KEGG   ORTHOLOGY: K04361Help
Entry
K04361                      KO                                     

Name
EGFR, ERBB1
Definition
epidermal growth factor receptor [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04013  MAPK signaling pathway - fly
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04072  Phospholipase D signaling pathway
ko04144  Endocytosis
ko04151  PI3K-Akt signaling pathway
ko04214  Apoptosis - fly
ko04320  Dorso-ventral axis formation
ko04510  Focal adhesion
ko04520  Adherens junction
ko04540  Gap junction
ko04630  JAK-STAT signaling pathway
ko04810  Regulation of actin cytoskeleton
ko04912  GnRH signaling pathway
ko04915  Estrogen signaling pathway
ko04921  Oxytocin signaling pathway
ko04926  Relaxin signaling pathway
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing syndrome
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05131  Shigellosis
ko05160  Hepatitis C
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05219  Bladder cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Disease
H00014  Non-small cell lung cancer
H00016  Oral cancer
H00017  Esophageal cancer
H00022  Bladder cancer
H00028  Choriocarcinoma
H00030  Cervical cancer
H00031  Breast cancer
H00042  Glioma
H00055  Laryngeal cancer
H01508  Salivary gland cancer
H01559  Oropharyngeal cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04015 Rap1 signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04010 MAPK signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04013 MAPK signaling pathway - fly
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04012 ErbB signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04630 Jak-STAT signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04066 HIF-1 signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04068 FoxO signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04020 Calcium signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04072 Phospholipase D signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04151 PI3K-Akt signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09143 Cell growth and death
   04214 Apoptosis - fly
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04520 Adherens junction
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04540 Gap junction
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 09150 Organismal Systems
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04915 Estrogen signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04921 Oxytocin signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04926 Relaxin signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04928 Parathyroid hormone synthesis, secretion and action
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09158 Development and regeneration
   04320 Dorso-ventral axis formation
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05206 MicroRNAs in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05205 Proteoglycans in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05230 Central carbon metabolism in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05231 Choline metabolism in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05212 Pancreatic cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05225 Hepatocellular carcinoma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05226 Gastric cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05214 Glioma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05218 Melanoma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05219 Bladder cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05215 Prostate cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05213 Endometrial cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05224 Breast cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05223 Non-small cell lung cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05131 Shigellosis
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09172 Infectious disease: viral
   05160 Hepatitis C
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05163 Human cytomegalovirus infection
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05165 Human papillomavirus infection
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   01522 Endocrine resistance
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04361  EGFR, ERBB1; epidermal growth factor receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04361  EGFR, ERBB1; epidermal growth factor receptor
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   K04361  EGFR, ERBB1; epidermal growth factor receptor
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
