KEGG   ORTHOLOGY: K03388
Entry
K03388                      KO                                     

Name
hdrA2
Definition
heterodisulfide reductase subunit A2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K03388  hdrA2; heterodisulfide reductase subunit A2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.7  With an iron-sulfur protein as acceptor
    1.8.7.3  ferredoxin:CoB-CoM heterodisulfide reductase
     K03388  hdrA2; heterodisulfide reductase subunit A2
   1.8.98  With other, known, physiological acceptors
    1.8.98.4  coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase
     K03388  hdrA2; heterodisulfide reductase subunit A2
    1.8.98.5  H2:CoB-CoM heterodisulfide,ferredoxin reductase
     K03388  hdrA2; heterodisulfide reductase subunit A2
    1.8.98.6  formate:CoB-CoM heterodisulfide,ferredoxin reductase
     K03388  hdrA2; heterodisulfide reductase subunit A2
Other DBs
RN: R11928 R11931 R11943 R11944
COG: COG1148
Genes
TMB: Thimo_0253
HHC: M911_11230
EBS: ECTOBSL9_0285
TGR: Tgr7_2214
TKM: TK90_0634
TNI: TVNIR_3247(hdrA_[H])
TVR: TVD_10640
APRS: BI364_13805
ACII: C4901_12970
CBX: Cenrod_2147(hdrA)
SPLB: SFPGR_29450(hdrA)
SNIV: SFSGTM_27290(hdrA)
SLAC: SKTS_06230(hdrA-2)
GSU: GSU0090(hdrA)
GSK: KN400_0065(hdrA)
GME: Gmet_2084(bamE) Gmet_3426(hdrA)
GLO: Glov_0864
GBM: Gbem_0030(hdrA) Gbem_1447(bamE)
GEO: Geob_0215(bamE-1) Geob_0231(bamE-2) Geob_3723(hdrA)
DVU: DVU2402(hdrA)
DVL: Dvul_0828
DVM: DvMF_0324
DDS: Ddes_2100
DMA: DMR_01920(hdrA) DMR_22120
DGG: DGI_1050(hdrA)
DTR: RSDT_0567(hdrA)
DHY: DESAM_21330(hdrA)
DPI: BN4_11860(hdrA)
DPS: DP1010
DOL: Dole_1159
DML: Dmul_02770(hdrA1) Dmul_24500(bamE) Dmul_28860(hdrA2)
DAT: HRM2_06460 HRM2_11710(hdrA1) HRM2_11850(hdrA2) HRM2_14330(hdrA3) HRM2_14340(hdrA3') HRM2_22750(hdrA4)
DTO: TOL2_C03750(bamE1) TOL2_C11590(hdlA2) TOL2_C11630(hdlA3?) TOL2_C17900(hdlA5) TOL2_C24180(hdlA6) TOL2_C25730(hdlA7) TOL2_C28760(hdlA8) TOL2_C28830(hdlA9) TOL2_C41400(bamE2) TOL2_C43540(bamE3)
ADE: Adeh_4164
HDN: Hden_0691
BLAG: BLTE_14930(hdrA-2)
RHC: RGUI_1281
AFR: AFE_2553
ATX: GCD22_03148(hdrA) GCD22_03279(hdrA)
BTS: Btus_2496
RCH: RUM_10980
BPRO: PMF13cell1_01672(ndhI_2)
SWO: Swol_0397
SALQ: SYNTR_0264
PTH: PTH_1410(HdrA)
SGY: Sgly_1900
HMO: HM1_2008(hdrA)
SAY: TPY_3529(hdrA)
MTA: Moth_1453
MTHZ: MOTHA_c08510(ndhI3) MOTHA_c15280(mnmC2)
STED: SPTER_13760(mnmC)
AFO: Afer_0966
DFO: Dform_00920(hdrA) Dform_00941(hdrA)
TRO: trd_0153
OTE: Oter_3677
APS: CFPG_240
AFD: Alfi_2101
ASH: AL1_26630
BACC: BRDCF_p1060 BRDCF_p823(hdrA) BRDCF_p824(hdrA2)
CTE: CT1246(hdrA-2)
CPC: Cpar_0949
CCH: Cag_1029
CLI: Clim_1200
PVI: Cvib_0843
PLT: Plut_1109
PPH: Ppha_1306
CTS: Ctha_0136
AAE: aq_395(hdrA)
HTH: HTH_1881(hdrA)
TAL: Thal_1346
CABY: Cabys_1917
CTHI: THC_1756
BANA: BARAN1_0338(hdrA)
MMP: MMP0825(hdrA) MMP1697(hdrA)
MMD: GYY_04785
MMAK: MMKA1_09100(hdrA) MMKA1_19310(hdrA)
MMAO: MMOS7_08880(hdrA) MMOS7_18120(hdrA)
MMAD: MMJJ_01720(hdrA) MMJJ_11320(hdrA2)
MTH: MTH_1381
MMG: MTBMA_c17680(hdrA)
METC: MTCT_1255
MWO: MWSIV6_1762(hdrA)
METE: tca_01335(rsxB_2)
MST: Msp_1476(hdrA1)
MRU: mru_0117(hdrA)
MSI: Msm_1336
MEB: Abm4_1691(hdrA2)
MMIL: sm9_2251(hdrA2)
MEYE: TL18_00375
MOL: YLM1_1554
METH: MBMB1_1958(hdrA)
MFC: BRM9_2298(hdrA2)
MFI: DSM1535_1232(hdrA)
MCUB: MCBB_2243(hdrA3)
MFV: Mfer_0184
MKA: MK0249(hdrA_1) MK0265(hdrA_2)
MBAR: MSBR2_0910
MBAK: MSBR3_0798
MAC: MA_2868(hdrA)
MMA: MM_0056
METM: MSMTP_1469
MTHR: MSTHT_0375
MTHE: MSTHC_0346
MBU: Mbur_0552(hdrA)
MMET: MCMEM_1365
MMH: Mmah_0955
MTP: Mthe_1576
MCJ: MCON_3279(hdrA)
MHI: Mhar_0607
MBG: BN140_0752(hdrA1) BN140_1728(hdrA3)
MEMA: MMAB1_0971(hdrA) MMAB1_2223(hdrA)
MPD: MCP_1576(hdrA-1) MCP_2768(hdrA-2)
MEZ: Mtc_2473(hdrA-2)
RCI: RCIX596(hdrA-2) RRC258(hdrA-3)
HDF: AArcSl_1855(hdrA)
MEAR: Mpt1_c10580(hdrA)
MARC: AR505_1479
ABI: Aboo_0977
STO: STK_18730
SSO: SSO1131(hdrA)
SOL: Ssol_2101
SSOA: SULA_2132
SSOL: SULB_2133
SSOF: SULC_2131
SAI: Saci_0328(hdrA)
SID: M164_1089
SII: LD85_1217
SIH: SiH_1060
SIR: SiRe_0973
SIC: SiL_0979
MSE: Msed_1545
MCN: Mcup_0686
AHO: Ahos_1694
STEP: IC006_0777
BARC: AOA65_1112(hdrA_1) AOA65_1402(hdrA_3) AOA65_1719(hdlA_2) AOA65_1995(hdrA_4)
BARB: AOA66_0155(hdrA_1) AOA66_1510(hdrA_2) AOA66_1512(hdlA_2) AOA66_1513(hdrA_3) AOA66_1526(hdrA_4)
LOKI: Lokiarch_00290(hdrA_1) Lokiarch_01240(hdrA_2) Lokiarch_08680(hdrA_4) Lokiarch_09900(hdrA_5) Lokiarch_10040(hdlA_3) Lokiarch_17940(hdlA_5) Lokiarch_23600(hdrA_8) Lokiarch_25880(hdrA_9) Lokiarch_28050(hdrA_10) Lokiarch_40200(hdrA_13) Lokiarch_41160(hdrA_15) Lokiarch_49330(hdrA_16)
PSYT: DSAG12_01136(hdrA_1) DSAG12_01147(hdrA_2) DSAG12_02253(hdrA_3) DSAG12_02805(hdrA_4) DSAG12_03220(hdrA_5) DSAG12_03721(hdrA_6) DSAG12_03723(hdlA_4) DSAG12_03724(hdrA_7)
 » show all
Reference
PMID:2121478
  Authors
Hedderich R, Berkessel A, Thauer RK
  Title
Purification and properties of heterodisulfide reductase from Methanobacterium thermoautotrophicum (strain Marburg).
  Journal
Eur J Biochem 193:255-61 (1990)
DOI:10.1111/j.1432-1033.1990.tb19331.x
  Sequence
Reference
PMID:8119281
  Authors
Setzke E, Hedderich R, Heiden S, Thauer RK
  Title
H2: heterodisulfide oxidoreductase complex from Methanobacterium thermoautotrophicum. Composition and properties.
  Journal
Eur J Biochem 220:139-48 (1994)
DOI:10.1111/j.1432-1033.1994.tb18608.x
  Sequence
Reference
  Authors
Mander GJ, Pierik AJ, Huber H, Hedderich R
  Title
Two distinct heterodisulfide reductase-like enzymes in the sulfate-reducing archaeon Archaeoglobus profundus.
  Journal
Eur J Biochem 271:1106-16 (2004)
DOI:10.1111/j.1432-1033.2004.04013.x
  Sequence
[apo:Arcpr_1555] [afu:AF_1377]

