KEGG   ORTHOLOGY: K02620
Entry
K02620                      KO                                     
Symbol
TCF7, TCF-1
Name
transcription factor 7
Pathway
map04310  Wnt signaling pathway
map04390  Hippo signaling pathway
map04520  Adherens junction
map04550  Signaling pathways regulating pluripotency of stem cells
map04916  Melanogenesis
map04934  Cushing syndrome
map04936  Alcoholic liver disease
map05132  Salmonella infection
map05165  Human papillomavirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05200  Pathways in cancer
map05210  Colorectal cancer
map05213  Endometrial cancer
map05215  Prostate cancer
map05216  Thyroid cancer
map05217  Basal cell carcinoma
map05221  Acute myeloid leukemia
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05412  Arrhythmogenic right ventricular cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K02620  TCF7, TCF-1; transcription factor 7
   04390 Hippo signaling pathway
    K02620  TCF7, TCF-1; transcription factor 7
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K02620  TCF7, TCF-1; transcription factor 7
   04550 Signaling pathways regulating pluripotency of stem cells
    K02620  TCF7, TCF-1; transcription factor 7
 09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    K02620  TCF7, TCF-1; transcription factor 7
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02620  TCF7, TCF-1; transcription factor 7
  09162 Cancer: specific types
   05210 Colorectal cancer
    K02620  TCF7, TCF-1; transcription factor 7
   05225 Hepatocellular carcinoma
    K02620  TCF7, TCF-1; transcription factor 7
   05226 Gastric cancer
    K02620  TCF7, TCF-1; transcription factor 7
   05216 Thyroid cancer
    K02620  TCF7, TCF-1; transcription factor 7
   05221 Acute myeloid leukemia
    K02620  TCF7, TCF-1; transcription factor 7
   05217 Basal cell carcinoma
    K02620  TCF7, TCF-1; transcription factor 7
   05215 Prostate cancer
    K02620  TCF7, TCF-1; transcription factor 7
   05213 Endometrial cancer
    K02620  TCF7, TCF-1; transcription factor 7
   05224 Breast cancer
    K02620  TCF7, TCF-1; transcription factor 7
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K02620  TCF7, TCF-1; transcription factor 7
   05165 Human papillomavirus infection
    K02620  TCF7, TCF-1; transcription factor 7
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K02620  TCF7, TCF-1; transcription factor 7
  09166 Cardiovascular disease
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K02620  TCF7, TCF-1; transcription factor 7
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K02620  TCF7, TCF-1; transcription factor 7
   04934 Cushing syndrome
    K02620  TCF7, TCF-1; transcription factor 7
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K02620  TCF7, TCF-1; transcription factor 7
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    K02620  TCF7, TCF-1; transcription factor 7
Genes
HSA: 6932(TCF7)
PTR: 745839(TCF7)
PPS: 100980839(TCF7)
GGO: 101149731(TCF7)
PON: 100461234(TCF7)
NLE: 100595737(TCF7)
MCC: 710234(TCF7)
MCF: 102142248(TCF7)
MTHB: 126955989
CSAB: 103244543(TCF7)
CATY: 105599768(TCF7)
PANU: 101024089(TCF7)
TGE: 112626303(TCF7)
RRO: 104659811(TCF7)
RBB: 108529562(TCF7)
TFN: 117065864(TCF7)
PTEH: 111529175(TCF7)
CANG: 105518212(TCF7)
CJC: 100399154(TCF7)
SBQ: 101029076(TCF7)
CSYR: 103268315(TCF7)
MMUR: 105869975(TCF7)
LCAT: 123637773(TCF7)
PCOQ: 105816027(TCF7)
OGA: 100947392(TCF7)
MMU: 21414(Tcf7)
MCAL: 110304948(Tcf7)
MPAH: 110332085(Tcf7)
RNO: 363595(Tcf7)
MCOC: 116077224(Tcf7)
MUN: 110549622(Tcf7)
CGE: 100757390(Tcf7)
MAUA: 101823261(Tcf7)
PLEU: 114683055(Tcf7)
MORG: 121456269(Tcf7)
MFOT: 126510979
AAMP: 119812304(Tcf7)
NGI: 103729786(Tcf7)
HGL: 101707882(Tcf7)
CPOC: 100712802(Tcf7)
CCAN: 109689465(Tcf7)
DORD: 105996789(Tcf7)
DSP: 122115432(Tcf7)
NCAR: 124986637
OCU: 100339216
OPI: 101526730(TCF7)
TUP: 102484318(TCF7)
GVR: 103592399(TCF7)
CFA: 481506(TCF7)
CLUD: 112650538(TCF7)
VVP: 112917059(TCF7)
VLG: 121495797(TCF7)
AML: 100476528(TCF7)
UMR: 103663815(TCF7)
UAH: 113261735(TCF7)
UAR: 123790349(TCF7)
ELK: 111141244
LLV: 125099902
MPUF: 101678117(TCF7)
ORO: 101376237(TCF7)
EJU: 114209512(TCF7)
ZCA: 113928407(TCF7)
MLX: 118016638(TCF7)
NSU: 110590995(TCF7)
LWW: 102733939(TCF7)
FCA: 101098768(TCF7)
PYU: 121010702(TCF7)
PBG: 122487396(TCF7)
LRUF: 124515627
PTG: 102957988(TCF7)
PPAD: 109250863(TCF7)
AJU: 106984911(TCF7)
HHV: 120238500(TCF7)
BTA: 782690(TCF7)
BOM: 102266633(TCF7)
BIU: 109562015(TCF7)
BBUB: 102408996(TCF7)
BBIS: 104991933(TCF7)
CHX: 102173736(TCF7)
OAS: 101101980(TCF7)
ODA: 120863661(TCF7)
CCAD: 122439921(TCF7)
SSC: 100512951(TCF7)
CFR: 102519063(TCF7)
CBAI: 105082121(TCF7)
CDK: 105090254(TCF7)
VPC: 102537589(TCF7)
BACU: 103018264(TCF7)
LVE: 103074150(TCF7)
OOR: 101289599(TCF7)
DLE: 111182442(TCF7)
PCAD: 102992878(TCF7)
PSIU: 116752164(TCF7)
ECB: 100072786(TCF7)
