KEGG   ORTHOLOGY: K03845
Entry
K03845                      KO                                     

Name
ALG3
Definition
alpha-1,3-mannosyltransferase [EC:2.4.1.258]
Pathway
ko00510  N-Glycan biosynthesis
ko00513  Various types of N-glycan biosynthesis
ko01100  Metabolic pathways
Module
M00055  N-glycan precursor biosynthesis
Disease
H00118  Congenital disorders of glycosylation type I
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00510 N-Glycan biosynthesis
    K03845  ALG3; alpha-1,3-mannosyltransferase
   00513 Various types of N-glycan biosynthesis
    K03845  ALG3; alpha-1,3-mannosyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K03845  ALG3; alpha-1,3-mannosyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.258  dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase
     K03845  ALG3; alpha-1,3-mannosyltransferase
Glycosyltransferases [BR:ko01003]
 N-Glycan biosynthesis
  Dol-linked oligosaccharide
   K03845  ALG3; alpha-1,3-mannosyltransferase
Other DBs
RN: R06258
GO: 0000033 0004584
CAZy: GT58
Genes
HSA: 10195(ALG3)
PTR: 460886(ALG3)
PPS: 100979287(ALG3)
GGO: 101148766(ALG3)
PON: 100448751(ALG3)
NLE: 100581760(ALG3)
MCC: 703087(ALG3)
MCF: 102134126(ALG3)
CSAB: 103221139(ALG3)
RRO: 104664632(ALG3)
RBB: 108524997(ALG3)
CJC: 100390805(ALG3)
SBQ: 101045776(ALG3)
MMU: 208624(Alg3)
MCAL: 110311374(Alg3)
MPAH: 110330167(Alg3)
RNO: 287983(Alg3)
MUN: 110549394(Alg3)
CGE: 100772003(Alg3)
NGI: 103732650(Alg3)
HGL: 101714764(Alg3)
CCAN: 109694096(Alg3)
OCU: 100358108(ALG3)
TUP: 102473222(ALG3)
CFA: 478653(ALG3)
VVP: 112926262(ALG3)
AML: 100472334(ALG3)
UMR: 103676182(ALG3)
UAH: 113254352(ALG3)
ORO: 101377982(ALG3)
ELK: 111150611
FCA: 101087681(ALG3)
PTG: 102971503(ALG3)
PPAD: 109275223(ALG3)
AJU: 106983810(ALG3)
BTA: 614624(ALG3)
BOM: 102285313(ALG3)
BIU: 109557412(ALG3)
BBUB: 102402457(ALG3)
CHX: 102181899(ALG3)
OAS: 101121650(ALG3)
SSC: 100627022(ALG3)
CFR: 102504086(ALG3)
CDK: 105085886(ALG3)
BACU: 103005524(ALG3)
LVE: 103084099(ALG3)
OOR: 101272032(ALG3)
DLE: 111173360(ALG3)
PCAD: 102996118(ALG3)
ECB: 100059007(ALG3)
EPZ: 103554746(ALG3)
EAI: 106834523(ALG3)
MYB: 102241054(ALG3)
MYD: 102766472(ALG3)
MNA: 107541086(ALG3)
HAI: 109396699(ALG3)
DRO: 112305128(ALG3)
PALE: 102890134(ALG3)
RAY: 107504920(ALG3)
MJV: 108395266(ALG3)
LAV: 100674341(ALG3)
TMU: 101360342
MDO: 100025876(ALG3)
SHR: 100932630(ALG3)
PCW: 110221182(ALG3)
OAA: 100681362(ALG3)
GGA: 424952(ALG3)
MGP: 100543165(ALG3)
CJO: 107318207(ALG3)
NMEL: 110397801(ALG3)
APLA: 101791055(ALG3)
ACYG: 106032204(ALG3)
TGU: 100230731(ALG3)
LSR: 110477428(ALG3)
SCAN: 103815608(ALG3)
GFR: 102039749(ALG3)
FAB: 101819823(ALG3)
PHI: 102102878(ALG3)
PMAJ: 107208518(ALG3)
CCAE: 111933602(ALG3)
CCW: 104688139(ALG3)
ETL: 114060771(ALG3)
FPG: 101916756(ALG3)
FCH: 102050162(ALG3)
CLV: 102094667(ALG3)
EGZ: 104122229(ALG3)
NNI: 104015704(ALG3)
ACUN: 113483436(ALG3)
AAM: 106500262(ALG3)
ASN: 102369785(ALG3)
AMJ: 102560066(ALG3)
PSS: 102457770(ALG3)
CMY: 102937300(ALG3)
CPIC: 101941423(ALG3)
ACS: 100561775(alg3)
PVT: 110091600(ALG3)
