KEGG ORTHOLOGY: K04351

ORTHOLOGY: K04351

Entry

K04351                      KO

Symbol

RAPGEF4, EPAC2

Name

Rap guanine nucleotide exchange factor 4

Pathway

map04015

Rap1 signaling pathway

map04024

cAMP signaling pathway

map04072

Phospholipase D signaling pathway

map04261

Adrenergic signaling in cardiomyocytes

map04670

Leukocyte transendothelial migration

map04911

Insulin secretion

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
   04072 Phospholipase D signaling pathway
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
   04024 cAMP signaling pathway
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
  09152 Endocrine system
   04911 Insulin secretion
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
Membrane trafficking [BR:ko04131]
Endoplasmic reticulum (ER) - Golgi transport
  Forward pathways
   Rab associated proteins
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4

Genes

HSA:	11069(RAPGEF4)

PTR:	459744(RAPGEF4)

PPS:	100995002(RAPGEF4)

GGO:	101151388(RAPGEF4)

PON:	100189911(RAPGEF4)

PPYG:

129031142(RAPGEF4)

NLE:	100602878(RAPGEF4)

HMH:	116810653(RAPGEF4)

SSYN:

129488054(RAPGEF4)

MCC:	698148(RAPGEF4)

MCF:	101865166(RAPGEF4)

MTHB:

126932480

MNI:	105483229(RAPGEF4)

CSAB:

103217330(RAPGEF4)

CATY:

105579810(RAPGEF4)

PANU:

100997024(RAPGEF4)

TGE:	112636245(RAPGEF4)

MLEU:

105548062(RAPGEF4)

RRO:	104673512(RAPGEF4)

RBB:	108518542(RAPGEF4)

TFN:	117094851(RAPGEF4)

PTEH:

111522172(RAPGEF4)

CANG:

105514542

CJC:	100401754(RAPGEF4)

SBQ:	101043595(RAPGEF4)

CIMI:

108310986(RAPGEF4)

ANAN:

105724053(RAPGEF4)

CSYR:

103267141(RAPGEF4)

MMUR:

105880732(RAPGEF4)

LCAT:

123644044(RAPGEF4)

PCOQ:

105815593(RAPGEF4)

OGA:	100944201(RAPGEF4)

MMU:	56508(Rapgef4)

MCAL:

110289761(Rapgef4)

MPAH:

110318780(Rapgef4)

RNO:	252857(Rapgef4)

MCOC:

116090303(Rapgef4)

ANU:	117703098(Rapgef4)

MUN:	110554362(Rapgef4)

CGE:

100774346

MAUA:

101839349(Rapgef4)

PROB:

127222420(Rapgef4)

PLEU:

114704477(Rapgef4)

MORG:

121433185(Rapgef4) 121439272

MFOT:

126489701

AAMP:

119819683(Rapgef4)

NGI:	103751742(Rapgef4)

HGL:	101706913(Rapgef4)

CPOC:

100730964(Rapgef4)

CCAN:

109687932(Rapgef4)

DORD:

105996072(Rapgef4)

DSP:	122120106(Rapgef4)

PLOP:

125350552(Rapgef4)

NCAR:

124978987

MMMA:

107136927(Rapgef4)

OCU:

100348394

OPI:	101534512(RAPGEF4)

TUP:	102485451(RAPGEF4)

GVR:

103586837

CFA:	488402(RAPGEF4)

CLUD:

112668098(RAPGEF4)

VVP:	112916400(RAPGEF4)

VLG:	121471317(RAPGEF4)

NPO:	129498672(RAPGEF4)

AML:	100480097(RAPGEF4)

UMR:	103659569(RAPGEF4)

UAH:	113250770(RAPGEF4)

UAR:	123780680(RAPGEF4)

ELK:

111158917

LLV:

125095734

MPUF:

101683321(RAPGEF4)

MNP:	132013837(RAPGEF4)

MLK:	131827087(RAPGEF4)

NVS:	122902598(RAPGEF4)

ORO:	101382059(RAPGEF4)

EJU:	114223796(RAPGEF4)

ZCA:	113919486(RAPGEF4)

MLX:	118012324(RAPGEF4)

NSU:	110592242(RAPGEF4)

LWW:	102748988(RAPGEF4)

FCA:	101092955(RAPGEF4)

PYU:	121030705(RAPGEF4)