EPZ: 103543120(TCF7)
EAI: 106834657(TCF7)
MYB: 102250528(TCF7)
MYD: 102757003(TCF7)
MMYO: 118657631(TCF7)
MLF: 102433022(TCF7)
MNA: 107525397(TCF7)
PKL: 118711889(TCF7)
HAI: 109382635(TCF7)
DRO: 112318180(TCF7)
SHON: 118990084(TCF7)
AJM: 119037608(TCF7)
PDIC: 114509934(TCF7)
PHAS: 123811661(TCF7)
MMF: 118643629(TCF7)
RFQ: 117017071(TCF7)
PALE: 102885788(TCF7)
PGIG: 120581289(TCF7)
PVP: 105293567(TCF7)
RAY: 107506797(TCF7)
MJV: 108406081(TCF7)
TOD: 119243471(TCF7)
SARA: 101540913(TCF7)
LAV: 100663559(TCF7)
TMU: 101350837
ETF: 101657040(TCF7)
DNM: 101411457(TCF7)
MDO: 100017589(TCF7)
GAS: 123237636(TCF7)
SHR: 100930141(TCF7)
PCW: 110211723(TCF7)
OAA: 100082332(TCF7)
GGA: 395229(TCF7)
PCOC: 116232216(TCF7)
MGP: 100544924(TCF7)
CJO: 107320225(TCF7)
NMEL: 110405287(TCF7)
APLA: 101803610(TCF7)
ACYG: 106032766(TCF7)
AFUL: 116495052(TCF7)
TGU: 100221008(TCF7)
LSR: 110481074(TCF7)
SCAN: 103817470(TCF7)
PMOA: 120498623(TCF7)
OTC: 121332492(TCF7)
PRUF: 121361301(TCF7)
GFR: 102036749(TCF7)
FAB: 101820491(TCF7)
PHI: 102110510(TCF7)
PMAJ: 107210639(TCF7)
CCAE: 111935599(TCF7)
CCW: 104683724(TCF7)
CBRC: 103614692(TCF7)
ETL: 114063910(TCF7)
ZAB: 102061135(TCF7)
ACHL: 103807821(TCF7)
FPG: 101919678(TCF7)
FCH: 102058554(TCF7)
CLV: 102094656(TCF7)
EGZ: 104133478(TCF7)
NNI: 104012004(TCF7)
PCAO: 104051181(TCF7)
ACUN: 113485114(TCF7)
TALA: 104365223(TCF7)
PADL: 103915850(TCF7)
AFOR: 103904439(TCF7)
ACHC: 115334089(TCF7)
HLE: 104839072(TCF7)
AGEN: 126051116
GCL: 127021964
CSTI: 104558021(TCF7)
EHS: 104509814(TCF7)
MUI: 104543267
LDI: 104346558
OHA: 104338062(TCF7)
NNT: 104408659
DPUB: 104310141(TCF7)
PGUU: 104459059
ACAR: 104529243
CPEA: 104386840(TCF7)
AVIT: 104274978(TCF7)
CVF: 104292051(TCF7)
CUCA: 104060926(TCF7)
TEO: 104383729
BRHI: 104496022(TCF7)
AAM: 106487174(TCF7)
AROW: 112964702(TCF7)
NPD: 112952974(TCF7)
TGT: 104572832
DNE: 112994146(TCF7)
ASN: 102383175(TCF7)
AMJ: 102576120(TCF7)
CPOO: 109310088(TCF7)
GGN: 109289961(TCF7)
PSS: 102446665(TCF7)
CMY: 102943166(TCF7)
CPIC: 101937399(TCF7)
TST: 117882270(TCF7)
CABI: 116826639(TCF7)
MRV: 120370469(TCF7)
ACS: 100554608(tcf7)
PVT: 110079405(TCF7)
SUND: 121922739(TCF7)
PBI: 103067042(TCF7)
PMUR: 107294908(TCF7)
CTIG: 120305514(TCF7)
TSR: 106542632(TCF7)
PGUT: 117656083(TCF7)
VKO: 123035726(TCF7)
PMUA: 114591268(TCF7)
ZVI: 118080356(TCF7)
GJA: 107125983(TCF7)
STOW: 125429787(TCF7)
XLA: 398658(tcf7.S)
XTR: 395061(tcf7)
NPR: 108792126(TCF7)
BBUF: 121009361(TCF7)
BGAR: 122928266(TCF7)
DRE: 497649(tcf7)
SRX: 107728269 107742437(tcf7)
SANH: 107661683(tcf7) 107692971
CCAR: 109048020
PPRM: 120473621(tcf7)
MAMB: 125253085(tcf7)
IPU: 108278866(tcf7)
PHYP: 113535749
SMEO: 124397852(tcf7)
TFD: 113646522(tcf7)
AMEX: 103045826
EEE: 113578029(tcf7)
TRU: 101076516(tcf7)
LCO: 104924428
NCC: 104960861(tcf7)
CGOB: 115018803(tcf7)
ELY: 117245747 117268549(tcf7)
EFO: 125898881(tcf7)
PLEP: 121952129(tcf7)
SLUC: 116055911(tcf7) 118493643
ECRA: 117955094(tcf7)
ESP: 116679407 116700180(tcf7)
PFLV: 114566424(tcf7)
GAT: 120821561(tcf7)
PPUG: 119215586(tcf7)
MSAM: 119895287(tcf7)
CUD: 121518698(tcf7)
ALAT: 119014087 119031550(tcf7)
MZE: 101469770(tcf7)
ONL: 100710520(tcf7)
OAU: 116315805(tcf7)
OML: 112137216 112142310(tcf7)
XMA: 102221228(tcf7) 111610761
XCO: 114152465(tcf7) 114157642
XHE: 116728111(tcf7) 116732626
PRET: 103460015(tcf7) 103480959
PFOR: 103155760(tcf7)
PLAI: 106935267(tcf7) 106958964
PMEI: 106910477 106916700(tcf7)
GAF: 122820847 122844686(tcf7)
CVG: 107085909(tcf7)
CTUL: 119797145 119797952(tcf7)
GMU: 124876424(tcf7) 124880979
NFU: 107378492 107386837(tcf7)
KMR: 108238102(tcf7)
ALIM: 106524564(tcf7) 106532889
NWH: 119420469(tcf7)
AOCE: 111566135
MCEP: 125020943(tcf7)
CSEM: 103394864(tcf7)
POV: 109635808(tcf7)
SSEN: 122776845 122779518(tcf7)
HSP: 118102942 118121778(tcf7)
LCF: 108893669
SDU: 111234495(tcf7)
SLAL: 111659992(tcf7)
XGL: 120803038(tcf7)
MALB: 109966812(tcf7)
BSPL: 114869348(tcf7)
OMY: 101268913(tcf7) 110537729
SNH: 120044389(tcf7) 120056778
ELS: 105026693
PKI: 111839551
AANG: 118236295(tcf7)
LOC: 102694215(tcf7)
PSEX: 120542075(tcf7)
LCM: 102350321(TCF7)
CMK: 103183678(tcf7)
RTP: 109912241
ACER: 108000102
APLN: 108741021
VDE: 111250602
DFR: 124496842
GAE: 121391070
MYI: 110453946
ATEN: 116297634
 » show all
Reference
PMID:1569101
  Authors
van de Wetering M, Oosterwegel M, Holstege F, Dooyes D, Suijkerbuijk R, Geurts van Kessel A, Clevers H
  Title
The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization.
  Journal
J Biol Chem 267:8530-6 (1992)
  Sequence
[hsa:6932]
Reference
  Authors
Arce L, Yokoyama NN, Waterman ML
  Title
Diversity of LEF/TCF action in development and disease.
  Journal
Oncogene 25:7492-504 (2006)
DOI:10.1038/sj.onc.1210056
Reference
  Authors
Ioannidis V, Beermann F, Clevers H, Held W
  Title
The beta-catenin--TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival.
