KEGG ORTHOLOGY: K03870

ORTHOLOGY: K03870

Entry

K03870                      KO

Symbol

CUL2

Name

cullin 2

Pathway

map04066

HIF-1 signaling pathway

map04120

Ubiquitin mediated proteolysis

map05200

Pathways in cancer

map05211

Renal cell carcinoma

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K03870  CUL2; cullin 2
09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    K03870  CUL2; cullin 2
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03870  CUL2; cullin 2
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    K03870  CUL2; cullin 2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K03870  CUL2; cullin 2
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   Cul2 complex
    Cullin
     K03870  CUL2; cullin 2

Genes

HSA:	8453(CUL2)

PTR:	107976958(CUL2)

PPS:	100987655(CUL2)

GGO:	101152077(CUL2)

PON:	100174361(CUL2)

PPYG:

129006045(CUL2)

NLE:	100593391(CUL2)

HMH:	116461732(CUL2) 116465956

SSYN:

129480801(CUL2)

MCC:	698384(CUL2)

MCF:	102118914(CUL2)

MTHB:

126962982

MNI:	105495964(CUL2)

CSAB:

103238109(CUL2)

CATY:

105597003(CUL2)

PANU:

101012633(CUL2)

TGE:	112631654(CUL2)

MLEU:

105550257(CUL2)

RRO:	104666122(CUL2) 104675552

RBB:	108542604(CUL2)

TFN:	117082274(CUL2) 117082978

PTEH:

111546668(CUL2)

CANG:

105521839(CUL2)

CJC:	100395340(CUL2)

SBQ:	101051445(CUL2)

CIMI:

108309183(CUL2)

ANAN:

105712527(CUL2)

CSYR:

103260577(CUL2)

MMUR:

105871977(CUL2)

LCAT:

123626577(CUL2)

PCOQ:

105808528(CUL2)

OGA:	100953859(CUL2) 100966781

MMU:	71745(Cul2)

MCAL:

110284468(Cul2)

MPAH:

110333450(Cul2)

RNO:	361258(Cul2)

MCOC:

116086793(Cul2)

ANU:	117713834(Cul2)

MUN:	110558295(Cul2)

CGE:	100767582(Cul2)

MAUA:

101834411(Cul2)

PROB:

127237462(Cul2)

MORG:

121440750(Cul2)

MFOT:

126507870

AAMP:

119817525(Cul2)

NGI:	103734786(Cul2)

HGL:	101704513(Cul2)

CPOC:

100720235(Cul2)

CCAN:

109701020(Cul2)

DORD:

105980388(Cul2)

DSP:	122113139(Cul2)

PLOP:

125366712(Cul2)

NCAR:

124962213 124991019

MMMA:

107140410(Cul2)

OCU:

100343513

OPI:	101535291(CUL2)

TUP:	102499820(CUL2)

GVR:	103604482(CUL2)

CFA:	477952(CUL2)

CLUD:

112679005(CUL2)

VVP:	112921562(CUL2)

VLG:	121497204(CUL2)

NPO:	129499035(CUL2)

AML:	100475344(CUL2)

UMR:	103656516(CUL2)

UAH:	113244226(CUL2)

UAR:	123784871(CUL2)

ELK:

111155593

LLV:

125106920

MPUF:

101688744(CUL2)

MNP:	132020204(CUL2)

MLK:	131838313(CUL2)

NVS:	122892565(CUL2)

ORO:	101374279(CUL2) 101379527

EJU:	114222431(CUL2)

ZCA:	113920662 113922690(CUL2)

MLX:	118026626(CUL2)

NSU:	110576816(CUL2)

LWW:	102726203(CUL2)

FCA:	101094429(CUL2)

PYU:	121014613(CUL2)

PCOO:

112867260(CUL2)

PBG:	122473249(CUL2)

PVIV:

125170044(CUL2)

LRUF:

124501340

PTG:	102968019(CUL2)

PPAD:

109276290(CUL2)

PUC:

125920038

AJU:

106967342

HHV:	120247430(CUL2)

BTA:	535219(CUL2)

BOM:	102276684(CUL2)

BIU:	109567917(CUL2)

BBUB:

102398933(CUL2)

BBIS:

105002981(CUL2)

CHX:	102184164(CUL2)

OAS:	101122714(CUL2)

BTAX:

128058362(CUL2)

ODA:	120869243(CUL2)

CCAD:

122448292(CUL2)

MBEZ:

129557417(CUL2)

SSC:	100512186(CUL2)

CFR:	102503617(CUL2)

CBAI:

105078509(CUL2)

CDK:	105085988(CUL2)

VPC:	102531689(CUL2)

BACU:

103004461(CUL2)

