KEGG   ORTHOLOGY: K03173
Entry
K03173                      KO                                     
Symbol
TRAF2
Name
TNF receptor-associated factor 2 [EC:2.3.2.27]
Pathway
map04010  MAPK signaling pathway
map04064  NF-kappa B signaling pathway
map04071  Sphingolipid signaling pathway
map04137  Mitophagy - animal
map04141  Protein processing in endoplasmic reticulum
map04210  Apoptosis
map04217  Necroptosis
map04380  Osteoclast differentiation
map04621  NOD-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04657  IL-17 signaling pathway
map04668  TNF signaling pathway
map04920  Adipocytokine signaling pathway
map04932  Non-alcoholic fatty liver disease
map05010  Alzheimer disease
map05014  Amyotrophic lateral sclerosis
map05016  Huntington disease
map05017  Spinocerebellar ataxia
map05022  Pathways of neurodegeneration - multiple diseases
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05135  Yersinia infection
map05160  Hepatitis C
map05163  Human cytomegalovirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05200  Pathways in cancer
map05203  Viral carcinogenesis
map05222  Small cell lung cancer
map05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K03173  TRAF2; TNF receptor-associated factor 2
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04064 NF-kappa B signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04668 TNF signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04071 Sphingolipid signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    K03173  TRAF2; TNF receptor-associated factor 2
  09143 Cell growth and death
   04210 Apoptosis
    K03173  TRAF2; TNF receptor-associated factor 2
   04217 Necroptosis
    K03173  TRAF2; TNF receptor-associated factor 2
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04622 RIG-I-like receptor signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04657 IL-17 signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K03173  TRAF2; TNF receptor-associated factor 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03173  TRAF2; TNF receptor-associated factor 2
   05203 Viral carcinogenesis
    K03173  TRAF2; TNF receptor-associated factor 2
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K03173  TRAF2; TNF receptor-associated factor 2
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05160 Hepatitis C
    K03173  TRAF2; TNF receptor-associated factor 2
   05168 Herpes simplex virus 1 infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05163 Human cytomegalovirus infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05169 Epstein-Barr virus infection
    K03173  TRAF2; TNF receptor-associated factor 2
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05132 Salmonella infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05131 Shigellosis
    K03173  TRAF2; TNF receptor-associated factor 2
   05135 Yersinia infection
    K03173  TRAF2; TNF receptor-associated factor 2
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K03173  TRAF2; TNF receptor-associated factor 2
   05014 Amyotrophic lateral sclerosis
    K03173  TRAF2; TNF receptor-associated factor 2
   05016 Huntington disease
    K03173  TRAF2; TNF receptor-associated factor 2
   05017 Spinocerebellar ataxia
    K03173  TRAF2; TNF receptor-associated factor 2
   05022 Pathways of neurodegeneration - multiple diseases
    K03173  TRAF2; TNF receptor-associated factor 2
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K03173  TRAF2; TNF receptor-associated factor 2
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K03173  TRAF2; TNF receptor-associated factor 2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K03173  TRAF2; TNF receptor-associated factor 2
   04121 Ubiquitin system
    K03173  TRAF2; TNF receptor-associated factor 2
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K03173  TRAF2; TNF receptor-associated factor 2
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    Stress granule specific factors
     K03173  TRAF2; TNF receptor-associated factor 2
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   TRAF proteins
    K03173  TRAF2; TNF receptor-associated factor 2
Genes
HSA: 7186(TRAF2)
PTR: 464876(TRAF2)
PPS: 100982095(TRAF2)
GGO: 101144745(TRAF2)
PON: 100458089(TRAF2)
PPYG: 129044456(TRAF2)
NLE: 100590721(TRAF2)
HMH: 116475877(TRAF2)
SSYN: 129478662(TRAF2)
MCC: 708391(TRAF2)
MCF: 101925175(TRAF2)
MTHB: 126936973
MNI: 105471953(TRAF2)
CSAB: 103239600(TRAF2)
CATY: 105580591(TRAF2)
PANU: 101017914(TRAF2)
TGE: 112608018(TRAF2)
MLEU: 105543266(TRAF2)
RRO: 104669650(TRAF2)
RBB: 108542901(TRAF2)
TFN: 117099135(TRAF2)
PTEH: 111553030(TRAF2)
CANG: 105522700(TRAF2)
CJC: 100404226(TRAF2)
SBQ: 101035434(TRAF2)
CIMI: 108287258(TRAF2)
ANAN: 105712159(TRAF2)
CSYR: 103252426(TRAF2)
MMUR: 105882282(TRAF2)
LCAT: 123645603(TRAF2)
PCOQ: 105818690(TRAF2)
OGA: 100966378(TRAF2)
MMU: 22030(Traf2)
MCAL: 110289986(Traf2)
MPAH: 110318405(Traf2)
RNO: 311786(Traf2)
MCOC: 116089826(Traf2)
ANU: 117710914(Traf2)
MUN: 110557003(Traf2)
CGE: 100762099(Traf2)
MAUA: 101823322(Traf2)
PROB: 127222603(Traf2)
PLEU: 114692795(Traf2)
MORG: 121463096(Traf2)
MFOT: 126509272
AAMP: 119818726(Traf2)
NGI: 103741188(Traf2)
HGL: 101705156(Traf2)
CPOC: 100733145(Traf2)
CCAN: 109699331(Traf2)
DORD: 105995582(Traf2)
DSP: 122099715(Traf2)
PLOP: 125351527(Traf2)
NCAR: 124964641
MMMA: 107159171(Traf2)
OPI: 101527835(TRAF2)
TUP: 102473925(C8G)
GVR: 103610047 103610988(TRAF2)
CFA: 480673(TRAF2)
CLUD: 112677465(TRAF2)
VVP: 112906881(TRAF2)
VLG: 121473786(TRAF2)
NPO: 129515072(TRAF2)
AML: 100474087(TRAF2)
UMR: 103675245(TRAF2)
UAH: 113248645(TRAF2)
UAR: 123796334(TRAF2)
LLV: 125083298
MPUF: 101691230(TRAF2)
MNP: 132024227(TRAF2)
MLK: 131812685(TRAF2)
NVS: 122917083(TRAF2)
ORO: 101371938(TRAF2)
EJU: 114201735(TRAF2)
ZCA: 113934602(TRAF2)
MLX: 118017503(TRAF2)
NSU: 110581233(TRAF2)
FCA: 101096363(TRAF2)
PYU: 121020261(TRAF2)
PCOO: 112860577(TRAF2)
PBG: 122474992(TRAF2)
PVIV: 125150056(TRAF2)
LRUF: 124522349
PTG: 102966802(TRAF2)
PPAD: 109258781(TRAF2)
PUC: 125923516
AJU: 106989490
HHV: 120226445(TRAF2)
BTA: 512355(TRAF2)
BOM: 102275265(TRAF2)
BIU: 109566626(TRAF2)
BBUB: 102395129(TRAF2)
BBIS: 104982944(TRAF2)
CHX: 102184255(TRAF2)
OAS: 101105235(TRAF2)
BTAX: 128055475(TRAF2)
ODA: 120852193(TRAF2)
CCAD: 122442423(TRAF2)
MBEZ: 129539173(TRAF2)
SSC: 100513840(TRAF2)
CFR: 102511649(TRAF2)
CBAI: 105068625(TRAF2)
CDK: 105106196(TRAF2)
VPC: 102537793(TRAF2)
BACU: 103013880(TRAF2)
BMUS: 118896967(TRAF2)
LVE: 103088738(TRAF2)
OOR: 101281303(TRAF2)
DLE: 111177009(TRAF2)
PCAD: 102996185(TRAF2)
PSIU: 116755387(TRAF2)
NASI: 112411269(TRAF2)
ECB: 100068006(TRAF2)
EPZ: 103567822(TRAF2)
EAI: 106845532(TRAF2)
MYB: 102263277(TRAF2)
MYD: 102772361(TRAF2)
MMYO: 118655263(TRAF2)
MDT: 132212630(TRAF2)
PKL: 118707045(TRAF2)
EFUS: 103295968(TRAF2)
MNA: 107536208(TRAF2)
DRO: 112306448(TRAF2)
SHON: 118980132(TRAF2)
AJM: 119036073(TRAF2)
PDIC: 114504307(TRAF2)
PHAS: 123823598(TRAF2)
MMF: 118629846(TRAF2)
PPAM: 129079528(TRAF2)
HAI: 109381672(TRAF2)
RFQ: 117031652(TRAF2)
PALE: 102889343(TRAF2)
PGIG: 120599784(TRAF2)
PVP: 105298613(TRAF2)
RAY: 107503081(TRAF2)
MJV: 108406827(TRAF2)
TOD: 119230651(TRAF2)
SARA: 101550002(TRAF2)
SETR: 126009254(TRAF2)
LAV: 100670400(TRAF2)
TMU: 101354911
ETF: 101643556(TRAF2)
DNM: 101412100(TRAF2)
MDO: 100017243(TRAF2)
GAS: 123237194(TRAF2)
SHR: 100934749(TRAF2)
AFZ: 127549124
PCW: 110205309(TRAF2)
TVP: 118844724(TRAF2)
OAA: 100681066 100681935(TRAF2)
GGA: 417287(TRAF2)
PCOC: 116234112(TRAF2)
MGP: 100545697(TRAF2)
CJO: 107321623(TRAF2)
TPAI: 128079775(TRAF2)
LMUT: 125702608(TRAF2)
NMEL: 110406784(TRAF2)
APLA: 101798982(TRAF2)
ACYG: 106037085(TRAF2)
CATA: 118260735(TRAF2)
AFUL: 116496858(TRAF2)
TGU: 100223400(TRAF2)
LSR: 110472193(TRAF2)
SCAN: 103819084(TRAF2)
PMOA: 120507355(TRAF2)
OTC: 121336904(TRAF2)
PRUF: 121357539(TRAF2)
GFR: 102033115(TRAF2)
FAB: 101807272(TRAF2)
OMA: 130260219(TRAF2)
PHI: 102106384(TRAF2)
PMAJ: 107212160(TRAF2)
CCAE: 111936895(TRAF2)
CCW: 104688205(TRAF2)
CBRC: 103614998(TRAF2)
ETL: 114064144(TRAF2)
ZAB: 102065720(TRAF2)
ZLE: 135454871(TRAF2)
ACHL: 103808775
SVG: 106855986(TRAF2)
MMEA: 130584583(TRAF2)
HRT: 120761764(TRAF2)
SATI: 136369649(TRAF2)
FPG: 101911961(TRAF2)
FCH: 102059920(TRAF2)
CCRI: 104160587(TRAF2)
NNT: 104402074(TRAF2)
SHAB: 115616900(TRAF2)
ACUN: 113486502(TRAF2)
TALA: 104362632(TRAF2)
ACHC: 115335375(TRAF2)
HALD: 104317841(TRAF2)
HLE: 104829986(TRAF2)
AGEN: 126052119
GCL: 127023695
CSTI: 104553367(TRAF2)
MNB: 103772482(TRAF2)
DPUB: 104300175(TRAF2)
AVIT: 104271225(TRAF2)
EGZ: 104124021(TRAF2)
NNI: 104018369(TRAF2)
PCRI: 104031731
PCAO: 104048946(TRAF2)
PADL: 103921138(TRAF2)
AFOR: 103908292(TRAF2)
FGA: 104083588(TRAF2)
GSTE: 104261965
CLV: 102095289(TRAF2)
MUI: 104546430(TRAF2)
PGUU: 104465418
PLET: 104628503(TRAF2)
EHS: 104513443(TRAF2)
CMAC: 104475837(TRAF2)
CUCA: 104059100(TRAF2)
TEO: 104383777(TRAF2)
BREG: 104643597(TRAF2)
OHA: 104338189(TRAF2)
ACAR: 104525088(TRAF2)
CPEA: 104397857(TRAF2)
CVF: 104291072(TRAF2)
RTD: 128917342(TRAF2)
AAM: 106494252(TRAF2)
AROW: 112969740(TRAF2)
NPD: 112956027(TRAF2)
TGT: 104573520(TRAF2)
DNE: 112986768(TRAF2)
SCAM: 104139746(TRAF2)
ASN: 102384689(TRAF2)
AMJ: 102564363(TRAF2)
CPOO: 109313783(TRAF2)
GGN: 109292831(TRAF2)
PSS: 102449635(TRAF2)
CMY: 102941067(TRAF2)
CCAY: 125623442(TRAF2)
DCC: 119842911 119844349(TRAF2)
CPIC: 101933518(TRAF2) 101946577
TST: 117867260(TRAF2)
CABI: 116832957(TRAF2)
ACS: 100561141(traf2) 100566904
ASAO: 132763641(TRAF2)
PVT: 110087462(TRAF2)
SUND: 121936587(TRAF2)
PBI: 103050015 103066991(TRAF2)
PMUR: 107296550 107302543(TRAF2)
CTIG: 120308629(TRAF2)
TSR: 106541963(TRAF2)
PGUT: 117667903 117676633(TRAF2)
PTEX: 113443864(TRAF2)
NSS: 113424253(TRAF2)
VKO: 123018020 123028318(TRAF2)
PRAF: 128406935
HCG: 128338845(TRAF2) 128341897
GJA: 107115164(TRAF2) 107118266
STOW: 125427740 125441693(TRAF2)
EMC: 129341859(TRAF2)
XLA: 108698135(traf2.L) 431974(traf2.S)
XTR: 100494415(traf2)
NPR: 108787259(TRAF2)
RTEM: 120914048(TRAF2)
BBUF: 120977315(TRAF2)
BGAR: 122946429(TRAF2)
MUO: 115472619(TRAF2)
GSH: 117367797(TRAF2)
DRE: 100005446 557526(traf2b) 564295(traf2a)
PTET: 122345294(traf2b) 122345455 122345572(traf2a)
LROH: 127165041(traf2b) 127165370(traf2a) 127166047
OMC: 131540102(traf2b) 131540439(traf2a) 131540710
PPRM: 120469445(traf2a) 120471951(traf2b) 120490283
RKG: 130088204 130089827(traf2a)
MAMB: 125266535(traf2a) 125266915 125267992(traf2b)
CERY: 137033632(traf2a) 137033949(traf2b) 137033976
TROS: 130546805(traf2a) 130550412(traf2b) 130564431
TDW: 130419012 130419428(traf2a) 130419591(traf2b)
MANU: 129439479 129440131(traf2a) 129441176(traf2b)
IPU: 108255825(traf2a) 108259928(traf2b)
IFU: 128598910(traf2a) 128603337(traf2b)
PHYP: 113531130(traf2) 113537061
SMEO: 124378726(traf2b) 124380617(traf2a)
TFD: 113641050(traf2b) 113653235(traf2a)
TVC: 132841351(traf2b) 132855231(traf2a)
TRN: 134303606(traf2b) 134335190(traf2a)
AMEX: 103028261(traf2b) 103036375(traf2a)
CMAO: 118814555(traf2b) 118827146(traf2a)
EMAC: 134868188(traf2b) 134873839
EFO: 125890245(traf2a) 125905897 125906290(traf2b)
GAT: 120830981(traf2a) 120831561 120831631(traf2b)
PPUG: 119225392(traf2a) 119226924 119226959(traf2b)
AFB: 129101424 129102855(traf2b)
CLUM: 117735999(traf2a) 117740351(traf2b) 117740886
SCHU: 122865199(traf2b) 122865536 122876306(traf2a)
CUD: 121509988(traf2a) 121525571 121525626(traf2b)
ALAT: 119019943(traf2a) 119029609(traf2b) 119030239
CSAI: 133450814 133455207(traf2b)
KMR: 108230862(traf2b) 108244062 108249884(traf2a)
HHIP: 117767837(traf2a) 117771243(traf2b) 117771259
HSP: 118098034 118115649(traf2a) 118125819(traf2b)
PPLT: 128424762(traf2b) 128424856 128437829(traf2a)
SMAU: 118285230(traf2b) 118285297 118313432(traf2a)
LCF: 108874450(traf2b) 108878507(traf2a) 108895456
XGL: 120805168(traf2a) 120806199(traf2b) 120806563
OMY: 100136087(traf2) 110509690 110523473 110523569(traf2b) 110525908(traf2a)
PSEX: 120541999(traf2b) 120543219(traf2a)
APLC: 110981046
ARUN: 117302925
SLIU: 111354513
RSAN: 119372506
RMP: 119163172
VDE: 111252987
VJA: 111271634
SDM: 118188644
PVUL: 126808639
BGT: 106056737
GAE: 121384699
HRF: 124143458
HRJ: 124270272
CANU: 128155390
MYI: 110464971
PMAX: 117315227
RPHI: 132725349
OBI: 106879639
OSN: 115209082
LJP: 135481003
LLON: 135501050
HMG: 100213781
 » show all
Reference
  Authors
He L, Grammer AC, Wu X, Lipsky PE
  Title
TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation.