  Journal
Nat Immunol 2:691-7 (2001)
DOI:10.1038/90623
  Sequence
[mmu:21414]

KEGG   ORTHOLOGY: K04492
Entry
K04492                      KO                                     
Symbol
LEF1
Name
lymphoid enhancer-binding factor 1
Pathway
map04310  Wnt signaling pathway
map04390  Hippo signaling pathway
map04520  Adherens junction
map04916  Melanogenesis
map04934  Cushing syndrome
map04936  Alcoholic liver disease
map05132  Salmonella infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05200  Pathways in cancer
map05210  Colorectal cancer
map05213  Endometrial cancer
map05215  Prostate cancer
map05216  Thyroid cancer
map05217  Basal cell carcinoma
map05221  Acute myeloid leukemia
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05412  Arrhythmogenic right ventricular cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K04492  LEF1; lymphoid enhancer-binding factor 1
   04390 Hippo signaling pathway
    K04492  LEF1; lymphoid enhancer-binding factor 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04492  LEF1; lymphoid enhancer-binding factor 1
 09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    K04492  LEF1; lymphoid enhancer-binding factor 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05225 Hepatocellular carcinoma
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05226 Gastric cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05216 Thyroid cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05221 Acute myeloid leukemia
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05217 Basal cell carcinoma
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05215 Prostate cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05213 Endometrial cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05224 Breast cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04492  LEF1; lymphoid enhancer-binding factor 1
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04492  LEF1; lymphoid enhancer-binding factor 1
  09166 Cardiovascular disease
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04492  LEF1; lymphoid enhancer-binding factor 1
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04492  LEF1; lymphoid enhancer-binding factor 1
   04934 Cushing syndrome
    K04492  LEF1; lymphoid enhancer-binding factor 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04492  LEF1; lymphoid enhancer-binding factor 1
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    K04492  LEF1; lymphoid enhancer-binding factor 1
Genes
HSA: 51176(LEF1)
PTR: 461425(LEF1)
PPS: 100995847(LEF1)
GGO: 101140253(LEF1)
PON: 100447785(LEF1)
NLE: 100593051(LEF1)
MCC: 695776(LEF1)
MCF: 101925349(LEF1)
MTHB: 126954934
CSAB: 103236088(LEF1)
CATY: 105571411(LEF1)
PANU: 101017352(LEF1)
TGE: 112624710(LEF1)
RRO: 104670045(LEF1)
RBB: 108515891(LEF1)
TFN: 117085762(LEF1)
PTEH: 111547880(LEF1)
CANG: 105514397(LEF1)
CJC: 100399759(LEF1)
SBQ: 101047688(LEF1)
CSYR: 103252452(LEF1)
MMUR: 105872329(LEF1)
LCAT: 123627736(LEF1)
PCOQ: 105818969(LEF1)
OGA: 100958411(LEF1)
MMU: 16842(Lef1)
MCAL: 110290892(Lef1)
MPAH: 110319903(Lef1)
RNO: 161452(Lef1)
MCOC: 116093789(Lef1)
MUN: 110553391(Lef1)
CGE: 100761200(Lef1)
MAUA: 101823226(Lef1)
PLEU: 114682816(Lef1)
MORG: 121450203(Lef1)
MFOT: 126509833
AAMP: 119800683(Lef1)
NGI: 103742515(Lef1)
HGL: 101711023(Lef1)
CPOC: 100716066(Lef1)
CCAN: 109688935
DORD: 105991153(Lef1)
DSP: 122127220(Lef1)
NCAR: 124994528
OCU: 100352691
OPI: 101525298(LEF1)
TUP: 102474621(LEF1)
GVR: 103593743(LEF1)
CFA: 478507(LEF1)
CLUD: 112671621(LEF1)
VVP: 112934208(LEF1)
VLG: 121493895(LEF1)
AML: 100465982(LEF1)
UMR: 103661728(LEF1)
UAH: 113255544(LEF1)
UAR: 123793375(LEF1)
ELK: 111154120
LLV: 125093264
MPUF: 101689480(LEF1)
ORO: 101372325(LEF1)
EJU: 114222653(LEF1)
ZCA: 113925268(LEF1)
MLX: 118027079(LEF1)
NSU: 110575521(LEF1)
LWW: 102737827(LEF1)
FCA: 101088077(LEF1)
PYU: 121031433(LEF1)
PBG: 122477660(LEF1)
LRUF: 124520997
PTG: 102970026(LEF1)
PPAD: 109247814(LEF1)
AJU: 106983664(LEF1)
HHV: 120236146(LEF1)
BTA: 535399(LEF1)
BOM: 102266946(LEF1)
BIU: 109560266(LEF1)
BBUB: 102409520(LEF1)
BBIS: 105002090(LEF1)
CHX: 100860901(LEF1)
OAS: 780521(LEF1)
ODA: 120861741(LEF1)
CCAD: 122422034(LEF1)
SSC: 100170126(LEF1)
CFR: 102510619(LEF1)
CBAI: 105067944(LEF1)
CDK: 105105289(LEF1)
VPC: 102541243(LEF1)
BACU: 103020844(LEF1)
LVE: 103068879(LEF1)
OOR: 101287631(LEF1)
DLE: 111171490(LEF1)
PCAD: 102996605(LEF1)
PSIU: 116753891(LEF1)
ECB: 100072938(LEF1)
EPZ: 103557035(LEF1)
EAI: 106829814(LEF1)
MYB: 102255910(LEF1)
MYD: 102767379(LEF1)
MMYO: 118673131(LEF1)
MLF: 102439262(LEF1)
