KEGG   ORTHOLOGY: K03084
Entry
K03084                      KO                                     

Name
SHIP1, INPP5D
Definition
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [EC:3.1.3.86]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko04070  Phosphatidylinositol signaling system
ko04662  B cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K03084  SHIP1, INPP5D; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
 09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    K03084  SHIP1, INPP5D; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
 09150 Organismal Systems
  09151 Immune system
   04662 B cell receptor signaling pathway
    K03084  SHIP1, INPP5D; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
   04664 Fc epsilon RI signaling pathway
    K03084  SHIP1, INPP5D; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
   04666 Fc gamma R-mediated phagocytosis
    K03084  SHIP1, INPP5D; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K03084  SHIP1, INPP5D; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.86  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
     K03084  SHIP1, INPP5D; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
Membrane trafficking [BR:ko04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    K03084  SHIP1, INPP5D; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
Other DBs
RN: R09827
GO: 0034485
Genes
HSA: 3635(INPP5D)
PTR: 470683(INPP5D)
PPS: 100988546(INPP5D)
GGO: 101142949(INPP5D)
PON: 100446045(INPP5D)
NLE: 100598985(INPP5D)
MCC: 717832(INPP5D)
MCF: 102134197(INPP5D)
CSAB: 103218100(INPP5D)
RRO: 104654059(INPP5D)
RBB: 108520096(INPP5D)
CJC: 100400043(INPP5D)
SBQ: 101051962(INPP5D)
MMU: 16331(Inpp5d)
MCAL: 110289786(Inpp5d)
MPAH: 110321564(Inpp5d)
RNO: 54259(Inpp5d)
MUN: 110552950(Inpp5d)
CGE: 100764735(Inpp5d)
NGI: 103738235(Inpp5d)
HGL: 101711777(Inpp5d)
CCAN: 109695964(Inpp5d)
OCU: 103347299 103352489(INPP5D)
TUP: 102487042(INPP5D)
CFA: 100688270(INPP5D)
VVP: 112925489(INPP5D)
AML: 100464150(INPP5D)
UMR: 103662839(INPP5D)
UAH: 113250332(INPP5D)
ORO: 101378132(INPP5D)
ELK: 111153162
FCA: 101100500(INPP5D)
PTG: 102971986(INPP5D)
PPAD: 109264887(INPP5D)
AJU: 106975888(INPP5D)
BTA: 507329(INPP5D)
BOM: 102266365(INPP5D)
BIU: 109556542
BBUB: 102395550(INPP5D)
CHX: 102170935(INPP5D)
OAS: 101112941(INPP5D)
SSC: 100526019(INPP5D)
CFR: 102506956(INPP5D)
CDK: 105105239(INPP5D)
