KEGG   ORTHOLOGY: K04107
Entry
K04107                      KO                                     

Name
hcrC, hbaB
Definition
4-hydroxybenzoyl-CoA reductase subunit gamma [EC:1.1.7.1]
Pathway
ko00362  Benzoate degradation
ko00627  Aminobenzoate degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K04107  hcrC, hbaB; 4-hydroxybenzoyl-CoA reductase subunit gamma
   00627 Aminobenzoate degradation
    K04107  hcrC, hbaB; 4-hydroxybenzoyl-CoA reductase subunit gamma
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.7  With an iron-sulfur protein as acceptor
    1.1.7.1  4-hydroxybenzoyl-CoA reductase
     K04107  hcrC, hbaB; 4-hydroxybenzoyl-CoA reductase subunit gamma
Other DBs
RN: R05316
GO: 0018525
Genes
EBA: ebA3604(hcrC)
AZA: AZKH_0491(hcrC)
AZI: AzCIB_0408
AZD: CDA09_02115(hcrC)
TMZ: Tmz1t_0224
TCL: Tchl_2359
TAK: Tharo_1515
RPA: RPA0670(hbaB)
RPC: RPC_1015
RPD: RPD_1525
RPE: RPE_0591
RPT: Rpal_0737
MAG: amb2019
MAGX: XM1_2739(hcrC)
MAGN: WV31_19865
AG: CAA05037(hcrC)
 » show all
Reference
PMID:9006014
  Authors
Gibson J, Dispensa M, Harwood CS
  Title
4-hydroxybenzoyl coenzyme A reductase (dehydroxylating) is required for anaerobic degradation of 4-hydroxybenzoate by Rhodopseudomonas palustris and shares features with molybdenum-containing hydroxylases.
  Journal
J Bacteriol 179:634-42 (1997)
DOI:10.1128/JB.179.3.634-642.1997
  Sequence
[rpa:RPA0670]
Reference
PMID:9490068
  Authors
Breese K, Fuchs G
  Title
4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from the denitrifying bacterium Thauera aromatica--prosthetic groups, electron donor, and genes of a member of the molybdenum-flavin-iron-sulfur proteins.
  Journal
Eur J Biochem 251:916-23 (1998)
DOI:10.1046/j.1432-1327.1998.2510916.x
  Sequence

KEGG   ORTHOLOGY: K04108
Entry
K04108                      KO                                     

Name
hcrA, hbaC
Definition
4-hydroxybenzoyl-CoA reductase subunit alpha [EC:1.1.7.1]
Pathway
ko00362  Benzoate degradation
ko00627  Aminobenzoate degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K04108  hcrA, hbaC; 4-hydroxybenzoyl-CoA reductase subunit alpha
   00627 Aminobenzoate degradation
    K04108  hcrA, hbaC; 4-hydroxybenzoyl-CoA reductase subunit alpha
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.7  With an iron-sulfur protein as acceptor
    1.1.7.1  4-hydroxybenzoyl-CoA reductase
     K04108  hcrA, hbaC; 4-hydroxybenzoyl-CoA reductase subunit alpha
Other DBs
RN: R05316
GO: 0018525
Genes
EBA: ebA3603(hcrA)
AZA: AZKH_0490(hcrA)
AZI: AzCIB_0407
AZD: CDA09_02110(hcrA)
TMZ: Tmz1t_0225
TCL: Tchl_2358
TAK: Tharo_1514
RPA: RPA0671(hbaC)
RPC: RPC_1014
RPD: RPD_1524
RPE: RPE_0590
RPT: Rpal_0738
MAG: amb2020
MAGX: XM1_2740(hcrA)
MAGN: WV31_19860
AG: CAA05038(hcrA)
 » show all
Reference
PMID:9006014
  Authors
Gibson J, Dispensa M, Harwood CS
  Title
4-hydroxybenzoyl coenzyme A reductase (dehydroxylating) is required for anaerobic degradation of 4-hydroxybenzoate by Rhodopseudomonas palustris and shares features with molybdenum-containing hydroxylases.
  Journal
J Bacteriol 179:634-42 (1997)
DOI:10.1128/JB.179.3.634-642.1997
  Sequence
[rpa:RPA0671]
Reference
PMID:9490068
  Authors
Breese K, Fuchs G
  Title
4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from the denitrifying bacterium Thauera aromatica--prosthetic groups, electron donor, and genes of a member of the molybdenum-flavin-iron-sulfur proteins.
  Journal
Eur J Biochem 251:916-23 (1998)
DOI:10.1046/j.1432-1327.1998.2510916.x
  Sequence

