KEGG ORTHOLOGY: K02861

ORTHOLOGY: K02861

Entry

K02861                      KO

Symbol

RIPK1, RIP1

Name

receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]

Pathway

map04064

NF-kappa B signaling pathway

map04210

Apoptosis

map04217

Necroptosis

map04620

Toll-like receptor signaling pathway

map04621

NOD-like receptor signaling pathway

map04622

RIG-I-like receptor signaling pathway

map04623

Cytosolic DNA-sensing pathway

map04668

TNF signaling pathway

map04936

Alcoholic liver disease

map05130

Pathogenic Escherichia coli infection

map05131

Shigellosis

map05132

Salmonella infection

map05160

Hepatitis C

map05163

Human cytomegalovirus infection

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

Disease

H02525

Disorders of innate immunity

H02620

Autoinflammation with episodic fever and lymphadenopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   04668 TNF signaling pathway
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   04217 Necroptosis
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   04621 NOD-like receptor signaling pathway
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   04622 RIG-I-like receptor signaling pathway
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   04623 Cytosolic DNA-sensing pathway
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   05160 Hepatitis C
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   05163 Human cytomegalovirus infection
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   05169 Epstein-Barr virus infection
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   05132 Salmonella infection
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   05131 Shigellosis
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
Protein kinases [BR:ko01001]
Serine/threonine kinases: TKL group
  RIPK family [OT]
   K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1

Genes

HSA:	8737(RIPK1)

PTR:	462397(RIPK1)

PPS:	100991521(RIPK1)

GGO:	101153833(RIPK1)

PON:	100449028(RIPK1)

PPYG:

129039560(RIPK1)

NLE:	100599272(RIPK1)

HMH:	116459720(RIPK1)

SSYN:

129473776(RIPK1)

MCC:	708013(RIPK1)

MCF:	101926590(RIPK1)

MTHB:

126952524

MNI:	105487318(RIPK1)

CSAB:

103222283(RIPK1)

CATY:

105596428(RIPK1)

PANU:

101011511(RIPK1)

TGE:	112622229(RIPK1)

MLEU:

105542896(RIPK1)

RRO:	104661228(RIPK1)

RBB:	108514229(RIPK1)

TFN:	117086621(RIPK1)

PTEH:

111548565(RIPK1)

CANG:

105507091(RIPK1)

CJC:	100415562(RIPK1)

SBQ:	101047042(RIPK1)

CIMI:

108281783(RIPK1)

ANAN:

105708733(RIPK1)

CSYR:

103272007(RIPK1)

MMUR:

105873484(RIPK1)

LCAT:

123638176(RIPK1)

PCOQ:

105816051(RIPK1)

OGA:	100949124(RIPK1)

MMU:	19766(Ripk1)

MCAL:

110307946(Ripk1)

MPAH:

110333762(Ripk1)

RNO:	306886(Ripk1)

MCOC:

116082569(Ripk1)

ANU:	117713706(Ripk1)

MUN:	110561376(Ripk1)

CGE:	100761116(Ripk1)

MAUA:

101835042(Ripk1)

PROB:

127229356(Ripk1)

PLEU:

114701254(Ripk1)

MORG:

121433918(Ripk1)

MFOT:

126501520

AAMP:

119816683(Ripk1)

NGI:	103732937(Ripk1)

HGL:	101696605(Ripk1)

CPOC:

100727211(Ripk1)

CCAN:

109695449(Ripk1)

DORD:

105985992(Ripk1)

DSP:	122108407(Ripk1)

PLOP:

125353067(Ripk1)

NCAR:

124989445

MMMA:

107149201(Ripk1)

OCU:

100352965

OPI:	101525469(RIPK1)

TUP:	102502622(RIPK1)

GVR:	103604452(RIPK1)

CFA:	102152063(RIPK1)

CLUD:

112659329(RIPK1)

VVP:	112907423(RIPK1)

VLG:	121500447(RIPK1)

NPO:	129507824(RIPK1)

AML:	100469872(RIPK1)

UMR:	103664964(RIPK1)

UAH:	113264397(RIPK1)

UAR:	123801512(RIPK1)

ELK:

111156712

LLV:

125103136

MPUF:

101685502(RIPK1)

MNP:	132018518(RIPK1)

MLK:	131834461(RIPK1)

NVS:	122912358(RIPK1)

ORO:	101363053(RIPK1)

EJU:	114223902(RIPK1)

ZCA:	113927116(RIPK1)

MLX:	118027395(RIPK1)

NSU:	110586632(RIPK1)

LWW:	102727515(RIPK1)

FCA:	101087663(RIPK1)

