KEGG   ORTHOLOGY: K03843
Entry
K03843                      KO                                     

Name
ALG2
Definition
alpha-1,3/alpha-1,6-mannosyltransferase [EC:2.4.1.132 2.4.1.257]
Pathway
ko00510  N-Glycan biosynthesis
ko00513  Various types of N-glycan biosynthesis
ko01100  Metabolic pathways
Module
M00055  N-glycan precursor biosynthesis
Disease
H00118  Congenital disorders of glycosylation type I
H00770  Congenital myasthenic syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00510 N-Glycan biosynthesis
    K03843  ALG2; alpha-1,3/alpha-1,6-mannosyltransferase
   00513 Various types of N-glycan biosynthesis
    K03843  ALG2; alpha-1,3/alpha-1,6-mannosyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K03843  ALG2; alpha-1,3/alpha-1,6-mannosyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.132  GDP-Man:Man1GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase
     K03843  ALG2; alpha-1,3/alpha-1,6-mannosyltransferase
    2.4.1.257  GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase
     K03843  ALG2; alpha-1,3/alpha-1,6-mannosyltransferase
Glycosyltransferases [BR:ko01003]
 N-Glycan biosynthesis
  Dol-linked oligosaccharide
   K03843  ALG2; alpha-1,3/alpha-1,6-mannosyltransferase
Other DBs
RN: R05973 R06238
CAZy: GT4
Genes
HSA: 85365(ALG2)
PTR: 472993(ALG2)
PPS: 100984805(ALG2)
GGO: 101128869(ALG2)
PON: 100451740(ALG2)
NLE: 100593183(ALG2)
MCC: 714850(ALG2)
MCF: 102146841(ALG2)
CSAB: 103219138(ALG2)
RRO: 104657764(ALG2)
RBB: 108512462(ALG2)
CJC: 100388149(ALG2)
SBQ: 101030903(ALG2)
MMU: 56737(Alg2)
MCAL: 110292619(Alg2)
MPAH: 110323013(Alg2)
RNO: 313231(Alg2)
MUN: 110556433 110556434
CGE: 100768412(Alg2)
NGI: 103749080(Alg2)
HGL: 101717738(Alg2)
CCAN: 109691420(Alg2)
OCU: 100353637(ALG2)
TUP: 102477233(ALG2)
CFA: 474780(ALG2)
VVP: 112930771(ALG2)
AML: 100471257(ALG2)
UMR: 103678628(ALG2)
UAH: 113260403(ALG2)
ORO: 101379758(ALG2)
ELK: 111145785
FCA: 101084066(ALG2)
PTG: 102963679(ALG2)
PPAD: 109270077(ALG2)
AJU: 106972044(ALG2)
BTA: 538899(ALG2)
BOM: 102282554(ALG2)
BIU: 109563080(ALG2)
BBUB: 102397326(ALG2)
CHX: 102172999(ALG2)
OAS: 101101953(ALG2)
SSC: 100113423(ALG2)
CFR: 102523932(ALG2)
CDK: 105086888(ALG2)
BACU: 102999901(ALG2)
LVE: 103071670(ALG2)
OOR: 101287811(ALG2)
DLE: 111188084(ALG2)
PCAD: 102982177(ALG2)
ECB: 100054840(ALG2)
EPZ: 103555265(ALG2)
EAI: 106842922(ALG2)
MYB: 102241662(ALG2)
MYD: 102764897(ALG2)
MNA: 107544878(ALG2)
HAI: 109386428(ALG2)
DRO: 112304450(ALG2)
PALE: 102880508(ALG2)
RAY: 107500590(ALG2)
MJV: 108394149(ALG2)
LAV: 100655996(ALG2)
TMU: 101352514
MDO: 100011371(ALG2)
SHR: 100913580(ALG2)
PCW: 110214538(ALG2)
OAA: 100092424(ALG2)
GGA: 420998(ALG2)
MGP: 100538726(ALG2)
CJO: 107309970(ALG2)
NMEL: 110393668(ALG2)
APLA: 101795871(ALG2)
ACYG: 106035960(ALG2)
TGU: 100190655(ALG2)
LSR: 110469741(ALG2)
SCAN: 103826142(ALG2)
GFR: 102032538(ALG2)
FAB: 101820728(ALG2)
PHI: 102103653(ALG2)
PMAJ: 107200761(ALG2)
CCAE: 111925280(ALG2)
CCW: 104685901(ALG2)
ETL: 114058961(ALG2)
FPG: 101912340(ALG2)
FCH: 102058016(ALG2)
CLV: 102093093(ALG2)
EGZ: 104130440(ALG2)
NNI: 104018204(ALG2)
ACUN: 113477198(ALG2)
PADL: 103917756(ALG2)
AAM: 106496984(ALG2)
ASN: 102370298(ALG2)
AMJ: 102564853(ALG2)
PSS: 102460786(ALG2)
CMY: 102940919
CPIC: 101942628(ALG2)
ACS: 103279177(alg2)
PVT: 110086078(ALG2)
PBI: 103051382(ALG2)
PMUR: 107291673(ALG2)
TSR: 106538359(ALG2)
PMUA: 114582036(ALG2)
GJA: 107110593(ALG2)
XLA: 446622(alg2.L)
XTR: 595052(alg2)