PBI: 103048200(ALG3)
PMUR: 107294401(ALG3)
TSR: 106552359(ALG3)
PMUA: 114598066(ALG3)
GJA: 107123667(ALG3)
XLA: 100037243(alg3.S)
XTR: 100127746(alg3)
NPR: 108804700(ALG3)
DRE: 553725(alg3)
CCAR: 109063669(alg3)
IPU: 108280746(alg3)
PHYP: 113533332(alg3)
AMEX: 103037087(alg3)
EEE: 113568455(alg3)
TRU: 101070707(alg3)
LCO: 104935094(alg3)
NCC: 104957796(alg3)
MZE: 101479101(alg3)
ONL: 100699348(alg3)
OLA: 101167399(alg3)
XMA: 102230775(alg3)
XCO: 114147052(alg3)
PRET: 103479375(alg3)
CVG: 107101045(alg3)
NFU: 107384062(alg3)
KMR: 108239541(alg3)
ALIM: 106528976(alg3)
AOCE: 111582584(alg3)
CSEM: 103395988(alg3)
POV: 109645187(alg3)
LCF: 108883543(alg3)
SDU: 111229092(alg3)
SLAL: 111654479(alg3)
HCQ: 109524102(alg3)
BPEC: 110158566(alg3)
MALB: 109957667(alg3)
SASA: 106600580(alg3)
ELS: 105021055(alg3)
SFM: 108935289(alg3)
PKI: 111847388(alg3)
LCM: 102361691(ALG3)
CMK: 103182887(alg3)
RTP: 109916296(alg3)
CIN: 100176327
SPU: 576672
APLC: 110978953
SKO: 100370088
DME: Dmel_CG4084(Alg3)
DER: 6547893
DSE: 6615760
DSI: Dsimw501_GD25022(Dsim_GD25022)
DAN: 6494688
DSR: 110176926
DPE: 6593024
DMN: 108158679
DWI: 6652196
DAZ: 108616984
DNV: 108654695
DHE: 111599911
MDE: 101887633
LCQ: 111680079
AAG: 5574793
AALB: 109415735
AME: 724399
BIM: 100740988
BTER: 100643648
CCAL: 113464335
OBB: 114873283
SOC: 105199092
MPHA: 105833095
AEC: 105152598
ACEP: 105617243
PBAR: 105433742
VEM: 105563964
HST: 105182205
DQU: 106748045
CFO: 105251420
LHU: 105668510
PGC: 109859340
OBO: 105280429
PCF: 106784472
NVI: 100115752
CSOL: 105360913
MDL: 103575039
TCA: 655451
DPA: 109539990
ATD: 109600158
NVL: 108558978
BMOR: 101741427
BMAN: 114241636
PMAC: 106712323
PRAP: 111002964
HAW: 110384151
TNL: 113492747
API: 103308067
DNX: 107172979
AGS: 114129907
RMD: 113554562
BTAB: 109033224
CLEC: 106663453
ZNE: 110833535
FCD: 110846318
PVM: 113822625
DPTE: 113791018
CSCU: 111622730
PTEP: 107456683
CEL: CELE_K09E4.2(algn-3)
CBR: CBG20997
TSP: Tsp_08712
PCAN: 112557649
CRG: 105346658
OBI: 106874294
LAK: 106174922
SHX: MS3_09308
NVE: 5518637
EPA: 110251455
ADF: 107332168
AMIL: 114965518
PDAM: 113686199
SPIS: 111328572
DGT: 114518083
HMG: 100214877
ATH: AT2G47760(ALG3)
ALY: 9318197
CRB: 17890265
BRP: 103866347
BOE: 106337396
RSZ: 108813443
THJ: 104802172
CPAP: 110821460
CIT: 102617688
TCC: 18613533
GRA: 105762674
DZI: 111314136
EGR: 104456792
VRA: 106758012
VAR: 108329708
VUN: 114186261
CCAJ: 109812263
CAM: 101509815
LJA: Lj1g3v4899050.1(Lj1g3v4899050.1)
ADU: 107492492
AIP: 107645621
FVE: 101310494
RCN: 112172534
PPER: 18767523
PMUM: 103333910
PAVI: 110761861
ZJU: 107426367
CSV: 101211394
CMO: 103492832
MCHA: 111020823
CMAX: 111488806
CMOS: 111456562
CPEP: 111807027
RCU: 8271753
JCU: 105642496
HBR: 110660934
MESC: 110615603
POP: 7457948
PEU: 105132014
VVI: 100253790
SLY: 101251511
SPEN: 107029293
SOT: 102598887
CANN: 107864015
NSY: 104225504
NTO: 104099176
INI: 109160269
SIND: 105165232
OEU: 111394355
HAN: 110895982
LSV: 111917946
CCAV: 112513534
DCR: 108224117
BVG: 104906606
SOE: 110797544
NNU: 104610985
PSOM: 113357561
OSA: 9266078
OBR: 102705966