  Journal
J Biol Chem 279:55855-65 (2004)
DOI:10.1074/jbc.M407284200
Reference
  Authors
Mauro C, Crescenzi E, De Mattia R, Pacifico F, Mellone S, Salzano S, de Luca C, D'Adamio L, Palumbo G, Formisano S, Vito P, Leonardi A
  Title
Central role of the scaffold protein tumor necrosis factor receptor-associated factor 2 in regulating endoplasmic reticulum stress-induced apoptosis.
  Journal
J Biol Chem 281:2631-8 (2006)
DOI:10.1074/jbc.M502181200
Reference
  Authors
Zhou AY, Shen RR, Kim E, Lock YJ, Xu M, Chen ZJ, Hahn WC
  Title
IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.
  Journal
Cell Rep 3:724-33 (2013)
DOI:10.1016/j.celrep.2013.01.031
Reference
PMID:7639698
  Authors
Song HY, Donner DB
  Title
Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor.
  Journal
Biochem J 309 ( Pt 3):825-9 (1995)
DOI:10.1042/bj3090825
  Sequence
[hsa:7186]

KEGG   ORTHOLOGY: K09849
Entry
K09849                      KO                                     
Symbol
TRAF5
Name
TNF receptor-associated factor 5
Pathway
map04064  NF-kappa B signaling pathway
map04217  Necroptosis
map04621  NOD-like receptor signaling pathway
map04657  IL-17 signaling pathway
map04668  TNF signaling pathway
map05131  Shigellosis
map05163  Human cytomegalovirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05200  Pathways in cancer
map05203  Viral carcinogenesis
map05222  Small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K09849  TRAF5; TNF receptor-associated factor 5
   04668 TNF signaling pathway
    K09849  TRAF5; TNF receptor-associated factor 5
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K09849  TRAF5; TNF receptor-associated factor 5
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K09849  TRAF5; TNF receptor-associated factor 5
   04657 IL-17 signaling pathway
    K09849  TRAF5; TNF receptor-associated factor 5
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K09849  TRAF5; TNF receptor-associated factor 5
   05203 Viral carcinogenesis
    K09849  TRAF5; TNF receptor-associated factor 5
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K09849  TRAF5; TNF receptor-associated factor 5
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K09849  TRAF5; TNF receptor-associated factor 5
   05168 Herpes simplex virus 1 infection
    K09849  TRAF5; TNF receptor-associated factor 5
   05163 Human cytomegalovirus infection
    K09849  TRAF5; TNF receptor-associated factor 5
   05169 Epstein-Barr virus infection
    K09849  TRAF5; TNF receptor-associated factor 5
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K09849  TRAF5; TNF receptor-associated factor 5
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K09849  TRAF5; TNF receptor-associated factor 5
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   TRAF proteins
    K09849  TRAF5; TNF receptor-associated factor 5
Genes
HSA: 7188(TRAF5)
PTR: 457711(TRAF5)
PPS: 100978119(TRAF5)
GGO: 101130440(TRAF5)
PON: 100453867(TRAF5)
PPYG: 129033607(TRAF5)
NLE: 100601779(TRAF5)
HMH: 116457552(TRAF5)
SSYN: 129458211(TRAF5)
MCC: 711879(TRAF5)
MCF: 102142772(TRAF5)
MTHB: 126948771
MNI: 105493576(TRAF5)
CSAB: 103230138(TRAF5)
CATY: 105577052(TRAF5)
PANU: 101024624(TRAF5)
TGE: 112610017(TRAF5)
MLEU: 105536404(TRAF5)
RRO: 104669508(TRAF5)
RBB: 108515877(TRAF5)
TFN: 117074021(TRAF5)
PTEH: 111531090(TRAF5)
CANG: 105509216(TRAF5)
CJC: 100388423(TRAF5)
SBQ: 101031994(TRAF5)
CIMI: 108302141(TRAF5)
ANAN: 105721902(TRAF5)
CSYR: 103260228(TRAF5)
MMUR: 105880516(TRAF5)
LCAT: 123627059(TRAF5)
PCOQ: 105805435(TRAF5)
OGA: 100957799(TRAF5)
MMU: 22033(Traf5)
MCAL: 110296886(Traf5)
MPAH: 110322137(Traf5)
RNO: 684173(Traf5)
MCOC: 116069008(Traf5)
ANU: 117716371(Traf5)
MUN: 110566223(Traf5)
CGE: 100760758(Traf5)
MAUA: 101838615(Traf5)
PROB: 127223954(Traf5)
PLEU: 114702410(Traf5)
MORG: 121435869(Traf5)
MFOT: 126505400
AAMP: 119827796(Traf5)
NGI: 103727039(Traf5)
HGL: 101704164(Traf5)
CPOC: 100721722(Traf5)
CCAN: 109692314(Traf5)
DORD: 105984909(Traf5)
DSP: 122109749(Traf5)
PLOP: 125359340(Traf5)
NCAR: 124961041
MMMA: 107140575(Traf5)
OCU: 100340005
OPI: 101524603(TRAF5)
TUP: 102478124(TRAF5)
GVR: 103599657(TRAF5)
CFA: 480019(TRAF5)
CLUD: 112648366(TRAF5)
VVP: 112907150(TRAF5)
VLG: 121492435(TRAF5)
NPO: 129505849(TRAF5)
AML: 100475872(TRAF5)
UMR: 103672476(TRAF5)
UAH: 113262665(TRAF5)
UAR: 123785826(TRAF5)
ELK: 111150675
LLV: 125085695
MPUF: 101671644(TRAF5)
MNP: 132025400(TRAF5)
MLK: 131815325(TRAF5)
NVS: 122918546(TRAF5)
ORO: 101373241(TRAF5)
EJU: 114225907(TRAF5)
ZCA: 113933278(TRAF5)
MLX: 118014299(TRAF5)
NSU: 110573917(TRAF5)
LWW: 102740611(TRAF5)
FCA: 101086032(TRAF5)
PYU: 121011741(TRAF5)
PCOO: 112857763(TRAF5)
PBG: 122476367(TRAF5)
PVIV: 125155205(TRAF5)
LRUF: 124510097
PTG: 102972430(TRAF5)
PPAD: 109254870(TRAF5)
PUC: 125925301
AJU: 106966776
HHV: 120230541(TRAF5)
BTA: 507234(TRAF5)
BOM: 102266053(TRAF5)
BIU: 109570606(TRAF5)
BBUB: 102413198(TRAF5)
BBIS: 104984231(TRAF5)
CHX: 102188243(TRAF5)
OAS: 101119408(TRAF5)
BTAX: 128061711(TRAF5)
ODA: 120880035(TRAF5)
CCAD: 122452144(TRAF5)
MBEZ: 129551247(TRAF5)
SSC: 396616(TRAF5)
CFR: 102507430(TRAF5)
CBAI: 105064517(TRAF5)
CDK: 105099319(TRAF5)
VPC: 102527879(TRAF5)
BACU: 103010499(TRAF5)
BMUS: 118879828(TRAF5)
LVE: 103075051(TRAF5)
OOR: 101280074(TRAF5)
DLE: 111184706(TRAF5)
PCAD: 102986959(TRAF5)
PSIU: 116738804(TRAF5)
NASI: 112403568(TRAF5)
ECB: 100055119(TRAF5)
EPZ: 103551972(TRAF5)
EAI: 106827146(TRAF5)
MYB: 102243439(TRAF5)
MYD: 102764568(TRAF5)
MMYO: 118672932(TRAF5)
MLF: 102436664(TRAF5)
MDT: 132221193(TRAF5)
PKL: 118721522(TRAF5)
EFUS: 103290060(TRAF5)
MNA: 107538857(TRAF5)
DRO: 112296542(TRAF5)
SHON: 119004242(TRAF5)
AJM: 119043073(TRAF5)
PDIC: 114511917(TRAF5)
PHAS: 123818527(TRAF5)
MMF: 118637497(TRAF5)
PPAM: 129062216(TRAF5)
HAI: 109379157(TRAF5)
RFQ: 117014270(TRAF5)
PALE: 102879730(TRAF5)
PGIG: 120617505(TRAF5)
PVP: 105295002(TRAF5)
RAY: 107521637(TRAF5)
MJV: 108385436(TRAF5)
TOD: 119234414(TRAF5)
LAV: 100663885(TRAF5)
TMU: 101358050
ETF: 101655200(TRAF5)
DNM: 101434084(TRAF5)
MDO: 100022268(TRAF5)
GAS: 123247914(TRAF5)
SHR: 100926831(TRAF5)
AFZ: 127562587
PCW: 110222706(TRAF5)
TVP: 118849057(TRAF5)
OAA: 100078367(TRAF5)
GGA: 374055(TRAF5)
PCOC: 116230246(TRAF5)
MGP: 100541595(TRAF5)
CJO: 107311111(TRAF5)
TPAI: 128082152(TRAF5)
LMUT: 125689316(TRAF5)
NMEL: 110396762(TRAF5)
APLA: 101797384(TRAF5)
ACYG: 106031523(TRAF5)
CATA: 118253382(TRAF5)
AFUL: 116488176(TRAF5)
TGU: 100219054(TRAF5)
LSR: 110479943(TRAF5)
SCAN: 103821528(TRAF5)
PMOA: 120496897(TRAF5)
OTC: 121340637(TRAF5)
PRUF: 121358814(TRAF5)
GFR: 102042050(TRAF5)
FAB: 101821791(TRAF5)
OMA: 130251003(TRAF5)
PHI: 102104462(TRAF5)
PMAJ: 107201904(TRAF5)
CCAE: 111926165(TRAF5)
CCW: 104685651(TRAF5)
CBRC: 103622703(TRAF5)
ETL: 114066923(TRAF5)
ZAB: 102073800(TRAF5)
ZLE: 135445894(TRAF5)
ACHL: 103799235(TRAF5)
SVG: 106853591(TRAF5)
MMEA: 130573002(TRAF5)
HRT: 120750959(TRAF5)
SATI: 136359483(TRAF5)
FPG: 101921400(TRAF5)
FCH: 102053015(TRAF5)
CCRI: 104154434
NNT: 104413671(TRAF5)
SHAB: 115614013(TRAF5)
ACUN: 113478255(TRAF5)
TALA: 104359233(TRAF5)
ACHC: 115349818(TRAF5)
HALD: 104317850(TRAF5)
HLE: 104837366(TRAF5)
AGEN: 126052719
GCL: 127014283
CSTI: 104549555
LDI: 104349268(TRAF5)
MNB: 103773581(TRAF5)
DPUB: 104297582(TRAF5)
AVIT: 104277670(TRAF5)
BRHI: 104491295(TRAF5)
EGZ: 104128738(TRAF5)
NNI: 104019677(TRAF5)
PCRI: 104024317(TRAF5)
PCAO: 104041089(TRAF5)
PADL: 103922096(TRAF5)
AFOR: 103899178(TRAF5)
FGA: 104077706(TRAF5)
GSTE: 104253599(TRAF5)
CLV: 102088528(TRAF5)
MUI: 104535949(TRAF5)
PGUU: 104458045(TRAF5)
PLET: 104618732(TRAF5)
EHS: 104511489(TRAF5)
CMAC: 104473441(TRAF5)
CUCA: 104058023(TRAF5)
TEO: 104376434(TRAF5)
BREG: 104639800(TRAF5)
OHA: 104327883(TRAF5)
ACAR: 104517421(TRAF5)
CPEA: 104391622(TRAF5)
CVF: 104289397(TRAF5)
RTD: 128906628(TRAF5)
AAM: 106490486(TRAF5)
AROW: 112969242(TRAF5)
NPD: 112955136(TRAF5)
TGT: 104568745(TRAF5)
DNE: 112989856(TRAF5)
SCAM: 104140281(TRAF5)
ASN: 102370403(TRAF5)
AMJ: 102564531(TRAF5)
CPOO: 109319695(TRAF5)
GGN: 109296824(TRAF5)
PSS: 102459505(TRAF5)
CMY: 102929887(TRAF5)
CCAY: 125633598(TRAF5)
DCC: 119852706(TRAF5)
CPIC: 101933745(TRAF5)
TST: 117874435(TRAF5)
CABI: 116814984(TRAF5)
MRV: 120402445(TRAF5)
ACS: 100555319(traf5)
ASAO: 132761451(TRAF5)
PVT: 110079501(TRAF5)
PBI: 103064879(TRAF5)
PMUR: 107288580(TRAF5)
CTIG: 120315390(TRAF5)
TSR: 106552805(TRAF5)
PGUT: 117671674(TRAF5)
APRI: 131189261(TRAF5)
PTEX: 113433296(TRAF5)
NSS: 113422230(TRAF5)
VKO: 123022938(TRAF5)
PMUA: 114594702(TRAF5)
PRAF: 128411169(TRAF5)
ZVI: 118083148(TRAF5)
HCG: 128351111(TRAF5)
GJA: 107124212(TRAF5)
STOW: 125426817(TRAF5)
EMC: 129331658(TRAF5)
XLA: 108716445(traf5.L)
XTR: 100491604(traf5)
NPR: 108784349(TRAF5)
RTEM: 120937931(TRAF5)
BBUF: 120999475(TRAF5)
BGAR: 122922944(TRAF5)
MUO: 115464250(TRAF5)
GSH: 117357464(TRAF5)
DRE: 563887(traf5)
PTET: 122327270(traf5)
LROH: 127154163(traf5)
OMC: 131529626(traf5)
PPRM: 120468714(traf5)
RKG: 130101978(traf5)
MAMB: 125255103
CIDE: 127520774