NPR: 108797276(ALG2)
DRE: 403068(alg2)
SRX: 107706186 107706481 107723517
SANH: 107657723 107687815
SGH: 107593685 107595974
IPU: 108256665(alg2)
PHYP: 113532962(alg2)
AMEX: 103028771(alg2)
EEE: 113590840(alg2)
TRU: 101076494(alg2)
TNG: GSTEN00034041G001
LCO: 104923022(alg2)
NCC: 104966077(alg2)
MZE: 101484363(alg2)
ONL: 100701749(alg2)
OLA: 101167069(alg2)
XMA: 102222028(alg2)
XCO: 114141939(alg2)
PRET: 103478647(alg2)
CVG: 107102914(alg2)
NFU: 107379741(alg2)
KMR: 108241118(alg2)
ALIM: 106527090(alg2)
AOCE: 111577777(alg2)
CSEM: 103388137(alg2)
POV: 109633440(alg2)
LCF: 108889631(alg2)
SDU: 111236927(alg2)
SLAL: 111650852(alg2)
HCQ: 109515460(alg2)
BPEC: 110171549(alg2)
MALB: 109964158(alg2)
SASA: 106574526 106606060
OTW: 112240345(alg2)
SALP: 112076465(alg2)
ELS: 105018904(alg2)
SFM: 108940512(alg2)
PKI: 111845856(alg2)
LCM: 102353262(ALG2)
CMK: 103181173(alg2)
BFO: BRAFLDRAFT_70178
CIN: 100180226
SPU: 115928701 589943
APLC: 110977698
SKO: 100371989
DME: Dmel_CG1291(Alg2)
DER: 6543647
DSE: 6610565
DSI: Dsimw501_GD13727(Dsim_GD13727)
DYA: Dyak_GE20359
DAN: 6506901
DSR: 110182775
DPO: Dpse_GA11900
DPE: 113566407
DMN: 108151759
DWI: 6646055
DGR: Dgri_GH15819
DMO: Dmoj_GI12600
DAZ: 108613374
DNV: 108651329
DHE: 111591933
DVI: 6623162
MDE: 101891935
LCQ: 111680696
AGA: AgaP_AGAP001232
AAG: 5575716
AALB: 109431792
AME: 551972
BIM: 100740485
BTER: 100647541
CCAL: 108626003
OBB: 114878353
SOC: 105207380
MPHA: 105838058
AEC: 105149006
ACEP: 105622020
PBAR: 105433355
VEM: 105565242
HST: 105192054
DQU: 106751846
CFO: 105249015
LHU: 105679897
PGC: 109862973
OBO: 105288046
PCF: 106784395
NVI: 100122589
CSOL: 105367225
MDL: 103576080
TCA: 657332
DPA: 109544912 109546697
ATD: 109601758 109607356
NVL: 108560004 108560581
BMOR: 101737122
BMAN: 114250453
DPL: KGM_212052
PMAC: 106707690
PRAP: 110992446
HAW: 110376252
TNL: 113499527
PXY: 105390412
API: 100164916
DNX: 107167633
AGS: 114128688
RMD: 113547805
BTAB: 109044497
CLEC: 106662501
PHU: Phum_PHUM599360
ZNE: 110826715
FCD: 110848787
DPX: DAPPUDRAFT_192054
PVM: 113807059
ISC: IscW_ISCW008177
TUT: 107361675
DPTE: 113792811
CSCU: 111618264 111618267
PTEP: 107448020
CEL: CELE_F09E5.2(algn-2)
CBR: CBG02380
BMY: Bm1_01370
LOA: LOAG_01337 LOAG_02361
NAI: NECAME_06664
TSP: Tsp_11159 Tsp_11653
HRO: HELRODRAFT_110729
LGI: LOTGIDRAFT_224255
PCAN: 112574345
CRG: 105336633
MYI: 110458513
OBI: 106873336
LAK: 106155289 106164980
SMM: Smp_177080
SHX: MS3_01525
OVI: T265_04788
EGL: EGR_09601
NVE: 5517178
EPA: 110235219
ADF: 107335169
AMIL: 114952865
SPIS: 111340459
DGT: 114533068 114534204
HMG: 101238397
AQU: 100632336
ATH: AT1G78800
ALY: 9325273
CRB: 17894620
CSAT: 104703214 104752305
EUS: EUTSA_v10007837mg EUTSA_v10019736mg
BRP: 103832355
BNA: 106354674
BOE: 106298287
THJ: 104812317
CPAP: 110812537
CIT: 102626306
CIC: CICLE_v10020399mg
TCC: 18594241
GRA: 105777281
GHI: 107917782 107944455
GAB: 108480381
DZI: 111275922 111275924
EGR: 104448547
GMX: 100800839 100809168
GSJ: 114373873 114379181
PVU: PHAVU_005G081600g
VRA: 106778117
VAR: 108321952
VUN: 114183384
CCAJ: 109811934
MTR: MTR_1g104880
CAM: 101501052
ADU: 107458069 107459779
AIP: 107609313 107613290
LANG: 109348100 109357267
FVE: 101292974
RCN: 112165984
PPER: 18778069 18779540
PMUM: 103328865 103342728
PAVI: 110754544 110771820
MDM: 103448776
PXB: 103934886
ZJU: 107403902 107432555
CSV: 101211733 101222455
CMO: 103492951
MCHA: 111012924
CMAX: 111480394
CMOS: 111447959
CPEP: 111781399
RCU: 8276386
JCU: 105637031
