KEGG   ORTHOLOGY: K03992
Entry
K03992                      KO                                     

Name
MASP1
Definition
mannan-binding lectin serine protease 1 [EC:3.4.21.-]
Pathway
ko04610  Complement and coagulation cascades
ko05150  Staphylococcus aureus infection
ko05171  Coronavirus disease - COVID-19
Disease
H01887  3MC syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K03992  MASP1; mannan-binding lectin serine protease 1
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K03992  MASP1; mannan-binding lectin serine protease 1
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K03992  MASP1; mannan-binding lectin serine protease 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K03992  MASP1; mannan-binding lectin serine protease 1
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.-  
     K03992  MASP1; mannan-binding lectin serine protease 1
Peptidases and inhibitors [BR:ko01002]
 Serine peptidases
  Family S1: chymotrypsin family
   K03992  MASP1; mannan-binding lectin serine protease 1
Genes
HSA: 5648(MASP1)
PTR: 460925(MASP1)
PPS: 100970830(MASP1)
GGO: 101144543(MASP1)
PON: 100439814(MASP1)
NLE: 100601109(MASP1)
MCC: 708206(MASP1)
MCF: 101866962(MASP1)
CSAB: 103241880(MASP1)
RRO: 104653539(MASP1)
RBB: 108530465(MASP1)
CJC: 100407253(MASP1)
SBQ: 101033147(MASP1)
MMU: 17174(Masp1)
MCAL: 110311194(Masp1)
MPAH: 110329505(Masp1)
RNO: 64023(Masp1)
MUN: 110548132(Masp1)
CGE: 100774526(Masp1)
NGI: 103750158(Masp1)
HGL: 101716867(Masp1)
CCAN: 109691384(Masp1)
OCU: 100009493(MASP1)
TUP: 102495635(MASP1)
CFA: 488121(MASP1)
VVP: 112926302(MASP1)
AML: 100480813(MASP1)
UMR: 103676043(MASP1)
UAH: 113253785(MASP1)
ORO: 101378116(MASP1)
ELK: 111147948
FCA: 101097166(MASP1)
PTG: 102955238(MASP1)
PPAD: 109275285(MASP1)
AJU: 106968007(MASP1)
BTA: 522347(MASP1)
BOM: 102281916(MASP1)
BIU: 109556918(MASP1)
BBUB: 102397764(MASP1)
CHX: 102171378(MASP1)
OAS: 101111065(MASP1)
SSC: 100152125(MASP1)
CFR: 102513366(MASP1)
CDK: 105085838(MASP1)
BACU: 103011616(MASP1)
LVE: 103086594(MASP1)
OOR: 101285880(MASP1)
DLE: 111172796(MASP1)
PCAD: 102991396(MASP1)
ECB: 100068261(MASP1)
EPZ: 103560383(MASP1)
EAI: 106832546(MASP1)
MYB: 102243096(MASP1)
MYD: 102755101(MASP1)
MNA: 107527305(MASP1)
HAI: 109371149(MASP1)
DRO: 112305221(MASP1)
PALE: 102887394(MASP1)
RAY: 107505896(MASP1)
MJV: 108401267(MASP1)
LAV: 100664949(MASP1)
TMU: 101351430
MDO: 100012016(MASP1)
SHR: 100928712(MASP1)
PCW: 110210181
OAA: 100082252(MASP1)
GGA: 407088(MASP1)
MGP: 100551064(MASP1)
CJO: 107318290(MASP1)
NMEL: 110398922(MASP1)
APLA: 101804768(MASP1)
ACYG: 106044834(MASP1)
TGU: 100231782(MASP1)
LSR: 110473898(MASP1)
SCAN: 103815377(MASP1)
GFR: 102035329(MASP1)
FAB: 101806498(MASP1)
PHI: 102100134(MASP1)
PMAJ: 107209043(MASP1)
CCAE: 111933612(MASP1)
CCW: 104688121(MASP1)
ETL: 114057583(MASP1)
FPG: 101918512(MASP1)
FCH: 102049370(MASP1)
CLV: 102098561(MASP1)
EGZ: 104123371(MASP1)
NNI: 104015662(MASP1)
ACUN: 113483356(MASP1)
PADL: 103916576(MASP1)
AAM: 106498133(MASP1)
ASN: 102384513(MASP1)
AMJ: 102571302(MASP1)
