KEGG   ORTHOLOGY: K03173
Entry
K03173                      KO                                     
Symbol
TRAF2
Name
TNF receptor-associated factor 2 [EC:2.3.2.27]
Pathway
map04010  MAPK signaling pathway
map04064  NF-kappa B signaling pathway
map04071  Sphingolipid signaling pathway
map04137  Mitophagy - animal
map04141  Protein processing in endoplasmic reticulum
map04210  Apoptosis
map04217  Necroptosis
map04380  Osteoclast differentiation
map04621  NOD-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04657  IL-17 signaling pathway
map04668  TNF signaling pathway
map04920  Adipocytokine signaling pathway
map04932  Non-alcoholic fatty liver disease
map05010  Alzheimer disease
map05014  Amyotrophic lateral sclerosis
map05016  Huntington disease
map05017  Spinocerebellar ataxia
map05022  Pathways of neurodegeneration - multiple diseases
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05135  Yersinia infection
map05160  Hepatitis C
map05163  Human cytomegalovirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05200  Pathways in cancer
map05203  Viral carcinogenesis
map05222  Small cell lung cancer
map05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K03173  TRAF2; TNF receptor-associated factor 2
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04064 NF-kappa B signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04668 TNF signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04071 Sphingolipid signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    K03173  TRAF2; TNF receptor-associated factor 2
  09143 Cell growth and death
   04210 Apoptosis
    K03173  TRAF2; TNF receptor-associated factor 2
   04217 Necroptosis
    K03173  TRAF2; TNF receptor-associated factor 2
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04622 RIG-I-like receptor signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04657 IL-17 signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K03173  TRAF2; TNF receptor-associated factor 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03173  TRAF2; TNF receptor-associated factor 2
   05203 Viral carcinogenesis
    K03173  TRAF2; TNF receptor-associated factor 2
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K03173  TRAF2; TNF receptor-associated factor 2
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05160 Hepatitis C
    K03173  TRAF2; TNF receptor-associated factor 2
   05168 Herpes simplex virus 1 infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05163 Human cytomegalovirus infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05169 Epstein-Barr virus infection
    K03173  TRAF2; TNF receptor-associated factor 2
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05132 Salmonella infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05131 Shigellosis
    K03173  TRAF2; TNF receptor-associated factor 2
   05135 Yersinia infection
    K03173  TRAF2; TNF receptor-associated factor 2
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K03173  TRAF2; TNF receptor-associated factor 2
   05014 Amyotrophic lateral sclerosis
    K03173  TRAF2; TNF receptor-associated factor 2
   05016 Huntington disease
    K03173  TRAF2; TNF receptor-associated factor 2
   05017 Spinocerebellar ataxia
    K03173  TRAF2; TNF receptor-associated factor 2
   05022 Pathways of neurodegeneration - multiple diseases
    K03173  TRAF2; TNF receptor-associated factor 2
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K03173  TRAF2; TNF receptor-associated factor 2
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K03173  TRAF2; TNF receptor-associated factor 2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K03173  TRAF2; TNF receptor-associated factor 2
   04121 Ubiquitin system
    K03173  TRAF2; TNF receptor-associated factor 2
