KEGG   ORTHOLOGY: K04340
Entry
K04340                      KO                                     

Name
strB1
Definition
scyllo-inosamine-4-phosphate amidinotransferase 1 [EC:2.1.4.2]
Pathway
ko00521  Streptomycin biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00521 Streptomycin biosynthesis
    K04340  strB1; scyllo-inosamine-4-phosphate amidinotransferase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.4  Amidinotransferases
    2.1.4.2  scyllo-inosamine-4-phosphate amidinotransferase
     K04340  strB1; scyllo-inosamine-4-phosphate amidinotransferase 1
Other DBs
RN: R03477
GO: 0015069
Genes
SGR: SGR_5933(strB1)
SBH: SBI_00621
SGU: SGLAU_01160(strB1)
SFIC: EIZ62_06155

KEGG   ENZYME: 2.1.4.2
Entry
EC 2.1.4.2                  Enzyme                                 

Name
scyllo-inosamine-4-phosphate amidinotransferase;
L-arginine:inosamine-P-amidinotransferase;
inosamine-P amidinotransferase;
L-arginine:inosamine phosphate amidinotransferase;
inosamine-phosphate amidinotransferase
Class
Transferases;
Transferring one-carbon groups;
Amidinotransferases
Sysname
L-arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amidinotransferase
Reaction(IUBMB)
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate = L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate [RN:R03477]
Reaction(KEGG)
R03477
Substrate
L-arginine [CPD:C00062];
1-amino-1-deoxy-scyllo-inositol 4-phosphate [CPD:C01283]
Product
L-ornithine [CPD:C00077];
1-guanidino-1-deoxy-scyllo-inositol 4-phosphate [CPD:C01294]
Comment
1D-1-Guanidino-3-amino-1,3-dideoxy-scyllo-inositol 6-phosphate, streptamine phosphate and 2-deoxystreptamine phosphate can also act as acceptors; canavanine can act as donor.
History
EC 2.1.4.2 created 1976, modified 2001
Pathway
ec00521  Streptomycin biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K04340  scyllo-inosamine-4-phosphate amidinotransferase 1
Genes
SGR: SGR_5933(strB1)
SBH: SBI_00621
SGU: SGLAU_01160(strB1)
SFIC: EIZ62_06155
Reference
1  [PMID:5935341]
  Authors
Walker MS, Walker JB.
  Title
Enzymic studies on the biosynthesis of streptomycin. Transamidination of inosamine and streptamine derivatives.
  Journal
J Biol Chem 241:1262-70 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.4.2
IUBMB Enzyme Nomenclature: 2.1.4.2
ExPASy - ENZYME nomenclature database: 2.1.4.2
BRENDA, the Enzyme Database: 2.1.4.2
CAS: 52227-63-1

KEGG   REACTION: R03477
Entry
R03477                      Reaction                               

Name
L-Arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amindinotransferase
Definition
L-Arginine + 1-Amino-1-deoxy-scyllo-inositol 4-phosphate <=> L-Ornithine + 1-Guanidino-1-deoxy-scyllo-inositol 4-phosphate
Equation
Reaction class
RC00024  C00062_C00077
RC00939  C01283_C01294
Enzyme
Pathway
rn00521  Streptomycin biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K04340  scyllo-inosamine-4-phosphate amidinotransferase 1 [EC:2.1.4.2]
Other DBs
RHEA: 13268

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