PPSE: BN5_3620(nahL)
PCQ: PcP3B5_23480(amnF) PcP3B5_25700(tesE_1)
PPI: ND086(nahL) YSA_00251
PPUH: B479_25875(mhpD)
PPUT: L483_14065
PPUN: PP4_27260
PSYR: N018_13880
PFS: PFLU_3080
PSTT: CH92_09500
PPUU: PputUW4_01660(mhpD)
PSV: PVLB_26057(mhpD)
PKC: PKB_3259(mhpd1) PKB_3607(mhpd3) PKB_4239(xylJ)
PSOS: POS17_2263
AVN: Avin_08670(xylJ) Avin_15110(mhpD) Avin_30610(lapE)
AVL: AvCA_08670(xylJ) AvCA_15110(mhpD) AvCA_30610(lapE) AvCA_42150
ASJ: AsACE_CH00350(mhpD)
SFR: Sfri_2075
SPL: Spea_2118
SHL: Shal_2090
SWD: Swoo_1392
PHA: PSHAa2141(xylJ)
PNG: PNIG_a2788(bphH)
MARJ: MARI_05440(xylJ)
AMAL: I607_15790
AMAE: I876_16090
AMAO: I634_16035
AMAD: I636_15935
AMAI: I635_16575
AMAG: I533_15630
SALH: HMF8227_02738(mhpD)
CJA: CJA_3489
SAGA: M5M_18895
CYQ: Q91_0508
BLEP: AL038_01300(dmpE)
AEH: Mlg_2460
TKM: TK90_1671
HBE: BEI_3014
APAC: S7S_06990
AXE: P40_10440
KKO: Kkor_0181
KGE: TQ33_0085
MPRI: MP3633_3152(mhpD)
NCU: F0U83_03045(dmpE)
NIK: F5I99_10105(dmpE) F5I99_10520(dmpE)
OCE: GU3_08405
TBN: TBH_C0928
GPB: HDN1F_27090(tesE)
NZO: SAMEA4504057_0450(xylJ)
CHAE: CH06BL_23620(mhpD)
PSE: NH8B_0739
RSO: RSp0891
RPI: Rpic_4620
RIN: ACS15_4354(dmpE) ACS15_4685(amnF)
REH: H16_B0548(mhpD1) H16_B0597(bphH) H16_B0884(mhpD3)
RME: Rmet_1321(xylJ) Rmet_5207(mhpD)
BPSE: BDL_4378
BPSM: BBQ_5079
BPSU: BBN_4517
BPSD: BBX_6221
BPK: BBK_6019
BPSH: DR55_4234
BPSA: BBU_4970
BPSO: X996_4292
BUT: X994_6065
BTQ: BTQ_4606
BTJ: BTJ_5589
BTZ: BTL_4056
BTD: BTI_3605
BTV: BTHA_3825
BTHE: BTN_3611
BTHM: BTRA_4310
BTHA: DR62_3645
BTHL: BG87_4063
BOK: DM82_5228
BOC: BG90_5381
BVE: AK36_3500(mhpD) AK36_5145
BCN: Bcen_1441
BCJ: BCAM1613 BCAM2124(mhpD)
BCEN: DM39_1993(mhpD) DM39_3383(dmpE) DM39_4834(dmpE) DM39_4968(mhpD) DM39_6931
BCEW: DM40_5002(mhpD) DM40_5268
BAM: Bamb_5715
BMU: Bmul_5380
BMK: DM80_5595
BMUL: NP80_3432(mhpD) NP80_3870(amnF) NP80_5444
BCED: DM42_4993(dmpE) DM42_6345(dmpE) DM42_7210
BDL: AK34_5279
BUB: BW23_5231
BSTG: WT74_26645
BGU: KS03_4526
BGO: BM43_4845
BUL: BW21_2673(mhpD) BW21_5605
LMIR: NCTC12852_00489(amnF)
CABA: SBC2_18860(mhpD) SBC2_49020(tesE) SBC2_61020(amnF)
LIMN: HKT17_03820(dmpE)
BAV: BAV0598(bphE) BAV1871
BHZ: ACR54_00826(mhpD)
TAS: TASI_0989
TAT: KUM_0455
PUT: PT7_2813
ODI: ODI_R1483
PNA: Pnap_4144
AAV: Aave_3417
AAA: Acav_1814
DAC: Daci_0212
RTA: Rta_11780
LIH: L63ED372_02447(mhpD)
HYB: Q5W_03225
HPSE: HPF_01870(xylJ)
HAR: HEAR0260
MMS: mma_0313(mhpD)
JAG: GJA_236(xylJ)
HSE: Hsero_2670(mhpD) Hsero_3350(mhpD)
CFU: CFU_0048 CFU_0712(mhpD)
LCH: Lcho_3343
DEY: HYN24_14130(dmpE) HYN24_14215(dmpE)
AZO: azo1853(lapE) azo1974(mhpD) azo2434(nahL)
AZQ: G3580_00535(dmpE) G3580_08270(dmpE)
THK: CCZ27_10770(dmpE) CCZ27_16275(dmpE)
AAQI: AAQM_0980(dmpE)
ACIB: ACBT_0261(dmpE)
AFC: AFAEC_1846(dmpE)
ARC: ABLL_2444
MES: Meso_1076
AMIH: CO731_05521(mhpD)
PLA: Plav_0344
ARA: Arad_7264
BRS: S23_02150
OCA: OCAR_4168
VGO: GJW-30_1_04157(mhpD_2)
XAU: Xaut_0936