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K03173  TRAF2; TNF receptor-associated factor 2
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    Stress granule specific factors
     K03173  TRAF2; TNF receptor-associated factor 2
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   TRAF proteins
    K03173  TRAF2; TNF receptor-associated factor 2
Genes
HSA: 7186(TRAF2)
PTR: 464876(TRAF2)
PPS: 100982095(TRAF2)
GGO: 101144745(TRAF2)
PON: 100458089(TRAF2)
PPYG: 129044456(TRAF2)
NLE: 100590721(TRAF2)
HMH: 116475877(TRAF2)
SSYN: 129478662(TRAF2)
MCC: 708391(TRAF2)
MCF: 101925175(TRAF2)
MTHB: 126936973
MNI: 105471953(TRAF2)
CSAB: 103239600(TRAF2)
CATY: 105580591(TRAF2)
PANU: 101017914(TRAF2)
TGE: 112608018(TRAF2)
MLEU: 105543266(TRAF2)
RRO: 104669650(TRAF2)
RBB: 108542901(TRAF2)
TFN: 117099135(TRAF2)
PTEH: 111553030(TRAF2)
CANG: 105522700(TRAF2)
CJC: 100404226(TRAF2)
SBQ: 101035434(TRAF2)
CIMI: 108287258(TRAF2)
ANAN: 105712159(TRAF2)
CSYR: 103252426(TRAF2)
MMUR: 105882282(TRAF2)
LCAT: 123645603(TRAF2)
PCOQ: 105818690(TRAF2)
OGA: 100966378(TRAF2)
MMU: 22030(Traf2)
MCAL: 110289986(Traf2)
MPAH: 110318405(Traf2)
RNO: 311786(Traf2)
MCOC: 116089826(Traf2)
ANU: 117710914(Traf2)
MUN: 110557003(Traf2)
CGE: 100762099(Traf2)
MAUA: 101823322(Traf2)
PROB: 127222603(Traf2)
PLEU: 114692795(Traf2)
MORG: 121463096(Traf2)
MFOT: 126509272
AAMP: 119818726(Traf2)
NGI: 103741188(Traf2)
HGL: 101705156(Traf2)
CPOC: 100733145(Traf2)
CCAN: 109699331(Traf2)
DORD: 105995582(Traf2)
DSP: 122099715(Traf2)
PLOP: 125351527(Traf2)
NCAR: 124964641
MMMA: 107159171(Traf2)
OPI: 101527835(TRAF2)
TUP: 102473925(C8G)
GVR: 103610047 103610988(TRAF2)
CFA: 480673(TRAF2)
CLUD: 112677465(TRAF2)
VVP: 112906881(TRAF2)
VLG: 121473786(TRAF2)
NPO: 129515072(TRAF2)
AML: 100474087(TRAF2)
UMR: 103675245(TRAF2)
UAH: 113248645(TRAF2)
UAR: 123796334(TRAF2)
ELK: 111145476 111146100
LLV: 125083298
MPUF: 101691230(TRAF2)
MNP: 132024227(TRAF2)
MLK: 131812685(TRAF2)
NVS: 122917083(TRAF2)
ORO: 101371938(TRAF2)
EJU: 114201735(TRAF2)
ZCA: 113934602(TRAF2)
MLX: 118017503(TRAF2)
NSU: 110581233(TRAF2)
LWW: 102736169 102738552
FCA: 101096363(TRAF2)
PYU: 121020261(TRAF2)
PCOO: 112860577(TRAF2)
PBG: 122474992(TRAF2)
PVIV: 125150056(TRAF2)
LRUF: 124522349
PTG: 102966802(TRAF2)
PPAD: 109258781(TRAF2)
PUC: 125923516
AJU: 106989490
HHV: 120226445(TRAF2)
BTA: 512355(TRAF2)
BOM: 102275265(TRAF2)
BIU: 109566626(TRAF2)
BBUB: 102395129(TRAF2)
BBIS: 104982944(TRAF2)
CHX: 102184255(TRAF2)
OAS: 101105235(TRAF2)
BTAX: 128055475(TRAF2)
ODA: 120852193(TRAF2)
CCAD: 122442423(TRAF2)
MBEZ: 129539173(TRAF2)
SSC: 100513840(TRAF2)
CFR: 102511649(TRAF2)
CBAI: 105068625(TRAF2)
CDK: 105106196(TRAF2)
VPC: 102537793(TRAF2)
BACU: 103013880(TRAF2)
BMUS: 118896967(TRAF2)
LVE: 103088738(TRAF2)
OOR: 101281303(TRAF2)
DLE: 111177009(TRAF2)
PCAD: 102996185(TRAF2)
PSIU: 116755387(TRAF2)
NASI: 112411269(TRAF2)
ECB: 100068006(TRAF2)
EPZ: 103567822(TRAF2)
EAI: 106845532(TRAF2)
MYB: 102263277(TRAF2)
MYD: 102772361(TRAF2)
MMYO: 118655263(TRAF2)
MDT: 132212630(TRAF2)
PKL: 118707045(TRAF2)
EFUS: 103295968(TRAF2)
MNA: 107536208(TRAF2)
DRO: 112306448(TRAF2)
SHON: 118980132(TRAF2)
AJM: 119036073(TRAF2)
PDIC: 114504307(TRAF2)
PHAS: 123823598(TRAF2)
MMF: 118629846(TRAF2)
PPAM: 129079528(TRAF2)
HAI: 109381672(TRAF2)
RFQ: 117031652(TRAF2)
PALE: 102889343(TRAF2)
PGIG: 120599784(TRAF2)
PVP: 105298613(TRAF2)
RAY: 107503081(TRAF2)
MJV: 108406827(TRAF2)
TOD: 119230651(TRAF2)
SARA: 101550002(TRAF2)
SETR: 126009254(TRAF2)
LAV: 100670400(TRAF2)
TMU: 101354911
ETF: 101643556(TRAF2)
DNM: 101412100(TRAF2)
MDO: 100017243(TRAF2)
GAS: 123237194(TRAF2)
SHR: 100934749(TRAF2)
AFZ: 127549124
PCW: 110205309(TRAF2)
TVP: 118844724(TRAF2)
OAA: 100681066 100681935(TRAF2)
GGA: 417287(TRAF2)
PCOC: 116234112(TRAF2)
MGP: 100545697(TRAF2)
CJO: 107321623(TRAF2)