BDI: 100822122
ATS: 109779517(LOC109779517)
SBI: 8056549
ZMA: 100276684
SITA: 101768406
PDA: 103712729
EGU: 105060271
MUS: 103981289
DCT: 110101639
PEQ: 110026944
AOF: 109841030
ATR: 18430288
SMO: SELMODRAFT_96090(GT58A1)
PPP: 112287567
APRO: F751_3769
SCE: YBL082C(ALG3)
ERC: Ecym_7147
KMX: KLMA_80379(ALG3)
NCS: NCAS_0E02510(NCAS0E02510)
NDI: NDAI_0E04080(NDAI0E04080)
TPF: TPHA_0K00760(TPHA0K00760)
TBL: TBLA_0D00510(TBLA0D00510)
TDL: TDEL_0C02670(TDEL0C02670)
KAF: KAFR_0L01850(KAFR0L01850)
PIC: PICST_58095(RHK1)
CAL: CAALFM_C604340WA(CaO19.1092)
NCR: NCU06552
NTE: NEUTE1DRAFT78420(NEUTE1DRAFT_78420)
MGR: MGG_08010
SSCK: SPSK_09197
MAW: MAC_01438
MAJ: MAA_07040
CMT: CCM_00021
BFU: BCIN_12g04720(Bcalg3)
MBE: MBM_00831
ANI: AN0104.2
ANG: ANI_1_1172164(An18g02360)
ABE: ARB_04378
TVE: TRV_03168
PNO: SNOG_16505(SNOG_16504)
PTE: PTT_10389
SPO: SPAC7D4.06c(alg3)
CNE: CNL04800
CNB: CNBI2040
TASA: A1Q1_00798
LBC: LACBIDRAFT_247511(ALG3)
SCM: SCHCODRAFT_51393(alg3)
ABP: AGABI1DRAFT118456(AGABI1DRAFT_118456)
ABV: AGABI2DRAFT200258(AGABI2DRAFT_200258)
MRT: MRET_3365
MSYM: MSY001_3019(ALG3)
DDI: DDB_G0268238(alg3)
DFA: DFA_10860(alg3)
FCY: FRACYDRAFT_180557(ALG3)
SPAR: SPRG_04773
EHX: EMIHUDRAFT_426313(ALG3-1) EMIHUDRAFT_521974(ALG3-2)
LMA: LMJF_36_2040(ALG3)
LIF: LINJ_36_2160(ALG3)
LPAN: LPMP_352120(ALG3)
 » show all
Reference
  Authors
Henquet M, Lehle L, Schreuder M, Rouwendal G, Molthoff J, Helsper J, van der Krol S, Bosch D
  Title
Identification of the gene encoding the alpha1,3-mannosyltransferase (ALG3) in Arabidopsis and characterization of downstream n-glycan processing.
  Journal
Plant Cell 20:1652-64 (2008)
DOI:10.1105/tpc.108.060731
  Sequence
[ath:AT2G47760]

KEGG   ENZYME: 2.4.1.258
Entry
EC 2.4.1.258                Enzyme                                 

Name
dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase;
Man5GlcNAc2-PP-Dol mannosyltransferase;
ALG3;
dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase;
Not56-like protein;
Alg3 alpha-1,3-mannosyl transferase;
Dol-P-Man:Man5GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase;
dolichyl beta-D-mannosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,3-mannosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
dolichyl beta-D-mannosyl phosphate:alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol 3-alpha-D-mannosyltransferase (configuration-inverting)
Reaction(IUBMB)
dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate [RN:R06258]
Reaction(KEGG)
R06258(G)
Substrate
dolichyl beta-D-mannosyl phosphate [CPD:C03862];
alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
Product
alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol;
dolichyl phosphate [CPD:C00110]
Comment
The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl diphosphate. Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-dolichol to Man9Glc-NAc2-PP-dolichol on the lumenal side use dolichyl beta-D-mannosyl phosphate. The first step of this assembly pathway on the luminal side of the endoplasmic reticulum is catalysed by ALG3.
