KEGG   ORTHOLOGY: K03992
Entry
K03992                      KO                                     

Name
MASP1
Definition
mannan-binding lectin serine protease 1 [EC:3.4.21.-]
Pathway
ko04610  Complement and coagulation cascades
ko05150  Staphylococcus aureus infection
ko05171  Coronavirus disease - COVID-19
Disease
H01887  3MC syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K03992  MASP1; mannan-binding lectin serine protease 1
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K03992  MASP1; mannan-binding lectin serine protease 1
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K03992  MASP1; mannan-binding lectin serine protease 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K03992  MASP1; mannan-binding lectin serine protease 1
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.-  
     K03992  MASP1; mannan-binding lectin serine protease 1
Peptidases and inhibitors [BR:ko01002]
 Serine peptidases
  Family S1: chymotrypsin family
   K03992  MASP1; mannan-binding lectin serine protease 1
Genes
HSA: 5648(MASP1)
PTR: 460925(MASP1)
PPS: 100970830(MASP1)
GGO: 101144543(MASP1)
PON: 100439814(MASP1)
NLE: 100601109(MASP1)
MCC: 708206(MASP1)
MCF: 101866962(MASP1)
CSAB: 103241880(MASP1)
RRO: 104653539(MASP1)
RBB: 108530465(MASP1)
CJC: 100407253(MASP1)
SBQ: 101033147(MASP1)
MMU: 17174(Masp1)
MCAL: 110311194(Masp1)
MPAH: 110329505(Masp1)
RNO: 64023(Masp1)
MUN: 110548132(Masp1)
CGE: 100774526(Masp1)
NGI: 103750158(Masp1)
HGL: 101716867(Masp1)
CCAN: 109691384(Masp1)
OCU: 100009493(MASP1)
TUP: 102495635(MASP1)
CFA: 488121(MASP1)
VVP: 112926302(MASP1)
AML: 100480813(MASP1)
UMR: 103676043(MASP1)
UAH: 113253785(MASP1)
ORO: 101378116(MASP1)
ELK: 111147948
FCA: 101097166(MASP1)
PTG: 102955238(MASP1)
PPAD: 109275285(MASP1)
AJU: 106968007(MASP1)
BTA: 522347(MASP1)
BOM: 102281916(MASP1)
BIU: 109556918(MASP1)
BBUB: 102397764(MASP1)
CHX: 102171378(MASP1)
OAS: 101111065(MASP1)
SSC: 100152125(MASP1)
CFR: 102513366(MASP1)
CDK: 105085838(MASP1)
BACU: 103011616(MASP1)
LVE: 103086594(MASP1)
OOR: 101285880(MASP1)
DLE: 111172796(MASP1)
PCAD: 102991396(MASP1)
ECB: 100068261(MASP1)
EPZ: 103560383(MASP1)
EAI: 106832546(MASP1)
MYB: 102243096(MASP1)
MYD: 102755101(MASP1)
MNA: 107527305(MASP1)
HAI: 109371149(MASP1)
DRO: 112305221(MASP1)
PALE: 102887394(MASP1)
RAY: 107505896(MASP1)
MJV: 108401267(MASP1)
LAV: 100664949(MASP1)
TMU: 101351430
MDO: 100012016(MASP1)
SHR: 100928712(MASP1)
PCW: 110210181
OAA: 100082252(MASP1)
GGA: 407088(MASP1)
MGP: 100551064(MASP1)
CJO: 107318290(MASP1)
