KEGG   ORTHOLOGY: K03176
Entry
K03176                      KO                                     

Name
NTRK1, TRKA
Definition
neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04722  Neurotrophin signaling pathway
ko04750  Inflammatory mediator regulation of TRP channels
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05216  Thyroid cancer
ko05230  Central carbon metabolism in cancer
Disease
H00032  Thyroid cancer
H00043  Neuroblastoma
H00265  Hereditary sensory and autonomic neuropathy
H01836  Congenital pain insensitivity with anhidrosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   04014 Ras signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   04151 PI3K-Akt signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
 09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   05202 Transcriptional misregulation in cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   05230 Central carbon metabolism in cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
  09162 Cancer: specific types
   05216 Thyroid cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  TRK family [OT]
   K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
Genes
HSA: 4914(NTRK1)
PTR: 457408(NTRK1)
PPS: 100995426(NTRK1)
GGO: 101125993(NTRK1)
PON: 100452269(NTRK1)
NLE: 100585466(NTRK1)
MCC: 719670(NTRK1)
MCF: 102129364(NTRK1)
CSAB: 103223823(NTRK1)
RRO: 104676442(NTRK1)
RBB: 108515538(NTRK1)
CJC: 103789024(NTRK1)
SBQ: 101035626(NTRK1)
MMU: 18211(Ntrk1)
MCAL: 110290875(Ntrk1)
MPAH: 110319787(Ntrk1)
RNO: 59109(Ntrk1)
MUN: 110564977(Ntrk1)
CGE: 100751271(Ntrk1)
NGI: 103750263(Ntrk1)
HGL: 101724441(Ntrk1)
CCAN: 109686202(Ntrk1)
OCU: 100354292(NTRK1)
TUP: 102485200(NTRK1)
CFA: 490404(NTRK1)
VVP: 112918800(NTRK1)
UAH: 113245211(NTRK1)
ORO: 101374117(NTRK1)
ELK: 111138872
FCA: 101081603(NTRK1)
PPAD: 109256209(NTRK1)
AJU: 106988854(NTRK1)
BTA: 353111(NTRK1)
BOM: 102264869(NTRK1)
BIU: 109556725(NTRK1)
BBUB: 102402551(NTRK1)
CHX: 102172584(NTRK1)
OAS: 101109763(NTRK1)
SSC: 100154471(NTRK1)
CFR: 102518397(NTRK1)
CDK: 105105672(NTRK1)
BACU: 103003654(NTRK1)
LVE: 103071756(NTRK1)
OOR: 101273503(NTRK1)
DLE: 111167102(NTRK1)
PCAD: 102990275(NTRK1)
ECB: 100064594(NTRK1)
EPZ: 103548862(NTRK1)
EAI: 106828447(NTRK1)
MYD: 102765751(NTRK1)
MNA: 107543738(NTRK1)
HAI: 109393379(NTRK1)
DRO: 112315668(NTRK1)
PALE: 112472150(NTRK1)
RAY: 107521477(NTRK1)
MJV: 108383338(NTRK1)
LAV: 100668650(NTRK1)
TMU: 101351378
MDO: 100618744(NTRK1)
SHR: 100916388(NTRK1)
PCW: 110212119(NTRK1)
OAA: 103167743(NTRK1)
GGA: 396337(NTRK1)
MGP: 100541244(NTRK1)
CJO: 107324385(NTRK1)
NMEL: 110388022(NTRK1)
TGU: 115498457(NTRK1)
LSR: 110471556(NTRK1)
SCAN: 103824820(NTRK1)
GFR: 102039729(NTRK1)
FAB: 101810326(NTRK1)
PHI: 102113646(NTRK1)
PMAJ: 107214529(NTRK1)
CCAE: 111939539
CCW: 104683563(NTRK1)
ETL: 114071558(NTRK1)
FPG: 101920297(NTRK1)
FCH: 102060232(NTRK1)
CLV: 102086876(NTRK1)
NNI: 104015011(NTRK1)
AAM: 106495087(NTRK1)
ASN: 102381668(NTRK1)
AMJ: 102568424(NTRK1)
PSS: 102456174(NTRK1)
CMY: 102940175(NTRK1)
CPIC: 101934097(NTRK1)
ACS: 100556611(ntrk1)
PVT: 110081467(NTRK1)
PBI: 103064232(NTRK1)
PMUR: 107298512(NTRK1)
TSR: 106540381
PMUA: 114586656(NTRK1)
GJA: 107114884(NTRK1)
XTR: 100489637(ntrk1)
NPR: 108802180(NTRK1)
DRE: 30546(ntrk1)
SRX: 107726660(ntrk1) 107728446
IPU: 108256584(ntrk1)
PHYP: 113532627(ntrk1)
AMEX: 103025260(ntrk1)
EEE: 113571898(ntrk1)
TRU: 101074407(ntrk1)
LCO: 104933369(ntrk1)
NCC: 104949794(ntrk1)
MZE: 101473195(ntrk1)
ONL: 100699013(ntrk1)
OLA: 101164184(ntrk1)
XMA: 102217423
XCO: 114141649(ntrk1)
PRET: 103477579(ntrk1)
CVG: 107101837(ntrk1)
NFU: 107379148(ntrk1)
KMR: 108246005(ntrk1)
ALIM: 106528305(ntrk1)
AOCE: 111579099(ntrk1)
CSEM: 103388944(ntrk1)
POV: 109642014(ntrk1)
LCF: 108899467(ntrk1)
SDU: 111222591(ntrk1)
SLAL: 111655673(ntrk1)
HCQ: 109512189(ntrk1)
BPEC: 110172749
MALB: 109965566(ntrk1)
ELS: 105019278(ntrk1)
SFM: 108926773(ntrk1) 108930374
LCM: 102354132(NTRK1)
AME: 725720
BIM: 100746731
BTER: 100645995
CCAL: 108631595
SOC: 105208070
MPHA: 105837008
AEC: 105142993
ACEP: 105627688
HST: 105184311
CFO: 105252670
LHU: 105678901
CSOL: 105359701
AGS: 114133003
 » show all
Reference
  Authors
Tacconelli A, Farina AR, Cappabianca L, Desantis G, Tessitore A, Vetuschi A, Sferra R, Rucci N, Argenti B, Screpanti I, Gulino A, Mackay AR
  Title
TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma.
  Journal
Cancer Cell 6:347-60 (2004)
DOI:10.1016/j.ccr.2004.09.011
  Sequence
[hsa:4914]

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