PSS: 102444258
CMY: 102939563(MASP1)
CPIC: 101942804(MASP1)
ACS: 100561598(masp1)
PBI: 103054041(MASP1)
PMUR: 107298710(MASP1)
PMUA: 114598179(MASP1)
GJA: 107113844(MASP1)
XLA: 398413(masp1.S) 398414(masp1/3a)
XTR: 100038300(masp1)
NPR: 108791178(MASP1)
DRE: 100002060(masp1)
IPU: 108278363(masp1)
PHYP: 113544654(masp1)
AMEX: 103022902(masp1)
EEE: 113588982(masp1) 113592077
TRU: 101068213
LCO: 104934180(masp1)
MZE: 101472632(masp1)
ONL: 100694109
XMA: 102236429(masp1)
XCO: 114161716(masp1)
PRET: 103475256(masp1)
NFU: 107379927
KMR: 108250973(masp1)
ALIM: 106534438(masp1)
AOCE: 111573564(masp1)
CSEM: 103378121(masp1)
POV: 109645354(masp1)
LCF: 108902922(masp1)
SDU: 111216830(masp1)
SLAL: 111646697(masp1)
HCQ: 109526211(masp1)
BPEC: 110172161(masp1)
MALB: 109972737(masp1)
SASA: 106612353(masp1)
SALP: 111960634(masp1)
ELS: 105008657(masp1)
SFM: 108922148(masp1)
PKI: 111842724(masp1)
LCM: 102365424(MASP1)
CMK: 103190722(masp1)
BFO: 118430323
ATD: 109606980
PTEP: 107439355
EPA: 110254010
DGT: 114525919
HMG: 100198529
 » show all
Reference
  Authors
Moller-Kristensen M, Thiel S, Sjoholm A, Matsushita M, Jensenius JC
  Title
Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway.
  Journal
Int Immunol 19:141-9 (2007)
DOI:10.1093/intimm/dxl131
  Sequence
[hsa:5648]
Reference
PMID:8240317
  Authors
Takada F, Takayama Y, Hatsuse H, Kawakami M
  Title
A new member of the C1s family of complement proteins found in a bactericidal factor, Ra-reactive factor, in human serum.
  Journal
Biochem Biophys Res Commun 196:1003-9 (1993)
DOI:10.1006/bbrc.1993.2349
  Sequence
[hsa:5648]

KEGG   ORTHOLOGY: K03993
Entry
K03993                      KO                                     

Name
MASP2
Definition
mannan-binding lectin serine protease 2 [EC:3.4.21.104]
Pathway
ko04610  Complement and coagulation cascades
ko05150  Staphylococcus aureus infection
ko05171  Coronavirus disease - COVID-19
Disease
H00105  Mannose-binding lectin pathway component defects
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K03993  MASP2; mannan-binding lectin serine protease 2
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K03993  MASP2; mannan-binding lectin serine protease 2
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K03993  MASP2; mannan-binding lectin serine protease 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K03993  MASP2; mannan-binding lectin serine protease 2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.104  mannan-binding lectin-associated serine protease-2
     K03993  MASP2; mannan-binding lectin serine protease 2
Peptidases and inhibitors [BR:ko01002]
 Serine peptidases
  Family S1: chymotrypsin family
   K03993  MASP2; mannan-binding lectin serine protease 2
Genes
HSA: 10747(MASP2)
PTR: 107974877(MASP2)
PPS: 100981899(MASP2)
GGO: 101126677(MASP2)
PON: 100458242(MASP2)
NLE: 100593253(MASP2)
MCC: 722714(MASP2)
MCF: 102131322(MASP2)
CSAB: 103225618(MASP2)
RRO: 104654364(MASP2)
RBB: 108539381(MASP2)
CJC: 100408774(MASP2)
SBQ: 101047723(MASP2)
MMU: 17175(Masp2)