KEGG   ORTHOLOGY: K03389
Entry
K03389                      KO                                     

Name
hdrB2
Definition
heterodisulfide reductase subunit B2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K03389  hdrB2; heterodisulfide reductase subunit B2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.7  With an iron-sulfur protein as acceptor
    1.8.7.3  ferredoxin:CoB-CoM heterodisulfide reductase
     K03389  hdrB2; heterodisulfide reductase subunit B2
   1.8.98  With other, known, physiological acceptors
    1.8.98.4  coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase
     K03389  hdrB2; heterodisulfide reductase subunit B2
    1.8.98.5  H2:CoB-CoM heterodisulfide,ferredoxin reductase
     K03389  hdrB2; heterodisulfide reductase subunit B2
    1.8.98.6  formate:CoB-CoM heterodisulfide,ferredoxin reductase
     K03389  hdrB2; heterodisulfide reductase subunit B2
Other DBs
RN: R11928 R11931 R11943 R11944
COG: COG2048
Genes
TIG: THII_2280
THIS: HZT40_21385
TVI: Thivi_3111
TMB: Thimo_0248
TSY: THSYN_16425
HHC: M911_11215 M911_11235
EBS: ECTOBSL9_0282 ECTOBSL9_0286
TGR: Tgr7_2211 Tgr7_2215
TKM: TK90_0633 TK90_0637
TNI: TVNIR_3244(hdrB_[H]) TVNIR_3248(hdlB_[H])
SLIM: SCL_2520
TBN: TBH_C2777
ENM: EBS_2145(hdrB)
SHD: SUTH_02769(hdrB)
TBD: Tbd_1645
SDR: SCD_n01881(hdrB)
SLAC: SKTS_06180(hdrB) SKTS_11890
GSU: GSU0091(hdrB)
GSK: KN400_0066(hdrB)
GME: Gmet_3425(hdrB)
GLO: Glov_0862
GBM: Gbem_0031(hdrB)
GEO: Geob_3724(hdrB)
GEM: GM21_0030
GBN: GEOBRER4_00290(hdrB)
DVU: DVU2403(hdrB)
DVL: Dvul_0827
DVM: DvMF_0323
DDS: Ddes_2099
DMA: DMR_01910(hdrB)
DGG: DGI_1049(hdrB)
DTR: RSDT_0566(hdrB)
DAS: Daes_0784
DPI: BN4_11859(hdrB)
DOL: Dole_1160
DML: Dmul_28870(hdrB)
DAT: HRM2_22770(hdrD2')
SFU: Sfum_0819
BLAG: BLTE_14980
ATX: GCD22_01577(hdrB1) GCD22_02661(hdrB1) GCD22_03145(hdrB) GCD22_03149(hdrB1) GCD22_03192(hdrB1)
RCH: RUM_10960
RUM: CK1_05040
BPRO: PMF13cell1_01670(lutA)
SWO: Swol_0395
SALQ: SYNTR_0262
PTH: PTH_1412(HdrB)
SGY: Sgly_1901
HMO: HM1_2007
HCV: FTV88_1703(hdrB)
CHY: CHY_0929
ADG: Adeg_1334
TACI: TDSAC_1307
STED: SPTER_13750(sdhE_1)
DFO: Dform_00942(hdrB)
OTE: Oter_3676
TTF: THTE_4308
APS: CFPG_239
AFD: Alfi_2100
CTE: CT1245
CPC: Cpar_0950
CCH: Cag_1028
CLI: Clim_1201
PVI: Cvib_0844
PLT: Plut_1108
PPH: Ppha_1307
AAE: aq_400(hdrB)
HTH: HTH_1878(hdrB1) HTH_1882(hdrB2)
TTK: TST_1519(hdrB)
CABY: Cabys_1918
MMP: MMP1053(hdrB2) MMP1155(hdrB1)
MMAK: MMKA1_12180(hdrB) MMKA1_13330(hdrB)
MMAO: MMOS7_11480(hdrB) MMOS7_12630(hdrB)
MMAD: MMJJ_16900 MMJJ_17970(lutA)
MAE: Maeo_0308
METF: CFE53_06410(hdrB)
MTH: MTH_1879
MMG: MTBMA_c04500(hdrB)
METC: MTCT_1717
MWO: MWSIV6_0410(hdrB)
METE: tca_01815(lutA)
METK: FVF72_02310(hdrB)
MTHM: FZP57_01925(hdrB)
MST: Msp_1013(hdrB1)
MRU: mru_0817(hdrB1)
MSI: Msm_0795
MEB: Abm4_1308(hdrB2)
MMIL: sm9_1716(hdrB3)
MEYE: TL18_07635
MOL: YLM1_0405
METH: MBMB1_1274(hdrB)
MFC: BRM9_0490(hdrB1)
MFI: DSM1535_0471(hdrB)
MCUB: MCBB_1489(hdrB3)
METT: CIT01_08470(hdrB)
METO: CIT02_11685(hdrB)
MFV: Mfer_0739
MKA: MK0572(hdrB)
AFU: AF_1375
MBAR: MSBR2_3160
MBAK: MSBR3_3156
MAC: MA_4237(hdrB)
METM: MSMTP_0364
MTHR: MSTHT_1573
MTHE: MSTHC_1716
MFZ: AOB57_006960(hdrB)
MBU: Mbur_1517(hdrB)
MMET: MCMEM_1990
MMH: Mmah_1786
MZI: HWN40_01880(hdrB)
MTP: Mthe_1573
MCJ: MCON_3283(hdrB)
MHI: Mhar_0604
MHU: Mhun_1837
MLA: Mlab_0240
MBG: BN140_1727(hdrB)
MEMA: MMAB1_2222(hdrB)
MBN: Mboo_0589
MPL: Mpal_2240
MPD: MCP_1577(hdrB-1) MCP_2769(hdrB-3)
MEZ: Mtc_2474(hdrB-2)
RCI: RCIX595(hdrB-2) RRC257(hdrB-3)
MEAR: Mpt1_c02970(hdrB1) Mpt1_c08830(hdrB2)
MARC: AR505_0274
ABI: Aboo_0976
SSO: SSO1129(hdrB-1) SSO1135(hdrB-2)
SAI: Saci_0325(hdrB) Saci_0329
KCR: Kcr_0767
BARC: AOA65_1401(hdrB_2) AOA65_1887(hdrB_3) AOA65_1993(hdrB_4)
BARB: AOA66_1507(hdrB_1) AOA66_1731(hdrB_2)
LOKI: Lokiarch_01260(hdrB_1) Lokiarch_23590(hdrB_2) Lokiarch_39150(hdrB_3) Lokiarch_45510(hdrB_4)
PSYT: DSAG12_01137(hdrB_1) DSAG12_01146(hdrB_2) DSAG12_01161(hdrB_3) DSAG12_02807(hdrB_4) DSAG12_03223(hdrB_5) DSAG12_03725(hdrB_6) DSAG12_03952(hdrB_7)
 » show all
Reference
PMID:2121478
  Authors
Hedderich R, Berkessel A, Thauer RK
  Title
Purification and properties of heterodisulfide reductase from Methanobacterium thermoautotrophicum (strain Marburg).
  Journal
Eur J Biochem 193:255-61 (1990)
DOI:10.1111/j.1432-1033.1990.tb19331.x
  Sequence
Reference
PMID:8119281
  Authors
Setzke E, Hedderich R, Heiden S, Thauer RK
  Title
H2: heterodisulfide oxidoreductase complex from Methanobacterium thermoautotrophicum. Composition and properties.
  Journal
Eur J Biochem 220:139-48 (1994)
DOI:10.1111/j.1432-1033.1994.tb18608.x
  Sequence
Reference
  Authors
Mander GJ, Pierik AJ, Huber H, Hedderich R
  Title
Two distinct heterodisulfide reductase-like enzymes in the sulfate-reducing archaeon Archaeoglobus profundus.
  Journal
Eur J Biochem 271:1106-16 (2004)
DOI:10.1111/j.1432-1033.2004.04013.x
  Sequence
[apo:Arcpr_1553] [afu:AF_1375]

