KEGG ORTHOLOGY: K04357

ORTHOLOGY: K04357

Entry

K04357                      KO

Symbol

EGF

Name

epidermal growth factor

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map04010

MAPK signaling pathway

map04012

ErbB signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04020

Calcium signaling pathway

map04066

HIF-1 signaling pathway

map04068

FoxO signaling pathway

map04072

Phospholipase D signaling pathway

map04151

PI3K-Akt signaling pathway

map04510

Focal adhesion

map04518

Integrin signaling

map04540

Gap junction

map04630

JAK-STAT signaling pathway

map04810

Regulation of actin cytoskeleton

map05160

Hepatitis C

map05165

Human papillomavirus infection

map05200

Pathways in cancer

map05207

Chemical carcinogenesis - receptor activation

map05208

Chemical carcinogenesis - reactive oxygen species

map05210

Colorectal cancer

map05212

Pancreatic cancer

map05213

Endometrial cancer

map05214

Glioma

map05215

Prostate cancer

map05218

Melanoma

map05219

Bladder cancer

map05223

Non-small cell lung cancer

map05224

Breast cancer

map05226

Gastric cancer

map05231

Choline metabolism in cancer

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

Disease

H00020

Colorectal cancer

H01210

Hypomagnesemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04357  EGF; epidermal growth factor
   04012 ErbB signaling pathway
    K04357  EGF; epidermal growth factor
   04014 Ras signaling pathway
    K04357  EGF; epidermal growth factor
   04015 Rap1 signaling pathway
    K04357  EGF; epidermal growth factor
   04630 JAK-STAT signaling pathway
    K04357  EGF; epidermal growth factor
   04066 HIF-1 signaling pathway
    K04357  EGF; epidermal growth factor
   04068 FoxO signaling pathway
    K04357  EGF; epidermal growth factor
   04020 Calcium signaling pathway
    K04357  EGF; epidermal growth factor
   04072 Phospholipase D signaling pathway
    K04357  EGF; epidermal growth factor
   04151 PI3K-Akt signaling pathway
    K04357  EGF; epidermal growth factor
  09133 Signaling molecules and interaction
   04518 Integrin signaling
    K04357  EGF; epidermal growth factor
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04357  EGF; epidermal growth factor
   04540 Gap junction
    K04357  EGF; epidermal growth factor
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04357  EGF; epidermal growth factor
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04357  EGF; epidermal growth factor
   05207 Chemical carcinogenesis - receptor activation
    K04357  EGF; epidermal growth factor
   05208 Chemical carcinogenesis - reactive oxygen species
    K04357  EGF; epidermal growth factor
   05231 Choline metabolism in cancer
    K04357  EGF; epidermal growth factor
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04357  EGF; epidermal growth factor
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04357  EGF; epidermal growth factor
   05212 Pancreatic cancer
    K04357  EGF; epidermal growth factor
   05226 Gastric cancer
    K04357  EGF; epidermal growth factor
   05214 Glioma
    K04357  EGF; epidermal growth factor
   05218 Melanoma
    K04357  EGF; epidermal growth factor
   05219 Bladder cancer
    K04357  EGF; epidermal growth factor
   05215 Prostate cancer
    K04357  EGF; epidermal growth factor
   05213 Endometrial cancer
    K04357  EGF; epidermal growth factor
   05224 Breast cancer
    K04357  EGF; epidermal growth factor
   05223 Non-small cell lung cancer
    K04357  EGF; epidermal growth factor
  09172 Infectious disease: viral
   05160 Hepatitis C
    K04357  EGF; epidermal growth factor
   05165 Human papillomavirus infection
    K04357  EGF; epidermal growth factor
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04357  EGF; epidermal growth factor
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K04357  EGF; epidermal growth factor
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Growth factors (RTK binding)
   K04357  EGF; epidermal growth factor

Other DBs

GO:

0005155

Genes

HSA:

1950(EGF)

PTR:	461435(EGF)

PPS:	100975632(EGF)

GGO:	101153700(EGF)

PON:	100455021(EGF)

PPYG:

129035589(EGF)

NLE:	100588963(EGF)

HMH:	116479721(EGF)

SSYN:

129480246(EGF)

MCC:	698619(EGF)

MCF:	102123415(EGF)

MTHB:

126954925

MNI:	105486254(EGF)

CSAB:

103236114(EGF)

CATY:

105571434(EGF)

PANU:

101026665(EGF)

TGE:	112624610(EGF)

MLEU:

105532399(EGF)

RRO:	104682421(EGF)

RBB:	108541026(EGF)

TFN:	117085785(EGF)

PTEH:

111547933(EGF)

CANG:

105514419(EGF)

CJC:	100388651(EGF)

SBQ:	101052478(EGF)

CIMI:

108290027(EGF)

ANAN:

105706249(EGF)

CSYR:

103267942(EGF)

MMUR:

105872305(EGF)

LCAT:

123627755(EGF)

ERUF:

138375527(EGF)

PCOQ:

105818935(EGF)

OGA:	100959686(EGF)

MMU:	13645(Egf)

MCAL:

110291005(Egf)

MPAH:

110320006(Egf)

RNO:	25313(Egf)

MCOC:

116093773(Egf)

ANU:	117707556(Egf)

ASYL:

127682699(Egf)

MUN:	110553196(Egf)

CGE:	100763146(Egf)

MAUA:

101830366(Egf)

PROB:

127223042(Egf)

PLEU:

114682692(Egf)

PMAV:

102910497(Egf)

MORG:

121466544(Egf)

MFOT:

126509286

AAMP:

119800992(Egf)

CNL:	130889359(Egf)

NGI:	103742642(Egf)

HGL:	106007527(Egf)

CPOC:

100714471(Egf)

CCAN:

109700925(Egf)

DORD:

105991200(Egf)

DSP:	122127051(Egf)

DMER:

138826992(Egf)

PLOP:

125341585(Egf)

NCAR:

124994951

SVUL:

306669542(EGF)

MMMA:

107141390(Egf)

ITI:	101973163(Egf)

OCU:

100008808

OPI:	101536206(EGF)

OCZ:	121147500(EGF)

TUP:	102490423(EGF)

GVR:	103588497(EGF)

CFA:	403657(EGF)

CLUD:

112671646(EGF)

VVP:	112934223(EGF)

VLG:	121492863(EGF)

NPO:	129521218(EGF)

AML:

100467733

UMR:	103661742(EGF)

UAH:	113255562(EGF)

UAR:	123793362(EGF)

ELK:

111156359

LLV:

125093282

MPUF:

101682951(EGF)

MNP:	132002212(EGF)

MLK:	131829316(EGF)

NVS:	122889261(EGF)

MMAQ:

308338689(EGF)

ORO:	101377629(EGF)

EJU:	114222658(EGF)

ZCA:	113925832(EGF)

MLX:	118027092(EGF)

MANO:

123848320(EGF)

NSU:	110575510(EGF)

LWW:	102742915(EGF)

FCA:	493978(EGF)

PYU:	121031012(EGF)

PCOO:

112858016(EGF)

PBG:	122477450(EGF)

PVIV:

125164093(EGF)

LRUF:

124520329

LGF:	123593848(EGF)

AJU:

106983657

PTG:	102959656(EGF)

PPAD:

109248153(EGF)

PUC:

125923024

PLEZ:

122217951(EGF)

HHV:	120236138(EGF)

CCRU:

144243413(EGF)

BTA:	530315(EGF)

BOM:	102285914(EGF)

BIU:	109559983(EGF)

BJV:	133249260(EGF)

BBUB:

102416325(EGF)

BKE:	129657394(EGF)

BBIS:

105002073(EGF)

CHX:	106502173(EGF)

BTAX:

128050008(EGF)

ODA:	120862277(EGF)

CCAD:

122422171(EGF)

MREE:

136147868(EGF)

OVR:	110133756(EGF)

MBEZ:

129561712(EGF)

SSC:	397083(EGF)

CFR:	102523769(EGF)

CBAI:

105067960(EGF)

CDK:	105089905(EGF)

VPC:	102537002(EGF)

BACU:

103004366(EGF)

BMUS:

118895543(EGF)

LVE:	103073883(EGF)

OOR:	101283152(EGF)

LALB:

132519463(EGF)

GMF:	115857342(EGF)

DDP:	132426110(EGF)

SCOO:

307186107(EGF)

PCRS:

137223492(EGF)

DLE:	111186135(EGF)

PCAD:

102977431(EGF)

PSIU:

116754608(EGF)

PPHC:

136123312(EGF)

NASI:

112397683(EGF)

HAMP:

307055448(EGF)

ECB:	106782874(EGF)

EPZ:	103543333(EGF)

EAI:	106829795(EGF)

MYB:	102264252(EGF)

MYD:	102758044(EGF)

MMYO:

118672981(EGF)

MLF:	102424256(EGF)

MDT:	132214841(EGF)

MYUM:

138992192(EGF)

PKL:	118702736(EGF)

EFUS:

114234667(EGF)

POTS:

308255434(EGF)

MNA:	107534373(EGF)

DRO:	112296254(EGF)

SHON:

118977074(EGF)

AJM:	119057431(EGF)

PDIC:

114492590(EGF)

PHAS:

123806865(EGF)

MMF:	118634494(EGF)

PPAM:

129085287(EGF)

HAI:	109379436(EGF)

RFQ:	117021897(EGF)

RHII:

308504200(EGF)

PALE:

102891552(EGF)

PGIG:

120591156(EGF)

PVP:	105293045(EGF)

RAY:	107508819(EGF)

MJV:	108408073(EGF)

TOD:	119243624(EGF)

SARA:

101541792(EGF)

SFUM:

130025976(EGF)

SETR:

126027570(EGF)

LAV:	100670137(EGF)

TMU:

101355971

ETF:	101645300(EGF)

DNM:	101418748(EGF)

MDO:	100619143(EGF)

GAS:	123253141(EGF)

SHR:	100933169(EGF)

AFZ:

127540419

PCW:	110218605(EGF)

TVP:	118854108(EGF)

PBRV:

138170775(EGF)

MLAO:

141517562(EGF)

OAA:	100074960(EGF)

TACU:

119935692(EGF)

GGA:	408035(EGF)

PCOC:

116231267(EGF)

MGP:	100543460(EGF)

CJO:	107313609(EGF)

TPAI:

128080350(EGF)

LMUT:

125692196(EGF)

NMEL:

110399042(EGF)

APLA:

101795002(EGF)

AACU:

137856513(EGF)

OJA:	118166018(EGF)

BCLA:

308442839(EGF)

ACYG:

106038683(EGF)

ABRC:

308195154(EGF)

CATA:

118254590(EGF)

AFUL:

116488496(EGF)

TGU:	100218747(EGF)

LSR:	110467994(EGF)

VMC:	128806894(EGF)

VCHA:

128787593(EGF)

AIB:	137472357(EGF)

SCAN:

103826255(EGF)

PMOA:

120502809(EGF)

OTC:	121331417(EGF)

PRUF:

121360365(EGF)

ATRC:

139592209(EGF)

MATE:

118686040(EGF)

MAEN:

136555448(EGF)

GFR:	102034269(EGF)

FAB:	101819290(EGF)

OMA:	130252816(EGF)

PHI:	102112980(EGF)

PMAJ:

107203603(EGF)

CCAE:

111927782(EGF)

CCW:	104697130(EGF)

CBRC:

103617399(EGF)

ACOE:

138109628(EGF)

ETL:	114062174(EGF)

ZAB:	102065155(EGF)

ZLE:	135446736(EGF)

ACHL:

103797310 103800957

SVG:	106854429(EGF)

MMEA:

130576234(EGF)

HRT:	120753452(EGF)

SATI:

136360503(EGF)

CFAI:

136291294(EGF)

CCIC:

134044522(EGF)

SHAB:

115610465(EGF)

POCC:

134172989(EGF)

FPG:	101916879(EGF)

FCH:	102049265(EGF)

FRS:	119145054(EGF)

CCRI:

104161084

ACUN:

113479739(EGF)

ANOC:

141960271(EGF)

SURA:

141942860(EGF)

TALA:

104364351(EGF)

ACHC:

115344703(EGF)

HALD:

104321638(EGF)

HLE:	104843353(EGF)

AGEN:

126044935

HHAR:

128135553(EGF)

BBUT:

142033157(EGF)

GCL:

127015786

CSTI:

104558875(EGF)

LDI:	104343767(EGF)

MNB:	103772713(EGF)

DPUB:

104304147(EGF)

PPUS:

135178041(EGF)

IIN:	128968558(EGF)

AVIT:

104274119(EGF)

BRHI:

104499298(EGF)

EGZ:	104135535(EGF)

NNI:	104021157(EGF)

PCRI:

104033554(EGF)

PCAO:

104043574(EGF)

PARX:

142056210(EGF)

PADL:

103926035(EGF)

AFOR:

103894243(EGF)

FGA:	104075495(EGF)

CBOR:

142082485(EGF)

GSTE:

104254810(EGF)

CBOY:

140651818(EGF)

MAME:

142409346(EGF)

CLV:	102083886(EGF)

CNIC:

135988748(EGF)

NMAY:

308040288(EGF)

MUI:	104538737(EGF)

PGUU:

104471930

EHS:	104516802(EGF)

CMAC:

104484067(EGF)

CUCA:

104062856(EGF)

PCUR:

138719911(EGF)

TEO:	104375183(EGF)

BREG:

104633850(EGF)

GAME:

129206413(EGF)

OHA:	104327240(EGF)

ACAR:

104532081

CEUR:

306717915(EGF)

CPEA:

104394485(EGF)

CVF:	104286838(EGF)

RTD:	128910553(EGF)

CRID:

134516460(EGF)

LMIC:

141744079(EGF)

NARQ:

141464678(EGF)

AAM:	106491937(EGF)

AROW:

112972475(EGF)

NPD:	112957256(EGF)

TGT:	104580798(EGF)

DNE:	112984130(EGF)

SCAM:

104138015(EGF)

ASN:	102388605(EGF)

AMJ:	102560233(EGF)

CPOO:

109309386(EGF)

GGN:	109301074(EGF)

PSS:	102453328(EGF)

CIZ:	142012719(EGF)

CMY:	102933086(EGF)

CCAY:

125635272(EGF)

LKP:	140910308(EGF)

NDS:	141986342(EGF)

DCC:	119855290(EGF)

CPIC:

101934754(EGF)

TST:	117877887(EGF)

CABI:

116827248(EGF)

MRV:	120407021(EGF)

EMQ:	137166463(EGF)

ACS:	100562822(egf)

ASAO:

132776917(EGF)

PVT:	110087292(EGF)

SUND:

121931923(EGF)

PBI:	103061516(EGF)

PMUR:

107290128(EGF)

CTIG:

120305920(EGF)

TSR:	106554022 106555130

PGUT:

117679942(EGF)

PCAE:

139320260(EGF)

APRI:

131203443(EGF)

PTEX:

113434620(EGF)

NSS:	113412783(EGF)

VKO:	123022650(EGF)

PMUA:

114604055(EGF)

PRAF:

128421254(EGF)

ZVI:	118083713(EGF)

HCG:	128327743(EGF)

GJA:	107122699(EGF)

STOW:

125439707(EGF)

EMC:	129336966(EGF)

XLA:	108710179(egf.L)

XTR:	100127663(egf)

NPR:	108798307(EGF)

RTEM:

120917738(EGF)

ACAT:

141110782(EGF)

PADS:

140326799(EGF)

BBUF:

120989919(EGF)

BGAR:

122946843(EGF)

DTC:	141086159(EGF)

PWL:	138290466(EGF)

MUO:	115461197(EGF)

GSH:	117365240(EGF)

DRE:	403045(egf)

DAES:

130240587(egf)

SRX:	107723791 107740113

SANH:

107662948 107669104

SGH:	107569836 107602591

CCAR:

109088262(egf)

CAUA:

113114148

CGIB:

127971069

PTET:

122357370(egf)

LROH:

127175864(egf)

GRF:	141288519(egf)

OMC:	131552902(egf)

PPRM:

120474329(egf)

RKG:	130095158(egf)

MAMB:

125259410(egf)

CIDE:

127494859

CERY:

137015259(egf)

MASI:

127412934 127418317

TROS:

130563551(egf)

TDW:	130438198(egf)

MANU:

129422811(egf)

PDAB:

135757932(egf)

IPU:

108268549

IFU:	128612081(egf)

PHYP:

113547167

SMEO:

124386114(egf)

TFD:	113648177(egf)

TVC:	132855618(egf)

CGAR:

128531887(egf)

NGRA:

132890319(egf)

TRN:	134319685(egf)

CMAO:

118806475(egf)

EEE:	113579942(egf)

CHAR:

105906165(egf)

SPIL:

134096174(egf)

ASAD:

121681999(egf)

TRU:	101061284(egf)

TFS:	130530828(egf)

TNG:	GSTEN00024402G001

NCC:	104953729(egf)

TBEN:

117491568(egf)

CGOB:

115014303(egf)

PGEO:

117453993(egf)

GACU:

117553610(egf)

EMAC:

134859778(egf)

ELY:	117260540(egf)

EFO:	125894020(egf)

PLEP:

121947780(egf)

SLUC:

116052916(egf)

ECRA:

117951707(egf)

ESP:	116696510(egf)

PFLV:

114563345(egf)

GAT:	120818259(egf)

PPUG:

119211628(egf)

AFB:	129090086(egf)

CLUM:

117737231(egf)

PSWI:

130209810(egf)

CANA:

137794695(egf)

MSAM:

119888559(egf)

SCHU:

122880618(egf)

EARM:

139291464(egf)

CUD:	121516668(egf)

SPUL:

138598472(egf)

LMIX:

132981617(egf)

HTC:	141793171(egf)

ALAT:

119008156(egf)

ASTR:

137603017(egf)

PKLU:

139207445(egf)

LCO:	104917921(egf)

MZE:	101487082(egf)

ONL:	100706539(egf)

OAU:	116335758(egf)

OLA:	101167023(egf)

OML:	112141457(egf)

CSAI:

133447340(egf)

XMA:	102219388(egf)

XCO:	114138665(egf)

XHE:	116714467(egf)

PRET:

103471828(egf)

PFOR:

103137346(egf)

PLAI:

106960087(egf)

PMEI:

106929540(egf)

GAF:	122837113(egf)

PPRL:

129360254 129360259

CVG:	107095811(egf)

CTUL:

119772614(egf)

GMU:	124860567(egf)

NFU:	107374766(egf)

KMR:	108236662(egf)

ALIM:

106513245

NWH:	119408618(egf)

LTU:	140318505(egf)

MCEP:

125008212(egf)

AOCE:

111588376(egf)

EJA:	138211321(egf)

BFRE:

138622747(egf)

LCF:

108885177

CSEM:

103390644(egf)

POV:	109625474(egf)

SSEN:

122778301(egf)

SSOE:

131473070(egf)

HHIP:

117769534(egf)

HSP:	118111983(egf)

PPLT:

128446238(egf)

SMAU:

118319905(egf)

SDU:	111232468(egf)

SLAL:

111648180(egf)

XGL:	120785682(egf)

HCQ:	109524192(egf)

SSCV:

125986952(egf)

SBIA:

133508301(egf)

PEE:	133407368(egf)

PTAO:

133485125(egf)

BPEC:

110153711(egf)

ENY:	140349006(egf)

MALB:

109964289

BSPL:

114864025(egf)

SJO:	128362833(egf)

SSCO:

133986389(egf)

TTY:	137188701(egf)

GMH:

115552898

SASA:

106611584(egf)

STRU:

115205115

OTW:	112256330(egf)

OMY:	110505117(egf)

OGO:	124011368(egf)

ONE:	115129161(egf)

OKI:

109904732

OKE:	118363115(egf)

OMM:	135545214(egf)

OCLA:

139390984

SALP:

111968192(egf)

SNH:

120061877

SFON:

129827963

CCLU:

121537076(egf)

ELS:	105027559(egf)

OEP:	134032922(egf)

SFM:	108938717(egf)

PKI:	111849374(egf)

LOC:	102689722(egf)

PSPA:

121295627 121322456

ARUT:

117408408 117421414

PSEX:

120533101(egf)

LCM:	102348800 102356822(EGF)

CMK:	103180890(egf)

RTP:	109929559(egf)

CPLA:

122553658(egf)

CPUN:

140483636(egf)

HOC:	132816749(egf)

SCAU:

119963291(egf)

LERI:

129703176(egf)

HAKA:

140726535(egf)

SKO:

102807105

HRO:	HELRODRAFT_189631

HRF:

124145077

ADF:

107331023

» show all

Reference

PMID:3491360

Authors

Bell GI, Fong NM, Stempien MM, Wormsted MA, Caput D, Ku LL, Urdea MS, Rall LB, Sanchez-Pescador R

Title

Human epidermal growth factor precursor: cDNA sequence, expression in vitro and gene organization.