  Exosomal proteins of pancreatic cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
  Exosomal proteins of bladder cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
BRITE hierarchy
Other DBs
GO: 0005006
Genes
HSA: 1956(EGFR)
PTR: 463415(EGFR)
PPS: 100974885(EGFR)
GGO: 101126190(EGFR)
PON: 100459280(EGFR)
NLE: 100597255(EGFR)
MCC: 613027(EGFR)
MCF: 102138724(EGFR)
CSAB: 103226055(EGFR)
RRO: 104675886(EGFR)
RBB: 108522039(EGFR)
CJC: 100412158(EGFR)
SBQ: 101047461(EGFR)
MMU: 13649(Egfr)
MCAL: 110304228(Egfr)
MPAH: 110330480(Egfr)
RNO: 24329(Egfr)
CGE: 100774580(Egfr)
NGI: 103748852
HGL: 101723771(Egfr)
CCAN: 109693753(Egfr)
OCU: 100008806(EGFR)
TUP: 102485304(EGFR)
CFA: 404306(EGFR)
VVP: 112925820(EGFR)
UMR: 103674660(EGFR)
UAH: 113257444(EGFR)
ORO: 101386858(EGFR)
ELK: 111157042
FCA: 100510799(EGFR)
PTG: 102967370(EGFR)
PPAD: 109267979(EGFR)
AJU: 106976977(EGFR)
BTA: 407217(EGFR)
BOM: 102269868
BIU: 109576048(EGFR)
BBUB: 102398103(EGFR)
CHX: 102172767(EGFR)
OAS: 780479(EGFR)
SSC: 397070(EGFR)
CFR: 102504272(EGFR)
CDK: 105105749(EGFR)
BACU: 103017029(EGFR)
LVE: 103071962(EGFR)
OOR: 101275398(EGFR)
DLE: 111184548(EGFR)
PCAD: 102975467(EGFR)
ECB: 100067755(EGFR)
EPZ: 103560128(EGFR)
EAI: 106824133(EGFR)
MYB: 102257758(EGFR)
MYD: 102775204(EGFR)
MNA: 107525996(EGFR)
HAI: 109388365(EGFR)
DRO: 112306897 112306912(EGFR)
PALE: 102893495(EGFR)
RAY: 107498193(EGFR)
LAV: 100659125(EGFR)
TMU: 101356822
MDO: 100029625(EGFR)
SHR: 100914017(EGFR)
PCW: 110204990(EGFR)
OAA: 100075894(EGFR)
GGA: 396494(EGFR)
MGP: 100543252(EGFR)
CJO: 107309802(EGFR)
NMEL: 110393050(EGFR)
APLA: 101797830(EGFR)
ACYG: 106046417(EGFR)
TGU: 100221035(EGFR)
LSR: 110471171(EGFR)
SCAN: 103819418(EGFR)
GFR: 102045482(EGFR)
FAB: 101818290(EGFR)
PHI: 102101445(EGFR)
PMAJ: 107200328(EGFR)
CCAE: 111923657(EGFR)
CCW: 104689262(EGFR)
ETL: 114057239(EGFR)
FPG: 101910521(EGFR)
FCH: 102058683(EGFR)
CLV: 102097879(EGFR)
EGZ: 104131586(EGFR)
NNI: 104012443(EGFR)
ACUN: 113477535(EGFR)
PADL: 103914859(EGFR)
AAM: 106495273(EGFR)
ASN: 102378285(EGFR)
AMJ: 102565209(EGFR)
PSS: 102443405(EGFR)
CMY: 102933326(EGFR)
CPIC: 101952725(EGFR)
ACS: 100562231(egfr)
PVT: 110081594(EGFR)
PBI: 103050691(EGFR)
PMUR: 107284695(EGFR)
TSR: 106539158(EGFR) 106554178
PMUA: 114607096(EGFR)
GJA: 107119225(EGFR)
XLA: 108719997(egfr.S) 724072(egfr.L)
XTR: 100492965(egfr)
DRE: 378478(egfra) 571431
IPU: 108280575(egfr)
PHYP: 113546391(egfr)
EEE: 113587946 113590490(egfr)
TRU: 101069322(egfr) 101073748
OLA: 101159776(egfr) 101169984
XCO: 114136421 114146596(egfr)
PRET: 103456976 103479868(egfr)
CVG: 107081719(egfr) 107098892
NFU: 107383161 107383833(egfr)
KMR: 108241698(egfr) 108250946
ALIM: 106531647 106533007(egfr)
CSEM: 103377298 103396351(egfr)
LCF: 108883329(egfr) 108894667
SDU: 111231258(egfr) 111237405
SLAL: 111647380 111652941(egfr)
HCQ: 109521299(egfr) 109530291
SFM: 108937670(egfr)
CMK: 103181270(egfr)
RTP: 109927384
SPU: 586488
SKO: 100372961
DME: Dmel_CG10079(Egfr)
DER: 6548211
DSI: Dsimw501_GD11601(Dsim_GD11601)
DSR: 110189726
DPE: 6592980
DMN: 108159444
DWI: 6637989
DAZ: 108615522
DNV: 108653770
DHE: 111592533
MDE: 101887261
LCQ: 111687210
AGA: AgaP_AGAP008819(EGFR)
AAG: 5564544
AME: 100577393
BIM: 100740344
BTER: 100645521
CCAL: 108632582
OBB: 114874001
MPHA: 105828088
AEC: 105144059
ACEP: 105627284
PBAR: 105427056
VEM: 105567241
HST: 105191569
DQU: 106742590
CFO: 105257833
LHU: 105676042
PGC: 109852274
OBO: 105287957
PCF: 106793740
NVI: 100118970(Egfr)
CSOL: 105367460
MDL: 103576901
TCA: 660037(DER)
DPA: 109536124
ATD: 109595878
NVL: 108556379
BMOR: 101741679
BMAN: 114245679
PMAC: 106717252
PRAP: 110998172
HAW: 110375773
TNL: 113507132
PXY: 105385471
API: 100168353
DNX: 107162454
AGS: 114127776
RMD: 113550916
BTAB: 109031082
CLEC: 106668239
ZNE: 110832144
FCD: 110842323
TUT: 107359081
DPTE: 113792070
CEL: CELE_ZK1067.1(let-23)
CBR: CBG00911(Cbr-let-23)
BMY: Bm1_48745
CRG: 105330118(Egfr) 105339116
LAK: 106153603
DGT: 114526923
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Shao H, Cheng HY, Cook RG, Tweardy DJ
  Title
Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor.
  Journal
Cancer Res 63:3923-30 (2003)
  Sequence
[hsa:1956]
Reference
  Authors
Habib AA, Chatterjee S, Park SK, Ratan RR, Lefebvre S, Vartanian T
  Title
The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome.
  Journal
J Biol Chem 276:8865-74 (2001)
DOI:10.1074/jbc.M008458200
  Sequence
[hsa:1956]
Reference
PMID:6328312
  Authors
Ullrich A, Coussens L, Hayflick JS, Dull TJ, Gray A, Tam AW, Lee J, Yarden Y, Libermann TA, Schlessinger J, et al.
  Title
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells.