PYU:	121020589(RIPK1)

PCOO:

112853514(RIPK1)

PBG:	122489292(RIPK1)

PVIV:

125166031(RIPK1)

LRUF:

124529310

PTG:	102964459(RIPK1)

PPAD:

109249466(RIPK1)

PUC:

125939602

AJU:

106976163

HHV:	120241444(RIPK1)

BTA:	504727(RIPK1)

BOM:	102279783(RIPK1)

BIU:	109577264(RIPK1)

BBUB:

102399138(RIPK1)

BBIS:

105001321

CHX:	102178407(RIPK1)

OAS:	101110186(RIPK1)

BTAX:

128055992(RIPK1)

ODA:	120869963(RIPK1)

CCAD:

122429455(RIPK1)

MBEZ:

129543713(RIPK1)

SSC:	100524751(RIPK1)

CFR:	102516401(RIPK1)

CBAI:

105079771(RIPK1)

CDK:	105087344(RIPK1)

VPC:	102534952(RIPK1)

BACU:

103004292(RIPK1)

BMUS:

118903372(RIPK1)

LVE:	103079935(RIPK1)

OOR:	101289751(RIPK1)

DLE:	111181305(RIPK1)

PCAD:

102985812(RIPK1)

PSIU:

116762851(RIPK1)

NASI:

112395321(RIPK1)

ECB:	100058015(RIPK1)

EPZ:	103556321(RIPK1)

EAI:	106847888(RIPK1)

MYB:	102245425(RIPK1)

MYD:	102770973(RIPK1)

MMYO:

118675368(RIPK1)

MLF:	102425101(RIPK1)

MDT:	132230664(RIPK1)

PKL:	118724462(RIPK1)

EFUS:

103302882(RIPK1)

MNA:	107542939(RIPK1)

DRO:	112297551(RIPK1)

SHON:

118986453(RIPK1)

AJM:	119051788(RIPK1)

PDIC:

114497608(RIPK1)

PHAS:

123820769(RIPK1)

MMF:	118616944 118626388(RIPK1)

PPAM:

129085546(RIPK1)

HAI:	109396595(RIPK1)

RFQ:	117027041(RIPK1)

PALE:

102885162(RIPK1)

PGIG:

120607712(RIPK1)

PVP:	105296778(RIPK1)

RAY:	107521720(RIPK1)

MJV:	108393592(RIPK1)

TOD:	119251060(RIPK1)

SARA:

101537410(RIPK1)

SETR:

125996165(RIPK1)

LAV:	100666489(RIPK1)

TMU:

101341436

ETF:	101652750(RIPK1)

DNM:	101427202(RIPK1)

MDO:	100028597(RIPK1)

GAS:	123240537(RIPK1)

SHR:	100914177(RIPK1)

AFZ:

127544228

PCW:	110201152(RIPK1)

TVP:	118855510(RIPK1)

OAA:	100079746(RIPK1) 114805391

GGA:	378921(RIPK1)

PCOC:

116226413(RIPK1)

MGP:	100542115(RIPK1)

CJO:	107309664(RIPK1)

TPAI:

128087719(RIPK1)

LMUT:

125690929(RIPK1)

NMEL:

110392996(RIPK1)

APLA:

101801990(RIPK1)

ACYG:

106043847(RIPK1)

CATA:

118251009(RIPK1)

AFUL:

116486694(RIPK1)

TGU:	100230522(RIPK1)

LSR:	110478243(RIPK1)

SCAN:

103817591(RIPK1)

PMOA:

120497257(RIPK1)

OTC:	121340487(RIPK1)

PRUF:

121357820(RIPK1)

GFR:	102038584(RIPK1)

FAB:	101806351(RIPK1)

OMA:	130250432(RIPK1)

PHI:	102112432(RIPK1)

PMAJ:

107199939(RIPK1)

CCAE:

111923828(RIPK1)

CCW:	120409663(RIPK1)

CBRC:

103618647(RIPK1)

ETL:	114062379(RIPK1)

ZAB:	102066640(RIPK1)

ZLE:	135444142(RIPK1)

ACHL:

103799006(RIPK1)

SVG:	106850789(RIPK1)

MMEA:

130586771(RIPK1)

HRT:	120763173(RIPK1)

SATI:

136365104(RIPK1)

FPG:	101913441(RIPK1)

FCH:	102058820(RIPK1)

CCRI:

104157375

NNT:	104411630(RIPK1)

SHAB:

115615063(RIPK1)

ACUN:

113477033(RIPK1)

TALA:

104360980(RIPK1)

ACHC:

115353096(RIPK1)

HALD:

104324445(RIPK1)

