KEGG   ORTHOLOGY: K03388
Entry
K03388                      KO                                     

Name
hdrA2
Definition
heterodisulfide reductase subunit A2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K03388  hdrA2; heterodisulfide reductase subunit A2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.7  With an iron-sulfur protein as acceptor
    1.8.7.3  ferredoxin:CoB-CoM heterodisulfide reductase
     K03388  hdrA2; heterodisulfide reductase subunit A2
   1.8.98  With other, known, physiological acceptors
    1.8.98.4  coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase
     K03388  hdrA2; heterodisulfide reductase subunit A2
    1.8.98.5  H2:CoB-CoM heterodisulfide,ferredoxin reductase
     K03388  hdrA2; heterodisulfide reductase subunit A2
    1.8.98.6  formate:CoB-CoM heterodisulfide,ferredoxin reductase
     K03388  hdrA2; heterodisulfide reductase subunit A2
Other DBs
RN: R11928 R11931 R11943 R11944
COG: COG1148
Genes
TMB: Thimo_0253
HHC: M911_11230
EBS: ECTOBSL9_0285
TGR: Tgr7_2214
TKM: TK90_0634
TNI: TVNIR_3247(hdrA_[H])
TVR: TVD_10640
APRS: BI364_13805
ACII: C4901_12970
CBX: Cenrod_2147(hdrA)
SPLB: SFPGR_29450(hdrA)
SNIV: SFSGTM_27290(hdrA)
SLAC: SKTS_06230(hdrA-2)
GSU: GSU0090(hdrA)
GSK: KN400_0065(hdrA)
GME: Gmet_2084(bamE) Gmet_3426(hdrA)
GLO: Glov_0864
GBM: Gbem_0030(hdrA) Gbem_1447(bamE)
GEO: Geob_0215(bamE-1) Geob_0231(bamE-2) Geob_3723(hdrA)
DVU: DVU2402(hdrA)
DVL: Dvul_0828
DVM: DvMF_0324
DDS: Ddes_2100
DMA: DMR_01920(hdrA) DMR_22120
DGG: DGI_1050(hdrA)
DTR: RSDT_0567(hdrA)
DHY: DESAM_21330(hdrA)
DPI: BN4_11860(hdrA)
DPS: DP1010
DOL: Dole_1159
DML: Dmul_02770(hdrA1) Dmul_24500(bamE) Dmul_28860(hdrA2)
DAT: HRM2_06460 HRM2_11710(hdrA1) HRM2_11850(hdrA2) HRM2_14330(hdrA3) HRM2_14340(hdrA3') HRM2_22750(hdrA4)
DTO: TOL2_C03750(bamE1) TOL2_C11590(hdlA2) TOL2_C11630(hdlA3?) TOL2_C17900(hdlA5) TOL2_C24180(hdlA6) TOL2_C25730(hdlA7) TOL2_C28760(hdlA8) TOL2_C28830(hdlA9) TOL2_C41400(bamE2) TOL2_C43540(bamE3)
ADE: Adeh_4164
HDN: Hden_0691
BLAG: BLTE_14930(hdrA-2)
RHC: RGUI_1281
AFR: AFE_2553
ATX: GCD22_03148(hdrA) GCD22_03279(hdrA)
BTS: Btus_2496
RCH: RUM_10980
BPRO: PMF13cell1_01672(ndhI_2)
SWO: Swol_0397
SALQ: SYNTR_0264
PTH: PTH_1410(HdrA)
SGY: Sgly_1900
HMO: HM1_2008(hdrA)
SAY: TPY_3529(hdrA)
MTA: Moth_1453
MTHZ: MOTHA_c08510(ndhI3) MOTHA_c15280(mnmC2)
STED: SPTER_13760(mnmC)
AFO: Afer_0966
DFO: Dform_00920(hdrA) Dform_00941(hdrA)
TRO: trd_0153
OTE: Oter_3677
APS: CFPG_240
AFD: Alfi_2101
ASH: AL1_26630
BACC: BRDCF_p1060 BRDCF_p823(hdrA) BRDCF_p824(hdrA2)
CTE: CT1246(hdrA-2)
CPC: Cpar_0949
CCH: Cag_1029
CLI: Clim_1200
PVI: Cvib_0843
PLT: Plut_1109
PPH: Ppha_1306
CTS: Ctha_0136
AAE: aq_395(hdrA)
HTH: HTH_1881(hdrA)
TAL: Thal_1346
CABY: Cabys_1917
CTHI: THC_1756
BANA: BARAN1_0338(hdrA)
MMP: MMP0825(hdrA) MMP1697(hdrA)
MMD: GYY_04785
MMAK: MMKA1_09100(hdrA) MMKA1_19310(hdrA)
MMAO: MMOS7_08880(hdrA) MMOS7_18120(hdrA)
MMAD: MMJJ_01720(hdrA) MMJJ_11320(hdrA2)
MTH: MTH_1381
MMG: MTBMA_c17680(hdrA)
METC: MTCT_1255
MWO: MWSIV6_1762(hdrA)
METE: tca_01335(rsxB_2)
MST: Msp_1476(hdrA1)
MRU: mru_0117(hdrA)
MSI: Msm_1336
MEB: Abm4_1691(hdrA2)
MMIL: sm9_2251(hdrA2)
MEYE: TL18_00375
MOL: YLM1_1554
METH: MBMB1_1958(hdrA)
MFC: BRM9_2298(hdrA2)
MFI: DSM1535_1232(hdrA)
MCUB: MCBB_2243(hdrA3)
MFV: Mfer_0184
MKA: MK0249(hdrA_1) MK0265(hdrA_2)
MBAR: MSBR2_0910
MBAK: MSBR3_0798
MAC: MA_2868(hdrA)
MMA: MM_0056
METM: MSMTP_1469
MTHR: MSTHT_0375
MTHE: MSTHC_0346
MBU: Mbur_0552(hdrA)
MMET: MCMEM_1365
MMH: Mmah_0955
MTP: Mthe_1576
MCJ: MCON_3279(hdrA)
MHI: Mhar_0607
MBG: BN140_0752(hdrA1) BN140_1728(hdrA3)
MEMA: MMAB1_0971(hdrA) MMAB1_2223(hdrA)
MPD: MCP_1576(hdrA-1) MCP_2768(hdrA-2)
MEZ: Mtc_2473(hdrA-2)
RCI: RCIX596(hdrA-2) RRC258(hdrA-3)
HDF: AArcSl_1855(hdrA)
MEAR: Mpt1_c10580(hdrA)
MARC: AR505_1479
ABI: Aboo_0977
STO: STK_18730
SSO: SSO1131(hdrA)
SOL: Ssol_2101
SSOA: SULA_2132
SSOL: SULB_2133
SSOF: SULC_2131
SAI: Saci_0328(hdrA)
SID: M164_1089
SII: LD85_1217
SIH: SiH_1060
SIR: SiRe_0973
SIC: SiL_0979
MSE: Msed_1545
MCN: Mcup_0686
AHO: Ahos_1694
STEP: IC006_0777
BARC: AOA65_1112(hdrA_1) AOA65_1402(hdrA_3) AOA65_1719(hdlA_2) AOA65_1995(hdrA_4)
BARB: AOA66_0155(hdrA_1) AOA66_1510(hdrA_2) AOA66_1512(hdlA_2) AOA66_1513(hdrA_3) AOA66_1526(hdrA_4)
LOKI: Lokiarch_00290(hdrA_1) Lokiarch_01240(hdrA_2) Lokiarch_08680(hdrA_4) Lokiarch_09900(hdrA_5) Lokiarch_10040(hdlA_3) Lokiarch_17940(hdlA_5) Lokiarch_23600(hdrA_8) Lokiarch_25880(hdrA_9) Lokiarch_28050(hdrA_10) Lokiarch_40200(hdrA_13) Lokiarch_41160(hdrA_15) Lokiarch_49330(hdrA_16)
PSYT: DSAG12_01136(hdrA_1) DSAG12_01147(hdrA_2) DSAG12_02253(hdrA_3) DSAG12_02805(hdrA_4) DSAG12_03220(hdrA_5) DSAG12_03721(hdrA_6) DSAG12_03723(hdlA_4) DSAG12_03724(hdrA_7)
 » show all
Reference
PMID:2121478
  Authors
Hedderich R, Berkessel A, Thauer RK
  Title
Purification and properties of heterodisulfide reductase from Methanobacterium thermoautotrophicum (strain Marburg).
  Journal
Eur J Biochem 193:255-61 (1990)
DOI:10.1111/j.1432-1033.1990.tb19331.x
  Sequence
Reference
PMID:8119281
  Authors
Setzke E, Hedderich R, Heiden S, Thauer RK
  Title
H2: heterodisulfide oxidoreductase complex from Methanobacterium thermoautotrophicum. Composition and properties.
  Journal
Eur J Biochem 220:139-48 (1994)
DOI:10.1111/j.1432-1033.1994.tb18608.x
  Sequence
Reference
  Authors
Mander GJ, Pierik AJ, Huber H, Hedderich R
  Title
Two distinct heterodisulfide reductase-like enzymes in the sulfate-reducing archaeon Archaeoglobus profundus.
  Journal
Eur J Biochem 271:1106-16 (2004)
DOI:10.1111/j.1432-1033.2004.04013.x
  Sequence
[apo:Arcpr_1555] [afu:AF_1377]