Journal

Nucleic Acids Res 14:8427-46 (1986)
DOI:10.1093/nar/14.21.8427

Sequence

[hsa:1950]

Reference

PMID:10964941

Authors

Hermann PM, van Kesteren RE, Wildering WC, Painter SD, Reno JM, Smith JS, Kumar SB, Geraerts WP, Ericsson LH, Smit AB, Bulloch AG, Nagle GT

Title

Neurotrophic actions of a novel molluscan epidermal growth factor.

Journal

J Neurosci 20:6355-64 (2000)
DOI:10.1523/JNEUROSCI.20-17-06355.2000

Sequence

[mmu:13645]

All links

Ontology (1)   
   GO (1)   
Gene (335)   
   MGENES (178)   
   RefGene (152)   
   OC (5)   
All databases (336)   

Download RDF

ORTHOLOGY: K04359

Entry

K04359                      KO

Symbol

PDGFA

Name

platelet-derived growth factor subunit A

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04020

Calcium signaling pathway

map04072

Phospholipase D signaling pathway

map04151

PI3K-Akt signaling pathway

map04510

Focal adhesion

map04518

Integrin signaling

map04540

Gap junction

map04630

JAK-STAT signaling pathway

map04810

Regulation of actin cytoskeleton

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05206

MicroRNAs in cancer

map05214

Glioma

map05215

Prostate cancer

map05218

Melanoma

map05231

Choline metabolism in cancer

map05418

Fluid shear stress and atherosclerosis

Disease

H00015

Malignant pleural mesothelioma

H00042

Glioma

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04014 Ras signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04015 Rap1 signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04630 JAK-STAT signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04020 Calcium signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04072 Phospholipase D signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04151 PI3K-Akt signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
  09133 Signaling molecules and interaction
   04518 Integrin signaling
    K04359  PDGFA; platelet-derived growth factor subunit A
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04359  PDGFA; platelet-derived growth factor subunit A
   04540 Gap junction
    K04359  PDGFA; platelet-derived growth factor subunit A
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04359  PDGFA; platelet-derived growth factor subunit A
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05202 Transcriptional misregulation in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05206 MicroRNAs in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05231 Choline metabolism in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
  09162 Cancer: specific types
   05214 Glioma
    K04359  PDGFA; platelet-derived growth factor subunit A
   05218 Melanoma
    K04359  PDGFA; platelet-derived growth factor subunit A
   05215 Prostate cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04359  PDGFA; platelet-derived growth factor subunit A
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04359  PDGFA; platelet-derived growth factor subunit A
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K04359  PDGFA; platelet-derived growth factor subunit A
   00536 Glycosaminoglycan binding proteins
    K04359  PDGFA; platelet-derived growth factor subunit A
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Growth factors (RTK binding)
   K04359  PDGFA; platelet-derived growth factor subunit A
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Growth factors/receptors
   K04359  PDGFA; platelet-derived growth factor subunit A

Other DBs

GO:

0005161

Genes

HSA:	5154(PDGFA)

PTR:	740202(PDGFA)

PPS:	100991389(PDGFA)

GGO:	101132059(PDGFA)

PON:	100440212(PDGFA)

PPYG:

129040960(PDGFA)

NLE:	100583683(PDGFA)

HMH:	116462932(PDGFA)

SSYN:

129471850(PDGFA)

MCC:	707725(PDGFA)

MCF:	102126620(PDGFA)

MTHB:

126950578

MNI:	105483431(PDGFA)

CSAB:

103246906(PDGFA)

CATY:

105571784(PDGFA)

PANU:

100998521(PDGFA)

TGE:	112620011(PDGFA)

MLEU:

105537884(PDGFA)

RRO:	104664975(PDGFA)

RBB:	108542315(PDGFA)

TFN:	117072614(PDGFA)

PTEH:

111523727(PDGFA)

CANG:

105522469(PDGFA)

CJC:	100412906(PDGFA)

SBQ:	101034511(PDGFA)

CIMI:

108289011(PDGFA)

ANAN:

135275177(PDGFA)

CSYR:

103255351(PDGFA)

MMUR:

105868355(PDGFA)

LCAT:

123632534(PDGFA)

ERUF:

138394180(PDGFA)

PCOQ:

105806045(PDGFA)

OGA:	100944643(PDGFA)

MMU:	18590(Pdgfa)

MCAL:

110294651(Pdgfa)

MPAH:

110312881(Pdgfa)

RNO:	25266(Pdgfa)

MCOC:

116068639(Pdgfa)

ANU:	143438011(Pdgfa)

ASYL:

127672774(Pdgfa)

MUN:	110550699(Pdgfa)

CGE:	100771503(Pdgfa)

MAUA:

101832477(Pdgfa)

PROB:

127237325(Pdgfa)

PLEU:

114682214(Pdgfa)

PMAV:

102908814(Pdgfa)

MORG:

121446311(Pdgfa)

MFOT:

126514366

AAMP:

119825753(Pdgfa)

NGI:	103748699(Pdgfa)

HGL:	101725739(Pdgfa)

CCAN:

109684500(Pdgfa)

DORD:

105990925(Pdgfa)

DSP:	122113621(Pdgfa)

DMER:

138834722(Pdgfa)

PLOP:

125339510(Pdgfa)

NCAR:

124970285

MMMA:

107155905(Pdgfa)

ITI:	101963872(Pdgfa)

SCIL:

308651061(PDGFA)

MAVE:

308268274(PDGFA)

OCU:

100352388

OCZ:	121162743(PDGFA)

TUP:	102499235(PDGFA)

GVR:	103595105(PDGFA)

CFA:	491597(PDGFA)

CLUD:

112640154(PDGFA)

VVP:	112929281(PDGFA)

VLG:	121487555(PDGFA)

NPO:	129519919(PDGFA)

AML:	100473486(PDGFA)

UMR:	103670054(PDGFA)

UAR:	123802515(PDGFA)

ELK:

111145884

LLV:

125090848

MPUF:

101684232(PDGFA)

MNP:	132026405(PDGFA)

MLK:	131819467(PDGFA)

NVS:	122895287(PDGFA)

MMAQ:

308359585(PDGFA)

ORO:	101386160(PDGFA)

ZCA:	113933137(PDGFA)

MLX:	117999262(PDGFA)

MANO:

123844948(PDGFA)

NSU:	110571958(PDGFA)

LWW:	102739254(PDGFA)

FCA:	101087287(PDGFA)

PYU:	121017467(PDGFA)

PBG:	122471191(PDGFA)

PVIV:

125154510(PDGFA)

LRUF:

124519341

LGF:	123588792(PDGFA)

AJU:

106966514

PPAD:

109251089(PDGFA)

PUC:

125928362

PLEZ:

122210061(PDGFA)

HHV:	120227991(PDGFA)

CCRU:

144227210(PDGFA)

BTA:	505908(PDGFA)

BOM:	102271219(PDGFA)

BIU:	109578611(PDGFA)

BJV:	133238844(PDGFA)

BKE:	129637453(PDGFA)

BBIS:

104987448(PDGFA)

CHX:	102174268(PDGFA)

OAS:	114110564(PDGFA)

OCAN:

138429620(PDGFA)

BTAX:

128065733(PDGFA)

CSUM:

138076081(PDGFA)

ODA:	120882986(PDGFA)

CCAD:

122433132(PDGFA)

MREE:

136160241(PDGFA)

OVR:	110130402(PDGFA)

MBEZ:

129545815(PDGFA)

SSC:	100519764(PDGFA)

CFR:	102520052(PDGFA)

CBAI:

105077813(PDGFA)

CDK:	105102061(PDGFA)

VPC:	102532201(PDGFA)

BACU:

103005337(PDGFA)

BMUS:

118881469(PDGFA)

LVE:	103089216(PDGFA)

OOR:	101287211(PDGFA)

LALB:

132505226(PDGFA)

GMF:	115849594(PDGFA)

DDP:	132438917(PDGFA)

SCOO:

307198718(PDGFA)

DLE:	111169371(PDGFA)

PCAD:

102989848(PDGFA)

PSIU:

116740378(PDGFA)

PPHC:

136134750(PDGFA)

NASI:

112412068(PDGFA)

HAMP:

307062842(PDGFA)

ECB:	100055086(PDGFA)

EPZ:	103555992(PDGFA)

EAI:	106834748(PDGFA)

MYB:	102253551(PDGFA)

MYD:	102762551(PDGFA)

MMYO:

118658213(PDGFA)

MLF:	102422469(PDGFA)

MDT:	132236071(PDGFA)

MYUM:

139010130(PDGFA)

PKL:	118715966(PDGFA)

EFUS:

103299170(PDGFA)

POTS:

308249893(PDGFA)

MNA:	107543141(PDGFA)

DRO:	112319719(PDGFA)

SHON:

118995064(PDGFA)

AJM:	119043762(PDGFA)

PDIC:

114510403(PDGFA)

PHAS:

123810721(PDGFA)

MMF:	118615652(PDGFA)

PPAM:

129065324(PDGFA)

HAI:	109380137(PDGFA)

RFQ:	117016876(PDGFA)

PALE:

102893670(PDGFA)

PGIG:

120615920(PDGFA)

PVP:	105294593(PDGFA)

RAY:	107497394(PDGFA)

MJV:	118970652(PDGFA)

TOD:	119241452(PDGFA)

SARA:

101545086(PDGFA)

SFUM:

130036457(PDGFA)

SETR:

126030482(PDGFA)

TMU:

101344666

ETF:	101657212(PDGFA)

DNM:	101420455(PDGFA)

MDO:	100020951(PDGFA)

GAS:	123234190(PDGFA)

SHR:	100924985(PDGFA) 116422035

AFZ:

127564197

PCW:	110201572(PDGFA)

TVP:	118834675(PDGFA)

PBRV:

138158718(PDGFA)

MLAO:

141502628(PDGFA)

OAA:	100081033(PDGFA)

TACU:

119942594(PDGFA)

GGA:	374196(PDGFA)

PCOC:

116237353(PDGFA)

MGP:	100545955(PDGFA)

CJO:	107320713(PDGFA)

TPAI:

128079041(PDGFA)

LMUT:

125700597(PDGFA)

NMEL:

110405632(PDGFA)

APLA:

101803502(PDGFA)

AACU:

137865168(PDGFA)

BCLA:

308449548(PDGFA)

ACYG:

106033384(PDGFA)

ABRC:

308178031(PDGFA)

CATA:

118249111(PDGFA)

AFUL:

116495257(PDGFA)

TGU:	100222155(PDGFA)

LSR:	110475507(PDGFA)

VMC:	128815462(PDGFA)

VCHA:

128796288(PDGFA)

AIB:	137483718(PDGFA)

SCAN:

103817870(PDGFA)

PMOA:

120513085(PDGFA)

OTC:	121334533(PDGFA)

PRUF:

121350738(PDGFA)

ATRC:

139598085(PDGFA)

MATE:

118692367(PDGFA)

MAEN:

136563302(PDGFA)

GFR:	102032936(PDGFA)

FAB:	101810376(PDGFA)

OMA:	130259168(PDGFA)

PHI:	102099148(PDGFA)

PMAJ:

107211209(PDGFA)

CCAE:

111936274(PDGFA)

CCW:	104685042(PDGFA)

CBRC:

103615596(PDGFA)

ACOE:

138118912(PDGFA)

ETL:	114054750(PDGFA)

ZAB:	102075181(PDGFA)

ZLE:	135454389(PDGFA)

ACHL:

103808525(PDGFA)

SVG:	106849274(PDGFA)

MMEA:

130583111(PDGFA)

HRT:	120759459(PDGFA)

SATI:

136367877(PDGFA)

CFAI:

136298090(PDGFA)

CCIC:

134050589(PDGFA)

NNT:	104401729(PDGFA)

SHAB:

115606513(PDGFA)

POCC:

134158240(PDGFA)

FPG:	101922505(PDGFA)

FCH:	102059520(PDGFA)

FRS:	119147418(PDGFA)

CCRI:

104163324(PDGFA)

ACUN:

113485656(PDGFA)

ANOC:

141966323(PDGFA)

SURA:

141950834(PDGFA)

TALA:

104356513(PDGFA)

ACHC:

115335808(PDGFA)

HALD:

104311822(PDGFA)

HLE:	104833534(PDGFA)

AGEN:

126034072

HHAR:

128134821(PDGFA)

BBUT:

142045394(PDGFA)

GCL:

127022335

CSTI:

104550608(PDGFA)

LDI:	104341533(PDGFA)

MNB:	103772210(PDGFA)

DPUB:

104307709(PDGFA)

PPUS:

135180893(PDGFA)

IIN:	128974526(PDGFA)

AVIT:

104269103(PDGFA)

BRHI:

104499817

EGZ:	104128975(PDGFA)

NNI:	104015206(PDGFA)

PCRI:

104025397(PDGFA)

PCAO:

104048151

PARX:

142062510(PDGFA)

PADL:

103913559(PDGFA)

AFOR:

103904978(PDGFA)

FGA:	104071632(PDGFA)

CBOR:

142089146(PDGFA)

GSTE:

104251875(PDGFA)

CBOY:

140658856(PDGFA)

MAME:

142416300(PDGFA)

CLV:	102085857(PDGFA)

CNIC:

135994146(PDGFA)

NMAY:

308046413(PDGFA)

MUI:	104548409(PDGFA)

PGUU:

104463181(PDGFA)

PLET:

104615870(PDGFA)

EHS:	104515753(PDGFA)

CMAC:

104477662

CUCA:

104066003(PDGFA)

PCUR:

138727730(PDGFA)

TEO:	104373725(PDGFA)

BREG:

104631307(PDGFA)

GAME:

129213265(PDGFA)

OHA:	104329111(PDGFA)

ACAR:

104521094(PDGFA)

CEUR:

306725655(PDGFA)

CPEA:

104393744(PDGFA)

CVF:	104287451(PDGFA)

RTD:	128913970(PDGFA)

CRID:

134519278(PDGFA)

LMIC:

141747163(PDGFA)

NARQ:

141471741(PDGFA)

AROW:

112974232(PDGFA)

NPD:	112959759(PDGFA)

TGT:	104577799(PDGFA)

DNE:	112992914(PDGFA)

SCAM:

104153975(PDGFA)

ASN:	102386051(PDGFA)

AMJ:	102568490(PDGFA)

CPOO:

109314821(PDGFA)

GGN:	109294307(PDGFA)

PSS:	102453111(PDGFA)

CIZ:	142021426(PDGFA)

CMY:	102936738(PDGFA)

CCAY:

125643930(PDGFA)

LKP:	140918217(PDGFA)

NDS:	141994833(PDGFA)

DCC:	119863047(PDGFA)

CPIC:

101940087(PDGFA)

TST:	117883612(PDGFA)

EOB:	135884932(PDGFA)

CABI:

116819340(PDGFA)

MRV:	120373866(PDGFA)

EMQ:	137155009(PDGFA)

ACS:	100560004(pdgfa)

ASAO:

132780030(PDGFA)

PVT:	110090337(PDGFA)

SUND:

121914929(PDGFA)

PBI:	103066198(PDGFA)

PMUR:

107291891(PDGFA)

CTIG:

120315695(PDGFA)

PGUT:

117673284(PDGFA)

PCAE:

139325464(PDGFA)

APRI:

131185124(PDGFA)

PTEX:

113438773(PDGFA)

NSS:	113423617(PDGFA)

VKO:	123025095(PDGFA)

PMUA:

114584301(PDGFA)

PRAF:

128401314(PDGFA)

ZVI:	118092483(PDGFA)

HCG:	128336685(PDGFA)

GJA:	107115509(PDGFA)

STOW:

125431785(PDGFA)

EMC:	129340503(PDGFA)

XLA:	108701573(pdgfa.L) 397765(pdgfa.S)

XTR:	100038202(pdgfa)

NPR:	108800714(PDGFA)

RTEM:

120943462(PDGFA)

ACAT:

141148944(PDGFA)

PADS:

140335295(PDGFA)

BBUF:

121008336(PDGFA)

BGAR:

122938815(PDGFA)

DTC:	141047796(PDGFA)

HSQ:	130284940(PDGFA)

PCOB:

134945315(PDGFA)

PWL:	138261151(PDGFA)

MUO:	115475965(PDGFA)

GSH:	117345768(PDGFA)

DRE:	378480(pdgfaa) 767790(pdgfab) 796490(pdgfbb)

DAES:

130215902 130220874(pdgfab)

SRX:	107710051 107715705 107716439 107718638 107740670 107753752

SANH:

107653445 107655387 107656789 107659307 107661852 107662372

SGH:	107563229 107565186 107565608 107569132(pdgfa) 107582898 107585031

CCAR:

109046752 109046975 109060204(pdgfbb) 109077293(pdgfab) 109078395

CAUA:

113039942 113046740 113047958 113050994 113065132 113067655

CGIB:

127942589 127946206 127952842 127953549 127953918 127988409

PTET:

122328185 122341462(pdgfab) 122341906(pdgfbb)

LROH:

127153154(pdgfaa) 127162991(pdgfbb) 127163317(pdgfab)

GRF:	141324093(pdgfbb) 141339009(pdgfaa) 141344280(pdgfab)

OMC:	131530560(pdgfaa) 131536183(pdgfbb) 131538005(pdgfab)

PPRM:

120473118(pdgfab) 120489992(pdgfbb) 120495257

RKG:	130069207(pdgfab) 130101075(pdgfbb) 130103468

SCEP:

307155001(pdgfab) 307170153(pdgfaa)

MAMB:

125263758 125266909(pdgfab) 125273321(pdgfbb)

CIDE:

127508464 127509581 127520426

CERY:

137017385(pdgfbb) 137017882(pdgfab) 137029200(pdgfaa)

MASI:

127438286 127438857 127449997 127450278 127451399 127451886

TROS:

130548738 130562289(pdgfab) 130562299(pdgfbb)

TDW:	130425514(pdgfbb) 130426907(pdgfab) 130429407(pdgfaa)

MANU:

129436444(pdgfbb) 129436577 129453754(pdgfaa) 141348995

PDAB:

135733968(pdgfbb) 135734132(pdgfab) 135740996

IPU:	108259440 108260470(pdgfbb)

IFU:	128600808(pdgfbb) 128603042

PHYP:

113528535 113547595

SMEO:

124380081(pdgfaa) 124396930(pdgfbb)

TFD:	113638132(pdgfbb) 113657065

TVC:	132838686 132861009(pdgfbb)

CGAR:

128518548(pdgfaa) 128544744(pdgfbb)

NGRA:

132869295(pdgfbb) 132874908(pdgfaa)

TRN:

134304197

AMEX:

103022197 103031683(pdgfab) 103032641(pdgfbb)

CMAO:

118801273(pdgfab) 118804610

EEE:	113576794(pdgfa) 113581484

CHAR:

105897421 105905811 122133303

SPIL:

134076183 134076536

ASAD:

121705759(pdgfab) 121718448

TRU:	101063539 101077475(pdgfab)

TFS:	130515028(pdgfab) 130526903

TNG:	GSTEN00033366G001 GSTEN00034853G001

NCC:	104945697(pdgfa)

TBEN:

117484386 117492572(pdgfab)

CGOB:

115006184 115012768

PGEO:

117451375(pdgfab)

GACU:

117548665(pdgfab)

EMAC:

134862786 134878479(pdgfab)

ELY:	117255028(pdgfaa) 117268594(pdgfab)

EFO:	125879703(pdgfab) 125885505

PLEP:

121942499 121957233(pdgfab)

SLUC:

116042707 116059555(pdgfab)

SVIT:

144530147(pdgfab)

ECRA:

117957643(pdgfab) 117961247

ESP:	116700400 116703151(pdgfa)

PFLV:

114564713 114570050(pdgfa)

PFLT:

120568539 120574057(pdgfab)

GAT:	120828147(pdgfab)

PPUG:

119220851(pdgfab)

AFB:	129098582(pdgfab)

CLUM:

117735148(pdgfab)

PSWI:

130188983(pdgfab)

CANA:

137787198(pdgfab)

TBU:	306749372(pdgfab)

CVE:	137866661 137878319(pdgfab)

AMIR:

142937575(pdgfab)

MSAM:

119889692(pdgfab) 119898647

SCHU:

122868816(pdgfab) 122871829

EARM:

139292945 139300105(pdgfab)

CUD:	121503987(pdgfab) 121508825

SPUL:

138594958 138602710(pdgfab)

LMIX:

132954727(pdgfab) 132987377

HTC:	141787161 141809014(pdgfab)

ALAT:

119014493 119021530

ASTR:

137600216 137609935(pdgfab)

PKLU:

139199161 139216737(pdgfab)

LCO:	104925707(pdgfa) 104938193

AMMM:

307251356(pdgfaa) 307262438(pdgfab)

MZE:	101486813(pdgfab) 101486854(pdgfaa)

ONL:	100690958 100702821(pdgfa)

OAU:	116312442 116321448(pdgfab)

OLA:	101156252(pdgfa) 101171139

OML:	112137135 112147005(pdgfab)

CSAI:

133421623(pdgfab) 133452227

XMA:	102226782(pdgfa) 102233791

XCO:	114145269 114160156(pdgfa)

XHE:	116720596 116735865(pdgfa)

PRET:

103469195(pdgfab) 103476211

PFOR:

103141010(pdgfa) 103154828

PLAI:

106936519 106942707(pdgfa)

PMEI:

106904598 106915785(pdgfa)

GAF:	122822550(pdgfab) 122830142

PPRL:

129363603(pdgfab) 129367366

CVG:	107090056 107095213(pdgfa)

CTUL:

119773197(pdgfab) 119796294

GMU:	124863463 124863714 124867911

NFU:	107373888 107376493(pdgfa)

KMR:	108237947 108247650(pdgfab)

ALIM:

106518714(pdgfa) 106522509

NWH:	119420987(pdgfab) 119422948

LTU:	140273265(pdgfab) 140305705

MCEP:

124998222(pdgfab) 124999936

AOCE:

111562600(pdgfab) 111588207

EJA:	138198021(pdgfab) 138209600

BFRE:

138615798 138623344(pdgfab)

LCF:	108886167(pdgfab) 108887178

CSEM:

103383219 103393040

POV:	109638650(pdgfa) 109639258

SSEN:

122770440 122785574(pdgfab)

SSOE:

131466526 131475886(pdgfab)

HHIP:

117761949 117766492(pdgfab)

HSP:	118115566 118123505(pdgfab)

PPLT:

128436795 128459056(pdgfab)

SMAU:

118288941(pdgfab) 118312537

SDU:	111216525 111227111(pdgfa)

SLAL:

111667551(pdgfa) 111673426

XGL:	120788420(pdgfab) 120800741

HCQ:	109510962 109517731

SSCV:

125968948 125983657(pdgfab)

SBIA:

133505785 133515108(pdgfab)

PEE:	133404330 133415223(pdgfab)

PTAO:

133466036(pdgfab) 133477294

BPEC:

110169079(pdgfa)

ENY:	140358473(pdgfab)

MALB:

109952877 109972908(pdgfa)

BSPL:

114860735(pdgfab) 114862573

SJO:	128365180 128378975(pdgfab)

SSCO:

133986595 133999545(pdgfab)

TTY:	137180105 137200979(pdgfab)

GMH:	115540161(pdgfa)

SASA:

106564521 106564525 106590378 106601849 106606462

STRU:

115147415 115171767 115178656 115207403

OTW:	112236162 112241368

OMY:	100136119 110485559 110518436 118938428

OGO:	123999192 123999674 124016527

ONE:	115125364(pdgfa)

OKI:	109876032 116355530 116360001 116363050

OKE:	118382184 118382497 127931935

OMM:	135535021 135554657

OCLA:

139401892 139401894 139401976 139402056 139423766

SALP:

112074508 112075283

SNH:	120032526 120032527 120036319 120042520

SFON:

129833659 129835632

CCLU:

121551784 121551859 121553960

ELS:	105012099 105021652

OEP:

134016458

SFM:	108930223(pdgfa)

PKI:	111843309 111860586

AANG:

118219868

AROT:

135243511 135249275

CCOG:

133112543 133114725

LOC:	102685958(pdgfa)

PSPA:

121300937 121330521

ARUT:

117417838 117431157

PSEX:

120542103

LCM:	102352946(PDGFA)

CMK:	103175503 103178687

RTP:	109916423 109936774

CPLA:

CPUN:

HOC:

SCAU:

LERI:

HAKA:

PMRN:

116956877(PDGFA)

LRJ:	133347413(PDGFA)

BBEL:

BMOR:

BPHI:

AAGE:

OFU:

ONU:

ATRA:

GMW:

ECLR:

LGLY:

CSTB:

Reference

PMID:3422746

Authors

Bonthron DT, Morton CC, Orkin SH, Collins T

Title

Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing.

Journal

Proc Natl Acad Sci U S A 85:1492-6 (1988)
DOI:10.1073/pnas.85.5.1492

Sequence

[hsa:5154]

All links

Ontology (1)   
   GO (1)   
Gene (208)   
   MGENES (51)   
   RefGene (153)   
   OC (4)   
All databases (209)   

Download RDF

ORTHOLOGY: K04526

Entry

K04526                      KO

Symbol

INS

Name

insulin

Pathway

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04022

cGMP-PKG signaling pathway

map04066

HIF-1 signaling pathway

map04068

FoxO signaling pathway

map04072

Phospholipase D signaling pathway

map04081

Hormone signaling

map04114

Oocyte meiosis

map04140

Autophagy - animal

map04150

mTOR signaling pathway

map04151

PI3K-Akt signaling pathway

map04152

AMPK signaling pathway

map04211

Longevity regulating pathway

map04213

Longevity regulating pathway - multiple species

map04810

Regulation of actin cytoskeleton

map04910

Insulin signaling pathway

map04911

Insulin secretion

map04913

Ovarian steroidogenesis

map04914

Progesterone-mediated oocyte maturation

map04917

Prolactin signaling pathway

map04923

Regulation of lipolysis in adipocytes

map04930

Type II diabetes mellitus

map04931

Insulin resistance

map04932

Non-alcoholic fatty liver disease

map04940

Type I diabetes mellitus

map04950

Maturity onset diabetes of the young

map04960

Aldosterone-regulated sodium reabsorption

map05010

Alzheimer disease

map05215

Prostate cancer

map05415

Diabetic cardiomyopathy

Disease

H00408

Type 1 diabetes mellitus

H00410

Maturity onset diabetes of the young (MODY)

H00512

Permanent neonatal diabetes mellitus

H03052

Hyperproinsulinemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04526  INS; insulin
   04014 Ras signaling pathway
    K04526  INS; insulin
   04015 Rap1 signaling pathway
    K04526  INS; insulin
   04066 HIF-1 signaling pathway
    K04526  INS; insulin
   04068 FoxO signaling pathway
    K04526  INS; insulin
   04072 Phospholipase D signaling pathway
    K04526  INS; insulin
   04022 cGMP-PKG signaling pathway
    K04526  INS; insulin
   04151 PI3K-Akt signaling pathway
    K04526  INS; insulin
   04152 AMPK signaling pathway
    K04526  INS; insulin
   04150 mTOR signaling pathway
    K04526  INS; insulin
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    K04526  INS; insulin
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K04526  INS; insulin
  09143 Cell growth and death
   04114 Oocyte meiosis
    K04526  INS; insulin
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04526  INS; insulin
09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04526  INS; insulin
   04910 Insulin signaling pathway
    K04526  INS; insulin
   04923 Regulation of lipolysis in adipocytes
    K04526  INS; insulin
   04913 Ovarian steroidogenesis
    K04526  INS; insulin
   04914 Progesterone-mediated oocyte maturation
    K04526  INS; insulin
   04917 Prolactin signaling pathway
    K04526  INS; insulin
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K04526  INS; insulin
  09149 Aging
   04211 Longevity regulating pathway
    K04526  INS; insulin
   04213 Longevity regulating pathway - multiple species
    K04526  INS; insulin
09160 Human Diseases
  09162 Cancer: specific types
   05215 Prostate cancer
    K04526  INS; insulin
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04526  INS; insulin
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K04526  INS; insulin
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04526  INS; insulin
   04940 Type I diabetes mellitus
    K04526  INS; insulin
   04950 Maturity onset diabetes of the young
    K04526  INS; insulin
   04932 Non-alcoholic fatty liver disease
    K04526  INS; insulin
   04931 Insulin resistance
    K04526  INS; insulin
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K04526  INS; insulin
Cytokines and neuropeptides [BR:ko04052]
Neuropeptides
  Unclassified
   K04526  INS; insulin

Genes

HSA:

3630(INS)

PTR:	449570(INS)

PPS:	100969387(INS)

GGO:	101132604(INS)

PPYG:

129007934(INS)

NLE:	100586809(INS)

MCC:	704534(INS)

MCF:	102133184(INS)

MTHB:

126935873

MNI:	105469786(INS)

CSAB:

103239029(INS)

CATY:

105577261(INS)

PANU:

100997985(INS)

MLEU:

105545324(INS)

RRO:	104677102(INS)

RBB:	108539226(INS)

TFN:	117081143(INS)

PTEH:

111520623(INS)

CJC:	100393089(INS)

SBQ:	101038116(INS)

CIMI:

108288726(INS)

ANAN:

105719893(INS)

MMUR:

105859822(INS)

LCAT:

123642915(INS)

ERUF:

138385441(INS)

PCOQ:

105816531(INS)

OGA:	100958310(INS)

MMU:	16333(Ins1) 16334(Ins2)

MCAL:

110286053 110299132

MPAH:

110326410 110333420

RNO:	24505(Ins1) 24506(Ins2)

MCOC:

116101481

ANU:	117722990(Ins) 117723507

ASYL:

127676302 127678575(Ins)

MUN:	110547298(Ins)

CGE:	100760716(Ins)

MAUA:

101823595(Ins)

PLEU:

114695174(Ins)

PMAV:

102928305(Ins)

MORG:

121457317(Ins)

MFOT:

126498130

AAMP:

119805421(Ins)

CNL:	130880751(Ins)

NGI:	103738986(Ins)

HGL:	101719971(Ins)

CPOC:

100379579(Ins)

CCAN:

109689794

DORD:

105989171(Ins)

DSP:	122102073(Ins)

DMER:

138818692(Ins)

NCAR:

124960685

SVUL:

306640616(ACX6B4_003048)

MMMA:

107157066(Ins)

ITI:	101966207(Ins)

SCIL:

308630657(INS)

MAVE:

308279217(INS)

OPI:

101533865

OCZ:	121150300(INS)

TUP:	102481191(INS)

CFA:	483665(INS)

CLUD:

112663225(INS)

VVP:	112924140(INS)

VLG:	121471415(INS)

NPO:	129503213(INS)

AML:	100483432(INS)

UMR:	121099769(INS)

UAH:	113243960(INS)

UAR:	123775502(INS)

ELK:

111150279

LLV:

125079072

MPUF:

101684928(INS)

MNP:	132016807(INS)

MLK:	131817733(INS)

NVS:	122914590(INS)

MMAQ:

308350425(INS)

ORO:	101383590(INS)

EJU:

114220406

ZCA:	113914580(INS)

MLX:	118015656(INS)

MANO:

123856329(INS)

NSU:	110576080(INS)

LWW:	102747637(INS)

FCA:	493804(INS)

PYU:	121023965(INS)

PBG:	122484127(INS)

PVIV:

125146894(INS)

LRUF:

124527868

LGF:	123602754(INS)

AJU:

113595531

PPAD:

109259395(INS)

PUC:

125911602

PLEZ:

122200535(INS)

HHV:	120226896(INS)

CCRU:

144223279(INS)

BTA:	280829(INS)

BOM:	102274400(INS)

BIU:	109554336(INS)

BJV:	133241617(INS)

BBUB:

102396436(INS)

BKE:	129653550(INS)

CHX:	108634241(INS)

OAS:	114110121(INS)

OCAN:

138426841(INS)

BTAX:

128069208(INS)

CSUM:

138082779(INS)

ODA:	120874170(INS)

CCAD:

122430981(INS)

MREE:

136169852(INS)

OVR:	139029588(INS)

MBEZ:

129548407(INS)

SSC:	397415(INS)

CFR:	116666555(INS)

CDK:	116152037(INS)

VPC:	116285510(INS)

BACU:

103021022(INS)

BMUS:

118899337(INS)

LVE:	103085742(INS)

OOR:	101278494(INS)

LALB:

132526579(INS)

GMF:	115840340(INS)

DDP:	132430174(INS)

SCOO:

307190186(ACYUVP_015459)

PCRS:

137231193(INS)

DLE:	111183606(INS)

PCAD:

112062628(INS)

PSIU:

116758168

PPHC:

136126649(INS)

NASI:

112402369(INS)

HAMP:

307056726(INS)

ECB:	111776000(INS)

EPZ:	103567614(INS)

MYB:

102254396

MYD:	102753598(INS)

MMYO:

118659596 118659608 118659612

MLF:	102430737(INS)

MDT:	132241616 132241847 132241978 132241979 132242351 132242352

MYUM:

139017650 139017651 139017652 139018549 139018550 139018551

PKL:	118713982(INS)

EFUS:

103303257(INS)

POTS:

308234388(INS)

SHON:

118988340(INS)

AJM:	119057541(INS)

PDIC:

114500824(INS)

PHAS:

123807354(INS)

MMF:	118628933(INS)

PPAM:

129068502(INS)

HAI:	109395936(INS)

RFQ:	117030020(INS)

RHII:

308504017(INS)

PALE:

102881117

PGIG:

120584612(INS)

RAY:	107513269(INS)

MJV:	108402614(INS)

TOD:	119249861(INS)

SARA:

101545195(INS) 101551461

SFUM:

130039917(INS)

SETR:

126019098(INS)

LAV:	100661112(INS)

TMU:

101346705

ETF:	101641705(INS)

GAS:	123256044(INS)

AFZ:

127540738

PCW:	110197190(INS)

TVP:	118852918(INS)

PBRV:

138176514(INS)

MLAO:

141516584(INS)

OAA:	114810063(INS)

TACU:

119943512(INS)

GGA:	396145(INS)

PCOC:

116242868(INS)

MGP:	100540225(INS)

CJO:	107314531(INS)

TPAI:

128086622(INS)

LMUT:

125695229(INS)

NMEL:

110400779(INS)

APLA:

101794427(INS)

AACU:

137858173(INS)

OJA:	118167491(INS)

BCLA:

308444561(INS)

ACYG:

106042601(INS)

ABRC:

308196404(INS)

CATA:

118244761(INS)

AFUL:

116489355(INS)

TGU:	100231606(INS)

LSR:	110468670(INS)

VMC:	128809330(INS)

VCHA:

128790092(INS)

AIB:	137476668(INS)

SCAN:

103826754(INS)

PMOA:

120511419(INS)

OTC:	121341561(INS)

PRUF:

121361012(INS)

ATRC:

139590705(INS)

MATE:

118687761(INS)

MAEN:

136558430(INS)

GFR:	102044590(INS)

FAB:	101812165(INS)

OMA:	130254012(INS)

PHI:	102111203(INS)

PMAJ:

107205419(INS)

CCAE:

111930707(INS)

CCW:

104687554

CBRC:

103624930

ACOE:

138111349(INS)

ETL:	114059852(INS)

ZAB:	102072773(INS)

ZLE:	135448840(INS)

ACHL:

103802297(INS)

SVG:	106859791(INS)

MMEA:

130577075(INS)

HRT:	120754549(INS)

SATI:

136363178(INS)

CFAI:

136291729(INS)

CCIC:

134045695(INS)

NNT:	104404955(INS)

SHAB:

115607484(INS)

POCC:

134158917(INS)

FPG:	101915745(INS)

FCH:	102054961(INS)

FRS:	119154205(INS)

CCRI:

104163519(INS)

ACUN:

113481160

ANOC:

141966136(INS)

SURA:

141950348(INS)

TALA:

104368806(INS)

ACHC:

115352123

HALD:

104319005(INS)

HLE:	104829565(INS)

AGEN:

126047226

HHAR:

128153151(INS)

BBUT:

142039922(INS)

GCL:

127017343

CSTI:

104556073(INS)

LDI:	104339708(INS)

MNB:	103768524(INS)

DPUB:

104305807(INS)

PPUS:

135186308(INS)

IIN:	128974108(INS)

AVIT:

104279700(INS)

BRHI:

104488944(INS)

EGZ:	104124907(INS)

NNI:

104010412

PCRI:

104029162(INS)

PCAO:

104047388(INS)

PARX:

142057124(INS)

PADL:

103920695(INS)

AFOR:

103906715(INS)

FGA:	104083782(INS)

CBOR:

142087960(INS)

GSTE:

104256001(INS)

CBOY:

140653567(INS)

MAME:

142409701(INS)

CLV:	102092033(INS)

CNIC:

135989883(INS)

NMAY:

308041328(INS)

MUI:	104536216(INS)

PGUU:

104472141(INS)

PLET:

104617306(INS)

EHS:	104516693(INS)

CMAC:

104484558(INS)

CUCA:

104068903(INS)

PCUR:

138720655(INS)

TEO:	104379612(INS)

BREG:

104639471(INS)

GAME:

129206989(INS)

OHA:	104330120(INS)

ACAR:

104520874(INS)

CEUR:

306725488(INS)

CPEA:

104394306

CVF:	104292587(INS)

RTD:	128909359(INS)

CRID:

134515508(INS)

LMIC:

141741611(INS)

NARQ:

141466120(INS)

AAM:	106497062(INS)

AROW:

112972450(INS)

NPD:	112945254(INS)

TGT:

104570706

DNE:	112978921(INS)

SCAM:

104143748(INS)

ASN:	102378642(INS)

AMJ:	102565762(INS)

CPOO:

109320953(INS)

GGN:	109299505(INS)

PSS:	102445198(INS)

CIZ:	142013985(INS)

CMY:	102935680(INS)

CCAY:

125638588(INS)

LKP:	140913822(INS)

NDS:	141989969(INS)

DCC:

119857525

CPIC:

101937524(INS)

TST:	117876752(INS)

EOB:	135878284(INS)

CABI:

116819349(INS)

MRV:	120404835(INS)

EMQ:	137147981(INS)

ACS:	100565615(ins)

ASAO:

132761878(INS)

PVT:	110076559(INS)

SUND:

121918950(INS)

PBI:	103061255(INS)

PMUR:

107294042(INS)

CTIG:

120311349

TSR:	106547000(INS)

PGUT:

117666068(INS)

PCAE:

139327558(INS)

APRI:

131188828(INS)

PTEX:

113440221(INS)

NSS:	113412472(INS)

VKO:	123021294(INS)

PMUA:

114585088

PRAF:

128402570(INS)

ZVI:

118089274

HCG:	128323861(INS)

GJA:	107123376(INS)

STOW:

125426313 125426951(INS)

EMC:	129324677(INS)

XLA:	108696734(XB5961731.L) 378695(ins.L) 378696(ins.S)

XTR:	100101718(ins)

NPR:	108792002(INS)

RTEM:

120917286(INS)

ACAT:

141112978(INS)

PADS:

140338531(INS)

BBUF:

120980007(INS)

BGAR:

122920015(INS)

DTC:	141052654 141088126(INS)

PWL:	138283242 138283243(INS)

MUO:	115468009(INS)

GSH:	117352114(INS)

DRE:	100534937 30262(ins) 566735(insB)

DAES:

130228581(ins)

SRX:	107707184 107729420 107730741 107734121 107736649 107746436

SANH:

107661260(ins) 107663421 107663422 107666601 107689667

SGH:	107554113 107561280 107596207 107599231 107600181

CCAR:

109085261 109085271 109094548(insb) 122138744

CAUA:

113047664 113049073 113073488 113077182 113114193

CGIB:

127953825 127957935 127971917 128004082 128027077

PTET:

122342085 122344767(ins) 122358096(insb)

LROH:

127163542 127164980(ins) 127176089(insb)

GRF:	141288883(insb) 141335032 141335520 141335576(ins)

OMC:	131537713 131541218(ins) 131553957(insb)

PPRM:

120460588(insb) 120461675(ins)

RKG:	130072624(ins) 130075603(insb) 130088398

SCEP:

307158625(ins)

MAMB:

125259323(insb) 125266058(ins) 125277562

CIDE:

127508035 127512529 127525708

CERY:

137004504 137008206(insb) 137034409(ins)

MASI:

127413002 127427992 127428010 127435195 127435203 127451533

TROS:

130549556(ins) 130561055

TDW:	130419090(ins) 130426124

MANU:

129436052 129440419(ins)

PDAB:

135760253 135783030(ins)

IPU:	108259786 108259964 108280599

IFU:	128603190 128603617 128617816

PHYP:

113525002 113531241(ins)

SMEO:

124379286(ins)

TFD:	113650955(ins)

TVC:	132841226(ins)

CGAR:

128512101(ins) 128544660

NGRA:

132876119(ins)

TRN:	134303106(ins)

AMEX:

103028544(insb) 103030099(ins) 103041971

CMAO:

118800533 118801651(ins) 118806420(insb)

EEE:	113591428(ins)

CHAR:

105898511 105901030(ins) 105902849(insb)

SPIL:

134068550 134076904 134079735 134079797

ASAD:

121708808(ins) 121709285

TRU:

101065226

TFS:	130531736 130537346

TNG:	GSTEN00008749G001 GSTEN00014675G001

NCC:	104961913(ins)

TBEN:

117469588 117475232(insb)

CGOB:

115014742 115018585(ins)

PGEO:

117443454 117454283(insb)

GACU:

117545246 117552873

EMAC:

134860340(insb) 134872400

ELY:	117261385(insb) 117270452(ins)

EFO:	125894470(insb) 125898795(ins)

PLEP:

121938184(ins) 121948354(insb)

SLUC:

116052062(insb) 116060396 116061955(ins)

ECRA:

117951814(insb)

ESP:	116696869(ins)

PFLV:

114562468 114567209

GAT:	120822893(ins)

PPUG:

119215349(ins)

AFB:	129090325 129113266(ins)

CLUM:

117742832(ins)

CANA:

137787968(ins)

CVE:	137888336(ins)

MSAM:

119888918(insb) 119894945(ins)

SCHU:

122880879(insb) 122888298(ins)

EARM:

139291321(insb) 139295320

CUD:	121516567(insb) 121519113(ins)

SPUL:

138598354(insb) 138603078(ins)

LMIX:

132982454(insb) 132988361

HTC:	141792005(ins) 141793692(insb)

ALAT:

119007595 119031601 119031607 119031608

ASTR:

137602938(insb) 137606304(ins)

PKLU:

139207341(insb) 139224731(ins)

LCO:	104923900 104931882 109142434(ins)

MZE:	101468103(ins) 101469513(insb)

ONL:	100692120(ins) 100704156

OAU:	116315148(insb) 116335737(ins)

OLA:	100125446 101172253

OML:	112141334(ins) 112142690 112153519

CSAI:

133447659 133459997(ins) 133460155

XMA:	102225241(ins) 102229304

XCO:	114139621 114153755(ins)

XHE:	116714921 116728047(ins)

PRET:

103470901(insb) 103476384(ins)

PFOR:

103130811 103155894

PLAI:

106937878 106941837

PMEI:

106908579 106928221

GAF:	122837576(insb) 122845354(ins)

PPRL:

129354010(ins) 129362783(insb)

CVG:	107086316 107090300(ins)

CTUL:

119798134(ins)

GMU:	124860812(insb) 124875874(ins)

NFU:	107383905 107386784

KMR:	108237967(insb) 108238926 108250678(ins)

ALIM:

106525530 106529800 106536859

NWH:	119409113(insb) 119419923 119420379(ins)

LTU:	140279541 140279658(ins) 140318311(insb)

MCEP:

125008716(insB) 125021226(ins)

AOCE:

111566177 111587296(ins) 111588046(insb)

EJA:	138194919(ins) 138211340(insb)

BFRE:

138619896(insb) 138635548(ins)

LCF:	108882783 108890171 108890250 108893384

CSEM:

103395680(ins)

POV:	109624754 109643669(ins) 109645588

SSEN:

122778685(insb) 122779138(ins)

SSOE:

131458127(ins) 131472933(insb)

HHIP:

117769264(insb) 117774639(ins)

HSP:	118112388 118122248(ins)

PPLT:

128446204 128456805(ins)

SMAU:

118300315(ins) 118301540 118319531

SDU:	111221377(ins) 111226678 111234582

SLAL:

111653396(ins) 111664630 111672131

XGL:	120785499(insb) 120802773 120802802

HCQ:	109517881 109524473 109528912

SSCV:

125981728 125994063

SBIA:

133491810 133491944 133508725

PEE:	133407894 133416067 133416094

PTAO:

133467054(ins) 133467349 133485005

BPEC:

110156469 110172772

ENY:	140360269 140360319(ins)

MALB:

109952337 109955249 109959979 109968712

BSPL:

114864486(insb) 114869723 114869891(ins)

SJO:	128363077(insb) 128371064 128371442

SSCO:

133986009(insb) 133994120 133994166

TTY:	137188744(insb) 137195030 137195041

GMH:	115547383 115547985 115552431

SASA:

106567474(INS) 106603941(INS) 106612054

STRU:

115148215 115153684 115190165

OTW:	112234673 112255913 112259393

OMY:	100136702 100136703 118946006

OGO:	123995144 124000570

ONE:	115104644 115124592 115129128

OKI:	109873252 109892188 109908655

OKE:	118390715 118391666 127913761

OMM:	135538945 135545562 135547988

OCLA:

139390811 139390960 139419409 139422095

SALP:

111950763 111967220 111981304

SNH:	120044421 120046921 120056420 120062047

SFON:

129827249 129867768 129868938

CCLU:

121533215 121574459 121580143

ELS:	105021727 105025960

OEP:	134013854 134032637

SFM:	108934283(ins)

PKI:	111850821(ins)

AANG:

118216348 118235395 118235396 118235397

AROT:

135243027 135263635 135263636 135263637

CCOG:

133115437

LOC:	102694874 102695073

PSPA:

121295106 121305882 121330389

ARUT:

117434440

PSEX:

120517688(ins) 120542969

LCM:	102348278(INS)

CMK:	103186003(ins)

RTP:

CPLA:

CPUN:

HOC:

SCAU:

LERI:

HAKA:

PMRN:

116958096(INS)

LRJ:

133347390

AFIL:

140157165 140164572

PFLL:

139118459 139147789

DME:	Dmel_CG14167(Ilp3) Dmel_CG14173(Ilp1) Dmel_CG33273(Ilp5) Dmel_CG6736(Ilp4) Dmel_CG8167(Ilp2)

DER:	6546016 6546017 6546018 6546019 6546022

DSE:	6605101 6605102 6605103 6605104 6605107

DSI:	Dsimw501_GD12890(Dsim_GD12890) Dsimw501_GD12891(Dsim_GD12891) Dsimw501_GD12892(Dsim_GD12892) Dsimw501_GD14217(Dsim_GD14217) Dsimw501_GD14218(Dsim_GD14218)

DYA:	Dyak_GE20299 Dyak_GE20300(Dyak_Ilp4) Dyak_GE20301 Dyak_GE21719 Dyak_GE21720

DSR:	110187335 110187345 110190564 110190613 110190614 110190615 110190725

DPO:	117185171 4813355 4813890 6900736 6900737

DPE:	113566445 6602817 6602822 6602823

DMN:	108152247 108152248 108152249 108152251 108152252

DWI:	124460625 26529296 6645318 6645319

DGR:	6556876 6556893 6556922 6556940 6556947 6557001

DMO:	Dmoj_GI12279 Dmoj_GI12280 Dmoj_GI12281 Dmoj_GI13033 Dmoj_GI13035

DAZ:	108613072 108613073 108613074 108613075

DNV:	108651279 108651280 108651282 108651283

DHE:	111598695 111598707 111598708 111598709 111598755

CCAT:

101450959 101462409 101462588 101463004 105665118 105665119 105665120

BOD:	106617457 106617580 106617597 106617599

BDR:	105231314 105231315 105231318 105233014 105233484 109580026 125778913

RZE:

108380483

AOQ:	129238784 129240269 129241116 129241117 129241118 129241935 129242021 129242774 129242798 129242876 129242919 129242965 129242979

ALUD:

128858690 128861292 128861295 128861362 128861491 128861594 128861656 128862412

TDA:	119662469 119673065 119673479 119679732

MDE:	101889921 101893775 101893945 101894101 101894119 105262243 109612103 109613673 131800333 131805909 131805913 131805922 131805926 131806812 131806854 131806855 131806924 131806928

SCAC:

106086464 106088789 106094793 106094794 106094866 106094921 131994098 131994225 131994335 131995103 131998492

LCQ:	111675091 111675996 124420418

LSQ:	119602639 119602640 119602641 119602642 119602643 119613806

CVJ:	135955467 135963221 135963456

GFS:	119633905 119643170 119645304

ECOE:

129944045 129944100 129944174 129944717 129944718 129946663 129948147 129948215 129948286 129948376 129948475 129951004 129952867

CLON:

129613831 129613867

AGA:	1275326 1275327

ACOZ:

120958288 120959058 120960184

AARA:

120900028 120903604 120903606

AMER:

121598295 121599717 121600169

ASTE:

118506112 118506113 118506114

AMAP:

126556359 126556383

AFUN:

125767090 125767106

AMOU:

128309594 128310331 128310332 128310333

AMRS:

AALI:

ADAR:

ACOS:

AAG:	110679401 5567483 5567485 5567486

AALB:

109403160 109403183 109622174 115268336

ASUA:

134223996 134223997 134223998 134226883

CQU:	CpipJ_CPIJ018049 CpipJ_CPIJ018050 CpipJ_CPIJ018051 CpipJ_CPIJ018052

CPII:

120421839 120421843 120421844

CBRI:

134826899

CNS:

116340098

BCOO:

119066837 119069766 119074792

LLL:

129793671

PPAP:

129804527

BMOR:

100146109(Bbx-e1) 100146110(Bbx-f1) 100169657(Bbx-a4) 100169708(Bbx-a7) 100169712(Bbx-a3) 100169716(Bbx-b7) 100169719(Bbx-b1) 100169720(Bbx-b4) 100169723(Bbx-b6) 100169726(Bbx-g1) 100653512(BmILP) 101736783 101741759

BMAN:

114239790 114239809 114249637 114249638 114249639 114249640 114249643 114249645 114249646 114249648 114249649 114249650 114252200 114252201 114252205 114252555 114252556

MSEX:

115447806 115447807 115447808 115447809 115447810 115447811 115447813 115447814 115447816 115447817 115447818 115447819 115456422 115456431 119189397

DPL:	KGM_200042 KGM_202681 KGM_202682 KGM_206157

BANY:

112042917 112045526 112045533 112045735 112050564 112053796

MJU:	123872810 123880583

VCD:	124544505(LOC124544505)

MCIX:

123656285 123656286

PMAC:

106709220 106715286 106720292

PPOT:

106099949 106099950 106099951 106105649

PXU:	106113421 106126592

BPHI:

137919952 137932321 137933437

PRAP:

110992988 110999357

PNAP:

125048599

ZCE:	119830987 119833516 119838279 119838563 119840923

CCRC:

123696434

LSIN:

126967259 126977031

AAGE:

121726771 121728819 121732858

HAW:	110374203 110384007

HZE:

124632454

TNL:	113495219 113497725 113500591 113506709

SLIU:

111349683 111354087 111355654 111355766 111358241

OFU:	114357258 114361879 114362154 114363626 114363628

ONU:

135073657

ATRA:

106142818 132902267

GMW:	113515626 113523444 116412952 128200457

ECLR:

140743305 140756201

PXY:	105384156(LOC105384156) 119691088(LOC119691088)

PGW:

126380800

LGLY:

125226711 125228952 125231850 125231851 125240640

CSTB:

134745284

CFUM:

141429978 141435820 141445438

TCA:

100142381

TMOL:

138133104 138133393 138141398

DPA:

109535797

ESIM:

136410862 136412752

EFOR:

136344532 136345719

SOY:	115875219 115885302

RFG:	143194164 143195856 143196037 143205090

AGRG:

126733737

ATD:	109597751 109603602 109605527

CSET:

123309733 123309734 123317986

HAXR:

123684182 123684457 123684530

AGB:	108912000 108912816

LDC:	111503248 111517962 111517971

DVV:	114324239 114324240 114324241 114349182

NVL:	108569818 108569829 108569830

APLN:

108741730

PPYR:

116174659 116174660 116174701

OTU:	111415302 111423319

CCRN:

123293232 123298162 123298163

ACER:

ALAB:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:	105252710 105255165 105257206 112637902 112637903 112638354 112638377 112638378 112638379 112638381 112638382 112639387

PGC:

109860861

OBO:	105278524(ILP-2)

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

CTYP:

141528146(Ilp-2)

FAS:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

API:	100161832 100568938 100570058 100574788 100575361

DNX:	107166147 107169120

AGS:	114120744 114127532

RMD:

113558495

DVT:	126894333 126902889

BTAB:

109038562 109038563

DCI:	103505565 103505566

CLEC:

112127432

HHAL:

106683319

NLU:	111046284 111053537 111053538

LDA:	142321482 142325722 142330883 142331384 142332203 142332243 142332419

HVI:	124358050 124358051 124358519 124358573 124358775 124358787 124370709

MQU:	128984242 128984730 128987144 128987191 128987991

FOC:

113208572

TPAL:

117650332 117650333

ZNE:	110829699 110832106 110832107 110832108

CSEC:

111861297 111862713

PAME:

138708564 138708647 138709476 138709477 138709998 138709999 138710097 138715371

BROR:

134533982 134541936 134542270 134542369

IEL:	124161974(LOC124161974) 124162527(LOC124162527)

HAMR:

139688536 139698046 139700709

FCD:

110851216

DPX:	DAPPUDRAFT_300602

AFRA:

136037641 136038353

EAF:	111704221 111706369

TCF:

PCHN:

SPRM:

PPOI:

DSV:

DALB:

RSAN:

RMP:

VDE:

VJA:

CSCU:

111624064 111634212 111637650 111637652 111637654

CVS:	136972364 136972758 136988340 136988348 136988824

PTEP:

107444576 107448965 107448973 107451234 107455901

ABRU:

129961038 129985083 129989158 129989164 129989240 129989469 129989475

UDV:	129226487 129226554 129226929 129226931

SDM:	118185031 118196017 118196019 118197391

LPOL:

106457310 106457397 106459415 106469140 111083358

TSP:

Tsp_10902

LGI:	LOTGIDRAFT_232734

PVUL:

126810685

LSAX:

138961522

BGT:

106057571

GAE:	121369741 121372018

HRF:	124125324 124133455

HRJ:	124256453 124271354 124282699

HASI:

137268634 137287186 137287252

HCRA:

139455307 139475005

CANU:

128184248

CVN:	111101100 111102913

OED:	125674924 125675205 125675602

MMER:

123532476 123538929

RPHI:

132719512 132720387 132720388 132745906 132745907 132754243 132757475

MAEA:

OSN:

LJP:

LAK:

EGL:

LLON:

NVE:	116601477 116603593

ATEN:

116292330 116292360 116304936

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

Reference

PMID:11937037

Authors

Lizcano JM, Alessi DR

Title

The insulin signalling pathway.

Journal

Curr Biol 12:R236-8 (2002)
DOI:10.1016/S0960-9822(02)00777-7

Reference

PMID:2397023

Authors

Sawa T, Ohgaku S, Morioka H, Yano S

Title

Molecular cloning and DNA sequence analysis of preproinsulin genes in the NON mouse, an animal model of human non-obese, non-insulin-dependent diabetes mellitus.