BMUS:

118890624(CUL2)

LVE:	103074974(CUL2)

OOR:	101280322(CUL2)

DLE:	111178032(CUL2)

PCAD:

102987903(CUL2)

PSIU:

116749390(CUL2)

NASI:

112397947(CUL2)

ECB:	100054982(CUL2)

EPZ:	103559734(CUL2)

EAI:	106836625(CUL2)

MYB:	102254999(CUL2)

MYD:	102751888(CUL2) 102752770 102772271

MMYO:

118656714 118664716 118676439(CUL2)

MLF:	102441704(CUL2)

MDT:	132211229(CUL2) 132232963 132233806

PKL:	118728154(CUL2)

EFUS:

103299447(CUL2)

MNA:	107525068(CUL2)

DRO:	112317666(CUL2)

SHON:

118982722(CUL2)

AJM:	119038940(CUL2)

PDIC:

114491700(CUL2) 114506818

PHAS:

123806912(CUL2) 123814703

MMF:	118628306(CUL2)

PPAM:

129077769(CUL2)

HAI:	109388161(CUL2)

RFQ:	117022486(CUL2)

PALE:

102895656(CUL2)

PGIG:

120584130(CUL2)

PVP:	105303011(CUL2)

RAY:	107520742(CUL2)

MJV:	108392914(CUL2)

TOD:	119244614(CUL2) 119247036

SARA:

101554203(CUL2)

SETR:

126013380(CUL2)

LAV:	100662056(CUL2)

TMU:

101355736

ETF:	101654589(CUL2)

DNM:	101421380(CUL2)

MDO:	100018154(CUL2)

GAS:	123249627(CUL2)

SHR:	100934724(CUL2)

AFZ:

127564168

PCW:	110211238(CUL2)

TVP:	118850553(CUL2)

OAA:	100074001(CUL2)

GGA:	420467(CUL2)

PCOC:

116244384(CUL2)

MGP:

100550749

CJO:	107308915(CUL2)

TPAI:

128085456(CUL2)

LMUT:

125696455(CUL2)

NMEL:

110393688(CUL2)

APLA:

101791969(CUL2)

ACYG:

106045299(CUL2)

CATA:

118247369(CUL2)

AFUL:

116486007(CUL2)

TGU:	100221330(CUL2)

LSR:	110477301(CUL2)

SCAN:

103812744(CUL2)

PMOA:

120501388(CUL2)

OTC:	121338074(CUL2)

PRUF:

121364506(CUL2)

GFR:	102040500(CUL2)

FAB:	101814651(CUL2)

OMA:	130250133(CUL2)

PHI:	102110949(CUL2)

PMAJ:

107200262(CUL2)

CCAE:

111924081(CUL2)

CCW:	104686460(CUL2)

CBRC:

103620634(CUL2)

ETL:	114069724(CUL2)

ZAB:	102073913(CUL2)

ZLE:	135443610(CUL2)

ACHL:

103810860(CUL2)

SVG:	106862936(CUL2)

MMEA:

130576448(CUL2)

HRT:	120756958(CUL2)

SATI:

136358823(CUL2)

FPG:	101923525(CUL2)

FCH:	102057074(CUL2)

CCRI:

104166446(CUL2)

NNT:	104409519(CUL2)

SHAB:

115610321(CUL2)

ACUN:

113476615(CUL2)

TALA:

104369070(CUL2)

ACHC:

115339353(CUL2)

HALD:

104317502(CUL2)

HLE:	104842779(CUL2)

AGEN:

126037746

GCL:

127012523

CSTI:

104557655(CUL2)

LDI:	104342253(CUL2)

MNB:	103769241(CUL2)

DPUB:

104297051(CUL2)

AVIT:

104271743(CUL2)

BRHI:

104496171(CUL2)

EGZ:	104128525(CUL2)

NNI:	104022257(CUL2)

PCRI:

104032728(CUL2)

PCAO:

104044759(CUL2)

PADL:

103918250(CUL2)

AFOR:

103898372(CUL2)

FGA:	104075968(CUL2)

GSTE:

104250742(CUL2)

CLV:	102084287(CUL2)

MUI:	104538349(CUL2)

PGUU:

104461282(CUL2)

PLET:

104624745(CUL2)

EHS:	104517022(CUL2)

CMAC:

104477525(CUL2)

CUCA:

104066644(CUL2)

TEO:	104377800(CUL2)

BREG:

104635597(CUL2)

OHA:	104339017(CUL2)

ACAR:

104530023(CUL2)

CPEA:

104397063(CUL2)

CVF:	104295351(CUL2)

RTD:	128904871(CUL2)

AAM:	106490002(CUL2)

