KEGG ORTHOLOGY: K03176

ORTHOLOGY: K03176

Entry

K03176                      KO

Symbol

NTRK1, TRKA

Name

neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]

Pathway

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04020

Calcium signaling pathway

map04151

PI3K-Akt signaling pathway

map04210

Apoptosis

map04722

Neurotrophin signaling pathway

map04750

Inflammatory mediator regulation of TRP channels

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05216

Thyroid cancer

map05230

Central carbon metabolism in cancer

Disease

H00032

Thyroid cancer

H00043

Neuroblastoma

H00265

Hereditary sensory and autonomic neuropathy

H01836

Congenital pain insensitivity with anhidrosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   04014 Ras signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   04020 Calcium signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   04151 PI3K-Akt signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   05202 Transcriptional misregulation in cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   05230 Central carbon metabolism in cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
  09162 Cancer: specific types
   05216 Thyroid cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
Protein kinases [BR:ko01001]
Receptor tyrosine kinases (RTK)
  TRK family [OT]
   K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1

Genes

HSA:	4914(NTRK1)

PTR:	457408(NTRK1)

PPS:	129397852(NTRK1)

GGO:	101125993(NTRK1)

PON:	100452269(NTRK1)

PPYG:

129006198(NTRK1)

NLE:	100585466(NTRK1)

HMH:	116467918(NTRK1)

SSYN:

134734430(NTRK1)

MCC:	719670(NTRK1)

MCF:	102129364(NTRK1)

MTHB:

126948042

MNI:	105498076(NTRK1)

CSAB:

103223823(NTRK1)

CATY:

105594539(NTRK1)

PANU:

101012772(NTRK1)

TGE:	112607006(NTRK1)

MLEU:

105548667(NTRK1)

RRO:	104676442(NTRK1)

RBB:	108515538(NTRK1)

TFN:	117076785(NTRK1)

PTEH:

111543817(NTRK1)

CANG:

105502088(NTRK1)

CJC:	103789024(NTRK1)

SBQ:	101035626(NTRK1)

CIMI:

108290257(NTRK1)

ANAN:

105715426(NTRK1)

CSYR:

103251204(NTRK1)

MMUR:

105873105(NTRK1)

LCAT:

123634790(NTRK1) 123634791

PCOQ:

105821881(NTRK1)

OGA:	100940422(NTRK1)

MMU:	18211(Ntrk1)

MCAL:

110290875(Ntrk1)

MPAH:

110319787(Ntrk1)

RNO:	59109(Ntrk1)

MCOC:

116093096 116094433

ANU:	117707235(Ntrk1)

MUN:	110564977(Ntrk1)

CGE:	100751271(Ntrk1)

MAUA:

101843619(Ntrk1)

PROB:

127232683(Ntrk1)

PLEU:

114683361(Ntrk1)

MORG:

121450738(Ntrk1)

MFOT:

126486514

AAMP:

119800869(Ntrk1)

NGI:	103750263(Ntrk1)

HGL:	101724441(Ntrk1)

CPOC:

100725325(Ntrk1)

CCAN:

109686202(Ntrk1)

DORD:

105996438(Ntrk1)

DSP:	122109658(Ntrk1)

PLOP:

125360177(Ntrk1)

NCAR:

124985938

MMMA:

107156672(Ntrk1)

OCU:

100354292

OPI:	101528482(NTRK1)

TUP:	102485200(NTRK1)

GVR:	103588563(NTRK1)

CFA:	490404(NTRK1)

CLUD:

112648872(NTRK1)

VVP:	112918800(NTRK1)

VLG:	121484071(NTRK1)

NPO:	129509029(NTRK1)

UAH:	113245211(NTRK1)

UAR:	123783398(NTRK1)

ELK:

111138872

LLV:

125085737

MPUF:

101684239(NTRK1)

MNP:	132025841(NTRK1)

MLK:	131814908(NTRK1)

NVS:	122918316(NTRK1)

ORO:	101374117(NTRK1)

EJU:	114198649(NTRK1)

ZCA:	113932722(NTRK1)