TPAI: 128079775(TRAF2)
LMUT: 125702608(TRAF2)
NMEL: 110406784(TRAF2)
APLA: 101798982(TRAF2)
ACYG: 106037085(TRAF2)
CATA: 118260735(TRAF2)
AFUL: 116496858(TRAF2)
TGU: 100223400(TRAF2)
LSR: 110472193(TRAF2)
SCAN: 103819084(TRAF2)
PMOA: 120507355(TRAF2)
OTC: 121336904(TRAF2)
PRUF: 121357539(TRAF2)
GFR: 102033115(TRAF2)
FAB: 101807272(TRAF2)
OMA: 130260219(TRAF2)
PHI: 102106384(TRAF2)
PMAJ: 107212160(TRAF2)
CCAE: 111936895(TRAF2)
CCW: 104688205(TRAF2)
CBRC: 103614998(TRAF2)
ETL: 114064144(TRAF2)
ZAB: 102065720(TRAF2)
ZLE: 135454871(TRAF2)
ACHL: 103808775
SVG: 106855986(TRAF2)
MMEA: 130584583(TRAF2)
HRT: 120761764(TRAF2)
SATI: 136369649(TRAF2)
FPG: 101911961(TRAF2)
FCH: 102059920(TRAF2)
CCRI: 104160587(TRAF2)
NNT: 104402074(TRAF2)
SHAB: 115616900(TRAF2)
ACUN: 113486502(TRAF2)
TALA: 104362632(TRAF2)
ACHC: 115335375(TRAF2)
HALD: 104317841(TRAF2)
HLE: 104829986(TRAF2)
AGEN: 126052119
GCL: 127023695
CSTI: 104553367(TRAF2)
MNB: 103772482(TRAF2)
DPUB: 104300175(TRAF2)
AVIT: 104271225(TRAF2)
EGZ: 104124021(TRAF2)
NNI: 104018369(TRAF2)
PCRI: 104031731
PCAO: 104048946(TRAF2)
PADL: 103921138(TRAF2)
AFOR: 103908292(TRAF2)
FGA: 104083588(TRAF2)
GSTE: 104261965
CLV: 102095289(TRAF2)
MUI: 104546430(TRAF2)
PGUU: 104465418
PLET: 104628503(TRAF2)
EHS: 104513443(TRAF2)
CMAC: 104475837(TRAF2)
CUCA: 104059100(TRAF2)
TEO: 104383777(TRAF2)
BREG: 104643597(TRAF2)
OHA: 104338189(TRAF2)
ACAR: 104525088(TRAF2)
CPEA: 104397857(TRAF2)
CVF: 104291072(TRAF2)
RTD: 128917342(TRAF2)
AAM: 106494252(TRAF2)
AROW: 112969740(TRAF2)
NPD: 112956027(TRAF2)
TGT: 104573520(TRAF2)
DNE: 112986768(TRAF2)
SCAM: 104139746(TRAF2)
ASN: 102384689(TRAF2)
AMJ: 102564363(TRAF2)
CPOO: 109313783(TRAF2)
GGN: 109292831(TRAF2)
PSS: 102449635(TRAF2)
CMY: 102941067(TRAF2)
CCAY: 125623442(TRAF2)
DCC: 119842911 119844349(TRAF2)
CPIC: 101933518(TRAF2) 101946577
TST: 117867260(TRAF2)
CABI: 116832957(TRAF2)
MRV: 120386646(TRAF2) 120392446 120392485
ACS: 100561141(traf2) 100566904
ASAO: 132763641(TRAF2)
PVT: 110087462(TRAF2)
SUND: 121936587(TRAF2)
PBI: 103050015 103066991(TRAF2)
PMUR: 107296550 107302543(TRAF2)
CTIG: 120308629(TRAF2)
TSR: 106541963(TRAF2)
PGUT: 117667903 117676633(TRAF2)
APRI: 131186030(TRAF2) 131189602 131190217
PTEX: 113443864(TRAF2)
NSS: 113424253(TRAF2)
VKO: 123018020 123028318(TRAF2)
PMUA: 114583944(TRAF2) 114590009 114592029
PRAF: 128406935
ZVI: 118076102 118077655 118078499
HCG: 128338845(TRAF2) 128341897
GJA: 107115164(TRAF2) 107118266
STOW: 125427740 125441693(TRAF2)
EMC: 129341859(TRAF2)
XLA: 108698135(traf2.L) 431974(traf2.S)
XTR: 100494415(traf2)
NPR: 108787259(TRAF2)
RTEM: 120914048(TRAF2)
BBUF: 120977315(TRAF2)
BGAR: 122946429(TRAF2)
MUO: 115472619(TRAF2)
GSH: 117367797(TRAF2)
DRE: 100005446 557526(traf2b) 564295(traf2a)
SRX: 107709841 107715537 107715757 107725098 107730336(traf2) 107746475
SANH: 107654304 107681247 107684359(traf2) 107690679 107697985
SGH: 107557572 107560229 107567702 107587320 107591521 107595988
CCAR: 109063179 109066138 109088491 109103466
CAUA: 113049036 113049861 113068008 113073269 113073664 113074058 113083521(traf2)
CGIB: 127957102 127957622 127957860 127958691 127958692 127989236 128009188 128014856
PTET: 122345294(traf2b) 122345455 122345572(traf2a)
LROH: 127165041(traf2b) 127165370(traf2a) 127166047
OMC: 131540102(traf2b) 131540439(traf2a) 131540710
PPRM: 120469445(traf2a) 120471951(traf2b) 120490283
RKG: 130088204 130089827(traf2a)
MAMB: 125266535(traf2a) 125266915 125267992(traf2b)
CIDE: 127512151 127512173 127513416
CERY: 137033632(traf2a) 137033949(traf2b) 137033976
MASI: 127418979 127423392 127428703 127433991 127439016 127440016
TROS: 130546805(traf2a) 130550412(traf2b) 130564431
TDW: 130419012 130419428(traf2a) 130419591(traf2b)
MANU: 129439479 129440131(traf2a) 129441176(traf2b)
IPU: 108255825(traf2a) 108259928(traf2b)