BACU: 103008465(INPP5D)
LVE: 103091136(INPP5D)
OOR: 101279600(INPP5D)
DLE: 111172131(INPP5D)
PCAD: 102994496(INPP5D)
ECB: 100064896(INPP5D)
EPZ: 103555980(INPP5D)
EAI: 106844848(INPP5D)
MYB: 102240810(INPP5D)
MYD: 102769498(INPP5D)
MNA: 107530717(INPP5D)
HAI: 109375054(INPP5D)
DRO: 112307792(INPP5D)
PALE: 102882532(INPP5D)
RAY: 107504998(INPP5D)
LAV: 100664012(INPP5D)
TMU: 101350772
MDO: 100021361(INPP5D)
SHR: 100916136(INPP5D)
PCW: 110198022(INPP5D)
OAA: 100092282(INPP5D)
GGA: 424745(INPP5D)
MGP: 100549631(INPP5D)
CJO: 107317932(INPP5D)
NMEL: 110398040(INPP5D)
APLA: 101797866(INPP5D)
ACYG: 106040262(INPP5D)
TGU: 100219581(INPP5D)
LSR: 110478041(INPP5D)
SCAN: 103815664(INPP5D)
GFR: 102043433(INPP5D)
FAB: 101809542(INPP5D)
PHI: 102105757(INPP5D)
PMAJ: 107208645(INPP5D)
CCAE: 111933678(INPP5D)
CCW: 104683678(INPP5D)
ETL: 114054839(INPP5D)
FPG: 101923853(INPP5D)
FCH: 102056843(INPP5D)
CLV: 102095796(INPP5D)
EGZ: 104126900(INPP5D)
NNI: 104008603(INPP5D)
ACUN: 113483695(INPP5D)
PADL: 103912729(INPP5D)
AAM: 106484450(INPP5D)
ASN: 102380530(INPP5D)
AMJ: 102572303(INPP5D)
PSS: 102462454(INPP5D)
CMY: 102935566(INPP5D)
CPIC: 101950741(INPP5D)
ACS: 100561031(inpp5d)
PVT: 110075830(INPP5D)
PBI: 103050036(INPP5D)
PMUR: 107285512(INPP5D)
TSR: 106550701(INPP5D)
PMUA: 114597655(INPP5D)
GJA: 107123574(INPP5D)
XLA: 108718174(inpp5d.S) 399051(inpp5d.L)
XTR: 100497417(inpp5d)
NPR: 108796209(INPP5D)
DRE: 559103(inpp5d)
CCAR: 109110360
IPU: 108272096(inpp5d)
PHYP: 113529181(inpp5d)
AMEX: 103032277(inpp5d)
EEE: 113575910(inpp5d)
TRU: 101079472(inpp5d)
LCO: 104925824(inpp5d)
NCC: 104965434
MZE: 101476435(inpp5d)
ONL: 100694140(inpp5d)
OLA: 101163652(inpp5d)
XMA: 102221920(inpp5d)
XCO: 114151307(inpp5d)
PRET: 103463941(inpp5d)
CVG: 107088679(inpp5d)
NFU: 107387410(inpp5d)
KMR: 108240225(inpp5d)
ALIM: 106527460(inpp5d)
AOCE: 111565027(inpp5d)
CSEM: 103399950(inpp5d)
POV: 109625285(inpp5d)
LCF: 108878870(inpp5d)
SDU: 111231975(inpp5d)
SLAL: 111669582(inpp5d)
HCQ: 109532322(inpp5d)
BPEC: 110154735(inpp5d)
MALB: 109965768(inpp5d)
SASA: 100380693(ship1) 106560606
ELS: 105029544(inpp5d)
SFM: 108937425(inpp5d)
PKI: 111837595(inpp5d)
LCM: 102365596(INPP5D)
CMK: 103185799(inpp5d)
RTP: 109914977(inpp5d)
DFA: DFA_08125(Dd5P1)
 » show all
Reference
PMID:8769125
  Authors
Drayer AL, Pesesse X, De Smedt F, Woscholski R, Parker P, Erneux C
  Title
Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase.
