KEGG ORTHOLOGY: K03209

ORTHOLOGY: K03209

Entry

K03209                      KO

Symbol

WNT1

Name

wingless-type MMTV integration site family, member 1

Pathway

map04150

mTOR signaling pathway

map04310

Wnt signaling pathway

map04390

Hippo signaling pathway

map04391

Hippo signaling pathway - fly

map04550

Signaling pathways regulating pluripotency of stem cells

map04916

Melanogenesis

map04934

Cushing syndrome

map05010

Alzheimer disease

map05022

Pathways of neurodegeneration - multiple diseases

map05165

Human papillomavirus infection

map05200

Pathways in cancer

map05205

Proteoglycans in cancer

map05207

Chemical carcinogenesis - receptor activation

map05217

Basal cell carcinoma

map05224

Breast cancer

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

Disease

H00506

Osteogenesis imperfecta

H01593

Osteoporosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K03209  WNT1; wingless-type MMTV integration site family, member 1
   04390 Hippo signaling pathway
    K03209  WNT1; wingless-type MMTV integration site family, member 1
   04391 Hippo signaling pathway - fly
    K03209  WNT1; wingless-type MMTV integration site family, member 1
   04150 mTOR signaling pathway
    K03209  WNT1; wingless-type MMTV integration site family, member 1
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K03209  WNT1; wingless-type MMTV integration site family, member 1
09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    K03209  WNT1; wingless-type MMTV integration site family, member 1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03209  WNT1; wingless-type MMTV integration site family, member 1
   05205 Proteoglycans in cancer
    K03209  WNT1; wingless-type MMTV integration site family, member 1
   05207 Chemical carcinogenesis - receptor activation
    K03209  WNT1; wingless-type MMTV integration site family, member 1
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K03209  WNT1; wingless-type MMTV integration site family, member 1
   05226 Gastric cancer
    K03209  WNT1; wingless-type MMTV integration site family, member 1
   05217 Basal cell carcinoma
    K03209  WNT1; wingless-type MMTV integration site family, member 1
   05224 Breast cancer
    K03209  WNT1; wingless-type MMTV integration site family, member 1
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K03209  WNT1; wingless-type MMTV integration site family, member 1
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K03209  WNT1; wingless-type MMTV integration site family, member 1
   05022 Pathways of neurodegeneration - multiple diseases
    K03209  WNT1; wingless-type MMTV integration site family, member 1
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K03209  WNT1; wingless-type MMTV integration site family, member 1
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins
    K03209  WNT1; wingless-type MMTV integration site family, member 1
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Morphogens
   K03209  WNT1; wingless-type MMTV integration site family, member 1

Other DBs

GO:

0005109

Genes

HSA:	7471(WNT1)

PTR:	742674(WNT1)

PPS:	100995465(WNT1)

GGO:	101143181(WNT1)

PON:	100441356(WNT1)

PPYG:

129009393(WNT1)

NLE:	100587307(WNT1)

HMH:	116462014(WNT1)

SSYN:

129491130(WNT1)

MCC:	709009(WNT1)

MCF:	102120871(WNT1)

MTHB:

126930178

MNI:	105492891(WNT1)

CSAB:

103238251(WNT1)

CATY:

105580466(WNT1)

PANU:

101013629(WNT1)

TGE:	112635320(WNT1)

MLEU:

105544955(WNT1)

RRO:	104679729(WNT1)

RBB:	108543922(WNT1)

TFN:	117090185(WNT1)

PTEH:

111542045(WNT1)

CANG:

105507640(WNT1)

CJC:	100389319(WNT1)

SBQ:	101044133(WNT1)

CIMI:

108316031(WNT1)

ANAN:

105709432(WNT1)

CSYR:

103273454(WNT1)

MMUR:

105869202(WNT1)

LCAT:

123640434(WNT1)

PCOQ:

105817598(WNT1)

OGA:	100943890(WNT1)

MMU:	22408(Wnt1)

MCAL:

110310964(Wnt1)

MPAH:

110335204(Wnt1)

RNO:	24881(Wnt1)

MCOC:

116082044(Wnt1)

ANU:	117719132(Wnt1)

MUN:	110547435(Wnt1)

CGE:	100766046(Wnt1)

MAUA:

101838833(Wnt1)

PROB:

127225589(Wnt1)

PLEU:

114708572(Wnt1)

MORG:

121441513(Wnt1)

MFOT:

126493761

AAMP:

119824043(Wnt1)

NGI:	103750567(Wnt1)

HGL:	101722636(Wnt1)

CPOC:

100717026(Wnt1)

CCAN:

109694825(Wnt1)

DORD:

105987495(Wnt1)

DSP:	122106358(Wnt1)