CERY: 137027622(traf5)
TROS: 130559868(traf5)
TDW: 130430049(traf5)
MANU: 129453396(traf5)
IPU: 108271110(traf5)
IFU: 128613353(traf5)
PHYP: 113534779
SMEO: 124391062(traf5)
TFD: 113657684(traf5)
TVC: 132853346(traf5)
TRN: 134331598(traf5)
AMEX: 103031120(traf5)
CMAO: 118819514(traf5)
EEE: 113569092
CHAR: 105907631(traf5)
LCO: 104936671
NCC: 104947442
TBEN: 117481733(traf5)
CGOB: 115027296
PGEO: 117449999(traf5)
GACU: 117553440(traf5)
EMAC: 134864101(traf5)
ELY: 117255650(traf5)
EFO: 125886130(traf5)
PLEP: 121942134(traf5)
SLUC: 116048148(traf5)
PFLV: 114546386
GAT: 120825302(traf5)
PPUG: 119217931(traf5)
AFB: 129095574(traf5)
CLUM: 117750140(traf5)
MSAM: 119899952
SCHU: 122873045(traf5)
CUD: 121508809(traf5)
ALAT: 119023819(traf5)
MZE: 101481248
ONL: 100697176
OAU: 116326583(traf5)
OLA: 101170323
OML: 112157264(traf5)
CSAI: 133447461(traf5)
KMR: 108249386(traf5)
AOCE: 111563258
MCEP: 125003547(traf5)
CSEM: 103383406
SSEN: 122762305(traf5)
SMAU: 118312887(traf5)
LCF: 108892171(traf5)
SDU: 111232930
SLAL: 111649752
XGL: 120799791(traf5)
MALB: 109971816
BSPL: 114860027(traf5)
SJO: 128378226(traf5)
SASA: 106564804 106585043(TRAF5)
OTW: 112230449(traf5) 112265814
ONE: 115103970
OKE: 118365071(traf5)
SNH: 120022465(traf5) 120033051
CCLU: 121572365(traf5) 123490781
ELS: 105026840
SFM: 108933531(traf5)
PKI: 111853469(traf5)
AANG: 118221762(traf5)
LOC: 102698366(traf5)
PSPA: 121316160(traf5) 121317294
PSEX: 120516665(traf5)
LCM: 102355485(TRAF5)
CMK: 103178011
RTP: 109920924
CPLA: 122552801
HOC: 132819400
LERI: 129699700
BBEL: 109465918
OFU: 114366247
VDE: 111246021
VJA: 111266134
TUT: 107368829
DPOL: 127872910
EPA: 110251088
AMIL: 114969979
 » show all
Reference
  Authors
Sun D, Novotny M, Bulek K, Liu C, Li X, Hamilton T
  Title
Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF).
  Journal
Nat Immunol 12:853-60 (2011)
DOI:10.1038/ni.2081
Reference
PMID:9511754
  Authors
Mizushima S, Fujita M, Ishida T, Azuma S, Kato K, Hirai M, Otsuka M, Yamamoto T, Inoue J
  Title
Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5).
  Journal
Gene 207:135-40 (1998)
DOI:10.1016/S0378-1119(97)00616-1
  Sequence
[hsa:7188]

KEGG   ORTHOLOGY: K03175
Entry
K03175                      KO                                     
Symbol
TRAF6
Name
TNF receptor-associated factor 6 [EC:2.3.2.27]
Pathway
map04010  MAPK signaling pathway
map04013  MAPK signaling pathway - fly
map04064  NF-kappa B signaling pathway
map04120  Ubiquitin mediated proteolysis
map04140  Autophagy - animal
map04144  Endocytosis
map04214  Apoptosis - fly
map04380  Osteoclast differentiation
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04657  IL-17 signaling pathway
map04722  Neurotrophin signaling pathway
map04936  Alcoholic liver disease
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05133  Pertussis
map05135  Yersinia infection
map05140  Leishmaniasis
map05142  Chagas disease
map05145  Toxoplasmosis
map05152  Tuberculosis
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05222  Small cell lung cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
map05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K03175  TRAF6; TNF receptor-associated factor 6
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
   04013 MAPK signaling pathway - fly
    K03175  TRAF6; TNF receptor-associated factor 6
   04064 NF-kappa B signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K03175  TRAF6; TNF receptor-associated factor 6
   04140 Autophagy - animal
    K03175  TRAF6; TNF receptor-associated factor 6
  09143 Cell growth and death
   04214 Apoptosis - fly
    K03175  TRAF6; TNF receptor-associated factor 6
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
   04621 NOD-like receptor signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
   04622 RIG-I-like receptor signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
   04657 IL-17 signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K03175  TRAF6; TNF receptor-associated factor 6
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03175  TRAF6; TNF receptor-associated factor 6
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K03175  TRAF6; TNF receptor-associated factor 6
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K03175  TRAF6; TNF receptor-associated factor 6
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K03175  TRAF6; TNF receptor-associated factor 6
   05161 Hepatitis B
    K03175  TRAF6; TNF receptor-associated factor 6
   05160 Hepatitis C
    K03175  TRAF6; TNF receptor-associated factor 6
   05171 Coronavirus disease - COVID-19
    K03175  TRAF6; TNF receptor-associated factor 6
   05162 Measles
    K03175  TRAF6; TNF receptor-associated factor 6
   05168 Herpes simplex virus 1 infection
    K03175  TRAF6; TNF receptor-associated factor 6
   05169 Epstein-Barr virus infection
    K03175  TRAF6; TNF receptor-associated factor 6
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K03175  TRAF6; TNF receptor-associated factor 6
   05132 Salmonella infection
    K03175  TRAF6; TNF receptor-associated factor 6
   05131 Shigellosis
    K03175  TRAF6; TNF receptor-associated factor 6
   05135 Yersinia infection
    K03175  TRAF6; TNF receptor-associated factor 6
   05133 Pertussis
    K03175  TRAF6; TNF receptor-associated factor 6
   05152 Tuberculosis
    K03175  TRAF6; TNF receptor-associated factor 6
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K03175  TRAF6; TNF receptor-associated factor 6
   05140 Leishmaniasis
    K03175  TRAF6; TNF receptor-associated factor 6
   05142 Chagas disease
    K03175  TRAF6; TNF receptor-associated factor 6
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K03175  TRAF6; TNF receptor-associated factor 6
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K03175  TRAF6; TNF receptor-associated factor 6
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K03175  TRAF6; TNF receptor-associated factor 6
   04121 Ubiquitin system
    K03175  TRAF6; TNF receptor-associated factor 6
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K03175  TRAF6; TNF receptor-associated factor 6
Membrane trafficking [BR:ko04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    K03175  TRAF6; TNF receptor-associated factor 6
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   TRAF proteins
    K03175  TRAF6; TNF receptor-associated factor 6
Genes
HSA: 7189(TRAF6)
PTR: 451702(TRAF6)
PPS: 100983960(TRAF6)
GGO: 101152087(TRAF6)
PON: 100449432(TRAF6)
PPYG: 129007610(TRAF6)
NLE: 100595327(TRAF6)
HMH: 116476347(TRAF6)
SSYN: 129484229(TRAF6)
MCC: 716907(TRAF6)
MCF: 102128596(TRAF6)
MTHB: 126936615
MNI: 105471571(TRAF6)
CSAB: 103237554(TRAF6)
CATY: 105586809(TRAF6)
PANU: 101002649(TRAF6)
TGE: 112607412(TRAF6)
MLEU: 105534673(TRAF6)
RRO: 104658364(TRAF6)
RBB: 108535559(TRAF6)
TFN: 117080232(TRAF6)
PTEH: 111521878(TRAF6)
CANG: 105510802(TRAF6)
CJC: 100395364(TRAF6)
SBQ: 101033308(TRAF6)
CIMI: 108305750(TRAF6)
ANAN: 105717285(TRAF6)
CSYR: 103263671(TRAF6)
MMUR: 105856828(TRAF6)
LCAT: 123642600(TRAF6)
PCOQ: 105814571(TRAF6)
OGA: 100945817(TRAF6)
MMU: 22034(Traf6)
MCAL: 110290132(Traf6)
MPAH: 110318382(Traf6)
RNO: 311245(Traf6)
MCOC: 116090551(Traf6)
ANU: 117703656(Traf6)
MUN: 110557497(Traf6)
CGE: 100753700(Traf6)
MAUA: 101830563(Traf6)
PROB: 127222196(Traf6)
PLEU: 114710754(Traf6)
MORG: 121440550 121465651(Traf6)
MFOT: 126504640
AAMP: 119814858(Traf6)
NGI: 103749513(Traf6)
HGL: 101697126(Traf6)
CPOC: 100724447(Traf6)
CCAN: 109693564(Traf6)
DORD: 105988129(Traf6)
DSP: 122117775(Traf6)
PLOP: 125361532(Traf6)
NCAR: 124959952
MMMA: 107135761(Traf6)
OCU: 100343190
OPI: 101518298(TRAF6)
TUP: 102482652(TRAF6)
GVR: 103601167(TRAF6)
CFA: 100688110(TRAF6)
CLUD: 112663495(TRAF6)
VVP: 112930471(TRAF6)
VLG: 121471306(TRAF6)
NPO: 129494142(TRAF6)
AML: 100483216(TRAF6)
UMR: 103659308(TRAF6)
UAH: 113265029(TRAF6)
UAR: 123799411(TRAF6)
ELK: 111150027
LLV: 125078866
MPUF: 101691506(TRAF6)
MNP: 132021320(TRAF6)
MLK: 131811444(TRAF6)
NVS: 122912847(TRAF6)
ORO: 101362953(TRAF6)
EJU: 114215395(TRAF6)
ZCA: 113913973(TRAF6)
MLX: 118015773(TRAF6)
NSU: 110576276(TRAF6)
LWW: 102728739(TRAF6)
FCA: 101099750(TRAF6)
PYU: 121043535(TRAF6)
PCOO: 112865434(TRAF6)
PBG: 122483712(TRAF6)
PVIV: 125177111(TRAF6)
LRUF: 124505383
PTG: 102960157(TRAF6)
PPAD: 109279193(TRAF6)
PUC: 125934537
AJU: 106976941
HHV: 120232555(TRAF6)
BTA: 539124(TRAF6) 782032
BOM: 102285891(TRAF6)
BIU: 109565970
BBUB: 102399580(TRAF6)
BBIS: 104982477(TRAF6)
CHX: 102172830(TRAF6)
OAS: 101107132(TRAF6)
BTAX: 128060227(TRAF6)
ODA: 120876881(TRAF6)
CCAD: 122449806(TRAF6)
MBEZ: 129554762(TRAF6)
SSC: 396629(TRAF6)
CFR: 102520181(TRAF6)
CBAI: 105076500(TRAF6)
CDK: 105106823(TRAF6)
VPC: 102540938(TRAF6)
BACU: 103018592(TRAF6)
BMUS: 118899213(TRAF6)
LVE: 103088795
OOR: 101277553(TRAF6)
DLE: 111179772(TRAF6)
PCAD: 102993207(TRAF6)
PSIU: 116757663(TRAF6)
NASI: 112404544(TRAF6)
ECB: 100052296(TRAF6)
EPZ: 103560236(TRAF6)
EAI: 106837480(TRAF6)
MYB: 102250946(TRAF6)