KEGG   ORTHOLOGY: K03389
Entry
K03389                      KO                                     

Name
hdrB2
Definition
heterodisulfide reductase subunit B2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K03389  hdrB2; heterodisulfide reductase subunit B2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.7  With an iron-sulfur protein as acceptor
    1.8.7.3  ferredoxin:CoB-CoM heterodisulfide reductase
     K03389  hdrB2; heterodisulfide reductase subunit B2
   1.8.98  With other, known, physiological acceptors
    1.8.98.4  coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase
     K03389  hdrB2; heterodisulfide reductase subunit B2
    1.8.98.5  H2:CoB-CoM heterodisulfide,ferredoxin reductase
     K03389  hdrB2; heterodisulfide reductase subunit B2
    1.8.98.6  formate:CoB-CoM heterodisulfide,ferredoxin reductase
     K03389  hdrB2; heterodisulfide reductase subunit B2
Other DBs
RN: R11928 R11931 R11943 R11944
COG: COG2048
Genes
TIG: THII_2280
THIS: HZT40_21385
TVI: Thivi_3111
TMB: Thimo_0248
TSY: THSYN_16425
HHC: M911_11215 M911_11235
EBS: ECTOBSL9_0282 ECTOBSL9_0286
TGR: Tgr7_2211 Tgr7_2215
TKM: TK90_0633 TK90_0637
TNI: TVNIR_3244(hdrB_[H]) TVNIR_3248(hdlB_[H])
SLIM: SCL_2520
TBN: TBH_C2777
ENM: EBS_2145(hdrB)
SHD: SUTH_02769(hdrB)
TBD: Tbd_1645
SDR: SCD_n01881(hdrB)
SLAC: SKTS_06180(hdrB) SKTS_11890
GSU: GSU0091(hdrB)
GSK: KN400_0066(hdrB)
GME: Gmet_3425(hdrB)
GLO: Glov_0862
GBM: Gbem_0031(hdrB)
GEO: Geob_3724(hdrB)
GEM: GM21_0030
GBN: GEOBRER4_00290(hdrB)
DVU: DVU2403(hdrB)
DVL: Dvul_0827
DVM: DvMF_0323
DDS: Ddes_2099
DMA: DMR_01910(hdrB)
DGG: DGI_1049(hdrB)
DTR: RSDT_0566(hdrB)
DAS: Daes_0784
DPI: BN4_11859(hdrB)
DOL: Dole_1160
DML: Dmul_28870(hdrB)
DAT: HRM2_22770(hdrD2')
SFU: Sfum_0819
BLAG: BLTE_14980
ATX: GCD22_01577(hdrB1) GCD22_02661(hdrB1) GCD22_03145(hdrB) GCD22_03149(hdrB1) GCD22_03192(hdrB1)
RCH: RUM_10960
RUM: CK1_05040
BPRO: PMF13cell1_01670(lutA)
SWO: Swol_0395
SALQ: SYNTR_0262
PTH: PTH_1412(HdrB)
SGY: Sgly_1901
HMO: HM1_2007
HCV: FTV88_1703(hdrB)
CHY: CHY_0929
ADG: Adeg_1334
TACI: TDSAC_1307
STED: SPTER_13750(sdhE_1)
DFO: Dform_00942(hdrB)
OTE: Oter_3676
TTF: THTE_4308
APS: CFPG_239
AFD: Alfi_2100
CTE: CT1245
CPC: Cpar_0950
CCH: Cag_1028
CLI: Clim_1201
PVI: Cvib_0844
PLT: Plut_1108
PPH: Ppha_1307
AAE: aq_400(hdrB)
HTH: HTH_1878(hdrB1) HTH_1882(hdrB2)
TTK: TST_1519(hdrB)
CABY: Cabys_1918
MMP: MMP1053(hdrB2) MMP1155(hdrB1)
MMAK: MMKA1_12180(hdrB) MMKA1_13330(hdrB)
MMAO: MMOS7_11480(hdrB) MMOS7_12630(hdrB)
MMAD: MMJJ_16900 MMJJ_17970(lutA)
MAE: Maeo_0308
METF: CFE53_06410(hdrB)
MTH: MTH_1879
MMG: MTBMA_c04500(hdrB)
METC: MTCT_1717
MWO: MWSIV6_0410(hdrB)
METE: tca_01815(lutA)
METK: FVF72_02310(hdrB)
MTHM: FZP57_01925(hdrB)
MST: Msp_1013(hdrB1)
MRU: mru_0817(hdrB1)
MSI: Msm_0795
MEB: Abm4_1308(hdrB2)
MMIL: sm9_1716(hdrB3)
MEYE: TL18_07635
MOL: YLM1_0405
METH: MBMB1_1274(hdrB)
MFC: BRM9_0490(hdrB1)
MFI: DSM1535_0471(hdrB)
MCUB: MCBB_1489(hdrB3)
METT: CIT01_08470(hdrB)
METO: CIT02_11685(hdrB)
MFV: Mfer_0739
MKA: MK0572(hdrB)
AFU: AF_1375
MBAR: MSBR2_3160
MBAK: MSBR3_3156
MAC: MA_4237(hdrB)
METM: MSMTP_0364
MTHR: MSTHT_1573
MTHE: MSTHC_1716
MFZ: AOB57_006960(hdrB)
MBU: Mbur_1517(hdrB)
MMET: MCMEM_1990
MMH: Mmah_1786
MZI: HWN40_01880(hdrB)
MTP: Mthe_1573
MCJ: MCON_3283(hdrB)
MHI: Mhar_0604
MHU: Mhun_1837
MLA: Mlab_0240
MBG: BN140_1727(hdrB)
MEMA: MMAB1_2222(hdrB)
MBN: Mboo_0589
MPL: Mpal_2240
MPD: MCP_1577(hdrB-1) MCP_2769(hdrB-3)
MEZ: Mtc_2474(hdrB-2)
RCI: RCIX595(hdrB-2) RRC257(hdrB-3)
MEAR: Mpt1_c02970(hdrB1) Mpt1_c08830(hdrB2)
MARC: AR505_0274
ABI: Aboo_0976
SSO: SSO1129(hdrB-1) SSO1135(hdrB-2)
SAI: Saci_0325(hdrB) Saci_0329
KCR: Kcr_0767
BARC: AOA65_1401(hdrB_2) AOA65_1887(hdrB_3) AOA65_1993(hdrB_4)
BARB: AOA66_1507(hdrB_1) AOA66_1731(hdrB_2)
LOKI: Lokiarch_01260(hdrB_1) Lokiarch_23590(hdrB_2) Lokiarch_39150(hdrB_3) Lokiarch_45510(hdrB_4)
PSYT: DSAG12_01137(hdrB_1) DSAG12_01146(hdrB_2) DSAG12_01161(hdrB_3) DSAG12_02807(hdrB_4) DSAG12_03223(hdrB_5) DSAG12_03725(hdrB_6) DSAG12_03952(hdrB_7)
 » show all
Reference
PMID:2121478
  Authors
Hedderich R, Berkessel A, Thauer RK
  Title
Purification and properties of heterodisulfide reductase from Methanobacterium thermoautotrophicum (strain Marburg).
  Journal
Eur J Biochem 193:255-61 (1990)
DOI:10.1111/j.1432-1033.1990.tb19331.x
  Sequence
Reference
PMID:8119281
  Authors
Setzke E, Hedderich R, Heiden S, Thauer RK
  Title
H2: heterodisulfide oxidoreductase complex from Methanobacterium thermoautotrophicum. Composition and properties.
  Journal
Eur J Biochem 220:139-48 (1994)
DOI:10.1111/j.1432-1033.1994.tb18608.x
  Sequence
Reference
  Authors
Mander GJ, Pierik AJ, Huber H, Hedderich R
  Title
Two distinct heterodisulfide reductase-like enzymes in the sulfate-reducing archaeon Archaeoglobus profundus.
  Journal
Eur J Biochem 271:1106-16 (2004)
DOI:10.1111/j.1432-1033.2004.04013.x
  Sequence
[apo:Arcpr_1553] [afu:AF_1375]