KEGG   ORTHOLOGY: K03390
Entry
K03390                      KO                                     

Name
hdrC2
Definition
heterodisulfide reductase subunit C2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K03390  hdrC2; heterodisulfide reductase subunit C2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.7  With an iron-sulfur protein as acceptor
    1.8.7.3  ferredoxin:CoB-CoM heterodisulfide reductase
     K03390  hdrC2; heterodisulfide reductase subunit C2
   1.8.98  With other, known, physiological acceptors
    1.8.98.4  coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase
     K03390  hdrC2; heterodisulfide reductase subunit C2
    1.8.98.5  H2:CoB-CoM heterodisulfide,ferredoxin reductase
     K03390  hdrC2; heterodisulfide reductase subunit C2
    1.8.98.6  formate:CoB-CoM heterodisulfide,ferredoxin reductase
     K03390  hdrC2; heterodisulfide reductase subunit C2
Other DBs
RN: R11928 R11931 R11943 R11944
COG: COG1150
Genes
TMB: Thimo_0247
HHC: M911_11220
EBS: ECTOBSL9_0283
TGR: Tgr7_2212
TKM: TK90_0636
TNI: TVNIR_3245(hdlC_[H])
TVR: TVD_10630
APRS: BI364_13795
ACII: C4901_12960
SULF: CAP31_01860
SPLB: SFPGR_29430(hdrC)
SNIV: SFSGTM_27270(hdrC)
SLAC: SKTS_06170
GSU: GSU0092(hdrC)
GSK: KN400_0067(hdrC)
GME: Gmet_3424(hdrC)
GLO: Glov_0861
GBM: Gbem_0032(hdrC)
GEO: Geob_3725(hdrC)
GEM: GM21_0031
GBN: GEOBRER4_00300(hdrC)
DVU: DVU2404(hdrC)
DVL: Dvul_0826
DVM: DvMF_0322
DDS: Ddes_2098
DMA: DMR_01900(hdrC)
DGG: DGI_1048(hdrC)
DTR: RSDT_0565(hdrC)
DAS: Daes_0783
DPI: BN4_11858(hdrC)
DSF: UWK_01755
DOL: Dole_1161
DML: Dmul_28880(hdrC)
DAT: HRM2_22760(hdrD2)
DTO: TOL2_C17910(hdlC)
SFU: Sfum_0820
DBR: Deba_2022
HDN: Hden_0693
BLAG: BLTE_14840
RHC: RGUI_1279
AFR: AFE_2551
ACU: Atc_2348
ATX: GCD22_03146(hdlC)
RCH: RUM_10970
RUM: CK1_05050
BPRO: PMF13cell1_01671(rsxC_1)
SWO: Swol_0394
SLP: Slip_2075
SALQ: SYNTR_0261
PTH: PTH_1413(GlpC)
DAU: Daud_0563
SGY: Sgly_1902
HMO: HM1_2006
CHY: CHY_0927
DFO: Dform_00943(hdrC)
APS: CFPG_238
AAE: aq_391 aq_398(hdrC)
HTH: HTH_1879(hdrC1) HTH_1883(hdrC2)
TTK: TST_1518(hdrC)
BANA: BARAN1_0333(hdrC)
MMP: MMP1054(hdrC2) MMP1154(hdrC1)
MMAK: MMKA1_12190(hdrC) MMKA1_13320(hdrC)
MMAO: MMOS7_11490(hdrC) MMOS7_12620(hdrC)
MAE: Maeo_0307
METF: CFE53_02215(hdrC) CFE53_06415(hdrC)
MTH: MTH_1878
MMG: MTBMA_c04490(hdrC)
METC: MTCT_1716
MWO: MWSIV6_0409(hdrC)
METE: tca_01814
METK: FVF72_02315(hdrC)
MTHM: FZP57_01920(hdrC)
MST: Msp_1014(hdrC1)
MRU: mru_0816(hdrC)
MSI: Msm_0796
MEB: Abm4_1309(hdrC2)
MMIL: sm9_1717(hdrC2)
MEYE: TL18_07640
MOL: YLM1_0404
METH: MBMB1_1275
MFC: BRM9_0491(hdrC1)
MFI: DSM1535_0472(hdrC)
MCUB: MCBB_1490(hdrC3)
METT: CIT01_08465(hdrC)
METO: CIT02_11680(hdrC)
MFV: Mfer_0740
MKA: MK0573(hdrC)
AFU: AF_1376
GAH: GAH_01704
MBAR: MSBR2_3161
MBAK: MSBR3_3157
MAC: MA_4236(hdrC)
MMA: MM_0979
METM: MSMTP_0365
MTHR: MSTHT_1572
MTHE: MSTHC_1717
MFZ: AOB57_006955(hdrC)
MBU: Mbur_1516(hdrC)
MMET: MCMEM_1991
MMH: Mmah_1787
MZI: HWN40_01885(hdrC)
MTP: Mthe_1574
MCJ: MCON_3282(hdrC)
MHI: Mhar_0605
MHU: Mhun_1836
MLA: Mlab_0239
MBG: BN140_1726(hdrC)
MEMA: MMAB1_2221(hdrC)
MBN: Mboo_0590
MPL: Mpal_2241
MPD: MCP_1578(hdrC-1) MCP_2770(hdrC-3)
MEZ: Mtc_2475(hdrC-2)
RCI: RCIX594(hdrC-2) RRC256(hdrC-3)
MEAR: Mpt1_c02960(hdrC1) Mpt1_c08840(hdrC2)
MARC: AR505_0273
ABI: Aboo_0975
SSO: SSO1127(hdrC-1) SSO1134(hdrC-2)
SAI: Saci_0326 Saci_0334(hdrC)
VDI: Vdis_0690
VMO: VMUT_2339
KCR: Kcr_0766
BARC: AOA65_0030(hdrC_1) AOA65_1400(hdrC_2) AOA65_1888(hdrC_3) AOA65_1994(hdrC_4)
BARB: AOA66_1508(hdrC_1) AOA66_1732(hdrC_2)
LOKI: Lokiarch_01250(hdrC_1) Lokiarch_03060(hdrC_2) Lokiarch_23580(hdrC_3) Lokiarch_23870(hdrC_4) Lokiarch_39160(hdrC_5) Lokiarch_45500(hdrC_6)
PSYT: DSAG12_01138(hdrC_1) DSAG12_01145(hdrC_2) DSAG12_01162(hdrC_3) DSAG12_02806(hdrC_4) DSAG12_03218(hdrC_5) DSAG12_03726(hdrC_6) DSAG12_03953(hdrC_7)
 » show all
Reference
PMID:2121478
  Authors
Hedderich R, Berkessel A, Thauer RK
  Title
Purification and properties of heterodisulfide reductase from Methanobacterium thermoautotrophicum (strain Marburg).
  Journal
Eur J Biochem 193:255-61 (1990)
DOI:10.1111/j.1432-1033.1990.tb19331.x
  Sequence
Reference
PMID:8119281
  Authors
Setzke E, Hedderich R, Heiden S, Thauer RK
  Title
H2: heterodisulfide oxidoreductase complex from Methanobacterium thermoautotrophicum. Composition and properties.
  Journal
Eur J Biochem 220:139-48 (1994)
DOI:10.1111/j.1432-1033.1994.tb18608.x
  Sequence
Reference
  Authors
Mander GJ, Pierik AJ, Huber H, Hedderich R
  Title
Two distinct heterodisulfide reductase-like enzymes in the sulfate-reducing archaeon Archaeoglobus profundus.
  Journal
Eur J Biochem 271:1106-16 (2004)
DOI:10.1111/j.1432-1033.2004.04013.x
  Sequence