History
EC 2.4.1.258 created 1976 as EC 2.4.1.130, part transferred 2011 to EC 2.4.1.258, modified 2012
Pathway
ec00510  N-Glycan biosynthesis
ec00513  Various types of N-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K03845  alpha-1,3-mannosyltransferase
Genes
HSA: 10195(ALG3)
PTR: 460886(ALG3)
PPS: 100979287(ALG3)
GGO: 101148766(ALG3)
PON: 100448751(ALG3)
NLE: 100581760(ALG3)
MCC: 703087(ALG3)
MCF: 102134126(ALG3)
CSAB: 103221139(ALG3)
RRO: 104664632(ALG3)
RBB: 108524997(ALG3)
CJC: 100390805(ALG3)
SBQ: 101045776(ALG3)
MMU: 208624(Alg3)
MCAL: 110311374(Alg3)
MPAH: 110330167(Alg3)
RNO: 287983(Alg3)
MUN: 110549394(Alg3)
CGE: 100772003(Alg3)
NGI: 103732650(Alg3)
HGL: 101714764(Alg3)
CCAN: 109694096(Alg3)
OCU: 100358108(ALG3)
TUP: 102473222(ALG3)
CFA: 478653(ALG3)
VVP: 112926262(ALG3)
AML: 100472334(ALG3)
UMR: 103676182(ALG3)
UAH: 113254352(ALG3)
ORO: 101377982(ALG3)
ELK: 111150611
FCA: 101087681(ALG3)
PTG: 102971503(ALG3)
PPAD: 109275223(ALG3)
AJU: 106983810(ALG3)
BTA: 614624(ALG3)
BOM: 102285313(ALG3)
BIU: 109557412(ALG3)
BBUB: 102402457(ALG3)
CHX: 102181899(ALG3)
OAS: 101121650(ALG3)
SSC: 100627022(ALG3)
CFR: 102504086(ALG3)
CDK: 105085886(ALG3)
BACU: 103005524(ALG3)
LVE: 103084099(ALG3)
OOR: 101272032(ALG3)
DLE: 111173360(ALG3)
PCAD: 102996118(ALG3)
ECB: 100059007(ALG3)
EPZ: 103554746(ALG3)
EAI: 106834523(ALG3)
MYB: 102241054(ALG3)
MYD: 102766472(ALG3)
MNA: 107541086(ALG3)
HAI: 109396699(ALG3)
DRO: 112305128(ALG3)
PALE: 102890134(ALG3)
RAY: 107504920(ALG3)
MJV: 108395266(ALG3)
LAV: 100674341(ALG3)
TMU: 101360342
MDO: 100025876(ALG3)
SHR: 100932630(ALG3)
PCW: 110221182(ALG3)
OAA: 100681362(ALG3)
GGA: 424952(ALG3)
MGP: 100543165(ALG3)
CJO: 107318207(ALG3)
NMEL: 110397801(ALG3)
APLA: 101791055(ALG3)
ACYG: 106032204(ALG3)
TGU: 100230731(ALG3)
LSR: 110477428(ALG3)
SCAN: 103815608(ALG3)
GFR: 102039749(ALG3)
FAB: 101819823(ALG3)
PHI: 102102878(ALG3)
PMAJ: 107208518(ALG3)
CCAE: 111933602(ALG3)
CCW: 104688139(ALG3)
ETL: 114060771(ALG3)
FPG: 101916756(ALG3)
FCH: 102050162(ALG3)
CLV: 102094667(ALG3)
EGZ: 104122229(ALG3)
NNI: 104015704(ALG3)
ACUN: 113483436(ALG3)
AAM: 106500262(ALG3)
ASN: 102369785(ALG3)
AMJ: 102560066(ALG3)
PSS: 102457770(ALG3)
CMY: 102937300(ALG3)
CPIC: 101941423(ALG3)
ACS: 100561775(alg3)
PVT: 110091600(ALG3)
PBI: 103048200(ALG3)
PMUR: 107294401(ALG3)
TSR: 106552359(ALG3)
PMUA: 114598066(ALG3)
GJA: 107123667(ALG3)
XLA: 100037243(alg3.S)
XTR: 100127746(alg3)
NPR: 108804700(ALG3)
DRE: 553725(alg3)
CCAR: 109063669(alg3)
IPU: 108280746(alg3)
PHYP: 113533332(alg3)
AMEX: 103037087(alg3)
EEE: 113568455(alg3)
TRU: 101070707(alg3)
LCO: 104935094(alg3)
NCC: 104957796(alg3)
MZE: 101479101(alg3)
ONL: 100699348(alg3)
