KEGG ORTHOLOGY: K03990

ORTHOLOGY: K03990

Entry

K03990                      KO

Symbol

Name

complement component 3

Pathway

map04080

Neuroactive ligand-receptor interaction

map04145

Phagosome

map04610

Complement and coagulation cascades

map04613

Neutrophil extracellular trap formation

map04936

Alcoholic liver disease

map05131

Shigellosis

map05133

Pertussis

map05134

Legionellosis

map05140

Leishmaniasis

map05142

Chagas disease

map05150

Staphylococcus aureus infection

map05152

Tuberculosis

map05167

Kaposi sarcoma-associated herpesvirus infection

map05168

Herpes simplex virus 1 infection

map05171

Coronavirus disease - COVID-19

map05203

Viral carcinogenesis

map05322

Systemic lupus erythematosus

Disease

H00102

Classic complement pathway component defects

H00821

Age-related macular degeneration

H01434

Atypical hemolytic uremic syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K03990  C3; complement component 3
09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K03990  C3; complement component 3
09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K03990  C3; complement component 3
   04613 Neutrophil extracellular trap formation
    K03990  C3; complement component 3
09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K03990  C3; complement component 3
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K03990  C3; complement component 3
   05168 Herpes simplex virus 1 infection
    K03990  C3; complement component 3
   05167 Kaposi sarcoma-associated herpesvirus infection
    K03990  C3; complement component 3
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K03990  C3; complement component 3
   05133 Pertussis
    K03990  C3; complement component 3
   05134 Legionellosis
    K03990  C3; complement component 3
   05150 Staphylococcus aureus infection
    K03990  C3; complement component 3
   05152 Tuberculosis
    K03990  C3; complement component 3
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K03990  C3; complement component 3
   05142 Chagas disease
    K03990  C3; complement component 3
  09163 Immune disease
   05322 Systemic lupus erythematosus
    K03990  C3; complement component 3
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K03990  C3; complement component 3
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K03990  C3; complement component 3
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K03990  C3; complement component 3
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K03990  C3; complement component 3
Peptidases and inhibitors [BR:ko01002]
Peptidase inhibitors
  Family I39: alpha2M family
   K03990  C3; complement component 3
Membrane trafficking [BR:ko04131]
Endocytosis
  Phagocytosis
   Opsonins
    K03990  C3; complement component 3
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of other cancer cells
   K03990  C3; complement component 3

Genes

HSA:

718(C3)

PTR:	455644(C3)

PPS:	100982432(C3)

GGO:	101139062(C3)

PON:	100446798(C3)

PPYG:

129019382(C3)

NLE:	100598784(C3)

HMH:	116478338(C3)

SSYN:

129461217(C3)

MCC:	703613(C3)

MCF:	102131458(C3)

MTHB:

126942463

MNI:	105487051(C3)

CSAB:

103234342(C3)

CATY:

105591872(C3)

PANU:

101006748(C3)

TGE:	112612406(C3)

MLEU:

105530124(C3)

RRO:	104665361(C3)

RBB:	108534593(C3)

TFN:	117075829(C3)

PTEH:

111522637(C3)

CANG:

105512957(C3)

CJC:	100400501(C3)

SBQ:	101044671(C3)

CIMI:

108304218(C3)

ANAN:

105706013(C3)

CSYR:

103263117(C3)

MMUR:

105869696(C3)

LCAT:

123635930(C3)

PCOQ:

105811847(C3)

OGA:	100946120(C3)

MMU:

12266(C3)

MCAL:

110312494(C3)

MPAH:

110335652(C3)

RNO:

24232(C3)

MCOC:

116075112(C3)

ANU:	117705843(C3)

MUN:	110545607(C3)

CGE:	100763958(C3)

MAUA:

101842900(C3)

PROB:

127216803(C3)

PLEU:

114686534(C3)

MORG:

121459351 121459724

MFOT:

126490398

AAMP:

119806181(C3)

NGI:	103737182(C3)

HGL:	101726247(C3)

CPOC:

100135462(C3)

CCAN:

109694300(C3) 109698715

DORD:

105990428(C3)

DSP:	122122722(C3)

PLOP:

125348555(C3)

NCAR:

124968300

OCU:	100009121(C3)

OPI:	101524590(C3)

TUP:	102487294(C3)

GVR:	103599528(C3)

CFA:	476728(C3)

CLUD:

112666383(C3)

VVP:	112911820(C3)

VLG:	121494843(C3)

NPO:	129521931(C3)

AML:	100472549(C3)

UMR:	103681871(C3)

UAH:	113242886(C3)

UAR:	123779001(C3)

ELK:

111161841

LLV:

125086252

MPUF:

101670415(C3)

MNP:	132010864(C3)

MLK:	131823371(C3)

NVS:	122909817(C3)

ORO:	101385252(C3)

EJU:	114226149(C3)

ZCA:	113916865(C3)

MLX:	118004908(C3)

NSU:	110593993(C3)

LWW:	102735244(C3)

FCA:	101088220 101088468 111557813

PBG:	122486797 122486798 122486799

PVIV:

125156563 125156577 125159006

LRUF:

124522820 124522854 124522856 124522857 124522858 124523587 124523589 124523590 124524010

PTG:	102951325 102968028(C3) 102968326

PPAD:

109261021(C3) 109261022

PUC:

125916839

AJU:	106975430 128314961 128314963

HHV:	120223290 120223291 120226861

BTA:	280677(C3)

BOM:	102270836(C3)

BIU:	109561686(C3)

BBUB:

102407588(C3)

BBIS:

104979920(C3)

CHX:	100860826(C3)

OAS:	101108131(C3) 114114921

BTAX:

128050332 128050333

ODA:	120860432 120860434

CCAD:

122440309(C3)

MBEZ:

129558674(C3)

SSC:	397072(C3)

CFR:	102512172(C3)

CBAI:

105078264(C3)

CDK:	105104550(C3)

VPC:	102545824(C3)

BACU:

103011779(C3)

BMUS:

118892101(C3)

LVE:	103083690(C3)

OOR:	101281425(C3)

DLE:	111166019(C3)

PCAD:

102979432(C3)

PSIU:

116751208(C3)

NASI:

112400183(C3)

ECB:	100060505 100060539

EPZ:	103540378(C3)

EAI:	106827903 106832730

MYD:

102754026

MMYO:

118658864(C3)

MLF:	102419585 102419899 102422416 102422871 102442843

MDT:	132235107 132235108 132235109

PKL:	118731250 118731258(C3)

EFUS:

103304493 103304972 114229623 114229624

MNA:	107525753(C3)

DRO:	112312430(C3)

SHON:

118984567(C3)

AJM:	119056019 119063704(C3)

PDIC:

114502979(C3)

PHAS:

123813746(C3)

MMF:	118615878(C3)

PPAM:

129061553(C3)

RFQ:	117037783(C3)

PALE:

102882350(C3)

PGIG:

120615453(C3)

PVP:	105301109(C3)

RAY:	107511212(C3)

MJV:	108401780(C3)

TOD:	119240637(C3)

SARA:

101550718(C3) 101550987

SETR:

126031197(C3)

LAV:	100657489(C3)

TMU:

101350977

ETF:	101661246(C3)

DNM:	101411049 101421283

MDO:	100020034(C3)

SHR:	100934148(C3)

AFZ:

127544864

PCW:	110197414(C3)

TVP:	118841480 118846086(C3)

OAA:	100074341 100074389

GGA:	396370(C3)

PCOC:

116239209(C3)

MGP:	100551026(C3)

TPAI:

128081278

LMUT:

125687481(C3)

NMEL:

110391242(C3)

APLA:

101793615(C3)

ACYG:

106049436(C3)

CATA:

118261166(C3)

AFUL:

116500102(C3)

TGU:	100222821(C3)

PMOA:

120505096(C3)

OTC:	121339175(C3)

PRUF:

121360561(C3)

GFR:

102043273

FAB:

101805832

OMA:	130263027(C3)

PHI:	102102912(C3)

CBRC:

103619027

ZAB:	102074317(C3)

ZLE:	135460576 135460910

SVG:	106864353(C3)

HRT:

120747836

SATI:

136374694(C3)

FPG:	101923177(C3)

FCH:	102047045(C3)

CCRI:

104161736

NNT:	104413102(C3)

SHAB:

115602826(C3)

ACUN:

113490564(C3)

TALA:

104361896(C3)

ACHC:

115348358(C3)

HALD:

104316150

HLE:	104832615(C3)

AGEN:

126043161

GCL:

127028730

CSTI:

104559174(C3)

LDI:	104342118(C3)

BRHI:

104496002(C3)

EGZ:	104129973(C3)

NNI:	104014965(C3)

PCRI:

104026733(C3)

PCAO:

104047284(C3)

PADL:

103916897(C3)

AFOR:

103894331(C3)

FGA:	104072294(C3)

GSTE:

104264677(C3)

CLV:	102087426(C3)

MUI:	104545385(C3)

PGUU:

104467925

PLET:

104622761(C3)

EHS:

104510764

CMAC:

104483480(C3)

CUCA:

104063122(C3)

TEO:	104383484(C3)