KEGG   ORTHOLOGY: K03390
Entry
K03390                      KO                                     

Name
hdrC2
Definition
heterodisulfide reductase subunit C2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K03390  hdrC2; heterodisulfide reductase subunit C2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.7  With an iron-sulfur protein as acceptor
    1.8.7.3  ferredoxin:CoB-CoM heterodisulfide reductase
     K03390  hdrC2; heterodisulfide reductase subunit C2
   1.8.98  With other, known, physiological acceptors
    1.8.98.4  coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase
     K03390  hdrC2; heterodisulfide reductase subunit C2
    1.8.98.5  H2:CoB-CoM heterodisulfide,ferredoxin reductase
     K03390  hdrC2; heterodisulfide reductase subunit C2
    1.8.98.6  formate:CoB-CoM heterodisulfide,ferredoxin reductase
     K03390  hdrC2; heterodisulfide reductase subunit C2
Other DBs
RN: R11928 R11931 R11943 R11944
COG: COG1150
Genes
TMB: Thimo_0247
HHC: M911_11220
EBS: ECTOBSL9_0283
TGR: Tgr7_2212
TKM: TK90_0636
TNI: TVNIR_3245(hdlC_[H])
TVR: TVD_10630
APRS: BI364_13795
ACII: C4901_12960
SULF: CAP31_01860
SPLB: SFPGR_29430(hdrC)
SNIV: SFSGTM_27270(hdrC)
SLAC: SKTS_06170
GSU: GSU0092(hdrC)
GSK: KN400_0067(hdrC)
GME: Gmet_3424(hdrC)
GLO: Glov_0861
GBM: Gbem_0032(hdrC)
GEO: Geob_3725(hdrC)
GEM: GM21_0031
GBN: GEOBRER4_00300(hdrC)
DVU: DVU2404(hdrC)
DVL: Dvul_0826
DVM: DvMF_0322
DDS: Ddes_2098
DMA: DMR_01900(hdrC)
DGG: DGI_1048(hdrC)
DTR: RSDT_0565(hdrC)
DAS: Daes_0783
DPI: BN4_11858(hdrC)
DSF: UWK_01755
DOL: Dole_1161
DML: Dmul_28880(hdrC)
DAT: HRM2_22760(hdrD2)
DTO: TOL2_C17910(hdlC)
SFU: Sfum_0820
DBR: Deba_2022
HDN: Hden_0693
BLAG: BLTE_14840
RHC: RGUI_1279
AFR: AFE_2551
ACU: Atc_2348
ATX: GCD22_03146(hdlC)
RCH: RUM_10970
RUM: CK1_05050
BPRO: PMF13cell1_01671(rsxC_1)
SWO: Swol_0394
SLP: Slip_2075
SALQ: SYNTR_0261
PTH: PTH_1413(GlpC)
DAU: Daud_0563
SGY: Sgly_1902
HMO: HM1_2006
CHY: CHY_0927
DFO: Dform_00943(hdrC)
APS: CFPG_238
AAE: aq_391 aq_398(hdrC)
HTH: HTH_1879(hdrC1) HTH_1883(hdrC2)
TTK: TST_1518(hdrC)
BANA: BARAN1_0333(hdrC)
MMP: MMP1054(hdrC2) MMP1154(hdrC1)
MMAK: MMKA1_12190(hdrC) MMKA1_13320(hdrC)
MMAO: MMOS7_11490(hdrC) MMOS7_12620(hdrC)
MAE: Maeo_0307
METF: CFE53_02215(hdrC) CFE53_06415(hdrC)
MTH: MTH_1878
MMG: MTBMA_c04490(hdrC)
METC: MTCT_1716
MWO: MWSIV6_0409(hdrC)
METE: tca_01814
METK: FVF72_02315(hdrC)
MTHM: FZP57_01920(hdrC)
MST: Msp_1014(hdrC1)
MRU: mru_0816(hdrC)
MSI: Msm_0796
MEB: Abm4_1309(hdrC2)
MMIL: sm9_1717(hdrC2)
MEYE: TL18_07640
MOL: YLM1_0404
METH: MBMB1_1275
MFC: BRM9_0491(hdrC1)
MFI: DSM1535_0472(hdrC)
MCUB: MCBB_1490(hdrC3)
METT: CIT01_08465(hdrC)
METO: CIT02_11680(hdrC)
MFV: Mfer_0740
MKA: MK0573(hdrC)
AFU: AF_1376
GAH: GAH_01704
MBAR: MSBR2_3161
MBAK: MSBR3_3157
MAC: MA_4236(hdrC)
MMA: MM_0979
METM: MSMTP_0365
MTHR: MSTHT_1572
MTHE: MSTHC_1717
MFZ: AOB57_006955(hdrC)
MBU: Mbur_1516(hdrC)
MMET: MCMEM_1991
MMH: Mmah_1787
MZI: HWN40_01885(hdrC)
MTP: Mthe_1574
MCJ: MCON_3282(hdrC)
MHI: Mhar_0605
MHU: Mhun_1836
MLA: Mlab_0239
MBG: BN140_1726(hdrC)
MEMA: MMAB1_2221(hdrC)
MBN: Mboo_0590
MPL: Mpal_2241
MPD: MCP_1578(hdrC-1) MCP_2770(hdrC-3)
MEZ: Mtc_2475(hdrC-2)
RCI: RCIX594(hdrC-2) RRC256(hdrC-3)
MEAR: Mpt1_c02960(hdrC1) Mpt1_c08840(hdrC2)
MARC: AR505_0273
ABI: Aboo_0975
SSO: SSO1127(hdrC-1) SSO1134(hdrC-2)
SAI: Saci_0326 Saci_0334(hdrC)
VDI: Vdis_0690
VMO: VMUT_2339
KCR: Kcr_0766
BARC: AOA65_0030(hdrC_1) AOA65_1400(hdrC_2) AOA65_1888(hdrC_3) AOA65_1994(hdrC_4)
BARB: AOA66_1508(hdrC_1) AOA66_1732(hdrC_2)
LOKI: Lokiarch_01250(hdrC_1) Lokiarch_03060(hdrC_2) Lokiarch_23580(hdrC_3) Lokiarch_23870(hdrC_4) Lokiarch_39160(hdrC_5) Lokiarch_45500(hdrC_6)
PSYT: DSAG12_01138(hdrC_1) DSAG12_01145(hdrC_2) DSAG12_01162(hdrC_3) DSAG12_02806(hdrC_4) DSAG12_03218(hdrC_5) DSAG12_03726(hdrC_6) DSAG12_03953(hdrC_7)
 » show all
Reference
PMID:2121478
  Authors
Hedderich R, Berkessel A, Thauer RK
  Title
Purification and properties of heterodisulfide reductase from Methanobacterium thermoautotrophicum (strain Marburg).
  Journal
Eur J Biochem 193:255-61 (1990)
DOI:10.1111/j.1432-1033.1990.tb19331.x
  Sequence
Reference
PMID:8119281
  Authors
Setzke E, Hedderich R, Heiden S, Thauer RK
  Title
H2: heterodisulfide oxidoreductase complex from Methanobacterium thermoautotrophicum. Composition and properties.
  Journal
Eur J Biochem 220:139-48 (1994)
DOI:10.1111/j.1432-1033.1994.tb18608.x
  Sequence
Reference
  Authors
Mander GJ, Pierik AJ, Huber H, Hedderich R
  Title
Two distinct heterodisulfide reductase-like enzymes in the sulfate-reducing archaeon Archaeoglobus profundus.
  Journal
Eur J Biochem 271:1106-16 (2004)
DOI:10.1111/j.1432-1033.2004.04013.x
  Sequence