MNA: 107538292(LEF1)
PKL: 118702904(LEF1)
HAI: 109379461(LEF1)
DRO: 112321441(LEF1)
SHON: 118977082(LEF1)
AJM: 119061436(LEF1)
PDIC: 114492280(LEF1)
PHAS: 123806910(LEF1)
MMF: 118637343(LEF1)
RFQ: 117022359(LEF1)
PALE: 102886933(LEF1)
PGIG: 120591231(LEF1)
PVP: 105293004(LEF1)
RAY: 107511497(LEF1)
MJV: 108405595(LEF1)
TOD: 119242944(LEF1)
SARA: 101547696(LEF1)
LAV: 100658960(LEF1)
TMU: 101345125
ETF: 101645834(LEF1)
DNM: 101428006(LEF1)
MDO: 100011783(LEF1)
SHR: 100934638(LEF1)
PCW: 110218610(LEF1)
OAA: 100079818(LEF1)
GGA: 395865(LEF1)
PCOC: 116238078(LEF1)
MGP: 100542839(LEF1)
CJO: 107313267(LEF1)
NMEL: 110398346(LEF1)
APLA: 101792052(LEF1)
ACYG: 106038656(LEF1)
AFUL: 116489255(LEF1)
TGU: 100228376(LEF1)
LSR: 110468005(LEF1)
SCAN: 103826009(LEF1)
PMOA: 120502824(LEF1)
OTC: 121331416(LEF1)
PRUF: 121360221(LEF1)
GFR: 102034937(LEF1)
FAB: 101821185(LEF1)
PHI: 102109576(LEF1)
PMAJ: 107203557(LEF1)
CCAE: 111928334(LEF1)
CCW: 104697293(LEF1)
CBRC: 103617392(LEF1)
ETL: 114057906(LEF1)
ZAB: 102060741(LEF1)
ACHL: 103808312(LEF1)
FPG: 101917929(LEF1)
FCH: 102050307(LEF1)
CLV: 102084626(LEF1)
EGZ: 104135527(LEF1)
NNI: 104021166(LEF1)
PLET: 104622331(LEF1)
PCRI: 104034615(LEF1)
PCAO: 104042542(LEF1)
ACUN: 113479673(LEF1)
TALA: 104357711(LEF1)
PADL: 103919538(LEF1)
AFOR: 103894233(LEF1)
ACHC: 115343254(LEF1)
HALD: 104314291(LEF1)
HLE: 104843344(LEF1)
AGEN: 126044961
GCL: 127015863
CSTI: 104558670(LEF1)
EHS: 104516011(LEF1)
CMAC: 104483274(TCF7)
MUI: 104543451(LEF1)
FGA: 104083813
GSTE: 104254847(LEF1)
LDI: 104353941(LEF1)
MNB: 103777011(LEF1)
OHA: 104327260(LEF1)
NNT: 104411041(LEF1)
DPUB: 104301797(LEF1)
PGUU: 104463233(LEF1)
ACAR: 104518792(LEF1)
CPEA: 104394492(LEF1)
AVIT: 104274896(LEF1)
CVF: 104286847(LEF1)
CUCA: 104062883(LEF1)
TEO: 104377670
AAM: 106491833(LEF1)
AROW: 112972206(LEF1)
NPD: 112957317(LEF1)
TGT: 104578540(LEF1)
DNE: 112987873(LEF1)
SCAM: 104153503(LEF1)
ASN: 102385539(LEF1)
AMJ: 102560337(LEF1)
CPOO: 109309400(LEF1)
GGN: 109301061(LEF1)
PSS: 102456780(LEF1)
CMY: 102930185(LEF1)
CPIC: 101953582(LEF1)
TST: 117878225(LEF1)
CABI: 116837678(LEF1)
MRV: 120406221(LEF1)
ACS: 100556215(lef1)
PVT: 110080460(LEF1)
SUND: 121931875(LEF1)
PBI: 103064656(LEF1)
PMUR: 107302616(LEF1)
CTIG: 120308252(LEF1)
TSR: 106556004(LEF1)
PGUT: 117679923(LEF1)
VKO: 123023106(LEF1)
PMUA: 114603846(LEF1)
ZVI: 118083338(LEF1)
GJA: 107123114(LEF1)
STOW: 125439978(LEF1)
XLA: 398238(lef1.L) 779101(lef1.S)
XTR: 100493178(lef1)
NPR: 108785415(LEF1) 108801973
RTEM: 120917892(LEF1)
BBUF: 120989930(LEF1)
BGAR: 122920359(LEF1)
DRE: 30701(lef1)
SGH: 107583218(lef1) 107594427
CCAR: 109046851
PPRM: 120491182(lef1)
MAMB: 125271927(lef1)
IPU: 108262963(lef1)
PHYP: 113538151(lef1)
SMEO: 124377280(lef1)
TFD: 113642358(lef1)
AMEX: 103033630(lef1)
EEE: 113568617(lef1)
TRU: 101064872(lef1) 115251054
LCO: 104927262(lef1)
NCC: 104953587
CGOB: 115010760(lef1)
ELY: 117255366(lef1)
EFO: 125884388(lef1)
PLEP: 121942444(lef1) 121959099
SLUC: 116034295(lef1)
ECRA: 117957879(lef1)
ESP: 116670487(lef1)
PFLV: 114567774(lef1)
GAT: 120825743(lef1)
PPUG: 119217776(lef1)
MSAM: 119898915(lef1) 119898916
CUD: 121508857(lef1)
ALAT: 119020711(lef1)
MZE: 101464688(lef1)
ONL: 100704365(lef1)
OAU: 116330136(lef1)
OLA: 101167344(lef1)
OML: 112157252(lef1)
XMA: 102226301(lef1) 111609564
XCO: 114144420(lef1) 114149416
XHE: 116719693(lef1)
PRET: 103472749(lef1)
PFOR: 103143923(lef1)
PLAI: 106958163(lef1)
PMEI: 106930845(lef1)
GAF: 122829090(lef1)
CVG: 107094620(lef1)
CTUL: 119779063(lef1)
GMU: 124868243(lef1)
NFU: 107375038(lef1)
KMR: 108230929(lef1)
ALIM: 106517066(lef1)
NWH: 119422647(lef1)
AOCE: 111586156(lef1)
MCEP: 125003806(lef1)
SSEN: 122770862(lef1)
HHIP: 117768294(lef1)
HSP: 118123659(lef1)
LCF: 108888246
SDU: 111236636(lef1)
SLAL: 111671174(lef1)
XGL: 120800237(lef1)
BPEC: 110165341(lef1)
MALB: 109955531(lef1) 109972141
BSPL: 114862393(lef1)
SASA: 106602294 106610340(lef1)
STRU: 115191730(lef1)
OTW: 112239252(lef1)
OGO: 124001502
SNH: 120034764 120035026(lef1)
CCLU: 121580693(lef1)
ELS: 105020989(lef1)
PKI: 111837376(lef1) 111852095
AANG: 118226723(lef1) 118232500
LOC: 102686059(lef1)
PSPA: 121296434 121321759(lef1)
PSEX: 120532281(lef1)
LCM: 102354030(LEF1)
CMK: 103182161
 » show all
Reference
  Authors
Hovanes K, Li TW, Waterman ML
  Title
The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing.
  Journal
Nucleic Acids Res 28:1994-2003 (2000)
DOI:10.1093/nar/28.9.1994
  Sequence
[hsa:51176]
Reference
  Authors
Arce L, Yokoyama NN, Waterman ML
  Title
Diversity of LEF/TCF action in development and disease.