HBR: 110670322 110670335 110671298
MESC: 110612091
POP: 7472343
PEU: 105139363
JRE: 109012141
QSU: 111995463 112000262 112040101
VVI: 100248737
SLY: 101245960
SPEN: 107021358
SOT: 102603181
CANN: 107875413
NTA: 107792493 107828501
NSY: 104220522
NTO: 104117000
NAU: 109211705 109228734
INI: 109163384 109175932
SIND: 105176930
OEU: 111370834 111395563
HAN: 110912910 110937378
LSV: 111913826
CCAV: 112507996
DCR: 108202889 108219428
BVG: 104884065 104884652
SOE: 110794643
CQI: 110734009 110737800
NNU: 104607825
PSOM: 113283309 113356237
OSA: 4336813
DOSA: Os04t0589600-01(Os04g0589600)
OBR: 102720873
BDI: 100838439
ATS: 109741247(LOC109741247)
SBI: 8060461
ZMA: 100279297(csu425(gct))
SITA: 101773290 101779913 101784521
PDA: 103696780
EGU: 105033909 105043944
MUS: 103983835
DCT: 110094921
PEQ: 110034058
AOF: 109825622 109826114
ATR: 18445550
SMO: SELMODRAFT_419620(GT4A5)
PPP: 112289303
CRE: CHLREDRAFT_122195(GTR5)
VCN: VOLCADRAFT_67522
MNG: MNEG_12470
CSL: COCSUDRAFT_12084
CVR: CHLNCDRAFT_56004
APRO: F751_4445
OLU: OSTLU_119517(alg2)
OTA: OT_ostta02g00860
BPG: Bathy14g01700(ALG2)
MIS: MICPUN_113380
MPP: MICPUCDRAFT_70800
CME: CYME_CMT168C
GSL: Gasu_57500
CCP: CHC_T00007099001
SCE: YGL065C(ALG2)
AGO: AGOS_AFL098W
ERC: Ecym_2197
KLA: KLLA0_B02420g
KMX: KLMA_40539(ALG2)
LTH: KLTH0H04070g
VPO: Kpol_1002p49
ZRO: ZYRO0C13354g
CGR: CAGL0M05731g
NCS: NCAS_0D04140(NCAS0D04140)
NDI: NDAI_0I00780(NDAI0I00780)
TPF: TPHA_0J02410(TPHA0J02410)
TBL: TBLA_0B05350(TBLA0B05350)
TDL: TDEL_0E05270(TDEL0E05270)
KAF: KAFR_0K02320(KAFR0K02320)
PPA: PAS_c121_0002
DHA: DEHA2C04158g
PIC: PICST_89290(ALG2)
PGU: PGUG_05778
SPAA: SPAPADRAFT_52552
LEL: LELG_04866
CAL: CAALFM_C604030WA(ALG2)
CTP: CTRG_02748
COT: CORT_0F02370
CDU: CD36_64500
CTEN: CANTEDRAFT_115508
YLI: YALI0E31797g
CLU: CLUG_05086
CLUS: A9F13_03g01507
CAUR: CJI97_003788
SLB: AWJ20_2865(ALG2)
PKZ: C5L36_0B10400
NCR: NCU03503(cot-5)
NTE: NEUTE1DRAFT66075(NEUTE1DRAFT_66075)
SMP: SMAC_07237
PAN: PODANSg6988
TTT: THITE_2123138
MTM: MYCTH_2311469
CTHR: CTHT_0007110
MGR: MGG_02384
TMN: UCRPA7_8209
SSCK: SPSK_04214
FGR: FGSG_01640
FPU: FPSE_09750
FVR: FVEG_09738
FOX: FOXG_11063
NHE: NECHADRAFT_30261
TRE: TRIREDRAFT_70035
TRR: M419DRAFT_91331
MAW: MAC_05793
MAJ: MAA_08596
CMT: CCM_02067
PLJ: VFPFJ_07403
VAL: VDBG_05501
VDA: VDAG_07149
CFJ: CFIO01_09218
SAPO: SAPIO_CDS1116
ELA: UCREL1_2618
PFY: PFICI_09278
SSL: SS1G_02473
BFU: BCIN_13g03800(Bcalg2)
MBE: MBM_06396
PSCO: LY89DRAFT_574121
GLZ: GLAREA_11972
ANI: AN6874.2
AFM: AFUA_5G13210
ACT: ACLA_016180
NFI: NFIA_073820
AOR: AO090120000461
ANG: ANI_1_1548124(An14g05910)
AFV: AFLA_094350
PCS: Pc21g07970
PDP: PDIP_59020
TMF: PMAA_035970
CIM: CIMG_09741
CPW: CPC735_023190
PBL: PAAG_05192
PBN: PADG_05063
URE: UREG_04663
ABE: ARB_02714
TVE: TRV_05563
AJE: HCAG_00318
BGH: BDBG_01580
PNO: SNOG_14088
PTE: PTT_03994
BZE: COCCADRAFT_109937
BSC: COCSADRAFT_32523
BOR: COCMIDRAFT_81095
AALT: CC77DRAFT_941333
ZTR: MYCGRDRAFT_75289(Mg61467)
PFJ: MYCFIDRAFT_190600
BCOM: BAUCODRAFT_311273
NPA: UCRNP2_5009
TML: GSTUM_00001241001
SPO: SPBC11B10.01(alg2)
CNE: CND00660
CNB: CNBD5610
CGI: CGB_J1620C
TMS: TREMEDRAFT_74186 TREMEDRAFT_74187
TASA: A1Q1_01692
TVS: TRAVEDRAFT_46179
DSQ: DICSQDRAFT_146404
PCO: PHACADRAFT_122257
SHS: STEHIDRAFT_84779
HIR: HETIRDRAFT_146079
PSQ: PUNSTDRAFT_70194
ADL: AURDEDRAFT_80935
GTR: GLOTRDRAFT_141423
LBC: LACBIDRAFT_247825(ALG2)
MPR: MPER_07727
MRR: Moror_12356
CCI: CC1G_04804
SCM: SCHCODRAFT_58094