Journal

J Mol Endocrinol 5:61-7 (1990)
DOI:10.1677/jme.0.0050061

Sequence

[mmu:16333 16334]

All links

Gene (60)   
   MGENES (18)   
   RefGene (31)   
   OC (11)   
All databases (60)   

Download RDF

ORTHOLOGY: K05450

Entry

K05450                      KO

Symbol

PDGFC_D

Name

platelet derived growth factor C/D

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04020

Calcium signaling pathway

map04072

Phospholipase D signaling pathway

map04151

PI3K-Akt signaling pathway

map04510

Focal adhesion

map04518

Integrin signaling

map04540

Gap junction

map04810

Regulation of actin cytoskeleton

map05215

Prostate cancer

map05218

Melanoma

map05231

Choline metabolism in cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
   04014 Ras signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
   04015 Rap1 signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
   04020 Calcium signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
   04072 Phospholipase D signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
   04151 PI3K-Akt signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
  09133 Signaling molecules and interaction
   04518 Integrin signaling
    K05450  PDGFC_D; platelet derived growth factor C/D
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05450  PDGFC_D; platelet derived growth factor C/D
   04540 Gap junction
    K05450  PDGFC_D; platelet derived growth factor C/D
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05450  PDGFC_D; platelet derived growth factor C/D
09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    K05450  PDGFC_D; platelet derived growth factor C/D
  09162 Cancer: specific types
   05218 Melanoma
    K05450  PDGFC_D; platelet derived growth factor C/D
   05215 Prostate cancer
    K05450  PDGFC_D; platelet derived growth factor C/D
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05450  PDGFC_D; platelet derived growth factor C/D
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05450  PDGFC_D; platelet derived growth factor C/D
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Growth factors (RTK binding)
   K05450  PDGFC_D; platelet derived growth factor C/D

Other DBs

GO:

0005161

Genes

HSA:	56034(PDGFC) 80310(PDGFD)

PTR:	466765(PDGFD) 736477(PDGFC)

PPS:	100982459(PDGFC) 100992738(PDGFD)

GGO:	101134877(PDGFD) 101144807(PDGFC)

PON:	100172718(PDGFD) 100437861(PDGFC)

PPYG:

129007154(PDGFD) 129035343(PDGFC)

NLE:	100585549(PDGFC) 100586178(PDGFD)

HMH:	116463464 116463488 116476871(PDGFD)

SSYN:

129479579(PDGFD) 129481171(PDGFC)

MCC:	700236(PDGFC) 704310(PDGFD)

MCF:	101925936(PDGFD) 102132043(PDGFC)

MTHB:

126936264 126954312

MNI:	105488621(PDGFC) 105493695(PDGFD)

CSAB:

103236438(PDGFC) 103248362(PDGFD)

CATY:

105588762(PDGFD) 105597890(PDGFC)

PANU:

101003924(PDGFD) 101025143(PDGFC)

TGE:	112606868(PDGFD) 112625330(PDGFC)

MLEU:

105532330(PDGFC) 105542755(PDGFD)

RRO:	104655283(PDGFD) 104658109(PDGFC)

RBB:	108529019(PDGFC) 108534757(PDGFD)

TFN:	117080013(PDGFD)

PTEH:

111540080(PDGFD) 111553384(PDGFC)

CANG:

105500952(PDGFD) 105524451(PDGFC)

CJC:	100393010(PDGFC) 100398033(PDGFD)

SBQ:	101038849(PDGFC) 101049234(PDGFD)

CIMI:

108302426(PDGFC) 108315446(PDGFD)

ANAN:

105714539(PDGFC) 105719307(PDGFD)

CSYR:

103265612(PDGFC) 103267441(PDGFD)

MMUR:

105874557(PDGFD) 105881767(PDGFC)

LCAT:

123638516(PDGFC) 123641878(PDGFD)

ERUF:

138383874(PDGFD) 138398621(PDGFC)

PCOQ:

105817331(PDGFC) 105822163 105822164

OGA:	100962660(PDGFD) 100964580(PDGFC)

MMU:	54635(Pdgfc) 71785(Pdgfd)

MCAL:

110290924(Pdgfc) 110301590(Pdgfd)

MPAH:

110319957(Pdgfc) 110327924(Pdgfd)

RNO:	66018(Pdgfd) 79429(Pdgfc)

MCOC:

116072446(Pdgfd) 116093026(Pdgfc)

ANU:	117707723(Pdgfc) 143439709(Pdgfd)

ASYL:

127683235(Pdgfc) 127689462(Pdgfd)

MUN:	110540260(Pdgfd) 110542507(Pdgfc)

CGE:	100756952(Pdgfd) 100765334(Pdgfc)

MAUA:

101829713(Pdgfc) 101834115(Pdgfd)

PROB:

127216911(Pdgfd) 127232870(Pdgfc)

PLEU:

114700491(Pdgfc) 114708007(Pdgfd)

PMAV:

102904670(Pdgfd) 102914867(Pdgfc)

MORG:

121451729(Pdgfd) 121452866(Pdgfc)

MFOT:

126493287 126511557

AAMP:

119810057(Pdgfd) 119826417(Pdgfc)

CNL:	130865878(Pdgfc) 130873681(Pdgfd)

NGI:	103731702(Pdgfd) 103751038(Pdgfc)

HGL:	101696768(Pdgfd) 101710927(Pdgfc)

CPOC:

100713757(Pdgfd) 100722571(Pdgfc)

CCAN:

109701575(Pdgfc) 109702404(Pdgfd)

DORD:

105980590(Pdgfd) 105995943(Pdgfc)

DSP:	122097855(Pdgfc) 122104212(Pdgfd)

DMER:

138820620(Pdgfc) 138821387 138838829

PLOP:

125349532(Pdgfd) 125364930(Pdgfc)

NCAR:

124960701 124994986

SVUL:

306638708(PDGFD) 306669526(PDGFC)

MMMA:

107141288(Pdgfc) 107145711(Pdgfd)

ITI:	101955098(Pdgfd) 101974399(Pdgfc) 106144716

SCIL:

308643063(PDGFD) 308655119(PDGFC)

MAVE:

308264591(PDGFC) 308264713(PDGFD)

OCU:	100008912(PDGFD) 100350272

OPI:	101529042(PDGFD) 101529308(PDGFC)

OCZ:	121150421(PDGFC) 121154272(PDGFD)

TUP:	102485007(PDGFD) 102487522(PDGFC)

GVR:	103586679(PDGFD) 103590948(PDGFC)

CFA:	479460(PDGFD) 482666(PDGFC)

CLUD:

112654298(PDGFC) 112671430(PDGFD)

VVP:	112912529 112925942(PDGFD)

VLG:	121481069(PDGFC) 121499558(PDGFD)

NPO:	129497471(PDGFD) 129516878(PDGFC)

AML:	100479872(PDGFD) 100481171(PDGFC)

UMR:	103658054(PDGFC) 103662543(PDGFD)

UAH:	113255787(PDGFC) 113260127(PDGFD)

UAR:	123792511(PDGFD) 123793193(PDGFC)

ELK:	111153783 111155335

LLV:	125079346 125093106

MPUF:

101686980(PDGFD) 101693911(PDGFC)

MNP:	132000852(PDGFC) 132029044(PDGFD)

MLK:	131831691(PDGFC) 131834784(PDGFD)

NVS:	122889497(PDGFC) 122912247(PDGFD)

MMAQ:

308338791(PDGFC) 308350610(PDGFD)

ORO:	101363701(PDGFD) 101378889(PDGFC)

EJU:	114210145(PDGFC) 114211231(PDGFD)

ZCA:	113925050(PDGFC)

MLX:	118013160(PDGFD) 118022209(PDGFC)

MANO:

123848137(PDGFC) 123857872(PDGFD)

NSU:	110586385(PDGFD) 110588527(PDGFC)

LWW:	102742552(PDGFD) 102745087(PDGFC)

FCA:	101084984(PDGFD) 101088742(PDGFC)

PYU:	121020761(PDGFD) 121028117(PDGFC)

PCOO:

112858328(PDGFC) 112865896(PDGFD)

PBG:	122475093(PDGFC) 122482899(PDGFD)

PVIV:

125146630(PDGFD) 125164369(PDGFC)

LRUF:

124504901 124520961

LGF:	123591004(PDGFC) 123600577(PDGFD)

AJU:	106974876 106976474

PTG:	102949957(PDGFD) 102970530(PDGFC)

PPAD:

109257520(PDGFD) 109262483(PDGFC)

PUC:	125910662 125923778

PLEZ:

122199435(PDGFD) 122217758(PDGFC)

HHV:	120223081(PDGFC) 120246757(PDGFD)

CCRU:

144222524(PDGFC) 144236396(PDGFD)

BTA:	525931(PDGFD) 613787(PDGFC)

BOM:	102273267(PDGFD) 102274384(PDGFC)

BIU:	109569805(PDGFD) 109571395(PDGFC)

BJV:	133228679(PDGFC) 133261625(PDGFD)

BBUB:

102392849(PDGFC) 102411002(PDGFD)

BKE:	129628055(PDGFD) 129629520(PDGFC)

BBIS:

104985766(PDGFC) 104987815(PDGFD)

CHX:	102168651(PDGFD) 102168934(PDGFC)

OAS:	101112600(PDGFC) 101117784(PDGFD)

OCAN:

138421065(PDGFD) 138422549(PDGFC)

BTAX:

128060743(PDGFD) 128062428(PDGFC)

CSUM:

138092477(PDGFD) 138093887(PDGFC)

ODA:	120871511(PDGFC) 120876152(PDGFD)

CCAD:

122449654(PDGFD) 122453611(PDGFC)

MREE:

136145406(PDGFC) 136174969(PDGFD)

OVR:	110131303(PDGFC) 110141487(PDGFD)

MBEZ:

129542873(PDGFC) 129554238(PDGFD)

SSC:	100515267(PDGFC) 100524161(PDGFD)

CFR:	102508964(PDGFC) 102515439(PDGFD)

CBAI:

105067589(PDGFD) 105069374(PDGFC)

CDK:	105101177(PDGFC) 116155424(PDGFD)

VPC:	102539007(PDGFD) 102541506(PDGFC)

BACU:

103015925(PDGFD) 103019677(PDGFC)

BMUS:

118895652(PDGFC) 118900139(PDGFD)

LVE:	103076387(PDGFC) 103085046(PDGFD)

OOR:	101278539(PDGFC) 101290342(PDGFD)

LALB:

132519604(PDGFC) 132525374(PDGFD)

GMF:	115841628(PDGFD) 115858148(PDGFC)

DDP:	132425261(PDGFC) 132428990(PDGFD)

SCOO:

307185702(PDGFC) 307190558(PDGFD)

PCRS:

137224101(PDGFC) 137230801(PDGFD)

DLE:	111167562(PDGFD) 111179012(PDGFC)

PCAD:

102985889(PDGFD) 102995661(PDGFC)

PSIU:

116754109(PDGFC) 116758674(PDGFD)

PPHC:

136123836(PDGFC) 136127346(PDGFD)

NASI:

112400383(PDGFC) 112415757(PDGFD)

HAMP:

307055428(PDGFD) 307056843(PDGFC)

ECB:	100061488(PDGFD) 100062015(PDGFC)

EPZ:	103547315(PDGFC) 103558709(PDGFD)

EAI:	106833032(PDGFC) 106843123(PDGFD)

MYB:	102240259(PDGFD) 102248385(PDGFC)

MYD:	102766117(PDGFC) 102772727(PDGFD)

MMYO:

118658606(PDGFC) 118664382(PDGFD)

MLF:	102418575(PDGFD) 102442814(PDGFC)

MDT:	132235407(PDGFC) 132240569(PDGFD)

MYUM:

139010665(PDGFC) 139017506(PDGFD)

PKL:	118710923(PDGFC) 118712932(PDGFD)

EFUS:

103288794(PDGFC) 103293793(PDGFD)

POTS:

308233942(PDGFD) 308250515(PDGFC)

MNA:	107527538(PDGFC) 107532411(PDGFD)

DRO:	112312671(PDGFC) 112314347(PDGFD)

SHON:

118995347(PDGFC) 119000403(PDGFD)

AJM:	119034635(PDGFC) 119046553(PDGFD)

PDIC:

114500653(PDGFD) 114504215(PDGFC)

PHAS:

123805628(PDGFD) 123814141(PDGFC)

MMF:	118615386(PDGFC) 118629069(PDGFD)

PPAM:

129072575(PDGFC) 129086014(PDGFD)

HAI:	109372936(PDGFC) 109394938(PDGFD)

RFQ:	117031167(PDGFD) 117038535(PDGFC)

RHII:

308503664(PDGFD) 308509594(PDGFC)

PALE:

102890668(PDGFC) 102894123(PDGFD)

PGIG:

120599685(PDGFD) 120613440(PDGFC)

PVP:	105292199(PDGFC) 105297442(PDGFD)

RAY:	107507553(PDGFC) 107520204(PDGFD)

MJV:	108390154(PDGFD) 108393368(PDGFC)

TOD:	119234253(PDGFC) 119242140(PDGFD)

SARA:

101538791(PDGFC) 101543883(PDGFD)

SFUM:

130024334(PDGFD) 130028265(PDGFC)

SETR:

126003432(PDGFC) 126016055(PDGFD)

LAV:	100661451(PDGFD) 100672750(PDGFC)

TMU:	101358075 101360702

ETF:	101647643(PDGFC) 101654830(PDGFD)

DNM:	101415497(PDGFD) 101443644(PDGFC)

MDO:	100011261(PDGFD) 100023701(PDGFC)

GAS:	123241052(PDGFD) 123252942(PDGFC)

SHR:	100916102(PDGFD) 100928148(PDGFC)

AFZ:	127540884 127554931

PCW:	110213688(PDGFC) 110214961(PDGFD)

TVP:	118835534(PDGFD) 118852568(PDGFC)

PBRV:

138155340(PDGFD) 138175195(PDGFC)

MLAO:

141508188(PDGFD) 141517750(PDGFC)

OAA:	100078558(PDGFD) 100079757(PDGFC)

TACU:

119935805(PDGFC) 119941367(PDGFD)

GGA:	395469(PDGFC) 418978(PDGFD)

PCOC:

116230620(PDGFD) 116243135(PDGFC)

MGP:	100543088(PDGFD) 100547981(PDGFC)

CJO:	107308377(PDGFD) 107313060(PDGFC)

TPAI:

128074814(PDGFD) 128084384(PDGFC)

LMUT:

125689229(PDGFD) 125691815(PDGFC)

NMEL:

110389823(PDGFD) 110397304(PDGFC)

APLA:

101789650(PDGFC) 101798843(PDGFD)

AACU:

137850010(PDGFD) 137856102(PDGFC)

OJA:	118166709(PDGFC) 118167896(PDGFD)

BCLA:

308442696(PDGFC) 308445770(PDGFD)

ACYG:

106032364(PDGFC) 106034125(PDGFD)

ABRC:

308188525(PDGFD) 308193700(PDGFC)

CATA:

118245944(PDGFD) 118249045(PDGFC)

AFUL:

116488844(PDGFC) 116490799(PDGFD)

TGU:	100217775(PDGFC) 100221512(PDGFD)

LSR:	110470019(PDGFD) 110475433(PDGFC)

VMC:	128803836(PDGFD) 128806236(PDGFC)

VCHA:

128784262(PDGFD) 128786944(PDGFC)

AIB:	137469058(PDGFD) 137472264(PDGFC)

SCAN:

103812525(PDGFD) 103826223(PDGFC)

PMOA:

120498043(PDGFC) 120506688(PDGFD)

OTC:	121342519(PDGFD) 121348428(PDGFC)

PRUF:

121360372(PDGFC) 121364229(PDGFD)

ATRC:

139592298(PDGFC) 139593344(PDGFD)

MATE:

118686648(PDGFC) 118692461(PDGFD)

MAEN:

136555997(PDGFC) 136570297(PDGFD)

GFR:	102035549(PDGFC) 102044886(PDGFD)

FAB:	101806397(PDGFD) 101808607(PDGFC)

OMA:	130252297(PDGFD) 130252585(PDGFC)

PHI:	102106969(PDGFC) 102112153(PDGFD)

PMAJ:

107203600(PDGFC) 107209392(PDGFD)

CCAE:

111923382(PDGFD) 111927858(PDGFC)

CCW:	104690110(PDGFD) 104697317(PDGFC)

CBRC:

103617374(PDGFC) 103617945(PDGFD)

ACOE:

138109704(PDGFC) 138110068(PDGFD)

ETL:	114057056(PDGFC) 114065863(PDGFD)

ZAB:	102067367(PDGFC) 102068610(PDGFD)

ZLE:	135446654(PDGFC) 135450358(PDGFD)

ACHL:

103806982(PDGFC)

SVG:	106857535(PDGFC) 106859378(PDGFD)

MMEA:

130576292(PDGFD) 130578882(PDGFC)

HRT:	120749255(PDGFD) 120752838(PDGFC)

SATI:

136357582(PDGFD) 136360429(PDGFC)

CFAI:

136285078(PDGFD) 136291222(PDGFC)

CCIC:

134044484(PDGFC) 134057602(PDGFD)

NNT:	104408848(PDGFD) 104410372(PDGFC)

SHAB:

115604363(PDGFD) 115610402(PDGFC)

POCC:

134157945(PDGFC) 134161956(PDGFD)

FPG:	101910328(PDGFD) 101915028(PDGFC)

FCH:	102048020(PDGFC) 102052290(PDGFD)

FRS:	119143606(PDGFC) 119143757(PDGFD)

CCRI:

104158441(PDGFD) 104166473(PDGFC)

ACUN:

113479700(PDGFC) 113484247(PDGFD)

ANOC:

141959778(PDGFC) 141965185(PDGFD)

SURA:

141939771(PDGFD) 141942138(PDGFC)

TALA:

104359460(PDGFC) 104369082(PDGFD)

ACHC:

115346275(PDGFC) 115353500(PDGFD)

HALD:

104324649(PDGFD) 104325380(PDGFC)

HLE:	104828445(PDGFD) 104843371(PDGFC)

AGEN:

126048418 126052801

HHAR:

128137212(PDGFC) 128153434(PDGFD)

BBUT:

142031707(PDGFC) 142041330(PDGFD)

GCL:	127015740 127023694

CSTI:

104558453(PDGFD) 104560306(PDGFC)

LDI:	104344045(PDGFC) 104354057(PDGFD)

MNB:	103777188(PDGFD) 103782038(PDGFC)

DPUB:

104296914(PDGFD) 104298789(PDGFC)

PPUS:

135178132(PDGFC) 135189936(PDGFD)

IIN:	128968650(PDGFC) 128972341(PDGFD)

AVIT:

104279482(PDGFC) 104279528(PDGFD)

BRHI:

104496878(PDGFD) 104500423(PDGFC)

EGZ:	104124151(PDGFC) 104133608(PDGFD)

NNI:	104021357(PDGFC) 104023065(PDGFD)

PCRI:

104033217

PCAO:

104041747(PDGFC) 104047654(PDGFD)

PARX:

142052235(PDGFD) 142056362(PDGFC)

PADL:

103915458(PDGFD) 103918093(PDGFC)

AFOR:

103895107(PDGFD) 103902328(PDGFC)

FGA:	104078564(PDGFC) 104084122(PDGFD)

CBOR:

142077842(PDGFD) 142081978(PDGFC)

GSTE:

104254515(PDGFC)

CBOY:

140646538(PDGFD) 140652369(PDGFC)

MAME:

142404346(PDGFD) 142409180(PDGFC)

CLV:	102087107(PDGFC) 102088608(PDGFD)

CNIC:

135988255(PDGFC) 136003212(PDGFD)

NMAY:

308039897(PDGFC) 308046005(PDGFD)

MUI:	104538562(PDGFC)

PGUU:

104466900(PDGFC)

PLET:

104615766(PDGFC)

EHS:	104511114(PDGFD) 104516630(PDGFC)

CMAC:

104479793(PDGFD) 104481214(PDGFC)

CUCA:

104059429(PDGFD) 104063521(PDGFC)

PCUR:

138720081(PDGFC) 138735470(PDGFD)

TEO:	104379972(PDGFC) 104382755(PDGFD)

BREG:

104637340(PDGFC) 104641405(PDGFD)

GAME:

129205835(PDGFC) 129215449(PDGFD)

OHA:	104331666(PDGFC) 104333036(PDGFD)

ACAR:

104519714(PDGFC)

CEUR:

306717382(PDGFC) 306724325(PDGFD)

CPEA:

104387270(PDGFC) 104390276(PDGFD)

CVF:	104290309(PDGFD) 104294190(PDGFC)

RTD:	128901348(PDGFD) 128910506(PDGFC)

CRID:

134513406(PDGFD) 134516641(PDGFC)

LMIC:

141736482(PDGFD) 141744246(PDGFC)

NARQ:

141464779(PDGFC) 141465163(PDGFD)

AAM:	106491877(PDGFC) 106495523(PDGFD)

AROW:

112976560(PDGFD) 112976710(PDGFC)

NPD:	112949314(PDGFC) 112951854(PDGFD)

TGT:	104567788(PDGFC) 104569851(PDGFD)

DNE:	112987436(PDGFD) 112995316(PDGFC)

SCAM:

104145629(PDGFC) 104146435(PDGFD)

ASN:	102378690(PDGFC) 102380973(PDGFD)

AMJ:	102569106(PDGFC) 102572032(PDGFD)

CPOO:

109305540(PDGFD) 109309700(PDGFC)

GGN:	109300845(PDGFC) 109302217(PDGFD)

PSS:	102452310(PDGFC)

CIZ:	142007993(PDGFD) 142012597(PDGFC)

CMY:	102930493(PDGFD) 102939099(PDGFC)

CCAY:

125634000(PDGFD) 125635610(PDGFC)

LKP:	140909356(PDGFD) 140910479(PDGFC)

NDS:	141986508(PDGFC) 141990235(PDGFD)

DCC:	119849934(PDGFD) 119855275(PDGFC)

CPIC:

101938348(PDGFD) 101944573(PDGFC)

TST:	117871165(PDGFD) 117877938(PDGFC)

EOB:	135879484(PDGFC) 135895454(PDGFD)

CABI:

116819401(PDGFD) 116824088(PDGFC)