MYD: 102765934(TRAF6)
MMYO: 118665127(TRAF6)
MLF: 102436804(TRAF6)
MDT: 132241254(TRAF6)
PKL: 118712509(TRAF6)
EFUS: 103290874(TRAF6)
MNA: 107531990(TRAF6)
DRO: 112303407(TRAF6)
SHON: 118983180(TRAF6)
AJM: 119036455(TRAF6)
PDIC: 114500758(TRAF6)
PHAS: 123809979(TRAF6)
MMF: 118628151(TRAF6)
PPAM: 129080456(TRAF6)
HAI: 109381153(TRAF6)
RFQ: 117030261(TRAF6)
PALE: 102886476(TRAF6)
PGIG: 120606104(TRAF6)
PVP: 105290063(TRAF6)
RAY: 107499247(TRAF6)
MJV: 108390300(TRAF6)
TOD: 119255354(TRAF6)
SARA: 101543216(TRAF6)
SETR: 126017923(TRAF6)
LAV: 100671471(TRAF6)
TMU: 101345331
ETF: 101658809(TRAF6)
DNM: 101438500(TRAF6)
MDO: 100010055(TRAF6)
GAS: 123251329(TRAF6)
SHR: 100922331(TRAF6)
AFZ: 127542124
PCW: 110192620(TRAF6)
TVP: 118853553(TRAF6)
OAA: 100077058(TRAF6)
GGA: 423163(TRAF6)
PCOC: 116229116(TRAF6)
MGP: 100544809(TRAF6)
CJO: 107314700(TRAF6)
TPAI: 128085633(TRAF6)
LMUT: 125694458(TRAF6)
NMEL: 110401104(TRAF6)
APLA: 101802411(TRAF6)
ACYG: 106044346(TRAF6)
CATA: 118250786(TRAF6)
AFUL: 116489674(TRAF6)
TGU: 100229606(TRAF6)
LSR: 110484454(TRAF6)
SCAN: 103826724(TRAF6)
PMOA: 120512561(TRAF6)
OTC: 121344869(TRAF6)
PRUF: 121360996(TRAF6)
GFR: 102040197(TRAF6)
FAB: 101817601(TRAF6)
OMA: 130253546(TRAF6)
PHI: 102105183(TRAF6)
PMAJ: 107206210(TRAF6)
CCAE: 111930105(TRAF6)
CCW: 104693976(TRAF6)
CBRC: 103620910(TRAF6)
ETL: 114056738(TRAF6)
ZAB: 102065554(TRAF6)
ZLE: 135448458(TRAF6)
ACHL: 103802335(TRAF6)
SVG: 106851517(TRAF6)
MMEA: 130578096(TRAF6)
HRT: 120754032(TRAF6)
SATI: 136362483(TRAF6)
FPG: 101912003(TRAF6)
FCH: 102058044(TRAF6)
CCRI: 104154446(TRAF6)
NNT: 104402000(TRAF6)
SHAB: 115606662(TRAF6)
ACUN: 113481145(TRAF6)
TALA: 104369526(TRAF6)
ACHC: 115353383(TRAF6)
HALD: 104316940(TRAF6)
HLE: 104843213(TRAF6)
AGEN: 126049491
GCL: 127017259
CSTI: 104556332(TRAF6)
LDI: 104350177(TRAF6)
MNB: 103776764(TRAF6)
DPUB: 104304786(TRAF6)
AVIT: 104277489(TRAF6)
BRHI: 104495856(TRAF6)
EGZ: 104134046(TRAF6)
NNI: 104019573
PCRI: 104023738(TRAF6)
PCAO: 104039330(TRAF6)
PADL: 103921676(TRAF6)
AFOR: 103901553(TRAF6)
FGA: 104070053(TRAF6)
GSTE: 104254122(TRAF6)
CLV: 102083770(TRAF6)
MUI: 104548272(TRAF6)
PGUU: 104457452(TRAF6)
PLET: 104618120(TRAF6)
EHS: 104502487(TRAF6)
CMAC: 104480420(TRAF6)
CUCA: 104056322(TRAF6)
TEO: 104382441(TRAF6)
BREG: 104641124(TRAF6)
OHA: 104330076(TRAF6)
ACAR: 104523193(TRAF6)
CPEA: 104388407(TRAF6)
CVF: 104295805(TRAF6)
RTD: 128908737(TRAF6)
AAM: 106498355(TRAF6)
AROW: 112960908(TRAF6)
NPD: 112943501(TRAF6)
TGT: 104574137(TRAF6)
SCAM: 104152881(TRAF6)
ASN: 102368234(TRAF6)
AMJ: 102572036(TRAF6)
CPOO: 109321438(TRAF6)
GGN: 109298950(TRAF6)
PSS: 102463398(TRAF6)
CMY: 102938959(TRAF6)
CCAY: 125637892(TRAF6)
DCC: 119856996(TRAF6)
CPIC: 101953645(TRAF6)
TST: 117877000(TRAF6)
CABI: 116839265(TRAF6)
MRV: 120404545(TRAF6)
ACS: 100561211(traf6)
ASAO: 132768609(TRAF6)
PVT: 110090250(TRAF6)
SUND: 121929536(TRAF6)
PBI: 103052063(TRAF6)
PMUR: 107293338(TRAF6)
CTIG: 120301920(TRAF6)
TSR: 106556967(TRAF6)
PGUT: 117665476(TRAF6)
APRI: 131187423(TRAF6)
PTEX: 113440701(TRAF6)
NSS: 113410230(TRAF6)
VKO: 123026693(TRAF6)
PMUA: 114600173(TRAF6)
PRAF: 128416982(TRAF6)
ZVI: 118089981(TRAF6)
HCG: 128341705(TRAF6)
GJA: 107116985(TRAF6)
STOW: 125434925
EMC: 129323951(TRAF6)
XLA: 444777(traf6.L) 734929(traf6.S)
XTR: 493524(traf6)
NPR: 108787821(TRAF6)
RTEM: 120917068(TRAF6)
BBUF: 120980714(TRAF6)
BGAR: 122920378(TRAF6)
MUO: 115468800(TRAF6)
GSH: 117351994(TRAF6)
DRE: 554561(traf6)
CCAR: 109065463 109093401(traf6)
PTET: 122349485(traf6)
LROH: 127168474(traf6)
OMC: 131543819(traf6)
PPRM: 120469276(traf6)
RKG: 130077123(traf6)
MAMB: 125265141(traf6)
CIDE: 127515905
CERY: 137031225(traf6)
TROS: 130561567(traf6)
TDW: 130427828(traf6)
MANU: 129447218(traf6)
IPU: 108259200
IFU: 128603046(traf6)
PHYP: 113540966(traf6)
SMEO: 124379888(traf6)
TFD: 113636662(traf6)
TVC: 132838745(traf6)
AMEX: 103021325(traf6)
CMAO: 118817529(traf6)
EEE: 113579696(traf6)
CHAR: 105889045(traf6) 105913349
TRU: 101071368(traf6)
TFS: 130515755(traf6)
LCO: 104920634(traf6)
NCC: 104948752(traf6)
TBEN: 117471647(traf6)
CGOB: 115025996(traf6)
PGEO: 117463949(traf6)
GACU: 117549320(traf6)
EMAC: 134863706(traf6)
ELY: 117257648(traf6)
EFO: 125900030(traf6)
PLEP: 121946204(traf6)
SLUC: 116043440(traf6)
ECRA: 117948342(traf6)
ESP: 116689192(traf6)
PFLV: 114552813(traf6)
GAT: 100174890(traf6)
PPUG: 119228078(traf6)
AFB: 129101016(traf6)
CLUM: 117749526(traf6)
PSWI: 130192387(traf6)
MSAM: 119889757(traf6)
SCHU: 122870990(traf6)
CUD: 121513662(traf6)
ALAT: 119017781(traf6)
MZE: 101469001(traf6)
ONL: 100703551(traf6)
OAU: 116329465(traf6)
OLA: 101161132(traf6)
OML: 112161172(traf6)
CSAI: 133458825(traf6)
XMA: 102220826(traf6)
XCO: 114142760(traf6)
XHE: 116718296(traf6)
PRET: 103462724(traf6)
PFOR: 103153578(traf6)
PLAI: 106965102(traf6)
PMEI: 106907132(traf6)
GAF: 122845565(traf6)
PPRL: 129364077(traf6)
CVG: 107099447(traf6)
CTUL: 119773575(traf6)
GMU: 124866796(traf6)
NFU: 107383589(traf6)
KMR: 108234801(traf6)
ALIM: 106523547(traf6)
NWH: 119430243(traf6)
AOCE: 111571002(traf6)
MCEP: 125005122(traf6)
CSEM: 103378810(traf6)
POV: 109637261(traf6)
SSEN: 122772221(traf6)
HHIP: 117754467(traf6)
HSP: 118106693(traf6)
PPLT: 128450547(traf6)
SMAU: 118302102(traf6)
LCF: 108887802
SDU: 111223588(traf6)
SLAL: 111644323(traf6)
XGL: 120788717(traf6)
HCQ: 109525774(traf6)
SSCV: 125967623
SBIA: 133498402(traf6)
PEE: 133399116(traf6)
PTAO: 133471939(traf6)
BPEC: 110162549(traf6)
MALB: 109965061(traf6)
BSPL: 114852159(traf6)
SJO: 128382417(traf6)
OTW: 112247822(traf6)
ONE: 115117991
OKI: 109877755(traf6) 116365776
OKE: 118381203(traf6)
SALP: 112077783(traf6)
CCLU: 121546400(traf6)
ELS: 105025313(traf6)
SFM: 108934700 108942315(traf6)
AANG: 118215287(traf6)
LOC: 102684182(traf6)
PSEX: 120523208(traf6)
LCM: 102353931(TRAF6)
CMK: 103186026(traf6) 121852210
RTP: 109936672(traf6)
CPLA: 122557956(traf6)
HOC: 132824362(traf6)
LERI: 129705871(traf6)
PMRN: 116945680(TRAF6)
LRJ: 133351359
BFO: 118414689
CIN: 778949(zf(traf/ring)-3)
SCLV: 120333900
ARUN: 117292195
DME: Dmel_CG10961(Traf6)
DER: 6550517
DSE: 6620179
DSI: Dsimw501_GD16124(Dsim_GD16124)
DSR: 110179707
DPO: 4814971
DPE: 6598159
DMN: 108164693
DWI: 6641099
DGR: 6565995
DAZ: 108617878
DNV: 108655545
DHE: 111594992
DVI: 6632039
CCAT: 101456087
BOD: 106618464
BDR: 105232033
RZE: 108364599
AOQ: 129239603
TDA: 119669766
MDE: 101890213
SCAC: 106087456
LCQ: 111674929
GFS: 119641147
ECOE: 129948038
HIS: 119654244
AGA: 1272949
ACOZ: 120961031
AARA: 120897145
AMER: 121600145
ASTE: 118503584
AFUN: 125765449
AMOU: 128310802
AALI: 118459068
BCOO: 119071533
AME: 551819
ACER: 107994913
ALAB: 122713429
ADR: 102675349
AFLR: 100867190
BIM: 100744070
BBIF: 117215675
BVK: 117238330
BVAN: 117164721
BTER: 100647374
BAFF: 126914697
BPYO: 122566488
BPAS: 132909841
FVI: 122538191
CCAL: 108622235
OBB: 114881674
OLG: 117609805
MGEN: 117219535
NMEA: 116428933
CGIG: 122405097
SOC: 105198280
MPHA: 105833603
AEC: 105149418
ACEP: 105625455
PBAR: 105422477
VEM: 105567281
HST: 105190721
DQU: 106742594
CFO: 105257286
FEX: 115238130
LHU: 105676050(Traf6)
PGC: 109851970
OBO: 105280100
PCF: 106788531
PFUC: 122518063
VPS: 122628097
VCRB: 124422504
VVE: 124947452
LHT: 122501544
LBD: 127281180
MDL: 103569690
FAS: 105267067
DAM: 107039233
AGIF: 122854142
VCAN: 122405899
CCIN: 107268152
DSM: 124412632
NPT: 124220832
NFB: 124184215
NLO: 107222633
NVG: 124306602
AROA: 105694090
TCA: 661716(Traf2)
DPA: 109541363
SOY: 115874728
AGRG: 126741656
ATD: 109597958
CSET: 123309084
AGB: 108911878
LDC: 111504407
DVV: 114329212
NVL: 108556858
APLN: 108733106
OTU: 111413061
BMOR: 100862757
BMAN: 114241799
BANY: 112046594
MJU: 123866044
NIQ: 126768147
VCD: 124544401
MCIX: 123670312
PMAC: 106715656
PPOT: 106103347
PXU: 106113379
PRAP: 111001407
PBX: 123711294
PNAP: 125059331
ZCE: 119833545
CCRC: 123692171
LSIN: 126976964
AAGE: 121728824
HAW: 110371014
HZE: 124632749
TNL: 113507105
SLIU: 111358584
OFU: 114364070
ATRA: 106134559
GMW: 113523388
PXY: 105382485
PGW: 126366285
LGLY: 125228817
CCRN: 123299236
API: 100575177
DNX: 107165263
AGS: 114120558
RMD: 113560984
ACOO: 126843453
DVT: 126900212
BTAB: 109044603
CLEC: 106670044
HHAL: 106683518
NLU: 111046887
HVI: 124364591
FOC: 113213546
TPAL: 117647796
ZNE: 110826527
CSEC: 111863746
BROR: 134536230
FCD: 110850863
PVM: 113823573
PJA: 122259149
PCHN: 125035846
PMOO: 119594067
HAME: 121877642
PCLA: 123761643
CQD: 128686024
PTRU: 123518241
ESN: 127010133
MNZ: 135207206
HAZT: 108680316
EAF: 111700075
LSM: 121126234
TCF: 131889650
PPOI: 119107386
ISC: 115308616
DFR: 124495251
CSCU: 111628924
LPOL: 106469125
GAE: 121380421
PMAX: 117327240
MMER: 123563068
DPOL: 127866356
NVE: 5520915
HSY: 130612339
RES: 135695645
MAW: 19250075(J3458_011743)
MAJ: MAA_01724
CMT: CCM_08969
PLJ: 28889425(PLICBS_008135)
 » show all
Reference
  Authors
Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, Hur L, Grabiner BC, Lin X, Darnay BG, Lin HK
  Title
The E3 ligase TRAF6 regulates Akt ubiquitination and activation.