  Journal
Oncogene 25:7492-504 (2006)
DOI:10.1038/sj.onc.1210056

KEGG   ORTHOLOGY: K04491
Entry
K04491                      KO                                     
Symbol
TCF7L2
Name
transcription factor 7-like 2
Pathway
map04310  Wnt signaling pathway
map04390  Hippo signaling pathway
map04520  Adherens junction
map04916  Melanogenesis
map04934  Cushing syndrome
map04936  Alcoholic liver disease
map05132  Salmonella infection
map05165  Human papillomavirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05200  Pathways in cancer
map05210  Colorectal cancer
map05213  Endometrial cancer
map05215  Prostate cancer
map05216  Thyroid cancer
map05217  Basal cell carcinoma
map05221  Acute myeloid leukemia
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05412  Arrhythmogenic right ventricular cardiomyopathy
Disease
H00409  Type 2 diabetes mellitus
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K04491  TCF7L2; transcription factor 7-like 2
   04390 Hippo signaling pathway
    K04491  TCF7L2; transcription factor 7-like 2
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04491  TCF7L2; transcription factor 7-like 2
 09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    K04491  TCF7L2; transcription factor 7-like 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04491  TCF7L2; transcription factor 7-like 2
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05225 Hepatocellular carcinoma
    K04491  TCF7L2; transcription factor 7-like 2
   05226 Gastric cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05216 Thyroid cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05221 Acute myeloid leukemia
    K04491  TCF7L2; transcription factor 7-like 2
   05217 Basal cell carcinoma
    K04491  TCF7L2; transcription factor 7-like 2
   05215 Prostate cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05213 Endometrial cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05224 Breast cancer
    K04491  TCF7L2; transcription factor 7-like 2
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04491  TCF7L2; transcription factor 7-like 2
   05165 Human papillomavirus infection
    K04491  TCF7L2; transcription factor 7-like 2
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04491  TCF7L2; transcription factor 7-like 2
  09166 Cardiovascular disease
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04491  TCF7L2; transcription factor 7-like 2
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04491  TCF7L2; transcription factor 7-like 2
   04934 Cushing syndrome
    K04491  TCF7L2; transcription factor 7-like 2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04491  TCF7L2; transcription factor 7-like 2
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    K04491  TCF7L2; transcription factor 7-like 2
Genes
HSA: 6934(TCF7L2)
PTR: 450743(TCF7L2)
PPS: 100978424(TCF7L2)
GGO: 109025238(TCF7L2)
PON: 100434811(TCF7L2)
NLE: 100605701(TCF7L2)
MCC: 701759(TCF7L2)
MCF: 102116470(TCF7L2)
MTHB: 126962827
CSAB: 103216817(TCF7L2)
CATY: 105577906(TCF7L2)
PANU: 101026705(TCF7L2)
TGE: 112631247(TCF7L2)
RRO: 104664436(TCF7L2)
RBB: 108542456(TCF7L2)
TFN: 117066750(TCF7L2)
PTEH: 111538904(TCF7L2)
CANG: 105501828(TCF7L2)
CJC: 100406757(TCF7L2)
SBQ: 101037011(TCF7L2)
CSYR: 103256089(TCF7L2)
MMUR: 105875160(TCF7L2)
LCAT: 123649863(TCF7L2)
PCOQ: 105826013(TCF7L2)
OGA: 100943434(TCF7L2)
MMU: 21416(Tcf7l2)
MCAL: 110285273(Tcf7l2)
MPAH: 110313411(Tcf7l2)
RNO: 679869(Tcf7l2)
MCOC: 116104020(Tcf7l2)
MUN: 110545126(Tcf7l2)
CGE: 100758400(Tcf7l2)
MAUA: 101831174(Tcf7l2)
PLEU: 114697060(Tcf7l2)
MORG: 121453859(Tcf7l2)
MFOT: 126505923
AAMP: 119806595(Tcf7l2)
NGI: 103731749(Tcf7l2)
HGL: 101710380(Tcf7l2)
CPOC: 100715721(Tcf7l2)
CCAN: 109688561(Tcf7l2)
DORD: 105986725(Tcf7l2)
DSP: 122115716(Tcf7l2)
NCAR: 124984748
OCU: 100358378
OPI: 101521047(TCF7L2)
TUP: 102472810(TCF7L2)
GVR: 103589124(TCF7L2)
CFA: 486894(TCF7L2)
CLUD: 112672346(TCF7L2)
VVP: 112916157(TCF7L2)
VLG: 121485032(TCF7L2)
AML: 100467719(TCF7L2)
UMR: 103657263(TCF7L2)
UAH: 113251942(TCF7L2)
UAR: 123795969(TCF7L2)
ELK: 111145217
LLV: 125084325
MPUF: 101676452(TCF7L2)
ORO: 101385846(TCF7L2)
ZCA: 113923025(TCF7L2)
MLX: 118026323(TCF7L2)
NSU: 110589494(TCF7L2)
LWW: 102745990(TCF7L2)
FCA: 101095618(TCF7L2)
PYU: 121037238(TCF7L2)
PBG: 122493255(TCF7L2)
LRUF: 124507146
PTG: 102961321(TCF7L2)
PPAD: 109272915(TCF7L2)
AJU: 106974119(TCF7L2)
HHV: 120235337(TCF7L2)
BTA: 540481(TCF7L2)
BOM: 102272230(TCF7L2)
BIU: 109553057(TCF7L2)
BBUB: 102393101(TCF7L2)
BBIS: 105002610(TCF7L2)
CHX: 102180102(TCF7L2)
OAS: 101118068(TCF7L2)
ODA: 120873902(TCF7L2)
CCAD: 122445909(TCF7L2)
SSC: 100153922(TCF7L2)
CFR: 102510763(TCF7L2)
CBAI: 105080737(TCF7L2)
CDK: 105091689(TCF7L2)
VPC: 102525508(TCF7L2)
BACU: 103010923(TCF7L2)
LVE: 103068781(TCF7L2)
OOR: 101288107(TCF7L2)
DLE: 111172300(TCF7L2)
PCAD: 102987858(TCF7L2)
PSIU: 116741601(TCF7L2)
ECB: 100059146(TCF7L2)
EPZ: 103564289(TCF7L2)
EAI: 106848101(TCF7L2)
MYB: 102245737(TCF7L2)
MYD: 102767014(TCF7L2)
MMYO: 118669739(TCF7L2)
MLF: 102428683(TCF7L2)
MNA: 107536455(TCF7L2)
PKL: 118719486(TCF7L2)
HAI: 109384898(TCF7L2)
DRO: 112300313(TCF7L2)
SHON: 118999410(TCF7L2)
AJM: 119040094(TCF7L2)
PDIC: 114496676(TCF7L2)
PHAS: 123828741(TCF7L2)
MMF: 118632022(TCF7L2)
RFQ: 117035906(TCF7L2)
PALE: 102880370(TCF7L2)
PGIG: 120609085(TCF7L2)
PVP: 105291480(TCF7L2)
RAY: 107511705(TCF7L2)
MJV: 108408173(TCF7L2)
TOD: 119234547(TCF7L2)
SARA: 101546297(TCF7L2)
LAV: 100656106(TCF7L2)
TMU: 101345532
ETF: 101657493(TCF7L2)
DNM: 101433286(TCF7L2)
MDO: 100021451(TCF7L2)
GAS: 123238173(TCF7L2)
SHR: 100922675(TCF7L2)
PCW: 110209517(TCF7L2)
OAA: 100080633(TCF7L2)
GGA: 395508(TCF7L2)
PCOC: 116231615(TCF7L2)
MGP: 100545943
CJO: 107316122(TCF7L2)
NMEL: 110399432(TCF7L2)
APLA: 101790790(TCF7L2)
ACYG: 106031894(TCF7L2)
AFUL: 116491447(TCF7L2)
TGU: 100229459(TCF7L2)
LSR: 110468252(TCF7L2)
SCAN: 103814128(TCF7L2)
PMOA: 120501961(TCF7L2)
OTC: 121341849(TCF7L2)
PRUF: 121350212(TCF7L2)