  Journal
Nature 309:418-25 (1984)
  Sequence
[hsa:1956]

KEGG   ORTHOLOGY: K04362Help
Entry
K04362                      KO                                     

Name
FGFR1, CD331
Definition
fibroblast growth factor receptor 1 [EC:2.7.10.1]
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04520  Adherens junction
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04714  Thermogenesis
ko04810  Regulation of actin cytoskeleton
ko04928  Parathyroid hormone synthesis, secretion and action
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05215  Prostate cancer
ko05218  Melanoma
ko05224  Breast cancer
ko05230  Central carbon metabolism in cancer
Disease
H00031  Breast cancer
H00255  Hypogonadotropic hypogonadism
H00443  Osteoglophonic dysplasia
H00458  Syndromic craniosynostoses
H01207  Trigonocephaly
H01756  Pfeiffer syndrome
H01850  Hartsfield syndrome
H01988  Jackson-Weiss syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   04015 Rap1 signaling pathway
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   04010 MAPK signaling pathway
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   04151 PI3K-Akt signaling pathway
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   04550 Signaling pathways regulating pluripotency of stem cells
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
 09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
  09159 Environmental adaptation
   04714 Thermogenesis
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   05205 Proteoglycans in cancer
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   05230 Central carbon metabolism in cancer
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
  09162 Cancer: specific types
   05218 Melanoma
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   05215 Prostate cancer
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   05224 Breast cancer
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   00536 Glycosaminoglycan binding proteins
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04362  FGFR1, CD331; fibroblast growth factor receptor 1
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  FGFR family [OT]
   K04362  FGFR1, CD331; fibroblast growth factor receptor 1
CD molecules [BR:ko04090]
 Proteins
  K04362  CD331, FGFR1; fibroblast growth factor receptor 1
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Haparin
  Growth factors/receptors
   K04362  FGFR1, CD331; fibroblast growth factor receptor 1
BRITE hierarchy
Other DBs
GO: 0005007
Genes
HSA: 2260(FGFR1)
PTR: 464122(FGFR1)
PPS: 100988115(FGFR1)
GGO: 101152179(FGFR1)
PON: 100174545(FGFR1)
NLE: 100602423(FGFR1)
MCC: 700126(FGFR1)
MCF: 102144714(FGFR1)
CSAB: 103215648(FGFR1)
RRO: 104679640(FGFR1)
RBB: 108512401(FGFR1)
CJC: 100390192(FGFR1)
SBQ: 101033213(FGFR1)
MMU: 14182(Fgfr1)
MCAL: 110299550(Fgfr1)
MPAH: 110336809(Fgfr1)
RNO: 79114(Fgfr1)
MUN: 110563307(Fgfr1)
CGE: 100773586(Fgfr1)
NGI: 103745770(Fgfr1)
HGL: 101700324(Fgfr1)
CCAN: 109688936(Fgfr1)
OCU: 100351861(FGFR1)
TUP: 102484087(FGFR1)
CFA: 100856477(FGFR1)
VVP: 112916136(FGFR1)
AML: 100472630(FGFR1)
UMR: 103659146(FGFR1)
UAH: 113262086(FGFR1)
ORO: 101364849(FGFR1)
ELK: 111144420
FCA: 101086055(FGFR1)
PTG: 102972346(FGFR1)
PPAD: 109262303(FGFR1)
AJU: 106978376(FGFR1)
BTA: 281768(FGFR1)
BOM: 102267776(FGFR1)
BIU: 109553304(FGFR1)
BBUB: 102407288(FGFR1)
CHX: 102180282(FGFR1)
OAS: 780507(FGFR1)
SSC: 100153248(FGFR1)
CFR: 102515264(FGFR1)
CDK: 105105270(FGFR1)
BACU: 103017733(FGFR1)
LVE: 103069902(FGFR1)
OOR: 101279623(FGFR1)
DLE: 111173523(FGFR1)
PCAD: 102989551(FGFR1)
ECB: 100057614(FGFR1)
EPZ: 103560266(FGFR1)
EAI: 106824659(FGFR1)
MYB: 102253832(FGFR1)
MYD: 102759202(FGFR1)
MNA: 107535065(FGFR1)
HAI: 109373149(FGFR1)
DRO: 112306733(FGFR1)
PALE: 102898943(FGFR1)
RAY: 107515961(FGFR1)
MJV: 108403050(FGFR1)
LAV: 100662289(FGFR1)
TMU: 101342270
MDO: 100029852(FGFR1)
SHR: 100914347(FGFR1)
PCW: 110207578(FGFR1)
OAA: 100074240(FGFR1)
GGA: 396516(FGFR1)
MGP: 100547498(FGFR1)
CJO: 107323773(FGFR1)
NMEL: 110387131(FGFR1)
ACYG: 106044374(FGFR1)
TGU: 100221243(FGFR1)
LSR: 110473397(FGFR1)
SCAN: 103822693(FGFR1)
GFR: 102033908(FGFR1) 102037850
FAB: 101822220(FGFR1)
PHI: 102103637(FGFR1)
PMAJ: 107213845(FGFR1)
CCAE: 111922087 111938850(FGFR1)
CCW: 104694904(FGFR1)
ETL: 114066493(FGFR1)
FPG: 101914093(FGFR1)
FCH: 102055369(FGFR1)
CLV: 102085235(FGFR1)
EGZ: 104135322(FGFR1)
NNI: 104016019(FGFR1)
PADL: 103912362(FGFR1)
AAM: 106492992(FGFR1)
ASN: 102386174(FGFR1)
AMJ: 102574117(FGFR1)
PSS: 102461506(FGFR1)
CPIC: 101941076(FGFR1)
ACS: 100559018(fgfr1)
PVT: 110072166(FGFR1)
PBI: 103066603(FGFR1)
PMUR: 107289991(FGFR1)
TSR: 106545617(FGFR1) 106553189
PMUA: 114585343(FGFR1)
GJA: 107113006(FGFR1)
XLA: 394418(fgfr1.L) 397782(xfgfra2) 399444(fgfr1.S)
XTR: 548648(fgfr1)
NPR: 108791453(FGFR1)
DRE: 30705(fgfr1a)
AMEX: 103036914
TRU: 101073964 101078564(fgfr1)
LCO: 104936599(fgfr1) 104938329
OLA: 100125448(fgfr1) 101155126
CVG: 107081801
KMR: 108231094 108247308(fgfr1)
LCM: 102361014(FGFR1)
RTP: 109926304
CIN: 445706(fgfr)
SPU: 373310(FGFR)
NVI: 100114847
TSP: Tsp_00617
MYI: 110455439
OBI: 106883548
EGL: EGR_04208
AQU: 100632318
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1697263
  Authors
Dionne CA, Crumley G, Bellot F, Kaplow JM, Searfoss G, Ruta M, Burgess WH, Jaye M, Schlessinger J
  Title
Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.
