KEGG   ORTHOLOGY: K03097
Entry
K03097                      KO                                     

Name
CSNK2A
Definition
casein kinase II subunit alpha [EC:2.7.11.1]
Pathway
ko03008  Ribosome biogenesis in eukaryotes
ko04064  NF-kappa B signaling pathway
ko04137  Mitophagy - animal
ko04139  Mitophagy - yeast
ko04310  Wnt signaling pathway
ko04520  Adherens junction
ko04712  Circadian rhythm - plant
ko05010  Alzheimer disease
ko05162  Measles
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09122 Translation
   03008 Ribosome biogenesis in eukaryotes
    K03097  CSNK2A; casein kinase II subunit alpha
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K03097  CSNK2A; casein kinase II subunit alpha
   04064 NF-kappa B signaling pathway
    K03097  CSNK2A; casein kinase II subunit alpha
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    K03097  CSNK2A; casein kinase II subunit alpha
   04139 Mitophagy - yeast
    K03097  CSNK2A; casein kinase II subunit alpha
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K03097  CSNK2A; casein kinase II subunit alpha
 09150 Organismal Systems
  09159 Environmental adaptation
   04712 Circadian rhythm - plant
    K03097  CSNK2A; casein kinase II subunit alpha
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K03097  CSNK2A; casein kinase II subunit alpha
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K03097  CSNK2A; casein kinase II subunit alpha
  09172 Infectious disease: viral
   05162 Measles
    K03097  CSNK2A; casein kinase II subunit alpha
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K03097  CSNK2A; casein kinase II subunit alpha
  09182 Protein families: genetic information processing
   03009 Ribosome biogenesis
    K03097  CSNK2A; casein kinase II subunit alpha
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K03097  CSNK2A; casein kinase II subunit alpha
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  CK2 family
   K03097  CSNK2A; casein kinase II subunit alpha
Ribosome biogenesis [BR:ko03009]
 Eukaryotic type
  90S particles
   Kinase
    K03097  CSNK2A; casein kinase II subunit alpha
Genes
HSA: 1457(CSNK2A1) 1459(CSNK2A2) 283106(CSNK2A3)
PTR: 454131(CSNK2A2) 458448(CSNK2A1)
PPS: 100968167(CSNK2A2) 100982778(CSNK2A1)
GGO: 101123844(CSNK2A2) 101148559(CSNK2A1)
PON: 100173187(CSNK2A1) 100450298(CSNK2A2)
NLE: 100588149(CSNK2A2) 100602220(CSNK2A1)
MCC: 712455(CSNK2A2) 714841(CSNK2A1)
MCF: 101865560(CSNK2A2) 102125825(CSNK2A1)
CSAB: 103216000(CSNK2A1) 103233082(CSNK2A2)
RRO: 104660810(CSNK2A1) 104664070(CSNK2A2)
RBB: 108533896(CSNK2A2) 108544543(CSNK2A1)
CJC: 100388528(CSNK2A2) 100414021(CSNK2A1)
SBQ: 101039128(CSNK2A1) 101048418(CSNK2A2)
MMU: 12995(Csnk2a1) 13000(Csnk2a2)
MCAL: 110290051(Csnk2a1) 110299969(Csnk2a2)