MRV:	120368976(PDGFD) 120407035(PDGFC)

EMQ:	137155506(PDGFC) 137166093(PDGFD)

ACS:	100551866(pdgfd) 100568114(pdgfc)

ASAO:

132772192(PDGFD) 132776776(PDGFC)

PVT:	110072781(PDGFC) 110091114(PDGFD)

SUND:

121924728(PDGFD) 121931942(PDGFC)

PBI:	103051428(PDGFC) 103065334(PDGFD)

PMUR:

107290460(PDGFC) 107294823(PDGFD)

CTIG:

120312052 120313888(PDGFD) 120315885(PDGFC)

TSR:	106541330 106551812(PDGFD)

PGUT:

117660925(PDGFD) 117674715(PDGFC)

PCAE:

139317051(PDGFD) 139320287(PDGFC)

APRI:

131199549(PDGFD) 131202897(PDGFC)

PTEX:

113435877(PDGFC) 113440508(PDGFD)

NSS:	113417310(PDGFD) 113417441(PDGFC)

VKO:	123023846(PDGFC) 123029234(PDGFD)

PMUA:

114595668(PDGFD) 114603981(PDGFC)

PRAF:

128412597(PDGFD) 128420935(PDGFC)

ZVI:	118083339(PDGFC) 118085232(PDGFD)

HCG:	128326545(PDGFC) 128351582(PDGFD)

GJA:	107126145(PDGFD) 107126248(PDGFC)

STOW:

125431530(PDGFD) 125440228(PDGFC)

EMC:	129326163(PDGFD) 129336424(PDGFC)

XLA:	108699243(pdgfc.L) 108706647(pdgfc.S) 108707572 108709984(pdgfd.S)

XTR:	100492060(pdgfd) 100494492(pdgfc)

NPR:	108789641(PDGFC)

RTEM:

120920251(PDGFC) 120929043(PDGFD)

ACAT:

141112676(PDGFC) 141126996(PDGFD)

PADS:

140325018(PDGFD) 140326936(PDGFC)

BBUF:

120990068(PDGFC) 120996391(PDGFD)

BGAR:

122931035(PDGFD) 122942494(PDGFC)

DTC:	141069066(PDGFD) 141091101(PDGFC)

HSQ:	130358574(PDGFC)

PCOB:

134920038(PDGFC)

PWL:	138248627(PDGFD) 138303766(PDGFC)

MUO:	115461634(PDGFC) 115468494(PDGFD)

GSH:	117359113(PDGFC) 117363077(PDGFD)

DRE:	100535718(pdgfd) 560564(pdgfc)

DAES:

130241047(pdgfc) 130241687(pdgfd)

SRX:	107723796 107725770 107740106 107756229

SANH:

107669083 107670136 107673893 107689581

SGH:	107560832 107566897 107602582(pdgfc)

CCAR:

109087122 109102734(pdgfc) 122139891 122147526

CAUA:

113057766 113057995 113058810 113090041 113092932 113114617(pdgfd)

CGIB:

127971762 127972778 128027171 128029078

PTET:

122358304(pdgfc) 122359132(pdgfd)

LROH:

127176608(pdgfc) 127177739(pdgfd)

GRF:	141285067(pdgfd) 141288570(pdgfc)

OMC:	131520569(pdgfd) 131553973(pdgfc)

PPRM:

120470677(pdgfd) 120474339(pdgfc)

RKG:	130072480(pdgfd) 130095149(pdgfc)

SCEP:

307167483(pdgfd) 307171311(pdgfc)

MAMB:

125248816(pdgfd) 125258960(pdgfc)

CIDE:

127494511 127495214

CERY:

137005314(pdgfd) 137014315(pdgfc)

MASI:

127412921 127418248 127422610 127429935

TROS:

130564190(pdgfc) 130565130(pdgfd)

TDW:	130429169(pdgfd) 130437562(pdgfc)

MANU:

129422922(pdgfc) 129438678(pdgfd)

PDAB:

135757812(pdgfc) 135770692(pdgfd)

IPU:	108269254 108277755

IFU:	128612076(pdgfc) 128621002(pdgfd)

PHYP:

113544462(pdgfd) 113547158(pdgfc)

SMEO:

124386574(pdgfc) 124394185(pdgfd)

TFD:	113637943(pdgfd) 113652952(pdgfc) 125145935

TVC:	132856179(pdgfc) 132858382(pdgfd)

CGAR:

128531326(pdgfc) 128533615(pdgfd)

NGRA:

132890400(pdgfc) 132900930(pdgfd)

TRN:	134318924(pdgfc) 134334732(pdgfd)

AMEX:

103040737(pdgfc) 103045444(pdgfd)

CMAO:

118798611(pdgfd) 118807284(pdgfc)

EEE:	113578705(pdgfd) 113582430(pdgfc)

CHAR:

105906158(pdgfc) 105909300(pdgfd)

SPIL:

134095782(pdgfc) 134099525(pdgfd)

ASAD:

121682034(pdgfc) 121684476(pdgfd)

TRU:	101062634(pdgfc) 101063213(pdgfd)

TFS:	130531528(pdgfc) 130535564(pdgfd)

TNG:	GSTEN00009365G001 GSTEN00024421G001

NCC:	104952384(pdgfc) 104961516(pdgfd)

TBEN:

117470228(pdgfd) 117490963(pdgfc)

CGOB:

115014680(pdgfc) 115017290(pdgfd)

PGEO:

117453372(pdgfc) 117457479(pdgfd)

GACU:

117552268(pdgfd) 117553616(pdgfc)

EMAC:

134860056(pdgfc) 134879772(pdgfd)

ELY:	117259313(pdgfd) 117260587(pdgfc)

EFO:	125888349(pdgfd) 125894041(pdgfc)

PLEP:

121943688(pdgfd) 121948201(pdgfc)

SLUC:

116048250(pdgfd) 116052917(pdgfc)

SVIT:

144524111(pdgfc)

ECRA:

117942180(pdgfd) 117952126(pdgfc)

ESP:	116683329(pdgfd) 116696522(pdgfc)

PFLV:

114549755(pdgfd) 114562955(pdgfc)

PFLT:

120566268(pdgfc)

GAT:	120818176(pdgfc) 120825608(pdgfd)

PPUG:

119210028(pdgfc) 119217110(pdgfd)

AFB:	129090242(pdgfc) 129092690(pdgfd)

CLUM:

117737233(pdgfc) 117741616(pdgfd)

PSWI:

130209766(pdgfc) 130211342(pdgfd)

CANA:

137790690(pdgfd) 137793006(pdgfc)

CVE:	137871710(pdgfd) 137875725(pdgfc)

MSAM:

119883119(pdgfd) 119889019(pdgfc)

SCHU:

122879451(pdgfd) 122880573(pdgfc)

EARM:

139285821(pdgfd) 139291581(pdgfc)

CUD:	121516138(pdgfc) 121521020(pdgfd)

SPUL:

138597077(pdgfd) 138598344(pdgfc)

LMIX:

132980322(pdgfd) 132981645(pdgfc)

HTC:	141793561(pdgfc) 141797457(pdgfd)

ALAT:

119007900(pdgfc) 119012997(pdgfd)

ASTR:

137596610(pdgfd) 137602672(pdgfc)

PKLU:

139200436(pdgfd) 139207291(pdgfc)

LCO:	104928604(pdgfc) 104929855(pdgfd)

AMMM:

307256376(pdgfc)

MZE:	101466155(pdgfc) 101473381(pdgfd)

ONL:	100700544(pdgfd) 100707883(pdgfc)

OAU:	116323003(pdgfd) 116334477(pdgfc)

OLA:	101159654(pdgfc) 101163754(pdgfd)

OML:	112139723(pdgfc) 112149011(pdgfd)

CSAI:

133441689(pdgfd) 133446800(pdgfc)

XMA:	102217846(pdgfc) 102220475(pdgfd)

XCO:	114139572(pdgfc) 114162009(pdgfd)

XHE:	116708226(pdgfd) 116714658(pdgfc)

PRET:

103471839(pdgfc) 103474493(pdgfd)

PFOR:

103137335(pdgfc) 103146257(pdgfd)

PLAI:

106947127(pdgfc) 106959838(pdgfd)

PMEI:

106914867(pdgfc) 106924883(pdgfd)

GAF:	122832700(pdgfd) 122837108(pdgfc)

PPRL:

129359460(pdgfd) 129360778 129360781

CVG:	107091713(pdgfc) 107100525(pdgfd)

CTUL:

119771773(pdgfd) 119772609(pdgfc)

GMU:	124859797(pdgfc) 124883537(pdgfd)

NFU:	107379856(pdgfc) 107380445(pdgfd)

KMR:	108236624(pdgfc) 108244637(pdgfd)

ALIM:

106513253(pdgfc) 106521430(pdgfd)

NWH:	119408746(pdgfc) 119411092(pdgfd)

LTU:	140314418(pdgfd) 140317740(pdgfc)

MCEP:

125007620(pdgfc) 125013002(pdgfd)

AOCE:

111572666(pdgfd) 111574994(pdgfc)

EJA:	138197236(pdgfd) 138211701(pdgfc)

BFRE:

138615439(pdgfd) 138622725(pdgfc)

LCF:	108885187 108886631

CSEM:

103378536(pdgfd) 103390671(pdgfc)

POV:	109634384(pdgfd) 109640033(pdgfc)

SSEN:

122773477(pdgfd) 122778939(pdgfc)

SSOE:

131463111(pdgfd) 131472063(pdgfc)

HHIP:

117769592(pdgfc) 117773035(pdgfd)

HSP:	118106220(pdgfd) 118112805(pdgfc)

PPLT:

128440575(pdgfd) 128446507(pdgfc)

SMAU:

118299818(pdgfd) 118319480(pdgfc)

SDU:	111224145(pdgfd) 111232625(pdgfc)

SLAL:

111648147(pdgfc) 111655272(pdgfd)

XGL:	120785845(pdgfc) 120792069(pdgfd)

HCQ:	109525495(pdgfd) 109526276(pdgfc)

SSCV:

125972264(pdgfd) 125979893(pdgfc)

SBIA:

133504502(pdgfd) 133508971(pdgfc)

PEE:	133404990(pdgfd) 133407885(pdgfc)

PTAO:

133482593(pdgfd) 133484834(pdgfc)

BPEC:

110153706(pdgfc) 110174393(pdgfd)

ENY:	140348639(pdgfc) 140375555(pdgfd)

MALB:

109964277(pdgfc) 109971615(pdgfd)

BSPL:

114864781(pdgfc) 114868399(pdgfd)

SJO:	128359961(pdgfd) 128363153(pdgfc)

SSCO:

133980746(pdgfd) 133986066(pdgfc)

TTY:	137185983(pdgfd) 137189820(pdgfc)

GMH:	115552752(pdgfc) 115561380(pdgfd)

SASA:

106581363 106604525(pdgfc) 106611576 106613208(pdgfd)

STRU:

115163701 115170724 115205109 115206602

OTW:	112221054 112236859(pdgfd) 112247795 112256335(pdgfc)

OMY:	110488931 110503174(pdgfd) 110505128(pdgfc) 110507975

OGO:	123993511 123994061 124006478(pdgfd) 124011420

ONE:	115119294(pdgfd) 115129551 115130813

OKI:	109883690(pdgfd) 109900111 109905280 109910061

OKE:	118363593 118373507 118379632 118394494(pdgfd)

OMM:	135526499 135545099 135545980 135551560

OCLA:

139366010 139382557 139386181 139390722 139399187

SALP:

111965835 111967581

SNH:	120047418(pdgfc) 120061873

SFON:

129827969 129832519(pdgfd) 129858258

CCLU:

121537098 121546234 121558055 121567801

ELS:	105024074(pdgfd) 105027646(pdgfc)

OEP:	134015608 134032901(pdgfc)

SFM:	108924448(pdgfc) 108930808 108932118(pdgfd)

PKI:	111833654 111833932(pdgfd) 111837344

AANG:

118209920(pdgfd) 118226720 118231375(pdgfc)

AROT:

135235698(pdgfd) 135254830 135259805(pdgfc)

CCOG:

133108704(pdgfd) 133131329 133135146

LOC:	102688904(pdgfc) 102694666(pdgfd)

PSPA:

121295227 121320343(pdgfd) 121322941

ARUT:

117407401 117408382 117420633 117964366 117972789

PSEX:

120523158(pdgfd) 120527165(pdgfc)

LCM:	102351685(PDGFD) 102356509(PDGFC)

CMK:	103182267(pdgfc) 103185765(pdgfd)

RTP:	109915080(pdgfd) 109938372(pdgfc)

CPLA:

122550691(pdgfd) 122559361(pdgfc)

CPUN:

140481392(pdgfd) 140485766(pdgfc)

HOC:	132816450(pdgfd) 132833271(pdgfc)

SCAU:

119963317(pdgfc) 119977361(pdgfd)

LERI:

129698144(pdgfd) 129703349(pdgfc)

HAKA:

140726521(pdgfc) 140726784(pdgfd)

» show all

Reference

PMID:11004490

Authors

Tsai YJ, Lee RK, Lin SP, Chen YH

Title

Identification of a novel platelet-derived growth factor-like gene, fallotein, in the human reproductive tract.

Journal

Biochim Biophys Acta 1492:196-202 (2000)
DOI:10.1016/S0167-4781(00)00066-X

Sequence

[hsa:56034]

Reference

PMID:15061151

Authors

Fang L, Yan Y, Komuves LG, Yonkovich S, Sullivan CM, Stringer B, Galbraith S, Lokker NA, Hwang SS, Nurden P, Phillips DR, Giese NA

Title

PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle.

Journal

Arterioscler Thromb Vasc Biol 24:787-92 (2004)
DOI:10.1161/01.ATV.0000120785.82268.8b

Sequence

[mmu:54635]

All links

Ontology (1)   
   GO (1)   
Gene (882)   
   MGENES (513)   
   RefGene (368)   
   OC (1)   
All databases (883)   

Download RDF

ORTHOLOGY: K05459

Entry

K05459                      KO

Symbol

IGF1

Name

insulin-like growth factor 1

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map01522

Endocrine resistance

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04066

HIF-1 signaling pathway

map04068

FoxO signaling pathway

map04081

Hormone signaling

map04114

Oocyte meiosis

map04115

p53 signaling pathway

map04150

mTOR signaling pathway

map04151

PI3K-Akt signaling pathway

map04152

AMPK signaling pathway

map04211

Longevity regulating pathway

map04213

Longevity regulating pathway - multiple species

map04510

Focal adhesion

map04518

Integrin signaling

map04550

Signaling pathways regulating pluripotency of stem cells

map04730

Long-term depression

map04750

Inflammatory mediator regulation of TRP channels

map04913

Ovarian steroidogenesis

map04914

Progesterone-mediated oocyte maturation

map04935

Growth hormone synthesis, secretion and action

map04960

Aldosterone-regulated sodium reabsorption

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05205

Proteoglycans in cancer

map05214

Glioma

map05215

Prostate cancer

map05218

Melanoma

map05224

Breast cancer

map05410

Hypertrophic cardiomyopathy

map05414

Dilated cardiomyopathy

Disease

H00015

Malignant pleural mesothelioma

H02040

Insulin-like growth factor I deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04014 Ras signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04015 Rap1 signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04066 HIF-1 signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04068 FoxO signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04151 PI3K-Akt signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04152 AMPK signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04150 mTOR signaling pathway
    K05459  IGF1; insulin-like growth factor 1
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    K05459  IGF1; insulin-like growth factor 1
   04518 Integrin signaling
    K05459  IGF1; insulin-like growth factor 1
09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K05459  IGF1; insulin-like growth factor 1
   04115 p53 signaling pathway
    K05459  IGF1; insulin-like growth factor 1
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05459  IGF1; insulin-like growth factor 1
   04550 Signaling pathways regulating pluripotency of stem cells
    K05459  IGF1; insulin-like growth factor 1
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K05459  IGF1; insulin-like growth factor 1
   04914 Progesterone-mediated oocyte maturation
    K05459  IGF1; insulin-like growth factor 1
   04935 Growth hormone synthesis, secretion and action
    K05459  IGF1; insulin-like growth factor 1
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K05459  IGF1; insulin-like growth factor 1
  09156 Nervous system
   04730 Long-term depression
    K05459  IGF1; insulin-like growth factor 1
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K05459  IGF1; insulin-like growth factor 1
  09149 Aging
   04211 Longevity regulating pathway
    K05459  IGF1; insulin-like growth factor 1
   04213 Longevity regulating pathway - multiple species
    K05459  IGF1; insulin-like growth factor 1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05459  IGF1; insulin-like growth factor 1
   05202 Transcriptional misregulation in cancer
    K05459  IGF1; insulin-like growth factor 1
   05205 Proteoglycans in cancer
    K05459  IGF1; insulin-like growth factor 1
  09162 Cancer: specific types
   05214 Glioma
    K05459  IGF1; insulin-like growth factor 1
   05218 Melanoma
    K05459  IGF1; insulin-like growth factor 1
   05215 Prostate cancer
    K05459  IGF1; insulin-like growth factor 1
   05224 Breast cancer
    K05459  IGF1; insulin-like growth factor 1
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K05459  IGF1; insulin-like growth factor 1
   05414 Dilated cardiomyopathy
    K05459  IGF1; insulin-like growth factor 1
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05459  IGF1; insulin-like growth factor 1
   01522 Endocrine resistance
    K05459  IGF1; insulin-like growth factor 1
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05459  IGF1; insulin-like growth factor 1
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Growth factors (RTK binding)
   K05459  IGF1; insulin-like growth factor 1

Other DBs

GO:

0005159

Genes

HSA:	3479(IGF1)

PTR:	741055(IGF1)

PPS:	100982978(IGF1)

GGO:	101154397(IGF1)

PON:	100444645(IGF1)

PPYG:

129010938(IGF1)

NLE:	100595306(IGF1)

HMH:	116478036(IGF1)

SSYN:

129459357(IGF1)

MCC:	698444(IGF1)

MCF:	102128018(IGF1)

MTHB:

126931779

MNI:	105493817(IGF1)

CSAB:

103238957(IGF1)

CATY:

105573305(IGF1)

PANU:

101010276(IGF1)

TGE:	112635504(IGF1)

MLEU:

105530906(IGF1)

RRO:	104657459(IGF1)

RBB:	108543134(IGF1)

TFN:	117089531(IGF1)

PTEH:

111523785(IGF1)

CANG:

105506748(IGF1)

CJC:	100394985(IGF1)

SBQ:	101036963(IGF1)

CIMI:

108294842(IGF1)

ANAN:

105728706(IGF1)

CSYR:

103264539(IGF1)

MMUR:

105875567(IGF1)

LCAT:

123639374(IGF1)

ERUF:

138397492(IGF1)

PCOQ:

105815122(IGF1)

OGA:	100951094(IGF1)

MMU:	16000(Igf1)

MCAL:

110304009(Igf1)

MPAH:

110326668(Igf1)

RNO:	24482(Igf1)

MCOC:

116076407(Igf1)

ANU:	143436043(Igf1)

ASYL:

127670511(Igf1)

MUN:	110561622(Igf1)

CGE:	100751642(Igf1)

MAUA:

101823090(Igf1)

PROB:

127237898(Igf1)

PLEU:

114700619(Igf1)

PMAV:

102916315(Igf1)

MORG:

121461353(Igf1)

MFOT:

126503857

AAMP:

119803277(Igf1)

CNL:	130866422(Igf1)

NGI:	103733723(Igf1)

HGL:	101707684(Igf1)

CPOC:

100135551(Igf1)

CCAN:

109677734 109697466(Igf1)

DORD:

105988510(Igf1)

DSP:	122119198(Igf1)

DMER:

138806022(Igf1)

PLOP:

125359379(Igf1)

NCAR:

124983128

SVUL:

306662500(IGF1)

MMMA:

107139962(Igf1)

ITI:	101968890(Igf1)

SCIL:

308658498(IGF1)

MAVE:

308269800(IGF1)

OCU:	100008668(IGF1)

OPI:	101526004(IGF1)

OCZ:	121159418(IGF1)

TUP:	102490248(IGF1)

GVR:	103601524(IGF1)

CFA:	610255(IGF1)

CLUD:

112654388(IGF1)

VVP:	112930717(IGF1)

VLG:	121481162(IGF1)

NPO:	129516962(IGF1)

AML:	100473254(IGF1)

UMR:	103676495(IGF1)

UAH:	113256079(IGF1)

UAR:	123780774(IGF1)

ELK:	111142036 111142293

LLV:

125106739

MPUF:

101680922(IGF1)

MNP:	132019316(IGF1)

MLK:	131839335(IGF1)

NVS:	122891725(IGF1)

MMAQ:

308347218(IGF1)

ORO:	101386334(IGF1)

EJU:	114222977(IGF1)

ZCA:	113922232(IGF1)

MLX:	117998812(IGF1)

MANO:

123843366(IGF1)

NSU:	110578055(IGF1)

LWW:	102728602(IGF1)

FCA:	101101237(IGF1)

PYU:	121040524(IGF1)

PCOO:

112863499(IGF1)

PBG:	122472604(IGF1)

PVIV:

125171123(IGF1)

LRUF:

124502456

LGF:	123590772(IGF1)

AJU:

106971906

PTG:	102962543(IGF1)

PPAD:

109265419(IGF1)

PUC:

125919488

PLEZ:

122225002(IGF1)

HHV:	120245431(IGF1)

CCRU:

144238373(IGF1)

BTA:	281239(IGF1)

BOM:	102272009(IGF1)

BIU:	109559448(IGF1)

BJV:	133247811(IGF1)

BBUB:

102392528(IGF1)

BKE:	129648700(IGF1)

BBIS:

104998318(IGF1)

CHX:	100860838(IGF1)

OAS:	443318(IGF1)

OCAN:

138437601(IGF1)

BTAX:

128048032(IGF1)

CSUM:

138077911(IGF1)

ODA:	120858659(IGF1)

CCAD:

122423293(IGF1)

MREE:

136169809(IGF1)

OVR:	110129456(IGF1)

MBEZ:

129535856(IGF1)

SSC:	397491(IGF1)

CFR:	102506236(IGF1)

CBAI:

105075052(IGF1)

CDK:	105097468(IGF1)

VPC:	102527219(IGF1)

BACU:

103014780(IGF1)

BMUS:

118901824(IGF1)

LVE:	103078928(IGF1)

OOR:	101269950(IGF1)

LALB:

132528728(IGF1)

GMF:	115852931(IGF1)

DDP:	132433994(IGF1)

SCOO:

307194789(IGF1)

PCRS:

137202335(IGF1)

DLE:	111187819(IGF1)

PCAD:

102990550(IGF1)

PSIU:

116760902(IGF1)

PPHC:

136130428(IGF1)

NASI:

112391070(IGF1)

HAMP:

307060759(IGF1)

ECB:	100034198(IGF1)

EPZ:	103549360(IGF1)

EAI:	106827264(IGF1)

MYB:	102252071(IGF1)

MYD:	102752580(IGF1)

MMYO:

118651145(IGF1)

MLF:	102424041(IGF1)

MDT:	132227107(IGF1)

MYUM:

139007459(IGF1)

PKL:	118729152(IGF1)

EFUS:

103288953(IGF1)

POTS:

308243958(IGF1)

MNA:	107545147(IGF1)

DRO:	112321846(IGF1)

SHON:

119002367(IGF1)

AJM:	119060308(IGF1)

PDIC:

114513472(IGF1)

PHAS:

123810596(IGF1)

MMF:	118624040(IGF1)

PPAM:

129071377(IGF1)

HAI:	109387785(IGF1)

RFQ:	117028523(IGF1)

RHII:

308502349(IGF1)

PALE:

102890331(IGF1)

PGIG:

120614955(IGF1)

PVP:	105310714(IGF1)

RAY:	107501166(IGF1)

MJV:	108410340(IGF1)

TOD:	119247369(IGF1)

SARA:

101554190(IGF1)

SFUM:

130026854(IGF1)

SETR:

126022310(IGF1)

LAV:	100664710(IGF1)

TMU:

101361934

ETF:	101644114(IGF1)

DNM:	101440893(IGF1)

MDO:	100021295(IGF1)

GAS:	123250427(IGF1)

SHR:	100918816(IGF1)

AFZ:

127537871

PCW:	110205653(IGF1)

TVP:	118849915(IGF1)

PBRV:

138166749(IGF1)

MLAO:

141515280(IGF1)

OAA:	100075905(IGF1)

TACU:

119937123(IGF1)

GGA:	418090(IGF1)

MGP:	104911603 678666

CJO:	107316281(IGF1)

TPAI:

128073537(IGF1)

LMUT:

125700329(IGF1)

NMEL:

110393921(IGF1)

APLA:

101793597(IGF1)

AACU:

137846229(IGF1)

OJA:	118175517(IGF1)

BCLA:

308442049(IGF1)

ACYG:

106035916(IGF1)

ABRC:

308179233(IGF1)

CATA:

118256041(IGF1)

AFUL:

116494460(IGF1)

TGU:	100226283(IGF1)

LSR:	110473651(IGF1)

VMC:	128807366(IGF1)

VCHA:

128787861(IGF1)

AIB:	137474412(IGF1)

SCAN:

103819655(IGF1)

PMOA:

120501703(IGF1)

OTC:	121332824(IGF1)

PRUF:

121363553(IGF1)

ATRC:

139587791(IGF1)

MATE:

118698030(IGF1)

MAEN:

136556755(IGF1)

GFR:	102032215(IGF1)

FAB:	101808710(IGF1)

OMA:	130248238(IGF1)

PHI:	102112946(IGF1)

PMAJ:

107204610(IGF1)

CCAE:

111936136(IGF1)

CCW:	104696228(IGF1)

CBRC:

103618021(IGF1)

ACOE:

138104157(IGF1)

ETL:	114056148(IGF1)

ZAB:	102063644(IGF1)

ZLE:	135460307(IGF1)

ACHL:

103804378(IGF1)

SVG:	106853619(IGF1)

MMEA:

130585967

HRT:	120752390(IGF1)

SATI:

136361787(IGF1)

CFAI:

136289790(IGF1)

CCIC:

134043150(IGF1)

NNT:	104412813(IGF1)

SHAB:

115605695(IGF1)

POCC:

134162492(IGF1)

FPG:	101922655(IGF1)

FCH:	102060062(IGF1)

FRS:	119148611(IGF1)

CCRI:

104167799(IGF1)

ACUN:

113491340(IGF1)

ANOC:

141958926(IGF1)

SURA:

141943825(IGF1)

TALA:

104357403(IGF1)

ACHC:

115352695(IGF1)

HALD:

104314428(IGF1)

HLE:	104831000(IGF1)

AGEN:

126048035

HHAR:

128143327(IGF1)

BBUT:

142041781(IGF1)

GCL:

127023592

CSTI:

104553487(IGF1)

LDI:	104352212(IGF1)

MNB:	103778013(IGF1)

DPUB:

104296561(IGF1)

PPUS:

135181930(IGF1)

IIN:	128971192(IGF1)

AVIT:

104277162(IGF1)

BRHI:

104499498(IGF1)

EGZ:	104135582(IGF1)

NNI:	104013358(IGF1)

PCRI:

104034140(IGF1)

PCAO:

104041892(IGF1)

PARX:

142048260(IGF1)

PADL:

103924427(IGF1)

AFOR:

103906465(IGF1)

FGA:	104078514(IGF1)

CBOR:

142087541(IGF1)

GSTE:

104256042 104258565

CBOY:

140646099(IGF1)

MAME:

142410347(IGF1)

CLV:	102092089(IGF1)

CNIC:

135996768(IGF1)

NMAY:

308052795(IGF1)

MUI:	104538977(IGF1)

PGUU:

104463631(IGF1)

PLET:

104620835(IGF1)

EHS:	104507576 104515844(IGF1)

CMAC:

104477534(IGF1)

CUCA:

104058924(IGF1)

PCUR:

138721885(IGF1)

TEO:	104373406(IGF1)

BREG:

104631537(IGF1)

GAME:

129196243(IGF1)

OHA:	104338273(IGF1)

ACAR:

104527736(IGF1)

CEUR:

306719038(IGF1)

CPEA:

104396024(IGF1)

CVF:	104288591(IGF1)

RTD:	128913956(IGF1)

CRID:

134508718(IGF1)

LMIC:

141741271(IGF1)

NARQ:

141478056(IGF1)

AAM:	106488383(IGF1)

AROW:

112974679(IGF1)

NPD:	112946628(IGF1)

TGT:	104579065(IGF1)

DNE:	112993900(IGF1)

SCAM:

104147350(IGF1)

ASN:	102372626(IGF1)

AMJ:	102559209(IGF1)

CPOO:

109316558(IGF1)

GGN:	109296127(IGF1)

PSS:	102454948(IGF1)

CIZ:	142007244(IGF1)

CMY:	102932263(IGF1)

CCAY:

125627421(IGF1)

LKP:	140902894(IGF1)

NDS:	141978470(IGF1)

DCC:	119863689(IGF1)

CPIC:

101939474(IGF1)

TST:	117881442(IGF1)

EOB:	135887137(IGF1)

CABI:

116835804(IGF1)

MRV:	120372555(IGF1)

EMQ:	137145439(IGF1)

ACS:	100566682(igf1)

ASAO:

132775850(IGF1)

PVT:	110084792(IGF1)

SUND:

121931902(IGF1)

PBI:	103062109(IGF1)

PMUR:

107289460(IGF1)

CTIG:

120305865(IGF1)

TSR:	106542973 106543552

PGUT:

117655505(IGF1)

PCAE:

139319007(IGF1)

APRI:

131202458(IGF1)

PTEX:

113455259(IGF1)

NSS:	113432811(IGF1)

VKO:	123028864(IGF1)

PMUA:

114605733(IGF1)

PRAF:

128422248(IGF1)

ZVI:	118091403(IGF1)

HCG:	128328058(IGF1)

GJA:	107119991(IGF1)

STOW:

125435887(IGF1)

EMC:	129335654(IGF1)

XLA:	108711020(igf1.S) 108712492

XTR:	100486334(igf1)

NPR:	108789614(IGF1)

RTEM:

120932128(IGF1)

ACAT:

141132197(IGF1)

PADS:

140323785(IGF1)

BBUF:

120979169(IGF1)

BGAR:

122928101(IGF1)

DTC:	141088927(IGF1)

HSQ:	130367020(IGF1)

PCOB:

134932933(IGF1)

PWL:	138287946(IGF1)

MUO:	115477599(IGF1)

GSH:	117363927(IGF1)

DRE:	114433(igf1)

DAES:

130223025(igf1)

SRX:	107725558 107744912 107755307

SANH:

107659835 107664880 107665064

SGH:	107587753(igf1) 107590124 107598996

CCAR:

109063573 109068761 109077376(igf1) 109077408

CAUA:

113048037 113062844 113093578 113107926

CGIB:

127956905

PTET:

122343405(igf1)

LROH:

127164105(igf1)

GRF:	141333701(igf1)

OMC:	131539332(igf1)

PPRM:

120477039(igf1)

RKG:	130072306(igf1)

SCEP:

307158073(igf1)

MAMB:

125245042(igf1)

CIDE:

127511009

CERY:

137024432(igf1)

MASI:

127435475 127436645

TROS:

130548164(igf1)

TDW:	130420580(igf1)

MANU:

129432217(igf1)

PDAB:

135774869(igf1)

IPU:	100305062(igf1)

IFU:	128623736(igf1)

PHYP:

113532358(igf1) 113535157

SMEO:

124401481(igf1)

TFD:	113651580(igf1)

TVC:	132859079(igf1)

CGAR:

128534173(igf1)

NGRA:

132869919(igf1)

TRN:	134314789(igf1)

AMEX:

103036238(igf1)

CMAO:

118812612(igf1)

EEE:	113584584(igf1)

CHAR:

105902602(igf1)

SPIL:

134061915(igf1)

TRU:	100462939(igf1)

TFS:	130519173(igf1)

TNG:	GSTEN00023793G001

NCC:	104943645 104956990

TBEN:

117485067(igf1) 117494701

CGOB:

115020429 115028254(igf1)

PGEO:

117439185(igf1) 117448931

GACU:

117547681 117552476(igf1)

EMAC:

134879206(igf1) 134881571(igf3)

ELY:	117248938(igf1) 117258901(igf3)

EFO:	125882923(igf1) 125892050(igf3)

PLEP:

121947581(igf3) 121961360(igf1)

SLUC:

116058699(igf3) 116060060(igf1)

SVIT:

144512272(igf1)

ECRA:

117938750(igf1)

ESP:	116673369(igf1) 116691938

PFLV:

114549943(igf1) 114559177

PFLT:

120553251(igf1)

GAT:	120818080(igf1)

PPUG:

119199433(igf3) 119210507(igf1)

AFB:	129100310(igf3) 129112224(igf1)

CLUM:

117726064(igf1) 117733820(igf3)

PSWI:

130200048 130200517(igf1) 130212676 130213272 130213274 130213275 130213282

CANA:

137791356(igf1) 137801026(igf3)

TBU:	306752679(igf1)

CVE:	137877359(igf1) 137889386(igf3)

MSAM:

119905971 119917907(igf1)

SCHU:

122871522(igf1) 122883752(igf3)

EARM:

139289411(igf3) 139305110(igf1)

CUD:	121505327(igf1) 121517695

SPUL:

138590386(igf3) 138599191(igf1)

LMIX:

132956174(igf1) 132989691(igf3)

HTC:	141810609(igf1)

ALAT:

119022093 119032208(igf1)

ASTR:

137589144(igf1) 137613830(igf3)

PKLU:

139209340(igf3) 139221578(igf1)

LCO:	104926290(igf1) 104935275

AMMM:

307268254(igf1)

MZE:	101476517(igf1)

ONL:	100534428 100534565(igf1)

OAU:	116315126 116325442(igf1)

OLA:	101168167(igf1) 105354483

OML:	112157480(igf1) 112158927

CSAI:

133424382(igf1) 133456311(igf3)

XMA:	102221578 102222602(igf1)

XCO:	114142519 114160998(igf1)

XHE:	116721459 116737032(igf1)

PRET:

103459389(igf1) 103466958(igf3)

PFOR:

103140256(igf1) 103155310

PLAI:

106949561 106960769(igf1)

PMEI:

106924487 106925431(igf1)

GAF:	122826246(igf1) 122847244(igf3)

PPRL:

129351491(igf1) 129371864(igf3)

CVG:	107085823(igf1) 107097451

CTUL:

119776605(igf3) 119781054(igf1)

GMU:	124876646(igf3) 124883008(igf1)

NFU:	107386743(igf1) 107391385

KMR:	108228312 108233311(igf1)

ALIM:

106529338 106530265(igf1)

NWH:	119428082(igf1)

LTU:	140271683(igf3) 140282715(igf1)

MCEP:

124998181(igf3) 125000330(igf1)

AOCE:

111568767(igf1) 111587489(igf3)

EJA:	138192089(igf3) 138192445(igf1)

BFRE:

138622000(igf1) 138637134(igf3)

LCF:	108897582 108900498(igf3)

CSEM:

103382578(igf1) 103384875

POV:	109639654 109640767(igf1)

SSEN:

122766078(igf1) 122776793

SSOE:

131457116(igf1) 131468119

HHIP:

117757155(igf1) 117765172

HSP:	118101635(igf1) 118110683(igf3)

PPLT:

128428555(igf1) 128442789

SMAU:

118290655(igf1) 118316472

SDU:	111225018(igf1) 111233786

SLAL:

111658878 111664700(igf1)

XGL:	120800043(igf1) 120804563(igf3)

HCQ:	109528351 109530129(igf1)

SSCV:

125988137(igf3) 125992306(igf1)

SBIA:

133493576(igf1) 133512077(igf3)

PEE:	133397194(igf1) 133415074(igf3)

PTAO:

133472083(igf1) 133486846(igf3)

BPEC:

110159406 110161867(igf1) 110172781

ENY:	140367407(igf1)

MALB:

109967822(igf1) 109971005

BSPL:

114850808 114858699(igf3) 114862460(igf1) 114864489

SJO:	128353374(igf1) 128357012(igf3)

SSCO:

133987233(igf3)

TTY:	137175740(igf1) 137183966(igf3)

GMH:	115541483(igf1) 115541525

SASA:

100136517 106609475

STRU:

115180501 115198940

OTW:	112214206 112217005

OMY:	100136741 110500054(igf1)

OGO:	123994489 124013790(igf1)

ONE:	115107064 115133034

OKI:	109896659(igf1) 109896674

OKE:	118366328 118392473

OMM:	135514959 135515840 135533687

OCLA:

139378555 139393311

SALP:

111951443 111982846

SNH:	120031740 120049944

SFON:

129838939 129865010

CCLU:

121548967 121578998

ELS:	105030158(igf1)

OEP:	134037448(igf1)

SFM:	108931632(igf1) 114909159

PKI:	111834375 111846569(igf1)

AANG:

118219087 118232412(igf1)

AROT:

135246104 135259185(igf1)

CCOG:

133119349 133134953(igf1)

LOC:	102694945(igf1)

PSPA:

121300243 121300319 121318433(igf1) 121319666

ARUT:

117414927 117419510

PSEX:

120534262(igf1)

LCM:	102361051(IGF1) 102365620

CMK:	103179868(igf1)

RTP:	109914145(igf1)

CPLA:

122559407(igf1)

CPUN:

140458037(igf1)

HOC:	132824606(igf1)

SCAU:

119955181(igf1)

LERI:

129706324(igf1) 129708784

HAKA:

140734972(igf1)

BFO:

118407319

CIN:	100170003(ins-l1)

ARUN:

117291630

AAMU:

139939688

DME:	Dmel_CG14049(Ilp6)

DER:

6555537

DSE:

6616142

DSI:	Dsimw501_GD28130(Dsim_GD28130)

DYA:	Dyak_GE10998

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI21443

DAZ:

DNV:

DHE:

MDE:

LCQ:

LSQ:

CVJ:

BMOR:

100147697(Bbx-c2) 100169656(Bbx-b11) 100169707(Bbx-a10) 100169715(Bbx-b10) 100169718(Bbx-b8) 100169722(Bbx-b3) 100270769(Igflp)

BMAN:

114249644 114249651 114249652 114252207 114252208 114252226 114252227 114252284 114252557

HAW:	110375556 135117472

TNL:

SLIU:

TCA:

TMOL:

HAXR:

ACER:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BPYO:

FVI:

CCAL:

OBB:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

VEM:

HST:

DQU:

CFO:

FEX:

OBO:

PFUC:

VPS:

VCRB:

NVI:

LBD:	127278092 127280644

FAS:

DAM:

AGIF:

CCIN:

API:

RMD:	113557434 113559997 113560211

CLEC:

FOC:

TPAL:

CSEC:

BROR:

PVUL:

HRF:

HCRA:

MAEA:

LJP:

SMM:	Smp_151640

SHX:	MS3_00009920

NVE:

5512419

SPIS:

111342911

» show all

Reference

PMID:3002851

Authors

de Pagter-Holthuizen P, van Schaik FM, Verduijn GM, van Ommen GJ, Bouma BN, Jansen M, Sussenbach JS

Title

Organization of the human genes for insulin-like growth factors I and II.