  Journal
EMBO J 9:2685-92 (1990)
  Sequence
[hsa:2260]

KEGG   ORTHOLOGY: K05093Help
Entry
K05093                      KO                                     

Name
FGFR2, CD332
Definition
fibroblast growth factor receptor 2 [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04144  Endocytosis
ko04151  PI3K-Akt signaling pathway
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04810  Regulation of actin cytoskeleton
ko05200  Pathways in cancer
ko05215  Prostate cancer
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
Disease
H00018  Gastric cancer
H00458  Syndromic craniosynostoses
H00642  Lacrimo-auriculo-dento-digital syndrome
H01753  Antley-Bixler syndrome
H01754  Crouzon syndrome
H01755  Apert syndrome
H01756  Pfeiffer syndrome
H01988  Jackson-Weiss syndrome
H01989  Beare-Stevenson syndrome
H01991  Saethre-Chotzen syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
   04015 Rap1 signaling pathway
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
   04010 MAPK signaling pathway
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
   04151 PI3K-Akt signaling pathway
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
   05230 Central carbon metabolism in cancer
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
  09162 Cancer: specific types
   05226 Gastric cancer
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
   05215 Prostate cancer
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
   00536 Glycosaminoglycan binding proteins
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05093  FGFR2, CD332; fibroblast growth factor receptor 2
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  FGFR family [OT]
   K05093  FGFR2, CD332; fibroblast growth factor receptor 2
CD molecules [BR:ko04090]
 Proteins
  K05093  CD332, FGFR2; fibroblast growth factor receptor 2
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Haparin
  Growth factors/receptors
   K05093  FGFR2, CD332; fibroblast growth factor receptor 2
BRITE hierarchy
Other DBs
GO: 0005007
Genes
HSA: 2263(FGFR2)
PTR: 466220(FGFR2)
PPS: 100981139(FGFR2)
GGO: 101153046(FGFR2)
PON: 100171540(FGFR2)
NLE: 100598157(FGFR2)
MCC: 715949(FGFR2)
MCF: 102143086(FGFR2)
CSAB: 103216628(FGFR2)
RRO: 104675847(FGFR2)
RBB: 108529768(FGFR2)
CJC: 100393573(FGFR2)
SBQ: 101033845(FGFR2)
MMU: 14183(Fgfr2)
MCAL: 110299396(Fgfr2)
MPAH: 110326449(Fgfr2)
RNO: 25022(Fgfr2)
MUN: 110554946(Fgfr2)
CGE: 100763455(Fgfr2)
NGI: 103729272(Fgfr2)
HGL: 101709077(Fgfr2)
CCAN: 109691649(Fgfr2)
OCU: 100009417(FGFR2)
TUP: 102484403(FGFR2)
CFA: 415125(FGFR2)
VVP: 112916723(FGFR2)
AML: 100468267(FGFR2)
UMR: 103657802(FGFR2)
UAH: 113252011(FGFR2)
ORO: 101381278(FGFR2)
FCA: 101095198(FGFR2)
PTG: 102964142(FGFR2)
PPAD: 109272992(FGFR2)
AJU: 106969379(FGFR2)
BTA: 404193(FGFR2)
BOM: 102270743(FGFR2)
BIU: 109553142(FGFR2)
BBUB: 102402932(FGFR2)
CHX: 102170938(FGFR2)
OAS: 443548(FGFR2)
SSC: 396762(FGFR2)
CFR: 102516073(FGFR2)
