KEGG   ORTHOLOGY: K03066
Entry
K03066                      KO                                     

Name
PSMC5, RPT6
Definition
26S proteasome regulatory subunit T6
Pathway
ko03050  Proteasome
ko05010  Alzheimer disease
ko05012  Parkinson disease
ko05016  Huntington disease
ko05017  Spinocerebellar ataxia
ko05169  Epstein-Barr virus infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    K03066  PSMC5, RPT6; 26S proteasome regulatory subunit T6
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K03066  PSMC5, RPT6; 26S proteasome regulatory subunit T6
   05012 Parkinson disease
    K03066  PSMC5, RPT6; 26S proteasome regulatory subunit T6
   05016 Huntington disease
    K03066  PSMC5, RPT6; 26S proteasome regulatory subunit T6
   05017 Spinocerebellar ataxia
    K03066  PSMC5, RPT6; 26S proteasome regulatory subunit T6
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    K03066  PSMC5, RPT6; 26S proteasome regulatory subunit T6
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome
    K03066  PSMC5, RPT6; 26S proteasome regulatory subunit T6
Proteasome [BR:ko03051]
 Eukaryotic proteasome
  Regulatory particles
   PA700 (19S proteasome)
    ATPase subunits
     K03066  PSMC5, RPT6; 26S proteasome regulatory subunit T6
Other DBs
COG: COG1222
Genes
HSA: 5705(PSMC5)
PTR: 454777(PSMC5)
PPS: 100969119(PSMC5)
GGO: 101153929(PSMC5)
PON: 100174487(PSMC5)
NLE: 100587421(PSMC5)
MCC: 717437(PSMC5)
MCF: 101865051(PSMC5)
CSAB: 103243218(PSMC5)
RRO: 104675461(PSMC5)
RBB: 108536276(PSMC5)
CJC: 100392176(PSMC5)
SBQ: 101037999(PSMC5)
MMU: 19184(Psmc5)
MCAL: 110305768(Psmc5)
MPAH: 110331458(Psmc5)
RNO: 81827(Psmc5)
MUN: 110547029(Psmc5)
CGE: 100771099(Psmc5)
NGI: 103744750(Psmc5)
HGL: 101710432(Psmc5)
CCAN: 109700522(Psmc5)
OCU: 100349785(PSMC5)
TUP: 102474495(PSMC5)
CFA: 480478(PSMC5)
VVP: 112920708(PSMC5)
AML: 100471784(PSMC5)
UMR: 103665634(PSMC5)
UAH: 113265286(PSMC5)
ORO: 101372591(PSMC5)
ELK: 111158036
FCA: 101097360(PSMC5)
PTG: 102951790(PSMC5)
PPAD: 109277101(PSMC5)
AJU: 106978694(PSMC5)
BTA: 282015(PSMC5)
BOM: 102273025(PSMC5)
BIU: 109573392(PSMC5)
BBUB: 102407673(PSMC5)
CHX: 102176071(PSMC5)
OAS: 101104076(PSMC5)
SSC: 397043(PSMC5)
CFR: 102517432(PSMC5)
CDK: 105090405(PSMC5)
BACU: 103018659(PSMC5)
LVE: 103076910(PSMC5)
OOR: 101290309(PSMC5)
DLE: 111182616(PSMC5)
PCAD: 102983885(PSMC5)
ECB: 100053987(PSMC5)
EPZ: 103549759(PSMC5)
EAI: 106835533(PSMC5)
MYB: 102248075(PSMC5)
MYD: 102751479(PSMC5)
MNA: 107530659(PSMC5)
HAI: 109380274(PSMC5)
DRO: 112316274(PSMC5)
PALE: 102898429(PSMC5)
RAY: 107501981(PSMC5)
MJV: 108403034(PSMC5)
LAV: 100669867(PSMC5)
TMU: 101353736
MDO: 100026270(PSMC5)
SHR: 100922728(PSMC5)
PCW: 110215691(PSMC5)
OAA: 114815139(PSMC5)