AZC: AZC_1955
BID: Bind_0623
MTUN: MTUNDRAET4_3894(mhpD)
PHL: KKY_3857
BVR: BVIR_1068
PLEO: OHA_1_00190(amnF)
MMED: Mame_00144(mhpD)
CCR: CC_1509
CAK: Caul_1767
CSE: Cseg_1571
PZU: PHZ_c2453(mhpD)
DSH: Dshi_0880
KVU: EIO_3285
LAQU: R2C4_19315
MALG: MALG_04108
RID: RIdsm_04103(tesE)
HBA: Hbal_2819
GAK: X907_1582
SAL: Sala_3044
SGI: SGRAN_1420(mhpD2) SGRAN_1581(mhpD)
SPHM: G432_01985
SPHI: TS85_17615
SPKC: KC8_03560
SJP: SJA_C1-11870(mhpD)
SPHB: EP837_03394(bphH)
SPHR: BSY17_3779
SINB: SIDU_08330
SFLA: SPHFLASMR4Y_02368(tesE)
BLAS: BSY18_3297
GDI: GDI1198 GDI2732(mhpD)
GDJ: Gdia_1911
GXY: GLX_01150
GXL: H845_1353
KEU: S101446_00488(mhpD)
KSC: CD178_01494(mhpD_1) CD178_02580(mhpD_2) CD178_03513(mhpD)
AZL: AZL_b03340(mhpD) AZL_e00050(mhpD) AZL_e01850
TMO: TMO_1615(mhpD) TMO_b0121(todJ) TMO_b0505(mhpD)
TXI: TH3_13610
MAGQ: MGMAQ_0649
HTL: HPTL_0050
BCA: BCE_2155
BCX: BCA_2153
BCF: bcf_10205
BCER: BCK_24230
BTL: BALH_1842(pheD)
BMYC: DJ92_4636
BMQ: BMQ_3589
BMD: BMD_3574
BMEG: BG04_463
BAG: Bcoa_0268
BACO: OXB_2504
BFD: NCTC4823_00791(mhpD)
BKW: BkAM31D_08365(tesE)
GTN: GTNG_3153(nbaH)
PASA: BAOM_0497(mhpD) BAOM_4648(mhpD)
SEP: SE2356
SEPP: SEB_02355
SHH: ShL2_02366(amnF)
SCA: SCA_0040
SCAP: AYP1020_2148(mhpD)
MCL: MCCL_1828
ASOC: CB4_02450(tesE)
AAC: Aaci_1621
AAD: TC41_1517(mhpD)
BTS: Btus_0967
LRE: Lreu_1904
LRF: LAR_1786
LFE: LAF_0633
LFR: LC40_0435
LFF: LBFF_0654
LKI: LKI_02305
CARC: NY10_794
PTH: PTH_0481
TMR: Tmar_1784
SAY: TPY_0640(mhpD)
MTA: Moth_1777
MTHO: MOTHE_c17910(tesE)
MTHZ: MOTHA_c18740(tesE)
TOC: Toce_0376
STED: SPTER_36980(tesE)
LPIL: LIP_2167
MTU: Rv3536c(hsaE)
MTC: MT3640(mhpD)
MRA: MRA_3575(mhpD)
MTUR: CFBS_3752(mhpD)
MTD: UDA_3536c
MTUB: MT7199_3598(hasE)
MTUE: J114_18910
MTUH: I917_24815
MTUL: TBHG_03476
MTUT: HKBT1_3737(mhpD)
MTUU: HKBT2_3746(mhpD)
MTQ: HKBS1_3749(mhpD)
MBO: BQ2027_MB3566C(hsae)
MBB: BCG_3600c
MBT: JTY_3601
MBX: BCGT_3402
MAF: MAF_35480
MMIC: RN08_3912
MCQ: BN44_110028(mhpD)
MCV: BN43_90034(mhpD)
MCX: BN42_90031(mhpD)
MCZ: BN45_100031(mhpD)
MPA: MAP_0531
MAO: MAP4_3336
MAVI: RC58_16545
MAVU: RE97_16580
MAV: MAV_0625
MID: MIP_00989
MYO: OEM_05420
MIR: OCQ_05500
MLP: MLM_0770
MUL: MUL_4097
MMI: MMAR_5023
MMM: W7S_02620
MHAD: B586_04630
MSHG: MSG_03540 MSG_04521(hsaE)
MXE: MYXE_06130(hsaE)
MSG: MSMEI_5780(mhpD)
MGI: Mflv_1520
MPHL: MPHLCCUG_00565(tesE)
MVQ: MYVA_5131
MTHN: 4412656_04052(mhpD)
MHAS: MHAS_03729(tesE) MHAS_04023(mhpD)
MAB: MAB_0624
MABB: MASS_0594
MCHE: BB28_02990
MSTE: MSTE_00583
MSAL: DSM43276_00542(tesE)
MTER: 4434518_03653(mhpD)
MKR: MKOR_35780(hsaE)
CDR: CDHC03_1947(mhpD)
CMV: CMUST_15060(mhpD)
CAMG: CAMM_02605
CEE: CENDO_02775(mhpD)
NFR: ERS450000_00751(mhpD_1) ERS450000_01022(mhpD_2) ERS450000_03772(mhpD_4)
NCY: NOCYR_0493(mhpD)
NSR: NS506_01254(bphH)
NAD: NCTC11293_01235(mhpD_1) NCTC11293_04253(mhpD_2) NCTC11293_04413(mhpD_3)
REQ: REQ_42080
RRT: 4535765_04743(cmtF)