CDK: 105104060(FGFR2)
BACU: 103012184(FGFR2)
LVE: 103090812(FGFR2)
OOR: 101272068(FGFR2)
DLE: 111172240(FGFR2)
PCAD: 102982044(FGFR2)
ECB: 100033956(FGFR2)
EPZ: 103547114(FGFR2)
EAI: 106846935(FGFR2)
MYB: 102254053(FGFR2)
MYD: 102763283(FGFR2)
MNA: 107532684(FGFR2)
HAI: 109383003(FGFR2)
DRO: 112300272(FGFR2)
PALE: 102882899(FGFR2)
RAY: 107512997(FGFR2)
MJV: 108395520(FGFR2)
TMU: 101357035
MDO: 100025727(FGFR2)
SHR: 100932215(FGFR2)
PCW: 110209582(FGFR2)
OAA: 100084641(FGFR2)
GGA: 396259(FGFR2)
MGP: 100540905
CJO: 107316195(FGFR2)
NMEL: 110399304(FGFR2)
APLA: 101791540(FGFR2)
ACYG: 106038987(FGFR2)
TGU: 100223379(FGFR2)
LSR: 110469999(FGFR2)
SCAN: 103813785(FGFR2)
GFR: 102038840(FGFR2)
FAB: 101812169(FGFR2)
PHI: 102105117(FGFR2)
PMAJ: 107206911(FGFR2)
CCAE: 111931374(FGFR2)
CCW: 104694675(FGFR2)
ETL: 114065192(FGFR2)
FPG: 101913692(FGFR2)
FCH: 102056102(FGFR2)
CLV: 102091137(FGFR2)
EGZ: 104123669(FGFR2)
NNI: 104020574(FGFR2)
ACUN: 113481500(FGFR2)
PADL: 103918542(FGFR2)
AAM: 106499024(FGFR2)
ASN: 102382394(FGFR2)
AMJ: 102564591(FGFR2)
PSS: 102443772(FGFR2)
CMY: 102938554(FGFR2)
CPIC: 101933273(FGFR2)
ACS: 100562611(fgfr2)
PVT: 110075320(FGFR2)
PBI: 103057830(FGFR2)
PMUR: 107288600(FGFR2)
PMUA: 114597424(FGFR2)
GJA: 107112647(FGFR2)
XLA: 108697372(fgfr2.S) 399325(fgfr2.L)
XTR: 100124910(fgfr2)
NPR: 108793050(FGFR2)
DRE: 352940(fgfr2)
SANH: 107655670 107679170(fgfr2)
SGH: 107585454 107597642(fgfr2)
IPU: 108263349(fgfr2)
PHYP: 113542009(fgfr2)
AMEX: 103024961
EEE: 113588015(fgfr2)
TRU: 101073665(fgfr2)
LCO: 104925607(fgfr2)
NCC: 104962476
MZE: 101463957(fgfr2)
ONL: 100699731(fgfr2)
OLA: 100049483(fgfr2) 101174210
XMA: 102233809
XCO: 114138295
CVG: 107081753(fgfr2)
NFU: 107375397(fgfr2)
KMR: 108240654(fgfr2)
ALIM: 106526530(fgfr2)
AOCE: 111571792(fgfr2)
LCF: 108885762(fgfr2)
SDU: 111220545(fgfr2)
SLAL: 111658940(fgfr2)
HCQ: 109523130(fgfr2)
BPEC: 110168143(fgfr2)
MALB: 109959332(fgfr2)
OTW: 112223890 112252740(fgfr2)
ELS: 105010630(fgfr2)
SFM: 108925828(fgfr2)
PKI: 111839944(fgfr2)
LCM: 102349925(FGFR2)
CMK: 103185425(fgfr2)
RTP: 109910693(fgfr2)
DME: Dmel_CG32134(btl)
DER: 6545596
DSI: Dsimw501_GD14480(Dsim_GD14480)
DSR: 110190281
DPE: 113565986
DMN: 108152297
DWI: 6639356
DAZ: 108612213
DNV: 108651226
DHE: 111600927
MDE: 101901067
LCQ: 111675215
AME: 413200
BIM: 100747636
BTER: 100643345
OBB: 114878227
SOC: 105196299
MPHA: 105830905
AEC: 105147047
ACEP: 105624923
VEM: 105565532
DQU: 106748031
CFO: 105249959
LHU: 105679827
OBO: 105278054
PCF: 106786979
MDL: 103569982
TCA: 659434(DFR1)
NVL: 108565311
PMAC: 106715481
RMD: 113554812
BTAB: 109038511
CLEC: 106664605
DPTE: 113797385
PTEP: 107438841
CRG: 105321229
OBI: 106868677
SHX: MS3_01300
AQU: 100633582
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1697263
  Authors
Dionne CA, Crumley G, Bellot F, Kaplow JM, Searfoss G, Ruta M, Burgess WH, Jaye M, Schlessinger J
  Title
Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.
