KEGG   ORTHOLOGY: K03823
Entry
K03823                      KO                                     

Name
pat, bar
Definition
phosphinothricin acetyltransferase [EC:2.3.1.183]
Pathway
ko00440  Phosphonate and phosphinate metabolism
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00440 Phosphonate and phosphinate metabolism
    K03823  pat, bar; phosphinothricin acetyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.183  phosphinothricin acetyltransferase
     K03823  pat, bar; phosphinothricin acetyltransferase
Other DBs
RN: R08871 R08938
COG: COG1247
GO: 0102971
Genes
VCH: VCA0387
VCF: IR04_01735
VCE: Vch1786_II0131
VCQ: EN18_00605
VCJ: VCD_000902
VCI: O3Y_15323
VCO: VC0395_0935
VCR: VC395_A0337
VPH: VPUCM_1431
VEX: VEA_003223
VSP: VS_1280
LSS: NCTC12082_01565(yncA)
RBS: RHODOSMS8_00830(bar)
SCO: SCO3203(bar)
SALB: XNR_2143
SMA: SAVERM_3695(bar)
SCT: SCAT_p1305(bar)
SFA: Sfla_3685
SHY: SHJG_4675
SALS: SLNWT_4368
SFI: SFUL_4404
SALU: DC74_3670
SALL: SAZ_19480
SLV: SLIV_21675(bar)
STRE: GZL_05219
SLD: T261_4846
SPRI: SPRI_4346
SRW: TUE45_04449(pat_2)
STRD: NI25_22705
SALJ: SMD11_5982(pat)
SFK: KY5_3412
SGE: DWG14_04848(bar)
AG: CAA35093(bar)
 » show all
Reference
PMID:1916276
  Authors
Bedford DJ, Lewis CG, Buttner MJ
  Title
Characterization of a gene conferring bialaphos resistance in Streptomyces coelicolor A3(2).
  Journal
Gene 104:39-45 (1991)
DOI:10.1016/0378-1119(91)90462-k
  Sequence
[sco:SCO3203]
Reference
PMID:2315036
  Authors
White J, Chang SY, Bibb MJ, Bibb MJ
  Title
A cassette containing the bar gene of Streptomyces hygroscopicus: a selectable marker for plant transformation.
  Journal
Nucleic Acids Res 18:1062 (1990)
DOI:10.1093/nar/18.4.1062
  Sequence

KEGG   ENZYME: 2.3.1.183
Entry
EC 2.3.1.183                Enzyme                                 

Name
phosphinothricin acetyltransferase;
PAT (ambiguous);
PPT acetyltransferase;
Pt-N-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:phosphinothricin N-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + phosphinothricin = CoA + N-acetylphosphinothricin [RN:R08938]
Reaction(KEGG)
R08938;
(other) R08871
Substrate
acetyl-CoA [CPD:C00024];
phosphinothricin [CPD:C04650]
Product
CoA [CPD:C00010];
N-acetylphosphinothricin [CPD:C17952]
Comment
The substrate phosphinothricin is used as a nonselective herbicide and is a potent inhibitor of EC 6.3.1.2, glutamine synthetase, a key enzyme of nitrogen metabolism in plants [2].
History
EC 2.3.1.183 created 2007
Pathway
ec00440  Phosphonate and phosphinate metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K03823  phosphinothricin acetyltransferase
Genes
VCH: VCA0387
VCF: IR04_01735
VCE: Vch1786_II0131
VCQ: EN18_00605
VCJ: VCD_000902
VCI: O3Y_15323
VCO: VC0395_0935
VCR: VC395_A0337
VPH: VPUCM_1431
VEX: VEA_003223
VSP: VS_1280
LSS: NCTC12082_01565(yncA)
RBS: RHODOSMS8_00830(bar)
SCO: SCO3203(bar)
SALB: XNR_2143
SMA: SAVERM_3695(bar)
SCT: SCAT_p1305(bar)
SFA: Sfla_3685
SHY: SHJG_4675
SALS: SLNWT_4368
SFI: SFUL_4404
SALU: DC74_3670
SALL: SAZ_19480
SLV: SLIV_21675(bar)
STRE: GZL_05219
SLD: T261_4846
SPRI: SPRI_4346
SRW: TUE45_04449(pat_2)
STRD: NI25_22705
SALJ: SMD11_5982(pat)
SFK: KY5_3412
SGE: DWG14_04848(bar)
 » show all
Reference
1  [PMID:1864506]
  Authors
Botterman J, Gossele V, Thoen C, Lauwereys M.
  Title
Characterization of phosphinothricin acetyltransferase and C-terminal enzymatically active fusion proteins.
  Journal
Gene 102:33-7 (1991)
DOI:10.1016/0378-1119(91)90534-I
Reference
2  [PMID:12232195]
  Authors
Droge-Laser W, Siemeling U, Puhler A, Broer I.
  Title
The Metabolites of the Herbicide L-Phosphinothricin (Glufosinate) (Identification, Stability, and Mobility in Transgenic, Herbicide-Resistant, and Untransformed Plants).
  Journal
Plant Physiol 105:159-166 (1994)
DOI:10.1104/pp.105.1.159
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.183
IUBMB Enzyme Nomenclature: 2.3.1.183
ExPASy - ENZYME nomenclature database: 2.3.1.183
BRENDA, the Enzyme Database: 2.3.1.183

KEGG   REACTION: R08871
Entry
R08871                      Reaction                               

Name
acetyl-CoA:demethylphosphinothricin N-acetyltransferase
Definition
Demethylphosphinothricin + Acetyl-CoA <=> N-Acetyldemethylphosphinothricin + CoA
Equation
Comment
phosphinothricin acetyltransferase
Reaction class
RC00004  C00010_C00024
RC00064  C17949_C17962
Enzyme
Pathway
rn00440  Phosphonate and phosphinate metabolism
rn01110  Biosynthesis of secondary metabolites
Orthology
K03823  phosphinothricin acetyltransferase [EC:2.3.1.183]

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