KEGG ORTHOLOGY: K03479

ORTHOLOGY: K03479

Entry

K03479 KO

Name

SIAT7A, ST6GalNAc I

Definition

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7A) [EC:2.4.99.3]

Pathway

ko00512

Mucin type O-glycan biosynthesis

ko01100

Metabolic pathways

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00512 Mucin type O-glycan biosynthesis
    K03479  SIAT7A, ST6GalNAc I; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7A)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K03479  SIAT7A, ST6GalNAc I; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7A)
Enzymes [BR:ko01000]
2. Transferases
  2.4  Glycosyltransferases
   2.4.99  Transferring other glycosyl groups
    2.4.99.3  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
     K03479  SIAT7A, ST6GalNAc I; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7A)
Glycosyltransferases [BR:ko01003]
Terminal extension
  Sialyltransferase
   K03479  SIAT7A, ST6GalNAc I; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7A)

Other DBs

RN:	R05911 R05914

GO:

0001665

CAZy:

GT29

Genes

HSA:	55808(ST6GALNAC1)

PTR:	449516(ST6GALNAC1)

PPS:	100990954(ST6GALNAC1)

GGO:	101131564(ST6GALNAC1)

PON:	100437242(ST6GALNAC1)

NLE:	100582568(ST6GALNAC1)

MCC:	707339(ST6GALNAC1)

MCF:	102131184(ST6GALNAC1)

CSAB:

103242998(ST6GALNAC1)

RRO:	104681265(ST6GALNAC1)

RBB:	108537385(ST6GALNAC1)

CJC:	100394846(ST6GALNAC1)

SBQ:	101052905(ST6GALNAC1)

MMU:	20445(St6galnac1)

MCAL:

110287813 110306209(St6galnac1)

MPAH:

110331893 110332478

RNO:	287920(St6galnac1)

MUN:	110566009(St6galnac1)

CGE:	100763224 113836687

NGI:	103732779(St6galnac1)

HGL:	101716443(St6galnac1)

CCAN:

109685592(St6galnac1)

OCU:	100357022(ST6GALNAC1)

TUP:	102502337(ST6GALNAC1)

CFA:	100049002(ST6GALNAC1)

VVP:	112920614(ST6GALNAC1)

AML:	100483351(ST6GALNAC1)

UMR:	103665769(ST6GALNAC1)

UAH:	113244589(ST6GALNAC1)

ORO:	101373308(ST6GALNAC1)

ELK:

111160465

FCA:	101085418(ST6GALNAC1)

PTG:	102954578(ST6GALNAC1)

PPAD:

109276888(ST6GALNAC1)

AJU:	106987766(ST6GALNAC1)

BTA:	618655(ST6GALNAC1)

BOM:	102285967(ST6GALNAC1)

BIU:	109573345(ST6GALNAC1)

BBUB:

102415715(ST6GALNAC1)

CHX:	102184000(ST6GALNAC1)

OAS:	101116588(ST6GALNAC1)

SSC:	100622490(ST6GALNAC1)

CFR:	102521946(ST6GALNAC1)

CDK:	105092179(ST6GALNAC1)

BACU:

103012251(ST6GALNAC1)

LVE:	103071465(ST6GALNAC1)

OOR:	101286810(ST6GALNAC1)

DLE:	111182936(ST6GALNAC1)

ECB:	100058687(ST6GALNAC1)

EPZ:	103565524(ST6GALNAC1)

EAI:	106830340(ST6GALNAC1)

MYB:	102256773(ST6GALNAC1)

MYD:	102763652(ST6GALNAC1)

MNA:	107536587(ST6GALNAC1)

HAI:	109383649(ST6GALNAC1)

DRO:	112298677(ST6GALNAC1)

PALE:

102898342(ST6GALNAC1)

RAY:	107510029(ST6GALNAC1)

MJV:	108398661(ST6GALNAC1)

LAV:	100667338(ST6GALNAC1)

TMU:

101348933

SHR:	100913684(ST6GALNAC1)

OAA:	100076453(ST6GALNAC1)

GGA:	396168(ST6GALNAC1)

MGP:	100549131(ST6GALNAC1)

CJO:	107322110(ST6GALNAC1)

NMEL:

110407369(ST6GALNAC1)

APLA:

101797291(ST6GALNAC1)

ACYG:

106034632(ST6GALNAC1)

TGU:	100227473(ST6GALNAC1)

LSR:	110479610(ST6GALNAC1)

SCAN:

103820005(ST6GALNAC1)

GFR:	102044354(ST6GALNAC1)

FAB:	101816531(ST6GALNAC1)

PHI:	102104528(ST6GALNAC1)

PMAJ:

107212525(ST6GALNAC1)

CCAE:

111937266(ST6GALNAC1)

CCW:	104694336(ST6GALNAC1)

ETL:	114058601(ST6GALNAC1)

FPG:	101917973(ST6GALNAC1)

FCH:	102046634(ST6GALNAC1)

CLV:	102096307(ST6GALNAC1)

EGZ:	104125375(ST6GALNAC1)

NNI:	104022870(ST6GALNAC1)

ACUN:

113486705(ST6GALNAC1)

PADL:

103921018(ST6GALNAC1)

AAM:	106485391(ST6GALNAC1)

ASN:	102380149(ST6GALNAC1)

AMJ:	102567931(ST6GALNAC1)

CMY:	102934815(ST6GALNAC1)

CPIC:

101952335(ST6GALNAC1)

ACS:	100552576(st6galnac1)

PVT:	110085897(ST6GALNAC1)

PBI:	103049161(ST6GALNAC1)

PMUR:

107300765(ST6GALNAC1)

TSR:

106546339

PMUA:

114590659(ST6GALNAC1)

GJA:	107118138(ST6GALNAC1)

XLA:	108701136 108702827

XTR:	101733431(st6galnac1)

NPR:	108786396(ST6GALNAC1)

DRE:	564336(st6galnac1.1) 799868(st6galnac1.2)

SRX:	107721981 107721986 107734167 107734198

SANH:

107660869 107660870 107692092 107692094

SGH:	107577723 107584072 107584073

CCAR:

109100113 109110781

IPU:

108273438

PHYP:

113527221(st6galnac1)

AMEX:

103028114 111196612

EEE:	113572794 113582980

LCO:	104937002 104937003

NCC:

104956443

MZE:	101474318 101474872 101475163 101481664 112430022

ONL:	100691443 100691711 100691981 100692518 100698116 100708495 100708765 100709034 106097985 109203140 112847711

OLA:

101164026

XMA:	102225407 102225672 102230432

XCO:	114151667 114152135 114152366

PRET:

103481510 103481511 103481513

CVG:	107088933 107089181 107089188

NFU:	107387721 107387723 107387725

KMR:	108246104 108246110 108249294

ALIM:

106516657 106516659 106516660

AOCE:

111583259

CSEM:

103381823(st6galnac2)

POV:

109643035

LCF:

108876231

SDU:	111219599(st6galnac1)

SLAL:

111673497(st6galnac1)

HCQ:	109516217 109516279

BPEC:

110165448 110166304

MALB:

109953680

SASA:

106570212 106589847

OTW:	112229175 112229683

SALP:

ELS:

SFM:

PKI:

BFO:	118406423 118407349 118410756 118411095 118414746 118424170 118430484 118431407

SPU:	105437315 115929913 581003

APLC:

110973336 110973337 110973339 110973340 110973577 110973580 110982145 110983162

SKO:	102803687 102808553

» show all

Reference

PMID:10788794

Authors

Kurosawa N, Takashima S, Kono M, Ikehara Y, Inoue M, Tachida Y, Narimatsu H, Tsuji S

Title

Molecular cloning and genomic analysis of mouse GalNAc alpha2, 6-sialyltransferase (ST6GalNAc I).