OLA: 101167399(alg3)
XMA: 102230775(alg3)
XCO: 114147052(alg3)
PRET: 103479375(alg3)
CVG: 107101045(alg3)
NFU: 107384062(alg3)
KMR: 108239541(alg3)
ALIM: 106528976(alg3)
AOCE: 111582584(alg3)
CSEM: 103395988(alg3)
POV: 109645187(alg3)
LCF: 108883543(alg3)
SDU: 111229092(alg3)
SLAL: 111654479(alg3)
HCQ: 109524102(alg3)
BPEC: 110158566(alg3)
MALB: 109957667(alg3)
SASA: 106600580(alg3)
ELS: 105021055(alg3)
SFM: 108935289(alg3)
PKI: 111847388(alg3)
LCM: 102361691(ALG3)
CMK: 103182887(alg3)
RTP: 109916296(alg3)
CIN: 100176327
SPU: 576672
APLC: 110978953
SKO: 100370088
DME: Dmel_CG4084(Alg3)
DER: 6547893
DSE: 6615760
DSI: Dsimw501_GD25022(Dsim_GD25022)
DAN: 6494688
DSR: 110176926
DPE: 6593024
DMN: 108158679
DWI: 6652196
DAZ: 108616984
DNV: 108654695
DHE: 111599911
MDE: 101887633
LCQ: 111680079
AAG: 5574793
AALB: 109415735
AME: 724399
BIM: 100740988
BTER: 100643648
CCAL: 113464335
OBB: 114873283
SOC: 105199092
MPHA: 105833095
AEC: 105152598
ACEP: 105617243
PBAR: 105433742
VEM: 105563964
HST: 105182205
DQU: 106748045
CFO: 105251420
LHU: 105668510
PGC: 109859340
OBO: 105280429
PCF: 106784472
NVI: 100115752
CSOL: 105360913
MDL: 103575039
TCA: 655451
DPA: 109539990
ATD: 109600158
NVL: 108558978
BMOR: 101741427
BMAN: 114241636
PMAC: 106712323
PRAP: 111002964
HAW: 110384151
TNL: 113492747
API: 103308067
DNX: 107172979
AGS: 114129907
RMD: 113554562
BTAB: 109033224
CLEC: 106663453
ZNE: 110833535
FCD: 110846318
PVM: 113822625
DPTE: 113791018
CSCU: 111622730
PTEP: 107456683
CEL: CELE_K09E4.2(algn-3)
CBR: CBG20997
TSP: Tsp_08712
PCAN: 112557649
CRG: 105346658
OBI: 106874294
LAK: 106174922
SHX: MS3_09308
NVE: 5518637
EPA: 110251455
ADF: 107332168
AMIL: 114965518
PDAM: 113686199
SPIS: 111328572
DGT: 114518083
HMG: 100214877
ATH: AT2G47760(ALG3)
ALY: 9318197
CRB: 17890265
BRP: 103866347
BOE: 106337396
RSZ: 108813443
THJ: 104802172
CPAP: 110821460
CIT: 102617688
TCC: 18613533
GRA: 105762674
DZI: 111314136
EGR: 104456792
VRA: 106758012
VAR: 108329708
VUN: 114186261
CCAJ: 109812263
CAM: 101509815
LJA: Lj1g3v4899050.1(Lj1g3v4899050.1)
ADU: 107492492
AIP: 107645621
FVE: 101310494
RCN: 112172534
PPER: 18767523
PMUM: 103333910
PAVI: 110761861
ZJU: 107426367
CSV: 101211394
CMO: 103492832
MCHA: 111020823
CMAX: 111488806
CMOS: 111456562
CPEP: 111807027
RCU: 8271753
JCU: 105642496
HBR: 110660934
MESC: 110615603
POP: 7457948
PEU: 105132014
VVI: 100253790
SLY: 101251511
SPEN: 107029293
SOT: 102598887
CANN: 107864015
NSY: 104225504
NTO: 104099176
INI: 109160269
SIND: 105165232
OEU: 111394355
HAN: 110895982
LSV: 111917946
CCAV: 112513534
DCR: 108224117
BVG: 104906606
SOE: 110797544
NNU: 104610985
PSOM: 113357561
OSA: 9266078
OBR: 102705966
BDI: 100822122