MLX:	118013921(NTRK1)

NSU:	110573455 123323631

LWW:	102727057(NTRK1)

FCA:	101081603(NTRK1)

PYU:	121015457(NTRK1)

PBG:	122475682(NTRK1)

PVIV:

125155826(NTRK1)

LRUF:

124521817

PPAD:

109256209(NTRK1)

PUC:

125925658

AJU:

106988854

HHV:	120244665(NTRK1)

BTA:	353111(NTRK1)

BOM:	102264869(NTRK1)

BIU:	109556725(NTRK1)

BBUB:

102402551(NTRK1)

BBIS:

104987347(NTRK1)

CHX:	102172584(NTRK1)

OAS:	101109763(NTRK1)

BTAX:

128044483(NTRK1)

ODA:	120855667(NTRK1)

CCAD:

122431869(NTRK1)

MBEZ:

129540753(NTRK1)

SSC:	100154471(NTRK1)

CFR:	102518397(NTRK1)

CBAI:

105068230(NTRK1)

CDK:	105105672(NTRK1)

VPC:	102543920(NTRK1)

BACU:

103003654(NTRK1)

BMUS:

118886471(NTRK1)

LVE:	103071756(NTRK1)

OOR:	101273503(NTRK1)

DLE:	111167102(NTRK1)

PCAD:

102990275(NTRK1)

PSIU:

116756746(NTRK1)

NASI:

112401754(NTRK1)

ECB:	100064594(NTRK1)

EPZ:	103548862(NTRK1)

EAI:	106828447(NTRK1)

MYD:	102765751(NTRK1)

MMYO:

118673526(NTRK1)

MLF:	102431497(NTRK1)

MDT:	132220304(NTRK1)

PKL:	118721515(NTRK1)

EFUS:

103298850(NTRK1)

MNA:	107543738(NTRK1)

DRO:	112315668(NTRK1)

AJM:	119039739(NTRK1)

PDIC:

114489015(NTRK1)

PHAS:

123804735(NTRK1)

MMF:	118637108(NTRK1)

PPAM:

129062360(NTRK1)

HAI:	109393379(NTRK1)

RFQ:	117014296(NTRK1)

PALE:

112472150(NTRK1)

PGIG:

120606120(NTRK1)

PVP:	105296416(NTRK1)

RAY:	107521477(NTRK1)

MJV:	108383338(NTRK1)

TOD:	119236305(NTRK1)

SARA:

101540859(NTRK1)

SETR:

126020472(NTRK1)

LAV:	100668650(NTRK1)

TMU:

101351378

ETF:	101647167(NTRK1)

DNM:	101425856(NTRK1)

MDO:	100618744(NTRK1)

GAS:	123246086(NTRK1)

SHR:	100916388(NTRK1)

AFZ:

127559757

PCW:	110212119(NTRK1)

TVP:	118846231(NTRK1)

OAA:

103167743

GGA:	396337(NTRK1)

PCOC:

116237273(NTRK1)

MGP:	100541244(NTRK1)

CJO:	107324385(NTRK1)

TPAI:

128090579(NTRK1)

LMUT:

125685910(NTRK1)

NMEL:

110388022(NTRK1)

ACYG:

136788151(NTRK1)

CATA:

118258616(NTRK1)

AFUL:

116499797(NTRK1)

TGU:	115498457(NTRK1)

LSR:	110471556(NTRK1)

SCAN:

103824820(NTRK1)

PMOA:

120498961(NTRK1)

OTC:	121332151(NTRK1)

PRUF:

121352173(NTRK1)

GFR:	102039729(NTRK1)

FAB:	101810326(NTRK1)

OMA:	130262596(NTRK1)

PHI:	102113646(NTRK1)

PMAJ:

107214529(NTRK1)

CCAE:

111939539

CBRC:

103611288(NTRK1)

ETL:	114071558(NTRK1)

ZAB:	113460658(NTRK1)

ZLE:	135457899(NTRK1)

SVG:	106861108(NTRK1)

MMEA:

130584674(NTRK1)