Journal

J Biochem 127:845-54 (2000)
DOI:10.1093/oxfordjournals.jbchem.a022678

Sequence

[mmu:20445]

All links

Ontology (5)   
   KEGG BRITE (3)   
   GO (1)   
   CAZY (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Gene (338)   
   KEGG GENES (207)   
   KEGG MGENES (73)   
   RefGene (55)   
   OC (3)   
Literature (1)   
   PubMed (1)   
All databases (351)   

Download RDF

ENZYME: 2.4.99.3

Entry

EC 2.4.99.3 Enzyme

Name

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase

Class

Transferases;
Glycosyltransferases;
Transferring other glycosyl groups

Sysname

CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase

Reaction(IUBMB)

CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein [RN:R05911]

Reaction(KEGG)

R05911(G) > R05914(G) R06273(G)

Substrate

CMP-N-acetylneuraminate [CPD:C00128];
glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein

Product

CMP [CPD:C00055];
glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein

Comment

alpha-N-Acetylgalactosamine linked to threonine or serine is also an acceptor, when substituted at the 3-position.

History

EC 2.4.99.3 created 1984, modified 1986

Pathway

ec00512

Mucin type O-glycan biosynthesis

ec01100

Metabolic pathways

Orthology

K03479

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7A)

Genes

HSA:	55808(ST6GALNAC1)

PTR:	449516(ST6GALNAC1)

PPS:	100990954(ST6GALNAC1)

GGO:	101131564(ST6GALNAC1)

PON:	100437242(ST6GALNAC1)

NLE:	100582568(ST6GALNAC1)

MCC:	707339(ST6GALNAC1)

MCF:	102131184(ST6GALNAC1)

CSAB:

103242998(ST6GALNAC1)

RRO:	104681265(ST6GALNAC1)

RBB:	108537385(ST6GALNAC1)

CJC:	100394846(ST6GALNAC1)

SBQ:	101052905(ST6GALNAC1)

MMU:	20445(St6galnac1)

MCAL:

110287813 110306209(St6galnac1)

MPAH:

110331893 110332478

RNO:	287920(St6galnac1)

MUN:	110566009(St6galnac1)

CGE:	100763224 113836687

NGI:	103732779(St6galnac1)

HGL:	101716443(St6galnac1)

CCAN:

109685592(St6galnac1)

OCU:	100357022(ST6GALNAC1)

TUP:	102502337(ST6GALNAC1)

CFA:	100049002(ST6GALNAC1)

VVP:	112920614(ST6GALNAC1)

AML:	100483351(ST6GALNAC1)

UMR:	103665769(ST6GALNAC1)

UAH:	113244589(ST6GALNAC1)

ORO:	101373308(ST6GALNAC1)

ELK:

111160465

FCA:	101085418(ST6GALNAC1)

PTG:	102954578(ST6GALNAC1)

PPAD:

109276888(ST6GALNAC1)

AJU:	106987766(ST6GALNAC1)

BTA:	618655(ST6GALNAC1)

BOM:	102285967(ST6GALNAC1)

BIU:	109573345(ST6GALNAC1)

BBUB:

102415715(ST6GALNAC1)

CHX:	102184000(ST6GALNAC1)

OAS:	101116588(ST6GALNAC1)

SSC:	100622490(ST6GALNAC1)

CFR:	102521946(ST6GALNAC1)

CDK:	105092179(ST6GALNAC1)

BACU:

103012251(ST6GALNAC1)

LVE:	103071465(ST6GALNAC1)

OOR:	101286810(ST6GALNAC1)

DLE:	111182936(ST6GALNAC1)

ECB:	100058687(ST6GALNAC1)

EPZ:	103565524(ST6GALNAC1)

EAI:	106830340(ST6GALNAC1)

MYB:	102256773(ST6GALNAC1)

MYD:	102763652(ST6GALNAC1)

MNA:	107536587(ST6GALNAC1)

HAI:	109383649(ST6GALNAC1)

DRO:	112298677(ST6GALNAC1)

PALE:

102898342(ST6GALNAC1)

RAY:	107510029(ST6GALNAC1)

MJV:	108398661(ST6GALNAC1)

LAV:	100667338(ST6GALNAC1)

TMU:

101348933

SHR:	100913684(ST6GALNAC1)

OAA:	100076453(ST6GALNAC1)

GGA:	396168(ST6GALNAC1)

MGP:	100549131(ST6GALNAC1)

CJO:	107322110(ST6GALNAC1)

NMEL:

110407369(ST6GALNAC1)

APLA:

101797291(ST6GALNAC1)

ACYG:

106034632(ST6GALNAC1)

TGU:	100227473(ST6GALNAC1)

LSR:	110479610(ST6GALNAC1)