AROW:

112967399(CUL2)

NPD:	112955467(CUL2)

TGT:	104568812(CUL2)

DNE:	112984020(CUL2)

SCAM:

104150013(CUL2)

ASN:	102374109(CUL2)

AMJ:	102573468(CUL2)

CPOO:

109307202(CUL2)

GGN:	109291270(CUL2)

PSS:	102446788(CUL2)

CMY:	102937469(CUL2)

CCAY:

125631282(CUL2)

DCC:	119850944(CUL2)

CPIC:

101953216(CUL2)

TST:	117872070(CUL2)

CABI:

116833647(CUL2)

MRV:	120397377(CUL2)

ACS:	100560323(cul2)

ASAO:

132778952(CUL2)

PVT:	110082690(CUL2)

SUND:

121934107(CUL2)

PBI:	103055524(CUL2)

PMUR:

107284020(CUL2)

CTIG:

120306021(CUL2)

TSR:	106544007(CUL2) 106554996

PGUT:

117654978(CUL2)

APRI:

131198984(CUL2)

PTEX:

113442423(CUL2) 113451295

NSS:	113415017(CUL2) 113425918

VKO:	123020688(CUL2)

PMUA:

114607813(CUL2)

PRAF:

128398516(CUL2)

ZVI:	118091735(CUL2)

HCG:	128329115(CUL2)

GJA:	107105525(CUL2)

STOW:

125440972(CUL2)

EMC:	129337788(CUL2)

XLA:	108719839(cul2.S) 379729(cul2.L)

XTR:	100492608(cul2)

NPR:	108783701(CUL2)

RTEM:

120940058(CUL2)

BBUF:

121002758(CUL2)

BGAR:

122938003(CUL2)

MUO:	115467232(CUL2)

GSH:	117354284(CUL2)

DRE:	336088(cul2)

SRX:	107713926 107729921

SANH:

107653802(cul2) 107692764

SGH:	107552779 107593107(cul2)

CCAR:

109104254 109104257

CAUA:

113042225 113066322

CGIB:

127946048 128013390

PTET:

122329426(cul2)

LROH:

127155392(cul2)

OMC:	131533544(cul2)

PPRM:

120492339(cul2) 120492394

RKG:	130072108(cul2)

MAMB:

125257544(cul2)

CIDE:

127506132

CERY:

137014080(cul2)

MASI:

127431964 127434731

TROS:

130546774(cul2)

TDW:	130413534(cul2)

MANU:

129426152(cul2)

IPU:

108271969

IFU:	128614570(cul2)

PHYP:

113545478(cul2)

SMEO:

124384960(cul2)

TFD:	113644634(cul2)

TVC:	132845563(cul2)

TRN:	134309826(cul2)

AMEX:

103040496(cul2)

CMAO:

118816225(cul2)

EEE:	113579403(cul2)

CHAR:

105896311(cul2)

TRU:	101079145(cul2)

TFS:	130513431(cul2)

TNG:	GSTEN00016591G001

LCO:	104922456(cul2)

NCC:	104945543(cul2)

TBEN:

117483952(cul2)

CGOB:

115025751(cul2)

PGEO:

117465855(cul2)

GACU:

117550243(cul2)

EMAC:

134858094(cul2)

ELY:	117264260(cul2)

EFO:	125881924(cul2)

PLEP:

121960914(cul2) 121963933

SLUC:

116053646(cul2)

ECRA:

117937926(cul2)

ESP:	116672031(cul2)

PFLV:

114549501(cul2)

GAT:	120811431(cul2)

PPUG:

119198609(cul2)

AFB:	129110686(cul2)

CLUM:

117749585(cul2)

PSWI:

130206517(cul2)

MSAM:

119892974(cul2)

SCHU:

122866552(cul2)

CUD:	121527748(cul2)

ALAT:

119008727(cul2)

MZE:	101475619(cul2)

ONL:	100708908(cul2)

OAU:	116311285(cul2)

OLA:	101155234(cul2)

OML:	112151438(cul2)

CSAI:

133423438(cul2)

XMA:	102223207(cul2)

XCO:	114136817(cul2)

XHE:	116712000(cul2)

PRET:

103482243(cul2)

PFOR:

103143380(cul2)

PLAI:

106964701(cul2)

PMEI:

106930895(cul2)

GAF:	122824291(cul2)

PPRL:

129364860(cul2)

CVG:	107100777(cul2)

CTUL:

119787946(cul2)

GMU:	124858350(cul2)

NFU:	107396971(cul2)

KMR:	108245195(cul2)

ALIM:

106521109(cul2)

NWH:	119426529(cul2)

AOCE:

111563535(cul2)

MCEP:

124995874(cul2)

CSEM:

103377037(cul2)

POV:	109629875(cul2)

SSEN:

122779612(cul2)

HHIP:

117753993(cul2)

HSP:	118098565(cul2)

PPLT:

128425981(cul2)

SMAU:

118291202(cul2)

LCF:

108898318

SDU:	111228227(cul2)

SLAL:

111659848(cul2)

XGL:	120790136(cul2)

HCQ:	109512652(cul2)

SSCV:

125985895

SBIA:

133492459(cul2)

PEE:	133396655(cul2)

PTAO:

133470390(cul2)

BPEC:

110165521(cul2)

MALB:

109965162(cul2)

BSPL:

114854322(cul2)

SJO:	128382571(cul2)

SASA:

106578538(cul2)

STRU:

115153626 115195883

OTW:	112215582 112228057

OMY:	110490032 110536590

OGO:	123991148 124039856

ONE:	115105093 115130462

OKI:	109865747 109908713

OKE:	118361576 118376592

SALP:

111953437 111973082

SNH:	120027803 120051198

CCLU:

121549960 121570006

ELS:	105019434(cul2)

SFM:	108927550(cul2)

PKI:	111840757(cul2)

AANG:

118226424(cul2)

LOC:	102686389(cul2)

PSPA:

121311037 121314089

ARUT:

117395040 117400445(cul2)

PSEX:

120529616(cul2)

LCM:	102357434(CUL2)

CMK:	103178642(cul2)

RTP:	109923151(cul2)

CPLA:

122550086(cul2)

HOC:	132815815(cul2)

LERI:

129715354(cul2)

PMRN:

116948687(CUL2)

LRJ:	133349678(CUL2)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

ARUN:

AJC:

SKO:	100371067(CUL2)

DME:	Dmel_CG1512(Cul2)

DER:

6548789

DSI:	Dsimw501_GD24329(Dsim_GD24329)

DYA:	Dyak_GE12924

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI17442

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:	119687910 119688058

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105678860(Cul2)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:	108910652 108913555

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_203191B

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PGW:	126379141 126381499

CFEL:

113382947 113390824

CCRN:

123303125

API:	100161481 100164876

DNX:	107161869 107167531 107167610

AGS:

114126817

RMD:	113551651 113555815 113557945

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:	111048223 120356520

HVI:

124362921

MQU:	128989967 128990143

PHU:	Phum_PHUM422860

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_255909 DAPPUDRAFT_333213 DAPPUDRAFT_58155

DMK:

116928489

DPZ:	124310979 124345355 124348106

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136969147(Cul2)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_ZK520.4(cul-2)

CBR:	CBG_18282(Cbr-cul-2)

CRQ:	GCK72_010370

NAI:	NECAME_11538

BMY:	BM_BM10829(Bma-cul-2)

LOA:	LOAG_00325

HRO:	HELRODRAFT_190953

LGI:	LOTGIDRAFT_207667

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:	111114538 111114552

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_079740

SHX:	MS3_00005633(CUL2_1)

OVI:	T265_04792

EGL:

LLON:

NVE:

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:	114531241 114531917

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_22645

AQU:

100637741

EIN:	Eint_070800

EHE:	EHEL_070830

RIE:	OCT59_022714

SRE:	PTSG_08035

ACAN:

ACA1_292830

TVA:	TVAG_2v0644300

» show all

Reference

PMID:18187417

Authors

Mahrour N, Redwine WB, Florens L, Swanson SK, Martin-Brown S, Bradford WD, Staehling-Hampton K, Washburn MP, Conaway RC, Conaway JW

Title

Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases.

Journal

J Biol Chem 283:8005-13 (2008)
DOI:10.1074/jbc.M706987200

Sequence

[hsa:8453]

Reference

PMID:15601820

Authors

Kamura T, Maenaka K, Kotoshiba S, Matsumoto M, Kohda D, Conaway RC, Conaway JW, Nakayama KI.

Title

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.

Journal

Genes Dev 18:3055-65 (2004)
DOI:10.1101/gad.1252404

Sequence

[hsa:8453]

Reference

PMID:10587644

Authors

Feng H, Zhong W, Punkosdy G, Gu S, Zhou L, Seabolt EK, Kipreos ET

Title

CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans.

Journal

Nat Cell Biol 1:486-92 (1999)
DOI:10.1038/70272

Sequence

[cel:CELE_ZK520.4]

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (8)   
   KEGG PATHWAY (8)   
Gene (2814)   
   KEGG GENES (724)   
   KEGG MGENES (373)   
   RefGene (1707)   
   OC (10)   
Literature (3)   
   PubMed (3)   
All databases (2827)   

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