  Journal
Biochem Biophys Res Commun 225:243-9 (1996)
DOI:10.1006/bbrc.1996.1161
  Sequence
[hsa:3635]

KEGG   ORTHOLOGY: K15909
Entry
K15909                      KO                                     

Name
SHIP2, INPPL1
Definition
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 [EC:3.1.3.86]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko04070  Phosphatidylinositol signaling system
ko04662  B cell receptor signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04910  Insulin signaling pathway
Disease
H01828  Opsismodysplasia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
 09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
 09150 Organismal Systems
  09151 Immune system
   04662 B cell receptor signaling pathway
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
   04666 Fc gamma R-mediated phagocytosis
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
  09152 Endocrine system
   04910 Insulin signaling pathway
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.86  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
     K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
Membrane trafficking [BR:ko04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Inositol 5-phosphatases
    K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
Other DBs
RN: R09827
GO: 0034485
Genes
HSA: 3636(INPPL1)
PTR: 451403(INPPL1)
PPS: 100992766(INPPL1)
GGO: 101127569(INPPL1)
PON: 100450015(INPPL1)
NLE: 100596562(INPPL1)
MCC: 718421(INPPL1)
MCF: 102115401(INPPL1)
CSAB: 103247996(INPPL1)
RRO: 104665152(INPPL1)
RBB: 108543771(INPPL1)
CJC: 100396447(INPPL1)
SBQ: 101029956(INPPL1)
MMU: 16332(Inppl1)
MCAL: 110297343(Inppl1)
MPAH: 110329610(Inppl1)
RNO: 65038(Inppl1)
MUN: 110550789(Inppl1)
CGE: 100772102(Inppl1)
NGI: 103750804(Inppl1)
HGL: 101698814(Inppl1)
CCAN: 109693012(Inppl1)
OCU: 100339369(INPPL1)
TUP: 102485077(INPPL1)
CFA: 485209(INPPL1)
VVP: 112928740(INPPL1)
AML: 100482460(INPPL1)
UMR: 103678107(INPPL1)
UAH: 113269258(INPPL1)
ORO: 101366414(INPPL1)
ELK: 111159402
FCA: 101095611(INPPL1)
PTG: 102956183(INPPL1)
PPAD: 109267136(INPPL1)
AJU: 106970927(INPPL1)
BTA: 783833(INPPL1)
BOM: 102278222(INPPL1)
BIU: 109569627(INPPL1)
BBUB: 102402942(INPPL1)
CHX: 102178924(INPPL1)
OAS: 101121707(INPPL1)
SSC: 100462718(INPPL1)
CFR: 102509164(INPPL1)
CDK: 105096747(INPPL1)
BACU: 102999607(INPPL1)
LVE: 103078405(INPPL1)
OOR: 101269414(INPPL1)
DLE: 111170564(INPPL1)
PCAD: 102993697(INPPL1)
ECB: 100066037(INPPL1)
EPZ: 103549328(INPPL1)
EAI: 106831625(INPPL1)
MYB: 102248134(INPPL1)
MYD: 102755641(INPPL1)
MNA: 107533662(INPPL1)
HAI: 109372436(INPPL1)
DRO: 112315920(INPPL1)
PALE: 102890098(INPPL1)
RAY: 107517370(INPPL1)
MJV: 108405095(INPPL1)
LAV: 100673994(INPPL1)
TMU: 101351608
MDO: 100015500(INPPL1)
SHR: 100930081(INPPL1)
PCW: 110195040(INPPL1)
OAA: 100088229(INPPL1)
GGA: 428692(INPPL1)
MGP: 100540799
CJO: 107312645
NMEL: 110391676(INPPL1) 110403391
ACYG: 106042953(INPPL1)
TGU: 100222691 100222899(INPPL1)
LSR: 110473122(INPPL1) 110474379
SCAN: 103816565 103820748(INPPL1)
GFR: 102032471(INPPL1) 102036900
FAB: 101807549(INPPL1) 101820739