GFR: 102035103(TCF7L2)
FAB: 101808150(TCF7L2)
PHI: 102110960(TCF7L2)
PMAJ: 107206579(TCF7L2)
CCAE: 111930957(TCF7L2)
CCW: 104695213(TCF7L2)
CBRC: 103616275(TCF7L2)
ETL: 114057387(TCF7L2)
ZAB: 102075283(TCF7L2)
ACHL: 103800973(TCF7L2)
FPG: 101911463(TCF7L2)
FCH: 102053252(TCF7L2)
CLV: 102092542(TCF7L2)
EGZ: 104130428(TCF7L2)
NNI: 104022375(TCF7L2)
PLET: 104620802(TCF7L2)
PCRI: 104033644(TCF7L2)
PCAO: 104051703(TCF7L2)
ACUN: 113481635(TCF7L2)
TALA: 104368758(TCF7L2)
PADL: 103918670(TCF7L2)
AFOR: 103897740(TCF7L2)
ACHC: 115348196(TCF7L2)
HALD: 104324218(TCF7L2)
HLE: 104830209(TCF7L2)
AGEN: 126043148
GCL: 127017519
CCRI: 104158774
CSTI: 104553138(TCF7L2)
EHS: 104510766
CMAC: 104478637(TCF7L2)
MUI: 104548075(TCF7L2)
FGA: 104083847(TCF7L2)
GSTE: 104263863
LDI: 104346347(TCF7L2)
MNB: 103774896
OHA: 104329504(TCF7L2)
NNT: 104411918(TCF7L2)
DPUB: 104307193(TCF7L2)
PGUU: 104464988
ACAR: 104527872(TCF7L2)
CPEA: 104397916(TCF7L2)
CVF: 104283459(TCF7L2)
CUCA: 104067818(TCF7L2)
TEO: 104384501(TCF7L2)
AAM: 106483723(TCF7L2)
AROW: 112967920(TCF7L2)
NPD: 112957063(TCF7L2)
TGT: 104570256
DNE: 112993664(TCF7L2)
SCAM: 104140131
ASN: 102373887(TCF7L2)
AMJ: 102558653(TCF7L2)
CPOO: 109324083(TCF7L2)
GGN: 109287622(TCF7L2)
PSS: 102459521(TCF7L2)
CMY: 102935138(TCF7L2)
CPIC: 101938831(TCF7L2)
TST: 117879792(TCF7L2)
CABI: 116832677(TCF7L2)
MRV: 120409598(TCF7L2)
ACS: 100561311(tcf7l2) 100563899
PVT: 110071969(TCF7L2)
SUND: 121924798(TCF7L2)
PBI: 103067231(TCF7L2)
PMUR: 107286251(TCF7L2)
CTIG: 120312245(TCF7L2)
TSR: 106550184(TCF7L2)
PGUT: 117678715(TCF7L2)
VKO: 123027730(TCF7L2)
PMUA: 114597477(TCF7L2)
ZVI: 118093455(TCF7L2)
GJA: 107121002(TCF7L2)
STOW: 125437427(TCF7L2)
XLA: 108697306 399164(tcf7l2.L)
XTR: 100101719(tcf7l2)
NPR: 108793512(TCF7L2)
RTEM: 120946834(TCF7L2)
BBUF: 121005422(TCF7L2)
BGAR: 122939052(TCF7L2)
DRE: 30510(tcf7l2)
PPRM: 120474612(tcf7l2)
MAMB: 125255599(tcf7l2)
IPU: 108274114(tcf7l2)
PHYP: 113527302(tcf7l2)
SMEO: 124388632(tcf7l2)
TFD: 113638911(tcf7l2)
AMEX: 103031257(tcf7l2)
EEE: 113577640
TRU: 101067664(tcf7l2) 115250775
LCO: 104932553(tcf7l2)
NCC: 104943463(tcf7l2)
CGOB: 115024930(tcf7l2)
ELY: 117247028(tcf7l2)
EFO: 125880423(tcf7l2)
PLEP: 121958519(tcf7l2)
SLUC: 116061043(tcf7l2)
ECRA: 117936627(tcf7l2)
ESP: 116671026(tcf7l2)
PFLV: 114547666(tcf7l2)
GAT: 120819326(tcf7l2)
PPUG: 119213174(tcf7l2)
MSAM: 119911965 119915700(tcf7l2)
CUD: 121528169(tcf7l2)
ALAT: 119009368(tcf7l2)
MZE: 101472434 101473558(tcf7l2)
OLA: 101169492(tcf7l2)
OML: 112154020(tcf7l2)
XMA: 102216716(tcf7l2)
XCO: 114151877(tcf7l2)
XHE: 116726851(tcf7l2)
PRET: 103473336 103481429(tcf7l2)
PFOR: 103142270(tcf7l2)
PLAI: 106949585
PMEI: 106920911(tcf7l2)
GAF: 122822874(tcf7l2)
CVG: 107090000(tcf7l2)
CTUL: 119774953(tcf7l2)
GMU: 124874826(tcf7l2)
NFU: 107387573(tcf7l2) 107396480
KMR: 108248252(tcf7l2)
ALIM: 106534544(tcf7l2)
NWH: 119424011(tcf7l2)
AOCE: 111579048(tcf7l2)
MCEP: 125022588(tcf7l2)
CSEM: 103381486(tcf7l2) 103385014
POV: 109627028(tcf7l2)
SSEN: 122759724(tcf7l2)
HHIP: 117753439(tcf7l2)
HSP: 118100785(tcf7l2)
LCF: 108901696
SDU: 111219725(tcf7l2)
SLAL: 111657117(tcf7l2)
XGL: 120794076(tcf7l2)
HCQ: 109513392(tcf7l2)
BPEC: 110154410(tcf7l2)
MALB: 109962891(tcf7l2)
BSPL: 114846309(tcf7l2)
OGO: 124039973 124048226(tcf7l2)
ELS: 105007703(tcf7l2)
SFM: 108932732 108940446(tcf7l2)
PKI: 111858155(tcf7l2)
AANG: 118220560(tcf7l2)
LOC: 102691677(tcf7l2)
PSEX: 120543224(tcf7l2)
LCM: 102346208(TCF7L2)
CMK: 103186546(tcf7l2)
RTP: 109926936(tcf7l2)
BFO: 118412533
BBEL: 109485396
CIN: 778773(tcf/lef)
SPU: 373203(Tcf/Lef)
APLC: 110984316
SKO: 100303556(tcf7l)
DME: Dmel_CG34403(pan)
DER: 6555877
DSI: Dsimw501_GD17850(Dsim_pan)
DSR: 110185475
DPO: 4811795
DPE: 6602541
DMN: 108164406
DWI: 6650061
DGR: 6570275
DAZ: 108617901
DHE: 111597895
BOD: 106619378
SCAC: 106082602
LCQ: 111687000
ASTE: 118503338
CNS: 116340013
BCOO: 119079471
AME: 726671
ALAB: 122717456
BIM: 100745788
BTER: 100643645
BPYO: 122566945
CCAL: 108623756
OBB: 114877554
MGEN: 117223795
NMEA: 116427844
CGIG: 122404573
SOC: 105198489
MPHA: 105837174
AEC: 105151104
ACEP: 105619854
PBAR: 105424403
VEM: 105566494
HST: 105186992
DQU: 106742176
CFO: 105253941
LHU: 105675787
PGC: 109859232
OBO: 105281955
PCF: 106793924
VPS: 122627622
NVI: 100120687
CSOL: 105360929
TPRE: 106659629
MDL: 103575344
CGLO: 123270387
FAS: 105268008
DAM: 107039091
AGIF: 122855368
LHT: 122508891
CCIN: 107269034
TCA: 641465(Pan)
DPA: 109535398
SOY: 115883697
ATD: 109595558
CSET: 123323004
AGB: 108911640
LDC: 111509897
NVL: 108564096
PPYR: 116175025
OTU: 111424736
BMOR: 101742450
BMAN: 114239539
MSEX: 115453597
BANY: 112058326
NIQ: 126777880
PMAC: 106719867
PPOT: 106111393
PXU: 106123142
PRAP: 110998995
PBX: 123714889
PNAP: 125057040
ZCE: 119837715
CCRC: 123703406
HAW: 110372629
HZE: 124642598
TNL: 113497924
SLIU: 111362072
OFU: 114365195
PXY: 105381194
API: 100161896
AGS: 114118917
RMD: 113550243
BTAB: 109030753
DCI: 103521547
CLEC: 106664004
HHAL: 106686555
NLU: 111047051
FOC: 113213663
TPAL: 117646745
ZNE: 110830984
CSEC: 111867222
FCD: 110843907
DMK: 116929407
PVM: 113807509
PJA: 122263035
PCHN: 125026380
HAME: 121861552
PCLA: 123753598
PTRU: 123515241
HAZT: 108681978
EAF: 111718027
DSV: 119437031
RSAN: 119393871
RMP: 119161120
VJA: 111267083
DPTE: 113799178
CEL: CELE_W10C8.2(pop-1)
TSP: Tsp_02818
PCAN: 112561450
BGT: 106050505
GAE: 121379435
HRF: 124151751
HRJ: 124284145
CRG: 105329818
MYI: 110453906
PMAX: 117329520
MMER: 123563751
OBI: 106876393
OSN: 115213272
LAK: 106155607
NVE: 5503766
ADF: 107340855
AMIL: 114964939
PDAM: 113677974
SPIS: 111346760
DGT: 114528487
XEN: 124459201
HMG: 100199257
AQU: 100641322(Tcf)
 » show all
Reference
  Authors
Prokunina-Olsson L, Welch C, Hansson O, Adhikari N, Scott LJ, Usher N, Tong M, Sprau A, Swift A, Bonnycastle LL, Erdos MR, He Z, Saxena R, Harmon B, Kotova O, Hoffman EP, Altshuler D, Groop L, Boehnke M, Collins FS, Hall JL
  Title
Tissue-specific alternative splicing of TCF7L2.
