KEGG   ORTHOLOGY: K04100
Entry
K04100                      KO                                     

Name
ligA
Definition
protocatechuate 4,5-dioxygenase, alpha chain [EC:1.13.11.8]
Pathway
ko00362  Benzoate degradation
ko00624  Polycyclic aromatic hydrocarbon degradation
ko00627  Aminobenzoate degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K04100  ligA; protocatechuate 4,5-dioxygenase, alpha chain
   00627 Aminobenzoate degradation
    K04100  ligA; protocatechuate 4,5-dioxygenase, alpha chain
   00624 Polycyclic aromatic hydrocarbon degradation
    K04100  ligA; protocatechuate 4,5-dioxygenase, alpha chain
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.8  protocatechuate 4,5-dioxygenase
     K04100  ligA; protocatechuate 4,5-dioxygenase, alpha chain
Other DBs
RN: R01632 R03550 R04280 R09272 R09565
GO: 0018579
Genes
VNA: PN96_18545
VEJ: VEJY3_18111
VFL: AL536_10310
EMO: DM558_04790(ligA)
PAT: Patl_3886
PCAR: PC2016_2101
AAW: AVL56_08865
ALR: DS731_01515
CSA: Csal_0325
MMW: Mmwyl1_0508 Mmwyl1_3921 Mmwyl1_3939
RFO: REIFOR_00545(ligA)
NAQ: D0T90_09310(ligA)
NBL: GJV52_09130(ligA)
BPH: Bphy_3205
BPX: BUPH_06639(ligA)
HYF: DTO96_100892(ligA_1)
AFQ: AFA_05520(ligA)
AAQU: D3M96_07060(ligA)
ACRA: BSY15_1237
CTES: O987_16265
COF: FOZ74_08485(ligA)
RTA: Rta_24770
LIM: L103DPR2_01497(ligA_1) L103DPR2_01514(ligA_2)
LIH: L63ED372_01144(ligA_1)
HYR: BSY239_1243(ligA) BSY239_2223(ligA)
HYC: E5678_08760(ligA)
HPSE: HPF_08080(ligA1) HPF_08185(ligA2)
DIH: G7047_27835(ligA)
SNN: EWH46_19140(ligA)
AZO: azo2523(ligA1) azo2538(ligA2)
TCL: Tchl_1061
BRA: BRADO2341(ligA) BRADO2379
BBT: BBta_2701(ligA) BBta_2733
BRO: BRAD285_4959(ligA) BRAD285_4996(ligA)
RPA: RPA1006 RPA4701(ligA)
RPD: RPD_0983
RPE: RPE_0750
MALG: MALG_02286
HBA: Hbal_2593
NOV: TQ38_025025(ligA) TQ38_028410(ligA)
SMAZ: LH19_17695
SPHI: TS85_18515
SSAN: NX02_17505
SPHC: CVN68_17245(ligA)
SPHR: BSY17_3447(ligA)
SHYD: CJD35_16820(ligA) CJD35_19575(ligA)
SYA: A6768_17480(ligA)
SFLA: SPHFLASMR4Y_02987(ligA)
SPHY: CHN51_00895(ligA)
BLAS: BSY18_3523(ligA)
RDI: CMV14_06885(ligA)
SPHS: ETR14_07930(ligA)
AAY: WYH_01046(ligA_2) WYH_01908(ligA_3) WYH_03215(ligA_4)
ADO: A6F68_01080(ligA_1)
POT: E2E27_18120(ligA)
MAG: amb0257
MAGX: XM1_1094
MAGN: WV31_13630
MAGQ: MGMAQ_2662(ligA) MGMAQ_2669(ligA)
NCB: C0V82_22495(ligA)
AMIN: AUMI_19390
AUW: AURUGA1_00419(ligA_1)
BSD: BLASA_2598(ligA)
MMAR: MODMU_2844(ligA)
PDX: Psed_2465
PAUT: Pdca_48150
AG: AAA17727(ligA)
 » show all
Reference
PMID:2185230
  Authors
Noda Y, Nishikawa S, Shiozuka K, Kadokura H, Nakajima H, Yoda K, Katayama Y, Morohoshi N, Haraguchi T, Yamasaki M
  Title
Molecular cloning of the protocatechuate 4,5-dioxygenase genes of Pseudomonas paucimobilis.
  Journal
J Bacteriol 172:2704-9 (1990)
DOI:10.1128/JB.172.5.2704-2709.1990
  Sequence