KEGG   ORTHOLOGY: K14126
Entry
K14126                      KO                                     

Name
mvhA, vhuA, vhcA
Definition
F420-non-reducing hydrogenase large subunit [EC:1.12.99.- 1.8.98.5]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K14126  mvhA, vhuA, vhcA; F420-non-reducing hydrogenase large subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.98  With other, known, physiological acceptors
    1.8.98.5  H2:CoB-CoM heterodisulfide,ferredoxin reductase
     K14126  mvhA, vhuA, vhcA; F420-non-reducing hydrogenase large subunit
  1.12  Acting on hydrogen as donor
   1.12.99  With unknown physiological acceptors
    1.12.99.-  
     K14126  mvhA, vhuA, vhcA; F420-non-reducing hydrogenase large subunit
Other DBs
RN: R00019 R11943
COG: COG3259
Genes
CBX: Cenrod_2145(mvhA)
GSU: GSU2419(mvhL)
GSK: KN400_2367(mvhL)
GME: Gmet_3320(mvhL)
GLO: Glov_1553
GBM: Gbem_3884(mvhL)
GEM: GM21_3972
GAO: A2G06_05470
GBN: GEOBRER4_05360 GEOBRER4_37760(mvhL)
DSD: GD606_02930
DRT: Dret_2258
DPS: DP1013
DAL: Dalk_4962
DAT: HRM2_11740(mvhA)
ADE: Adeh_4162
DAU: Daud_1651
ADG: Adeg_2013
TACI: TDSAC_1304
DET: DET0615
DEH: cbdbA597
DEV: DhcVS_553(vhuA)
DMC: btf_575(vhcA)
DMD: dcmb_621(vhcA)
DMG: GY50_0541(mvhA)
DFO: Dform_00937(mvhA|vhcA)
OTE: Oter_3680
TTF: THTE_4313
CABY: Cabys_1914
BANA: BARAN1_0335(mvhA)
MJA: MJ_1192
MMP: MMP0823(vhcA) MMP1694(vhuA)
MMAK: MMKA1_09080(vhcA) MMKA1_19280(vhuA)
MMAO: MMOS7_08860(vhcA) MMOS7_18090(vhuA)
MMAD: MMJJ_01740(vhcA) MMJJ_11350(vhuA)
MTH: MTH_1134
MMG: MTBMA_c15170(mvhA)
METC: MTCT_1027
MWO: MWSIV6_1526(mvhA)
METE: tca_01090(hoxH)
MST: Msp_0316(mvhA)
MRU: mru_1906(mvhA)
MSI: Msm_0999
MEB: Abm4_1510(mvhA)
MMIL: sm9_2011(mvhA)
MEYE: TL18_09240
MOL: YLM1_1362
METH: MBMB1_1340(mvhA1) MBMB1_1661(mvhA3)
MFC: BRM9_0563(mvhA1) BRM9_0913(mvhA2)
MFI: DSM1535_0544(vhcA) DSM1535_0881(mvhA)
MCUB: MCBB_1580(vhcA) MCBB_1966(mvhA)
MFV: Mfer_0729
AFU: AF_1372
FPL: Ferp_0841
GAC: GACE_0711
GAH: GAH_02038
MBG: BN140_1835(mvhA)
MEMA: MMAB1_2368(vhcA)
MPI: Mpet_2718
MPD: MCP_2492(mvhA-1) MCP_2774(mvhA-2)
MEZ: Mtc_0109(mvhA-1) Mtc_2479(mvhA-2)
RCI: RCIX473(mvhA-1) RCIX590(mvhA-2)
MEAR: Mpt1_c10550(mvhA)
MARC: AR505_1476
KCR: Kcr_1119
BARC: AOA65_1722 AOA65_1885(mvhA)
BARB: AOA66_1505(mvhA_2)
PSYT: DSAG12_03951(vhcA)
 » show all
Reference
  Authors
Stojanowic A, Mander GJ, Duin EC, Hedderich R
  Title
Physiological role of the F420-non-reducing hydrogenase (Mvh) from Methanothermobacter marburgensis.
  Journal
Arch Microbiol 180:194-203 (2003)
DOI:10.1007/s00203-003-0577-9
  Sequence