NMEL: 110398922(MASP1)
APLA: 101804768(MASP1)
ACYG: 106044834(MASP1)
TGU: 100231782(MASP1)
LSR: 110473898(MASP1)
SCAN: 103815377(MASP1)
GFR: 102035329(MASP1)
FAB: 101806498(MASP1)
PHI: 102100134(MASP1)
PMAJ: 107209043(MASP1)
CCAE: 111933612(MASP1)
CCW: 104688121(MASP1)
ETL: 114057583(MASP1)
FPG: 101918512(MASP1)
FCH: 102049370(MASP1)
CLV: 102098561(MASP1)
EGZ: 104123371(MASP1)
NNI: 104015662(MASP1)
ACUN: 113483356(MASP1)
PADL: 103916576(MASP1)
AAM: 106498133(MASP1)
ASN: 102384513(MASP1)
AMJ: 102571302(MASP1)
PSS: 102444258
CMY: 102939563(MASP1)
CPIC: 101942804(MASP1)
ACS: 100561598(masp1)
PBI: 103054041(MASP1)
PMUR: 107298710(MASP1)
PMUA: 114598179(MASP1)
GJA: 107113844(MASP1)
XLA: 398413(masp1.S) 398414(masp1/3a)
XTR: 100038300(masp1)
NPR: 108791178(MASP1)
DRE: 100002060(masp1)
SRX: 107721148 107739768
SANH: 107683390 107704738
SGH: 107582221 107586740
CCAR: 109084544 109105323
IPU: 108278363(masp1)
PHYP: 113544654(masp1)
AMEX: 103022902(masp1)
EEE: 113588982(masp1) 113592077
TRU: 101068213
TNG: GSTEN00021129G001 GSTEN00021132G001
LCO: 104934180(masp1)
MZE: 101472632(masp1)
ONL: 100694109
XMA: 102236429(masp1)
XCO: 114161716(masp1)
PRET: 103475256(masp1)
NFU: 107379927
KMR: 108250973(masp1)
ALIM: 106534438(masp1)
AOCE: 111573564(masp1)
CSEM: 103378121(masp1)
POV: 109645354(masp1)
LCF: 108902922(masp1)
SDU: 111216830(masp1)
SLAL: 111646697(masp1)
HCQ: 109526211(masp1)
BPEC: 110172161(masp1)
MALB: 109972737(masp1)
SASA: 106612353(masp1)
OTW: 112241937 112247114
SALP: 111960634(masp1)
ELS: 105008657(masp1)
SFM: 108922148(masp1)
PKI: 111842724(masp1)
LCM: 102365424(MASP1)
CMK: 103190722(masp1)
BFO: 118430323
CIN: 100181065 100183415 100185892 100186241
APLC: 110986473 110989287 110989288
ATD: 109606980
PTEP: 107439355
NVE: 5501844 5505914 5516231
EPA: 110254010
ADF: 107334181 107334686 107354865
AMIL: 114946797 114947799 114967993
PDAM: 113676140 113684181
SPIS: 111332800 111332818 111338418
DGT: 114525919
HMG: 100198529
 » show all
Reference
  Authors
Moller-Kristensen M, Thiel S, Sjoholm A, Matsushita M, Jensenius JC
  Title
Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway.
  Journal
Int Immunol 19:141-9 (2007)
DOI:10.1093/intimm/dxl131
  Sequence
[hsa:5648]
Reference
PMID:8240317
  Authors
Takada F, Takayama Y, Hatsuse H, Kawakami M
  Title
A new member of the C1s family of complement proteins found in a bactericidal factor, Ra-reactive factor, in human serum.
  Journal
Biochem Biophys Res Commun 196:1003-9 (1993)
DOI:10.1006/bbrc.1993.2349
  Sequence
[hsa:5648]