BREG:

104631707(C3)

OHA:	104332205(C3)

ACAR:

104523480(C3)

CVF:	104291645(C3)

RTD:	128901505(C3)

AROW:

112960884(C3)

NPD:	112956616(C3)

TGT:	104568028(C3)

DNE:	112994401(C3)

SCAM:

104141177(C3)

ASN:	102382385(C3) 102382810

AMJ:	102561850(C3) 102566534

PSS:	102452901(C3)

CMY:	102933485 102939244 102941775

CCAY:

125627517 125627527 125627805

DCC:	119845779 119845818 119845819 119846023

CPIC:

101931940 101950459 101952632 101953192(C3)

TST:	117889179 117889180(C3) 117889181

CABI:

116826049 116826473 116826481 116826585 116830888

MRV:	120391020 120391057 120391359 120391361 120391362 120394936

ACS:	100555124(c3) 100560431 100566793 100566988

ASAO:

132765496 132765510(C3) 132768035 132768036 132768040

PVT:

110090193

SUND:

121920513 121921766(C3)

PBI:	103048059(C3)

PMUR:

107283590 107287994

CTIG:

120305432(C3) 120310464

PGUT:

117656646 117675612 132708866

APRI:

131192086 131192129

VKO:	123029972 123030054 123030055 123030064(C3)

PMUA:

114587731

PRAF:

128405172(C3)

ZVI:	118097504 118097624

HCG:	128346561 128347948

GJA:

107125723

STOW:

125427953(C3)

EMC:	129346041(C3)

XLA:	108703407 108703501 108703502 108711728 108711733 398666(c3.L) 495206

XTR:	100170611 100216255(c3) 100491968 100492134 100492966 100497762 100497914 108646250

NPR:	108791483 108794623(C3)

RTEM:

120933436 120933437 120933438 120933439 120933443

BBUF:

120986494 120986495 120986497 120986498 120986500 120986502 120988554 120988562 120988569

BGAR:

122922745 122925554 122925555 122925556 122927154(C3) 122927155 122927156 122927157 122927158 122927159

MUO:	115465968(C3)

GSH:	117350068(C3)

DRE:	30491(c3a.2) 321046(c3a.1) 494039(c3a.6) 565074(c3a.3)

SRX:	107749247 107749251 107749254

SANH:

107703739 107703740 107703742

SGH:	107569282 107572269 107594231 107594234

CCAR:

109074247

CAUA:

113049555 113049641 113049778 113049880 113049957 113097363

CGIB:

127948620 128017873 128017899 128017931 128017967

PTET:

122343817(c3a.6) 122344622

LROH:

127161208 127161801 127162055 127165087(c3a.6) 127171776

OMC:	131526119 131530188 131545854 131545870 131545887

PPRM:

120459623 120459639

RKG:	130105836 130105875(c3a.6)

MAMB:

125271343(c3a.6) 125271344 125271347 125271348 125271349 125271352 125271388 125271856

CIDE:

127512252 127512476 127512656

CERY:

137031473 137031475 137031478 137031480 137031494 137031495 137031496 137031522 137032410 137033105

MASI:

127443530 127443595 127443608 127444706

TROS:

130553063 130553165 130553167 130553261

TDW:	130435230 130435236 130435244 130435269 130435281 130435303 130435310 130435318 130435990

MANU:

129443864 129443865 129443866 129443872(c3a.6) 129443875

IPU:	108258708 124627631

IFU:	128601906 128602411 128602412

PHYP:

113537390

SMEO:

124378330 124378332 124378333 124378334 124378346

TFD:	113636342 113636343 113636345 113636373 113636374 125140403

TVC:	132839479 132839480 132839481 132839483

TRN:	134329448 134329449 134329450

AMEX:

103045627

CMAO:

118803197 118803202 118803209 118803210

EEE:

113591926

CHAR:

105891048 105891049 105891050 105891051 105894698 105900851 105906714

TRU:	101063400 101066599(c3) 101067488

TFS:	130527596 130527734 130527831

TNG:	GSTEN00026332G001

LCO:

104939795

TBEN:

117469431 117469487 117474610 117478279 117484060 117484068

CGOB:

115008178(c3)

PGEO:

117463419 117463489 117463503 117463707 117463708

GACU:

117536248 117561640

EMAC:

134864524

ELY:	117254689 117254690 117254691

EFO:	125886023 125886024 125886025

PLEP:

121941800 121941801 121941806

SLUC:

116042788 116042789 116042790 116042791 116042833 116042834 116058019 116059158 116062589 116062590 116064053 116065087

ESP:	116697857 116700184 116700215

PFLV:

114547234 114556706 114556727 114556732 114561480 114561496 114565280 114565288 114565298 114566131 114566147 114571643

GAT:	120824684 120824685 120825658

PPUG:

119218642

AFB:	129095872 129116349 129116350

CLUM:

117745115

PSWI:

130189682

MSAM:

119887213 119887216 119887225 119899478 119899479

SCHU:

122873336 122873341 122873342

CUD:	121507905 121507906 121508442

ALAT:

119019512 119021043 119021685 119028201

MZE:	101465376 101480237

ONL:	100691651 100692186 100700974

OAU:	116310586 116310625 116310626 116310627 116317080

OLA:	100125801(c3-1) 100125802(c3-2) 101168584 110015899

OML:	112137453 112137454 112137455 112137456

CSAI:

133426015 133426047 133443690 133443725 133443746 133443784

XMA:

102235663

XCO:

114144597

XHE:	116719574 116719577(c3) 116719586

PRET:

103475608(c3) 103478388

PFOR:

103133105 103154171 103154176 103154177 103156320

PLAI:

106937002 106937003 106937005 106955498(c3)

PMEI:

106911935 106922023 106922060 106922061 106922062 106928488

GAF:	122829687 122829688 122829689 122829690

PPRL:

CVG:

CTUL:

GMU:

NFU:	107391903(c3)

KMR:

108241457

ALIM:

106528528(c3)

NWH:	119422319 119423085 119423086

AOCE:

111584065(c3)

MCEP:

125003431 125003432 125003434

CSEM:

103383921

POV:

109627599

SSEN:

122760818 122760819 122760825 122770798 122771053 122771054

HHIP:

117757720 117768518

HSP:	118101979 118103836 118125095

PPLT:

128431064 128431074 128431082 128431104

SMAU:

118312169

LCF:

108885437

SDU:

111229209

SLAL:

111665554(c3)

XGL:	120799887 120799888

HCQ:	109527282(c3)

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

MALB:

109952399(c3)

BSPL:

114851133 114851145 114851158 114851165 114852270 114853922

SJO:	128371262 128371275 128371287 128371468 128385113

SASA:

106595495 106597357 106604987

STRU:

115176828 115176838 115176856 115177199 115178882 115208541

OTW:	112246076 112246089 112246615

OMY:	100135918 100136952(c3-3) 110489008 110489018 110489027 110517348 110530587 118939581

OGO:	123997597 123997598 124003045 124005876 124009958 124016498

ONE:	115103919 115105510 115141221 115141222 115142627

OKI:	109865657 109874801 109889906 109902151 109902154 109909959

OKE:	118365025 118367354 118389144 118401883 127914282 127914283

SALP:

111982296 112070548

SNH:	120031250 120032617 120048323 120048324 120048325 120056079 120065323

CCLU:

121542153 121586872

ELS:	105009354 105009355 105019308

SFM:

108919697

PKI:	111841378(c3)

AANG:

118220714 118220715 118220716 118220717

LOC:	102687466 102688099 102688304(c3)

PSPA:

121304496 121304554

ARUT:

117398833 117409788 117420346 117966830

PSEX:

120519369 120541093 120541094

LCM:	102353531(C3)

CMK:

103191243

RTP:	109916785 109918583

CPLA:

122552261 122552262

HOC:	132835853 132835854

LERI:

129714485

PMRN:

116942274 116942275

LRJ:	133349569 133349575 133349576

CIN:	445694(c3-1)

SCLV:

120326265 120333779 120344170 120345661 120345662

RMP:

VDE:

VJA:

DFR:

CVS:

BEQ:	BEWA_024150

» show all

Reference

PMID:2579379

Authors

de Bruijn MH, Fey GH

Title

Human complement component C3: cDNA coding sequence and derived primary structure.

Journal

Proc Natl Acad Sci U S A 82:708-12 (1985)
DOI:10.1073/pnas.82.3.708

Sequence

[hsa:718]

Reference

PMID:10432298

Authors

Murray I, Kohl J, Cianflone K

Title

Acylation-stimulating protein (ASP): structure-function determinants of cell surface binding and triacylglycerol synthetic activity.

Journal

Biochem J 342 ( Pt 1):41-8 (1999)
DOI:10.1042/bj3420041

Sequence

[hsa:718]

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (34)   
   KEGG PATHWAY (34)   
Disease (3)   
   KEGG DISEASE (3)   
Drug (1)   
   KEGG DRUG (1)   
Gene (1097)   
   KEGG GENES (780)   
   KEGG MGENES (197)   
   RefGene (106)   
   OC (14)   
Literature (2)   
   PubMed (2)   
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