PCOO:

112848530(RAPGEF4)

PBG:	122481463(RAPGEF4)

PVIV:

125172826(RAPGEF4)

LRUF:

124515318

PTG:	102959994(RAPGEF4)

PPAD:

109273039

PUC:

125911545

AJU:

106987935

HHV:	120236410(RAPGEF4)

BTA:	537312(RAPGEF4)

BOM:	102264805(RAPGEF4)

BIU:	109566435(RAPGEF4)

BBUB:

102396497(RAPGEF4)

BBIS:

104991386(RAPGEF4)

CHX:	102184383(RAPGEF4)

OAS:	101112196(RAPGEF4)

BTAX:

128043585(RAPGEF4)

ODA:	120854931(RAPGEF4)

CCAD:

122453597(RAPGEF4)

MBEZ:

129537653(RAPGEF4)

SSC:	100511786(RAPGEF4)

CFR:	102519185(RAPGEF4)

CBAI:

105073438(RAPGEF4)

CDK:	105091096(RAPGEF4)

VPC:	102528724(RAPGEF4)

BACU:

103018315(RAPGEF4)

BMUS:

118898159(RAPGEF4)

LVE:	103078675(RAPGEF4)

OOR:	101271995(RAPGEF4)

DLE:	111172871(RAPGEF4)

PCAD:

102985646(RAPGEF4)

PSIU:

116757044(RAPGEF4)

NASI:

112391501(RAPGEF4)

ECB:	100064121(RAPGEF4)

EPZ:	103559592(RAPGEF4)

EAI:	106834741(RAPGEF4)

MYB:	102262528(RAPGEF4)

MYD:	102765492(RAPGEF4)

MMYO:

118661427(RAPGEF4)

MLF:	102423839(RAPGEF4)

MDT:	132238527(RAPGEF4)

PKL:	118709358(RAPGEF4)

EFUS:

103283310(RAPGEF4)

MNA:	107531114(RAPGEF4)

DRO:	112305728(RAPGEF4)

SHON:

118985700(RAPGEF4)

AJM:

119053630

PDIC:

114494369(RAPGEF4)

PHAS:

123805328(RAPGEF4)

MMF:	118625354(RAPGEF4)

PPAM:

129061838(RAPGEF4)

HAI:	109388735(RAPGEF4)

RFQ:	117026182(RAPGEF4)

PALE:

102884268

PGIG:

120596952(RAPGEF4)

PVP:	105290355(RAPGEF4)

RAY:	107505164(RAPGEF4)

MJV:	108395539(RAPGEF4)

TOD:	119255936(RAPGEF4)

SARA:

101558391(RAPGEF4)

SETR:

126009160(RAPGEF4)

LAV:	100660747(RAPGEF4)

TMU:

101341572

ETF:	101661303(RAPGEF4)

DNM:	101440135(RAPGEF4)

MDO:	100025283(RAPGEF4)

GAS:	123242207(RAPGEF4)

SHR:	100933298(RAPGEF4)

AFZ:

127557765

PCW:	110211578(RAPGEF4)

TVP:	118837614(RAPGEF4)

OAA:	100084234(RAPGEF4)

GGA:	429022(RAPGEF4)

PCOC:

116232848(RAPGEF4)

MGP:	100550956 100551109

CJO:	107316695(RAPGEF4)

TPAI:

128077013(RAPGEF4)

LMUT:

125696707(RAPGEF4)

NMEL:

110399900(RAPGEF4)

APLA:

101803499(RAPGEF4)

ACYG:

106029998(RAPGEF4)

CATA:

118258884(RAPGEF4)

AFUL:

116490762(RAPGEF4)

TGU:	100231316(RAPGEF4)

LSR:	110482918(RAPGEF4)

SCAN:

103814439(RAPGEF4)

PMOA:

120497563(RAPGEF4)

OTC:	121335480(RAPGEF4)

PRUF:

121356710(RAPGEF4)

GFR:	102033413(RAPGEF4)

FAB:	101808736(RAPGEF4)

OMA:	130255658(RAPGEF4)

PHI:	102102247(RAPGEF4)

PMAJ:

107207670(RAPGEF4)

CCAE:

111932077(RAPGEF4)

CCW:	104693870(RAPGEF4)

CBRC:

103616563(RAPGEF4)