ABP: AGABI1DRAFT125635(AGABI1DRAFT_125635)
ABV: AGABI2DRAFT65105(AGABI2DRAFT_65105)
CPUT: CONPUDRAFT_118510
SLA: SERLADRAFT_474957
WSE: WALSEDRAFT_59654
WIC: J056_002368
UMA: UMAG_02653
PFP: PFL1_03826
MGL: MGL_1050
MRT: MRET_3105
MSYM: MSY001_0809(ALG2)
PGR: PGTG_20272 PGTG_21912
MLR: MELLADRAFT_42497
SRE: PTSG_07164
DDI: DDB_G0272730(alg2)
DPP: DICPUDRAFT_88372
DFA: DFA_05987(alg2)
EHI: EHI_001990(90.t00023)
EDI: EDI_074330 EDI_138820
EIV: EIN_313420
ACAN: ACA1_360020
CPV: cgd1_230
CHO: Chro.10033
TGO: TGME49_227790
TET: TTHERM_00335960
PTM: GSPATT00017608001
PTI: PHATRDRAFT_22554
FCY: FRACYDRAFT_158588
TPS: THAPS_263193
NGD: NGA_2082800(ALG2)
AAF: AURANDRAFT_29980
SPAR: SPRG_01564
GTT: GUITHDRAFT_74012
TBR: Tb927.4.2230
TBG: TbgDal_IV2190
TCR: 506559.420
LMA: LMJF_34_2420
LIF: LINJ_34_2190
LDO: LDBPK_342190
LMI: LMXM_33_2420
LBZ: LBRM_20_1920
LPAN: LPMP_202100
NGR: NAEGRDRAFT_32499
TVA: TVAG_372200
AMC: MADE_1008265
WBA: UR17_C0001G0513(alg2)
 » show all
Reference
  Authors
Thiel C, Schwarz M, Peng J, Grzmil M, Hasilik M, Braulke T, Kohlschutter A, von Figura K, Lehle L, Korner C.
  Title
A new type of congenital disorders of glycosylation (CDG-Ii) provides new insights into the early steps of dolichol-linked oligosaccharide biosynthesis.
  Journal
J Biol Chem 278:22498-505 (2003)
DOI:10.1074/jbc.M302850200
  Sequence
[hsa:85365] [sce:YGL065C]

  All links  
Ontology (4)   
   KEGG BRITE (3)   
   CAZY (1)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Disease (2)   
   KEGG DISEASE (2)   
Chemical reaction (4)   
   KEGG ENZYME (2)   
   KEGG REACTION (2)   
Gene (3478)   
   KEGG GENES (557)   
   KEGG MGENES (560)   
   RefGene (2357)   
   OC (4)   
Protein sequence (314)   
   UniProt (302)   
   SWISS-PROT (12)   
Literature (1)   
   PubMed (1)   
All databases (3810)   

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KEGG   ENZYME: 2.4.1.132
Entry
EC 2.4.1.132                Enzyme                                 

Name
GDP-Man:Man1GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase;
Alg2 mannosyltransferase (ambiguous);
ALG2 (gene name, ambiguous);
glycolipid 3-alpha-mannosyltransferase;
GDP-mannose:glycolipid 3-alpha-D-mannosyltransferase;
GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase;
GDP-D-mannose:D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 3-alpha-mannosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-alpha-D-mannose:beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol 3-alpha-D-mannosyltransferase (configuration-retaining)
Reaction(IUBMB)
GDP-alpha-D-mannose + beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = GDP + alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol [RN:R05002 R05973]
Reaction(KEGG)
R05002 R05973(G)
Substrate
GDP-alpha-D-mannose [CPD:C00096];
beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
Product
GDP [CPD:C00035];
alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
Comment
The biosynthesis of asparagine-linked glycoproteins utilizes a dolichyl diphosphate-linked glycosyl donor, which is assembled by the series of membrane-bound glycosyltransferases that comprise the dolichol pathway. Alg2 mannosyltransferase from Saccharomyces cerevisiae carries out an alpha1,3-mannosylation of D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol, followed by an alpha1,6-mannosylation (cf. EC 2.4.1.257), to form the first branched pentasaccharide intermediate of the dolichol pathway [1,2].