KEGG   ORTHOLOGY: K14127
Entry
K14127                      KO                                     

Name
mvhD, vhuD, vhcD
Definition
F420-non-reducing hydrogenase iron-sulfur subunit [EC:1.12.99.- 1.8.98.5 1.8.98.6]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K14127  mvhD, vhuD, vhcD; F420-non-reducing hydrogenase iron-sulfur subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.98  With other, known, physiological acceptors
    1.8.98.5  H2:CoB-CoM heterodisulfide,ferredoxin reductase
     K14127  mvhD, vhuD, vhcD; F420-non-reducing hydrogenase iron-sulfur subunit
    1.8.98.6  formate:CoB-CoM heterodisulfide,ferredoxin reductase
     K14127  mvhD, vhuD, vhcD; F420-non-reducing hydrogenase iron-sulfur subunit
  1.12  Acting on hydrogen as donor
   1.12.99  With unknown physiological acceptors
    1.12.99.-  
     K14127  mvhD, vhuD, vhcD; F420-non-reducing hydrogenase iron-sulfur subunit
Other DBs
RN: R00019 R11943 R11944
COG: COG1908
Genes
TMB: Thimo_0254
CBX: Cenrod_2148(mvhD)
SLAC: SKTS_06250
GSK: KN400_0064(hdrG)
GME: Gmet_2083(bamF)
GUR: Gura_0148 Gura_3584
GLO: Glov_0865
GBM: Gbem_1448(bamF)
GEO: Geob_0216(bamF-1) Geob_0232(bamF-2) Geob_3721(hdrG)
GEM: GM21_2806
DMA: DMR_01930
DGG: DGI_1051(floxD)
DHY: DESAM_21329(vhcD)
DAS: Daes_0780
DPI: BN4_11861(mvhD)
DBA: Dbac_0851
DPS: DP1011
DOL: Dole_1158
DML: Dmul_28840(mvhD2)
DAT: HRM2_11720(mvhD2) HRM2_11860(mvhD3) HRM2_14350(mvhD4) HRM2_30880(mvhD7)
DTO: TOL2_C03740(bamF1) TOL2_C09050(mvhD1) TOL2_C11600(mvhD2) TOL2_C11640(mvhD3) TOL2_C17880(mvhD4) TOL2_C24190(mvhD5) TOL2_C25720(mvhD6) TOL2_C28770(mvhD7) TOL2_C28840(mvhD8) TOL2_C32340 TOL2_C33290(mvhD9) TOL2_C43530(bamF3)
BLAG: BLTE_14920(hdrG)
RCH: RUM_10990
RUM: CK1_05070
SWO: Swol_0398
SALQ: SYNTR_0265
DAE: Dtox_1354
PTH: PTH_1409(FrhD)
SGY: Sgly_1899
HCV: FTV88_1705(mvhD)
DFO: Dform_00940(mvhD|vhcD)
OTE: Oter_3678
TTF: THTE_4311
APS: CFPG_241
BACC: BRDCF_p825
MBAS: ALGA_3489
CPC: Cpar_0948
CCH: Cag_1030
CLI: Clim_1199
PVI: Cvib_0842
PLT: Plut_1110
PPH: Ppha_1305
CABY: Cabys_1916
TYE: THEYE_A1367(vhuD)
CTHI: THC_1757
BANA: BARAN1_0337(mvhD)
MMP: MMP0821(vhcD) MMP1696(vhuD)
MMAK: MMKA1_09060(vhcD) MMKA1_19300(vhuD)
MMAO: MMOS7_08840(vhcD) MMOS7_18110(vhuD)
MMAD: MMJJ_01760(vhcD) MMJJ_11330(vhuD)
MWO: MWSIV6_1528(mvhD) MWSIV6_1530(vhcD)
MST: Msp_0314(mvhD1) Msp_0638(mvhD2)
MRU: mru_1908(mvhD1) mru_2076(mvhD2)
MEB: Abm4_0853(mvhD2) Abm4_1512(mvhD)
MMIL: sm9_1348(flpD) sm9_2013(mvhD)
METH: MBMB1_1663(mvhD)
MFC: BRM9_0915(mvhD)
MFI: DSM1535_0883(mvhD)
MCUB: MCBB_1968(mvhD) MCBB_2030(vhcD)
MKA: MK0268(flpD_1) MK0627(flpD_2)
AFU: AF_1374
FPL: Ferp_0839
GAC: GACE_0709
GAH: GAH_02036
MMAC: MSMAC_2580
MHOR: MSHOH_1796
MPY: Mpsy_2942
MHU: Mhun_1839
MBG: BN140_1729(MvhD)
MEMA: MMAB1_2224(vhcD)
MPI: Mpet_2476
MPD: MCP_2767(mvhD-2)
MEZ: Mtc_2472(mvhD-2)
RCI: RCIX597(mvhD-1)
MEAR: Mpt1_c10570(vhcD)
MARC: AR505_1478
VMO: VMUT_2343
KCR: Kcr_1117
BARC: AOA65_1715(mvhD_1) AOA65_1718(mvhD_2) AOA65_1889(vhcD)
BARB: AOA66_1509(vhcD) AOA66_1511(mvhD)
LOKI: Lokiarch_25870(mvhD_2)
PSYT: DSAG12_01135(mvhD_1) DSAG12_01148(mvhD_2) DSAG12_02804(mvhD_4) DSAG12_03720(vhcD) DSAG12_03722(mvhD_5)
 » show all
Reference
  Authors
Stojanowic A, Mander GJ, Duin EC, Hedderich R
  Title
Physiological role of the F420-non-reducing hydrogenase (Mvh) from Methanothermobacter marburgensis.
  Journal
Arch Microbiol 180:194-203 (2003)
DOI:10.1007/s00203-003-0577-9
  Sequence