IFU: 128598910(traf2a) 128603337(traf2b)
PHYP: 113531130(traf2) 113537061
SMEO: 124378726(traf2b) 124380617(traf2a)
TFD: 113641050(traf2b) 113653235(traf2a)
TVC: 132841351(traf2b) 132855231(traf2a)
TRN: 134303606(traf2b) 134335190(traf2a)
AMEX: 103028261(traf2b) 103036375(traf2a)
CMAO: 118814555(traf2b) 118827146(traf2a)
EEE: 113577947 113588078
CHAR: 105891184(traf2b) 105891672 105902465
TRU: 101064444 101075779 101076265(traf2)
TFS: 130517346 130517733(traf2b) 130526503
TNG: GSTEN00017168G001 GSTEN00020052G001 GSTEN00025207G001
LCO: 104925037 104930866 104939546
NCC: 104941091 104953558(traf2) 104966873
TBEN: 117472809 117476319 117476522(traf2b)
CGOB: 115013664 115016433(traf2) 115016852
PGEO: 117452000 117456137(traf2b) 117456685
GACU: 117534956 117538173(traf2b) 117561444
EMAC: 134868188(traf2b) 134873839
ELY: 117252396 117269357(traf2b) 117270142
EFO: 125890245(traf2a) 125905897 125906290(traf2b)
PLEP: 121944795 121959936 121959991(traf2b) 121966994
SLUC: 116034969(traf2b) 116050408 116062912
ECRA: 117945290 117958915(traf2b) 117959390
ESP: 116690145 116703984 116704577
PFLV: 114555721 114571020 114571300
GAT: 120830981(traf2a) 120831561 120831631(traf2b)
PPUG: 119225392(traf2a) 119226924 119226959(traf2b)
AFB: 129101424 129102855(traf2b)
CLUM: 117735999(traf2a) 117740351(traf2b) 117740886
PSWI: 130196697 130204860(traf2b) 130205745
MSAM: 119892126 119914658 119914703(traf2b)
SCHU: 122865199(traf2b) 122865536 122876306(traf2a)
CUD: 121509988(traf2a) 121525571 121525626(traf2b)
ALAT: 119019943(traf2a) 119029609(traf2b) 119030239
MZE: 101467121(traf2) 101472424 101473415
ONL: 100697308 100702092(traf2) 100708442
OAU: 116310474 116316361 116331708(traf2b)
OLA: 101155367 101159764(traf2) 101167626
OML: 112137707 112162880(traf2b) 112163300
CSAI: 133450814 133455207(traf2b)
XMA: 102217350 102227944 102233408
XCO: 114149230 114149726 114155101
XHE: 116723863 116724978 116730282
PRET: 103469572 103473320 103473816
PFOR: 103141905 103149802(traf2) 103154502
PLAI: 106947210 106950855(traf2) 106956159
PMEI: 106917048 106917430(traf2) 106930528
GAF: 122819276 122819462(traf2b) 122827742
PPRL: 129351631 129366457(traf2b) 129374289
CVG: 107092860 107096169(traf2) 107103870
CTUL: 119775800 119788282 119794722(traf2b)
GMU: 124872818 124872824(traf2b) 124878632
NFU: 107374323(traf2) 107374859 107395645
KMR: 108230862(traf2b) 108244062 108249884(traf2a)
ALIM: 106522826 106525877 106534871
NWH: 119413706 119424753 119424864(traf2b)
AOCE: 111568017 111576861 111580152 111584314
MCEP: 124996426(traf2b) 124997163 125012733
CSEM: 103390066 103390226 103397592
POV: 109625941 109626283 109633912
SSEN: 122758001(traf2b) 122758611 122769977
HHIP: 117767837(traf2a) 117771243(traf2b) 117771259
HSP: 118098034 118115649(traf2a) 118125819(traf2b)
PPLT: 128424762(traf2b) 128424856 128437829(traf2a)
SMAU: 118285230(traf2b) 118285297 118313432(traf2a)
LCF: 108874450(traf2b) 108878507(traf2a) 108895456
SDU: 111217845 111229789 111240026
SLAL: 111647918 111664872 111666015
XGL: 120805168(traf2a) 120806199(traf2b) 120806563
HCQ: 109510598 109517693 109520405
SSCV: 125979284 125979942 125994759
SBIA: 133490789 133499037 133515266(traf2b)
PEE: 133400426 133413579(traf2b) 133413736
PTAO: 133474596 133490230 133490304(traf2b)
BPEC: 110157567 110160661 110162182
MALB: 109959637 109960623(traf2) 109969783
BSPL: 114845605 114866528 114866591(traf2b)
SJO: 128364580 128380480(traf2b) 128380737
SASA: 106563020 106563303 106566762(traf2) 106567744 106585142
STRU: 115159584 115159699 115164249 115203961 115204052
OTW: 112220313 112220413(traf2b) 112230792 112230971 112248690(traf2a)
OMY: 100136087(traf2) 110509690 110523473 110523569(traf2b) 110525908(traf2a)
OGO: 124006998 124007347 124034131 124048979(traf2b) 124049064
