KEGG ORTHOLOGY: K03982

ORTHOLOGY: K03982

Entry

K03982                      KO

Symbol

SERPINE1, PAI1

Name

plasminogen activator inhibitor 1

Pathway

map04066

HIF-1 signaling pathway

map04115

p53 signaling pathway

map04218

Cellular senescence

map04371

Apelin signaling pathway

map04390

Hippo signaling pathway

map04610

Complement and coagulation cascades

map04933

AGE-RAGE signaling pathway in diabetic complications

map05142

Chagas disease

Disease

H01106

Plasminogen activator inhibitor type 1 deficiency

H01529

Avascular necrosis of femoral head

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
   04371 Apelin signaling pathway
    K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
   04066 HIF-1 signaling pathway
    K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
09140 Cellular Processes
  09143 Cell growth and death
   04115 p53 signaling pathway
    K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
   04218 Cellular senescence
    K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
09160 Human Diseases
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
   00536 Glycosaminoglycan binding proteins
    K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
Peptidases and inhibitors [BR:ko01002]
Peptidase inhibitors
  Family I4: serpin family
   K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Coagulation and fibrinolysis
   K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1

Other DBs

GO:

0004867

Genes

HSA:	5054(SERPINE1)

PTR:	472467(SERPINE1)

PPS:	100973457(SERPINE1)

GGO:	101149162(SERPINE1)

PON:	100435876(SERPINE1)

PPYG:

129041136(SERPINE1)

NLE:	100588010(SERPINE1)

HMH:	116810968(SERPINE1)

SSYN:

129489692(SERPINE1)

MCC:	713883(SERPINE1)

MCF:	102147003(SERPINE1)

MTHB:

126950371

MNI:	105492730(SERPINE1)

CSAB:

103246698(SERPINE1)

CATY:

105593415(SERPINE1)

PANU:

101018874(SERPINE1)

TGE:	112620079(SERPINE1)

MLEU:

105543353(SERPINE1)

RRO:	104681183(SERPINE1)

RBB:	108518939(SERPINE1)

TFN:	117072464(SERPINE1)

PTEH:

111527919(SERPINE1)

CANG:

105524685(SERPINE1)

CJC:	100385528(SERPINE1)

SBQ:	101045388(SERPINE1)

CIMI:

108307962(SERPINE1)

ANAN:

105714988(SERPINE1)

CSYR:

103271187(SERPINE1)

MMUR:

105868415(SERPINE1)

LCAT:

123631654(SERPINE1)

PCOQ:

105826028(SERPINE1)

OGA:	100961238(SERPINE1)

MMU:	18787(Serpine1)

MPAH:

110313068(Serpine1)

RNO:	24617(Serpine1)

MCOC:

116070958(Serpine1)

ANU:	117698004(Serpine1)

MUN:	110566254(Serpine1)

CGE:	100759702(Serpine1)

MAUA:

101829368(Serpine1)

PROB:

127236977(Serpine1)

PLEU:

114710323(Serpine1)

MORG:

121446504(Serpine1)

MFOT:

126491913

AAMP:

119825044(Serpine1)

NGI:	103733497(Serpine1)

HGL:	101703903(Serpine1)

CPOC:

100725387(Serpine1)

CCAN:

109692813(Serpine1)

DORD:

105997335(Serpine1)

DSP:	122113847(Serpine1)

PLOP:

125367828(Serpine1)

NCAR:

124970506

MMMA:

107147076(Serpine1)

OCU:

100009588

OPI:	101527810(SERPINE1)

TUP:	102478468(SERPINE1)

GVR:	103604901(SERPINE1)

CFA:	403476(SERPINE1)

CLUD:

112646212(SERPINE1)

VVP:	112935788(SERPINE1)

VLG:	121487837(SERPINE1)

NPO:	129519469(SERPINE1)

AML:	100483472(SERPINE1)

UMR:	103670125(SERPINE1)

UAH:	113267839(SERPINE1)

UAR:	123777298(SERPINE1)

ELK:

111145849

LLV:

125090991

MPUF:

101685128(SERPINE1)

MNP:	132026574(SERPINE1)

MLK:	131820123(SERPINE1)

NVS:	122895984(SERPINE1)

ORO:	101382421(SERPINE1)

EJU:	114214452(SERPINE1)

ZCA:	113933082(SERPINE1)

MLX:	117999438(SERPINE1)

NSU:	110582402(SERPINE1)

LWW:	102736969(SERPINE1)

FCA:	100127105(SERPINE1)

PYU:	121017655(SERPINE1)

PCOO:

112860099(SERPINE1)

PBG:	122471312(SERPINE1)

PVIV:

125154539(SERPINE1)

LRUF:

124519326

PTG:	102972312(SERPINE1)

PPAD:

109250526(SERPINE1)

PUC:

125928213

AJU:

106988114

HHV:	120239343(SERPINE1)

BTA:	281375(SERPINE1)

BOM:	102275884(SERPINE1)

BIU:	109578652(SERPINE1)

BBUB:

102391372(SERPINE1)

BBIS:

104983114(SERPINE1)

CHX:	102169375(SERPINE1)

OAS:	100381267(SERPINE1)

BTAX:

128069199(SERPINE1)

ODA:	120879013(SERPINE1)

CCAD:

122433325(SERPINE1)

MBEZ:

129545661(SERPINE1)

SSC:	396945(SERPINE1)

CFR:	102505188(SERPINE1)

CBAI:

105067242(SERPINE1)

CDK:	105092393(SERPINE1)

VPC:	102530260(SERPINE1)

BACU:

103019421(SERPINE1)

BMUS:

118880700(SERPINE1)

LVE:	103091622(SERPINE1)

OOR:	101273613(SERPINE1)

DLE:	111182313(SERPINE1)

PCAD:

102996444(SERPINE1)

PSIU:

116739522(SERPINE1)

NASI:

112399965(SERPINE1)

ECB:	100033931(SERPINE1)

EPZ:	103541183(SERPINE1)

EAI:	106839300(SERPINE1)

MYB:	102262847(SERPINE1)

MYD:	102771956(SERPINE1)

MMYO:

118656393(SERPINE1)

MLF:	102419788(SERPINE1)

MDT:	132233243(SERPINE1)

PKL:	118703386(SERPINE1)

EFUS:

103286004(SERPINE1)

MNA:	107526505(SERPINE1)

DRO:	112314968(SERPINE1)

SHON:

118992847(SERPINE1)

AJM:	119044724(SERPINE1)

PDIC:

114494615(SERPINE1)

PHAS:

123806329(SERPINE1)

MMF:	118642598(SERPINE1)

PPAM:

129083449(SERPINE1)

HAI:	109385046(SERPINE1)

RFQ:	117025318(SERPINE1)

PALE:

102880028(SERPINE1)

PGIG:

120591668(SERPINE1)

PVP:	105299725(SERPINE1)

RAY:	107511771(SERPINE1)

MJV:	108395779(SERPINE1)

TOD:	119241565(SERPINE1)

SARA:

101548448(SERPINE1)

SETR:

126029597(SERPINE1)

LAV:	100660994(SERPINE1)

TMU:

101348466

ETF:	101651774(SERPINE1)

DNM:	101444311(SERPINE1)

MDO:	100017921(SERPINE1)

GAS:	123245045(SERPINE1)

SHR:	100922915(SERPINE1)

AFZ:

127560959

PCW:	110194266(SERPINE1)

TVP:	118855922(SERPINE1)

OAA:	100090599(SERPINE1)

PRUF:

121349664

OMA:

130263313

ZLE:

135460684

ACHC:

115338409(SERPINE1)

AGEN:

126034679

ASN:

102369661

AMJ:	102563594(SERPINE1)

PSS:	102443480(SERPINE1)

CCAY:

125628741(SERPINE1)

DCC:	119849330(SERPINE1)

CPIC:

101946709 101950595(SERPINE1)

CABI:

116817068(SERPINE1)

MRV:	120381365(SERPINE1)

ACS:	100558317(serpine1)

ASAO:

132777459(SERPINE1)

PVT:	110077425(SERPINE1)

SUND:

121934387(SERPINE1)

PBI:	103062655(SERPINE1)

PMUR:

107285052(SERPINE1)

CTIG:

120299749(SERPINE1)

TSR:	106551758(SERPINE1)

PGUT:

117673437(SERPINE1)

APRI:

131198480(SERPINE1)

PTEX:

113453551 113453553

NSS:	113428226(SERPINE1)

VKO:	123021756(SERPINE1)

PMUA:

114582468(SERPINE1)

PRAF:

128400711(SERPINE1)

ZVI:	118094767(SERPINE1)

HCG:	128329886(SERPINE1)

GJA:	107113525(SERPINE1)

STOW:

125445189(SERPINE1)

EMC:	129340303(SERPINE1)

XLA:	100049768(serpine1.S) 779433(serpine1.L)

XTR:	100127732(serpine1)

NPR:	108795423(SERPINE1)

RTEM:

120933479(SERPINE1)

BBUF:

120986514(SERPINE1)

BGAR:

122929282(SERPINE1)

MUO:	115458099(SERPINE1)

GSH:	117350679(SERPINE1)

DRE:	100136840(serpine1)

SRX:	107750568(serpine1) 107754656

SANH:

107666277 107668101

SGH:	107563319 107593715

CCAR:

109092992 109092994

CAUA:

113052059 113105786

CGIB:

127962721 128017068

PTET:

122349747(serpine1)

LROH:

127168792(serpine1)

OMC:	131544085(serpine1)

PPRM:

120483800(serpine1)

RKG:	130102636(serpine1)

MAMB:

125264604(serpine1)

CIDE:

127515273

CERY:

137030259(serpine1)

MASI:

127412875 127446043

TROS:

130556162(serpine1)

TDW:	130420913(serpine1)

MANU:

129441189(serpine1)

IPU:	108267921(serpine1)

IFU:	128610038(serpine1)