KEGG   ORTHOLOGY: K22516
Entry
K22516                      KO                                     

Name
fdhA
Definition
formate dehydrogenase (coenzyme F420) alpha subunit [EC:1.17.98.3 1.8.98.6]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K22516  fdhA; formate dehydrogenase (coenzyme F420) alpha subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.98  With other, known, physiological acceptors
    1.8.98.6  formate:CoB-CoM heterodisulfide,ferredoxin reductase
     K22516  fdhA; formate dehydrogenase (coenzyme F420) alpha subunit
  1.17  Acting on CH or CH2 groups
   1.17.98  With other, known, physiological acceptors
    1.17.98.3  formate dehydrogenase (coenzyme F420)
     K22516  fdhA; formate dehydrogenase (coenzyme F420) alpha subunit
Other DBs
RN: R10797 R11944
COG: COG3383
GO: 0043794
Genes
VNA: PN96_21155
VEJ: VEJY3_20411
PGB: H744_1c0419
PSH: Psest_3905
PSTU: UIB01_19765
PCH: EY04_14750
PSED: DM292_16890
GNI: GNIT_2862
CHIZ: HQ393_09255
CFON: HZU75_11945
CCO: CCC13826_0200(fdhH)
CCOC: CCON33237_0536(fdhH)
CGRA: CGRAC_1361(fdhH)
CPIN: CPIN18020_0262(fdhH)
CGEO: CGEO_1649(fdhH)
CMUC: CMCT_1635(fdhH)
AHS: AHALO_1025(fdhH)
AMAR: AMRN_1963(fdhH)
ACAA: ACAN_2017(fdhH)
SULJ: SJPD1_1032
GEO: Geob_0149
PCA: Pcar_2701
DSF: UWK_03159
DAT: HRM2_11880(fdhA3) HRM2_14370(fdhA4)
EFS: EFS1_1216
ENE: ENT_08450
CSQ: CSCA_0253
DSY: DSY1990
DHD: Dhaf_3153
SFI: SFUL_466
MJA: MJ_0006
MMP: MMP0138(fdhA) MMP1298(fdhA)
MMAK: MMKA1_01430(fdhA) MMKA1_15230(fdhA)
MMAO: MMOS7_01690(fdhA) MMOS7_14050(fdhA)
MMAD: MMJJ_09470(fdhF_2) MMJJ_15440(fdhA2)
MAE: Maeo_0578
MTH: MTH_1140
MMG: MTBMA_c15230(fdhA2)
METE: tca_01096
MST: Msp_0640(fdhA)
MRU: mru_0333(fdhA1) mru_2074(fdhA2)
MEB: Abm4_0131(fdhA) Abm4_0855(fdhA2)
MMIL: sm9_1350(flpA) sm9_2183(fdhA)
MEYE: TL18_01670
METH: MBMB1_0104(fdhA)
MFC: BRM9_0168(fdhA)
MFI: DSM1535_1486(fdhA)
MCUB: MCBB_2028(fdhA)
MKA: MK0321
FPL: Ferp_0094
PYN: PNA2_1925
PYS: Py04_1234
TKO: TK2076
TGA: TGAM_0065(mhy2A) TGAM_0249(fdh1A) TGAM_0631(fdhA)
TSI: TSIB_0067
PPAC: PAP_03230
MBAR: MSBR2_2855
MMAC: MSMAC_2582
METM: MSMTP_1177
MHOR: MSHOH_1794
MPY: Mpsy_2944
MTP: Mthe_1339
MCJ: MCON_2237(fdhA)
MBG: BN140_0842(fdhA) BN140_1327(fdhA1) BN140_1329(fdhA2) BN140_2198(fdhA3)
MEMA: MMAB1_1106(fdhA) MMAB1_1689(fdhA) MMAB1_2914(fdhA)
MBN: Mboo_0923
MPD: MCP_1570(fdhA-1) MCP_2407(fdhA-2)
MEZ: Mtc_2125(fdhA)
RCI: RCIX1628(fdhA-1) RCIX2373(fdhA-2) RCIX2378(fdhA-3) RRC251(fdhA-4)
HHB: Hhub_2705(fdhA)
HALH: HTSR_1736(fdhA) HTSR_1740(fdhA2)
HHSR: HSR6_1802(fdoG2) HSR6_1806(fdoG3)
HHI: HAH_5041(fdhA)
NMO: Nmlp_2714(fdhA)
HLA: Hlac_1238
HALQ: Hrr1229_013155(fdhF)
HALU: HUG12_20610(fdhF)
HDF: AArcSl_0465(fdoG) AArcSl_1489(fdoG2)
HTU: Htur_0685
HALY: HYG82_00570(fdhF)
TAC: Ta0045
TVO: TVG0003442(TVG0003442)
FAI: FAD_1471
ABI: Aboo_0808
IHO: Igni_1101
IIS: EYM_07315
MSE: Msed_1457
AHO: Ahos_2012
VDI: Vdis_2449
TPE: Tpen_0190
 » show all
Reference
  Authors
Lupa B, Hendrickson EL, Leigh JA, Whitman WB
  Title
Formate-dependent H2 production by the mesophilic methanogen Methanococcus maripaludis.
  Journal
Appl Environ Microbiol 74:6584-90 (2008)
DOI:10.1128/AEM.01455-08
Reference
  Authors
Costa KC, Lie TJ, Xia Q, Leigh JA
  Title
VhuD facilitates electron flow from H2 or formate to heterodisulfide reductase in Methanococcus maripaludis.
  Journal
J Bacteriol 195:5160-5 (2013)
DOI:10.1128/JB.00895-13