ONE: 115101153 115111813 115121372 115122481 115147161
OKI: 109867953 109868524 109873949 109874390 109882539
OKE: 118379005 118385316 118385484 118387519(traf2b) 118393434
SALP: 111961627 111961730 111963931 111964003 111974936
SNH: 120021709 120021774 120025680 120025896 120055078
CCLU: 121541579 121541654 121582534(traf2b) 121582622 121585058
ELS: 105014393 105015035 105015142
SFM: 108922584 108929927 108938148
PKI: 111835361 111847460 111848593 111858668(traf2)
AANG: 118206207 118212933(traf2b) 118213211
LOC: 102693526(traf2) 102695888 107079892
PSPA: 121298723 121309606 121310834(traf2b)
ARUT: 117396690 117396934 117962289 117962309
PSEX: 120541999(traf2b) 120543219(traf2a)
LCM: 102355783(TRAF2) 102358173 102360751
CMK: 103183006 103184612
RTP: 109916783(traf2b) 109922055 109936083
CPLA: 122541173 122541513 122564593
HOC: 132826005(traf2b) 132832429 132832533
LERI: 129693903 129694202 129711946
PMRN: 116957399 116957458
LRJ: 133361160 133361163 133361243
BFO: 118407805 118407806 118407809 118409012 118409013 118409015 118409016 118409017 118409019 118409027
BBEL: 109462308 109466073 109466074 109466095 109466096 109466097 109466099 109471306
APLC: 110981046
ARUN: 117302925
SKO: 100366508 100367251 100368096 100368383 100369398 100370471 100370619 100373403 100373552 100373746 100373894 100374048 100374295 100378765 100379076 102804549
SLIU: 111354513
DSV: 119431129 119454989 119464233
RSAN: 119372506
RMP: 119163172
VDE: 111252987
VJA: 111271634
SDM: 118188644
PVUL: 126808639
PCAN: 112574945 112574946
BGT: 106056737
GAE: 121384699
HRF: 124143458
HRJ: 124270272
CRG: 105332371 105344264
CANU: 128155390
CVN: 111123728 111125920
OED: 125678257 125679191
MYI: 110464971
PMAX: 117315227
MMER: 123537020 123544852
RPHI: 132725349
DPOL: 127838476 127840069
MAEA: 128223841 128223861 128231500
OBI: 106879639
OSN: 115209082
LJP: 135481003
LAK: 106152529 106156836 106157982 106165819 106167630 106171106 106174963 106179037
LLON: 135501050
EPA: 110249597 110254489
ATEN: 116289125 116294857 116304828
ADF: 107329899 107346321 107346324 107350626
AMIL: 114974969 114976313
PDAM: 113673552 113686733
SPIS: 111336851 111339487 111339668 111339676 111342959 111345103 111345104
DGT: 114530087 114534740
XEN: 124448248 124448255 124448265 124448722 124448724 124456453
HMG: 100213781
HSY: 130623716 130656727
RES: 135693529 135696672
AQU: 100632088 100634364 100636556 100636957 100637085 100637463 100639254 100639381 100642094 109582571
 » show all
Reference
PMID:15383523
  Authors
He L, Grammer AC, Wu X, Lipsky PE
  Title
TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation.
  Journal
J Biol Chem 279:55855-65 (2004)
DOI:10.1074/jbc.M407284200
Reference
PMID:16299380
  Authors
Mauro C, Crescenzi E, De Mattia R, Pacifico F, Mellone S, Salzano S, de Luca C, D'Adamio L, Palumbo G, Formisano S, Vito P, Leonardi A
  Title
Central role of the scaffold protein tumor necrosis factor receptor-associated factor 2 in regulating endoplasmic reticulum stress-induced apoptosis.
  Journal
J Biol Chem 281:2631-8 (2006)
DOI:10.1074/jbc.M502181200
Reference
PMID:23453969
  Authors
Zhou AY, Shen RR, Kim E, Lock YJ, Xu M, Chen ZJ, Hahn WC
  Title
IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.
  Journal
Cell Rep 3:724-33 (2013)
DOI:10.1016/j.celrep.2013.01.031
Reference
PMID:7639698
  Authors
Song HY, Donner DB
  Title
Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor.
  Journal
Biochem J 309 ( Pt 3):825-9 (1995)
DOI:10.1042/bj3090825
  Sequence
[hsa:7186]

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (66)   
   KEGG PATHWAY (66)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1591)   
   KEGG GENES (827)   
   KEGG MGENES (386)   
   RefGene (375)   
   OC (3)   
Literature (4)   
   PubMed (4)   
All databases (1666)   

Download RDF