KEGG   ORTHOLOGY: K04101
Entry
K04101                      KO                                     

Name
ligB
Definition
protocatechuate 4,5-dioxygenase, beta chain [EC:1.13.11.8]
Pathway
ko00362  Benzoate degradation
ko00624  Polycyclic aromatic hydrocarbon degradation
ko00627  Aminobenzoate degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K04101  ligB; protocatechuate 4,5-dioxygenase, beta chain
   00627 Aminobenzoate degradation
    K04101  ligB; protocatechuate 4,5-dioxygenase, beta chain
   00624 Polycyclic aromatic hydrocarbon degradation
    K04101  ligB; protocatechuate 4,5-dioxygenase, beta chain
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.8  protocatechuate 4,5-dioxygenase
     K04101  ligB; protocatechuate 4,5-dioxygenase, beta chain
Other DBs
RN: R01632 R03550 R04280 R09272 R09565
GO: 0018579
Genes
VNA: PN96_18550
VEJ: VEJY3_18116
VFL: AL536_10315
PVR: PverR02_14345
AVN: Avin_42210
AVL: AvCA_42210
AVD: AvCA6_42210
EMO: DM558_04785
PAT: Patl_3885
PCAR: PC2016_2100
CSA: Csal_0324
RFO: REIFOR_00546(ligB)
KKI: KKKWG1_0313(ligB)
BPH: Bphy_3204
PPUL: RO07_25060
HYF: DTO96_100893(ligB)
AFQ: AFA_05515
ACRA: BSY15_1238
CTES: O987_16260
RTA: Rta_24760
LIM: L103DPR2_01498(ligB_1) L103DPR2_01515(ligB_2)
LIH: L63ED372_01145(ligB)
HPSE: HPF_08085(ligB1) HPF_08190(ligB2)
DAR: Daro_3248
AZO: azo2522(ligB1) azo2537(ligB2)
TCL: Tchl_1062
BRA: BRADO2342(ligB) BRADO2380(mhpB)
BBT: BBta_2702(ligB) BBta_2734(mhpB)
BRO: BRAD285_4958(ligB) BRAD285_4995(ligB)
RPA: RPA1007(mhpB) RPA4702(ligB)
RPD: RPD_0982
RPE: RPE_0751
MMED: Mame_04593(ligB)
MALG: MALG_02287
HBA: Hbal_2592
SMAZ: LH19_17690
SPHI: TS85_18520
SSAN: NX02_17500
SPHB: EP837_03494(ligB)
SPHR: BSY17_3446(ligB)
BLAS: BSY18_3524(ligB)
AAY: WYH_01045(ligB_1) WYH_01909(ligB_2) WYH_03214(ligB_3)
ADO: A6F68_01079(ligB)
MAG: amb0258
MAGX: XM1_1095(ligB)
MAGN: WV31_13635
ABS: AZOBR_p310188(mhpB)
TMO: TMO_b0115(mhpB)
MAGQ: MGMAQ_2661(ligB) MGMAQ_2670(ligB)
AMIN: AUMI_19380
AUW: AURUGA1_00420(ligB)
NML: Namu_0046
BSD: BLASA_2599(ligB)
MMAR: MODMU_2843(ligB) MODMU_3384
PSEA: WY02_25080
PAUT: Pdca_48140(pcaH_2)
ACTN: L083_0820
AFS: AFR_03865
PFLA: Pflav_029940(pcaH_1)
AFO: Afer_2021
AG: AAA17728(ligB)
 » show all
Reference
PMID:2185230
  Authors
Noda Y, Nishikawa S, Shiozuka K, Kadokura H, Nakajima H, Yoda K, Katayama Y, Morohoshi N, Haraguchi T, Yamasaki M
  Title
Molecular cloning of the protocatechuate 4,5-dioxygenase genes of Pseudomonas paucimobilis.
  Journal
J Bacteriol 172:2704-9 (1990)
DOI:10.1128/JB.172.5.2704-2709.1990
  Sequence