KEGG   ORTHOLOGY: K00125
Entry
K00125                      KO                                     

Name
fdhB
Definition
formate dehydrogenase (coenzyme F420) beta subunit [EC:1.17.98.3 1.8.98.6]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K00125  fdhB; formate dehydrogenase (coenzyme F420) beta subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.98  With other, known, physiological acceptors
    1.8.98.6  formate:CoB-CoM heterodisulfide,ferredoxin reductase
     K00125  fdhB; formate dehydrogenase (coenzyme F420) beta subunit
  1.17  Acting on CH or CH2 groups
   1.17.98  With other, known, physiological acceptors
    1.17.98.3  formate dehydrogenase (coenzyme F420)
     K00125  fdhB; formate dehydrogenase (coenzyme F420) beta subunit
Other DBs
RN: R10797 R11944
COG: COG1035 COG1139
GO: 0043794
Genes
TMB: Thimo_0255
SLAC: SKTS_06260
DDE: Dde_1211 Dde_3528
DMA: DMR_01940
DGG: DGI_1052(floxC)
DFL: DFE_0758 DFE_2489
DCB: C3Y92_00575
DMS: E8L03_02850
DSD: GD606_00175 GD606_07840 GD606_11690
DSA: Desal_0598
DAS: Daes_0781
DPI: BN4_11862
DBA: Dbac_2346
DRT: Dret_0419
DAL: Dalk_5062
DAT: HRM2_22740(fdhB6)
DBR: Deba_2134
BLAG: BLTE_14910
RCH: RUM_11000
RUM: CK1_05080
SWO: Swol_0400
SALQ: SYNTR_0266
PTH: PTH_1407(RnfC)
DAU: Daud_0567
SGY: Sgly_1898
HMO: HM1_2010
CTHM: CFE_1626
CHY: CHY_0932
ADG: Adeg_1331
MJA: MJ_0005
MMP: MMP0139(fdhB) MMP1297(fdhB)
MMAK: MMKA1_01440(fdhB) MMKA1_15220(fdhB)
MMAO: MMOS7_01700(fdhB) MMOS7_14040(fdhB)
MMAD: MMJJ_09460 MMJJ_15460(fdhB1)
MAE: Maeo_0577
MTH: MTH_1139
MMG: MTBMA_c15220(fdhB)
MWO: MWSIV6_0698(fdhB1) MWSIV6_1531(fdhB3)
METE: tca_01095
MST: Msp_0639(fdhB)
MRU: mru_0334(fdhB1) mru_2075(fdhB2)
MEB: Abm4_0132(fdhB) Abm4_0854(fdhB2)
MMIL: sm9_1349(flpB) sm9_2182(fdhB)
METH: MBMB1_0103(fdhB)
MFC: BRM9_0167(fdhB)
MFI: DSM1535_1485(fdhB)
MCUB: MCBB_2029(fdhB1) MCBB_2031(fdhB3)
MKA: MK0322
MBAR: MSBR2_2854
MMAC: MSMAC_2581
MHOR: MSHOH_1795
MPY: Mpsy_2943
MHI: Mhar_0324
MBG: BN140_0841(fdhB) BN140_1328(fdhB1) BN140_1330(fdhB2) BN140_2197(fdhB3)
MEMA: MMAB1_1105(fdhB) MMAB1_1690(fdhB) MMAB1_2913(fdhB)
MBN: Mboo_0924
MPD: MCP_1569(fdhB-1) MCP_2406(fdhB-2)
MEZ: Mtc_2124(fdhB)
RCI: RCIX1630(fdhB-1) RCIX2372(fdhB-2) RCIX2376(fdhB-3) RRC252(fdhB-4)
ABI: Aboo_0980
PSYT: DSAG12_02784(fdhB_1) DSAG12_03719(fdhB_2)
 » show all
Reference
  Authors
Lupa B, Hendrickson EL, Leigh JA, Whitman WB
  Title
Formate-dependent H2 production by the mesophilic methanogen Methanococcus maripaludis.
  Journal
Appl Environ Microbiol 74:6584-90 (2008)
DOI:10.1128/AEM.01455-08
Reference
  Authors
Costa KC, Lie TJ, Xia Q, Leigh JA
  Title
VhuD facilitates electron flow from H2 or formate to heterodisulfide reductase in Methanococcus maripaludis.
  Journal
J Bacteriol 195:5160-5 (2013)
DOI:10.1128/JB.00895-13