History
EC 2.4.1.132 created 1984, modified 2011, modified 2012
Pathway
ec00510  N-Glycan biosynthesis
ec00513  Various types of N-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K03843  alpha-1,3/alpha-1,6-mannosyltransferase
Genes
HSA: 85365(ALG2)
PTR: 472993(ALG2)
PPS: 100984805(ALG2)
GGO: 101128869(ALG2)
PON: 100451740(ALG2)
NLE: 100593183(ALG2)
MCC: 714850(ALG2)
MCF: 102146841(ALG2)
CSAB: 103219138(ALG2)
RRO: 104657764(ALG2)
RBB: 108512462(ALG2)
CJC: 100388149(ALG2)
SBQ: 101030903(ALG2)
MMU: 56737(Alg2)
MCAL: 110292619(Alg2)
MPAH: 110323013(Alg2)
RNO: 313231(Alg2)
MUN: 110556433 110556434
CGE: 100768412(Alg2)
NGI: 103749080(Alg2)
HGL: 101717738(Alg2)
CCAN: 109691420(Alg2)
OCU: 100353637(ALG2)
TUP: 102477233(ALG2)
CFA: 474780(ALG2)
VVP: 112930771(ALG2)
AML: 100471257(ALG2)
UMR: 103678628(ALG2)
UAH: 113260403(ALG2)
ORO: 101379758(ALG2)
ELK: 111145785
FCA: 101084066(ALG2)
PTG: 102963679(ALG2)
PPAD: 109270077(ALG2)
AJU: 106972044(ALG2)
BTA: 538899(ALG2)
BOM: 102282554(ALG2)
BIU: 109563080(ALG2)
BBUB: 102397326(ALG2)
CHX: 102172999(ALG2)
OAS: 101101953(ALG2)
SSC: 100113423(ALG2)
CFR: 102523932(ALG2)
CDK: 105086888(ALG2)
BACU: 102999901(ALG2)
LVE: 103071670(ALG2)
OOR: 101287811(ALG2)
DLE: 111188084(ALG2)
PCAD: 102982177(ALG2)
ECB: 100054840(ALG2)
EPZ: 103555265(ALG2)
EAI: 106842922(ALG2)
MYB: 102241662(ALG2)
MYD: 102764897(ALG2)
MNA: 107544878(ALG2)
HAI: 109386428(ALG2)
DRO: 112304450(ALG2)
PALE: 102880508(ALG2)
RAY: 107500590(ALG2)
MJV: 108394149(ALG2)
LAV: 100655996(ALG2)
TMU: 101352514
MDO: 100011371(ALG2)
SHR: 100913580(ALG2)
PCW: 110214538(ALG2)
OAA: 100092424(ALG2)
GGA: 420998(ALG2)
MGP: 100538726(ALG2)
CJO: 107309970(ALG2)
NMEL: 110393668(ALG2)
APLA: 101795871(ALG2)
ACYG: 106035960(ALG2)
TGU: 100190655(ALG2)
LSR: 110469741(ALG2)
SCAN: 103826142(ALG2)
GFR: 102032538(ALG2)
FAB: 101820728(ALG2)
PHI: 102103653(ALG2)
PMAJ: 107200761(ALG2)
CCAE: 111925280(ALG2)
CCW: 104685901(ALG2)
ETL: 114058961(ALG2)
FPG: 101912340(ALG2)
FCH: 102058016(ALG2)
CLV: 102093093(ALG2)
EGZ: 104130440(ALG2)
NNI: 104018204(ALG2)
ACUN: 113477198(ALG2)
PADL: 103917756(ALG2)
AAM: 106496984(ALG2)
ASN: 102370298(ALG2)
AMJ: 102564853(ALG2)
PSS: 102460786(ALG2)
CMY: 102940919
CPIC: 101942628(ALG2)
ACS: 103279177(alg2)
PVT: 110086078(ALG2)
PBI: 103051382(ALG2)
PMUR: 107291673(ALG2)
TSR: 106538359(ALG2)
PMUA: 114582036(ALG2)
GJA: 107110593(ALG2)
XLA: 446622(alg2.L)
XTR: 595052(alg2)
NPR: 108797276(ALG2)
DRE: 403068(alg2)
SRX: 107706186 107706481 107723517
SANH: 107657723 107687815
SGH: 107593685 107595974
IPU: 108256665(alg2)
PHYP: 113532962(alg2)
AMEX: 103028771(alg2)
EEE: 113590840(alg2)
TRU: 101076494(alg2)
TNG: GSTEN00034041G001
LCO: 104923022(alg2)
NCC: 104966077(alg2)
MZE: 101484363(alg2)
ONL: 100701749(alg2)
OLA: 101167069(alg2)
XMA: 102222028(alg2)
XCO: 114141939(alg2)
PRET: 103478647(alg2)
CVG: 107102914(alg2)
NFU: 107379741(alg2)
KMR: 108241118(alg2)
ALIM: 106527090(alg2)
AOCE: 111577777(alg2)
CSEM: 103388137(alg2)
POV: 109633440(alg2)
LCF: 108889631(alg2)
SDU: 111236927(alg2)
SLAL: 111650852(alg2)
HCQ: 109515460(alg2)
BPEC: 110171549(alg2)
MALB: 109964158(alg2)