MPAH: 110317612(Csnk2a1) 110337286(Csnk2a2)
RNO: 116549(Csnk2a1) 307641(Csnk2a2)
MUN: 110551175(Csnk2a2) 110555818(Csnk2a1)
CGE: 100759365(Csnk2a1) 100763424(Csnk2a2)
NGI: 103735565(Csnk2a2) 103751629(Csnk2a1)
HGL: 101704753 101717615(Csnk2a2) 101724504(Csnk2a1)
CCAN: 109687013(Csnk2a2) 109687015(Csnk2a1)
OCU: 100301533(CSNK2A1) 100337973(CSNK2A2)
TUP: 102472736(CSNK2A1) 102488078(CSNK2A2)
CFA: 477185(CSNK2A1) 478108(CSNK2A2)
VVP: 112909900(CSNK2A1) 112929663(CSNK2A2)
AML: 100471788(CSNK2A1) 100479210(CSNK2A2)
UMR: 103673753(CSNK2A2) 103674361(CSNK2A1)
UAH: 113252303(CSNK2A2) 113258441(CSNK2A1)
ORO: 101364264(CSNK2A2) 101373397(CSNK2A1)
FCA: 101084186(CSNK2A1) 101093065(CSNK2A2)
PTG: 102963968(CSNK2A2) 102969391(CSNK2A1)
PPAD: 109270846(CSNK2A2) 109272621(CSNK2A1)
AJU: 106977015(CSNK2A2) 106986007(CSNK2A1)
BTA: 282419(CSNK2A1) 282420(CSNK2A2)
BOM: 102272104(CSNK2A2) 102281103(CSNK2A1)
BIU: 109567333(CSNK2A1) 109572558(CSNK2A2)
BBUB: 102405357(CSNK2A2) 102406114(CSNK2A1)
CHX: 102174419(CSNK2A2) 102175136(CSNK2A1)
OAS: 101121957(CSNK2A1) 101122459(CSNK2A2)
SSC: 100517435(CSNK2A1) 100737256(CSNK2A2)
CFR: 102507420(CSNK2A2) 102513219(CSNK2A1)
CDK: 105093799(CSNK2A2) 105100805(CSNK2A1)
BACU: 102997548(CSNK2A2) 103001174(CSNK2A1)
LVE: 103075126(CSNK2A2) 103085560(CSNK2A1)
OOR: 101284251(CSNK2A1) 101284883(CSNK2A2)
DLE: 111165308(CSNK2A2) 111184343(CSNK2A1)
PCAD: 102976104(CSNK2A1) 102992646(CSNK2A2)
ECB: 100063080(CSNK2A2) 100067965(CSNK2A1)
EPZ: 103556912(CSNK2A1) 103557853(CSNK2A2)
EAI: 106822212(CSNK2A2) 106833699(CSNK2A1)
MYB: 102247763(CSNK2A2) 102252710(CSNK2A1)
MYD: 102758153(CSNK2A1) 102770316(CSNK2A2)
MNA: 107527770(CSNK2A1) 107532190(CSNK2A2)
HAI: 109384437(CSNK2A1) 109394423(CSNK2A2)
DRO: 112296650(CSNK2A2) 112303577(CSNK2A1)
PALE: 102883511(CSNK2A1) 102893812(CSNK2A2)
RAY: 107502669(CSNK2A2) 107512905(CSNK2A1)
MJV: 108400430(CSNK2A1) 108406110(CSNK2A2)
LAV: 100653935(CSNK2A1) 100666770(CSNK2A2)
MDO: 100011177(CSNK2A1) 100025237(CSNK2A2)
SHR: 100917554(CSNK2A2) 100919559(CSNK2A1)
PCW: 110192507(CSNK2A2) 110211402(CSNK2A1)
OAA: 100074583(CSNK2A2) 100079695(CSNK2A1)
GGA: 415626(CSNK2A2) 432370(CSNK2A1)
MGP: 100539111(CSNK2A1) 100543840(CSNK2A2)
CJO: 107319011(CSNK2A2) 107323193(CSNK2A1)
NMEL: 110404356(CSNK2A2) 110408047(CSNK2A1)
APLA: 101794550(CSNK2A2) 101804286(CSNK2A1)
ACYG: 106033147(CSNK2A2) 106049375(CSNK2A1)
TGU: 100227081(CSNK2A2) 100231582(CSNK2A1)
LSR: 110468988(CSNK2A1) 110476334(CSNK2A2)
SCAN: 103816859(CSNK2A2) 103818676(CSNK2A1)
GFR: 102034730(CSNK2A2) 102036085(CSNK2A1)
FAB: 101815295(CSNK2A1) 101819895(CSNK2A2)
PHI: 102103552(CSNK2A1) 102106316(CSNK2A2)
PMAJ: 107209905(CSNK2A2) 107213350(CSNK2A1)
CCAE: 111938133(CSNK2A1) 111945611(CSNK2A2)
CCW: 104687702(CSNK2A1) 104691894(CSNK2A2)