GGA: 428274(PSMC5)
MGP: 100539380(PSMC5)
CJO: 107325047(PSMC5)
NMEL: 110388505(PSMC5)
APLA: 101796184(PSMC5)
ACYG: 106046899(PSMC5)
TGU: 100190703(PSMC5)
LSR: 110479571(PSMC5)
SCAN: 103821676(PSMC5)
GFR: 102043870(PSMC5)
FAB: 101808442(PSMC5)
PHI: 102099915(PSMC5)
PMAJ: 107215286(PSMC5)
CCAE: 111921992(PSMC5)
ETL: 114069179(PSMC5)
FPG: 101910878(PSMC5)
FCH: 102049646(PSMC5)
CLV: 102090008(PSMC5)
EGZ: 104132273(PSMC5)
NNI: 104012267(PSMC5)
ACUN: 113489067(PSMC5)
AAM: 106497455(PSMC5)
ASN: 102370047(PSMC5)
AMJ: 102566117(PSMC5)
PSS: 102461599(PSMC5)
CMY: 102944347(PSMC5)
CPIC: 101939629(PSMC5)
ACS: 100565316(psmc5)
PVT: 110074878(PSMC5)
PBI: 103052444(PSMC5)
PMUR: 107303104(PSMC5)
TSR: 106551067(PSMC5)
PMUA: 114582259(PSMC5)
GJA: 107125658(PSMC5)
XLA: 397968(psmc5.S) 443908(psmc5.L)
XTR: 394988(psmc5)
NPR: 108790552(PSMC5)
DRE: 445285(psmc5)
SGH: 107560539(psmc5) 107569174
IPU: 100528935(prs8) 108273579(psmc5)
PHYP: 113547462(psmc5)
AMEX: 103027731(psmc5)
EEE: 113576881(psmc5)
LCO: 104930394(psmc5)
NCC: 104953578(psmc5)
MZE: 101484332(psmc5)
ONL: 100690634(psmc5)
OLA: 101158979(psmc5)
XMA: 102222039(psmc5)
XCO: 114152307(psmc5)
PRET: 103481340(psmc5)
CVG: 107085065(psmc5)
NFU: 107387915(psmc5)
KMR: 108246526(psmc5)
ALIM: 106521395(psmc5)
POV: 109627039(psmc5)
LCF: 108873432(psmc5)
SDU: 111219737(psmc5)
SLAL: 111652254(psmc5)
HCQ: 109523934(psmc5)
BPEC: 110170990(psmc5)
MALB: 109963094(psmc5)
SASA: 100196219(prs8) 106579096
ELS: 105006186(psmc5)
SFM: 108919373(psmc5)
PKI: 111834429(psmc5)
LCM: 102348506(PSMC5)
CMK: 103183837(psmc5)
RTP: 109927329(psmc5)
CIN: 100184778
APLC: 110973424
SKO: 100371302
DME: Dmel_CG1489(Rpt6) Dmel_CG2241(Rpt6R)
DSI: Dsimw501_GD16958(Dsim_GD16958) Dsimw501_GD17527(Dsim_GD17527)
DWI: 6644525
MDE: 101889234
LCQ: 111677147
AAG: 5565085
AME: 550794
BIM: 100745238
BTER: 100643819
CCAL: 108631263
OBB: 114872406
SOC: 105201960
MPHA: 105837795
AEC: 105149303
PBAR: 105427755
VEM: 105561600
HST: 105192302
DQU: 106747068
CFO: 105253885
LHU: 105672081
PGC: 109853516
OBO: 105281690
PCF: 106789260
NVI: 100114873
CSOL: 105361899
MDL: 103569743
TCA: 661287
DPA: 109541989
ATD: 109604977
NVL: 108560178
BMOR: 101747034
BMAN: 114247856
PMAC: 106717390
PRAP: 111000379
HAW: 110383163
PXY: 105388753
API: 100165202
DNX: 107166028
RMD: 113555492
BTAB: 109031162
CLEC: 106669302
ZNE: 110828510
FCD: 110853827
PVM: 113803529
TUT: 107362461
PTEP: 107436316
CEL: CELE_F56F11.4(F56F11.4) CELE_Y49E10.1(rpt-6)
TSP: Tsp_06519
PCAN: 112563695
CRG: 105334244
MYI: 110465010
OBI: 106869833
LAK: 106162073
SHX: MS3_11217
NVE: 5521715
ADF: 107339508
AMIL: 114965757
PDAM: 113664733
SPIS: 111332724
AQU: 100636016
ATH: AT5G19990(RPT6A) AT5G20000
CPAP: 110825879
CIT: 102610684