KEGG   ORTHOLOGY: K14128
Entry
K14128                      KO                                     

Name
mvhG, vhuG, vhcG
Definition
F420-non-reducing hydrogenase small subunit [EC:1.12.99.- 1.8.98.5]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K14128  mvhG, vhuG, vhcG; F420-non-reducing hydrogenase small subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.98  With other, known, physiological acceptors
    1.8.98.5  H2:CoB-CoM heterodisulfide,ferredoxin reductase
     K14128  mvhG, vhuG, vhcG; F420-non-reducing hydrogenase small subunit
  1.12  Acting on hydrogen as donor
   1.12.99  With unknown physiological acceptors
    1.12.99.-  
     K14128  mvhG, vhuG, vhcG; F420-non-reducing hydrogenase small subunit
Other DBs
RN: R00019 R11943
COG: COG1941
Genes
CBX: Cenrod_2144(mvhG)
GSU: GSU2418(mvhS)
GSK: KN400_2366(mvhS)
GME: Gmet_3319(mvhS)
GLO: Glov_1552
GBM: Gbem_3885(mvhS)
GEM: GM21_3973
GAO: A2G06_05475
GBN: GEOBRER4_05350 GEOBRER4_37770(mvhS)
DSD: GD606_02925
DRT: Dret_2259
DPS: DP1012
DAL: Dalk_4963
DAT: HRM2_11730(mvhG)
ADE: Adeh_4163
DAU: Daud_1652
ADG: Adeg_2014
TACI: TDSAC_1305
DET: DET0614
DEH: cbdbA596
DEV: DhcVS_552(vhuG)
DMC: btf_574(vhcG)
DMD: dcmb_620(vhcG)
DMG: GY50_0540(mvhG)
DFO: Dform_00938(mvhG|vhcG)
OTE: Oter_3679
TTF: THTE_4312
CABY: Cabys_1915
BANA: BARAN1_0336(mvhG)
MJA: MJ_1191
MMP: MMP0822(vhcG) MMP1695(vhuG)
MMAK: MMKA1_09070(vhcG) MMKA1_19290(vhuG)
MMAO: MMOS7_08850(vhcG) MMOS7_18100(vhuG)
MMAD: MMJJ_01750(vhcG) MMJJ_11340(vhuG)
MTH: MTH_1135
MMG: MTBMA_c15180(mvhG)
METC: MTCT_1028
MWO: MWSIV6_1527(mvhG)
METE: tca_01091(hoxY)
MST: Msp_0315(mvhG)
MRU: mru_1907(mvhG)
MSI: Msm_1000
MEB: Abm4_1511(mvhG)
MMIL: sm9_2012(mvhG)
MEYE: TL18_09245
MOL: YLM1_1363
METH: MBMB1_1339 MBMB1_1662(mvhG)
MFC: BRM9_0562(mvhG1) BRM9_0914(mvhG2)
MCUB: MCBB_1579(vhuG) MCBB_1967(mvhG)
MFV: Mfer_0728
AFU: AF_1373
FPL: Ferp_0840
GAC: GACE_0710
GAH: GAH_02037
MBG: BN140_1834(mvhG)
MEMA: MMAB1_2367(vhcG)
MPI: Mpet_2719
MPD: MCP_2493(mvhG-1) MCP_2773(mvhG-2)
MEZ: Mtc_0111(mvhG-1) Mtc_2478(mvhG-2)
RCI: RCIX474(mvhG-1) RCIX591(mvhG-2)
MEAR: Mpt1_c10560(mvhG)
MARC: AR505_1477
KCR: Kcr_1118
BARC: AOA65_1723 AOA65_1886(mvhG)
BARB: AOA66_1506(mvhG)
PSYT: DSAG12_01149(mvhG_1) DSAG12_03954(mvhG_2)
 » show all
Reference
  Authors
Stojanowic A, Mander GJ, Duin EC, Hedderich R
  Title
Physiological role of the F420-non-reducing hydrogenase (Mvh) from Methanothermobacter marburgensis.
  Journal
Arch Microbiol 180:194-203 (2003)
DOI:10.1007/s00203-003-0577-9
  Sequence

KEGG   ORTHOLOGY: K14127
Entry
K14127                      KO                                     

Name
mvhD, vhuD, vhcD
Definition
F420-non-reducing hydrogenase iron-sulfur subunit [EC:1.12.99.- 1.8.98.5 1.8.98.6]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K14127  mvhD, vhuD, vhcD; F420-non-reducing hydrogenase iron-sulfur subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.98  With other, known, physiological acceptors
    1.8.98.5  H2:CoB-CoM heterodisulfide,ferredoxin reductase
     K14127  mvhD, vhuD, vhcD; F420-non-reducing hydrogenase iron-sulfur subunit
    1.8.98.6  formate:CoB-CoM heterodisulfide,ferredoxin reductase
     K14127  mvhD, vhuD, vhcD; F420-non-reducing hydrogenase iron-sulfur subunit
  1.12  Acting on hydrogen as donor
   1.12.99  With unknown physiological acceptors
    1.12.99.-  
     K14127  mvhD, vhuD, vhcD; F420-non-reducing hydrogenase iron-sulfur subunit
Other DBs
RN: R00019 R11943 R11944
COG: COG1908
Genes
TMB: Thimo_0254
CBX: Cenrod_2148(mvhD)
SLAC: SKTS_06250
GSK: KN400_0064(hdrG)
GME: Gmet_2083(bamF)
GUR: Gura_0148 Gura_3584
GLO: Glov_0865
GBM: Gbem_1448(bamF)
GEO: Geob_0216(bamF-1) Geob_0232(bamF-2) Geob_3721(hdrG)
GEM: GM21_2806
DMA: DMR_01930
DGG: DGI_1051(floxD)
DHY: DESAM_21329(vhcD)
DAS: Daes_0780
DPI: BN4_11861(mvhD)
DBA: Dbac_0851
DPS: DP1011
DOL: Dole_1158
DML: Dmul_28840(mvhD2)
DAT: HRM2_11720(mvhD2) HRM2_11860(mvhD3) HRM2_14350(mvhD4) HRM2_30880(mvhD7)
DTO: TOL2_C03740(bamF1) TOL2_C09050(mvhD1) TOL2_C11600(mvhD2) TOL2_C11640(mvhD3) TOL2_C17880(mvhD4) TOL2_C24190(mvhD5) TOL2_C25720(mvhD6) TOL2_C28770(mvhD7) TOL2_C28840(mvhD8) TOL2_C32340 TOL2_C33290(mvhD9) TOL2_C43530(bamF3)
BLAG: BLTE_14920(hdrG)
RCH: RUM_10990
RUM: CK1_05070
SWO: Swol_0398
SALQ: SYNTR_0265
DAE: Dtox_1354
PTH: PTH_1409(FrhD)
SGY: Sgly_1899
HCV: FTV88_1705(mvhD)
DFO: Dform_00940(mvhD|vhcD)
OTE: Oter_3678
TTF: THTE_4311
APS: CFPG_241
BACC: BRDCF_p825
MBAS: ALGA_3489
CPC: Cpar_0948
CCH: Cag_1030
CLI: Clim_1199
PVI: Cvib_0842
PLT: Plut_1110
PPH: Ppha_1305
CABY: Cabys_1916
TYE: THEYE_A1367(vhuD)
CTHI: THC_1757
BANA: BARAN1_0337(mvhD)
MMP: MMP0821(vhcD) MMP1696(vhuD)
MMAK: MMKA1_09060(vhcD) MMKA1_19300(vhuD)
MMAO: MMOS7_08840(vhcD) MMOS7_18110(vhuD)
MMAD: MMJJ_01760(vhcD) MMJJ_11330(vhuD)
MWO: MWSIV6_1528(mvhD) MWSIV6_1530(vhcD)
MST: Msp_0314(mvhD1) Msp_0638(mvhD2)
MRU: mru_1908(mvhD1) mru_2076(mvhD2)
MEB: Abm4_0853(mvhD2) Abm4_1512(mvhD)
MMIL: sm9_1348(flpD) sm9_2013(mvhD)
METH: MBMB1_1663(mvhD)
MFC: BRM9_0915(mvhD)
MFI: DSM1535_0883(mvhD)
MCUB: MCBB_1968(mvhD) MCBB_2030(vhcD)
MKA: MK0268(flpD_1) MK0627(flpD_2)
AFU: AF_1374
FPL: Ferp_0839
GAC: GACE_0709
GAH: GAH_02036
MMAC: MSMAC_2580
MHOR: MSHOH_1796
MPY: Mpsy_2942
MHU: Mhun_1839
MBG: BN140_1729(MvhD)
MEMA: MMAB1_2224(vhcD)
MPI: Mpet_2476
MPD: MCP_2767(mvhD-2)
MEZ: Mtc_2472(mvhD-2)
RCI: RCIX597(mvhD-1)
MEAR: Mpt1_c10570(vhcD)
MARC: AR505_1478
VMO: VMUT_2343
KCR: Kcr_1117
BARC: AOA65_1715(mvhD_1) AOA65_1718(mvhD_2) AOA65_1889(vhcD)
BARB: AOA66_1509(vhcD) AOA66_1511(mvhD)
LOKI: Lokiarch_25870(mvhD_2)
PSYT: DSAG12_01135(mvhD_1) DSAG12_01148(mvhD_2) DSAG12_02804(mvhD_4) DSAG12_03720(vhcD) DSAG12_03722(mvhD_5)
 » show all
Reference
  Authors
Stojanowic A, Mander GJ, Duin EC, Hedderich R
  Title
Physiological role of the F420-non-reducing hydrogenase (Mvh) from Methanothermobacter marburgensis.
  Journal
Arch Microbiol 180:194-203 (2003)
DOI:10.1007/s00203-003-0577-9
  Sequence

