KEGG   ORTHOLOGY: K02740
Entry
K02740                      KO                                     

Name
PSMB8, LMP7
Definition
20S proteasome subunit beta 8 [EC:3.4.25.1]
Pathway
ko03050  Proteasome
Disease
H01741  Autoinflammation lipodystrophy and dermatosis syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    K02740  PSMB8, LMP7; 20S proteasome subunit beta 8
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K02740  PSMB8, LMP7; 20S proteasome subunit beta 8
  09182 Protein families: genetic information processing
   03051 Proteasome
    K02740  PSMB8, LMP7; 20S proteasome subunit beta 8
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.25  Threonine endopeptidases
    3.4.25.1  proteasome endopeptidase complex
     K02740  PSMB8, LMP7; 20S proteasome subunit beta 8
Peptidases and inhibitors [BR:ko01002]
 Threonine peptidases
  Family T1: proteasome family
   K02740  PSMB8, LMP7; 20S proteasome subunit beta 8
Proteasome [BR:ko03051]
 Eukaryotic proteasome
  Core particles (20S proteasome)
   beta type subunits
    K02740  PSMB8, LMP7; 20S proteasome subunit beta 8
Genes
HSA: 5696(PSMB8)
PTR: 746418(PSMB8)
PPS: 100969919(PSMB8)
GGO: 101136133(PSMB8)
PON: 100445244(PSMB8)
NLE: 100604916(PSMB8)
MCC: 717766(PSMB8)
MCF: 102141301(PSMB8)
CSAB: 103221690(PSMB8)
RRO: 104666627(PSMB8)
RBB: 108512978(PSMB8)
CJC: 100406682(PSMB8)
SBQ: 101050853
MMU: 16913(Psmb8)
MCAL: 110312690(Psmb8)
MPAH: 110335701(Psmb8)
RNO: 24968(Psmb8)
MUN: 110543263(Psmb8)
CGE: 100751746(Psmb8)
NGI: 103748237(Psmb8)
HGL: 101702300(Psmb8)
CCAN: 109686708(Psmb8)
OCU: 100351918(PSMB8)
TUP: 102484029(PSMB8)
CFA: 474865(PSMB8)
VVP: 112913863(PSMB8)
AML: 100477784(PSMB8)
UMR: 103665514(PSMB8)
UAH: 113243782(PSMB8)
ORO: 101371019(PSMB8)
ELK: 111152369
PTG: 102958580(PSMB8)
PPAD: 109271412(PSMB8)
AJU: 106976129(PSMB8)
BTA: 282013(PSMB8)
BOM: 102283566(PSMB8)
BIU: 109577141(PSMB8)
BBUB: 102391390(PSMB8)
CHX: 102180902(PSMB8)
OAS: 100174905(PSMB8)
SSC: 396975(PSMB8)
CFR: 102519631(PSMB8)
CDK: 105101405(PSMB8)
BACU: 103011762(PSMB8)
LVE: 103084339(PSMB8)
OOR: 101290117(PSMB8)
DLE: 111178661(PSMB8)
PCAD: 102995453(PSMB8)
ECB: 100052481(PSMB8)
EPZ: 103544695(PSMB8)
EAI: 106834614(PSMB8)
MYB: 102245229(PSMB8)
MYD: 102761800(PSMB8)
MNA: 107542675(PSMB8)
HAI: 109378147(PSMB8)
DRO: 112302285(PSMB8)
PALE: 102893806(PSMB8)
RAY: 107511997(PSMB8)
MJV: 108408873
LAV: 100664123(PSMB8)
TMU: 101342060
MDO: 100026706(PSMB8)
SHR: 116423204(PSMB8)
PCW: 110199437(PSMB8)
OAA: 100529058(PSMB8)
ASN: 106722823
AMJ: 109286085(PSMB8)
CPIC: 101952518(PSMB8)
ACS: 100559169(psmb8)
PVT: 110071035
PBI: 103057075(PSMB8)
PMUR: 107298997
XLA: 379720(MGC69086) 399439(psmb8.L)
XTR: 100485711 445258(psmb8)
NPR: 108788367(PSMB8)
DRE: 30666(psmb8a) 550488(psmb8f)
AMEX: 103025308
EEE: 113581270
TRU: 101077532(psmb8) 115251835
LCO: 104933383(psmb8)
NCC: 104959103
MZE: 101480087(psmb8)
ONL: 100697999(psmb8)
OLA: 100049532(psmb8)
XMA: 102219510
XCO: 114156482
CVG: 107104176 107104819(psmb8)
NFU: 107394859(psmb8)
KMR: 108242638
ALIM: 106519544(psmb8)
AOCE: 111584577(psmb8)
CSEM: 103393841(psmb8)
POV: 109646446
SDU: 111239427(psmb8)
SLAL: 111661206(psmb8)
BPEC: 110173314(psmb8)
SASA: 100136367(psmb8b) 106588400(LMP7)
ELS: 105009104
SFM: 108930382(psmb8)
PKI: 111835645
LCM: 102358775(PSMB8)
CMK: 103171674
 » show all
Reference
  Authors
Strehl B, Seifert U, Kruger E, Heink S, Kuckelkorn U, Kloetzel PM
  Title
Interferon-gamma, the functional plasticity of the ubiquitin-proteasome system, and MHC class I antigen processing.
  Journal
Immunol Rev 207:19-30 (2005)
DOI:10.1111/j.0105-2896.2005.00308.x
Reference
  Authors
Kitamura A, Maekawa Y, Uehara H, Izumi K, Kawachi I, Nishizawa M, Toyoshima Y, Takahashi H, Standley DM, Tanaka K, Hamazaki J, Murata S, Obara K, Toyoshima I, Yasutomo K
  Title
A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans.
  Journal
J Clin Invest 121:4150-60 (2011)
DOI:10.1172/JCI58414
  Sequence
[hsa:5696]

DBGET integrated database retrieval system