TCC: 18588693
EGR: 104438493
VRA: 106773956
VAR: 108320654
VUN: 114167012
CCAJ: 109808502
LJA: Lj3g3v2038730.1(Lj3g3v2038730.1)
FVE: 101312376
RCN: 112186662
PMUM: 103341010
ZJU: 107432394
RCU: 8276221
JCU: 105639306
CANN: 107877918(RPT6)
DOSA: Os02t0205300-01(Os02g0205300) Os06t0600100-01(Os06g0600100)
ATS: 109751981(LOC109751981) 109766436(LOC109766436)
ZMA: 100273032 100274445(TIDP2690)
CRE: CHLREDRAFT_24536(RPT6)
VCN: VOLCADRAFT_104963(rpt6)
MNG: MNEG_5944
APRO: F751_1845
SCE: YGL048C(RPT6)
KMX: KLMA_50143(RPT6)
NCS: NCAS_0A05880(NCAS0A05880)
NDI: NDAI_0D02850(NDAI0D02850)
TPF: TPHA_0F00440(TPHA0F00440)
TBL: TBLA_0B09880(TBLA0B09880)
TDL: TDEL_0E05660(TDEL0E05660)
KAF: KAFR_0F03100(KAFR0F03100)
PIC: PICST_71824(RPT6)
CAL: CAALFM_C208780WA(RPT6)
SLB: AWJ20_2555(RPT6)
NCR: NCU05363
NTE: NEUTE1DRAFT117508(NEUTE1DRAFT_117508)
MGR: MGG_01380
SSCK: SPSK_02581
NHE: NECHADRAFT_65127(PATPB2101)
MAW: MAC_02779
MAJ: MAA_08566
CMT: CCM_02191
BFU: BCIN_02g02920(Bcrpt6)
MBE: MBM_05538
ANI: AN6988.2
ANG: ANI_1_32124(An14g00180)
ABE: ARB_06017
TVE: TRV_01185
PTE: PTT_14578
ZTR: MYCGRDRAFT_99610(PATPB2401)
SPO: SPBC23G7.12c(rpt6)
CNE: CNJ01000
CNB: CNBJ2480
TASA: A1Q1_06353
LBC: LACBIDRAFT_191308(PATPB16201)
ABP: AGABI1DRAFT115807(AGABI1DRAFT_115807)
ABV: AGABI2DRAFT194450(AGABI2DRAFT_194450)
MGL: MGL_0676
MRT: MRET_2549
DDI: DDB_G0292382(psmC5)
DFA: DFA_11881(psmC5)
EHI: EHI_160570 EHI_185410(345.t00012) EHI_187600
PCB: PCHAS_146410(PC000520.02.0)
TAN: TA15700
TPV: TP02_0893
BBO: BBOV_I000480(16.m00708)
CPV: cgd6_920
SMIN: v1.2.012125.t1(symbB.v1.2.012125.t1)
TPS: THAPSDRAFT_32037(RPT6)
SPAR: SPRG_01475
LMA: LMJF_36_4360(RPT6)
LIF: LINJ_36_4570(RPT6)
LBZ: LBRM_35_4600(RPT6)
LPAN: LPMP_354470(RPT6)
 » show all
Reference
PMID:7729537
  Authors
Akiyama K, Yokota K, Kagawa S, Shimbara N, DeMartino GN, Slaughter CA, Noda C, Tanaka K
  Title
cDNA cloning of a new putative ATPase subunit p45 of the human 26S proteasome, a homolog of yeast transcriptional factor Sug1p.
  Journal
FEBS Lett 363:151-6 (1995)
DOI:10.1016/0014-5793(95)00304-R
  Sequence
[hsa:5705]
Reference
  Authors
Bhat KP, Turner JD, Myers SE, Cape AD, Ting JP, Greer SF
  Title
The 19S proteasome ATPase Sug1 plays a critical role in regulating MHC class II transcription.
  Journal
Mol Immunol 45:2214-24 (2008)
DOI:10.1016/j.molimm.2007.12.001
  Sequence
[hsa:5705]
Reference
  Authors
Gillette TG, Kumar B, Thompson D, Slaughter CA, DeMartino GN
  Title
Differential roles of the COOH termini of AAA subunits of PA700 (19 S regulator) in asymmetric assembly and activation of the 26 S proteasome.
  Journal
J Biol Chem 283:31813-22 (2008)
DOI:10.1074/jbc.M805935200

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