KEGG   ENZYME: 1.8.98.6
Entry
EC 1.8.98.6                 Enzyme                                 

Name
formate:CoB-CoM heterodisulfide,ferredoxin reductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With other, known, physiological acceptors
Sysname
coenzyme B,coenzyme M,ferredoxin:formate oxidoreductase
Reaction(IUBMB)
2 CO2 + 2 reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + 2 H+ = 2 formate + 2 oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB [RN:R11944]
Reaction(KEGG)
R11944
Substrate
CO2 [CPD:C00011];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
CoB [CPD:C04628];
CoM [CPD:C03576];
H+ [CPD:C00080]
Product
formate [CPD:C00058];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139];
CoM-S-S-CoB [CPD:C04832]
Comment
The enzyme is found in formate-oxidizing CO2-reducing methanogenic archaea such as Methanococcus maripaludis. It consists of a cytoplasmic complex of HdrABC reductase and formate dehydrogenase. Electron pairs donated by formate dehydrogenase are transferred to the HdrA subunit of the reductase, where they are bifurcated, reducing both ferredoxin and CoB-CoM heterodisulfide. cf. EC 1.8.7.3, ferredoxin:CoB-CoM heterodisulfide reductase, EC 1.8.98.4, coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase, EC 1.8.98.5, H2:CoB-CoM heterodisulfide,ferredoxin reductase, and EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase.
History
EC 1.8.98.6 created 2017
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00125  formate dehydrogenase (coenzyme F420) beta subunit
K03388  heterodisulfide reductase subunit A2
K03389  heterodisulfide reductase subunit B2
K03390  heterodisulfide reductase subunit C2
K14127  F420-non-reducing hydrogenase iron-sulfur subunit
K22516  formate dehydrogenase (coenzyme F420) alpha subunit
Genes
VNA: PN96_21155
VEJ: VEJY3_20411
PGB: H744_1c0419
PSH: Psest_3905
PSTU: UIB01_19765
PCH: EY04_14750
PSED: DM292_16890
GNI: GNIT_2862
TIG: THII_2280
THIS: HZT40_21385
TNI: TVNIR_3244(hdrB_[H]) TVNIR_3245(hdlC_[H]) TVNIR_3247(hdrA_[H]) TVNIR_3248(hdlB_[H])
SLIM: SCL_2520
TBN: TBH_C2777
ENM: EBS_2145(hdrB)
CBX: Cenrod_2147(hdrA) Cenrod_2148(mvhD)
SHD: SUTH_02769(hdrB)
TBD: Tbd_1645
SDR: SCD_n01881(hdrB)
CCO: CCC13826_0200(fdhH)
CCOC: CCON33237_0536(fdhH)
CGRA: CGRAC_1361(fdhH)
CPIN: CPIN18020_0262(fdhH)
CGEO: CGEO_1649(fdhH)
CMUC: CMCT_1635(fdhH)
AHS: AHALO_1025(fdhH)
AMAR: AMRN_1963(fdhH)
ACAA: ACAN_2017(fdhH)
SULJ: SJPD1_1032
GSU: GSU0090(hdrA) GSU0091(hdrB) GSU0092(hdrC)
GSK: KN400_0064(hdrG) KN400_0065(hdrA) KN400_0066(hdrB) KN400_0067(hdrC)
GME: Gmet_2083(bamF) Gmet_2084(bamE) Gmet_3424(hdrC) Gmet_3425(hdrB) Gmet_3426(hdrA)
GBM: Gbem_0030(hdrA) Gbem_0031(hdrB) Gbem_0032(hdrC) Gbem_1447(bamE) Gbem_1448(bamF)
GEO: Geob_0149 Geob_0215(bamE-1) Geob_0216(bamF-1) Geob_0231(bamE-2) Geob_0232(bamF-2) Geob_3721(hdrG) Geob_3723(hdrA) Geob_3724(hdrB) Geob_3725(hdrC)
PCA: Pcar_2701
DVU: DVU2402(hdrA) DVU2403(hdrB) DVU2404(hdrC)
DGG: DGI_1048(hdrC) DGI_1049(hdrB) DGI_1050(hdrA) DGI_1051(floxD) DGI_1052(floxC)
DTR: RSDT_0565(hdrC) RSDT_0566(hdrB) RSDT_0567(hdrA)
DPI: BN4_11858(hdrC) BN4_11859(hdrB) BN4_11860(hdrA) BN4_11861(mvhD) BN4_11862
DML: Dmul_02420 Dmul_02770(hdrA1) Dmul_24500(bamE) Dmul_28840(mvhD2) Dmul_28860(hdrA2) Dmul_28870(hdrB) Dmul_28880(hdrC)
DAT: HRM2_06460 HRM2_11710(hdrA1) HRM2_11720(mvhD2) HRM2_11850(hdrA2) HRM2_11860(mvhD3) HRM2_11880(fdhA3) HRM2_14330(hdrA3) HRM2_14340(hdrA3') HRM2_14350(mvhD4) HRM2_14370(fdhA4) HRM2_22740(fdhB6) HRM2_22750(hdrA4) HRM2_22760(hdrD2) HRM2_22770(hdrD2') HRM2_30880(mvhD7)
ADE: Adeh_4164
ATX: GCD22_01577(hdrB1) GCD22_02661(hdrB1) GCD22_03145(hdrB) GCD22_03146(hdlC) GCD22_03148(hdrA) GCD22_03149(hdrB1) GCD22_03192(hdrB1) GCD22_03279(hdrA)
BTS: Btus_2496
EFS: EFS1_1216
ENE: ENT_08450
CSQ: CSCA_0253
DSY: DSY1990
DHD: Dhaf_3153
PTH: PTH_1407(RnfC) PTH_1409(FrhD) PTH_1410(HdrA) PTH_1412(HdrB) PTH_1413(GlpC)
SAY: TPY_3529(hdrA)
SFI: SFUL_466
AFO: Afer_0966
DFO: Dform_00920(hdrA) Dform_00940(mvhD|vhcD) Dform_00941(hdrA) Dform_00942(hdrB) Dform_00943(hdrC)
TRO: trd_0153
ASH: AL1_26630
CTE: CT1245 CT1246(hdrA-2)
CTS: Ctha_0136
AAE: aq_391 aq_395(hdrA) aq_398(hdrC) aq_400(hdrB)
HTH: HTH_1878(hdrB1) HTH_1879(hdrC1) HTH_1881(hdrA) HTH_1882(hdrB2) HTH_1883(hdrC2)
MMP: MMP0138(fdhA) MMP0139(fdhB) MMP0821(vhcD) MMP0825(hdrA) MMP1053(hdrB2) MMP1054(hdrC2) MMP1154(hdrC1) MMP1155(hdrB1) MMP1297(fdhB) MMP1298(fdhA) MMP1696(vhuD) MMP1697(hdrA)
MMAK: MMKA1_01430(fdhA) MMKA1_01440(fdhB) MMKA1_09060(vhcD) MMKA1_09100(hdrA) MMKA1_12180(hdrB) MMKA1_12190(hdrC) MMKA1_13320(hdrC) MMKA1_13330(hdrB) MMKA1_15220(fdhB) MMKA1_15230(fdhA) MMKA1_19300(vhuD) MMKA1_19310(hdrA)
MMAO: MMOS7_01690(fdhA) MMOS7_01700(fdhB) MMOS7_08840(vhcD) MMOS7_08880(hdrA) MMOS7_11480(hdrB) MMOS7_11490(hdrC) MMOS7_12620(hdrC) MMOS7_12630(hdrB) MMOS7_14040(fdhB) MMOS7_14050(fdhA) MMOS7_18110(vhuD) MMOS7_18120(hdrA)
MST: Msp_0314(mvhD1) Msp_0638(mvhD2) Msp_0639(fdhB) Msp_0640(fdhA) Msp_1013(hdrB1) Msp_1014(hdrC1) Msp_1476(hdrA1)
MRU: mru_0117(hdrA) mru_0333(fdhA1) mru_0334(fdhB1) mru_0816(hdrC) mru_0817(hdrB1) mru_1908(mvhD1) mru_2074(fdhA2) mru_2075(fdhB2) mru_2076(mvhD2)
MEB: Abm4_0131(fdhA) Abm4_0132(fdhB) Abm4_0853(mvhD2) Abm4_0854(fdhB2) Abm4_0855(fdhA2) Abm4_1308(hdrB2) Abm4_1309(hdrC2) Abm4_1512(mvhD) Abm4_1691(hdrA2)
MMIL: sm9_1348(flpD) sm9_1349(flpB) sm9_1350(flpA) sm9_1716(hdrB3) sm9_1717(hdrC2) sm9_2013(mvhD) sm9_2182(fdhB) sm9_2183(fdhA) sm9_2251(hdrA2)
METH: MBMB1_0103(fdhB) MBMB1_0104(fdhA) MBMB1_1274(hdrB) MBMB1_1275 MBMB1_1663(mvhD) MBMB1_1958(hdrA)
MFC: BRM9_0167(fdhB) BRM9_0168(fdhA) BRM9_0490(hdrB1) BRM9_0491(hdrC1) BRM9_0915(mvhD) BRM9_2298(hdrA2)
MCUB: MCBB_1489(hdrB3) MCBB_1490(hdrC3) MCBB_1968(mvhD) MCBB_2028(fdhA) MCBB_2029(fdhB1) MCBB_2030(vhcD) MCBB_2031(fdhB3) MCBB_2243(hdrA3)
MKA: MK0249(hdrA_1) MK0265(hdrA_2) MK0268(flpD_1) MK0321 MK0322 MK0572(hdrB) MK0573(hdrC) MK0627(flpD_2)
PYN: PNA2_1925
PYS: Py04_1234
TKO: TK2076
TGA: TGAM_0065(mhy2A) TGAM_0249(fdh1A) TGAM_0631(fdhA)
TSI: TSIB_0067
PPAC: PAP_03230
MAC: MA_2868(hdrA) MA_4236(hdrC) MA_4237(hdrB)
MBU: Mbur_0552(hdrA) Mbur_1516(hdrC) Mbur_1517(hdrB)
MCJ: MCON_2237(fdhA) MCON_3279(hdrA) MCON_3282(hdrC) MCON_3283(hdrB)
MBG: BN140_0752(hdrA1) BN140_0841(fdhB) BN140_0842(fdhA) BN140_1327(fdhA1) BN140_1328(fdhB1) BN140_1329(fdhA2) BN140_1330(fdhB2) BN140_1726(hdrC) BN140_1727(hdrB) BN140_1728(hdrA3) BN140_1729(MvhD) BN140_2197(fdhB3) BN140_2198(fdhA3)
MEMA: MMAB1_0971(hdrA) MMAB1_1105(fdhB) MMAB1_1106(fdhA) MMAB1_1689(fdhA) MMAB1_1690(fdhB) MMAB1_2221(hdrC) MMAB1_2222(hdrB) MMAB1_2223(hdrA) MMAB1_2224(vhcD) MMAB1_2913(fdhB) MMAB1_2914(fdhA)
MPD: MCP_1569(fdhB-1) MCP_1570(fdhA-1) MCP_1576(hdrA-1) MCP_1577(hdrB-1) MCP_1578(hdrC-1) MCP_2406(fdhB-2) MCP_2407(fdhA-2) MCP_2767(mvhD-2) MCP_2768(hdrA-2) MCP_2769(hdrB-3) MCP_2770(hdrC-3)
MEZ: Mtc_2124(fdhB) Mtc_2125(fdhA) Mtc_2472(mvhD-2) Mtc_2473(hdrA-2) Mtc_2474(hdrB-2) Mtc_2475(hdrC-2)
RCI: RCIX1628(fdhA-1) RCIX1630(fdhB-1) RCIX2372(fdhB-2) RCIX2373(fdhA-2) RCIX2376(fdhB-3) RCIX2378(fdhA-3) RCIX594(hdrC-2) RCIX595(hdrB-2) RCIX596(hdrA-2) RCIX597(mvhD-1) RRC251(fdhA-4) RRC252(fdhB-4) RRC256(hdrC-3) RRC257(hdrB-3) RRC258(hdrA-3)
HHB: Hhub_2705(fdhA)
HALH: HTSR_1736(fdhA) HTSR_1740(fdhA2)
HHSR: HSR6_1802(fdoG2) HSR6_1806(fdoG3)
HHI: HAH_5041(fdhA)
NMO: Nmlp_2714(fdhA)
HLA: Hlac_1238
HALQ: Hrr1229_013155(fdhF)
HALU: HUG12_20610(fdhF)
HDF: AArcSl_0465(fdoG) AArcSl_1489(fdoG2) AArcSl_1855(hdrA)
HTU: Htur_0685
HALY: HYG82_00570(fdhF)
TAC: Ta0045
TVO: TVG0003442(TVG0003442)
FAI: FAD_1471
MEAR: Mpt1_c02960(hdrC1) Mpt1_c02970(hdrB1) Mpt1_c08830(hdrB2) Mpt1_c08840(hdrC2) Mpt1_c10570(vhcD) Mpt1_c10580(hdrA)
IHO: Igni_1101
IIS: EYM_07315
SSO: SSO1127(hdrC-1) SSO1129(hdrB-1) SSO1131(hdrA) SSO1134(hdrC-2) SSO1135(hdrB-2)
TPE: Tpen_0190
BARC: AOA65_0030(hdrC_1) AOA65_1112(hdrA_1) AOA65_1400(hdrC_2) AOA65_1401(hdrB_2) AOA65_1402(hdrA_3) AOA65_1715(mvhD_1) AOA65_1718(mvhD_2) AOA65_1719(hdlA_2) AOA65_1887(hdrB_3) AOA65_1888(hdrC_3) AOA65_1889(vhcD) AOA65_1993(hdrB_4) AOA65_1994(hdrC_4) AOA65_1995(hdrA_4)
BARB: AOA66_0155(hdrA_1) AOA66_1507(hdrB_1) AOA66_1508(hdrC_1) AOA66_1509(vhcD) AOA66_1510(hdrA_2) AOA66_1511(mvhD) AOA66_1512(hdlA_2) AOA66_1513(hdrA_3) AOA66_1526(hdrA_4) AOA66_1731(hdrB_2) AOA66_1732(hdrC_2)
PSYT: DSAG12_01135(mvhD_1) DSAG12_01136(hdrA_1) DSAG12_01137(hdrB_1) DSAG12_01138(hdrC_1) DSAG12_01145(hdrC_2) DSAG12_01146(hdrB_2) DSAG12_01147(hdrA_2) DSAG12_01148(mvhD_2) DSAG12_01161(hdrB_3) DSAG12_01162(hdrC_3) DSAG12_02253(hdrA_3) DSAG12_02784(fdhB_1) DSAG12_02804(mvhD_4) DSAG12_02805(hdrA_4) DSAG12_02806(hdrC_4) DSAG12_02807(hdrB_4) DSAG12_03218(hdrC_5) DSAG12_03220(hdrA_5) DSAG12_03223(hdrB_5) DSAG12_03719(fdhB_2) DSAG12_03720(vhcD) DSAG12_03721(hdrA_6) DSAG12_03722(mvhD_5) DSAG12_03723(hdlA_4) DSAG12_03724(hdrA_7) DSAG12_03725(hdrB_6) DSAG12_03726(hdrC_6) DSAG12_03952(hdrB_7) DSAG12_03953(hdrC_7)
 » show all
Reference
1  [PMID:20534465]
  Authors
Costa KC, Wong PM, Wang T, Lie TJ, Dodsworth JA, Swanson I, Burn JA, Hackett M, Leigh JA
  Title
Protein complexing in a methanogen suggests electron bifurcation and electron delivery from formate to heterodisulfide reductase.
  Journal
Proc Natl Acad Sci U S A 107:11050-5 (2010)
DOI:10.1073/pnas.1003653107
Reference
2  [PMID:24039260]
  Authors
Costa KC, Lie TJ, Xia Q, Leigh JA
  Title
VhuD facilitates electron flow from H2 or formate to heterodisulfide reductase in Methanococcus maripaludis.
  Journal
J Bacteriol 195:5160-5 (2013)
DOI:10.1128/JB.00895-13
Other DBs
ExplorEnz - The Enzyme Database: 1.8.98.6
IUBMB Enzyme Nomenclature: 1.8.98.6
ExPASy - ENZYME nomenclature database: 1.8.98.6
BRENDA, the Enzyme Database: 1.8.98.6