  Journal
Science 325:1134-8 (2009)
DOI:10.1126/science.1175065
  Sequence
[hsa:7189]
Reference
PMID:8837778
  Authors
Cao Z, Xiong J, Takeuchi M, Kurama T, Goeddel DV
  Title
TRAF6 is a signal transducer for interleukin-1.
  Journal
Nature 383:443-6 (1996)
DOI:10.1038/383443a0
  Sequence
[hsa:7189]

KEGG   ORTHOLOGY: K09848
Entry
K09848                      KO                                     
Symbol
TRAF4
Name
TNF receptor-associated factor 4
Pathway
map04214  Apoptosis - fly
map04657  IL-17 signaling pathway
map05200  Pathways in cancer
map05222  Small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04214 Apoptosis - fly
    K09848  TRAF4; TNF receptor-associated factor 4
 09150 Organismal Systems
  09151 Immune system
   04657 IL-17 signaling pathway
    K09848  TRAF4; TNF receptor-associated factor 4
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K09848  TRAF4; TNF receptor-associated factor 4
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K09848  TRAF4; TNF receptor-associated factor 4
Genes
HSA: 9618(TRAF4)
PTR: 454534(TRAF4) 471682
PPS: 100975513(TRAF4) 134730482
GGO: 101142858(TRAF4)
PON: 100431446(TRAF4)
PPYG: 129017864(TRAF4)
NLE: 100607896(TRAF4)
HMH: 116470627 116474596(TRAF4)
SSYN: 129469782(TRAF4) 129485731
MCC: 716364(TRAF4)
MCF: 102146475(TRAF4) 135971526
MNI: 105476400(TRAF4)
CSAB: 103242634(TRAF4)
CATY: 105591534(TRAF4)
PANU: 100998010(TRAF4) 101012840
TGE: 112609875(TRAF4)
MLEU: 105552020(TRAF4)
RRO: 104674107(TRAF4)
RBB: 108530161 108539936(TRAF4)
TFN: 117066115 117066440(TRAF4)
PTEH: 111520789(TRAF4)
CANG: 105510844(TRAF4)
CJC: 100404035(TRAF4)
SBQ: 101050448(TRAF4)
CIMI: 108313656(TRAF4)
ANAN: 105715113(TRAF4)
CSYR: 103269140(TRAF4)
MMUR: 105857888(TRAF4)
LCAT: 123620262(TRAF4)
PCOQ: 105813515(TRAF4)
OGA: 100948546(TRAF4)
MMU: 22032(Traf4)
MCAL: 110305822(Traf4)
MPAH: 110331517(Traf4)
RNO: 303285(Traf4)
MCOC: 116078917(Traf4)
ANU: 117711719(Traf4)
MUN: 110544618(Traf4)
CGE: 100762863(Traf4)
MAUA: 101832293(Traf4)
PROB: 127218862(Traf4)
PLEU: 114691489(Traf4)
MORG: 121439731 121457042(Traf4)
MFOT: 126492289
AAMP: 119813293(Traf4)
NGI: 103730465(Traf4)
HGL: 101716536(Traf4)
CPOC: 100723177(Traf4)
CCAN: 109685873(Traf4)
DORD: 105985848(Traf4)
DSP: 122117999(Traf4)
PLOP: 125365843(Traf4)
MMMA: 107155151(Traf4)
OCU: 100344600
OPI: 101519553(TRAF4)
TUP: 102496823(TRAF4)
GVR: 103598599(TRAF4)
CFA: 100688511(TRAF4)
CLUD: 112677650(TRAF4)
VVP: 112933128(TRAF4)
VLG: 121473018(TRAF4)
NPO: 129517250(TRAF4)
AML: 100464464(TRAF4)
UMR: 103667407(TRAF4)
UAH: 113269047(TRAF4)
UAR: 123776940(TRAF4)
ELK: 111151781
LLV: 125087052
MPUF: 101680334(TRAF4)
MNP: 132004224(TRAF4)
MLK: 131816559(TRAF4)
NVS: 122906399(TRAF4)
ORO: 101366008(TRAF4)
EJU: 114214005(TRAF4)
ZCA: 113939327(TRAF4)
MLX: 118025276(TRAF4)
NSU: 110592964(TRAF4)
FCA: 101096365(TRAF4)
PYU: 121017224(TRAF4)
PCOO: 112855155(TRAF4)
PBG: 122485148(TRAF4)
PVIV: 125151850(TRAF4)
LRUF: 124512882
PTG: 102951157(TRAF4)
PPAD: 109251836(TRAF4)
PUC: 125926832
AJU: 106983231
HHV: 120246612(TRAF4)
BTA: 781568(TRAF4)
BOM: 102269869(TRAF4)
BBUB: 102410311(TRAF4)
BBIS: 105003942(TRAF4)
CHX: 102169328(TRAF4)
OAS: 101107451(TRAF4)
BTAX: 128065129(TRAF4)
CCAD: 122448357(TRAF4)
MBEZ: 129540764(TRAF4)
SSC: 100518396(TRAF4)
CFR: 102507612(TRAF4)
CBAI: 105071559(TRAF4)
CDK: 105088169(TRAF4)
VPC: 102527080(TRAF4)
BACU: 103020623(TRAF4)
BMUS: 118886607(TRAF4)
LVE: 103082299(TRAF4)
OOR: 101273760(TRAF4)
DLE: 111185690(TRAF4)
PCAD: 102978993(TRAF4)
PSIU: 116745209(TRAF4)
NASI: 112394521(TRAF4)
ECB: 100072085(TRAF4)
EPZ: 103555959(TRAF4)
EAI: 106844533(TRAF4)
MYB: 102240047(TRAF4)
MYD: 102768459(TRAF4)
MMYO: 118671843(TRAF4)
MLF: 102432859(TRAF4)
MDT: 132218300(TRAF4)
PKL: 118702605(TRAF4)
EFUS: 103291725(TRAF4)
MNA: 107528737(TRAF4)
DRO: 112308504(TRAF4)
SHON: 119003465(TRAF4)
AJM: 119062023(TRAF4)
PDIC: 114503219(TRAF4)
PHAS: 123817690(TRAF4)
MMF: 118634970(TRAF4)
PPAM: 129070308(TRAF4)
HAI: 109385156(TRAF4)
RFQ: 117013039(TRAF4)
PALE: 102896659(TRAF4)
PGIG: 120620971(TRAF4)
PVP: 105291906(TRAF4)
RAY: 107507775(TRAF4)
MJV: 108383991(TRAF4)
TOD: 119232889(TRAF4)
SARA: 101551642(TRAF4)
SETR: 126008011(TRAF4)
LAV: 100660891(TRAF4)
TMU: 101356495
ETF: 101653562(TRAF4)
DNM: 101426030(TRAF4)
MDO: 100020121(TRAF4)
GAS: 123246797(TRAF4)
SHR: 100932711(TRAF4)
AFZ: 127558912
PCW: 110192193(TRAF4)
TVP: 118858665(TRAF4)
OAA: 100681634(TRAF4)
GGA: 417577(TRAF4)
PCOC: 116228054(TRAF4)
MGP: 100540312(TRAF4)
CJO: 107322689(TRAF4)
TPAI: 128083733(TRAF4)
LMUT: 125702971(TRAF4)
NMEL: 110407752(TRAF4)
APLA: 113845664(TRAF4)
ACYG: 106049412(TRAF4)
CATA: 118255094(TRAF4)
AFUL: 116497288(TRAF4)
TGU: 100227147(TRAF4)
LSR: 110482014(TRAF4)
SCAN: 103820296(TRAF4)
PMOA: 120507669(TRAF4)
OTC: 121345800(TRAF4)
PRUF: 121361845(TRAF4)
GFR: 102038680(TRAF4)
FAB: 101817428(NEK8)
OMA: 130260790(TRAF4)
PHI: 102112684(TRAF4)
PMAJ: 107212657(TRAF4)
CCAE: 111937949(TRAF4)
CCW: 120411032(TRAF4)
CBRC: 103616264(TRAF4)
ETL: 114061249(TRAF4)
ZAB: 102070669(TRAF4)
ZLE: 135455901(TRAF4)
ACHL: 103810160(TRAF4)
SVG: 106853285(TRAF4)
MMEA: 130576979(TRAF4)
HRT: 120761329(TRAF4)
SATI: 136370117(TRAF4)
FPG: 101915588(TRAF4)
FCH: 102058322(TRAF4)
CCRI: 104167363(TRAF4)
NNT: 104410839(TRAF4)
SHAB: 115601935(TRAF4)
ACUN: 113487313(TRAF4)
TALA: 116964432(TRAF4)
ACHC: 115347565(TRAF4)
HLE: 104835588(TRAF4)
AGEN: 126039145
GCL: 127024467
LDI: 104342273(TRAF4)
MNB: 103774124(TRAF4)
DPUB: 104302772(TRAF4)
AVIT: 104280272(TRAF4)
EGZ: 104131856(TRAF4)
NNI: 104012773(TRAF4)
AFOR: 103898101(TRAF4)
FGA: 104072933(TRAF4)
CLV: 102090831(TRAF4)
MUI: 104546588(TRAF4)
PGUU: 104460907(TRAF4)
CUCA: 104058724(TRAF4)
BREG: 104631890(TRAF4)
OHA: 104332828(TRAF4)
ACAR: 104523560(TRAF4)
CPEA: 104397359(TRAF4)
CVF: 104288432(TRAF4)
RTD: 128912933(TRAF4)
AAM: 106487791(TRAF4)
AROW: 112960751(TRAF4)
NPD: 112954609(TRAF4)
DNE: 112986364(TRAF4)
ASN: 102371929(TRAF4)
AMJ: 102574069(TRAF4)
GGN: 109293374(TRAF4)
CMY: 102940376(TRAF4)
CCAY: 125624065(TRAF4)
DCC: 119844788(TRAF4)
CPIC: 101937641(TRAF4)
TST: 117867594(TRAF4)
CABI: 116829734(TRAF4)
MRV: 120387148(TRAF4)
ACS: 103278073
ASAO: 132763291(TRAF4)
PVT: 110084287(TRAF4)
SUND: 121916805(TRAF4)
PBI: 103063535(TRAF4)
PMUR: 107298393(TRAF4) 107300072
CTIG: 120318176(TRAF4)
TSR: 106551046(TRAF4)
PGUT: 117669809(TRAF4)
APRI: 131188588(TRAF4)
PTEX: 113454554(TRAF4)
VKO: 123023644(TRAF4)
PMUA: 114585136(TRAF4)
PRAF: 128402823(TRAF4)
ZVI: 118096944(TRAF4)
HCG: 128335989(TRAF4)
GJA: 107119394(TRAF4)
STOW: 125445930(TRAF4)
EMC: 129344505(TRAF4)
XLA: 446373(traf4.S) 447325(traf4.L)
XTR: 448646(traf4)
NPR: 108785865(TRAF4)
RTEM: 120927696(TRAF4)
BBUF: 120994672(TRAF4)
BGAR: 122930418(TRAF4)
MUO: 115456578(TRAF4)
GSH: 117349268(TRAF4)
DRE: 404035(traf4b) 404045(traf4a)
PTET: 122326953(traf4b) 122359056(traf4a)
LROH: 127152990(traf4b) 127177378(traf4a)
OMC: 131520788(traf4a) 131528444(traf4b)
PPRM: 120478815(traf4a) 120482998(traf4b)
RKG: 130077796(traf4a) 130095462(traf4b)
MAMB: 125248399(traf4a) 125252734(traf4b)
CERY: 137004304(traf4a) 137013207(traf4b)
TROS: 130564886(traf4a) 130569698
TDW: 130408455(traf4b) 130429234(traf4a)
MANU: 129423426(traf4b) 129437810(traf4a)
IPU: 108277967(traf4a) 108279198(traf4b)
IFU: 128621253(traf4a) 128621970(traf4b)
PHYP: 113532979(traf4) 113541461
SMEO: 124394955(traf4a) 124398202(traf4b)
TFD: 113636744(traf4a) 113662491(traf4b)
TVC: 132857675(traf4a) 132859791 132860302(traf4b)
TRN: 134330470(traf4b) 134334655(traf4a)
AMEX: 103024022(traf4a) 103043275(traf4b)
CMAO: 118799430(traf4a) 118820422(traf4b)
CHAR: 105911029(traf4a)
TRU: 101079223(traf4)
TFS: 130534935(traf4a)
LCO: 104933840(traf4)
NCC: 104947740(traf4)
TBEN: 117468749(traf4a)
CGOB: 115018135(traf4)
PGEO: 117457740(traf4a)
GACU: 117540389(traf4a)
EMAC: 134880577(traf4a)
ELY: 117260233(traf4a)
EFO: 125888377(traf4a)
PLEP: 121943609(traf4a)
SLUC: 116048463(traf4a)
ECRA: 117942064(traf4a)
ESP: 116683162(traf4)
PFLV: 114553312(traf4)
GAT: 120821517(traf4a)
PPUG: 119211579(traf4a)
AFB: 129092181(traf4a)
CLUM: 117741943(traf4a)
PSWI: 130210966(traf4a)
MSAM: 119882582(traf4a)
SCHU: 122878428(traf4a)
CUD: 121524632(traf4a)
ALAT: 119010092(traf4a)
MZE: 101478516(traf4)
ONL: 100692866(traf4)
OAU: 116313869(traf4a)
OLA: 101161428(traf4)
OML: 112149230(traf4a)
CSAI: 133441890(traf4a)
XMA: 102237563(traf4)