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (1)   
   KEGG DISEASE (1)   
Gene (651)   
   KEGG GENES (175)   
   KEGG MGENES (97)   
   RefGene (368)   
   OC (11)   
Literature (2)   
   PubMed (2)   
All databases (663)   

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KEGG   ORTHOLOGY: K03993
Entry
K03993                      KO                                     

Name
MASP2
Definition
mannan-binding lectin serine protease 2 [EC:3.4.21.104]
Pathway
ko04610  Complement and coagulation cascades
ko05150  Staphylococcus aureus infection
ko05171  Coronavirus disease - COVID-19
Disease
H00105  Mannose-binding lectin pathway component defects
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K03993  MASP2; mannan-binding lectin serine protease 2
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K03993  MASP2; mannan-binding lectin serine protease 2
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K03993  MASP2; mannan-binding lectin serine protease 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K03993  MASP2; mannan-binding lectin serine protease 2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.104  mannan-binding lectin-associated serine protease-2
     K03993  MASP2; mannan-binding lectin serine protease 2
Peptidases and inhibitors [BR:ko01002]
 Serine peptidases
  Family S1: chymotrypsin family
   K03993  MASP2; mannan-binding lectin serine protease 2
Genes
HSA: 10747(MASP2)
PTR: 107974877(MASP2)
PPS: 100981899(MASP2)
GGO: 101126677(MASP2)
PON: 100458242(MASP2)
NLE: 100593253(MASP2)
MCC: 722714(MASP2)
MCF: 102131322(MASP2)
CSAB: 103225618(MASP2)
RRO: 104654364(MASP2)
RBB: 108539381(MASP2)
CJC: 100408774(MASP2)
SBQ: 101047723(MASP2)
MMU: 17175(Masp2)
MCAL: 110292278(Masp2)
MPAH: 110323473(Masp2)
RNO: 64459(Masp2)
MUN: 110548141(Masp2)
CGE: 100756295 100770654
NGI: 103733193(Masp2)
HGL: 101696699(Masp2) 101706103
CCAN: 109689658(Masp2)
TUP: 102488905(MASP2)
CFA: 487447(MASP2)
VVP: 112929686(MASP2)
AML: 100466924(MASP2)
UMR: 103666866(MASP2)
UAH: 113270516(MASP2)
ORO: 101362776(MASP2)
ELK: 111154710 111154837
FCA: 101099568(MASP2)
PPAD: 109274100(MASP2)
AJU: 106984902(MASP2)
BTA: 505819(MASP2)
BOM: 102280596(MASP2)
BIU: 109570390(MASP2)
BBUB: 102414667(MASP2)
CHX: 102169785(MASP2)
SSC: 100302537(MASP2)
CFR: 102513488(MASP2)
CDK: 105107020(MASP2)
BACU: 103005678(MASP2)
LVE: 103083615(MASP2)
OOR: 101283337(MASP2)
DLE: 111187114(MASP2)
PCAD: 102973281(MASP2)
ECB: 100056770(MASP2)
EPZ: 103552243(MASP2)
EAI: 106836680(MASP2)
MYB: 102255311
MYD: 102764933(MASP2)
MNA: 107540993(MASP2)
HAI: 109381284(MASP2)
DRO: 112299103(MASP2)
PALE: 102885750(MASP2)
RAY: 107513106(MASP2)
MJV: 108395496(MASP2) 108401888
LAV: 100662293(MASP2)
TMU: 101342871
MDO: 100018957(MASP2)
SHR: 100932261(MASP2)
OAA: 100079601(MASP2)
GGA: 407089(MASP2)
MGP: 100547191(MASP2)
CJO: 107323403(MASP2)
NMEL: 110408613(MASP2)
APLA: 101801331(MASP2)
ACYG: 106040226(MASP2)
TGU: 100232734(MASP2)
GFR: 102032737(MASP2)
PHI: 102110924(MASP2)
EGZ: 104133133(MASP2)
PADL: 103917979(MASP2)
AAM: 106482473(MASP2)
ASN: 102370755(MASP2)
PSS: 102453425(MASP2)
CMY: 102929438(MASP2)
CPIC: 101950973(MASP2)
PVT: 110073231(MASP2)
PBI: 103053568(MASP2)
PMUR: 107295524(MASP2) 107301108
TSR: 106548091(MASP2)
PMUA: 114602450(MASP2)
GJA: 107124364(MASP2)
XLA: 108696362(masp2.L) 373654(masp2.S)
XTR: 496446(masp2)
NPR: 108789090
DRE: 560277(masp2)
SRX: 107708846
SANH: 107681988(masp2)
SGH: 107571531
CCAR: 109048441
IPU: 108268494 108268542 108276220(masp2)
PHYP: 113530393(masp2)
AMEX: 103023364(masp2)
EEE: 113581290(masp2)
TRU: 101078225(masp2)
NCC: 104954130(masp2)
MZE: 101487177(masp2)
ONL: 100703975(masp2)
OLA: 101160657(masp2)
XMA: 102226518(masp2) 102236233
XCO: 114141728(masp2) 114142162
PRET: 103467229(masp2)
CVG: 107086886
NFU: 107379963 107390742(masp2)
KMR: 108236764(masp2)
ALIM: 106536928
AOCE: 111566407(masp2)
CSEM: 103384955(masp2)
POV: 109630666(masp2)
LCF: 108876586(masp2)
SDU: 111219203(masp2)
SLAL: 111670573(masp2)
HCQ: 109526567(masp2)
BPEC: 110164865(masp2)
MALB: 109968959(masp2)
SASA: 106572058(masp2) 106597909 106605730
OTW: 112216045 112232616
SALP: 111966480(masp2)
ELS: 105022975(masp2)
SFM: 108923279(masp2)
PKI: 111834328(masp2)
LCM: 102360645(MASP2)
PTEP: 107450699
LGI: LOTGIDRAFT_164015
 » show all
Reference
  Authors
Matsushita M, Thiel S, Jensenius JC, Terai I, Fujita T.
  Title
Proteolytic activities of two types of mannose-binding lectin-associated serine protease.
  Journal
J Immunol 165:2637-42 (2000)
DOI:10.4049/jimmunol.165.5.2637
  Sequence
[hsa:10747]
Reference
PMID:9087411
  Authors
Thiel S, Vorup-Jensen T, Stover CM, Schwaeble W, Laursen SB, Poulsen K, Willis AC, Eggleton P, Hansen S, Holmskov U, Reid KB, Jensenius JC.
  Title
A second serine protease associated with mannan-binding lectin that activates complement.
  Journal
Nature 386:506-10 (1997)
DOI:10.1038/386506a0
  Sequence
[hsa:10747]

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (234)   
   KEGG GENES (140)   
   KEGG MGENES (10)   
   RefGene (78)   
   OC (6)   
Literature (2)   
   PubMed (2)   
All databases (248)   

Download RDF
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