KEGG   ENZYME: 1.8.98.5
Entry
EC 1.8.98.5                 Enzyme                                 

Name
H2:CoB-CoM heterodisulfide,ferredoxin reductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With other, known, physiological acceptors
Sysname
CoB,CoM,ferredoxin:H2 oxidoreductase
Reaction(IUBMB)
2 reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + 2 H+ = 2 H2 + 2 oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB [RN:R11943]
Reaction(KEGG)
R11943
Substrate
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
CoB [CPD:C04628];
CoM [CPD:C03576];
H+ [CPD:C00080]
Product
H2 [CPD:C00282];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139];
CoM-S-S-CoB [CPD:C04832]
Comment
This enzyme complex is found in H2-oxidizing CO2-reducing methanogenic archaea such as Methanothermobacter thermautotrophicus. It consists of a cytoplasmic complex of HdrABC reductase and MvhAGD hydrogenase. Electron pairs donated by the hydrogenase are transferred via its delta subunit to the HdrA subunit of the reductase, where they are bifurcated, reducing both ferredoxin and CoB-CoM heterodisulfide. The reductase can also form a similar complex with formate dehydrogenase, see EC 1.8.98.6, formate:CoB-CoM heterodisulfide,ferredoxin reductase. cf. EC 1.8.7.3, ferredoxin:CoB-CoM heterodisulfide reductase, EC 1.8.98.4, coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase, and EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase.
History
EC 1.8.98.5 created 2017
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K03388  heterodisulfide reductase subunit A2
K03389  heterodisulfide reductase subunit B2
K03390  heterodisulfide reductase subunit C2
K14126  F420-non-reducing hydrogenase large subunit
K14127  F420-non-reducing hydrogenase iron-sulfur subunit
K14128  F420-non-reducing hydrogenase small subunit
Genes
TIG: THII_2280
THIS: HZT40_21385
TVI: Thivi_3111
TMB: Thimo_0247 Thimo_0248 Thimo_0253 Thimo_0254
TSY: THSYN_16425
HHC: M911_11215 M911_11220 M911_11230 M911_11235
EBS: ECTOBSL9_0282 ECTOBSL9_0283 ECTOBSL9_0285 ECTOBSL9_0286
TGR: Tgr7_2211 Tgr7_2212 Tgr7_2214 Tgr7_2215
TKM: TK90_0633 TK90_0634 TK90_0636 TK90_0637
TNI: TVNIR_3244(hdrB_[H]) TVNIR_3245(hdlC_[H]) TVNIR_3247(hdrA_[H]) TVNIR_3248(hdlB_[H])
SLIM: SCL_2520
TBN: TBH_C2777
ENM: EBS_2145(hdrB)
CBX: Cenrod_2144(mvhG) Cenrod_2145(mvhA) Cenrod_2147(hdrA) Cenrod_2148(mvhD)
SHD: SUTH_02769(hdrB)
TBD: Tbd_1645
SDR: SCD_n01881(hdrB)
GSU: GSU0090(hdrA) GSU0091(hdrB) GSU0092(hdrC) GSU2418(mvhS) GSU2419(mvhL)
GSK: KN400_0064(hdrG) KN400_0065(hdrA) KN400_0066(hdrB) KN400_0067(hdrC) KN400_2366(mvhS) KN400_2367(mvhL)
GME: Gmet_2083(bamF) Gmet_2084(bamE) Gmet_3319(mvhS) Gmet_3320(mvhL) Gmet_3424(hdrC) Gmet_3425(hdrB) Gmet_3426(hdrA)
GBM: Gbem_0030(hdrA) Gbem_0031(hdrB) Gbem_0032(hdrC) Gbem_1447(bamE) Gbem_1448(bamF) Gbem_3884(mvhL) Gbem_3885(mvhS)
GEO: Geob_0215(bamE-1) Geob_0216(bamF-1) Geob_0231(bamE-2) Geob_0232(bamF-2) Geob_3721(hdrG) Geob_3723(hdrA) Geob_3724(hdrB) Geob_3725(hdrC)
DVU: DVU2402(hdrA) DVU2403(hdrB) DVU2404(hdrC)
DGG: DGI_1048(hdrC) DGI_1049(hdrB) DGI_1050(hdrA) DGI_1051(floxD)
DTR: RSDT_0565(hdrC) RSDT_0566(hdrB) RSDT_0567(hdrA)
DPI: BN4_11858(hdrC) BN4_11859(hdrB) BN4_11860(hdrA) BN4_11861(mvhD)
DML: Dmul_02770(hdrA1) Dmul_24500(bamE) Dmul_28840(mvhD2) Dmul_28860(hdrA2) Dmul_28870(hdrB) Dmul_28880(hdrC)
DAT: HRM2_06460 HRM2_11710(hdrA1) HRM2_11720(mvhD2) HRM2_11730(mvhG) HRM2_11740(mvhA) HRM2_11850(hdrA2) HRM2_11860(mvhD3) HRM2_14330(hdrA3) HRM2_14340(hdrA3') HRM2_14350(mvhD4) HRM2_22750(hdrA4) HRM2_22760(hdrD2) HRM2_22770(hdrD2') HRM2_30880(mvhD7)
DTO: TOL2_C02630 TOL2_C03740(bamF1) TOL2_C03750(bamE1) TOL2_C09050(mvhD1) TOL2_C11590(hdlA2) TOL2_C11600(mvhD2) TOL2_C11630(hdlA3?) TOL2_C11640(mvhD3) TOL2_C17880(mvhD4) TOL2_C17900(hdlA5) TOL2_C17910(hdlC) TOL2_C17920(hdlB) TOL2_C24180(hdlA6) TOL2_C24190(mvhD5) TOL2_C25720(mvhD6) TOL2_C25730(hdlA7) TOL2_C28760(hdlA8) TOL2_C28770(mvhD7) TOL2_C28830(hdlA9) TOL2_C28840(mvhD8) TOL2_C32340 TOL2_C33290(mvhD9) TOL2_C41400(bamE2) TOL2_C43530(bamF3) TOL2_C43540(bamE3)