PLOP:

125354832(Wnt1)

NCAR:

124981913

MMMA:

107148723(Wnt1)

OCU:

100354018

OPI:	101526533(WNT1)

TUP:	102499190(WNT1)

GVR:	103588854(WNT1)

CFA:	486560(WNT1)

CLUD:

112678279(WNT1)

VVP:	112921098(WNT1)

VLG:	121480178(WNT1)

NPO:	129517408(WNT1)

AML:	100475007(WNT1)

UMR:	103675620(WNT1)

UAH:	113257365(WNT1)

UAR:	123794641(WNT1)

ELK:

111158015

LLV:

125107370

MPUF:

101672619(WNT1)

MNP:	132020688(WNT1)

MLK:	131837931(WNT1)

NVS:	122891308(WNT1)

ORO:	101370511(WNT1)

EJU:	114225695(WNT1)

ZCA:	113921956(WNT1)

MLX:	118008496(WNT1)

NSU:	110593633(WNT1)

LWW:	102730706(WNT1)

FCA:	101094190(WNT1)

PYU:	121038637(WNT1)

PCOO:

112867717(WNT1)

PBG:	122472345(WNT1)

PVIV:

125170971(WNT1)

LRUF:

124501222

PTG:	102962277(WNT1)

PPAD:

109249055(WNT1)

PUC:

125920405

AJU:

106969330

HHV:	120223020(WNT1)

BTA:	540662(WNT1)

BOM:	102268143(WNT1)

BIU:	109558697(WNT1)

BBUB:

102403747(WNT1)

BBIS:

105001685(WNT1)

CHX:	102180014(WNT1)

OAS:	101103389(WNT1)

BTAX:

128048884(WNT1)

ODA:	120858193 120861282

CCAD:

122427439(WNT1)

MBEZ:

129537207(WNT1)

SSC:	100525462(WNT1)

CFR:	102521780(WNT1)

CBAI:

105076195(WNT1)

CDK:	105103785(WNT1)

VPC:	102535386(WNT1)

BACU:

103017176(WNT1)

BMUS:

118902702(WNT1)

LVE:	103078640(WNT1)

OOR:	101270541(WNT1)

DLE:	111174055(WNT1)

PCAD:

102983530(WNT1)

PSIU:

116761039(WNT1)

NASI:

112394416(WNT1)

ECB:	100058859(WNT1)

EPZ:	103552200(WNT1)

EAI:	106836901(WNT1)

MYB:	102245856(WNT1)

MYD:	102764877(WNT1)

MMYO:

118650977(WNT1)

MLF:	102433775(WNT1)

MDT:	132226098(WNT1)

PKL:	118730320(WNT1)

EFUS:

103285257(WNT1)

MNA:	107528239(WNT1)

DRO:	112318261(WNT1)

SHON:

118976390(WNT1)

AJM:	119041907(WNT1)

PDIC:

114512643(WNT1)

PHAS:

123812722(WNT1)

MMF:	118624573(WNT1)

PPAM:

129084670(WNT1)

HAI:	109393219(WNT1)

RFQ:	117029017(WNT1)

PALE:

102888016(WNT1)

PGIG:

120618559(WNT1)

PVP:	105297529(WNT1)

RAY:	107514294(WNT1)

MJV:	108383443(WNT1)

TOD:	119248399(WNT1)

SARA:

101557092(WNT1)

SETR:

126022557(WNT1)

TMU:

101352160

ETF:	101648285(WNT1)

DNM:	101431125(WNT1)

MDO:	100032741(WNT1)

GAS:	123250610(WNT1)

SHR:	100928059(WNT1)

AFZ:

127537975

PCW:	110194136(WNT1)

TVP:	118849719(WNT1)

OAA:	114814562(WNT1)

GGA:	396160(WNT1)

PCOC:

116239277(WNT1)

MGP:

104916364

CJO:	107325739(WNT1)

APLA:

119715309(WNT1)

ACYG:

106047715(WNT1)

CATA:

118261353(WNT1)

AFUL:

116499975(WNT1)

TGU:	100229313(WNT1)

LSR:	110480394(WNT1)

SCAN:

103824623(WNT1)

PMOA:

120499490(WNT1)

OTC:	121334262(WNT1)

PRUF:

121356311(WNT1)

GFR:	102033698(WNT1)

FAB:	101817901(WNT1)

OMA:	130265755(WNT1)

PHI:	102103458(WNT1)

PMAJ:

107198589(WNT1)

CCAE:

111944514

CBRC:

103611915(WNT1)

ETL:	114071074(WNT1)

ZAB:	102069614(WNT1)

ZLE:	135459117(WNT1)

ACHL:

103808659(WNT1)

SVG:	106862662(WNT1)

MMEA:

130584148(WNT1)

HRT:	120764429(WNT1)

SATI:

136372812(WNT1)

FPG:	101915237(WNT1)

FCH:	102049459(WNT1)

SHAB:

115618657(WNT1)

TALA:

116962937(WNT1)

ACHC:

115351113(WNT1)

HLE:	104831178(WNT1)

AGEN:

126046375

AFOR:

103903433(WNT1)

CLV:	102091634(WNT1)

CMAC:

104486825(WNT1)

CUCA:

104055017(WNT1)

CVF:	104284816(WNT1)

RTD:	128901276(WNT1)

AAM:	106497501(WNT1)

NPD:	112950301(WNT1)

DNE:	112997344(WNT1)

ASN:	102372844(WNT1)

AMJ:	102559781(WNT1)

GGN:

109305432

PSS:	102450278(WNT1)

CMY:	102937737(WNT1)

CCAY:

125627482(WNT1)

DCC:	119845771(WNT1)

CPIC:

101933470(WNT1)

TST:	117888985(WNT1)

CABI:

116827701(WNT1)

MRV:	120391076(WNT1)

ACS:	100562340(wnt1)

ASAO:

132766599(WNT1)

PVT:	110075264(WNT1)

SUND:

121922742(WNT1)

PBI:	103053050(WNT1)

PMUR:

107287780(WNT1)

CTIG:

120302344(WNT1)

TSR:

106549320

PGUT:

117662747(WNT1)

APRI:

131191114(WNT1)

PTEX:

113445507(WNT1)

NSS:	113418484(WNT1)

VKO:	123019049(WNT1)

PMUA:

114592956(WNT1)

PRAF:

128405084(WNT1)

ZVI:	118081448(WNT1)

HCG:	128342223(WNT1)

GJA:	107120894(WNT1)

STOW:

125430301(WNT1)

EMC:	129328332(WNT1)

XLA:	108709815(wnt1.S) 373578(wnt1.L)

XTR:	100491444(wnt1)

NPR:	108791403(WNT1)

RTEM:

120928559(WNT1)

BBUF:

120993632(WNT1)

BGAR:

122932486(WNT1)

MUO:	115464883(WNT1)

GSH:	117357252(WNT1)

DRE:	30128(wnt1)

SRX:	107716204 107745472

SANH:

107681946 107695811

SGH:	107563635 107570486

CCAR:

109065063(wnt1)

CAUA:

113065489 113070546

CGIB:

127944157 128011233

PTET:

122328477(wnt1)

LROH:

127154336(wnt1)

OMC:	131531808(wnt1)

PPRM:

120463643(wnt1)

RKG:	130073465(wnt1)

MAMB:

125260827(wnt1)

CIDE:

127505530

CERY:

137008902(wnt1)

MASI:

127419190 127420606

TROS:

130544975(wnt1)

TDW:	130409287(wnt1)

MANU:

129431419(wnt1)

IPU:

108276209

IFU:	128619702(wnt1)

PHYP:

113530642(wnt1)

TFD:	113658271(wnt1)

TVC:	132862142(wnt1)

TRN:	134333256(wnt1)

AMEX:

103042266(wnt1)

CMAO:

118822965(wnt1)

EEE:	113584444(wnt1)

CHAR:

105897341(wnt1)

TRU:	101061628(wnt1)

TFS:	130530498(wnt1)

TNG:	GSTEN00003242G001 GSTEN00028074G001

LCO:	104932478(wnt1)

NCC:	104956879(wnt1)

TBEN:

117494442(wnt1)

CGOB:

115010646(wnt1)

PGEO:

117449702(wnt1)

GACU:

117541847(wnt1)

EMAC:

134868207(wnt1)

ELY:	117257693(wnt1)

EFO:	125891681(wnt1)

PLEP:

121946535(wnt1)

SLUC:

116038815(wnt1)

ECRA:

117947785(wnt1)

ESP:	116692258(wnt1)

PFLV:

114558141(wnt1)

GAT:	120829114(wnt1)

PPUG:

119205307(wnt1) 119206525

AFB:	129099406(wnt1)

CLUM:

117733495(wnt1)

PSWI:

130199685(wnt1)

MSAM:

119906206(wnt1)

SCHU:

122883020(wnt1)

CUD:	121517604(wnt1)

ALAT:

119022886(wnt1)

MZE:	101475965(wnt1)

ONL:	100710411(wnt1)

OAU:	116325869(wnt1)

OLA:	100125456(wnt1)

OML:	112159163(wnt1)

CSAI:

133456485(wnt1)

XMA:	102224929(wnt1)

XCO:	114148723(wnt1)