XCO: 114161854(traf4)
XHE: 116737494(traf4)
PRET: 103474150(traf4)
PFOR: 103148535(traf4)
PLAI: 106963640(traf4)
PMEI: 106932491(traf4)
GAF: 122832115(traf4a)
PPRL: 129369758(traf4a)
CVG: 107090393(traf4)
CTUL: 119795376(traf4a)
GMU: 124883834(traf4a)
NFU: 107379986(traf4)
KMR: 108247288(traf4a)
ALIM: 106528834(traf4)
NWH: 119410703(traf4a)
AOCE: 111580070(traf4)
MCEP: 125013546(traf4a)
CSEM: 103378251(traf4)
POV: 109630346(traf4)
SSEN: 122773556(traf4a)
HHIP: 117772930(traf4a)
HSP: 118106284(traf4a)
PPLT: 128440683(traf4a)
SMAU: 118299219(traf4a)
LCF: 108876091(traf4a)
SDU: 111232339(traf4)
SLAL: 111649109(traf4)
XGL: 120791554(traf4a)
HCQ: 109514842(traf4)
SSCV: 125972663
SBIA: 133504965(traf4a)
PEE: 133404850(traf4a)
PTAO: 133482010(traf4a)
BPEC: 110163593(traf4)
MALB: 109972100(traf4)
BSPL: 114867697(traf4a)
SJO: 128360744(traf4a)
SASA: 100380313(traf4) 106581191
OTW: 112265512 112267086(traf4a)
OGO: 123992749 124005598(traf4a)
ELS: 105024873(traf4)
AANG: 118236618
LOC: 102689292(traf4)
PSPA: 121306730 121308777(traf4a)
PSEX: 120530664
LCM: 102365594(TRAF4)
CMK: 103183364
RTP: 109930293
CPLA: 122563987
HOC: 132830335
LERI: 129710886(traf4a)
PMRN: 116936827(TRAF4)
CIN: 100169997(zf(traf/ring)-2) 100178442 778947(zf(traf/ring)-1)
AJC: 117118417
DME: Dmel_CG3048(Traf4)
DER: 6541238
DSI: Dsimw501_GD23279(Dsim_GD23279)
DYA: Dyak_GE18283(Dyak_Traf1)
DSR: 110185800
DPO: 6903170
DPE: 6595471
DMN: 108162829
DWI: 6644043
DGR: 6566746
DAZ: 108611678
DNV: 115562653
DHE: 111599081
CCAT: 101460778
BOD: 106627520
BDR: 115065719
RZE: 108369433
AOQ: 129248248
TDA: 119662180
MDE: 101887819
SCAC: 106087243
LCQ: 111680454
LSQ: 119599747
GFS: 119634248
ECOE: 129951246
HIS: 119661701
AGA: 1279446
ACOZ: 120957710
AARA: 120903095
AMER: 121596811
ASTE: 118508928
AFUN: 125765245
AMOU: 128304233
AALI: 118456437
AAG: 5568228
ASUA: 134212049
CPII: 120415481
BCOO: 119066457
AME: 408754
ACER: 107992533
ALAB: 122712715
ADR: 102680234
AFLR: 100865449
BIM: 100744208
BBIF: 117205853
BVK: 117235334
BVAN: 117153791
BTER: 100650432
BAFF: 126916945
BPYO: 122566260
BPAS: 132905305
FVI: 122535791
CCAL: 108626367
OLG: 117605127
MGEN: 117222343
NMEA: 116434921
CGIG: 122398131
SOC: 105201954
MPHA: 105837024
AEC: 105149400
ACEP: 105627101
PBAR: 105427763
VEM: 105561586
HST: 105192294
DQU: 106747085
CFO: 105256304
FEX: 115236160
LHU: 105672091(Traf4)
PGC: 109863288
OBO: 105280979
PCF: 106789485
PFUC: 122525638
VPS: 122633326
VCRB: 124429571
VVE: 124953904
NVI: 100118814
CSOL: 105369003
TPRE: 106655714
MDL: 103574379
CGLO: 123264632
FAS: 105270021
DAM: 107040956
AGIF: 122858359
CINS: 118071265
VCAN: 122414993
CCIN: 107271545
DSM: 124410565
NPT: 124220033
NFB: 124183856
NLO: 107217528
NVG: 124306306
AROA: 105686210
TCA: 655880
DPA: 109543490
SOY: 115884779
AGRG: 126746411
ATD: 109595509
CSET: 123313839
AGB: 108903687
LDC: 111509113
DVV: 114328800
NVL: 108569948
APLN: 108744569
PPYR: 116177176
OTU: 111426926
BMOR: 101737830
BMAN: 114241678
MSEX: 115454859
BANY: 112051077
MJU: 123878477
NIQ: 126770193
VCD: 124533675
MCIX: 123653938
PMAC: 106716301
PXU: 106127216
PRAP: 110997409
PBX: 123720637
PNAP: 125054525
ZCE: 119834760
CCRC: 123691076
LSIN: 126974947
AAGE: 121731774
HAW: 110369716
HZE: 124631009
TNL: 113508819
SLIU: 111352123
OFU: 114358287
ATRA: 106139355
GMW: 113517246
PXY: 105380927
PGW: 126367798
LGLY: 125228102
CFEL: 113389223
CCRN: 123295434
API: 100159489
DNX: 107171845
AGS: 114120242
RMD: 113550630
ACOO: 126845551
DVT: 126895267
BTAB: 109039714
DCI: 103507530
CLEC: 106663763
HHAL: 106681134(Traf4)
NLU: 111063180
HVI: 124367700
FOC: 113205001
ZNE: 110831213
CSEC: 111873461
SGRE: 126339564
BROR: 134540428
IEL: 124159431
DMK: 116917410
DPZ: 124314718
LSM: 121125433
TCF: 131882356
PPOI: 119109616
ISC: 120836810
PTEP: 107445628
ABRU: 129966581
UDV: 129223247
SDM: 118196825
CEL: CELE_F45G2.6(trf-1) CELE_Y110A7A.2(trf-2)
CBR: CBG_21219(Cbr-trf-1) CBG_23748
PCAN: 112562574
HRF: 124135183
HRJ: 124273421
MCAF: 127711783
OBI: 106871852
OSN: 115224855
LJP: 135476563
SHX: MS3_00003647(TRAF4_2)
EGL: EGR_10095
 » show all
Reference
PMID:7490069
  Authors
Tomasetto C, Regnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC
  Title
Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17.
  Journal
Genomics 28:367-76 (1995)
DOI:10.1006/geno.1995.1163
  Sequence
[hsa:9618]
Reference
  Authors
Xu YC, Wu RF, Gu Y, Yang YS, Yang MC, Nwariaku FE, Terada LS
  Title
Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase.
  Journal
J Biol Chem 277:28051-7 (2002)
DOI:10.1074/jbc.M202665200
  Sequence
[hsa:9618]

KEGG   ORTHOLOGY: K03172
Entry
K03172                      KO                                     
Symbol
TRAF1
Name
TNF receptor-associated factor 1
Pathway
map04064  NF-kappa B signaling pathway
map04210  Apoptosis
map04668  TNF signaling pathway
map05200  Pathways in cancer
map05202  Transcriptional misregulation in cancer
map05203  Viral carcinogenesis
map05222  Small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K03172  TRAF1; TNF receptor-associated factor 1
   04668 TNF signaling pathway
    K03172  TRAF1; TNF receptor-associated factor 1
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K03172  TRAF1; TNF receptor-associated factor 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03172  TRAF1; TNF receptor-associated factor 1
   05202 Transcriptional misregulation in cancer
    K03172  TRAF1; TNF receptor-associated factor 1
   05203 Viral carcinogenesis
    K03172  TRAF1; TNF receptor-associated factor 1
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K03172  TRAF1; TNF receptor-associated factor 1
Genes
HSA: 7185(TRAF1)
PTR: 743748(TRAF1)
PPS: 100985558(TRAF1)
GGO: 101126795(TRAF1)
PON: 100172676(TRAF1)
PPYG: 129044168(TRAF1)
NLE: 100605879(TRAF1)
SSYN: 129478948(TRAF1)
MCC: 700583(TRAF1)
MTHB: 126936852
MNI: 105487148(TRAF1)
CSAB: 103218917(TRAF1)
CATY: 105600240(TRAF1)
PANU: 101001256(TRAF1)
TGE: 112608030(TRAF1)
MLEU: 105546333(TRAF1)
RRO: 104669131(TRAF1)
RBB: 108537107(TRAF1)
TFN: 117098744(TRAF1)
PTEH: 111550331(TRAF1)
CANG: 105501437(TRAF1)
CJC: 100389116(TRAF1)
SBQ: 101041198(TRAF1)
CIMI: 108285843(TRAF1)
ANAN: 105721249(TRAF1)
CSYR: 103258026(TRAF1)
MMUR: 105875121(TRAF1)
LCAT: 123646265(TRAF1)
PCOQ: 105826431(TRAF1)
OGA: 100959720(TRAF1)
MMU: 22029(Traf1)
MCAL: 110289943(Traf1)
MPAH: 110319363(Traf1)
RNO: 687813(Traf1)
MCOC: 116090053(Traf1)
ANU: 117703605(Traf1)
MUN: 110563759(Traf1)
CGE: 100756802(Traf1)
MAUA: 101825347(Traf1)
PROB: 127222814(Traf1)
PLEU: 114704682(Traf1)
MORG: 121463026(Traf1)
MFOT: 126513423
AAMP: 119819361(Traf1)
NGI: 103734496(Traf1)
HGL: 101710804(Traf1)
CPOC: 100723139(Traf1)
CCAN: 109699424(Traf1)
DORD: 105996183(Traf1)
DSP: 122107096(Traf1)
PLOP: 125347818(Traf1)
NCAR: 124964504
MMMA: 107152135(Traf1)
OCU: 100338847
OPI: 101532077(TRAF1)
TUP: 102493987(TRAF1)
GVR: 103587301(TRAF1)
VVP: 112923107(TRAF1)
VLG: 121495157(TRAF1)
NPO: 129494886(TRAF1)
AML: 100464979(TRAF1)
UMR: 103670373(TRAF1)
UAH: 113266352(TRAF1)
UAR: 123788020(TRAF1)
ELK: 111146115
LLV: 125083470
MPUF: 101682095(TRAF1)
MNP: 132024461(TRAF1)
MLK: 131812230(TRAF1)
NVS: 122917303(TRAF1)
ORO: 101364536(TRAF1)
EJU: 114212777(TRAF1)
ZCA: 113934914(TRAF1)
MLX: 118017749(TRAF1)
NSU: 110581352(TRAF1)
LWW: 102731373(TRAF1)
FCA: 101087620(TRAF1)
PYU: 121034913(TRAF1)
PCOO: 112849250(TRAF1)
PBG: 122475453(TRAF1)
PVIV: 125150641(TRAF1)
LRUF: 124503618
PTG: 102961906(TRAF1)
PPAD: 109269887(TRAF1)
PUC: 125920844
AJU: 106986638
HHV: 120233425(TRAF1)
BTA: 540944(TRAF1)
BOM: 102287586(TRAF1)
BIU: 109563408(TRAF1)
BBUB: 102399965(TRAF1)
BBIS: 104994766(TRAF1)
CHX: 102182975(TRAF1)
OAS: 101122077(TRAF1)
BTAX: 128052448(TRAF1)
ODA: 120863585(TRAF1)
CCAD: 122431882(TRAF1)
MBEZ: 129557215(TRAF1)
SSC: 100627029(TRAF1)
CFR: 102511048(TRAF1)
CBAI: 105065268(TRAF1)
CDK: 105104470(TRAF1)
VPC: 102544593(TRAF1)
BACU: 103010571(TRAF1)
BMUS: 118897235(TRAF1)
LVE: 103085868(TRAF1)
OOR: 101279636(TRAF1)
DLE: 111177267(TRAF1)
PCAD: 102979844(TRAF1)
PSIU: 116755406(TRAF1)
NASI: 112411542(TRAF1)
ECB: 100067681(TRAF1)
EPZ: 103550396(TRAF1)
EAI: 106824204(TRAF1)
MYB: 102239036(TRAF1)
MYD: 102773676(TRAF1)
MMYO: 118667115(TRAF1)
MLF: 102441839(TRAF1)
MDT: 132212319(TRAF1)
PKL: 118716109(TRAF1)
EFUS: 103295679(TRAF1)
MNA: 107537677(TRAF1)
DRO: 112306476(TRAF1)