ATX: GCD22_01577(hdrB1) GCD22_02661(hdrB1) GCD22_03145(hdrB) GCD22_03146(hdlC) GCD22_03148(hdrA) GCD22_03149(hdrB1) GCD22_03192(hdrB1) GCD22_03279(hdrA)
BTS: Btus_2496
PTH: PTH_1409(FrhD) PTH_1410(HdrA) PTH_1412(HdrB) PTH_1413(GlpC)
SAY: TPY_3529(hdrA)
AFO: Afer_0966
DEV: DhcVS_552(vhuG) DhcVS_553(vhuA)
DMC: btf_574(vhcG) btf_575(vhcA)
DMD: dcmb_620(vhcG) dcmb_621(vhcA)
DMG: GY50_0540(mvhG) GY50_0541(mvhA)
DFO: Dform_00920(hdrA) Dform_00937(mvhA|vhcA) Dform_00938(mvhG|vhcG) Dform_00940(mvhD|vhcD) Dform_00941(hdrA) Dform_00942(hdrB) Dform_00943(hdrC)
TRO: trd_0153
ASH: AL1_26630
CTE: CT1245 CT1246(hdrA-2)
CTS: Ctha_0136
AAE: aq_391 aq_395(hdrA) aq_398(hdrC) aq_400(hdrB)
HTH: HTH_1878(hdrB1) HTH_1879(hdrC1) HTH_1881(hdrA) HTH_1882(hdrB2) HTH_1883(hdrC2)
MMP: MMP0821(vhcD) MMP0822(vhcG) MMP0823(vhcA) MMP0825(hdrA) MMP1053(hdrB2) MMP1054(hdrC2) MMP1154(hdrC1) MMP1155(hdrB1) MMP1694(vhuA) MMP1695(vhuG) MMP1696(vhuD) MMP1697(hdrA)
MMAK: MMKA1_09060(vhcD) MMKA1_09070(vhcG) MMKA1_09080(vhcA) MMKA1_09100(hdrA) MMKA1_12180(hdrB) MMKA1_12190(hdrC) MMKA1_13320(hdrC) MMKA1_13330(hdrB) MMKA1_19280(vhuA) MMKA1_19290(vhuG) MMKA1_19300(vhuD) MMKA1_19310(hdrA)
MMAO: MMOS7_08840(vhcD) MMOS7_08850(vhcG) MMOS7_08860(vhcA) MMOS7_08880(hdrA) MMOS7_11480(hdrB) MMOS7_11490(hdrC) MMOS7_12620(hdrC) MMOS7_12630(hdrB) MMOS7_18090(vhuA) MMOS7_18100(vhuG) MMOS7_18110(vhuD) MMOS7_18120(hdrA)
MWO: MWSIV6_0409(hdrC) MWSIV6_0410(hdrB) MWSIV6_1526(mvhA) MWSIV6_1527(mvhG) MWSIV6_1528(mvhD) MWSIV6_1530(vhcD) MWSIV6_1762(hdrA)
MST: Msp_0314(mvhD1) Msp_0315(mvhG) Msp_0316(mvhA) Msp_0638(mvhD2) Msp_1013(hdrB1) Msp_1014(hdrC1) Msp_1476(hdrA1)
MRU: mru_0117(hdrA) mru_0816(hdrC) mru_0817(hdrB1) mru_1906(mvhA) mru_1907(mvhG) mru_1908(mvhD1) mru_2076(mvhD2)
MEB: Abm4_0853(mvhD2) Abm4_1308(hdrB2) Abm4_1309(hdrC2) Abm4_1510(mvhA) Abm4_1511(mvhG) Abm4_1512(mvhD) Abm4_1691(hdrA2)
MMIL: sm9_1348(flpD) sm9_1716(hdrB3) sm9_1717(hdrC2) sm9_2011(mvhA) sm9_2012(mvhG) sm9_2013(mvhD) sm9_2251(hdrA2)
MFC: BRM9_0490(hdrB1) BRM9_0491(hdrC1) BRM9_0562(mvhG1) BRM9_0563(mvhA1) BRM9_0913(mvhA2) BRM9_0914(mvhG2) BRM9_0915(mvhD) BRM9_2298(hdrA2)
MCUB: MCBB_1489(hdrB3) MCBB_1490(hdrC3) MCBB_1579(vhuG) MCBB_1580(vhcA) MCBB_1966(mvhA) MCBB_1967(mvhG) MCBB_1968(mvhD) MCBB_2030(vhcD) MCBB_2243(hdrA3)
MKA: MK0178 MK0179 MK0249(hdrA_1) MK0265(hdrA_2) MK0266 MK0267 MK0268(flpD_1) MK0572(hdrB) MK0573(hdrC) MK0627(flpD_2)
MAC: MA_2868(hdrA) MA_4236(hdrC) MA_4237(hdrB)
MBU: Mbur_0552(hdrA) Mbur_1516(hdrC) Mbur_1517(hdrB)
MCJ: MCON_3279(hdrA) MCON_3282(hdrC) MCON_3283(hdrB)
MBG: BN140_0752(hdrA1) BN140_1726(hdrC) BN140_1727(hdrB) BN140_1728(hdrA3) BN140_1729(MvhD) BN140_1834(mvhG) BN140_1835(mvhA)
MEMA: MMAB1_0971(hdrA) MMAB1_2221(hdrC) MMAB1_2222(hdrB) MMAB1_2223(hdrA) MMAB1_2224(vhcD) MMAB1_2367(vhcG) MMAB1_2368(vhcA)
MPD: MCP_1576(hdrA-1) MCP_1577(hdrB-1) MCP_1578(hdrC-1) MCP_2492(mvhA-1) MCP_2493(mvhG-1) MCP_2767(mvhD-2) MCP_2768(hdrA-2) MCP_2769(hdrB-3) MCP_2770(hdrC-3) MCP_2773(mvhG-2) MCP_2774(mvhA-2)
MEZ: Mtc_0109(mvhA-1) Mtc_0111(mvhG-1) Mtc_2472(mvhD-2) Mtc_2473(hdrA-2) Mtc_2474(hdrB-2) Mtc_2475(hdrC-2) Mtc_2478(mvhG-2) Mtc_2479(mvhA-2)
RCI: RCIX473(mvhA-1) RCIX474(mvhG-1) RCIX590(mvhA-2) RCIX591(mvhG-2) RCIX594(hdrC-2) RCIX595(hdrB-2) RCIX596(hdrA-2) RCIX597(mvhD-1) RRC256(hdrC-3) RRC257(hdrB-3) RRC258(hdrA-3)
HDF: AArcSl_1855(hdrA)
MEAR: Mpt1_c02960(hdrC1) Mpt1_c02970(hdrB1) Mpt1_c08830(hdrB2) Mpt1_c08840(hdrC2) Mpt1_c10550(mvhA) Mpt1_c10560(mvhG) Mpt1_c10570(vhcD) Mpt1_c10580(hdrA)
SSO: SSO1127(hdrC-1) SSO1129(hdrB-1) SSO1131(hdrA) SSO1134(hdrC-2) SSO1135(hdrB-2)
BARC: AOA65_0030(hdrC_1) AOA65_1112(hdrA_1) AOA65_1400(hdrC_2) AOA65_1401(hdrB_2) AOA65_1402(hdrA_3) AOA65_1715(mvhD_1) AOA65_1718(mvhD_2) AOA65_1719(hdlA_2) AOA65_1722 AOA65_1723 AOA65_1885(mvhA) AOA65_1886(mvhG) AOA65_1887(hdrB_3) AOA65_1888(hdrC_3) AOA65_1889(vhcD) AOA65_1993(hdrB_4) AOA65_1994(hdrC_4) AOA65_1995(hdrA_4)