KEGG   ORTHOLOGY: K04109
Entry
K04109                      KO                                     

Name
hcrB, hbaD
Definition
4-hydroxybenzoyl-CoA reductase subunit beta [EC:1.1.7.1]
Pathway
ko00362  Benzoate degradation
ko00627  Aminobenzoate degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K04109  hcrB, hbaD; 4-hydroxybenzoyl-CoA reductase subunit beta
   00627 Aminobenzoate degradation
    K04109  hcrB, hbaD; 4-hydroxybenzoyl-CoA reductase subunit beta
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.7  With an iron-sulfur protein as acceptor
    1.1.7.1  4-hydroxybenzoyl-CoA reductase
     K04109  hcrB, hbaD; 4-hydroxybenzoyl-CoA reductase subunit beta
Other DBs
RN: R05316
GO: 0018525
Genes
EBA: ebA3602(hcrB)
AZA: AZKH_0489(hcrB)
AZI: AzCIB_0406
AZD: CDA09_02105(hcrB)
TMZ: Tmz1t_0226
TCL: Tchl_2357
TAK: Tharo_1513
RPA: RPA0672(hbaD)
RPC: RPC_1013
RPD: RPD_1523
RPE: RPE_0589
RPT: Rpal_0739
MAG: amb2021
MAGX: XM1_2741(hcrB)
MAGN: WV31_19855
AG: CAA05039(hcrB)
 » show all
Reference
PMID:9006014
  Authors
Gibson J, Dispensa M, Harwood CS
  Title
4-hydroxybenzoyl coenzyme A reductase (dehydroxylating) is required for anaerobic degradation of 4-hydroxybenzoate by Rhodopseudomonas palustris and shares features with molybdenum-containing hydroxylases.
  Journal
J Bacteriol 179:634-42 (1997)
DOI:10.1128/JB.179.3.634-642.1997
  Sequence
[rpa:RPA0672]
Reference
PMID:9490068
  Authors
Breese K, Fuchs G
  Title
4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from the denitrifying bacterium Thauera aromatica--prosthetic groups, electron donor, and genes of a member of the molybdenum-flavin-iron-sulfur proteins.
  Journal
Eur J Biochem 251:916-23 (1998)
DOI:10.1046/j.1432-1327.1998.2510916.x
  Sequence