SHON: 118995980(TRAF1)
AJM: 119035933(TRAF1)
PDIC: 114507728(TRAF1)
PHAS: 123819750(TRAF1)
MMF: 118630181(TRAF1)
PPAM: 129079617(TRAF1)
HAI: 109385737(TRAF1)
RFQ: 117032180(TRAF1)
PALE: 102894412(TRAF1)
PGIG: 120605773(TRAF1)
PVP: 105292663(TRAF1)
RAY: 107516329(TRAF1)
MJV: 108391145(TRAF1)
TOD: 119230859(TRAF1)
SARA: 101558533(TRAF1)
SETR: 126009381(TRAF1)
LAV: 100656766(TRAF1)
TMU: 101350627
ETF: 101663447(TRAF1)
DNM: 101422831(TRAF1)
MDO: 100015491(TRAF1)
GAS: 123235384(TRAF1)
SHR: 100932053(TRAF1)
AFZ: 127550532
PCW: 110211345(TRAF1)
TVP: 118844085(TRAF1)
OAA: 100681677(TRAF1)
GGA: 417123(TRAF1)
PCOC: 116234352(TRAF1)
MGP: 100538378(TRAF1)
CJO: 107321799(TRAF1)
TPAI: 128074089(TRAF1)
LMUT: 125702711(TRAF1)
NMEL: 110406931(TRAF1)
APLA: 101796056(TRAF1)
ACYG: 106040726(TRAF1)
CATA: 118252329(TRAF1)
AFUL: 116496986(TRAF1)
TGU: 100230681(TRAF1)
LSR: 110477711(TRAF1)
SCAN: 103819114(TRAF1)
PMOA: 120512353(TRAF1)
OTC: 121337042(TRAF1)
PRUF: 121362439(TRAF1)
GFR: 102036248(TRAF1)
FAB: 101809418(TRAF1)
OMA: 130260072(TRAF1)
PHI: 102107913(TRAF1)
PMAJ: 107212135(TRAF1)
CCAE: 111937083(TRAF1)
CCW: 104688365(TRAF1)
CBRC: 103623221(TRAF1)
ETL: 114058491(TRAF1)
ZAB: 102064941(TRAF1)
ZLE: 135454957(TRAF1)
ACHL: 103800762(TRAF1)
SVG: 106855421(TRAF1)
MMEA: 130577534(TRAF1)
HRT: 120761904(TRAF1)
SATI: 136369831(TRAF1)
FPG: 101913584(TRAF1)
FCH: 102052322(TRAF1)
CCRI: 104163578(TRAF1)
NNT: 104400409(TRAF1)
SHAB: 115616989(TRAF1)
ACUN: 113486515(TRAF1)
TALA: 104359133(TRAF1)
ACHC: 115335383(TRAF1)
HALD: 104324578(TRAF1)
HLE: 104834011(TRAF1)
AGEN: 126052326
GCL: 127023670
CSTI: 104564210(TRAF1)
LDI: 104345080(TRAF1)
MNB: 103778558(TRAF1)
DPUB: 104306545(TRAF1)
AVIT: 104274851(TRAF1)
BRHI: 104495541(TRAF1)
EGZ: 104135230(TRAF1)
NNI: 104023308(TRAF1)
PCRI: 104029741
PCAO: 104050245(TRAF1)
PADL: 103915325(TRAF1)
AFOR: 103900025(TRAF1)
FGA: 104076045(TRAF1)
GSTE: 104263428(TRAF1)
CLV: 102092613(TRAF1)
MUI: 104534572(TRAF1)
PGUU: 104467616(TRAF1)
PLET: 104623850(TRAF1)
EHS: 104517346(TRAF1)
CMAC: 104482990(TRAF1)
CUCA: 104066958(TRAF1)
TEO: 104376451(TRAF1)
BREG: 104643637(TRAF1)
OHA: 104335132(TRAF1)
ACAR: 104533088(TRAF1)
CPEA: 104389884(TRAF1)
CVF: 104292915(TRAF1)
RTD: 128917512(TRAF1)
AROW: 112964305(TRAF1)
NPD: 112955786(TRAF1)
TGT: 104575841(TRAF1)
DNE: 112979923(TRAF1)
SCAM: 104148069(TRAF1)
ASN: 102376917 102377947(TRAF1)
AMJ: 102558770(TRAF1) 102567048
CPOO: 109314035(TRAF1)
GGN: 109293050(TRAF1)
PSS: 102463237(TRAF1)
CMY: 102929689(TRAF1)
DCC: 119844049(TRAF1)
CPIC: 101931215(TRAF1)
TST: 117889393(TRAF1)
CABI: 116817399(TRAF1)
MRV: 120386584(TRAF1)
ACS: 100553353
ASAO: 132763671(TRAF1) 132765668
SUND: 121936031(TRAF1)
PBI: 112541689(TRAF1)
CTIG: 120300733(TRAF1) 120314272
PGUT: 117665100(TRAF1) 117667931
APRI: 131186237(TRAF1)
PTEX: 113443808(TRAF1) 113449341
VKO: 123017945 123028171(TRAF1)
PMUA: 114589408(TRAF1) 114592055
ZVI: 118084277(TRAF1)
HCG: 128338826(TRAF1)
STOW: 125441533(TRAF1)
XTR: 101734662(traf1)
NPR: 108793651(TRAF1)
RTEM: 120913809(TRAF1)
BBUF: 120977869(TRAF1)
BGAR: 122946670
MUO: 115466229 115473001(TRAF1)
GSH: 117346871 117368254(TRAF1)
DRE: 100148503(traf1)
CAUA: 113107179
CGIB: 127964088
PTET: 122351114(traf1)
LROH: 127169182(traf1)
OMC: 131546362(traf1)
PPRM: 120474395(traf1)
RKG: 130091677(traf1)
MAMB: 125280000(traf1)
CIDE: 127517418
CERY: 137026262(traf1)
TROS: 130567998(traf1)
TDW: 130406992(traf1)
MANU: 129414620(traf1)
IPU: 108264960(traf1)
IFU: 128608121(traf1)
PHYP: 113534948
SMEO: 124399411(traf1)
TFD: 113645500(traf1)
TVC: 132854002(traf1)
TRN: 134317759(traf1)
AMEX: 103045252(traf1)
CMAO: 118813828(traf1)
EEE: 113577380
CHAR: 105890598(traf1)
SASA: 106585784
STRU: 115164885
OTW: 112248218(traf1)
OMY: 110525328(traf1)
OGO: 124034580(traf1)
ONE: 115111313
OKI: 109876020
OKE: 118392908(traf1)
SALP: 111973666
SNH: 120048862(traf1)
CCLU: 121550753 121584502(traf1)
ELS: 105014657
SFM: 108938498(traf1)
PKI: 111855439
AANG: 118237064(traf1)
LOC: 102684289(traf1)
PSPA: 121306720
PSEX: 120536057(traf1)
LCM: 102352896
CMK: 103184611(traf1)
RTP: 109912223(traf1)
CPLA: 122564882(traf1)
HOC: 132825871(traf1) 132825872
LERI: 129711827(traf1) 129711828
PMRN: 116942278
LRJ: 133349566
SKO: 102807924
ATEN: 116291959
RES: 135695068
 » show all
Reference
PMID:7859281
  Authors
Mosialos G, Birkenbach M, Yalamanchili R, VanArsdale T, Ware C, Kieff E
  Title
The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family.
  Journal
Cell 80:389-99 (1995)
DOI:10.1016/0092-8674(95)90489-1
  Sequence
[hsa:7185]
Reference
  Authors
Kato T Jr, Gotoh Y, Hoffmann A, Ono Y
  Title
Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1.
  Journal
Genes Cells 13:509-20 (2008)
DOI:10.1111/j.1365-2443.2008.01182.x
  Sequence
[hsa:7185] [mmu:22029]

KEGG   ORTHOLOGY: K03174
Entry
K03174                      KO                                     
Symbol
TRAF3
Name
TNF receptor-associated factor 3
Pathway
map04064  NF-kappa B signaling pathway
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04657  IL-17 signaling pathway
map04668  TNF signaling pathway
map04936  Alcoholic liver disease
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05164  Influenza A
map05165  Human papillomavirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05203  Viral carcinogenesis
map05222  Small cell lung cancer
map05417  Lipid and atherosclerosis
Disease
H02536  Infection-induced acute encephalopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K03174  TRAF3; TNF receptor-associated factor 3
   04668 TNF signaling pathway
    K03174  TRAF3; TNF receptor-associated factor 3
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K03174  TRAF3; TNF receptor-associated factor 3
   04621 NOD-like receptor signaling pathway
    K03174  TRAF3; TNF receptor-associated factor 3
   04622 RIG-I-like receptor signaling pathway
    K03174  TRAF3; TNF receptor-associated factor 3
   04657 IL-17 signaling pathway
    K03174  TRAF3; TNF receptor-associated factor 3
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03174  TRAF3; TNF receptor-associated factor 3
   05203 Viral carcinogenesis
    K03174  TRAF3; TNF receptor-associated factor 3
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K03174  TRAF3; TNF receptor-associated factor 3
  09172 Infectious disease: viral
   05161 Hepatitis B
    K03174  TRAF3; TNF receptor-associated factor 3
   05160 Hepatitis C
    K03174  TRAF3; TNF receptor-associated factor 3
   05171 Coronavirus disease - COVID-19
    K03174  TRAF3; TNF receptor-associated factor 3
   05164 Influenza A
    K03174  TRAF3; TNF receptor-associated factor 3
   05162 Measles
    K03174  TRAF3; TNF receptor-associated factor 3
   05168 Herpes simplex virus 1 infection
    K03174  TRAF3; TNF receptor-associated factor 3
   05167 Kaposi sarcoma-associated herpesvirus infection
    K03174  TRAF3; TNF receptor-associated factor 3
   05169 Epstein-Barr virus infection
    K03174  TRAF3; TNF receptor-associated factor 3
   05165 Human papillomavirus infection
    K03174  TRAF3; TNF receptor-associated factor 3
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K03174  TRAF3; TNF receptor-associated factor 3
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K03174  TRAF3; TNF receptor-associated factor 3
Genes
HSA: 7187(TRAF3)
PTR: 453178(TRAF3)
PPS: 100980798(TRAF3)
GGO: 101136595(TRAF3)
PON: 100460079(TRAF3)
PPYG: 129013033(TRAF3)
NLE: 100606382(TRAF3)
HMH: 116485188(TRAF3)
SSYN: 129487417(TRAF3)
MCC: 693961(TRAF3)
MCF: 102141355(TRAF3)
MTHB: 126959960
MNI: 105467377(TRAF3)
CSAB: 103229744(TRAF3)
CATY: 105596732(TRAF3)
PANU: 101015482(TRAF3)
TGE: 112629252(TRAF3)
MLEU: 105547858(TRAF3)
RRO: 104654431(TRAF3)
RBB: 108514953(TRAF3)
TFN: 117071333(TRAF3)
PTEH: 111538162(TRAF3)
CANG: 105518439(TRAF3)
CJC: 100387401(TRAF3)
SBQ: 101043245(TRAF3)
CIMI: 108304024(TRAF3)
ANAN: 105730166(TRAF3)
CSYR: 103250762(TRAF3)
MMUR: 105859313 105861087(TRAF3)
LCAT: 123644162(TRAF3)
PCOQ: 105812625(TRAF3)
OGA: 100947925(TRAF3)
MMU: 22031(Traf3)
MCAL: 110306954(Traf3)
MPAH: 110324559(Traf3)
RNO: 362788(Traf3)
MCOC: 116080944(Traf3)
ANU: 117697234(Traf3)
MUN: 110553240(Traf3)
CGE: 100756323(Traf3)
MAUA: 101831388(Traf3)
PROB: 127231159(Traf3)
PLEU: 114697589 114703073(Traf3)
MORG: 121434311(Traf3)
MFOT: 126509072
AAMP: 119818887(Traf3)
NGI: 103727622(Traf3)