ETL: 114062514(CSNK2A2) 114063006(CSNK2A1)
FPG: 101914165 101916240(CSNK2A2) 101924288(CSNK2A1)
FCH: 102045929 102047766(CSNK2A2) 102057085(CSNK2A1)
CLV: 102086938 102090503(CSNK2A2) 102098577(CSNK2A1)
EGZ: 104130018(CSNK2A1) 104130339(CSNK2A2)
NNI: 104011932(CSNK2A1) 104017457(CSNK2A2) 104023397
ACUN: 113484410(CSNK2A2) 113487710(CSNK2A1)
PADL: 103912576(CSNK2A2) 103922230
AAM: 106485795(CSNK2A2) 106487805 106497386(CSNK2A1)
ASN: 102368777(CSNK2A2) 102372323(CSNK2A1) 102373194
AMJ: 102564769(CSNK2A2) 102567583 106737049(CSNK2A1)
PSS: 102448017(CSNK2A2) 102449508(CSNK2A1) 102460464
CMY: 102930432(CSNK2A2) 102931790 102944082(CSNK2A1)
CPIC: 101931238(CSNK2A1) 101934017(CSNK2A2) 101940447
ACS: 100564077(csnk2a1) 100566597 100566912(csnk2a2)
PVT: 110081285(CSNK2A2) 110084827 110086037(CSNK2A1)
PMUA: 114599797(CSNK2A1) 114600143 114601844(CSNK2A2)
XLA: 108700964 108715461 399319(csnk2a1.S) 432180(csnk2a2.L)
XTR: 100498392(csnk2a1) 493442(csnk2a2)
NPR: 108786967(CSNK2A1)
DRE: 100535532(csnk2a4) 30488(csnk2a2a) 30502(csnk2a1) 415254(zgc:86598) 556379(csnk2a2b)
PRET: 103465502 103466228(csnk2a2) 103478532
CSEM: 103378870 103379463(csnk2a2) 103388495
SASA: 100195028(csk22) 100196311(csk21) 106560926(csnk2a2) 106565263 106573643 106583626 106587860(CSK22) 106587980 106588967(CSK21) 106605979(CSK22)
LCM: 102348027(CSNK2A1) 102348375(CSNK2A2) 102357461
CMK: 103183639 103185904(csnk2a2) 103188624(csnk2a1)
CIN: 445749(ck2a)
SPU: 580315
APLC: 110982179
SKO: 100303588(csnk2a1)
DME: Dmel_CG17520(CkIIalpha)
DER: 6544655
DSE: 6620126
DSI: Dsimw501_GD17656(Dsim_CkIIalpha)
DYA: Dyak_GE22657(Dyak_CkIIalpha)
DAN: 6493877
DSR: 110187675
DPE: 6592131
DMN: 108154925
DWI: 6647292
DAZ: 108621621
DNV: 108659795
DHE: 111598570
DVI: 6635251
MDE: 101896040
LCQ: 111678282
AAG: 5575837
AME: 409767
BIM: 100745536
BTER: 100650733
CCAL: 108629354
OBB: 114876580
SOC: 105204469
MPHA: 105839240
AEC: 105149257
ACEP: 105623791
PBAR: 105424116
VEM: 105568261
HST: 105182786
DQU: 106747739
CFO: 105256631
LHU: 105667387
PGC: 109853889
OBO: 105285395
PCF: 106788849
NVI: 100121624(Ckiialpha)
CSOL: 105361951
MDL: 103568907
BMOR: 692502(Ck2a)
BMAN: 114248670
PMAC: 106708972
PRAP: 111004043
HAW: 110375178
TNL: 113496312
API: 100160732
DNX: 107167750
AGS: 114132350
RMD: 113556364
BTAB: 109031642
ZNE: 110827390
FCD: 110852149
PVM: 113812677
TUT: 107363141
PTEP: 107441846
CEL: CELE_B0205.7(kin-3)
CBR: CBG12820(Cbr-kin-3)
BMY: Bm1_49830
TSP: Tsp_00251
PCAN: 112553328
MYI: 110453596
OBI: 106878394
LAK: 106170957
SHX: MS3_07757
EGL: EGR_04797
NVE: 5513344
EPA: 110253092
ADF: 107345725
AMIL: 114965095
PDAM: 113667521
SPIS: 111330969
DGT: 114532616
AQU: 100639610
ATH: AT2G23070 AT2G23080(CKA3) AT3G50000(CKA2) AT5G67380(CKA1)