XHE:	116727312(wnt1)

PRET:

103467362(wnt1)

PFOR:

103141122(wnt1)

PLAI:

106955351(wnt1)

PMEI:

106921536(wnt1)

GAF:	122828579(wnt1)

PPRL:

129372570(wnt1)

CVG:	107091396(wnt1)

CTUL:

119785039(wnt1)

GMU:	124862920(wnt1)

NFU:	107390891(wnt1)

KMR:	108235196(wnt1)

ALIM:

106524809(wnt1)

NWH:	119416960(wnt1)

AOCE:

111581815(wnt1)

MCEP:

125011172(wnt1)

CSEM:

103385099(wnt1)

POV:	109630840(wnt1)

SSEN:

122776588(wnt1)

HHIP:

117764987(wnt1)

HSP:	118110464(wnt1)

PPLT:

128442614(wnt1)

SMAU:

118316371(wnt1)

LCF:

108876564

SDU:	111219027(wnt1)

SLAL:

111668938(wnt1)

XGL:	120804475(wnt1)

HCQ:	109531330(wnt1)

SSCV:

125988856

SBIA:

133493982(wnt1)

PEE:	133402444(wnt1)

PTAO:

133478397(wnt1)

BPEC:

110164735(wnt1)

MALB:

109969901(wnt1)

BSPL:

114858931(wnt1)

SJO:	128357061(wnt1)

SASA:

106567052 106572674

STRU:

115165508 115167848

OTW:	112221509(wnt1) 112247356

OMY:	110491973(wnt1) 110531239

OGO:	124032275 124045157(wnt1)

ONE:	115102564 115132866

OKI:	109868890 109878421

OKE:	118360105(wnt1) 118360379

SALP:

111966803 111976268

SNH:	120058823 120060632(wnt1)

CCLU:

121537401 121546749(wnt1)

ELS:	105013565(wnt1)

SFM:

108939183

PKI:	111854907 111860627

AANG:

118207482(wnt1)

LOC:	102694206(wnt1)

PSPA:

121307173(wnt1)

ARUT:

117401155 117967005

PSEX:

120525165(wnt1)

LCM:	102350033(WNT1)

CMK:	103189269(wnt1)

RTP:

109924630

CPLA:

122543260(wnt1)

HOC:	132805689(wnt1)

LERI:

129714702(wnt1)

PMRN:

116949033(WNT1)

LRJ:	133344981(WNT1)

BFO:

118405857

BBEL:

109465431

SCLV:

120330262

SPU:	373498(wnt1)

LPIC:

129263586

APLC:

110984810

ARUN:

117291877

SKO:	100303492(Wnt1)

DME:	Dmel_CG4889(wg)

DER:

6543349

DSE:

6611514

DSI:	Dsimw501_GD28595(Dsim_GD28595)

DYA:	Dyak_GE14450

DAN:

6508748

DSR:	110180312 110182678

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI23655

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108357997 108378188

AOQ:

129246905

TDA:

119662403

MDE:	101888781 105262002

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

109404800 109419326 115265601

ASUA:

134213327

CQU:	CpipJ_CPIJ005837

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105676098(wg)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	656348(Wg)

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

692745(WNT-1)

BMAN:

114248784

MSEX:

115456297 115456302 119192566

DPL:	KGM_214087

BANY:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:	110371067(Wg)

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

CCRN:

API:

DNX:	107168913 107172197

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106684260(wg)

NLU:

111054151

HVI:

124364136

MQU:

128999811

PHU:	Phum_PHUM151650

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_290640(WNT1)

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

PPOI:

ISC:

DSV:

RSAN:

RMP:

DPTE:

DFR:

CSCU:

CVS:	136969362 136989394(wg)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

HRO:	HELRODRAFT_63913

LGI:	LOTGIDRAFT_170942

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:	106180562 106180563

OVI:	T265_13080

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:	100204240(hywnt1)

HSY:

130642145

RES:

135681603

» show all

Reference

PMID:12591239

Authors

Lekven AC, Buckles GR, Kostakis N, Moon RT

Title

Wnt1 and wnt10b function redundantly at the zebrafish midbrain-hindbrain boundary.

Journal

Dev Biol 254:172-87 (2003)
DOI:10.1016/S0012-1606(02)00044-1

Sequence

[dre:30128]

Reference

PMID:2998762

Authors

van Ooyen A, Kwee V, Nusse R

Title

The nucleotide sequence of the human int-1 mammary oncogene; evolutionary conservation of coding and non-coding sequences.

Journal

EMBO J 4:2905-9 (1985)
DOI:10.1002/j.1460-2075.1985.tb04021.x

Sequence

[hsa:7471]

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