PHI: 102101537 102102439(INPPL1)
PMAJ: 107203647 107212504(INPPL1)
CCAE: 111928734 111943484(INPPL1)
CCW: 104687164(INPPL1) 104691345
ETL: 114059614(INPPL1) 114065162
FPG: 101918373(INPPL1) 101919963
FCH: 102048151 102056978(INPPL1)
CLV: 102083667(INPPL1) 102085697
EGZ: 104135987
NNI: 104011872(INPPL1) 104012926
PADL: 103919205
AAM: 106486171(INPPL1)
ASN: 102375443 102388319(INPPL1)
AMJ: 102563685(INPPL1) 102576763
PSS: 102448035(INPPL1) 102448772
CMY: 102929300 102929354(INPPL1)
CPIC: 101932232(INPPL1) 101951468
ACS: 100556812(inppl1)
PVT: 110078090(INPPL1)
PBI: 103051579(INPPL1)
TSR: 106553455(INPPL1)
PMUA: 114595500(INPPL1)
XLA: 108698315 108708768(inppl1.L)
XTR: 100485745(inppl1) 100496685
NPR: 108785616 108801007(INPPL1)
DRE: 325179(inppl1a) 368433(inppl1b)
IPU: 108261207(SHIP-2) 108268863(inppl1b) 108277646(inppl1)
PHYP: 113529332 113544603(inppl1)
AMEX: 103026127 103027088(inppl1)
EEE: 113581578(inppl1) 113582441
TRU: 101065901(inppl1) 101069844
LCO: 104920140(inppl1) 104923483
NCC: 104958004 104968285(inppl1)
MZE: 101483507(inppl1) 101484941
ONL: 100705507(inppl1) 100706013
OLA: 101165747(inppl1) 101168299
XMA: 102222770 102228371(inppl1)
XCO: 114133153(inppl1) 114139388
PRET: 103471620 103474471(inppl1)
CVG: 107091942(inppl1) 107102648
NFU: 107378661 107380469(inppl1)
KMR: 108231420 108240501(inppl1)
ALIM: 106515304 106517268(inppl1)
AOCE: 111570870(inppl1) 111579643
CSEM: 103378565(inppl1) 103390762
POV: 109625236 109634550(inppl1)
LCF: 108872540 108886606(inppl1)
SDU: 111224118(inppl1) 111232670
SLAL: 111655298(inppl1) 111666355
HCQ: 109516555 109525465(inppl1)
BPEC: 110158855 110174275(inppl1)
MALB: 109957514 109970550(inppl1)
ELS: 105029605(inppl1)
SFM: 108923188 108932224(inppl1)
PKI: 111833861(inppl1) 111835066
LCM: 102351582 102361839(INPPL1)
CMK: 103179101(inppl1)
RTP: 109914528(inppl1) 109927453
APLC: 110981025
PCAN: 112555824
CRG: 105320686
MYI: 110463198
OBI: 106880499
LAK: 106158330
NVE: 5515466
EPA: 110241032
ADF: 107355719
AMIL: 114953961
PDAM: 113672378
SPIS: 111330862
DGT: 114523455
HMG: 100212864
AQU: 100641488
 » show all
Reference
PMID:9660833
  Authors
Habib T, Hejna JA, Moses RE, Decker SJ
  Title
Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein.
  Journal
J Biol Chem 273:18605-9 (1998)
DOI:10.1074/jbc.273.29.18605
  Sequence
[hsa:3636]

KEGG   ENZYME: 3.1.3.86
Entry
EC 3.1.3.86                 Enzyme                                 

Name
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase;
SHIP1;
SHIP2;
SHIP;
p150Ship
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase
Reaction(IUBMB)
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate [RN:R09827]
Reaction(KEGG)
R09827
Substrate
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [CPD:C05981];
H2O [CPD:C00001]
Product
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate [CPD:C11554];
phosphate [CPD:C00009]
Comment
This enzyme hydrolyses 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. The enzyme also shows activity toward (PtdIns(1,3,4,5)P4) [5]. The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects.