SASA: 106574526 106606060
OTW: 112240345(alg2)
SALP: 112076465(alg2)
ELS: 105018904(alg2)
SFM: 108940512(alg2)
PKI: 111845856(alg2)
LCM: 102353262(ALG2)
CMK: 103181173(alg2)
BFO: BRAFLDRAFT_70178
CIN: 100180226
SPU: 115928701 589943
APLC: 110977698
SKO: 100371989
DME: Dmel_CG1291(Alg2)
DER: 6543647
DSE: 6610565
DSI: Dsimw501_GD13727(Dsim_GD13727)
DYA: Dyak_GE20359
DAN: 6506901
DSR: 110182775
DPO: Dpse_GA11900
DPE: 113566407
DMN: 108151759
DWI: 6646055
DGR: Dgri_GH15819
DMO: Dmoj_GI12600
DAZ: 108613374
DNV: 108651329
DHE: 111591933
DVI: 6623162
MDE: 101891935
LCQ: 111680696
AGA: AgaP_AGAP001232
AAG: 5575716
AALB: 109431792
AME: 551972
BIM: 100740485
BTER: 100647541
CCAL: 108626003
OBB: 114878353
SOC: 105207380
MPHA: 105838058
AEC: 105149006
ACEP: 105622020
PBAR: 105433355
VEM: 105565242
HST: 105192054
DQU: 106751846
CFO: 105249015
LHU: 105679897
PGC: 109862973
OBO: 105288046
PCF: 106784395
NVI: 100122589
CSOL: 105367225
MDL: 103576080
TCA: 657332
DPA: 109544912 109546697
ATD: 109601758 109607356
NVL: 108560004 108560581
BMOR: 101737122
BMAN: 114250453
DPL: KGM_212052
PMAC: 106707690
PRAP: 110992446
HAW: 110376252
TNL: 113499527
PXY: 105390412
API: 100164916
DNX: 107167633
AGS: 114128688
RMD: 113547805
BTAB: 109044497
CLEC: 106662501
PHU: Phum_PHUM599360
ZNE: 110826715
FCD: 110848787
DPX: DAPPUDRAFT_192054
PVM: 113807059
ISC: IscW_ISCW008177
TUT: 107361675
DPTE: 113792811
CSCU: 111618264 111618267
PTEP: 107448020
CEL: CELE_F09E5.2(algn-2)
CBR: CBG02380
BMY: Bm1_01370
LOA: LOAG_01337 LOAG_02361
NAI: NECAME_06664
TSP: Tsp_11159 Tsp_11653
HRO: HELRODRAFT_110729
LGI: LOTGIDRAFT_224255
PCAN: 112574345
CRG: 105336633
MYI: 110458513
OBI: 106873336
LAK: 106155289 106164980
SMM: Smp_177080
SHX: MS3_01525
OVI: T265_04788
EGL: EGR_09601
NVE: 5517178
EPA: 110235219
ADF: 107335169
AMIL: 114952865
SPIS: 111340459
DGT: 114533068 114534204
HMG: 101238397
AQU: 100632336
ATH: AT1G78800
ALY: 9325273
CRB: 17894620
CSAT: 104703214 104752305
EUS: EUTSA_v10007837mg EUTSA_v10019736mg
BRP: 103832355
BNA: 106354674
BOE: 106298287
THJ: 104812317
CPAP: 110812537
CIT: 102626306
CIC: CICLE_v10020399mg
TCC: 18594241
GRA: 105777281
GHI: 107917782 107944455
GAB: 108480381
DZI: 111275922 111275924
EGR: 104448547
GMX: 100800839 100809168
GSJ: 114373873 114379181
PVU: PHAVU_005G081600g
VRA: 106778117
VAR: 108321952
VUN: 114183384
CCAJ: 109811934
MTR: MTR_1g104880
CAM: 101501052
ADU: 107458069 107459779
AIP: 107609313 107613290
LANG: 109348100 109357267
FVE: 101292974
RCN: 112165984
PPER: 18778069 18779540
PMUM: 103328865 103342728
PAVI: 110754544 110771820
MDM: 103448776
PXB: 103934886
ZJU: 107403902 107432555
CSV: 101211733 101222455
CMO: 103492951
MCHA: 111012924
CMAX: 111480394
CMOS: 111447959
CPEP: 111781399
RCU: 8276386
JCU: 105637031
HBR: 110670322 110670335 110671298
MESC: 110612091
POP: 7472343
PEU: 105139363
JRE: 109012141
QSU: 111995463 112000262 112040101
VVI: 100248737
SLY: 101245960
SPEN: 107021358
SOT: 102603181
CANN: 107875413
NTA: 107792493 107828501
NSY: 104220522
NTO: 104117000
NAU: 109211705 109228734
INI: 109163384 109175932
SIND: 105176930
OEU: 111370834 111395563
