KEGG   ORTHOLOGY: K04342
Entry
K04342                      KO                                     

Name
strK
Definition
streptomycin-6-phosphatase [EC:3.1.3.39]
Pathway
ko00521  Streptomycin biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00521 Streptomycin biosynthesis
    K04342  strK; streptomycin-6-phosphatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.39  streptomycin-6-phosphatase
     K04342  strK; streptomycin-6-phosphatase
Other DBs
RN: R02228
GO: 0050301
Genes
SGR: SGR_5938(strK)
SCT: SCAT_5710(strK)
SCY: SCATT_57100
SBH: SBI_00130
SRC: M271_11895
SGU: SGLAU_01170(strK)
SLD: T261_3818
SRN: A4G23_04371(phoA)
STRT: A8713_16450
SVU: B1H20_31850
SALJ: SMD11_2283(strK)
 » show all

KEGG   ENZYME: 3.1.3.39
Entry
EC 3.1.3.39                 Enzyme                                 

Name
streptomycin-6-phosphatase;
streptomycin 6-phosphate phosphatase;
streptomycin 6-phosphate phosphohydrolase;
streptomycin-6-P phosphohydrolase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
streptomycin-6-phosphate phosphohydrolase
Reaction(IUBMB)
streptomycin 6-phosphate + H2O = streptomycin + phosphate [RN:R02228]
Reaction(KEGG)
R02228
Substrate
streptomycin 6-phosphate [CPD:C01138];
H2O [CPD:C00001]
Product
streptomycin [CPD:C00413];
phosphate [CPD:C00009]
Comment
Also acts on dihydrostreptomycin 3'alpha,6-bisphosphate and streptidine 6-phosphate.
History
EC 3.1.3.39 created 1976
Pathway
ec00521  Streptomycin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K04342  streptomycin-6-phosphatase
Genes
SGR: SGR_5938(strK)
SCT: SCAT_5710(strK)
SCY: SCATT_57100
SBH: SBI_00130
SRC: M271_11895
SGU: SGLAU_01170(strK)
SLD: T261_3818
SRN: A4G23_04371(phoA)
STRT: A8713_16450
SVU: B1H20_31850
SALJ: SMD11_2283(strK)
 » show all
Reference
1  [PMID:4121457]
  Authors
Walker JB, Skorvaga M.
  Title
Streptomycin biosynthesis and metabolism. Phosphate transfer from dihydrostreptomycin 6-phosphate to inosamines, streptamine, and 2-deoxystreptamine.
  Journal
J Biol Chem 248:2441-6 (1973)
Reference
2  [PMID:4331203]
  Authors
Walker MS, Walker JB.
  Title
Streptomycin biosynthesis. Separation and substrate specificities of phosphatases acting on guanidinodeoxy-scyllo-inositol phosphate and streptomycin-(streptidino)phosphate.
  Journal
J Biol Chem 246:7034-40 (1971)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.39
IUBMB Enzyme Nomenclature: 3.1.3.39
ExPASy - ENZYME nomenclature database: 3.1.3.39
BRENDA, the Enzyme Database: 3.1.3.39
CAS: 9055-33-8

KEGG   REACTION: R02228
Entry
R02228                      Reaction                               

Name
Streptomycin-6-phosphate phosphohydrolase
Definition
Streptomycin 6-phosphate + H2O <=> Streptomycin + Orthophosphate
Equation
Reaction class
RC00078  C00413_C01138
Enzyme
Pathway
rn00521  Streptomycin biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K04342  streptomycin-6-phosphatase [EC:3.1.3.39]
Other DBs
RHEA: 10691

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