KEGG   ORTHOLOGY: K09849
Entry
K09849                      KO                                     
Symbol
TRAF5
Name
TNF receptor-associated factor 5
Pathway
map04064  NF-kappa B signaling pathway
map04217  Necroptosis
map04621  NOD-like receptor signaling pathway
map04657  IL-17 signaling pathway
map04668  TNF signaling pathway
map05131  Shigellosis
map05163  Human cytomegalovirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05200  Pathways in cancer
map05203  Viral carcinogenesis
map05222  Small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K09849  TRAF5; TNF receptor-associated factor 5
   04668 TNF signaling pathway
    K09849  TRAF5; TNF receptor-associated factor 5
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K09849  TRAF5; TNF receptor-associated factor 5
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K09849  TRAF5; TNF receptor-associated factor 5
   04657 IL-17 signaling pathway
    K09849  TRAF5; TNF receptor-associated factor 5
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K09849  TRAF5; TNF receptor-associated factor 5
   05203 Viral carcinogenesis
    K09849  TRAF5; TNF receptor-associated factor 5
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K09849  TRAF5; TNF receptor-associated factor 5
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K09849  TRAF5; TNF receptor-associated factor 5
   05168 Herpes simplex virus 1 infection
    K09849  TRAF5; TNF receptor-associated factor 5
   05163 Human cytomegalovirus infection
    K09849  TRAF5; TNF receptor-associated factor 5
   05169 Epstein-Barr virus infection
    K09849  TRAF5; TNF receptor-associated factor 5
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K09849  TRAF5; TNF receptor-associated factor 5
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K09849  TRAF5; TNF receptor-associated factor 5
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   TRAF proteins
    K09849  TRAF5; TNF receptor-associated factor 5
Genes
HSA: 7188(TRAF5)
PTR: 457711(TRAF5)
PPS: 100978119(TRAF5)
GGO: 101130440(TRAF5)
PON: 100453867(TRAF5)
PPYG: 129033607(TRAF5)
NLE: 100601779(TRAF5)
HMH: 116457552(TRAF5)
SSYN: 129458211(TRAF5)
MCC: 711879(TRAF5)
MCF: 102142772(TRAF5)
MTHB: 126948771
MNI: 105493576(TRAF5)
CSAB: 103230138(TRAF5)
CATY: 105577052(TRAF5)
PANU: 101024624(TRAF5)
TGE: 112610017(TRAF5)
MLEU: 105536404(TRAF5)
RRO: 104669508(TRAF5)
RBB: 108515877(TRAF5)
TFN: 117074021(TRAF5)
PTEH: 111531090(TRAF5)
CANG: 105509216(TRAF5)
CJC: 100388423(TRAF5)
SBQ: 101031994(TRAF5)
CIMI: 108302141(TRAF5)
ANAN: 105721902(TRAF5)
CSYR: 103260228(TRAF5)
MMUR: 105880516(TRAF5)
LCAT: 123627059(TRAF5)
PCOQ: 105805435(TRAF5)
OGA: 100957799(TRAF5)
MMU: 22033(Traf5)
MCAL: 110296886(Traf5)
MPAH: 110322137(Traf5)
RNO: 684173(Traf5)
MCOC: 116069008(Traf5)
ANU: 117716371(Traf5)
MUN: 110566223(Traf5)
CGE: 100760758(Traf5)
MAUA: 101838615(Traf5)
PROB: 127223954(Traf5)
PLEU: 114702410(Traf5)
MORG: 121435869(Traf5)
MFOT: 126505400
AAMP: 119827796(Traf5)
NGI: 103727039(Traf5)
HGL: 101704164(Traf5)
CPOC: 100721722(Traf5)
CCAN: 109692314(Traf5)
DORD: 105984909(Traf5)
DSP: 122109749(Traf5)
PLOP: 125359340(Traf5)
NCAR: 124961041
MMMA: 107140575(Traf5)
OCU: 100340005
OPI: 101524603(TRAF5)
TUP: 102478124(TRAF5)
GVR: 103599657(TRAF5)
CFA: 480019(TRAF5)
CLUD: 112648366(TRAF5)
VVP: 112907150(TRAF5)
VLG: 121492435(TRAF5)
NPO: 129505849(TRAF5)
AML: 100475872(TRAF5)
UMR: 103672476(TRAF5)
UAH: 113262665(TRAF5)
UAR: 123785826(TRAF5)
ELK: 111150675
LLV: 125085695
MPUF: 101671644(TRAF5)
MNP: 132025400(TRAF5)
MLK: 131815325(TRAF5)
NVS: 122918546(TRAF5)
ORO: 101373241(TRAF5)
EJU: 114225907(TRAF5)
ZCA: 113933278(TRAF5)
MLX: 118014299(TRAF5)
NSU: 110573917(TRAF5)
LWW: 102740611(TRAF5)
FCA: 101086032(TRAF5)
PYU: 121011741(TRAF5)
PCOO: 112857763(TRAF5)