HAN: 110912910 110937378
LSV: 111913826
CCAV: 112507996
DCR: 108202889 108219428
BVG: 104884065 104884652
SOE: 110794643
CQI: 110734009 110737800
NNU: 104607825
PSOM: 113283309 113356237
OSA: 4336813
DOSA: Os04t0589600-01(Os04g0589600)
OBR: 102720873
BDI: 100838439
ATS: 109741247(LOC109741247)
SBI: 8060461
ZMA: 100279297(csu425(gct))
SITA: 101773290 101779913 101784521
PDA: 103696780
EGU: 105033909 105043944
MUS: 103983835
DCT: 110094921
PEQ: 110034058
AOF: 109825622 109826114
ATR: 18445550
SMO: SELMODRAFT_419620(GT4A5)
PPP: 112289303
CRE: CHLREDRAFT_122195(GTR5)
VCN: VOLCADRAFT_67522
MNG: MNEG_12470
CSL: COCSUDRAFT_12084
CVR: CHLNCDRAFT_56004
APRO: F751_4445
OLU: OSTLU_119517(alg2)
OTA: OT_ostta02g00860
BPG: Bathy14g01700(ALG2)
MIS: MICPUN_113380
MPP: MICPUCDRAFT_70800
CME: CYME_CMT168C
GSL: Gasu_57500
CCP: CHC_T00007099001
SCE: YGL065C(ALG2)
AGO: AGOS_AFL098W
ERC: Ecym_2197
KLA: KLLA0_B02420g
KMX: KLMA_40539(ALG2)
LTH: KLTH0H04070g
VPO: Kpol_1002p49
ZRO: ZYRO0C13354g
CGR: CAGL0M05731g
NCS: NCAS_0D04140(NCAS0D04140)
NDI: NDAI_0I00780(NDAI0I00780)
TPF: TPHA_0J02410(TPHA0J02410)
TBL: TBLA_0B05350(TBLA0B05350)
TDL: TDEL_0E05270(TDEL0E05270)
KAF: KAFR_0K02320(KAFR0K02320)
PPA: PAS_c121_0002
DHA: DEHA2C04158g
PIC: PICST_89290(ALG2)
PGU: PGUG_05778
SPAA: SPAPADRAFT_52552
LEL: LELG_04866
CAL: CAALFM_C604030WA(ALG2)
CTP: CTRG_02748
COT: CORT_0F02370
CDU: CD36_64500
CTEN: CANTEDRAFT_115508
YLI: YALI0E31797g
CLU: CLUG_05086
CLUS: A9F13_03g01507
CAUR: CJI97_003788
SLB: AWJ20_2865(ALG2)
PKZ: C5L36_0B10400
NCR: NCU03503(cot-5)
NTE: NEUTE1DRAFT66075(NEUTE1DRAFT_66075)
SMP: SMAC_07237
PAN: PODANSg6988
TTT: THITE_2123138
MTM: MYCTH_2311469
CTHR: CTHT_0007110
MGR: MGG_02384
TMN: UCRPA7_8209
SSCK: SPSK_04214
FGR: FGSG_01640
FPU: FPSE_09750
FVR: FVEG_09738
FOX: FOXG_11063
NHE: NECHADRAFT_30261
TRE: TRIREDRAFT_70035
TRR: M419DRAFT_91331
MAW: MAC_05793
MAJ: MAA_08596
CMT: CCM_02067
PLJ: VFPFJ_07403
VAL: VDBG_05501
VDA: VDAG_07149
CFJ: CFIO01_09218
SAPO: SAPIO_CDS1116
ELA: UCREL1_2618
PFY: PFICI_09278
SSL: SS1G_02473
BFU: BCIN_13g03800(Bcalg2)
MBE: MBM_06396
PSCO: LY89DRAFT_574121
GLZ: GLAREA_11972
ANI: AN6874.2
AFM: AFUA_5G13210
ACT: ACLA_016180
NFI: NFIA_073820
AOR: AO090120000461
ANG: ANI_1_1548124(An14g05910)
AFV: AFLA_094350
PCS: Pc21g07970
PDP: PDIP_59020
TMF: PMAA_035970
CIM: CIMG_09741
CPW: CPC735_023190
PBL: PAAG_05192
PBN: PADG_05063
URE: UREG_04663
ABE: ARB_02714
TVE: TRV_05563
AJE: HCAG_00318
BGH: BDBG_01580
PNO: SNOG_14088
PTE: PTT_03994
BZE: COCCADRAFT_109937
BSC: COCSADRAFT_32523
BOR: COCMIDRAFT_81095
AALT: CC77DRAFT_941333
ZTR: MYCGRDRAFT_75289(Mg61467)
PFJ: MYCFIDRAFT_190600
BCOM: BAUCODRAFT_311273
NPA: UCRNP2_5009
TML: GSTUM_00001241001
SPO: SPBC11B10.01(alg2)
CNE: CND00660
CNB: CNBD5610
CGI: CGB_J1620C
TMS: TREMEDRAFT_74186 TREMEDRAFT_74187
TASA: A1Q1_01692
TVS: TRAVEDRAFT_46179
DSQ: DICSQDRAFT_146404
PCO: PHACADRAFT_122257
SHS: STEHIDRAFT_84779
HIR: HETIRDRAFT_146079
PSQ: PUNSTDRAFT_70194
ADL: AURDEDRAFT_80935
GTR: GLOTRDRAFT_141423
LBC: LACBIDRAFT_247825(ALG2)
MPR: MPER_07727
MRR: Moror_12356
CCI: CC1G_04804
SCM: SCHCODRAFT_58094
ABP: AGABI1DRAFT125635(AGABI1DRAFT_125635)