KEGG   REACTION: R11944
Entry
R11944                      Reaction                               

Name
coenzyme B,coenzyme M,ferredoxin:formate oxidoreductase
Definition
Coenzyme B + Coenzyme M + 2 Reduced ferredoxin + 2 CO2 + 2 H+ <=> Coenzyme M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide + 2 Oxidized ferredoxin + 2 Formate
Equation
C04628 + C03576 + 2 C00138 + 2 C00011 + 2 C00080 <=> C04832 + 2 C00139 + 2 C00058
Reaction class
RC00011  C03576_C04832  C04628_C04832
Enzyme
Pathway
rn00680  Methane metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
M00357  Methanogenesis, acetate => methane
M00563  Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00567  Methanogenesis, CO2 => methane
Orthology
K00125  formate dehydrogenase (coenzyme F420) beta subunit [EC:1.17.98.3 1.8.98.6]
K03388  heterodisulfide reductase subunit A2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]
K03389  heterodisulfide reductase subunit B2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]
K03390  heterodisulfide reductase subunit C2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]
K14127  F420-non-reducing hydrogenase iron-sulfur subunit [EC:1.12.99.- 1.8.98.5 1.8.98.6]
K22516  formate dehydrogenase (coenzyme F420) alpha subunit [EC:1.17.98.3 1.8.98.6]

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