PBG: 122476367(TRAF5)
PVIV: 125155205(TRAF5)
LRUF: 124510097
PTG: 102972430(TRAF5)
PPAD: 109254870(TRAF5)
PUC: 125925301
AJU: 106966776
HHV: 120230541(TRAF5)
BTA: 507234(TRAF5)
BOM: 102266053(TRAF5)
BIU: 109570606(TRAF5)
BBUB: 102413198(TRAF5)
BBIS: 104984231(TRAF5)
CHX: 102188243(TRAF5)
OAS: 101119408(TRAF5)
BTAX: 128061711(TRAF5)
ODA: 120880035(TRAF5)
CCAD: 122452144(TRAF5)
MBEZ: 129551247(TRAF5)
SSC: 396616(TRAF5)
CFR: 102507430(TRAF5)
CBAI: 105064517(TRAF5)
CDK: 105099319(TRAF5)
VPC: 102527879(TRAF5)
BACU: 103010499(TRAF5)
BMUS: 118879828(TRAF5)
LVE: 103075051(TRAF5)
OOR: 101280074(TRAF5)
DLE: 111184706(TRAF5)
PCAD: 102986959(TRAF5)
PSIU: 116738804(TRAF5)
NASI: 112403568(TRAF5)
ECB: 100055119(TRAF5)
EPZ: 103551972(TRAF5)
EAI: 106827146(TRAF5)
MYB: 102243439(TRAF5)
MYD: 102764568(TRAF5)
MMYO: 118672932(TRAF5)
MLF: 102436664(TRAF5)
MDT: 132221193(TRAF5)
PKL: 118721522(TRAF5)
EFUS: 103290060(TRAF5)
MNA: 107538857(TRAF5)
DRO: 112296542(TRAF5)
SHON: 119004242(TRAF5)
AJM: 119043073(TRAF5)
PDIC: 114511917(TRAF5)
PHAS: 123818527(TRAF5)
MMF: 118637497(TRAF5)
PPAM: 129062216(TRAF5)
HAI: 109379157(TRAF5)
RFQ: 117014270(TRAF5)
PALE: 102879730(TRAF5)
PGIG: 120617505(TRAF5)
PVP: 105295002(TRAF5)
RAY: 107521637(TRAF5)
MJV: 108385436(TRAF5)
TOD: 119234414(TRAF5)
LAV: 100663885(TRAF5)
TMU: 101358050
ETF: 101655200(TRAF5)
DNM: 101434084(TRAF5)
MDO: 100022268(TRAF5)
GAS: 123247914(TRAF5)
SHR: 100926831(TRAF5)
AFZ: 127562587
PCW: 110222706(TRAF5)
TVP: 118849057(TRAF5)
OAA: 100078367(TRAF5)
GGA: 374055(TRAF5)
PCOC: 116230246(TRAF5)
MGP: 100541595(TRAF5)
CJO: 107311111(TRAF5)
TPAI: 128082152(TRAF5)
LMUT: 125689316(TRAF5)
NMEL: 110396762(TRAF5)
APLA: 101797384(TRAF5)
ACYG: 106031523(TRAF5)
CATA: 118253382(TRAF5)
AFUL: 116488176(TRAF5)
TGU: 100219054(TRAF5)
LSR: 110479943(TRAF5)
SCAN: 103821528(TRAF5)
PMOA: 120496897(TRAF5)
OTC: 121340637(TRAF5)
PRUF: 121358814(TRAF5)
GFR: 102042050(TRAF5)
FAB: 101821791(TRAF5)
OMA: 130251003(TRAF5)
PHI: 102104462(TRAF5)
PMAJ: 107201904(TRAF5)
CCAE: 111926165(TRAF5)
CCW: 104685651(TRAF5)
CBRC: 103622703(TRAF5)
ETL: 114066923(TRAF5)
ZAB: 102073800(TRAF5)
ZLE: 135445894(TRAF5)
ACHL: 103799235(TRAF5)
SVG: 106853591(TRAF5)
MMEA: 130573002(TRAF5)
HRT: 120750959(TRAF5)
SATI: 136359483(TRAF5)
FPG: 101921400(TRAF5)
FCH: 102053015(TRAF5)
CCRI: 104154434
NNT: 104413671(TRAF5)
SHAB: 115614013(TRAF5)
ACUN: 113478255(TRAF5)
TALA: 104359233(TRAF5)
ACHC: 115349818(TRAF5)
HALD: 104317850(TRAF5)
HLE: 104837366(TRAF5)
AGEN: 126052719
GCL: 127014283
CSTI: 104549555
LDI: 104349268(TRAF5)
MNB: 103773581(TRAF5)
DPUB: 104297582(TRAF5)
AVIT: 104277670(TRAF5)
BRHI: 104491295(TRAF5)
EGZ: 104128738(TRAF5)
NNI: 104019677(TRAF5)
PCRI: 104024317(TRAF5)
PCAO: 104041089(TRAF5)
PADL: 103922096(TRAF5)
AFOR: 103899178(TRAF5)
FGA: 104077706(TRAF5)
GSTE: 104253599(TRAF5)
CLV: 102088528(TRAF5)
MUI: 104535949(TRAF5)
PGUU: 104458045(TRAF5)
PLET: 104618732(TRAF5)
EHS: 104511489(TRAF5)
CMAC: 104473441(TRAF5)
CUCA: 104058023(TRAF5)
TEO: 104376434(TRAF5)
BREG: 104639800(TRAF5)
OHA: 104327883(TRAF5)
ACAR: 104517421(TRAF5)
CPEA: 104391622(TRAF5)
CVF: 104289397(TRAF5)
RTD: 128906628(TRAF5)
AAM: 106490486(TRAF5)
AROW: 112969242(TRAF5)
NPD: 112955136(TRAF5)
TGT: 104568745(TRAF5)
DNE: 112989856(TRAF5)
SCAM: 104140281(TRAF5)
ASN: 102370403(TRAF5)
AMJ: 102564531(TRAF5)
CPOO: 109319695(TRAF5)
GGN: 109296824(TRAF5)
PSS: 102459505(TRAF5)
CMY: 102929887(TRAF5)
CCAY: 125633598(TRAF5)
DCC: 119852706(TRAF5)
CPIC: 101933745(TRAF5)
TST: 117874435(TRAF5)
CABI: 116814984(TRAF5)
MRV: 120402445(TRAF5)
ACS: 100555319(traf5)
ASAO: 132761451(TRAF5)
PVT: 110079501(TRAF5)
PBI: 103064879(TRAF5)
PMUR: 107288580(TRAF5)
CTIG: 120315390(TRAF5)
TSR: 106552805(TRAF5)
PGUT: 117671674(TRAF5)
APRI: 131189261(TRAF5)
PTEX: 113433296(TRAF5)
NSS: 113422230(TRAF5)
VKO: 123022938(TRAF5)