ATS: 109779517(LOC109779517)
SBI: 8056549
ZMA: 100276684
SITA: 101768406
PDA: 103712729
EGU: 105060271
MUS: 103981289
DCT: 110101639
PEQ: 110026944
AOF: 109841030
ATR: 18430288
SMO: SELMODRAFT_96090(GT58A1)
PPP: 112287567
APRO: F751_3769
SCE: YBL082C(ALG3)
ERC: Ecym_7147
KMX: KLMA_80379(ALG3)
NCS: NCAS_0E02510(NCAS0E02510)
NDI: NDAI_0E04080(NDAI0E04080)
TPF: TPHA_0K00760(TPHA0K00760)
TBL: TBLA_0D00510(TBLA0D00510)
TDL: TDEL_0C02670(TDEL0C02670)
KAF: KAFR_0L01850(KAFR0L01850)
PIC: PICST_58095(RHK1)
CAL: CAALFM_C604340WA(CaO19.1092)
NCR: NCU06552
NTE: NEUTE1DRAFT78420(NEUTE1DRAFT_78420)
MGR: MGG_08010
SSCK: SPSK_09197
MAW: MAC_01438
MAJ: MAA_07040
CMT: CCM_00021
BFU: BCIN_12g04720(Bcalg3)
MBE: MBM_00831
ANI: AN0104.2
ANG: ANI_1_1172164(An18g02360)
ABE: ARB_04378
TVE: TRV_03168
PNO: SNOG_16505(SNOG_16504)
PTE: PTT_10389
SPO: SPAC7D4.06c(alg3)
CNE: CNL04800
CNB: CNBI2040
TASA: A1Q1_00798
LBC: LACBIDRAFT_247511(ALG3)
SCM: SCHCODRAFT_51393(alg3)
ABP: AGABI1DRAFT118456(AGABI1DRAFT_118456)
ABV: AGABI2DRAFT200258(AGABI2DRAFT_200258)
MRT: MRET_3365
MSYM: MSY001_3019(ALG3)
DDI: DDB_G0268238(alg3)
DFA: DFA_10860(alg3)
FCY: FRACYDRAFT_180557(ALG3)
SPAR: SPRG_04773
EHX: EMIHUDRAFT_426313(ALG3-1) EMIHUDRAFT_521974(ALG3-2)
LMA: LMJF_36_2040(ALG3)
LIF: LINJ_36_2160(ALG3)
LPAN: LPMP_352120(ALG3)
 » show all
Reference
1  [PMID:11308030]
  Authors
Sharma CB, Knauer R, Lehle L
  Title
Biosynthesis of lipid-linked oligosaccharides in yeast: the ALG3 gene encodes the Dol-P-Man:Man5GlcNAc2-PP-Dol mannosyltransferase.
  Journal
Biol Chem 382:321-8 (2001)
DOI:10.1515/BC.2001.039
  Sequence
[sce:YBL082C]
Reference
2  [PMID:10660594]
  Authors
Cipollo JF, Trimble RB
  Title
The accumulation of Man(6)GlcNAc(2)-PP-dolichol in the Saccharomyces cerevisiae Deltaalg9 mutant reveals a regulatory role for the Alg3p alpha1,3-Man middle-arm  addition in downstream oligosaccharide-lipid and glycoprotein glycan processing.
  Journal
J Biol Chem 275:4267-77 (2000)
DOI:10.1074/jbc.275.6.4267
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.258
IUBMB Enzyme Nomenclature: 2.4.1.258
ExPASy - ENZYME nomenclature database: 2.4.1.258
BRENDA, the Enzyme Database: 2.4.1.258

KEGG   REACTION: R06258
Entry
R06258                      Reaction                               

Definition
Dolichyl phosphate D-mannose + G00006 <=> Dolichyl phosphate + G10595
Equation
Comment
ALG3
Enzyme
Pathway
rn00510  N-Glycan biosynthesis
rn00513  Various types of N-glycan biosynthesis
rn01100  Metabolic pathways
Module
M00055  N-glycan precursor biosynthesis
Orthology
K03845  alpha-1,3-mannosyltransferase [EC:2.4.1.258]
Other DBs
RHEA: 29530

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