Journal

FEBS Lett 195:179-84 (1986)
DOI:10.1016/0014-5793(86)80156-9

Sequence

[hsa:3479]

Reference

PMID:21076856

Authors

Zoidis E, Ghirlanda-Keller C, Schmid C

Title

Stimulation of glucose transport in osteoblastic cells by parathyroid hormone and insulin-like growth factor I.

Journal

Mol Cell Biochem 348:33-42 (2011)
DOI:10.1007/s11010-010-0634-z

Sequence

[hsa:3479]

All links

Ontology (1)   
   GO (1)   
Gene (87)   
   MGENES (45)   
   RefGene (33)   
   OC (9)   
All databases (88)   

Download RDF

ORTHOLOGY: K08774

Entry

K08774                      KO

Symbol

TGFA

Name

transforming growth factor, alpha

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map04010

MAPK signaling pathway

map04012

ErbB signaling pathway

map04014

Ras signaling pathway

map04020

Calcium signaling pathway

map04151

PI3K-Akt signaling pathway

map04915

Estrogen signaling pathway

map05200

Pathways in cancer

map05210

Colorectal cancer

map05211

Renal cell carcinoma

map05212

Pancreatic cancer

map05214

Glioma

map05215

Prostate cancer

map05223

Non-small cell lung cancer

map05225

Hepatocellular carcinoma

Disease

H00020

Colorectal cancer

H00048

Hepatocellular carcinoma

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K08774  TGFA; transforming growth factor, alpha
   04012 ErbB signaling pathway
    K08774  TGFA; transforming growth factor, alpha
   04014 Ras signaling pathway
    K08774  TGFA; transforming growth factor, alpha
   04020 Calcium signaling pathway
    K08774  TGFA; transforming growth factor, alpha
   04151 PI3K-Akt signaling pathway
    K08774  TGFA; transforming growth factor, alpha
09150 Organismal Systems
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K08774  TGFA; transforming growth factor, alpha
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08774  TGFA; transforming growth factor, alpha
  09162 Cancer: specific types
   05210 Colorectal cancer
    K08774  TGFA; transforming growth factor, alpha
   05212 Pancreatic cancer
    K08774  TGFA; transforming growth factor, alpha
   05225 Hepatocellular carcinoma
    K08774  TGFA; transforming growth factor, alpha
   05214 Glioma
    K08774  TGFA; transforming growth factor, alpha
   05211 Renal cell carcinoma
    K08774  TGFA; transforming growth factor, alpha
   05215 Prostate cancer
    K08774  TGFA; transforming growth factor, alpha
   05223 Non-small cell lung cancer
    K08774  TGFA; transforming growth factor, alpha
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K08774  TGFA; transforming growth factor, alpha
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K08774  TGFA; transforming growth factor, alpha
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Growth factors (RTK binding)
   K08774  TGFA; transforming growth factor, alpha

Other DBs

GO:

0005155

Genes

HSA:	7039(TGFA)

PTR:	737080(TGFA)

PPS:	100973153(TGFA)

GGO:	101140326(TGFA)

PON:	100172994(TGFA)

PPYG:

129030679(TGFA)

NLE:	100607585(TGFA)

HMH:	116483502(TGFA)

SSYN:

129462517(TGFA)

MCC:	613031(TGFA)

MCF:	102145541(TGFA)

MTHB:

126934085

MNI:	105465222(TGFA)

CSAB:

103220091(TGFA)

CATY:

105576539(TGFA)

PANU:

101023802(TGFA)

TGE:	112604653(TGFA)

MLEU:

105529939(TGFA)

RRO:	104661322(TGFA)

RBB:	108524582(TGFA)

TFN:	117061979(TGFA)

PTEH:

111550529(TGFA)

CANG:

105514084(TGFA)

CJC:	100402888(TGFA)

SBQ:	101045311(TGFA)

CIMI:

108299641(TGFA)

ANAN:

105733332(TGFA)

MMUR:

105863259(TGFA)

LCAT:

123637024(TGFA)

PCOQ:

105812073(TGFA)

OGA:	100959235(TGFA)

MMU:	21802(Tgfa)

MCAL:

110295684(Tgfa)

MPAH:

110316577(Tgfa)

RNO:	24827(Tgfa)

MCOC:

116099176(Tgfa)

ANU:	117715660(Tgfa)

ASYL:

127678044(Tgfa)

MUN:	110547163(Tgfa)

CGE:	100754730(Tgfa)

MAUA:

101823727(Tgfa)

PROB:

127214725(Tgfa)

PLEU:

114680857(Tgfa)

PMAV:

102922277(Tgfa)

MORG:

121435991(Tgfa)

MFOT:

126515578

AAMP:

119807169(Tgfa)

CNL:	130884462(Tgfa)

NGI:	103725901(Tgfa)

HGL:	101723712(Tgfa)

CCAN:

109701504(Tgfa)

DORD:

105990143(Tgfa)

DSP:	122125176(Tgfa)

DMER:

138804594(Tgfa)

PLOP:

125356867(Tgfa)

NCAR:

124962678

SVUL:

306644191(TGFA)

MMMA:

107137192(Tgfa)

ITI:	101969278(Tgfa)

SCIL:

308632676(TGFA)

OCU:

100009482

OCZ:	121164886(TGFA)

TUP:	102497817(TGFA)

GVR:	103603040(TGFA)

CFA:	403431(TGFA)

CLUD:

112674472(TGFA)

VLG:	121490441(TGFA)

NPO:	129511504(TGFA)

AML:	100467724(TGFA)

UMR:	103671814(TGFA)

UAH:	113268295(TGFA)

UAR:	123786035(TGFA)

ELK:

111148116

MPUF:

101690038(TGFA)

MNP:	132021470(TGFA)

MLK:	131840269(TGFA)

NVS:	122915444(TGFA)

MMAQ:

308349113(TGFA)

ORO:	101384783(TGFA)

EJU:	114218919(TGFA)

ZCA:	113938191(TGFA)

MLX:	118007998(TGFA)

MANO:

123850770(TGFA)

NSU:	110588715(TGFA)

LWW:	102738528(TGFA)

FCA:	101094921(TGFA)

PYU:	121019131(TGFA)

PCOO:

112869672(TGFA)

PBG:	122496971(TGFA)

PVIV:

125162665(TGFA)

LRUF:

124503927

LGF:	123580923(TGFA)

AJU:

106967765

PTG:	102956554(TGFA)

PPAD:

109262472(TGFA)

PUC:

125937079

PLEZ:

122216172(TGFA)

HHV:	120236624(TGFA)

CCRU:

144233432(TGFA)

BTA:	540388(TGFA)

BOM:	102264981(TGFA)

BIU:	109565956(TGFA)

BJV:	133256856(TGFA)

BBUB:

102406217(TGFA)

BKE:	129622890(TGFA)

BBIS:

104980934(TGFA)

CHX:	102185926(TGFA)

OAS:	101106508(TGFA)

OCAN:

138437073(TGFA)

BTAX:

128055664(TGFA)

CSUM:

138075431(TGFA)

ODA:	120851642(TGFA)

CCAD:

122441530(TGFA)

MREE:

136164483(TGFA)

OVR:	110149459(TGFA)

MBEZ:

129539010(TGFA)

SSC:	397484(TGFA)

CFR:	102506694(TGFA)

CBAI:

105075786(TGFA)

CDK:	105088937(TGFA)

VPC:	102525265(TGFA)

BACU:

103010563(TGFA)

BMUS:

118906348(TGFA)

LVE:	103076982(TGFA)

OOR:	101281424(TGFA)

LALB:

132531253(TGFA)

GMF:	115864085(TGFA)

DDP:	132435396(TGFA)

SCOO:

307196521(TGFA)

PCRS:

137206123(TGFA)

DLE:	111167945(TGFA)

PCAD:

102973542(TGFA)

PSIU:

116764662(TGFA)

PPHC:

136133771(TGFA)

NASI:

112407200(TGFA)

ECB:	100060423(TGFA)

EPZ:	103547583(TGFA)

EAI:	106828311(TGFA)

MYB:	102262078(TGFA)

MYD:	102768972(TGFA)

MMYO:

118668883(TGFA)

MLF:	102434624(TGFA)

MDT:	132213237(TGFA)

MYUM:

139019449(TGFA)

PKL:	118717499(TGFA)

EFUS:

103291446(TGFA)

POTS:

308256219(TGFA)

DRO:	112303034(TGFA)

SHON:

118988493(TGFA)

AJM:	119035804(TGFA)

PDIC:

114498679(TGFA)

PHAS:

123811931(TGFA)

MMF:	118630701(TGFA)

PPAM:

129081363(TGFA)

HAI:	109385384(TGFA)

RFQ:	117033382(TGFA)

RHII:

308505940(TGFA)

PALE:

102887662(TGFA)

PGIG:

120594411(TGFA)

PVP:	105295757(TGFA)

RAY:	107519111(TGFA)

MJV:	108388206(TGFA)

TOD:	119258571(TGFA)

SARA:

101553872(TGFA)

SFUM:

130035079(TGFA)

SETR:

126024677(TGFA)

LAV:	100665332(TGFA)

TMU:

101355918

ETF:	101659761(TGFA)

DNM:	101418598(TGFA)

MDO:	100032790(TGFA)

SHR:	100928770(TGFA)

PCW:	110207627(TGFA)

TVP:	118843298(TGFA)

PBRV:

138146801(TGFA)

MLAO:

141503061(TGFA)

OAA:	100090413(TGFA)

TACU:

119928651(TGFA)

GGA:	414743(TGFA)

PCOC:

116231314(TGFA)

MGP:	100542303(TGFA)

CJO:	107323712(TGFA)

TPAI:

128090190(TGFA)

LMUT:

125685318(TGFA)

NMEL:

110387213(TGFA)

APLA:

119713550(TGFA)

AACU:

137845340(TGFA)

OJA:	118177371(TGFA)

CATA:

118256047(TGFA)

AFUL:

116499458(TGFA)

TGU:	100222335(TGFA)

LSR:	110478619(TGFA)

VMC:	128820024(TGFA)

VCHA:

128800984(TGFA)

PMOA:

120499158(TGFA)

OTC:	121334122(TGFA)

PRUF:

121353986(TGFA)

ATRC:

139585191(TGFA)

MATE:

118695236(TGFA)

MAEN:

136567618(TGFA)

GFR:

102032034

OMA:	130261967(TGFA)

PHI:	102109017(TGFA)

CCAE:

111938749(TGFA)

CCW:	120411177(TGFA)

CBRC:

103624969(TGFA)

ACOE:

138121660(TGFA)

ETL:	114066430(TGFA)

ZAB:	102067692(TGFA)

ZLE:	135456957(TGFA)

ACHL:

103808491(TGFA)

HRT:	120763953(TGFA)

SATI:

136372446(TGFA)

CCIC:

134054784(TGFA)

NNT:	104402574(TGFA)

SHAB:

115618540(TGFA)

FPG:	101917220(SNRPG)

FCH:	102057058(TGFA)

FRS:	119140456(TGFA)

ANOC:

141971313(TGFA)

SURA:

141935682(TGFA)

ACHC:

115350364(TGFA)

AGEN:

126051696

HHAR:

128150334(TGFA)

BBUT:

142037649(TGFA)

GCL:

127025252

CSTI:

104552470(TGFA)

MNB:	103775715(TGFA)

DPUB:

104310146(TGFA)

PPUS:

135192501(TGFA)

PARX:

142048055(TGFA)

CBOR:

142093660(TGFA)

CBOY:

140643972(TGFA)

MAME:

142420108(TGFA)

CLV:	102097060(TGFA)

CNIC:

135998543(TGFA)

CUCA:

104061134(TGFA)

GAME:

129196796(TGFA)

ACAR:

104520107(TGFA)

CPEA:

104386411(TGFA)

CRID:

134526602(TGFA)

LMIC:

141733369(TGFA)

AAM:	106490250(TGFA)

AROW:

112973627(TGFA)

NPD:	112949776(TGFA)

TGT:	104571455(TGFA)

DNE:	112996701(TGFA)

ASN:	102379226(TGFA)

AMJ:	102570675(TGFA)

PSS:	102445585(TGFA)

CIZ:	142004193(TGFA)

CMY:	102947389(TGFA)

CCAY:

125626357(TGFA)

LKP:	140903503(TGFA)

NDS:	141978159(TGFA)

DCC:	119848797(TGFA)

CPIC:

101939693(TGFA)

TST:	117872910(TGFA)

EOB:	135874761(TGFA)

CABI:

116816012(TGFA)

MRV:	120399018(TGFA)

EMQ:	137142876(TGFA)

ASAO:

132782524(TGFA)

PVT:	110072211(TGFA)

SUND:

121932956(TGFA)

PBI:	103053928(TGFA)

PMUR:

107283236(TGFA)

CTIG:

120299367(TGFA)

TSR:	106542615(TGFA)

PGUT:

117673346(TGFA)

APRI:

131204009(TGFA)

PTEX:

113445878(TGFA)

NSS:	113423376(TGFA)

VKO:	123016830(TGFA)

PMUA:

114602973(TGFA)

PRAF:

128420048(TGFA)

ZVI:	118087372(TGFA)

GJA:	107118762(TGFA)

STOW:

125442211(TGFA)

EMC:	129342667(TGFA)

XLA:	108696277(XB5893022.L) 108712769(tgfa.S) 496037(tgfa.L)

XTR:	100485434(tgfa) 733728

NPR:	108785348(TGFA) 108802996

RTEM:

120908962 120932973(TGFA)

ACAT:

141106712 141132972(TGFA)

PADS:

140324726(TGFA) 140325524 140339561

BBUF:

120986093(TGFA)

BGAR:

122929514(TGFA) 122944437

DTC:	141084385(TGFA) 141088713

PWL:	138265969(TGFA) 138302123

MUO:	115469349(TGFA) 115471193

GSH:	117359835 117363177(TGFA)

DRE:	100034402(tgfA)

DAES:

130230172(tgfa)

SRX:	107712107 107721172

SANH:

107673582 107673622

SGH:	107568177(tgfa)

CCAR:

109076240(tgfa) 109091017

CAUA:

113050427 113095282

CGIB:

127959516 128015799

PTET:

122347565(tgfa)

LROH:

127166375(tgfa)

GRF:	141347199(tgfa)

OMC:	131541840(tgfa)

PPRM:

120491630(tgfa)

RKG:	130087482(tgfa)

SCEP:

307166360(tgfa)

MAMB:

125273800(tgfa)

CIDE:

127514085

CERY:

137011258(tgfa)

MASI:

127446110 127449132

TROS:

130557359(tgfa)

TDW:	130425354(tgfa)

MANU:

129450994(tgfa)

PDAB:

135770170(tgfa)

IPU:	108271731(tgfa)

IFU:	128614915(tgfa)

PHYP:

113533017

SMEO:

124390412(tgfa)

TFD:	113642824(tgfa)

TVC:	132844463(tgfa)

CGAR:

128526938(tgfa)

NGRA:

132884608(tgfa)

TRN:	134317320(tgfa)

AMEX:

103044858(tgfa)

CMAO:

118808331(tgfa)

EEE:

113575949

CHAR:

105889175 122132925(tgfa)

SPIL:

134092227(tgfa)

ASAD:

121706613(tgfa)

TRU:	101076984(tgfa)

TFS:	130524163(tgfa)

TNG:	GSTEN00027441G001

NCC:	104955540(tgfa)

TBEN:

117489355(tgfa)

CGOB:

115007757

PGEO:

117447072(tgfa)

GACU:

117548226(tgfa)

EMAC:

134882375(tgfa)

ELY:	117256790(tgfa)

EFO:	125894296(tgfa)

PLEP:

121958095(tgfa)

SLUC:

116041613(tgfa)

ECRA:

117943608(tgfa)

ESP:

116688024

PFLV:

114554686(tgfa)

GAT:	120834900(tgfa)

PPUG:

119194324(tgfa)

AFB:	129106120(tgfa)

CLUM:

117730534(tgfa)

PSWI:

130208082(tgfa)

CANA:

137796851(tgfa)

CVE:	137873486(tgfa)

MSAM:

119884981 119886804(tgfa)

SCHU:

122863522(tgfa)

EARM:

139283180(tgfa)

CUD:	121504129(tgfa)

SPUL:

138606119(tgfa)

LMIX:

132977974(tgfa)

HTC:	141794328(tgfa)

ALAT:

119021253(tgfa)

ASTR:

137595525(tgfa)

PKLU:

139210610(tgfa)

LCO:

104931327

MZE:	101486967(tgfa)

ONL:	100706829(tgfa)

OAU:	116334242(tgfa)

OLA:

101166855

OML:	112144907(tgfa)

CSAI:

133449374(tgfa)

XMA:	102232831(tgfa)

XCO:

114134863

XHE:

116709713

PRET:

103464582(tgfa)

PFOR:

103137656(tgfa)

PLAI:

106953560(tgfa)

PMEI:

106914913(tgfa)

GAF:	122833553(tgfa)

PPRL:

129358454(tgfa)

CVG:

107101915

CTUL:

119784364(tgfa)

GMU:	124856394(tgfa)

NFU:

107385163

KMR:	108231156(tgfa)

ALIM:

106516091(tgfa)

NWH:	119412749(tgfa)

LTU:	140304012(tgfa)

MCEP:

125007356(tgfA)

AOCE:

111575277(tgfa)

EJA:	138199733(tgfa)

BFRE:

138616335(tgfa)

LCF:	108889336(tgfa)

CSEM:

103385772

POV:

109638459

SSEN:

122768083(tgfa)

SSOE:

131460529(tgfa)

HHIP:

117761975(tgfa)

HSP:	118102353(tgfa)

PPLT:

128461191(tgfa)

SMAU:

118310120(tgfa)

SDU:

111222913

SLAL:

111660748(tgfa)

XGL:	120806941(tgfa)

HCQ:	109531425(tgfa)

SSCV:

125977125(tgfa)

SBIA:

133507407(tgfa)

PEE:	133408919(tgfa)

PTAO:

133483544(tgfa)

BPEC:

110168760

ENY:	140365757(tgfa)

MALB:

109958999

BSPL:

114856313(tgfa)

SJO:	128355279(tgfa)

SSCO:

134006076(tgfa)

TTY:	137181455(tgfa)

GMH:	115547407(tgfa)

SASA:

106565349 106583550

STRU:

115150355(tgfa) 115208075

OTW:	112215181 112254807

OMY:	110494101 110528319

OGO:	124004036 124019218

ONE:	115142070 115143670

OKI:	109891268 109901499

OKE:	118388782 118400480

OMM:	135538888 135541741(tgfa)

OCLA:

139369437 139414398

SALP:

111963590 111970297

SNH:	120021555 120064795(tgfa)

SFON:

129815295(tgfa) 129844261

CCLU:

121575878 121578655(tgfa)

ELS:

105016898

OEP:	134026306(tgfa)

SFM:	108920173(tgfa)

PKI:	111848546(tgfa)

AROT:

135233798(tgfa)

CCOG:

133141204(tgfa)

LOC:	102693060(tgfa) 107077295

PSPA:

121303033(tgfa)

ARUT:

117397813 117966142

PSEX:

120538847(tgfa)

LCM:	102367184(TGFA)

CMK:	103190258(tgfa)

CPLA:

122542966

CPUN:

140459613

HOC:	132836929(tgfa)

SCAU:

119956165 119957477(tgfa)

LERI:

129713340

HAKA:

140740448(tgfa)

BFO:	118412018 118416734

» show all

Reference

PMID:6088071

Authors

Derynck R, Roberts AB, Winkler ME, Chen EY, Goeddel DV

Title

Human transforming growth factor-alpha: precursor structure and expression in E. coli.

Journal

Cell 38:287-97 (1984)
DOI:10.1016/0092-8674(84)90550-6

Sequence

[hsa:7039]

All links

Ontology (1)   
   GO (1)   
Gene (92)   
   MGENES (34)   
   RefGene (56)   
   OC (2)   
All databases (93)   

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