SCAN:

103820005(ST6GALNAC1)

GFR:	102044354(ST6GALNAC1)

FAB:	101816531(ST6GALNAC1)

PHI:	102104528(ST6GALNAC1)

PMAJ:

107212525(ST6GALNAC1)

CCAE:

111937266(ST6GALNAC1)

CCW:	104694336(ST6GALNAC1)

ETL:	114058601(ST6GALNAC1)

FPG:	101917973(ST6GALNAC1)

FCH:	102046634(ST6GALNAC1)

CLV:	102096307(ST6GALNAC1)

EGZ:	104125375(ST6GALNAC1)

NNI:	104022870(ST6GALNAC1)

ACUN:

113486705(ST6GALNAC1)

PADL:

103921018(ST6GALNAC1)

AAM:	106485391(ST6GALNAC1)

ASN:	102380149(ST6GALNAC1)

AMJ:	102567931(ST6GALNAC1)

CMY:	102934815(ST6GALNAC1)

CPIC:

101952335(ST6GALNAC1)

ACS:	100552576(st6galnac1)

PVT:	110085897(ST6GALNAC1)

PBI:	103049161(ST6GALNAC1)

PMUR:

107300765(ST6GALNAC1)

TSR:

106546339

PMUA:

114590659(ST6GALNAC1)

GJA:	107118138(ST6GALNAC1)

XLA:	108701136 108702827

XTR:	101733431(st6galnac1)

NPR:	108786396(ST6GALNAC1)

DRE:	564336(st6galnac1.1) 799868(st6galnac1.2)

SRX:	107721981 107721986 107734167 107734198

SANH:

107660869 107660870 107692092 107692094

SGH:	107577723 107584072 107584073

CCAR:

109100113 109110781

IPU:

108273438

PHYP:

113527221(st6galnac1)

AMEX:

103028114 111196612

EEE:	113572794 113582980

LCO:	104937002 104937003

NCC:

104956443

MZE:	101474318 101474872 101475163 101481664 112430022

ONL:	100691443 100691711 100691981 100692518 100698116 100708495 100708765 100709034 106097985 109203140 112847711

OLA:

101164026

XMA:	102225407 102225672 102230432

XCO:	114151667 114152135 114152366

PRET:

103481510 103481511 103481513

CVG:	107088933 107089181 107089188

NFU:	107387721 107387723 107387725

KMR:	108246104 108246110 108249294

ALIM:

106516657 106516659 106516660

AOCE:

111583259

CSEM:

103381823(st6galnac2)

POV:

109643035

LCF:

108876231

SDU:	111219599(st6galnac1)

SLAL:

111673497(st6galnac1)

HCQ:	109516217 109516279

BPEC:

110165448 110166304

MALB:

109953680

SASA:

106570212 106589847

OTW:	112229175 112229683

SALP:

ELS:

SFM:

PKI:

BFO:	118406423 118407349 118410756 118411095 118414746 118424170 118430484 118431407

SPU:	105437315 115929913 581003

APLC:

110973336 110973337 110973339 110973340 110973577 110973580 110982145 110983162

SKO:	102803687 102808553

» show all

Reference

1 [PMID:447688]

Authors

Sadler JE, Rearick JI, Hill RL.

Title

Purification to homogeneity and enzymatic characterization of an alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase from porcine submaxillary glands.

Journal

J Biol Chem 254:5934-41 (1979)

Other DBs

ExplorEnz - The Enzyme Database:

2.4.99.3

IUBMB Enzyme Nomenclature:

2.4.99.3

ExPASy - ENZYME nomenclature database:

2.4.99.3

BRENDA, the Enzyme Database:

2.4.99.3

CAS:	71124-50-0

REACTION: R05911

Entry

R05911 Reaction

Definition

CMP-N-acetylneuraminate + Tn antigen <=> CMP + Sialyl-Tn antigen

Equation

G10616 + G00023 <=> G10621 + G00035

Enzyme

2.4.99.3

Pathway

rn00512

Mucin type O-glycan biosynthesis

rn01100

Metabolic pathways

Orthology

K03479

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7A) [EC:2.4.99.3]

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG GLYCAN (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (208)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (207)   
All databases (220)   

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