  Journal
Hum Mol Genet 18:3795-804 (2009)
DOI:10.1093/hmg/ddp321
  Sequence
[hsa:6934]
Reference
PMID:9065401
  Authors
Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, Kinzler KW, Vogelstein B, Clevers H
  Title
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma.
  Journal
Science 275:1784-7 (1997)
DOI:10.1126/science.275.5307.1784
  Sequence
[hsa:6934]

KEGG   ORTHOLOGY: K04490
Entry
K04490                      KO                                     
Symbol
TCF7L1
Name
transcription factor 7-like 1
Pathway
map04310  Wnt signaling pathway
map04390  Hippo signaling pathway
map04520  Adherens junction
map04916  Melanogenesis
map04934  Cushing syndrome
map04936  Alcoholic liver disease
map05132  Salmonella infection
map05165  Human papillomavirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05200  Pathways in cancer
map05210  Colorectal cancer
map05213  Endometrial cancer
map05215  Prostate cancer
map05216  Thyroid cancer
map05217  Basal cell carcinoma
map05221  Acute myeloid leukemia
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05412  Arrhythmogenic right ventricular cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K04490  TCF7L1; transcription factor 7-like 1
   04390 Hippo signaling pathway
    K04490  TCF7L1; transcription factor 7-like 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04490  TCF7L1; transcription factor 7-like 1
 09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    K04490  TCF7L1; transcription factor 7-like 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04490  TCF7L1; transcription factor 7-like 1
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05225 Hepatocellular carcinoma
    K04490  TCF7L1; transcription factor 7-like 1
   05226 Gastric cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05216 Thyroid cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05221 Acute myeloid leukemia
    K04490  TCF7L1; transcription factor 7-like 1
   05217 Basal cell carcinoma
    K04490  TCF7L1; transcription factor 7-like 1
   05215 Prostate cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05213 Endometrial cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05224 Breast cancer
    K04490  TCF7L1; transcription factor 7-like 1
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04490  TCF7L1; transcription factor 7-like 1
   05165 Human papillomavirus infection
    K04490  TCF7L1; transcription factor 7-like 1
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04490  TCF7L1; transcription factor 7-like 1
  09166 Cardiovascular disease
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04490  TCF7L1; transcription factor 7-like 1
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04490  TCF7L1; transcription factor 7-like 1
   04934 Cushing syndrome
    K04490  TCF7L1; transcription factor 7-like 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04490  TCF7L1; transcription factor 7-like 1
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    K04490  TCF7L1; transcription factor 7-like 1
Genes
HSA: 83439(TCF7L1)
PTR: 744526(TCF7L1)
PPS: 100968002(TCF7L1)
GGO: 101151621(TCF7L1)
PON: 100436197(TCF7L1)
NLE: 100601518(TCF7L1)
MCC: 694560(TCF7L1)
MCF: 102125513(TCF7L1)
MTHB: 126933391
CSAB: 103219950(TCF7L1)
CATY: 105587638(TCF7L1)
PANU: 101017547(TCF7L1)
TGE: 112604528(TCF7L1)
RRO: 104659731(TCF7L1)
RBB: 108542809(TCF7L1)
TFN: 117062119(TCF7L1)
PTEH: 111551134(TCF7L1)
CANG: 105527514(TCF7L1)
CJC: 100385633
SBQ: 101033762(TCF7L1)
CSYR: 103266761
MMUR: 105876584(TCF7L1)
LCAT: 123637116(TCF7L1)
PCOQ: 105810284(TCF7L1)
OGA: 100940553(TCF7L1)
MMU: 21415(Tcf7l1)
MCAL: 110296038(Tcf7l1)
MPAH: 110315696(Tcf7l1)
RNO: 312451(Tcf7l1)
MCOC: 116099088(Tcf7l1)
CGE: 100753225(Tcf7l1)
MAUA: 101839395(Tcf7l1) 121142589
PLEU: 114681591(Tcf7l1)
MORG: 121437942(Tcf7l1)
MFOT: 126493279
AAMP: 119807723(Tcf7l1)
NGI: 103739783(Tcf7l1)
HGL: 101699909(Tcf7l1)
CPOC: 100731379(Tcf7l1)
CCAN: 109686184(Tcf7l1)
DORD: 106000204(Tcf7l1)
DSP: 122116902(Tcf7l1)
NCAR: 124963199
OCU: 100340471
OPI: 101522406(TCF7L1)
TUP: 102481394(TCF7L1)
GVR: 103585949(TCF7L1)
CFA: 612070(TCF7L1)
CLUD: 112664304(TCF7L1)
VVP: 112916685(TCF7L1)
VLG: 121490511(TCF7L1)
AML: 100480690(TCF7L1)
UMR: 103671448(TCF7L1)
UAH: 113243231(TCF7L1)
UAR: 123799645(TCF7L1)
ELK: 111148131
LLV: 125108462
MPUF: 101670990(TCF7L1)
ORO: 101382778(TCF7L1)
EJU: 114223462(TCF7L1)
ZCA: 113938298(TCF7L1)
MLX: 118007920(TCF7L1)
NSU: 110587588(TCF7L1)
LWW: 102731685(TCF7L1)
FCA: 101089850(TCF7L1)
PYU: 121019121(TCF7L1)