  Journal
EMBO J 9:2685-92 (1990)
  Sequence
[hsa:2263]

KEGG   ORTHOLOGY: K05094Help
Entry
K05094                      KO                                     

Name
FGFR3, CD333
Definition
fibroblast growth factor receptor 3 [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04144  Endocytosis
ko04151  PI3K-Akt signaling pathway
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04810  Regulation of actin cytoskeleton
ko05200  Pathways in cancer
ko05206  MicroRNAs in cancer
ko05219  Bladder cancer
ko05230  Central carbon metabolism in cancer
Disease
H00010  Multiple myeloma
H00022  Bladder cancer
H00458  Syndromic craniosynostoses
H00505  FGFR3-related short limb skeletal dysplasia
H00642  Lacrimo-auriculo-dento-digital syndrome
H00997  CATSHL syndrome
H01749  Achondroplasia
H01750  Thanatophoric dysplasia
H01754  Crouzon syndrome
H01990  Muenke syndrome
H02068  Hypochondroplasia
H02069  SADDAN
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
   04015 Rap1 signaling pathway
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
   04010 MAPK signaling pathway
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
   04151 PI3K-Akt signaling pathway
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
   05206 MicroRNAs in cancer
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
   05230 Central carbon metabolism in cancer
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
  09162 Cancer: specific types
   05219 Bladder cancer
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05094  FGFR3, CD333; fibroblast growth factor receptor 3
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  FGFR family [OT]
   K05094  FGFR3, CD333; fibroblast growth factor receptor 3
CD molecules [BR:ko04090]
 Proteins
  K05094  CD333, FGFR3; fibroblast growth factor receptor 3
BRITE hierarchy
Other DBs
GO: 0005007
Genes
HSA: 2261(FGFR3)
PTR: 461067(FGFR3)
PPS: 100976551(FGFR3)
GGO: 101139997(FGFR3)
PON: 100433126(FGFR3)
NLE: 100591839(FGFR3)
MCC: 712829(FGFR3)
MCF: 102128947(FGFR3)
CSAB: 103246479(FGFR3)
RRO: 104678934(FGFR3)
RBB: 108532286(FGFR3)
CJC: 100409938(FGFR3)
SBQ: 101051421(FGFR3)
MMU: 14184(Fgfr3)
MCAL: 110293909(Fgfr3)
MPAH: 110330788(Fgfr3)
RNO: 84489(Fgfr3)
MUN: 110557305(Fgfr3)
CGE: 100764560(Fgfr3)
NGI: 103741127(Fgfr3)
HGL: 101711651(Fgfr3)
CCAN: 109695016(Fgfr3)
TUP: 102500041(FGFR3)
CFA: 488808(FGFR3)
VVP: 112922612(FGFR3)
AML: 100481826(FGFR3)
UMR: 103676958(FGFR3)
UAH: 113245744(FGFR3)
ORO: 101381434(FGFR3)
ELK: 111149137
FCA: 100141386(FGFR3)
PPAD: 109269781(FGFR3)
AJU: 106978850(FGFR3)
BTA: 281769(FGFR3)
BOM: 102264670(FGFR3)
BIU: 109560724(FGFR3)
BBUB: 102395462(FGFR3)
CHX: 102187310(FGFR3)
OAS: 554324(FGFR3)
SSC: 100514115(FGFR3)
CFR: 102508259 102512878(FGFR3)
CDK: 105100875(FGFR3)
BACU: 103002473(FGFR3)
LVE: 103086424(FGFR3)
OOR: 101273169(FGFR3)
DLE: 111164861(FGFR3)
PCAD: 102982240(FGFR3)
ECB: 100034114(FGFR3)
EPZ: 103556997(FGFR3)
EAI: 106830606(FGFR3)
MNA: 107524118(FGFR3)
HAI: 109390958(FGFR3)
DRO: 112316660(FGFR3)
PALE: 102878342(FGFR3)
RAY: 107518024(FGFR3)
MJV: 108383914(FGFR3)
LAV: 100674054(FGFR3)
TMU: 101341002
MDO: 100023287(FGFR3)
SHR: 100913979(FGFR3)
PCW: 110212245(FGFR3)
OAA: 100084071(FGFR3)
GGA: 396515(FGFR3)
MGP: 100543461(FGFR3)
CJO: 107313983(FGFR3)
NMEL: 110398027(FGFR3)
APLA: 101804995(FGFR3)
ACYG: 106034332(FGFR3)
TGU: 100218924(FGFR3)
LSR: 110473290(FGFR3)
SCAN: 103826117(FGFR3)
GFR: 102044988(FGFR3)
FAB: 101812160(FGFR3)
PHI: 102114034(FGFR3)
PMAJ: 107203422(FGFR3)
CCAE: 111927721(FGFR3)
CCW: 104690922(FGFR3)
ETL: 114061475(FGFR3)
FPG: 101920747(FGFR3)
FCH: 102052231(FGFR3)
CLV: 102098275(FGFR3)
EGZ: 104130196(FGFR3)
NNI: 104018093(FGFR3)
ACUN: 113479202(FGFR3)
PADL: 103920985(FGFR3)
AAM: 106498761(FGFR3)
ASN: 102371740(FGFR3)
AMJ: 106736800(FGFR3)
PSS: 102444715(FGFR3)
CMY: 102939991(FGFR3)
CPIC: 101933794(FGFR3)
PVT: 110085587(FGFR3)
PBI: 103067086(FGFR3)
TSR: 106555648
PMUA: 114596954(FGFR3)
GJA: 107122537
XLA: 399347(fgfr3.S) 779370(fgfr3.L)
XTR: 100196923(fgfr3)
NPR: 108788840(FGFR3)
DRE: 58129(fgfr3)
CCAR: 109098492
IPU: 108263592
PHYP: 113539741(fgfr3)
AMEX: 103045058(fgfr3)
EEE: 113589671(fgfr3)
TRU: 101063860(fgfr3)
LCO: 104926793(fgfr3)
MZE: 101476450(fgfr3)
ONL: 100689850(fgfr3)
OLA: 100049424(fgfr3)
XMA: 102228238
XCO: 114134047(fgfr3)
PRET: 103458160
NFU: 107391665
ALIM: 106519945(fgfr3)
AOCE: 111580110(fgfr3)
CSEM: 103383204(fgfr3)
LCF: 108889150(fgfr3)
SDU: 111226196(fgfr3)
SLAL: 111646819(fgfr3) 111648819
HCQ: 109520993(fgfr3)
BPEC: 110155643(fgfr3)
MALB: 109962419(fgfr3)
OTW: 112241682
ELS: 105015916(fgfr3)
SFM: 108920925(fgfr3)
PKI: 111844207(fgfr3)
LCM: 102364583(FGFR3)
CMK: 103181516(fgfr3)
DME: Dmel_CG7223(htl)
DER: 6552001
DSI: Dsimw501_GD20204(Dsim_GD20204)
DSR: 110189345
DHE: 111601342
PXY: 105390898
FCD: 110854753
TUT: 107368562
PTEP: 107437526
OBI: 106873489
HMG: 100206525(FGFR) 100214111
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Terada M, Shimizu A, Sato N, Miyakaze SI, Katayama H, Kurokawa-Seo M
  Title
Fibroblast growth factor receptor 3 lacking the Ig IIIb and transmembrane domains secreted from human squamous cell carcinoma DJM-1 binds to FGFs.