RCR: NCTC10994_02786(cmtF)
GOR: KTR9_0810(hsaE)
GRU: GCWB2_04115(tesE1) GCWB2_17420(mhpD)
GOM: D7316_02539(mhpD) D7316_02563(tesE)
TPR: Tpau_3798
SCB: SCAB_15211(bphE) SCAB_2091(mhpD)
SBH: SBI_01533
SDV: BN159_1390(mhpD)
SALS: SLNWT_6913
SALU: DC74_7438
SALL: SAZ_38395
SLAU: SLA_6901
SLX: SLAV_27395(mhpD)
SGE: DWG14_08255(mhpD)
KSK: KSE_23730
ARX: ARZXY2_4005(mhpD)
BLIN: BLSMQ_0563
NDK: I601_0559(mhpD)
SRO: Sros_9115
NML: Namu_4085
AMD: AMED_8623
AMN: RAM_44255
AMM: AMES_8492
AMZ: B737_8493
AOI: AORI_7402(mhpD)
AMYY: YIM_27910(mhpD)
AORI: SD37_03450
PSEA: WY02_18910
PSEE: FRP1_23850
PAUT: Pdca_38550
KAL: KALB_5138
MIL: ML5_3355
AFS: AFR_23755
PFLA: Pflav_027550(mhpD)
AFO: Afer_1182
TER: Tery_1742
RCA: Rcas_2405
CAU: Caur_1357
CAG: Cagg_2039
TRO: trd_1387
TTJ: TTHB239
CAA: Caka_0966
GES: VT84_10640(tesE)
PBOR: BSF38_00915(mhpD)
ACA: ACP_3402
ABAS: ACPOL_1425
AALG: AREALGSMS7_03659(amnF)
STO: STK_01180
 » show all
Reference
1  [PMID:7287632]
  Authors
Kunz DA, Ribbons DW, Chapman PJ.
  Title
Metabolism of allylglycine and cis-crotylglycine by Pseudomonas putida (arvilla) mt-2 harboring a TOL plasmid.
  Journal
J Bacteriol 148:72-82 (1981)
DOI:10.1128/JB.148.1.72-82.1981
Reference
2  [PMID:2681159]
  Authors
Harayama S, Rekik M, Ngai KL, Ornston LN
  Title
Physically associated enzymes produce and metabolize 2-hydroxy-2,4-dienoate, a chemically unstable intermediate formed in catechol metabolism via meta cleavage  in Pseudomonas putida.
  Journal
J Bacteriol 171:6251-8 (1989)
DOI:10.1128/JB.171.11.6251-6258.1989
Reference
3  [PMID:9492273]
  Authors
Pollard JR, Bugg TD
  Title
Purification, characterisation and reaction mechanism of monofunctional 2-hydroxypentadienoic acid hydratase from Escherichia coli.
  Journal
Eur J Biochem 251:98-106 (1998)
DOI:10.1046/j.1432-1327.1998.2510098.x
  Sequence
[eco:b0350]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.80
IUBMB Enzyme Nomenclature: 4.2.1.80
ExPASy - ENZYME nomenclature database: 4.2.1.80
UM-BBD (Biocatalysis/Biodegradation Database): 4.2.1.80
BRENDA, the Enzyme Database: 4.2.1.80
CAS: 64427-80-1

KEGG   REACTION: R02601
Entry
R02601                      Reaction                               

Name
4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming)
Definition
2-Hydroxy-2,4-pentadienoate + H2O <=> 4-Hydroxy-2-oxopentanoate
Equation
Reaction class
RC00750  C00596_C03589
Enzyme
Pathway
rn00360  Phenylalanine metabolism
rn00362  Benzoate degradation
rn00621  Dioxin degradation
rn00622  Xylene degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00545  Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA
M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA
Orthology
K02554  2-keto-4-pentenoate hydratase [EC:4.2.1.80]
K18364  2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase [EC:4.2.1.80 4.2.1.132]
Other DBs
RHEA: 22583

DBGET integrated database retrieval system