BARB: AOA66_0155(hdrA_1) AOA66_1505(mvhA_2) AOA66_1506(mvhG) AOA66_1507(hdrB_1) AOA66_1508(hdrC_1) AOA66_1509(vhcD) AOA66_1510(hdrA_2) AOA66_1511(mvhD) AOA66_1512(hdlA_2) AOA66_1513(hdrA_3) AOA66_1526(hdrA_4) AOA66_1731(hdrB_2) AOA66_1732(hdrC_2)
PSYT: DSAG12_01135(mvhD_1) DSAG12_01136(hdrA_1) DSAG12_01137(hdrB_1) DSAG12_01138(hdrC_1) DSAG12_01145(hdrC_2) DSAG12_01146(hdrB_2) DSAG12_01147(hdrA_2) DSAG12_01148(mvhD_2) DSAG12_01149(mvhG_1) DSAG12_01161(hdrB_3) DSAG12_01162(hdrC_3) DSAG12_02253(hdrA_3) DSAG12_02804(mvhD_4) DSAG12_02805(hdrA_4) DSAG12_02806(hdrC_4) DSAG12_02807(hdrB_4) DSAG12_03218(hdrC_5) DSAG12_03220(hdrA_5) DSAG12_03223(hdrB_5) DSAG12_03720(vhcD) DSAG12_03721(hdrA_6) DSAG12_03722(mvhD_5) DSAG12_03723(hdlA_4) DSAG12_03724(hdrA_7) DSAG12_03725(hdrB_6) DSAG12_03726(hdrC_6) DSAG12_03951(vhcA) DSAG12_03952(hdrB_7) DSAG12_03953(hdrC_7) DSAG12_03954(mvhG_2)
 » show all
Reference
1  [PMID:2654933]
  Authors
Reeve JN, Beckler GS, Cram DS, Hamilton PT, Brown JW, Krzycki JA, Kolodziej AF, Alex L, Orme-Johnson WH, Walsh CT
  Title
A hydrogenase-linked gene in Methanobacterium thermoautotrophicum strain delta H  encodes a polyferredoxin.
  Journal
Proc Natl Acad Sci U S A 86:3031-5 (1989)
DOI:10.1073/pnas.86.9.3031
  Sequence
Reference
2  [PMID:7925445]
  Authors
Hedderich R, Koch J, Linder D, Thauer RK
  Title
The heterodisulfide reductase from Methanobacterium thermoautotrophicum contains  sequence motifs characteristic of pyridine-nucleotide-dependent thioredoxin reductases.
  Journal
Eur J Biochem 225:253-61 (1994)
DOI:10.1111/j.1432-1033.1994.00253.x
  Sequence
Reference
3  [PMID:8119281]
  Authors
Setzke E, Hedderich R, Heiden S, Thauer RK
  Title
H2: heterodisulfide oxidoreductase complex from Methanobacterium thermoautotrophicum. Composition and properties.
  Journal
Eur J Biochem 220:139-48 (1994)
DOI:10.1111/j.1432-1033.1994.tb18608.x
Reference
4  [PMID:12856108]
  Authors
Stojanowic A, Mander GJ, Duin EC, Hedderich R
  Title
Physiological role of the F420-non-reducing hydrogenase (Mvh) from Methanothermobacter marburgensis.
  Journal
Arch Microbiol 180:194-203 (2003)
DOI:10.1007/s00203-003-0577-9
  Sequence
Reference
5  [PMID:21262829]
  Authors
Kaster AK, Moll J, Parey K, Thauer RK
  Title
Coupling of ferredoxin and heterodisulfide reduction via electron bifurcation in  hydrogenotrophic methanogenic archaea.
  Journal
Proc Natl Acad Sci U S A 108:2981-6 (2011)
DOI:10.1073/pnas.1016761108
Reference
6  [PMID:24039260]
  Authors
Costa KC, Lie TJ, Xia Q, Leigh JA
  Title
VhuD facilitates electron flow from H2 or formate to heterodisulfide reductase in Methanococcus maripaludis.
  Journal
J Bacteriol 195:5160-5 (2013)
DOI:10.1128/JB.00895-13
Other DBs
ExplorEnz - The Enzyme Database: 1.8.98.5
IUBMB Enzyme Nomenclature: 1.8.98.5
ExPASy - ENZYME nomenclature database: 1.8.98.5
BRENDA, the Enzyme Database: 1.8.98.5

KEGG   REACTION: R11943
Entry
R11943                      Reaction                               

Name
CoB,CoM,ferredoxin:H2 oxidoreductase
Definition
Coenzyme B + Coenzyme M + 2 Reduced ferredoxin + 2 H+ <=> Coenzyme M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide + 2 Oxidized ferredoxin + 2 Hydrogen
Equation
C04628 + C03576 + 2 C00138 + 2 C00080 <=> C04832 + 2 C00139 + 2 C00282
Reaction class
RC00011  C03576_C04832  C04628_C04832
Enzyme
Pathway
rn00680  Methane metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Orthology
K03388  heterodisulfide reductase subunit A2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]
K03389  heterodisulfide reductase subunit B2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]
K03390  heterodisulfide reductase subunit C2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]
K14126  F420-non-reducing hydrogenase large subunit [EC:1.12.99.- 1.8.98.5]
K14127  F420-non-reducing hydrogenase iron-sulfur subunit [EC:1.12.99.- 1.8.98.5 1.8.98.6]
K14128  F420-non-reducing hydrogenase small subunit [EC:1.12.99.- 1.8.98.5]
Other DBs
RHEA: 55755

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