History
EC 3.1.3.86 created 2011
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K03084  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
K15909  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
Genes
HSA: 3635(INPP5D) 3636(INPPL1)
PTR: 451403(INPPL1) 470683(INPP5D)
PPS: 100988546(INPP5D) 100992766(INPPL1)
GGO: 101127569(INPPL1) 101142949(INPP5D)
PON: 100446045(INPP5D) 100450015(INPPL1)
NLE: 100596562(INPPL1) 100598985(INPP5D)
MCC: 717832(INPP5D) 718421(INPPL1)
MCF: 102115401(INPPL1) 102134197(INPP5D)
CSAB: 103218100(INPP5D) 103247996(INPPL1)
RRO: 104654059(INPP5D) 104665152(INPPL1)
RBB: 108520096(INPP5D) 108543771(INPPL1)
CJC: 100396447(INPPL1) 100400043(INPP5D)
SBQ: 101029956(INPPL1) 101051962(INPP5D)
MMU: 16331(Inpp5d) 16332(Inppl1)
MCAL: 110289786(Inpp5d) 110297343(Inppl1)
MPAH: 110321564(Inpp5d) 110329610(Inppl1)
RNO: 54259(Inpp5d) 65038(Inppl1)
MUN: 110550789(Inppl1) 110552950(Inpp5d)
CGE: 100764735(Inpp5d) 100772102(Inppl1)
NGI: 103738235(Inpp5d) 103750804(Inppl1)
HGL: 101698814(Inppl1) 101711777(Inpp5d)
CCAN: 109693012(Inppl1) 109695964(Inpp5d)
OCU: 100339369(INPPL1) 103347299 103352489(INPP5D)
TUP: 102485077(INPPL1) 102487042(INPP5D)
CFA: 100688270(INPP5D) 485209(INPPL1)
VVP: 112925489(INPP5D) 112928740(INPPL1)
AML: 100464150(INPP5D) 100482460(INPPL1)
UMR: 103662839(INPP5D) 103678107(INPPL1)
UAH: 113250332(INPP5D) 113269258(INPPL1)
ORO: 101366414(INPPL1) 101378132(INPP5D)
FCA: 101095611(INPPL1) 101100500(INPP5D)
PTG: 102956183(INPPL1) 102971986(INPP5D)
PPAD: 109264887(INPP5D) 109267136(INPPL1)
AJU: 106970927(INPPL1) 106975888(INPP5D)
BTA: 507329(INPP5D) 783833(INPPL1)
BOM: 102266365(INPP5D) 102278222(INPPL1)
BIU: 109556542 109569627(INPPL1)
BBUB: 102395550(INPP5D) 102402942(INPPL1)
CHX: 102170935(INPP5D) 102178924(INPPL1)
OAS: 101112941(INPP5D) 101121707(INPPL1)
SSC: 100462718(INPPL1) 100526019(INPP5D)
CFR: 102506956(INPP5D) 102509164(INPPL1)
CDK: 105096747(INPPL1) 105105239(INPP5D)
BACU: 102999607(INPPL1) 103008465(INPP5D)
LVE: 103078405(INPPL1) 103091136(INPP5D)
OOR: 101269414(INPPL1) 101279600(INPP5D)
DLE: 111170564(INPPL1) 111172131(INPP5D)
PCAD: 102993697(INPPL1) 102994496(INPP5D)
ECB: 100064896(INPP5D) 100066037(INPPL1)
EPZ: 103549328(INPPL1) 103555980(INPP5D)
EAI: 106831625(INPPL1) 106844848(INPP5D)
MYB: 102240810(INPP5D) 102248134(INPPL1)
MYD: 102755641(INPPL1) 102769498(INPP5D)
MNA: 107530717(INPP5D) 107533662(INPPL1)
HAI: 109372436(INPPL1) 109375054(INPP5D)
DRO: 112307792(INPP5D) 112315920(INPPL1)
PALE: 102882532(INPP5D) 102890098(INPPL1)
RAY: 107504998(INPP5D) 107517370(INPPL1)
MJV: 108405095(INPPL1)
LAV: 100664012(INPP5D) 100673994(INPPL1)
MDO: 100015500(INPPL1) 100021361(INPP5D)
SHR: 100916136(INPP5D) 100930081(INPPL1)
PCW: 110195040(INPPL1) 110198022(INPP5D)
OAA: 100088229(INPPL1) 100092282(INPP5D)
GGA: 424745(INPP5D) 428692(INPPL1)
MGP: 100540799 100549631(INPP5D)
CJO: 107312645 107317932(INPP5D)
NMEL: 110391676(INPPL1) 110398040(INPP5D) 110403391
APLA: 101797866(INPP5D)