KEGG   ENZYME: 1.13.11.8
Entry
EC 1.13.11.8                Enzyme                                 

Name
protocatechuate 4,5-dioxygenase;
protocatechuate 4,5-oxygenase;
protocatechuic 4,5-dioxygenase;
protocatechuic 4,5-oxygenase;
protocatechuate:oxygen 4,5-oxidoreductase (decyclizing);
protocatechuate:oxygen 4,5-oxidoreductase (ring-opening)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
3,4-dihydroxybenzoate:oxygen 4,5-oxidoreductase (ring-opening)
Reaction(IUBMB)
3,4-dihydroxybenzoate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde [RN:R01632]
Reaction(KEGG)
R01632;
(other) R03550 R04280 R09272 R09565
Substrate
3,4-dihydroxybenzoate [CPD:C00230];
O2 [CPD:C00007]
Product
4-carboxy-2-hydroxymuconate semialdehyde [CPD:C04484]
Comment
Requires Fe2+.
History
EC 1.13.11.8 created 1965 as EC 1.13.1.8, transferred 1972 to EC 1.13.11.8
Pathway
ec00362  Benzoate degradation
ec00624  Polycyclic aromatic hydrocarbon degradation
ec00627  Aminobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K04100  protocatechuate 4,5-dioxygenase, alpha chain
K04101  protocatechuate 4,5-dioxygenase, beta chain
Genes
VNA: PN96_18545 PN96_18550
VEJ: VEJY3_18111 VEJY3_18116
VFL: AL536_10310 AL536_10315
PVR: PverR02_14345
AVN: Avin_42210
AVL: AvCA_42210
AVD: AvCA6_42210
EMO: DM558_04785 DM558_04790(ligA)
PAT: Patl_3885 Patl_3886
PCAR: PC2016_2100 PC2016_2101
RFO: REIFOR_00545(ligA) REIFOR_00546(ligB)
KKI: KKKWG1_0313(ligB)
PPUL: RO07_25060
HYF: DTO96_100892(ligA_1) DTO96_100893(ligB)
AFQ: AFA_05515 AFA_05520(ligA)
LIM: L103DPR2_01497(ligA_1) L103DPR2_01498(ligB_1) L103DPR2_01514(ligA_2) L103DPR2_01515(ligB_2)
LIH: L63ED372_01144(ligA_1) L63ED372_01145(ligB)
HPSE: HPF_08080(ligA1) HPF_08085(ligB1) HPF_08185(ligA2) HPF_08190(ligB2)
DAR: Daro_3248
AZO: azo2522(ligB1) azo2523(ligA1) azo2537(ligB2) azo2538(ligA2)
BRA: BRADO2341(ligA) BRADO2342(ligB) BRADO2379 BRADO2380(mhpB)
BBT: BBta_2701(ligA) BBta_2702(ligB) BBta_2733 BBta_2734(mhpB)
BRO: BRAD285_4958(ligB) BRAD285_4959(ligA) BRAD285_4995(ligB) BRAD285_4996(ligA)
RPA: RPA1006 RPA1007(mhpB) RPA4701(ligA) RPA4702(ligB)
MMED: Mame_04593(ligB)
SPHR: BSY17_3446(ligB) BSY17_3447(ligA)
BLAS: BSY18_3523(ligA) BSY18_3524(ligB)
AAY: WYH_01045(ligB_1) WYH_01046(ligA_2) WYH_01908(ligA_3) WYH_01909(ligB_2) WYH_03214(ligB_3) WYH_03215(ligA_4)
ADO: A6F68_01079(ligB) A6F68_01080(ligA_1)
MAGX: XM1_1094 XM1_1095(ligB)
TMO: TMO_b0115(mhpB)
MAGQ: MGMAQ_2661(ligB) MGMAQ_2662(ligA) MGMAQ_2669(ligA) MGMAQ_2670(ligB)
AUW: AURUGA1_00419(ligA_1) AURUGA1_00420(ligB)
NML: Namu_0046
BSD: BLASA_2598(ligA) BLASA_2599(ligB)
MMAR: MODMU_2843(ligB) MODMU_2844(ligA) MODMU_3384
PSEA: WY02_25080
PAUT: Pdca_48140(pcaH_2) Pdca_48150
ACTN: L083_0820
AFS: AFR_03865
PFLA: Pflav_029930 Pflav_029940(pcaH_1)
AFO: Afer_2021
 » show all
Reference
1
  Authors
Trippett, S., Dagley, S. and Stopher, D.A.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
Biochem J 76:9 (1960)
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.8
IUBMB Enzyme Nomenclature: 1.13.11.8
ExPASy - ENZYME nomenclature database: 1.13.11.8
UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.8
BRENDA, the Enzyme Database: 1.13.11.8
CAS: 9029-56-5

KEGG   REACTION: R01632
Entry
R01632                      Reaction                               

Name
protocatechuate:oxygen 4,5-oxidoreductase (decyclizing)
Definition
3,4-Dihydroxybenzoate + Oxygen <=> 4-Carboxy-2-hydroxymuconate semialdehyde
Equation
Reaction class
RC00387  C00230_C04484
Enzyme
Pathway
rn00362  Benzoate degradation
rn00624  Polycyclic aromatic hydrocarbon degradation
rn00627  Aminobenzoate degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K04100  protocatechuate 4,5-dioxygenase, alpha chain [EC:1.13.11.8]
K04101  protocatechuate 4,5-dioxygenase, beta chain [EC:1.13.11.8]
Other DBs
RHEA: 24047

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