PMUA: 114594702(TRAF5)
PRAF: 128411169(TRAF5)
ZVI: 118083148(TRAF5)
HCG: 128351111(TRAF5)
GJA: 107124212(TRAF5)
STOW: 125426817(TRAF5)
EMC: 129331658(TRAF5)
XLA: 108716445(traf5.L)
XTR: 100491604(traf5)
NPR: 108784349(TRAF5)
RTEM: 120937931(TRAF5)
BBUF: 120999475(TRAF5)
BGAR: 122922944(TRAF5)
MUO: 115464250(TRAF5)
GSH: 117357464(TRAF5)
DRE: 563887(traf5)
SRX: 107732237 107753499
SANH: 107698239 107702253
SGH: 107550688 107588441
CCAR: 109047368 109060473
CAUA: 113039731 113065209
CGIB: 127943315 127987033
PTET: 122327270(traf5)
LROH: 127154163(traf5)
OMC: 131529626(traf5)
PPRM: 120468714(traf5)
RKG: 130101978(traf5)
MAMB: 125255103
CIDE: 127520774
CERY: 137027622(traf5)
MASI: 127438138 127438701
TROS: 130559868(traf5)
TDW: 130430049(traf5)
MANU: 129453396(traf5)
IPU: 108271110(traf5)
IFU: 128613353(traf5)
PHYP: 113534779
SMEO: 124391062(traf5)
TFD: 113657684(traf5)
TVC: 132853346(traf5)
TRN: 134331598(traf5)
AMEX: 103031120(traf5)
CMAO: 118819514(traf5)
EEE: 113569092
CHAR: 105907631(traf5)
LCO: 104936671
NCC: 104947442
TBEN: 117481733(traf5)
CGOB: 115027296
PGEO: 117449999(traf5)
GACU: 117553440(traf5)
EMAC: 134864101(traf5)
ELY: 117255650(traf5)
EFO: 125886130(traf5)
PLEP: 121942134(traf5)
SLUC: 116048148(traf5)
PFLV: 114546386
GAT: 120825302(traf5)
PPUG: 119217931(traf5)
AFB: 129095574(traf5)
CLUM: 117750140(traf5)
MSAM: 119899952
SCHU: 122873045(traf5)
CUD: 121508809(traf5)
ALAT: 119023819(traf5)
MZE: 101481248
ONL: 100697176
OAU: 116326583(traf5)
OLA: 101170323
OML: 112157264(traf5)
CSAI: 133447461(traf5)
KMR: 108249386(traf5)
AOCE: 111563258
MCEP: 125003547(traf5)
CSEM: 103383406
SSEN: 122762305(traf5)
SMAU: 118312887(traf5)
LCF: 108892171(traf5)
SDU: 111232930
SLAL: 111649752
XGL: 120799791(traf5)
MALB: 109971816
BSPL: 114860027(traf5)
SJO: 128378226(traf5)
SASA: 106564804 106585043(TRAF5)
STRU: 115178274 115208506
OTW: 112230449(traf5) 112265814
OMY: 110486074 110493771
OGO: 124002870 124002871 124016465
ONE: 115103970
OKI: 109875526 109890153
OKE: 118365071(traf5)
SALP: 111960656 112070308
SNH: 120022465(traf5) 120033051
CCLU: 121572365(traf5) 123490781
ELS: 105026840
SFM: 108933531(traf5)
PKI: 111853469(traf5)
AANG: 118221762(traf5)
LOC: 102698366(traf5)
PSPA: 121316160(traf5) 121317294
ARUT: 117402571 117411504
PSEX: 120516665(traf5)
LCM: 102355485(TRAF5)
CMK: 103178011
RTP: 109920924
CPLA: 122552801
HOC: 132819400
LERI: 129699700
BBEL: 109465918
OFU: 114366247
DSV: 119431967 119452895 119453015 119460671 119464227 119464231
RSAN: 119379109 119388951 119401552 119401571 119402313 119402483 119406443
RMP: 119159949 119161081 119163659 119163663 119163664 119163906 119163907 119164153 119164172 119164482 119164957 119176117 119185589 119187252
VDE: 111246021
VJA: 111266134
TUT: 107368829
DPOL: 127872910
EPA: 110251088
ATEN: 116289186 116293251 116300688 116307189
ADF: 107334241 107338670
AMIL: 114969979
DGT: 114530208 114530330
XEN: 124448782 124449680 124457012
HMG: 100211106 101238683 105843481 105845157
HSY: 130629611 130629765 130641213
AQU: 105312590 105312852 105315220 105315820 109581190 109582161
MTM: MYCTH_2311696
CTHR: CTHT_0001550
ELA: UCREL1_2077
PSCO: LY89DRAFT_713648
GLZ: GLAREA_01680
DDI: DDB_G0268444
DPP: DICPUDRAFT_76179
PTM: GSPATT00032957001
 » show all
Reference
PMID:21822258
  Authors
Sun D, Novotny M, Bulek K, Liu C, Li X, Hamilton T
  Title
Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF).
  Journal
Nat Immunol 12:853-60 (2011)
DOI:10.1038/ni.2081
Reference
PMID:9511754
  Authors
Mizushima S, Fujita M, Ishida T, Azuma S, Kato K, Hirai M, Otsuka M, Yamamoto T, Inoue J
  Title
Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5).
  Journal
Gene 207:135-40 (1998)
DOI:10.1016/S0378-1119(97)00616-1
  Sequence
[hsa:7188]

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