ACYG: 106040262(INPP5D) 106042953(INPPL1)
TGU: 100219581(INPP5D) 100222691 100222899(INPPL1)
LSR: 110473122(INPPL1) 110474379 110478041(INPP5D)
SCAN: 103815664(INPP5D) 103816565 103820748(INPPL1)
GFR: 102032471(INPPL1) 102036900 102043433(INPP5D)
FAB: 101807549(INPPL1) 101809542(INPP5D) 101820739
PHI: 102101537 102102439(INPPL1) 102105757(INPP5D)
PMAJ: 107203647 107208645(INPP5D) 107212504(INPPL1)
CCAE: 111928734 111933678(INPP5D) 111943484(INPPL1)
CCW: 104683678(INPP5D) 104687164(INPPL1) 104691345
ETL: 114054839(INPP5D) 114059614(INPPL1) 114065162
FPG: 101918373(INPPL1) 101919963 101923853(INPP5D)
FCH: 102048151 102056843(INPP5D) 102056978(INPPL1)
CLV: 102083667(INPPL1) 102085697 102095796(INPP5D)
EGZ: 104126900(INPP5D) 104135987
NNI: 104008603(INPP5D) 104011872(INPPL1) 104012926
ACUN: 113483695(INPP5D)
PADL: 103912729(INPP5D) 103919205
AAM: 106484450(INPP5D) 106486171(INPPL1)
ASN: 102375443 102380530(INPP5D) 102388319(INPPL1)
AMJ: 102563685(INPPL1) 102572303(INPP5D) 102576763
PSS: 102448035(INPPL1) 102448772 102462454(INPP5D)
CMY: 102929300 102929354(INPPL1) 102935566(INPP5D)
CPIC: 101932232(INPPL1) 101950741(INPP5D) 101951468
ACS: 100556812(inppl1) 100561031(inpp5d)
PVT: 110075830(INPP5D) 110078090(INPPL1)
PBI: 103050036(INPP5D) 103051579(INPPL1)
PMUR: 107285512(INPP5D)
TSR: 106550701(INPP5D) 106553455(INPPL1)
PMUA: 114595500(INPPL1) 114597655(INPP5D)
GJA: 107123574(INPP5D)
XLA: 108698315 108708768(inppl1.L) 108718174(inpp5d.S) 399051(inpp5d.L)
XTR: 100485745(inppl1) 100496685 100497417(inpp5d)
NPR: 108785616 108796209(INPP5D) 108801007(INPPL1)
DRE: 325179(inppl1a) 368433(inppl1b) 559103(inpp5d)
IPU: 108261207(SHIP-2) 108268863(inppl1b) 108272096(inpp5d) 108277646(inppl1)
PHYP: 113529181(inpp5d) 113529332 113544603(inppl1)
AMEX: 103026127 103027088(inppl1) 103032277(inpp5d)
EEE: 113575910(inpp5d) 113581578(inppl1) 113582441
TRU: 101065901(inppl1) 101069844 101079472(inpp5d)
LCO: 104920140(inppl1) 104923483 104925824(inpp5d)
MZE: 101476435(inpp5d) 101483507(inppl1) 101484941
ONL: 100694140(inpp5d) 100705507(inppl1) 100706013
OLA: 101163652(inpp5d) 101165747(inppl1) 101168299
XMA: 102221920(inpp5d) 102222770 102228371(inppl1)
XCO: 114133153(inppl1) 114139388 114151307(inpp5d)
PRET: 103463941(inpp5d) 103471620 103474471(inppl1)
CVG: 107088679(inpp5d) 107091942(inppl1) 107102648
NFU: 107378661 107380469(inppl1) 107387410(inpp5d)
KMR: 108231420 108240225(inpp5d) 108240501(inppl1)
ALIM: 106515304 106517268(inppl1) 106527460(inpp5d)
AOCE: 111565027(inpp5d) 111570870(inppl1) 111579643
CSEM: 103378565(inppl1) 103390762 103399950(inpp5d)
POV: 109625236 109625285(inpp5d) 109634550(inppl1)
LCF: 108872540 108878870(inpp5d) 108886606(inppl1)
SDU: 111224118(inppl1) 111231975(inpp5d) 111232670
SLAL: 111655298(inppl1) 111666355 111669582(inpp5d)
HCQ: 109516555 109525465(inppl1) 109532322(inpp5d)
BPEC: 110154735(inpp5d) 110158855 110174275(inppl1)
MALB: 109957514 109965768(inpp5d) 109970550(inppl1)
