KEGG   ORTHOLOGY: K04110
Entry
K04110                      KO                                     

Name
badA
Definition
benzoate-CoA ligase [EC:6.2.1.25]
Pathway
ko00362  Benzoate degradation
ko00627  Aminobenzoate degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K04110  badA; benzoate-CoA ligase
   00627 Aminobenzoate degradation
    K04110  badA; benzoate-CoA ligase
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.25  benzoate---CoA ligase
     K04110  badA; benzoate-CoA ligase
Other DBs
RN: R01422
COG: COG0365
GO: 0018858
Genes
THIS: HZT40_02665
VFF: VITFI_CDS1599
RPJ: N234_07060 N234_31305
REH: H16_A1412(h16_A1412) H16_B1918(h16_B1918)
CNC: CNE_1c14400(bclA) CNE_2c18780(bclA)
CUH: BJN34_07200 BJN34_32120
REU: Reut_A1327
RME: Rmet_1224(bzdA)
CTI: RALTA_A1325 RALTA_B1617
CBW: RR42_m1521 RR42_s3017
CGD: CR3_1586(badA) CR3_3376(badA)
BXB: DR64_3582(bclA) DR64_7554(bclA)
BPH: Bphy_1543
BFN: OI25_2711
PPNO: DA70_23835
PPNM: LV28_06875
PPUL: RO07_00960
PSPU: NA29_10705
PAPI: SG18_01135
BPT: Bpet3574
BHO: D560_2016(bclA)
BHM: D558_2001(bclA)
BHZ: ACR54_04089(bclA_1)
AXX: ERS451415_04891(bclA_4)
AMIM: MIM_c27210
RFR: Rfer_0216
PNA: Pnap_2948
VEI: Veis_0730
DAC: Daci_0076
CTES: O987_00467
RTA: Rta_22340
LIM: L103DPR2_00827(bclA_2)
LIH: L63ED372_02250(bclA_2)
HYB: Q5W_16405
CBAA: SRAA_0581
LCH: Lcho_3655
THI: THI_0472(badA)
EBA: ebA2757(bclA) ebA5301(bclA)
AZO: azo3052(bzdA)
AOA: dqs_3186
AZA: AZKH_2151(bclA) AZKH_4514(bclA)
BBT: BBta_6637(badA)
RPA: RPA0661(badA)
RPC: RPC_1025
RPD: RPD_1534
RPE: RPE_0604
RPT: Rpal_0728
RBM: TEF_07985
SWI: Swit_0829
SPHD: HY78_22550
SPHI: TS85_01660
 » show all
Reference
  Authors
Schuhle K, Gescher J, Feil U, Paul M, Jahn M, Schagger H, Fuchs G
  Title
Benzoate-coenzyme A ligase from Thauera aromatica: an enzyme acting in anaerobic and aerobic pathways.
  Journal
J Bacteriol 185:4920-9 (2003)
DOI:10.1128/jb.185.16.4920-4929.2003
  Sequence

KEGG   ORTHOLOGY: K04105
Entry
K04105                      KO                                     

Name
hbaA
Definition
4-hydroxybenzoate-CoA ligase [EC:6.2.1.27 6.2.1.25]
Pathway
ko00362  Benzoate degradation
ko00627  Aminobenzoate degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K04105  hbaA; 4-hydroxybenzoate-CoA ligase
   00627 Aminobenzoate degradation
    K04105  hbaA; 4-hydroxybenzoate-CoA ligase
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.25  benzoate---CoA ligase
     K04105  hbaA; 4-hydroxybenzoate-CoA ligase
    6.2.1.27  4-hydroxybenzoate---CoA ligase
     K04105  hbaA; 4-hydroxybenzoate-CoA ligase
Other DBs
RN: R01300 R01422
GO: 0018859 0018858
Genes
MTHD: A3224_01560
MII: BTJ40_01805
ADI: B5T_02169
CRZ: D1345_21875
CHAE: CH06BL_45340
PBH: AAW51_0206(badA)
SUR: STAUR_3224
MESO: BSQ44_18050
RPOD: E0E05_11160
NIY: FQ775_02940
BJA: blr1077
BRA: BRADO6791
BBT: BBta_0747
BRS: S23_67390
AOL: S58_06690
RPA: RPA0669(hbaA)
RPB: RPB_4656
RPC: RPC_1016
RPE: RPE_0592
RPT: Rpal_0736
VGO: GJW-30_1_01037(hbaA)
SIL: SPO3697(badA-1)
JAN: Jann_0669
LABT: FIU93_06225(bclA1)
SPSE: SULPSESMR1_02749(hbaA)
RID: RIdsm_00622(hbaA_1)
AHT: ANTHELSMS3_04347(prpE)
MALU: KU6B_38090
MAG: amb2869
MAGX: XM1_2792(bclA)
MAGN: WV31_19615
 » show all
Reference
PMID:9006014
  Authors
Gibson J, Dispensa M, Harwood CS
  Title
4-hydroxybenzoyl coenzyme A reductase (dehydroxylating) is required for anaerobic degradation of 4-hydroxybenzoate by Rhodopseudomonas palustris and shares features with molybdenum-containing hydroxylases.
  Journal
J Bacteriol 179:634-42 (1997)
DOI:10.1128/JB.179.3.634-642.1997
Reference
PMID:8300518
  Authors
Gibson J, Dispensa M, Fogg GC, Evans DT, Harwood CS
  Title
4-Hydroxybenzoate-coenzyme A ligase from Rhodopseudomonas palustris: purification, gene sequence, and role in anaerobic degradation.
  Journal
J Bacteriol 176:634-41 (1994)
DOI:10.1128/JB.176.3.634-641.1994
  Sequence
[rpa:RPA0669]