MCAL: 110292278(Masp2)
MPAH: 110323473(Masp2)
RNO: 64459(Masp2)
MUN: 110548141(Masp2)
NGI: 103733193(Masp2)
HGL: 101696699(Masp2) 101706103
CCAN: 109689658(Masp2)
TUP: 102488905(MASP2)
CFA: 487447(MASP2)
VVP: 112929686(MASP2)
AML: 100466924(MASP2)
UMR: 103666866(MASP2)
UAH: 113270516(MASP2)
ORO: 101362776(MASP2)
FCA: 101099568(MASP2)
PPAD: 109274100(MASP2)
AJU: 106984902(MASP2)
BTA: 505819(MASP2)
BOM: 102280596(MASP2)
BIU: 109570390(MASP2)
BBUB: 102414667(MASP2)
CHX: 102169785(MASP2)
SSC: 100302537(MASP2)
CFR: 102513488(MASP2)
CDK: 105107020(MASP2)
BACU: 103005678(MASP2)
LVE: 103083615(MASP2)
OOR: 101283337(MASP2)
DLE: 111187114(MASP2)
PCAD: 102973281(MASP2)
ECB: 100056770(MASP2)
EPZ: 103552243(MASP2)
EAI: 106836680(MASP2)
MYB: 102255311
MYD: 102764933(MASP2)
MNA: 107540993(MASP2)
HAI: 109381284(MASP2)
DRO: 112299103(MASP2)
PALE: 102885750(MASP2)
RAY: 107513106(MASP2)
MJV: 108395496(MASP2) 108401888
LAV: 100662293(MASP2)
TMU: 101342871
MDO: 100018957(MASP2)
SHR: 100932261(MASP2)
OAA: 100079601(MASP2)
GGA: 407089(MASP2)
MGP: 100547191(MASP2)
CJO: 107323403(MASP2)
NMEL: 110408613(MASP2)
APLA: 101801331(MASP2)
ACYG: 106040226(MASP2)
TGU: 100232734(MASP2)
GFR: 102032737(MASP2)
PHI: 102110924(MASP2)
EGZ: 104133133(MASP2)
PADL: 103917979(MASP2)
AAM: 106482473(MASP2)
ASN: 102370755(MASP2)
PSS: 102453425(MASP2)
CMY: 102929438(MASP2)
CPIC: 101950973(MASP2)
PVT: 110073231(MASP2)
PBI: 103053568(MASP2)
PMUR: 107295524(MASP2) 107301108
TSR: 106548091(MASP2)
PMUA: 114602450(MASP2)
GJA: 107124364(MASP2)
XLA: 108696362(masp2.L) 373654(masp2.S)
XTR: 496446(masp2)
NPR: 108789090
DRE: 560277(masp2)
SRX: 107708846
SANH: 107681988(masp2)
SGH: 107571531
CCAR: 109048441
PHYP: 113530393(masp2)
AMEX: 103023364(masp2)
EEE: 113581290(masp2)
TRU: 101078225(masp2)
NCC: 104954130(masp2)
MZE: 101487177(masp2)
ONL: 100703975(masp2)
OLA: 101160657(masp2)
XMA: 102226518(masp2) 102236233
XCO: 114141728(masp2) 114142162
PRET: 103467229(masp2)
CVG: 107086886
NFU: 107379963 107390742(masp2)
KMR: 108236764(masp2)
ALIM: 106536928
AOCE: 111566407(masp2)
CSEM: 103384955(masp2)
POV: 109630666(masp2)
LCF: 108876586(masp2)
SDU: 111219203(masp2)
SLAL: 111670573(masp2)
HCQ: 109526567(masp2)
BPEC: 110164865(masp2)
MALB: 109968959(masp2)
SALP: 111966480(masp2)
ELS: 105022975(masp2)
SFM: 108923279(masp2)
PKI: 111834328(masp2)
LCM: 102360645(MASP2)
PTEP: 107450699
 » show all
Reference
  Authors
Matsushita M, Thiel S, Jensenius JC, Terai I, Fujita T.
  Title
Proteolytic activities of two types of mannose-binding lectin-associated serine protease.
  Journal
J Immunol 165:2637-42 (2000)
DOI:10.4049/jimmunol.165.5.2637
  Sequence
[hsa:10747]
Reference
PMID:9087411
  Authors
Thiel S, Vorup-Jensen T, Stover CM, Schwaeble W, Laursen SB, Poulsen K, Willis AC, Eggleton P, Hansen S, Holmskov U, Reid KB, Jensenius JC.
  Title
A second serine protease associated with mannan-binding lectin that activates complement.
  Journal
Nature 386:506-10 (1997)
DOI:10.1038/386506a0
  Sequence
[hsa:10747]

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