ETL:	114054913(RAPGEF4)

ZAB:	102069630(RAPGEF4)

ZLE:	135450095(RAPGEF4)

SVG:	106855496(RAPGEF4)

MMEA:

130572172(RAPGEF4)

HRT:	120754971(RAPGEF4)

SATI:

136363500(RAPGEF4)

FPG:	101910581(RAPGEF4)

FCH:	102051155(RAPGEF4)

CCRI:

104157562(RAPGEF4)

NNT:	104401272(RAPGEF4)

SHAB:

115607922(RAPGEF4)

ACUN:

113482011(RAPGEF4)

TALA:

104359765(RAPGEF4)

ACHC:

115342849(RAPGEF4)

HALD:

104322661(RAPGEF4)

HLE:	104831200(RAPGEF4)

AGEN:

126043551

GCL:

127018187

CSTI:

104553476(RAPGEF4)

LDI:	104343627(RAPGEF4)

MNB:	103775971(RAPGEF4)

DPUB:

104305755(RAPGEF4)

AVIT:

104278781(RAPGEF4)

EGZ:	104128060(RAPGEF4)

NNI:	104010004(RAPGEF4)

PCRI:

104035177

PCAO:

104041757(RAPGEF4)

PADL:

103924207(RAPGEF4)

AFOR:

103898333(RAPGEF4)

FGA:	104075741(RAPGEF4)

GSTE:

104262313(RAPGEF4)

CLV:	102085464(RAPGEF4)

MUI:	104541519(RAPGEF4)

PGUU:

104464280(RAPGEF4)

EHS:	104511936(RAPGEF4)

CMAC:

104475986(RAPGEF4)

CUCA:

104054567(RAPGEF4)

BREG:

104638361(RAPGEF4)

OHA:	104328968(RAPGEF4)

ACAR:

104521139(RAPGEF4)

CPEA:

104387393(RAPGEF4)

CVF:	104294877(RAPGEF4)

RTD:	128912585(RAPGEF4)

AAM:	106499302(RAPGEF4)

AROW:

112963929(RAPGEF4)

NPD:	112950323(RAPGEF4)

TGT:	104574482(RAPGEF4)

DNE:	112979077(RAPGEF4)

SCAM:

104148529(RAPGEF4)

ASN:	102376494(RAPGEF4)

AMJ:	102568614(RAPGEF4)

CPOO:

109323037(RAPGEF4)

GGN:	109301694(RAPGEF4)

PSS:	102444117(RAPGEF4)

CMY:	102944298(RAPGEF4)

CCAY:

125644871(RAPGEF4)

DCC:	119863573(RAPGEF4)

CPIC:

101939565(RAPGEF4)

TST:	117884859(RAPGEF4)

CABI:

116827216(RAPGEF4)

MRV:	120374757(RAPGEF4)

ACS:	100567156(rapgef4)

ASAO:

132776970(RAPGEF4)

PVT:	110088585(RAPGEF4)

SUND:

121928870(RAPGEF4)

PBI:	103053910(RAPGEF4)

PMUR:

107290439(RAPGEF4)

CTIG:

120316341(RAPGEF4)

TSR:	106551336(RAPGEF4)

PGUT:

117671562(RAPGEF4)

APRI:

131201982(RAPGEF4)

PTEX:

113434185(RAPGEF4)

NSS:	113418704(RAPGEF4)

VKO:	123017010(RAPGEF4)

PMUA:

114606886(RAPGEF4)

PRAF:

128398388(RAPGEF4)

ZVI:	118094642(RAPGEF4)

HCG:	128332163(RAPGEF4)

GJA:	107107055(RAPGEF4)

STOW:

125426059(RAPGEF4)

EMC:	129323994(RAPGEF4)

XLA:	108701373(rapgef4.L) 108702995(rapgef4.S)

XTR:	100497690(rapgef4)

NPR:	108800352(RAPGEF4)

RTEM:

120944439(RAPGEF4)

BBUF:

121008125

BGAR:

122944653(RAPGEF4)

MUO:	115474722(RAPGEF4)

GSH:	117361565(RAPGEF4)

DRE:	559170(rapgef4)

SRX:	107718455 107742951 107752096 107753902

SANH:

107657351(rapgef4) 107659975 107671325 107678227

SGH:	107551930 107581390 107588249 107602296

CCAR:

109060408 109060410 109105477

CAUA:

113050934 113053515 113091381 113109117(rapgef4)

CGIB:

127960269 127965430 128015343 128019598

PTET:

122346688(rapgef4b) 122351193

LROH:

127167219(rapgef4b) 127171230(rapgef4a)

OMC:	131542994(rapgef4b) 131547186(rapgef4a)

PPRM:

120459799(rapgef4a) 120491575(rapgef4b)

RKG:	130078027(rapgef4a) 130101256

MAMB:

125269808(rapgef4a) 125274151(rapgef4b)

CIDE:

127514703 127518416

CERY:

137011736(rapgef4b) 137035568(rapgef4a)

MASI:

127446678 127446825 127448371 127449171

TROS:

130555827(rapgef4a) 130556503(rapgef4b)

TDW:	130425099(rapgef4b) 130427164(rapgef4a)

MANU:

129450276 129451945(rapgef4a)

IPU:	108266644(rapgef4a)

IFU:	128608878(rapgef4a)

PHYP:

113525881(rapgef4)

SMEO:

124383164(rapgef4a)

TFD:	113654530(rapgef4a)

TVC:	132850221(rapgef4a)

TRN:	134316985(rapgef4b) 134324711(rapgef4a)

AMEX:

103032232(rapgef4b) 103034068(rapgef4a)

CMAO:

118805561(rapgef4a) 118808073(rapgef4b)

EEE:	113580024 113588392(rapgef4)

CHAR:

105901602(rapgef4a) 122130829

TRU:	101065114(rapgef4) 101070245

TFS:	130526728(rapgef4a) 130538422

TNG:	GSTEN00020951G001 GSTEN00031438G001

LCO:	104927784(rapgef4) 104932605

NCC:	104955735 104966264

TBEN:

117480967(rapgef4) 117488461

CGOB:

115022857 115026764(rapgef4)

PGEO:

117462889 117467004(rapgef4)

GACU:

117532676 117544418(rapgef4)

EMAC:

134865777 134867810(rapgef4a)

ELY:	117251637(rapgef4) 117272549

EFO:	125899934(rapgef4a) 125902486

PLEP:

121948803(rapgef4a) 121951212

SLUC:

116037213 116048428(rapgef4a)

ECRA:

117952605(rapgef4) 117953716

ESP:	116697608(rapgef4) 116698831

PFLV:

114564554(rapgef4) 114564996

GAT:	120816034 120834404(rapgef4a)

PPUG:

119209246 119228636(rapgef4a)

AFB:	129104187(rapgef4a) 129112767

CLUM:

117746382 117750235(rapgef4)

PSWI:

130197844 130201454(rapgef4a)

MSAM:

119902204 119904105(rapgef4a)

SCHU:

122885530(rapgef4a) 122886329

CUD:	121519779 121522485(rapgef4a)

ALAT:

119011472 119025409(rapgef4a)

MZE:	101472391 101483582

ONL:	100689894 100695746(rapgef4)

OAU:	116316203 116322950(rapgef4a)

OLA:	101160608 101167824

OML:	112147447 112155522(rapgef4a)

CSAI:

133445937(rapgef4a) 133451916

XMA:	102217330 102228535(rapgef4)

XCO:	114146798 114148913

XHE:	116721841 116723656

PRET:

103458407 103479350

PFOR:

103134298(rapgef4) 103147034

PLAI:

106946958(rapgef4) 106961733

PMEI:

106905601 106930772

GAF:	122839682(rapgef4a) 122841093

PPRL:

129361427(rapgef4a) 129362135

CVG:	107085744 107091853(rapgef4)

CTUL:

119773841 119797528(rapgef4a)

GMU:	124869392 124871919(rapgef4a)

NFU:	107384114 107390013(rapgef4)

KMR:	108239540 108239698(rapgef4a)

ALIM:

106512861 106526166

NWH:	119414635 119419154(rapgef4a)

AOCE:

111576806 111582170

MCEP:

125011243 125017392(rapgef4a)

CSEM:

103391849 103395904

POV:	109631150 109642976

SSEN:

122765254(rapgef4a) 122771580

HHIP:

117755448(rapgef4) 117777823

HSP:	118118428 118120570(rapgef4a)

PPLT:

128454606 128456339(rapgef4a)

SMAU:

118283145(rapgef4a) 118311753

LCF:	108883636 108888702(rapgef4a)

SDU:	111218206(rapgef4) 111228847

SLAL:

111668523(rapgef4) 111671130

XGL:	120798593 120801397(rapgef4a)

HCQ:	109507461 109507910(rapgef4)

SSCV:

125973369 125985124

SBIA:

133511524 133512504(rapgef4a)

PEE:	133410505(rapgef4a) 133411895

PTAO:

133487225(rapgef4a) 133488788

BPEC:

110166573(rapgef4) 110173508

MALB:

109958072(rapgef4) 109969253

BSPL:

114843849 114847209(rapgef4a)

SJO:	128367479(rapgef4a) 128368569

SASA:

106569502(rapgef4) 106581759 106586233 106600087

STRU:

115156011 115157370 115160763 115169445

OTW:	112224179 112225240 112226664 112260806

OMY:	110501447(rapgef4a) 110509209 110520113 110530658

OGO:	124041551 124043170(rapgef4a) 124043863

ONE:	115102745 115102844(rapgef4) 115109130 115114721

OKI:	109866706 109871314 109872094 109875107

OKE:	118367067 118386046(rapgef4a) 118395028 118402498

SALP:

111959839 111975159 111979745 112072432

SNH:	120020596 120055392 120057870 120064388(rapgef4a)

CCLU:

121535525 121536783 121552494 121581168

ELS:	105007217 105016205(rapgef4)

SFM:	108920347 108920713(rapgef4)

PKI:	111838585 111840792

AANG:

118223290(rapgef4)

LOC:	102688111(rapgef4)

PSPA:

121321946 121323653

ARUT:

117414305 117426178

PSEX:

120530676(rapgef4a)

LCM:	102366727(RAPGEF4)

CMK:	103176454(rapgef4a)

CPLA:

122551557(rapgef4a)

HOC:	132808965(rapgef3) 132817610(rapgef4a)

LERI:

129698745(rapgef4a)

PMRN:

116938521(RAPGEF4)

LRJ:	133346121(RAPGEF4)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

ARUN:

AJC:

SKO:

DME:	Dmel_CG34392(Epac)

DER:

6540983

DSI:	Dsimw501_GD10302(Dsim_GD10302)

DYA:	Dyak_GE24498

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI20231

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:	105230672 105230727

RZE:

108360130

AOQ:

129244441

TDA:	119678298 119678299

MDE:	101899941 131801359

SCAC:

LCQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ017680

CPII:

CNS:

BCOO:

TCA:

DPA:

SOY:

AGRG:

ATD:

AGB:

LDC:

NVL:

PPYR:

OTU:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:	103514638 103517552

CLEC:

106668425

HHAL:

106682206(Epac)

NLU:	111055288 120355727

HVI:

124366216

MQU:

129002617

PHU:	Phum_PHUM523770

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_210921

DMK:

DPZ:

PVM:

PJA:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136985694(Epac)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

106458479 106466050 106473199

PMEO:

129586911

CEL:	CELE_T20G5.5(epac-1)

CBR:	CBG_09801(Cbr-epac-1)

CRQ:	GCK72_009608

NAI:	NECAME_09247

BMY:	BM_BM5869(Bma-epac-1)

LOA:	LOAG_17670

TSP:

Tsp_01532

LGI:	LOTGIDRAFT_135052

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MCAF:

OBI:

OSN:

LJP:

LAK:	106158702 106181129

OVI:	T265_07226

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

TAD:	TRIADDRAFT_51758

AQU:

100638923

» show all

Reference

PMID:20055708

Authors

Gloerich M, Bos JL

Title

Epac: defining a new mechanism for cAMP action.

Journal

Annu Rev Pharmacol Toxicol 50:355-75 (2010)
DOI:10.1146/annurev.pharmtox.010909.105714

Reference

PMID:9856955

Authors

Kawasaki H, Springett GM, Mochizuki N, Toki S, Nakaya M, Matsuda M, Housman DE, Graybiel AM

Title

A family of cAMP-binding proteins that directly activate Rap1.

Journal

Science 282:2275-9 (1998)
DOI:10.1126/science.282.5397.2275

Sequence

[hsa:11069]

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   KEGG MGENES (347)   
   RefGene (544)   
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Literature (2)   
   PubMed (2)   
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