KEGG   ENZYME: 1.1.7.1
Entry
EC 1.1.7.1                  Enzyme                                 

Name
4-hydroxybenzoyl-CoA reductase;
4-hydroxybenzoyl-CoA reductase (dehydroxylating);
4-hydroxybenzoyl-CoA:(acceptor) oxidoreductase;
benzoyl-CoA:acceptor oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With an iron-sulfur protein as acceptor
Sysname
benzoyl-CoA:oxidized ferredoxin oxidoreductase
Reaction(IUBMB)
benzoyl-CoA + oxidized ferredoxin + H2O = 4-hydroxybenzoyl-CoA + reduced ferredoxin [RN:R05316]
Reaction(KEGG)
R05316
Substrate
benzoyl-CoA [CPD:C00512];
oxidized ferredoxin [CPD:C00139];
H2O [CPD:C00001]
Product
4-hydroxybenzoyl-CoA [CPD:C02949];
reduced ferredoxin [CPD:C00138]
Comment
A molybdenum-flavin-iron-sulfur protein that is involved in the anaerobic pathway of phenol metabolism in bacteria. A ferredoxin with two [4Fe-4S] clusters functions as the natural electron donor [3].
History
EC 1.1.7.1 created 2000 as EC 1.3.99.20, transferred 2011 to EC 1.3.7.9, transfered 2020 to EC 1.1.7.1
Pathway
ec00362  Benzoate degradation
ec00627  Aminobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K04107  4-hydroxybenzoyl-CoA reductase subunit gamma
K04108  4-hydroxybenzoyl-CoA reductase subunit alpha
K04109  4-hydroxybenzoyl-CoA reductase subunit beta
Genes
EBA: ebA3602(hcrB) ebA3603(hcrA) ebA3604(hcrC)
AZA: AZKH_0489(hcrB) AZKH_0490(hcrA) AZKH_0491(hcrC)
AZI: AzCIB_0406 AzCIB_0407 AzCIB_0408
AZD: CDA09_02105(hcrB) CDA09_02110(hcrA) CDA09_02115(hcrC)
TMZ: Tmz1t_0224 Tmz1t_0225 Tmz1t_0226
TCL: Tchl_2357 Tchl_2358 Tchl_2359
TAK: Tharo_1513 Tharo_1514 Tharo_1515
RPA: RPA0670(hbaB) RPA0671(hbaC) RPA0672(hbaD)
RPC: RPC_1013 RPC_1014 RPC_1015
RPD: RPD_1523 RPD_1524 RPD_1525
MAGX: XM1_2739(hcrC) XM1_2740(hcrA) XM1_2741(hcrB)
 » show all
Reference
1  [PMID:2753161]
  Authors
Glockler R, Tschech A, Fuchs G.
  Title
Reductive dehydroxylation of 4-hydroxybenzoyl-CoA to benzoyl-CoA in a denitrifying, phenol-degrading Pseudomonas species.
  Journal
FEBS Lett 251:237-40 (1989)
DOI:10.1016/0014-5793(89)81461-9
Reference
2  [PMID:9683649]
  Authors
Heider J, Boll M, Breese K, Breinig S, Ebenau-Jehle C, Feil U, Gad'on N, Laempe D, Leuthner B, Mohamed ME, Schneider S, Burchhardt G, Fuchs G.
  Title
Differential induction of enzymes involved in anaerobic metabolism of aromatic compounds in the denitrifying bacterium Thauera aromatica.
  Journal
Arch Microbiol 170:120-31 (1998)
DOI:10.1007/s002030050623
Reference
3  [PMID:9490068]
  Authors
Breese K, Fuchs G.
  Title
4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from the denitrifying bacterium Thauera aromatica--prosthetic groups, electron donor, and genes of a member of the molybdenum-flavin-iron-sulfur proteins.
  Journal
Eur J Biochem 251:916-23 (1998)
DOI:10.1046/j.1432-1327.1998.2510916.x
  Sequence
Reference
4  [PMID:8477729]
  Authors
Brackmann R, Fuchs G.
  Title
Enzymes of anaerobic metabolism of phenolic compounds. 4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from a denitrifying Pseudomonas species.
  Journal
Eur J Biochem 213:563-71 (1993)
DOI:10.1111/j.1432-1033.1993.tb17795.x
Reference
5  [PMID:9057820]
  Authors
Heider J, Fuchs G.
  Title
Anaerobic metabolism of aromatic compounds.
  Journal
Eur J Biochem 243:577-96 (1997)
DOI:10.1111/j.1432-1033.1997.00577.x
Other DBs
ExplorEnz - The Enzyme Database: 1.1.7.1
IUBMB Enzyme Nomenclature: 1.1.7.1
ExPASy - ENZYME nomenclature database: 1.1.7.1
BRENDA, the Enzyme Database: 1.1.7.1
CAS: 133758-58-4

KEGG   REACTION: R05316
Entry
R05316                      Reaction                               

Name
benzoyl-CoA:acceptor oxidoreductase
Definition
4-Hydroxybenzoyl-CoA + Reduced ferredoxin <=> Benzoyl-CoA + Oxidized ferredoxin + H2O
Equation
Reaction class
RC00490  C00512_C02949
Enzyme
Pathway
rn00362  Benzoate degradation
rn00627  Aminobenzoate degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Orthology
K04107  4-hydroxybenzoyl-CoA reductase subunit gamma [EC:1.1.7.1]
K04108  4-hydroxybenzoyl-CoA reductase subunit alpha [EC:1.1.7.1]
K04109  4-hydroxybenzoyl-CoA reductase subunit beta [EC:1.1.7.1]
Other DBs
RHEA: 29606

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