KEGG   ORTHOLOGY: K04128Help
Entry
K04128                      KO                                     

Name
cmcH
Definition
hydroxymethyl cephem carbamoyltransferase [EC:2.1.3.7]
Pathway
ko00311  Penicillin and cephalosporin biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00673  Cephamycin C biosynthesis, aminoadipate + cycteine + valine => cephamycin C
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00311 Penicillin and cephalosporin biosynthesis
    K04128  cmcH; hydroxymethyl cephem carbamoyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.3  Carboxy- and carbamoyltransferases
    2.1.3.7  3-hydroxymethylcephem carbamoyltransferase
     K04128  cmcH; hydroxymethyl cephem carbamoyltransferase
BRITE hierarchy
Other DBs
RN: R05230
GO: 0047155
Genes
YEE: YE5303_29981
YAL: AT01_3057
RSO: RSp1487(cmcH)
RSL: RPSI07_2714 RPSI07_mp0876(cmcH)
RSN: RSPO_c02723(cmcH) RSPO_m00518
RSE: F504_4958
BGF: BC1003_2995
BGD: bgla_4p2750
BUZ: AYM40_00960
RFR: Rfer_3660
REL: REMIM1_PE00060(cmcH)
SWI: Swit_4991
SCT: SCAT_5682(cmcH)
AOI: AORI_3162(cmcH)
AJA: AJAP_23550(cmcH)
ACTI: UA75_17670
ACAD: UA74_17130
MIL: ML5_4153
 » show all
TaxonomyKoalaUniProt

KEGG   ENZYME: 2.1.3.7Help
Entry
EC 2.1.3.7                  Enzyme                                 

Name
3-hydroxymethylcephem carbamoyltransferase
Class
Transferases;
Transferring one-carbon groups;
Carboxy- and carbamoyltransferases
BRITE hierarchy
Sysname
carbamoyl-phosphate:3-hydroxymethylceph-3-em-4-carboxylate carbamoyltransferase
Reaction(IUBMB)
carbamoyl phosphate + a 3-hydroxymethylceph-3-em-4-carboxylate = phosphate + a 3-carbamoyloxymethylcephem [RN:R04281]
Reaction(KEGG)
Substrate
carbamoyl phosphate [CPD:C00169];
3-hydroxymethylceph-3-em-4-carboxylate
Product
phosphate [CPD:C00009];
3-carbamoyloxymethylcephem [CPD:C03674]
Comment
Acts on a wide range of 3-hydroxymethylcephems (a subclass of the cephalosporin antibiotics). Activated by ATP.
History
EC 2.1.3.7 created 1983
Pathway
ec00311  Penicillin and cephalosporin biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K04128  hydroxymethyl cephem carbamoyltransferase
Genes
YEE: YE5303_29981
YAL: AT01_3057
RSO: RSp1487(cmcH)
RSL: RPSI07_2714 RPSI07_mp0876(cmcH)
RSN: RSPO_c02723(cmcH) RSPO_m00518
RSE: F504_4958
BGF: BC1003_2995
BGD: bgla_4p2750
BUZ: AYM40_00960
RFR: Rfer_3660
REL: REMIM1_PE00060(cmcH)
SWI: Swit_4991
SCT: SCAT_5682(cmcH)
AOI: AORI_3162(cmcH)
AJA: AJAP_23550(cmcH)
ACTI: UA75_17670
ACAD: UA74_17130
MIL: ML5_4153
 » show all
Taxonomy
Reference
1  [PMID:6248024]
  Authors
Brewer SJ, Taylor PM, Turner MK.
  Title
An adenosine triphosphate-dependent carbamoylphosphate--3-hydroxymethylcephem O-carbamoyltransferase from Streptomyces clavuligerus.
  Journal
Biochem J 185:555-64 (1980)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.3.7
IUBMB Enzyme Nomenclature: 2.1.3.7
ExPASy - ENZYME nomenclature database: 2.1.3.7
BRENDA, the Enzyme Database: 2.1.3.7
CAS: 74315-96-1

KEGG   REACTION: R05230Help
Entry
R05230                      Reaction                               

Definition
Deacetylcephalosporin C + Carbamoyl phosphate <=> O-Carbamoyl-deacetylcephalosporin C + Orthophosphate
Equation
Reaction class
RC00041  C03112_C06568
Enzyme
Pathway
rn00311  Penicillin and cephalosporin biosynthesis
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00673  Cephamycin C biosynthesis, aminoadipate + cycteine + valine => cephamycin C
Orthology
K04128  hydroxymethyl cephem carbamoyltransferase [EC:2.1.3.7]

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