LJA: Lj0g3v0186229.1(Lj0g3v0186229.1) Lj2g3v1963030.2(Lj2g3v1963030.2) Lj4g3v0768420.1(Lj4g3v0768420.1) Lj4g3v0771050.1(Lj4g3v0771050.1)
NTA: 107770013 107789145(NtCK2a1) 107789408(ck2A3) 107812932(CK2A) 107813210 107832227(NtCK2a3)
DOSA: Os03t0207300-01(Os03g0207300) Os03t0763000-01(Os03g0763000) Os07t0114400-01(Os07g0114400)
ATS: 109751515(LOC109751515) 109756860(LOC109756860) 109763006(LOC109763006) 109765969(LOC109765969)
APRO: F751_0837
SCE: YIL035C(CKA1) YOR061W(CKA2)
KMX: KLMA_20525(CKA1) KLMA_30262(CKA2)
NCS: NCAS_0A13320(NCAS0A13320) NCAS_0C05490(NCAS0C05490) NCAS_0G00490(NCAS0G00490)
NDI: NDAI_0A02720(NDAI0A02720) NDAI_0F00560(NDAI0F00560) NDAI_0H00610(NDAI0H00610)
TPF: TPHA_0B02780(TPHA0B02780) TPHA_0H01300(TPHA0H01300)
TBL: TBLA_0A09370(TBLA0A09370) TBLA_0E02460(TBLA0E02460)
TDL: TDEL_0B02610(TDEL0B02610) TDEL_0H02380(TDEL0H02380)
KAF: KAFR_0A02560(KAFR0A02560) KAFR_0K01310(KAFR0K01310)
PIC: PICST_69545(CKA1) PICST_86322(CKA2)
SLB: AWJ20_3024(CKA1) AWJ20_3138(CKA2)
NCR: NCU03124(cka)
NTE: NEUTE1DRAFT118888(NEUTE1DRAFT_118888)
MGR: MGG_03696
SSCK: SPSK_04364
MAW: MAC_07285
MAJ: MAA_00753
CMT: CCM_04103
MBE: MBM_03852
ANI: AN1485.2
ANG: ANI_1_1076144(An16g08010)
ABE: ARB_06432
TVE: TRV_01119
PTE: PTT_10550
SPO: SPAC23C11.11(cka1)
CNE: CNF02800
CNB: CNBF1910
TASA: A1Q1_04900
MRR: Moror_241
ABP: AGABI1DRAFT110117(AGABI1DRAFT_110117)
ABV: AGABI2DRAFT148114(AGABI2DRAFT_148114) AGABI2DRAFT189988(AGABI2DRAFT_189988)
MGL: MGL_3692
MRT: MRET_1655
DFA: DFA_07121(casK) DFA_09250
EHI: EHI_006800(53.t00023) EHI_038670(7.t00025) EHI_127290(129.t00005)
TAN: TA10630
TPV: TP04_0659
BBO: BBOV_III007790(17.m07683)
CPV: cgd6_620
SMIN: v1.2.013959.t1(symbB.v1.2.013959.t1) v1.2.029251.t1(symbB.v1.2.029251.t1)
 » show all
Reference
PMID:2752008
  Authors
Meisner H, Heller-Harrison R, Buxton J, Czech MP
  Title
Molecular cloning of the human casein kinase II alpha subunit.
  Journal
Biochemistry 28:4072-6 (1989)
DOI:10.1021/bi00435a066
  Sequence
[hsa:1457]
Reference
  Authors
Filhol O, Cochet C
  Title
Protein kinase CK2 in health and disease: Cellular functions of protein kinase CK2: a dynamic affair.
  Journal
Cell Mol Life Sci 66:1830-9 (2009)
DOI:10.1007/s00018-009-9151-1
  Sequence
[hsa:1457 1459]
Reference
  Authors
Berkey CD, Carlson M
  Title
A specific catalytic subunit isoform of protein kinase CK2 is required for phosphorylation of the repressor Nrg1 in Saccharomyces cerevisiae.
  Journal
Curr Genet 50:1-10 (2006)
DOI:10.1007/s00294-006-0070-5
  Sequence
Reference
  Authors
Kanki T, Kurihara Y, Jin X, Goda T, Ono Y, Aihara M, Hirota Y, Saigusa T, Aoki Y, Uchiumi T, Kang D
  Title
Casein kinase 2 is essential for mitophagy.
  Journal
EMBO Rep 14:788-94 (2013)
DOI:10.1038/embor.2013.114

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