ABV: AGABI2DRAFT65105(AGABI2DRAFT_65105)
CPUT: CONPUDRAFT_118510
SLA: SERLADRAFT_474957
WSE: WALSEDRAFT_59654
WIC: J056_002368
UMA: UMAG_02653
PFP: PFL1_03826
MGL: MGL_1050
MRT: MRET_3105
MSYM: MSY001_0809(ALG2)
PGR: PGTG_20272 PGTG_21912
MLR: MELLADRAFT_42497
SRE: PTSG_07164
DDI: DDB_G0272730(alg2)
DPP: DICPUDRAFT_88372
DFA: DFA_05987(alg2)
EHI: EHI_001990(90.t00023)
EDI: EDI_074330 EDI_138820
EIV: EIN_313420
ACAN: ACA1_360020
CPV: cgd1_230
CHO: Chro.10033
TGO: TGME49_227790
TET: TTHERM_00335960
PTM: GSPATT00017608001
PTI: PHATRDRAFT_22554
FCY: FRACYDRAFT_158588
TPS: THAPS_263193
NGD: NGA_2082800(ALG2)
AAF: AURANDRAFT_29980
SPAR: SPRG_01564
GTT: GUITHDRAFT_74012
TBR: Tb927.4.2230
TBG: TbgDal_IV2190
TCR: 506559.420
LMA: LMJF_34_2420
LIF: LINJ_34_2190
LDO: LDBPK_342190
LMI: LMXM_33_2420
LBZ: LBRM_20_1920
LPAN: LPMP_202100
NGR: NAEGRDRAFT_32499
TVA: TVAG_372200
AMC: MADE_1008265
WBA: UR17_C0001G0513(alg2)
 » show all
Reference
1  [PMID:19282279]
  Authors
Kampf M, Absmanner B, Schwarz M, Lehle L
  Title
Biochemical characterization and membrane topology of Alg2 from Saccharomyces cerevisiae as a bifunctional alpha1,3- and 1,6-mannosyltransferase involved in lipid-linked oligosaccharide biosynthesis.
  Journal
J Biol Chem 284:11900-12 (2009)
DOI:10.1074/jbc.M806416200
Reference
2  [PMID:16878994]
  Authors
O'Reilly MK, Zhang G, Imperiali B
  Title
In vitro evidence for the dual function of Alg2 and Alg11: essential mannosyltransferases in N-linked glycoprotein biosynthesis.
  Journal
Biochemistry 45:9593-603 (2006)
DOI:10.1021/bi060878o
  Sequence
[sce:YGL065C]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.132
IUBMB Enzyme Nomenclature: 2.4.1.132
ExPASy - ENZYME nomenclature database: 2.4.1.132
BRENDA, the Enzyme Database: 2.4.1.132
CAS: 81181-76-2

  All links  
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (4)   
   KEGG GLYCAN (4)   
Chemical reaction (4)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Gene (3475)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (557)   
   KEGG MGENES (560)   
   RefGene (2357)   
Protein sequence (85)   
   UniProt (55)   
   SWISS-PROT (13)   
   RefSeq(pep) (17)   
DNA sequence (78)   
   RefSeq(nuc) (31)   
   GenBank (32)   
   EMBL (15)   
Protein domain (3)   
   InterPro (3)   
All databases (3660)   

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KEGG   REACTION: R05973
Entry
R05973                      Reaction                               

Definition
GDP-D-mannose + G00003 <=> GDP + G00004
Equation
Remark
Same as: R05002
Enzyme
Pathway
rn00510  N-Glycan biosynthesis
rn00513  Various types of N-glycan biosynthesis
rn01100  Metabolic pathways
Module
M00055  N-glycan precursor biosynthesis
Orthology
K03843  alpha-1,3/alpha-1,6-mannosyltransferase [EC:2.4.1.132 2.4.1.257]
Other DBs
RHEA: 29518

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (4)   
   KEGG GLYCAN (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (558)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (557)   
All databases (572)   

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