PHYP:

113539927(serpine1)

SMEO:

124387411(serpine1)

TFD:	113657498(serpine1)

TVC:	132848603(serpine1)

TRN:	134312315(serpine1)

AMEX:

103042062(serpine1)

CMAO:

118826188(serpine1)

EEE:	113580806(serpine1)

CHAR:

105895519(serpine1)

TRU:	101069978(serpine1)

TFS:	130523039(serpine1)

TNG:	GSTEN00003787G001

LCO:	104938952(serpine1)

NCC:	104941435(serpine1)

TBEN:

117490074(serpine1)

CGOB:

115023708(serpine1)

PGEO:

117463325(serpine1)

GACU:

117542738(serpine1)

EMAC:

134876084(serpine1)

ELY:	117272732(serpine1)

EFO:	125884093(serpine1)

PLEP:

121962315(serpine1)

SLUC:

116035962(serpine1)

ECRA:

117934800(serpine1)

ESP:	116707196(serpine1)

PFLV:

114545689(serpine1)

GAT:	120823006(serpine1)

PPUG:

119223734(serpine1)

AFB:	129093470(serpine1)

CLUM:

117747966(serpine1)

PSWI:

130211831(serpine1)

MSAM:

119913367(serpine1)

SCHU:

122870527(serpine1)

CUD:	121504932(serpine1)

ALAT:

119027844(serpine1)

MZE:	101481046(serpine1)

ONL:	100703589(serpine1)

OAU:	116324065(serpine1)

OLA:	100529196(serpine1)

OML:	112155692(serpine1)

CSAI:

133420170(serpine1)

XMA:	102226229(serpine1)

XCO:	114158035(serpine1)

XHE:	116733414(serpine1)

PRET:

103480133

PFOR:

103148861

PLAI:

106956049(serpine1)

PMEI:

106924430(serpine1)

GAF:	122820458(serpine1)

PPRL:

129378242(serpine1)

CVG:	107100683(serpine1)

CTUL:

119785450(serpine1)

GMU:	124880223(serpine1)

NFU:

107374548

KMR:	108242259(serpine1)

ALIM:

106526972(serpine1)

NWH:	119414284(serpine1)

AOCE:

111567630(serpine1)

CSEM:

103385566

POV:	109637625(serpine1)

SSEN:

122765963(serpine1)

HHIP:

117779322(serpine1)

HSP:	118102255(serpine1)

PPLT:

128430476(serpine1)

SMAU:

118304429(serpine1)

LCF:

108879720

SDU:	111226956(serpine1)

SLAL:

111654376(serpine1)

XGL:	120787480(serpine1)

HCQ:	109520372(serpine1)

SSCV:

125992616

SBIA:

133494427(serpine1)

PEE:	133397604(serpine1)

PTAO:

133472384(serpine1)

BPEC:

110170785

BSPL:

114849348(serpine1)

SJO:	128383890(serpine1)

SASA:

106577897 106608947

STRU:

115194599 115198564

OTW:	112214536 112259747

OMY:	110500366(serpine1) 110531459

OGO:	124007850 124014143

ONE:	115133324 115137888

OKI:	109880450 109896857

OKE:	118368985 118392192

SALP:

112070854 112071513

SNH:	120030394 120049289

CCLU:

121554620 121572739

ELS:	105031309(serpine1)

SFM:	108922853(serpine1)

PKI:	111852922 111854452

AANG:

118222321(serpine1)

LOC:	102696166(serpine1)

PSPA:

121305739(serpine1) 121306552

ARUT:

117404447 117962359

PSEX:

120525250(serpine1)

LCM:	102360184(SERPINE1)

CMK:	103190657(serpine1)

CPLA:

122544328(serpine1)

HOC:	132835162(serpine1)

LERI:

LBD:

PMEO:

BBES:

Reference

PMID:18445685

Authors

Vial D, McKeown-Longo PJ

Title

PAI1 stimulates assembly of the fibronectin matrix in osteosarcoma cells through crosstalk between the alphavbeta5 and alpha5beta1 integrins.

Journal

J Cell Sci 121:1661-70 (2008)
DOI:10.1242/jcs.020149

Reference

PMID:2430793

Authors

Pannekoek H, Veerman H, Lambers H, Diergaarde P, Verweij CL, van Zonneveld AJ, van Mourik JA

Title

Endothelial plasminogen activator inhibitor (PAI): a new member of the Serpin gene family.

Journal

EMBO J 5:2539-44 (1986)
DOI:10.1002/j.1460-2075.1986.tb04532.x

Sequence

[hsa:5054]

All links

Ontology (5)   
   KEGG BRITE (4)   
   GO (1)   
Pathway (16)   
   KEGG PATHWAY (16)   
Disease (2)   
   KEGG DISEASE (2)   
Drug (3)   
   KEGG DRUG (3)   
Gene (430)   
   KEGG GENES (344)   
   KEGG MGENES (34)   
   RefGene (49)   
   OC (3)   
Literature (2)   
   PubMed (2)   
All databases (458)   

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