  Journal
Mol Cell Biol Res Commun 4:365-73 (2001)
DOI:10.1006/mcbr.2001.0306
  Sequence
[hsa:2261]

KEGG   ORTHOLOGY: K05095Help
Entry
K05095                      KO                                     

Name
FGFR4, CD334
Definition
fibroblast growth factor receptor 4 [EC:2.7.10.1]
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04144  Endocytosis
ko04151  PI3K-Akt signaling pathway
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04810  Regulation of actin cytoskeleton
ko05200  Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05095  FGFR4, CD334; fibroblast growth factor receptor 4
   04015 Rap1 signaling pathway
    K05095  FGFR4, CD334; fibroblast growth factor receptor 4
   04010 MAPK signaling pathway
    K05095  FGFR4, CD334; fibroblast growth factor receptor 4
   04151 PI3K-Akt signaling pathway
    K05095  FGFR4, CD334; fibroblast growth factor receptor 4
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K05095  FGFR4, CD334; fibroblast growth factor receptor 4
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K05095  FGFR4, CD334; fibroblast growth factor receptor 4
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05095  FGFR4, CD334; fibroblast growth factor receptor 4
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05095  FGFR4, CD334; fibroblast growth factor receptor 4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05095  FGFR4, CD334; fibroblast growth factor receptor 4
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05095  FGFR4, CD334; fibroblast growth factor receptor 4
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05095  FGFR4, CD334; fibroblast growth factor receptor 4
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  FGFR family [OT]
   K05095  FGFR4, CD334; fibroblast growth factor receptor 4
CD molecules [BR:ko04090]
 Proteins
  K05095  CD334, FGFR4; fibroblast growth factor receptor 4
BRITE hierarchy
Other DBs
GO: 0005007
Genes
HSA: 2264(FGFR4)
PTR: 462301(FGFR4)
PPS: 100991315(FGFR4)
GGO: 101145205(FGFR4)
PON: 100461105(FGFR4)
NLE: 100582351(FGFR4)
MCC: 698494(FGFR4)
MCF: 102118990(FGFR4)
CSAB: 103245042(FGFR4)
RRO: 104680447(FGFR4)
RBB: 108512216 108544759(FGFR4)
CJC: 100414348(FGFR4)
SBQ: 101027585(FGFR4)
MMU: 14186(Fgfr4)
MCAL: 110307648(Fgfr4)
MPAH: 110333996(Fgfr4)
RNO: 25114(Fgfr4)
MUN: 110549775(Fgfr4)
CGE: 100765320(Fgfr4)
NGI: 103732354(Fgfr4)
HGL: 101700214(Fgfr4)
CCAN: 109685768(Fgfr4)
OCU: 100355275(FGFR4)
TUP: 102475159(FGFR4)
CFA: 489095(FGFR4)
VVP: 112925658(FGFR4)
AML: 100477678(FGFR4)
UMR: 103664454(FGFR4)
UAH: 113264137(FGFR4)
ORO: 101381264(FGFR4)
ELK: 111140867
FCA: 101100864(FGFR4)
PTG: 102965504(FGFR4)
PPAD: 109267570(FGFR4)
AJU: 106975403(FGFR4)
BTA: 317696(FGFR4)
BOM: 102267813(FGFR4)
BIU: 109561893(FGFR4)
BBUB: 102413025(FGFR4)
CHX: 102183685(FGFR4)
OAS: 101120660(FGFR4)
SSC: 100127133(FGFR4)
CFR: 102510147(FGFR4)
CDK: 105099582(FGFR4)
BACU: 103013305(FGFR4)
LVE: 103078406(FGFR4)
OOR: 101280121(FGFR4)
DLE: 111169850(FGFR4)
PCAD: 102984527 114483863(FGFR4)
ECB: 100068679(FGFR4)
EPZ: 103557327(FGFR4)
EAI: 106827191(FGFR4)
MYB: 102258015(FGFR4)
MYD: 102759469(FGFR4)
MNA: 107529769(FGFR4)
HAI: 109389796(FGFR4)
DRO: 112320339(FGFR4)
PALE: 102879288(FGFR4)
RAY: 107517559(FGFR4)
MJV: 108398432(FGFR4)
LAV: 100672193(FGFR4)
TMU: 101344195
MDO: 100031838(FGFR4)
SHR: 100919819(FGFR4)
PCW: 110216795(FGFR4)
OAA: 100081967(FGFR4)
GGA: 395603(FGFR4)
MGP: 100544316(FGFR4)
CJO: 107320486(FGFR4)
NMEL: 110405535(FGFR4)
APLA: 110354206(FGFR4)
ACYG: 106049509(FGFR4)
TGU: 100226243(FGFR4)
LSR: 110470830(FGFR4)
SCAN: 103817508(FGFR4)