HGL: 101718736(Traf3)
CPOC: 100734492(Traf3)
CCAN: 109688807(Traf3)
DORD: 105983154(Traf3)
DSP: 122122592(Traf3)
PLOP: 125363299(Traf3)
NCAR: 124976672
MMMA: 107150805(Traf3)
OCU: 100359083
OPI: 101522714(TRAF3)
TUP: 102471499(TRAF3)
GVR: 103609553(TRAF3)
CFA: 490867(TRAF3)
CLUD: 112656934(TRAF3)
VVP: 112930285(TRAF3)
VLG: 121493392(TRAF3)
NPO: 129496135(TRAF3)
AML: 100466406(TRAF3)
UMR: 103656774(TRAF3)
UAH: 113267235(TRAF3)
UAR: 123779266(TRAF3)
ELK: 111148495
LLV: 125103668
MPUF: 101671223(TRAF3)
MNP: 132000278(TRAF3)
MLK: 131837014(TRAF3)
NVS: 122894215(TRAF3)
ORO: 101374855(TRAF3)
EJU: 114206264(TRAF3)
ZCA: 113908816(TRAF3)
MLX: 118002595(TRAF3)
NSU: 110571685(TRAF3)
FCA: 101096739(TRAF3)
PYU: 121032321(TRAF3)
PCOO: 112855336(TRAF3)
PBG: 122469573(TRAF3)
PVIV: 125167483(TRAF3)
LRUF: 124512500
PTG: 102952767(TRAF3)
PPAD: 109274594
PUC: 125909139
AJU: 106975974
HHV: 120244583(TRAF3)
BTA: 506182(TRAF3)
BOM: 102276392(TRAF3)
BIU: 109575564(TRAF3)
BBUB: 102402262(TRAF3)
BBIS: 104996935(TRAF3)
CHX: 102171742(TRAF3)
OAS: 100036758(TRAF3)
BTAX: 128051762 128066664(TRAF3)
ODA: 120875162(TRAF3)
CCAD: 122454978(TRAF3)
MBEZ: 129550678(TRAF3)
SSC: 100156979(TRAF3)
CFR: 102515034(TRAF3)
CBAI: 105079948(TRAF3)
CDK: 105103454(TRAF3)
VPC: 102529156(TRAF3)
BACU: 102997874(TRAF3)
BMUS: 118890316(TRAF3)
LVE: 103084510(TRAF3)
OOR: 101288184(TRAF3)
DLE: 111176049(TRAF3)
PCAD: 102974816(TRAF3)
PSIU: 116748433(TRAF3)
NASI: 112408757(TRAF3)
ECB: 100055110(TRAF3)
EPZ: 103563515(TRAF3)
EAI: 106839629(TRAF3)
MYB: 102260783(TRAF3)
MYD: 102771530(TRAF3)
MMYO: 118655021(TRAF3)
MLF: 102420724(TRAF3)
MDT: 132228750(TRAF3)
PKL: 118714100(TRAF3)
EFUS: 103301807(TRAF3)
MNA: 107538601(TRAF3)
DRO: 112311693(TRAF3)
SHON: 118976597(TRAF3)
AJM: 119037870(TRAF3)
PDIC: 114492329(TRAF3)
PHAS: 123808159(TRAF3)
MMF: 118633499(TRAF3)
PPAM: 129066167(TRAF3)
HAI: 109381072(TRAF3)
RFQ: 117023550(TRAF3)
PALE: 102881091(TRAF3)
PGIG: 120619723(TRAF3)
PVP: 105299274(TRAF3)
RAY: 107521368(TRAF3)
MJV: 108406584(TRAF3)
TOD: 119239469(TRAF3) 119250785
SARA: 101538970(TRAF3)
SETR: 126033344(TRAF3)
LAV: 100668716(TRAF3)
TMU: 101347503
ETF: 101663779(TRAF3)
DNM: 101437632(TRAF3)
MDO: 100017361(TRAF3)
GAS: 123233879(TRAF3)
SHR: 100926344(TRAF3)
AFZ: 127549887
PCW: 110197337(TRAF3)
TVP: 118843066(TRAF3)
OAA: 100075919(TRAF3)
GGA: 423471(TRAF3)
PCOC: 116228830(TRAF3)
MGP: 100549776(TRAF3)
CJO: 107315348(TRAF3)
TPAI: 128085742(TRAF3)
LMUT: 125694526(TRAF3)
NMEL: 110401083(TRAF3)
APLA: 101796752(TRAF3)
ACYG: 106046989(TRAF3)
CATA: 118250240(TRAF3)
AFUL: 116489623(TRAF3)
TGU: 100218184(TRAF3)
LSR: 110476432(TRAF3)
SCAN: 103826414(TRAF3)
PMOA: 120503731(TRAF3)
OTC: 121331801(TRAF3)
PRUF: 121358229(TRAF3)
GFR: 102033090(TRAF3)
FAB: 101807381(TRAF3)
OMA: 130254031(TRAF3)
PHI: 102110443(TRAF3)
PMAJ: 107206012(TRAF3)
CCAE: 111929794(TRAF3)
CCW: 104686673(TRAF3)
CBRC: 103612168(TRAF3)
ETL: 114062306(TRAF3)
ZAB: 102062693(TRAF3)
ZLE: 135448089(TRAF3)
ACHL: 103798530(TRAF3)
SVG: 106850535(TRAF3)
MMEA: 130573359(TRAF3)
HRT: 120753830(TRAF3)
SATI: 136362851(TRAF3)
FPG: 101918364(TRAF3)
FCH: 102057349(TRAF3)
CCRI: 104163183
NNT: 104408547(TRAF3)
SHAB: 115606790(TRAF3)
ACUN: 113480589(TRAF3)
TALA: 104364460(TRAF3)
ACHC: 115352265(TRAF3)
HALD: 104322048(TRAF3)
HLE: 104841931(TRAF3)
AGEN: 126050490
GCL: 127016708
CSTI: 104559227(TRAF3)
LDI: 104340309
MNB: 103776314(TRAF3)
DPUB: 104304250(TRAF3)
AVIT: 104277536(TRAF3)
BRHI: 104493585(TRAF3)
EGZ: 104124519(TRAF3)
NNI: 104014514(TRAF3)
PCRI: 104028508
PCAO: 104044683(TRAF3)
PADL: 103920268(TRAF3)
AFOR: 103900217(TRAF3)
FGA: 104078892(TRAF3)
GSTE: 104258337
CLV: 102085500(TRAF3)
MUI: 104537198(TRAF3)
PGUU: 104470835(TRAF3)
PLET: 104614563(TRAF3)
EHS: 104510698(TRAF3)
CMAC: 104476939(TRAF3)
CUCA: 104057729(TRAF3)
TEO: 104374816(TRAF3)
BREG: 104642394(TRAF3)
OHA: 104331522(TRAF3)
ACAR: 104527415(TRAF3)
CPEA: 104390626(TRAF3)
CVF: 104291770(TRAF3)
RTD: 128908585(TRAF3)
AAM: 106482974(TRAF3)
AROW: 112972701(TRAF3)
NPD: 112955397(TRAF3)
TGT: 104577073(TRAF3)
DNE: 112989906(TRAF3)
SCAM: 104144466(TRAF3)
ASN: 102382120(TRAF3)
AMJ: 102566882(TRAF3)
CPOO: 109321776(TRAF3)
GGN: 109298436(TRAF3)
PSS: 102461304(TRAF3)
CMY: 102941336(TRAF3)
CCAY: 125638326(TRAF3)
DCC: 119857747(TRAF3)
CPIC: 101934942(TRAF3)
TST: 117876131(TRAF3)
CABI: 116819654(TRAF3) 116822854
MRV: 120404354(TRAF3)
ACS: 100555350(traf3)
ASAO: 132762146(TRAF3)
PVT: 110078930(TRAF3)
SUND: 121927129(TRAF3)
PBI: 103062211(TRAF3)
PMUR: 107287185(TRAF3)
CTIG: 120317862(TRAF3)
TSR: 106540064(TRAF3)
PGUT: 117666012(TRAF3)
APRI: 131187938(TRAF3)
PTEX: 113435020(TRAF3)
NSS: 113420338(TRAF3)
VKO: 123026415(TRAF3)
PMUA: 114583728(TRAF3)
PRAF: 128403620(TRAF3)
ZVI: 118080386(TRAF3)
HCG: 128330317(TRAF3)
GJA: 107116596(TRAF3)
STOW: 125426382(TRAF3)
EMC: 129324633(TRAF3)
XLA: 108698786(traf3.L) 108699773(traf3.S)
XTR: 100498216(traf3)
NPR: 108790750(TRAF3)
RTEM: 120920906(TRAF3)
BBUF: 120982059(TRAF3)
BGAR: 122922026(TRAF3) 122922119
MUO: 115477870(TRAF3)
GSH: 117364101(TRAF3)
DRE: 445119(traf3)
CCAR: 109051440
PTET: 122361489(traf3)
LROH: 127180150(traf3)
OMC: 131522734(traf3)
PPRM: 120477631(traf3)
RKG: 130069886(traf3)
MAMB: 125268882(traf3)
CIDE: 127499039
CERY: 137006239(traf3)
TROS: 130560364(traf3)
TDW: 130436682(traf3)
MANU: 129417261(traf3)
IPU: 108270346
IFU: 128612897(traf3)
PHYP: 113529545(traf3)
SMEO: 124390278(traf3)
TFD: 113659586(traf3)
TVC: 132852789(traf3)
TRN: 134324995(traf3)
AMEX: 103023640(traf3)
CMAO: 118823830(traf3)
EEE: 113571406(traf3)
CHAR: 105905076(traf3)
TRU: 101069888(traf3)
TFS: 130540332(traf3)
LCO: 104936575(traf3)
TBEN: 117481345(traf3)
GACU: 117541281(traf3)
EMAC: 134863192(traf3)
ELY: 117267267(traf3)
EFO: 125900775(traf3)
PLEP: 121966080
SLUC: 116065150(traf3)
ECRA: 117940992
PFLV: 114546663(traf3)
GAT: 120832813(traf3)
PPUG: 119227245(traf3)
AFB: 129103095(traf3)
CLUM: 117751250(traf3)
PSWI: 130201334(traf3)
SCHU: 122861810(traf3)
CUD: 121526124(traf3)
ALAT: 119004867(traf3)
MZE: 101485974(traf3)
ONL: 100702578(traf3)
OAU: 116327980(traf3)
OLA: 101161601(traf3)
OML: 112141746(traf3)
CSAI: 133462914(traf3)
XMA: 102234631(traf3)
XCO: 114156371(traf3)
XHE: 116709290(traf3)
PRET: 103458120(traf3)
PFOR: 103153848(traf3)
PLAI: 106964477(traf3)
PMEI: 106933555(traf3)
GAF: 122846061(traf3)
PPRL: 129377262(traf3)
CVG: 107084838(traf3)
CTUL: 119793673(traf3)
GMU: 124855223(traf3)
NFU: 107391834(traf3)
KMR: 108229307
ALIM: 106527291(traf3)
NWH: 119427220(traf3)
AOCE: 111576450(traf3)
MCEP: 125023691(traf3)
CSEM: 103382287(traf3)
POV: 109642230(traf3)
SSEN: 122783372(traf3)
HHIP: 117755976(traf3)
HSP: 118116317(traf3)
PPLT: 128451556(traf3)
SMAU: 118286069(traf3)
LCF: 108891610
SDU: 111236089(traf3)
SLAL: 111659505(traf3)
XGL: 120795368(traf3)
HCQ: 109520525(traf3)
SSCV: 125981169
SBIA: 133513139(traf3)
PEE: 133413268(traf3)
PTAO: 133487956(traf3)
BPEC: 110170878(traf3)
MALB: 109972474(traf3)
BSPL: 114848462(traf3)
SJO: 128375575(traf3)
SASA: 106600975 106611198(traf3)
OTW: 112244941(traf3) 112256827
OGO: 124001950(traf3) 124046622
SNH: 120023505 120059926(traf3)
ELS: 105023593(traf3)
SFM: 108919645(traf3)
PKI: 111843185
AANG: 118214249(traf3)
LOC: 102685862(traf3)
PSEX: 120518283(traf3)
LCM: 102358156 102362986(TRAF3)
CMK: 103175325(traf3)
RTP: 109915375(traf3)
CPLA: 122542695 122553534(traf3)
HOC: 132817941(traf3) 132836696
LERI: 129700569(traf3) 129714099
LPIC: 129264539
APLC: 110975243
ARUN: 117291337
DPE: 6604640
DHE: 111594071
MDE: 101891629
LCQ: 111688274
BMOR: 100862758
BMAN: 114247049
MSEX: 115442461
BANY: 112055072
AAGE: 121726392
HAW: 110380325
TNL: 113499903
OFU: 114363345
ATRA: 106141579
GMW: 113514674
LGLY: 125235871
LSM: 121119339
VDE: 111249344
VJA: 111263367
DFR: 124493260
BGT: 106050982
HRF: 124127397
MCAF: 127698948
OBI: 106869200
OSN: 115221196
LJP: 135466906
LLON: 135485236
 » show all
Reference
  Authors
He L, Grammer AC, Wu X, Lipsky PE
  Title
TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation.
  Journal
J Biol Chem 279:55855-65 (2004)
DOI:10.1074/jbc.M407284200
Reference
PMID:7527023
  Authors
Hu HM, O'Rourke K, Boguski MS, Dixit VM
  Title
A novel RING finger protein interacts with the cytoplasmic domain of CD40.
  Journal
J Biol Chem 269:30069-72 (1994)
  Sequence
[hsa:7187]

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