KEGG   ENZYME: 6.2.1.25
Entry
EC 6.2.1.25                 Enzyme                                 

Name
benzoate---CoA ligase;
benzoate---coenzyme A ligase;
benzoyl-coenzyme A synthetase;
benzoyl CoA synthetase (AMP forming)
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
benzoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + benzoate + CoA = AMP + diphosphate + benzoyl-CoA [RN:R01422]
Reaction(KEGG)
R01422
Substrate
ATP [CPD:C00002];
benzoate [CPD:C00180];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
benzoyl-CoA [CPD:C00512]
Comment
Also acts on 2-, 3- and 4-fluorobenzoate, but only very slowly on the corresponding chlorobenzoates.
History
EC 6.2.1.25 created 1989
Pathway
ec00362  Benzoate degradation
ec00627  Aminobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K04105  4-hydroxybenzoate-CoA ligase
K04110  benzoate-CoA ligase
K23108  benzoate---CoA ligase
Genes
ATH: AT1G65880(BZO1)
MTHD: A3224_01560
MII: BTJ40_01805
THIS: HZT40_02665
ADI: B5T_02169
VFF: VITFI_CDS1599
CRZ: D1345_21875
CHAE: CH06BL_45340
RPJ: N234_07060 N234_31305
REH: H16_A1412(h16_A1412) H16_B1918(h16_B1918)
CNC: CNE_1c14400(bclA) CNE_2c18780(bclA)
RME: Rmet_1224(bzdA)
CGD: CR3_1586(badA) CR3_3376(badA)
BXB: DR64_3582(bclA) DR64_7554(bclA)
BPH: Bphy_1543
BFN: OI25_2711
PPNO: DA70_23835
PPNM: LV28_06875
PPUL: RO07_00960
PSPU: NA29_10705
PAPI: SG18_01135
BPT: Bpet3574
BHO: D560_2016(bclA)
BHM: D558_2001(bclA)
BHZ: ACR54_04089(bclA_1)
AXX: ERS451415_04891(bclA_4)
AMIM: MIM_c27210
RFR: Rfer_0216
PNA: Pnap_2948
VEI: Veis_0730
DAC: Daci_0076
CTES: O987_00467
RTA: Rta_22340
LIM: L103DPR2_00827(bclA_2)
LIH: L63ED372_02250(bclA_2)
HYB: Q5W_16405
CBAA: SRAA_0581
LCH: Lcho_3655
THI: THI_0472(badA)
PBH: AAW51_0206(badA)
EBA: ebA2757(bclA) ebA5301(bclA)
AZO: azo3052(bzdA)
AOA: dqs_3186
AZA: AZKH_2151(bclA) AZKH_4514(bclA)
BJA: blr1077
BRA: BRADO6791
BBT: BBta_0747 BBta_6637(badA)
BRS: S23_67390
AOL: S58_06690
RPA: RPA0661(badA) RPA0669(hbaA)
RPB: RPB_4656
VGO: GJW-30_1_01037(hbaA)
RBM: TEF_07985
SIL: SPO3697(badA-1)
JAN: Jann_0669
LABT: FIU93_06225(bclA1)
SPSE: SULPSESMR1_02749(hbaA)
RID: RIdsm_00622(hbaA_1)
AHT: ANTHELSMS3_04347(prpE)
MALU: KU6B_38090
SWI: Swit_0829
SPHD: HY78_22550
SPHI: TS85_01660
MAG: amb2869
MAGX: XM1_2792(bclA)
MAGN: WV31_19615
 » show all
Reference
1
  Authors
Hutber, G.N. and Ribbons, D.W.
  Title
Involvement of coenzyme-A esters in the metabolism of benzoate and cyclohexanecarboxylate by Rhodopseudomonas palustris.
  Journal
J Gen Microbiol 129:2413-2420 (1983)
Reference
2  [PMID:2857161]
  Authors
Schennen U, Braun K, Knackmuss HJ.
  Title
Anaerobic degradation of 2-fluorobenzoate by benzoate-degrading, denitrifying bacteria.
  Journal
J Bacteriol 161:321-5 (1985)
DOI:10.1128/JB.161.1.321-325.1985
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.25
IUBMB Enzyme Nomenclature: 6.2.1.25
ExPASy - ENZYME nomenclature database: 6.2.1.25
UM-BBD (Biocatalysis/Biodegradation Database): 6.2.1.25
BRENDA, the Enzyme Database: 6.2.1.25
CAS: 95329-17-2

KEGG   REACTION: R01422
Entry
R01422                      Reaction                               

Name
benzoate:CoA ligase (AMP-forming)
Definition
ATP + Benzoate + CoA <=> AMP + Diphosphate + Benzoyl-CoA
Equation
Reaction class
RC00004  C00010_C00512
RC00174  C00180_C00512
Enzyme
Pathway
rn00362  Benzoate degradation
rn00627  Aminobenzoate degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K04105  4-hydroxybenzoate-CoA ligase [EC:6.2.1.27 6.2.1.25]
K04110  benzoate-CoA ligase [EC:6.2.1.25]
Other DBs
RHEA: 10135

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