SATI:

136372874(NTRK1)

FPG:	101920297(NTRK1)

FCH:	102060232(NTRK1)

SHAB:

115602793(NTRK1)

TALA:

116965970(NTRK1)

ACHC:

115345406(NTRK1)

HLE:	104829748(NTRK1)

AGEN:

126040546

GCL:

127026894

CSTI:

104556722(NTRK1)

NNI:	104015011(NTRK1)

AFOR:

103899693

CLV:	102086876(NTRK1)

CUCA:

104057097(NTRK1)

RTD:	128900916(NTRK1)

AAM:	106495087(NTRK1)

AROW:

112969974(NTRK1)

NPD:	112953544(NTRK1)

DNE:	112990827(NTRK1)

ASN:	102381668(NTRK1)

AMJ:	102568424(NTRK1)

CPOO:

109324023(NTRK1)

GGN:	109298723(NTRK1)

PSS:	102456174(NTRK1)

CMY:	102940175(NTRK1)

CCAY:

125625777(NTRK1)

DCC:	119847779(NTRK1)

CPIC:

101934097(NTRK1)

TST:	117869852(NTRK1)

CABI:

116831884(NTRK1)

MRV:	120390665(NTRK1)

ACS:	100556611(ntrk1)

ASAO:

132764609(NTRK1)

PVT:	110081467(NTRK1)

SUND:

121916146(NTRK1)

PBI:	103064232(NTRK1)

PMUR:

107298512(NTRK1)

TSR:

106540381

PGUT:

117670110(NTRK1)

APRI:

131186552(NTRK1)

PTEX:

113449167(NTRK1)

NSS:	113424285(NTRK1)

PMUA:

114586656(NTRK1)

PRAF:

128403853(NTRK1)

ZVI:	118094598(NTRK1)

HCG:	128337719(NTRK1)

GJA:	107114884(NTRK1)

STOW:

125436340

EMC:	129343303(NTRK1)

XLA:	108699388(ntrk1.L) 108700358(ntrk1.S)

XTR:	100489637(ntrk1)

NPR:	108802180(NTRK1)

RTEM:

120920783(NTRK1)

BBUF:

120981563(NTRK1)

BGAR:

122921449(NTRK1)

MUO:	115458339(NTRK1)

GSH:	117349556(NTRK1)

DRE:	30546(ntrk1)

SRX:	107726660(ntrk1) 107728446

SANH:

107671431 107688245

SGH:	107592146 107592455

CCAR:

109105038 109106243

CAUA:

113059262 113115732

CGIB:

127974828 128031192

PTET:

122360017(ntrk1) 122360019

LROH:

127178297(ntrk1)

OMC:	131521577(ntrk1)

PPRM:

120488019(ntrk1)

RKG:	130077673(ntrk1)

MAMB:

125242834(ntrk1)

CIDE:

127497004

CERY:

137028123(ntrk1)

MASI:

127453110 127453586

TROS:

130557490(ntrk1)

TDW:	130432440(ntrk1)

MANU:

129448654(ntrk1)

IPU:

108256584

IFU:	128599510(ntrk1)

PHYP:

113532627(ntrk1)

SMEO:

124403851(ntrk1)

TFD:	113649760(ntrk1)

TVC:	132839973(ntrk1)

TRN:	134300759(ntrk1)

AMEX:

103025260(ntrk1)

CMAO:

118798677(ntrk1)

EEE:	113571898(ntrk1)

CHAR:

105891941(ntrk1)

TRU:	101074407(ntrk1)

TFS:	130532640(ntrk1)

TNG:	GSTEN00019520G001

LCO:	104933369(ntrk1)

NCC:	104949794(ntrk1)

TBEN:

117468490(ntrk1)

CGOB:

115021582(ntrk1)

PGEO:

117461351(ntrk1)

GACU:

117543250(ntrk1)

EMAC:

134861899(ntrk1)

ELY:	117265685(ntrk1)

EFO:	125892733(ntrk1)

PLEP:

121945177(ntrk1)

SLUC:

116036003(ntrk1)