PBG: 122497097(TCF7L1)
LRUF: 124503502
PTG: 102958078(TCF7L1)
PPAD: 109263707(TCF7L1)
AJU: 106978197(TCF7L1)
HHV: 120220478(TCF7L1)
BTA: 515303(TCF7L1)
BOM: 102281039(TCF7L1)
BIU: 109565564(TCF7L1)
BBUB: 102410081(TCF7L1)
BBIS: 105004594(TCF7L1)
CHX: 102187776(TCF7L1)
OAS: 100913162(TCF7L1)
ODA: 120851515(TCF7L1)
CCAD: 122441729(TCF7L1)
SSC: 100523899(TCF7L1)
CFR: 102516787(TCF7L1)
CBAI: 105072093(TCF7L1)
CDK: 105104146(TCF7L1)
VPC: 102525926(TCF7L1)
BACU: 103010166(TCF7L1)
LVE: 103069353(TCF7L1)
OOR: 101287223(TCF7L1)
DLE: 111165393(TCF7L1)
PCAD: 102974053(TCF7L1)
PSIU: 116764402(TCF7L1)
ECB: 100067427(TCF7L1)
EPZ: 103548276(TCF7L1)
EAI: 106838609(TCF7L1)
MYB: 102240393(TCF7L1)
MYD: 102768915(TCF7L1)
MMYO: 118668800(TCF7L1)
MLF: 102417756(TCF7L1)
MNA: 107528616(TCF7L1)
PKL: 118717604(TCF7L1)
HAI: 109371340(TCF7L1)
DRO: 112302951(TCF7L1)
SHON: 118982463(TCF7L1) 118989528
AJM: 119059869(TCF7L1)
PDIC: 114499663(TCF7L1)
PHAS: 123811980(TCF7L1)
MMF: 118630569(TCF7L1)
RFQ: 117033407(TCF7L1)
PALE: 102886093(TCF7L1)
PGIG: 120594603(TCF7L1)
PVP: 105298541(TCF7L1)
RAY: 107506285(TCF7L1)
MJV: 108405898(TCF7L1)
TOD: 119259123(TCF7L1)
SARA: 101550691(TCF7L1)
TMU: 101341696
ETF: 101655177(TCF7L1)
DNM: 101417902(TCF7L1)
MDO: 100030368(TCF7L1)
GAS: 123233138(TCF7L1)
SHR: 100922609(TCF7L1)
PCW: 110196343(TCF7L1)
OAA: 114817948(TCF7L1)
GGA: 395230(TCF7L1)
PCOC: 116231327(TCF7L1)
MGP: 104917108(TCF7L1)
CJO: 107323707(TCF7L1)
NMEL: 110387133(TCF7L1)
APLA: 101801135(TCF7L1)
ACYG: 106048886(TCF7L1)
AFUL: 116499387(TCF7L1)
TGU: 115498209(TCF7L1)
LSR: 110478270(TCF7L1)
PMOA: 120505008(TCF7L1)
OTC: 121346667(TCF7L1)
PRUF: 121359809(TCF7L1)
GFR: 102039905(TCF7L1)
FAB: 101817952(TCF7L1)
PHI: 102105833(TCF7L1)
PMAJ: 107213891(TCF7L1)
CCAE: 111938914(TCF7L1)
CCW: 104683181(TCF7L1)
CBRC: 103620244(TCF7L1)
ETL: 114070472(TCF7L1)
FPG: 101922879(TCF7L1)
FCH: 102051021(TCF7L1)
CLV: 102084814(TCF7L1)
NNI: 104022615(TCF7L1)
TALA: 104362330(TCF7L1)
AFOR: 103904221(TCF7L1)
ACHC: 115349900(TCF7L1)
HLE: 104828923(TCF7L1)
AGEN: 126051625
GCL: 127025235
CCRI: 104165649
CPEA: 104392687(TCF7L1)
CVF: 104285063(TCF7L1)
CUCA: 104067006(TCF7L1)
AAM: 106497459
AROW: 112971101(TCF7L1)
DNE: 112994866
ASN: 102382172(TCF7L1)
AMJ: 102559656(TCF7L1)
CPOO: 109324635(TCF7L1)
GGN: 109286704(TCF7L1)
PSS: 102456229(TCF7L1)
CMY: 102947844(TCF7L1)
CPIC: 101943923(TCF7L1)
TST: 117872874(TCF7L1)
CABI: 116820735(TCF7L1)
MRV: 120397584(TCF7L1)
ACS: 100553130(tcf7l1)
PVT: 110084320(TCF7L1)
SUND: 121934613(TCF7L1)
PBI: 103066724(TCF7L1)
PMUR: 107286235(TCF7L1)
CTIG: 120313945(TCF7L1)
TSR: 106539368(TCF7L1)
PGUT: 117677059(TCF7L1)
VKO: 123027052(TCF7L1)
PMUA: 114585748(TCF7L1)
ZVI: 118097303(TCF7L1)
GJA: 107117396(TCF7L1)
STOW: 125441754(TCF7L1)
XLA: 394281(tcf7l1.S) 397863(tcf7l1.L)
XTR: 448107(tcf7l1)
NPR: 108792469
RTEM: 120933071(TCF7L1)
BBUF: 120986167(TCF7L1)
BGAR: 122929474(TCF7L1)
DRE: 30523(tcf7l1a) 30556(tcf7l1b)
PPRM: 120474207(tcf7l1a) 120481307(tcf7l1b)
MAMB: 125262345(tcf7l1a) 125280430(tcf7l1b)
IPU: 108265410(tcf7l1b)
PHYP: 113546045
SMEO: 124399623(tcf7l1b)
TFD: 113645099(tcf7l1b)
AMEX: 103022374
NCC: 104946533(tcf7l1)
EFO: 125890368(tcf7l1b) 125905690
PLEP: 121938910 121944425(tcf7l1b)
SLUC: 116041786 116053887(tcf7l1b)
PPUG: 119224565(tcf7l1b) 119226883
ALAT: 119019317(tcf7l1b) 119030554(tcf7l1a)
MZE: 101466461 101481605(tcf7l1)
OLA: 100820729(tcf7l1) 111948314
OML: 112148818(tcf7l1b) 112162929
GAF: 122828060(tcf7l1b) 122847224
CTUL: 119783953(tcf7l1b)
GMU: 124872815 124878390(tcf7l1b)
NFU: 107393717(tcf7l1) 107395259
KMR: 108236527(tcf7l1b) 108242566
ALIM: 106513792 106520143(tcf7l1)
MCEP: 124996986 125012430(tcf7l1b)
SSEN: 122758446 122769535(tcf7l1b)
HHIP: 117767600(tcf7l1b) 117771319(tcf7l1a)
HSP: 118114860(tcf7l1b) 118126041(tcf7l1a)
XGL: 120805718(tcf7l1b) 120806258
MALB: 109954978
BSPL: 114861532(tcf7l1b) 114866425
SFM: 108923598 108929514(tcf7l1)
PKI: 111837756 111857498(tcf7l1)
AANG: 118206870(tcf7l1b)
LOC: 102692120(tcf7l1)
PSEX: 120538925(tcf7l1a)
LCM: 102364488(TCF7L1)
 » show all
Reference
  Authors
Arce L, Yokoyama NN, Waterman ML
  Title
Diversity of LEF/TCF action in development and disease.
  Journal
Oncogene 25:7492-504 (2006)
DOI:10.1038/sj.onc.1210056
Reference
PMID:1741298
  Authors
Castrop J, van Norren K, Clevers H
  Title
A gene family of HMG-box transcription factors with homology to TCF-1.
  Journal
Nucleic Acids Res 20:611 (1992)
DOI:10.1093/nar/20.3.611
  Sequence
[hsa:83439]

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