HLE:	104835339(RIPK1)

AGEN:

126048669

GCL:

127012916

CSTI:

104550589(RIPK1)

LDI:	104347921(RIPK1)

MNB:	103770475(RIPK1)

DPUB:

104303200(RIPK1)

AVIT:

104268073(RIPK1)

BRHI:

104492700

EGZ:	104122827(RIPK1)

NNI:	104021840(RIPK1)

PCRI:

104024831(RIPK1)

PCAO:

104049000(RIPK1)

PADL:

103919013(RIPK1)

AFOR:

103898822(RIPK1)

FGA:	104078528(RIPK1)

GSTE:

104260433(RIPK1)

CLV:	102093314(RIPK1)

MUI:

104538113

PGUU:

104458625(RIPK1)

PLET:

104619581

EHS:	104509055(RIPK1)

CMAC:

104480789(RIPK1)

CUCA:

104066820(RIPK1)

TEO:	104373721(RIPK1)

BREG:

104629950(RIPK1)

OHA:	104333489(RIPK1)

ACAR:

104518478(RIPK1)

CPEA:

104391589(RIPK1)

CVF:	104286653(RIPK1)

RTD:	128905832(RIPK1)

AAM:	106483966(RIPK1)

AROW:

112968039(RIPK1)

NPD:	112947649(RIPK1)

TGT:

104574060

DNE:	112992029(RIPK1)

SCAM:

104146121(RIPK1)

ASN:	102367941(RIPK1)

AMJ:	102572936(RIPK1)

CPOO:

109315078(RIPK1)

GGN:	109301070(RIPK1)

PSS:

102455858

CMY:	102944603(RIPK1)

CCAY:

125632091(RIPK1)

DCC:	119851333(RIPK1)

CPIC:

101949964(RIPK1)

TST:	117873157(RIPK1)

CABI:

116835506(RIPK1)

MRV:	120396472(RIPK1)

ACS:	100556206(ripk1)

ASAO:

132774553(RIPK1)

PVT:	110077096(RIPK1)

SUND:

121929823(RIPK1)

PBI:	103062047(RIPK1)

PMUR:

107285792(RIPK1)

CTIG:

120307595(RIPK1)

TSR:	106553353(RIPK1)

PGUT:

117672432(RIPK1)

APRI:

131195765(RIPK1)

PTEX:

113445709(RIPK1)

NSS:	113417994(RIPK1)

VKO:	123020633(RIPK1)

PMUA:

114600956(RIPK1)

PRAF:

128417830(RIPK1)

ZVI:	118090528(RIPK1)

HCG:	128325425(RIPK1)

GJA:	107123834(RIPK1)

STOW:

125439120(RIPK1)

EMC:	129334095(RIPK1)

XLA:	108720077(ripk1.S) 734234(ripk1.L)

XTR:	779958(ripk1)

NPR:	108793401(RIPK1)

RTEM:

120940660(RIPK1)

BBUF:

121001072(RIPK1)

BGAR:

122938217(RIPK1)

MUO:	115475165(RIPK1)

GSH:	117355798(RIPK1)

DRE:	567460(ripk1l)

SRX:	107724045 107745885

SANH:

107671717 107685278

SGH:	107563075 107565525(ripk1) 107576848

CCAR:

109077575 109077592

CAUA:

113039554 113046192

CGIB:

127951476 128022063

PTET:

122332399(ripk1l)

LROH:

127173188(ripk1l)

OMC:	131521969(ripk1l)

PPRM:

120470021(ripk1l)

RKG:	130099777(ripk1l)

MAMB:

125250625(ripk1l)

CIDE:

127502910

CERY:

137003214(ripk1l)

MASI:

127440734 127442870

TROS:

130554348(ripk1l)

TDW:	130418194(ripk1l)

MANU:

129441497(ripk1l)

IPU:	108267903(ripk1l)

IFU:	128610427(ripk1l)

PHYP:

113547223(ripk1)

SMEO:

124387540(ripk1l)

TFD:	113662308(ripk1l)

TVC:	132848999(ripk1l)

TRN:	134312450(ripk1l)

AMEX:

103045920(ripk1l)

CMAO:

118825895(ripk1l)

EEE:	113582984(ripk1)

CHAR:

105898520(ripk1l)

TRU:	101073092(ripk1)

TFS:	130538990(ripk1l)

TNG:	GSTEN00006438G001

LCO:	104931522(ripk1)

NCC:	104943381(ripk1)

TBEN:

117488872(ripk1l)

CGOB:

115023129(ripk1)

PGEO:

117462675(ripk1l)

GACU:

117558314(ripk1l)

EMAC:

134866131(ripk1l)

ELY:	117272378(ripk1l)

EFO:	125902216(ripk1l)

PLEP:

121951905(ripk1l)

SLUC:

116046027(ripk1l)

ECRA:

117954180(ripk1l)

ESP:	116698944(ripk1)

PFLV:

114565733(ripk1)

GAT:	120815607(ripk1l)

PPUG:

119209169(ripk1l)

AFB:	129115377(ripk1l)

CLUM:

117746125(ripk1l)

PSWI:

130197941(ripk1l)

MSAM:

119902043(ripk1l)

SCHU:

122887413(ripk1l)

CUD:	121520732(ripk1l)

ALAT:

119011508(ripk1l)

MZE:	101477700(ripk1)

ONL:	100705112(ripk1)

OAU:	116318688(ripk1l)

OLA:	101167739(ripk1)

OML:	112147068(ripk1l)

CSAI:

133452764(ripk1l)

XMA:	102226461(ripk1)

XCO:	114146782(ripk1)

XHE:	116721949(ripk1)

PRET:

103479635

PFOR:

103135809(ripk1)

PLAI:

106948613(ripk1)

PMEI:

106925927(ripk1)

GAF:	122841239(ripk1l)

PPRL:

129362253(ripk1l)

CVG:	107090042(ripk1)

CTUL:

119795720(ripk1l)

GMU:	124870569(ripk1l)

NFU:	107383909(ripk1)

KMR:	108239582(ripk1l)

ALIM:

106533899(ripk1)

NWH:	119414197(ripk1l)

AOCE:

111568701(ripk1)

MCEP:

125011224(ripk1l)

CSEM:

103396277(ripk1)

POV:	109645932(ripk1)

SSEN:

122777872(ripk1l)

HHIP:

117778363(ripk1l)

HSP:	118117970(ripk1l)

PPLT:

128454006(ripk1l)

SMAU:

118310776(ripk1l)

LCF:	108883409(ripk1l)

SDU:	111231266(ripk1)

SLAL:

111670509(ripk1)

XGL:	120799349(ripk1l)

HCQ:	109521234(ripk1)

SSCV:

125984782

SBIA:

133510925(ripk1l)

PEE:	133411178(ripk1l)

PTAO:

133489522(ripk1l)

BPEC:

110158624(ripk1)

MALB:

109957635(ripk1)

BSPL:

114845086(ripk1l)

SJO:	128369224(ripk1l)

SASA:

106569156(ripk1) 106599735

STRU:

115157139(ripk1) 115169632

OTW:	112226835 112260583

OMY:	110508625 110530438

OGO:	124010072 124041770

ONE:	115102987 115114526

OKI:	109871759 109883234

OKE:	118394771 118402001

SALP:

111956264 111979659

SNH:	120020295 120055574

CCLU:

121535318 121581011

ELS:	105018575(ripk1)

SFM:	108937518 108939327(ripk1)

PKI:	111845914(ripk1)

AANG:

118226129 118234395(ripk1l)

LOC:	102691146(ripk1)

PSPA:

121314593(ripk1l)

ARUT:

117394623(ripk1l)

PSEX:

120529549(ripk1l)

LCM:	102363596(RIPK1)

CMK:	103176210(ripk1l)

RTP:	109931682(ripk1l)

CPLA:

122564495(ripk1l)

HOC:	132832326(ripk1l)

LERI:

129708079(ripk1l)

PMRN:

116944216(RIPK1)

LRJ:

133350918

BFO:

118418091

BBEL:

109468836 109473249 109473670 109477000

CIN:	100184684 100186073

SCLV:

120336550 120338289

APLC:

110987573

ARUN:

117302708

SKO:	100368709 102802386

GAE:

HRF:

HRJ:

PMAX:

LAK:	106164324 106173999

LLON:

ATEN:

XEN:

Reference

PMID:19524513

Authors

Cho YS, Challa S, Moquin D, Genga R, Ray TD, Guildford M, Chan FK

Title

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation.

Journal

Cell 137:1112-23 (2009)
DOI:10.1016/j.cell.2009.05.037

Reference

PMID:8612133

Authors

Hsu H, Huang J, Shu HB, Baichwal V, Goeddel DV

Title

TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex.

Journal

Immunity 4:387-96 (1996)
DOI:10.1016/S1074-7613(00)80252-6

Sequence

[hsa:8737]

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Ontology (3)   
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Pathway (32)   
   KEGG PATHWAY (32)   
Disease (2)   
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Chemical reaction (1)   
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Gene (587)   
   KEGG GENES (446)   
   KEGG MGENES (80)   
   RefGene (58)   
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