ECRA:

117945668(ntrk1)

ESP:	116691144(ntrk1)

PFLV:

114557434(ntrk1)

GAT:	120810204(ntrk1)

PPUG:

119197939(ntrk1)

AFB:	129109152(ntrk1)

CLUM:

117728257(ntrk1)

PSWI:

130213198(ntrk1)

MSAM:

119897108(ntrk1)

SCHU:

122881515(ntrk1)

CUD:	121513058(ntrk1)

ALAT:

119005315(ntrk1)

MZE:	101473195(ntrk1)

ONL:	100699013(ntrk1)

OAU:	116315384(ntrk1)

OLA:	101164184(ntrk1)

OML:	112136520(ntrk1)

CSAI:

133438997(ntrk1)

XMA:

102217423

XCO:	114141649(ntrk1)

XHE:

116716954

PRET:

103477579(ntrk1)

PFOR:

103150831

PLAI:

106954407

PMEI:

106919456

GAF:	122830607(ntrk1)

PPRL:

129370914(ntrk1)

CVG:	107101837(ntrk1)

CTUL:

119796673(ntrk1)

GMU:	124865367(ntrk1)

NFU:	107379148(ntrk1)

KMR:	108246005(ntrk1)

ALIM:

106528305(ntrk1)

NWH:	119409238(ntrk1)

AOCE:

111579099(ntrk1)

MCEP:

125015712(ntrk1)

CSEM:

103388944(ntrk1)

POV:	109642014(ntrk1)

SSEN:

122775185(ntrk1)

HHIP:

117776253(ntrk1)

HSP:	118113983(ntrk1)

PPLT:

128449727(ntrk1)

SMAU:

118285185(ntrk1)

LCF:

108899467

SDU:	111222591(ntrk1)

SLAL:

111655673(ntrk1)

XGL:	120784416(ntrk1)

HCQ:	109512189(ntrk1)

SSCV:

125975659

SBIA:

133500412(ntrk1)

PEE:	133401853(ntrk1)

PTAO:

133480037(ntrk1)

BPEC:

110172749

MALB:

109965566(ntrk1)

BSPL:

114842814(ntrk1)

SJO:	128366649(ntrk1)

SASA:

106581868 106605284

STRU:

115176899 115178403

OTW:	112222988(ntrk1) 112223654

OMY:	110487707(ntrk1) 110503966

OGO:	123997297 124005334

ONE:	115114168 115141105

OKI:	109901732 109908819

OKE:	118364403 118367456

SALP:

111959090 111965133

SNH:	120031620 120048389

CCLU:

121543083(ntrk1)

ELS:	105019278(ntrk1)

SFM:	108926773(ntrk1) 108930374

PKI:	111838441 111853509

AANG:

118234166(ntrk1)

LOC:	102683487(ntrk1)

PSPA:

121309852(ntrk1)

ARUT:

117395629 117970830

PSEX:

120517965(ntrk1)

LCM:	102354132(NTRK1)

LERI:

BBEL:

SOC:

MPHA:

AEC:

ACEP:

HST:

CFO:

FEX:

LHU:

CSOL:

FAS:

AGS:

PMOO:

CQD:

HAZT:

DSV:

RSAN:

RMP:

VDE:

VJA:	111268435 111273063

SDM:

BGT:

GAE:

Reference

PMID:15488758

Authors

Tacconelli A, Farina AR, Cappabianca L, Desantis G, Tessitore A, Vetuschi A, Sferra R, Rucci N, Argenti B, Screpanti I, Gulino A, Mackay AR

Title

TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma.

Journal

Cancer Cell 6:347-60 (2004)
DOI:10.1016/j.ccr.2004.09.011

Sequence

[hsa:4914]

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (22)   
   KEGG PATHWAY (22)   
Disease (4)   
   KEGG DISEASE (4)   
Drug (9)   
   KEGG DRUG (9)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (600)   
   KEGG GENES (403)   
   KEGG MGENES (120)   
   RefGene (71)   
   OC (6)   
Literature (1)   
   PubMed (1)   
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