ELS: 105029544(inpp5d) 105029605(inppl1)
SFM: 108923188 108932224(inppl1) 108937425(inpp5d)
PKI: 111833861(inppl1) 111835066 111837595(inpp5d)
LCM: 102351582 102361839(INPPL1) 102365596(INPP5D)
CMK: 103179101(inppl1) 103185799(inpp5d)
RTP: 109914528(inppl1) 109914977(inpp5d) 109927453
APLC: 110981025
PCAN: 112555824
CRG: 105320686
MYI: 110463198
OBI: 106880499
LAK: 106158330
NVE: 5515466
EPA: 110241032
ADF: 107355719
AMIL: 114953961
PDAM: 113672378
SPIS: 111330862
DGT: 114523455
HMG: 100212864
AQU: 100641488
DFA: DFA_08125(Dd5P1)
 » show all
Reference
1  [PMID:8654924]
  Authors
Lioubin MN, Algate PA, Tsai S, Carlberg K, Aebersold A, Rohrschneider LR
  Title
p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.
  Journal
Genes Dev 10:1084-95 (1996)
DOI:10.1101/gad.10.9.1084
  Sequence
[mmu:16331]
Reference
2  [PMID:8643691]
  Authors
Damen JE, Liu L, Rosten P, Humphries RK, Jefferson AB, Majerus PW, Krystal G
  Title
The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.
  Journal
Proc Natl Acad Sci U S A 93:1689-93 (1996)
DOI:10.1073/pnas.93.4.1689
  Sequence
[mmu:16331]
Reference
3  [PMID:9341117]
  Authors
Giuriato S, Payrastre B, Drayer AL, Plantavid M, Woscholski R, Parker P, Erneux C, Chap H
  Title
Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets.
  Journal
J Biol Chem 272:26857-63 (1997)
DOI:10.1074/jbc.272.43.26857
  Sequence
[mmu:16331]
Reference
4  [PMID:8769125]
  Authors
Drayer AL, Pesesse X, De Smedt F, Woscholski R, Parker P, Erneux C
  Title
Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase.
  Journal
Biochem Biophys Res Commun 225:243-9 (1996)
DOI:10.1006/bbrc.1996.1161
  Sequence
[hsa:3635]
Reference
5  [PMID:9824312]
  Authors
Pesesse X, Moreau C, Drayer AL, Woscholski R, Parker P, Erneux C
  Title
The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity.
  Journal
FEBS Lett 437:301-3 (1998)
DOI:10.1016/S0014-5793(98)01255-1
  Sequence
[hsa:3636]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.86
IUBMB Enzyme Nomenclature: 3.1.3.86
ExPASy - ENZYME nomenclature database: 3.1.3.86
BRENDA, the Enzyme Database: 3.1.3.86

KEGG   REACTION: R09827
Entry
R09827                      Reaction                               

Name
1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase
Definition
Phosphatidylinositol-3,4,5-trisphosphate + H2O <=> 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate + Orthophosphate
Equation
Reaction class
RC00078  C05981_C11554
Enzyme
3.1.3.36        3.1.3.86
Pathway
rn00562  Inositol phosphate metabolism
rn01100  Metabolic pathways
Orthology
K01099  inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
K03084  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [EC:3.1.3.86]
K15909  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 [EC:3.1.3.86]
K20278  inositol polyphosphate 5-phosphatase INPP5E [EC:3.1.3.36]
K20279  synaptojanin [EC:3.1.3.36]
Other DBs
RHEA: 25531

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