GFR: 102044508(FGFR4)
FAB: 101814756(FGFR4)
PHI: 102109120(FGFR4)
PMAJ: 107210899(FGFR4)
CCAE: 111943286(FGFR4)
CCW: 104689519(FGFR4)
ETL: 114063827(FGFR4)
FPG: 101917722(FGFR4)
FCH: 102055424(FGFR4)
CLV: 102085088(FGFR4)
EGZ: 104128866(FGFR4)
NNI: 104018994(FGFR4)
ACUN: 113485394(FGFR4)
PADL: 103918814(FGFR4)
AAM: 106491594(FGFR4)
ASN: 102368985(FGFR4)
AMJ: 102567148(FGFR4)
CMY: 102930286(FGFR4)
CPIC: 101931613(FGFR4)
ACS: 100554153(fgfr4)
PVT: 110077562(FGFR4)
PBI: 103052689(FGFR4)
PMUR: 107295676(FGFR4)
TSR: 106540885
PMUA: 114591436(FGFR4)
GJA: 107111538(FGFR4)
XLA: 397701(fgfr4.L) 398181(fgfr4.S)
XTR: 549077(fgfr4)
NPR: 108783764(FGFR4)
DRE: 100000160(fgfr4)
IPU: 108279190(fgfr4)
PHYP: 113541573(fgfr4)
AMEX: 103029904(fgfr4)
EEE: 113571264(fgfr4)
TRU: 101068538
LCO: 104918948(fgfr4)
NCC: 104941715
MZE: 101477307
ONL: 100692465
OLA: 100049521
XMA: 102216451
XCO: 114153109
PRET: 103460000(fgfr4)
CVG: 107090685
NFU: 107386693(fgfr4)
KMR: 108238084
ALIM: 106533801
CSEM: 103394934
POV: 109628630(fgfr4)
LCF: 108893819
SDU: 111234275
SLAL: 111659966(fgfr4)
HCQ: 109518129
BPEC: 110156464
MALB: 109959288
ELS: 105011125(fgfr4)
SFM: 108920074(fgfr4)
PKI: 111847950 111860895(fgfr4)
LCM: 102345296(FGFR4)
RTP: 109914322
DGT: 114533984
AQU: 100633399
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1709094
  Authors
Partanen J, Makela TP, Eerola E, Korhonen J, Hirvonen H, Claesson-Welsh L, Alitalo K
  Title
FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern.
  Journal
EMBO J 10:1347-54 (1991)
  Sequence
[hsa:2264]

KEGG   ORTHOLOGY: K02583Help
Entry
K02583                      KO                                     

Name
NGFR, TNFRSF16, CD271
Definition
tumor necrosis factor receptor superfamily member 16
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04151  PI3K-Akt signaling pathway
ko04215  Apoptosis - multiple species
ko04722  Neurotrophin signaling pathway
ko05202  Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K02583  NGFR, TNFRSF16, CD271; tumor necrosis factor receptor superfamily member 16
   04015 Rap1 signaling pathway
    K02583  NGFR, TNFRSF16, CD271; tumor necrosis factor receptor superfamily member 16
   04010 MAPK signaling pathway
    K02583  NGFR, TNFRSF16, CD271; tumor necrosis factor receptor superfamily member 16
   04151 PI3K-Akt signaling pathway
    K02583  NGFR, TNFRSF16, CD271; tumor necrosis factor receptor superfamily member 16
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K02583  NGFR, TNFRSF16, CD271; tumor necrosis factor receptor superfamily member 16
 09140 Cellular Processes
  09143 Cell growth and death
   04215 Apoptosis - multiple species
    K02583  NGFR, TNFRSF16, CD271; tumor necrosis factor receptor superfamily member 16
 09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K02583  NGFR, TNFRSF16, CD271; tumor necrosis factor receptor superfamily member 16
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K02583  NGFR, TNFRSF16, CD271; tumor necrosis factor receptor superfamily member 16
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K02583  NGFR, TNFRSF16, CD271; tumor necrosis factor receptor superfamily member 16
   04090 CD molecules
    K02583  NGFR, TNFRSF16, CD271; tumor necrosis factor receptor superfamily member 16
Cytokine receptors [BR:ko04050]
 Tumor necrosis factor receptors
  TNF receptor superfamily
   K02583  NGFR, TNFRSF16, CD271; tumor necrosis factor receptor superfamily member 16
CD molecules [BR:ko04090]
 Proteins
  K02583  CD271, NGFR; nerve growth factor receptor (TNFR superfamily, member 16)
BRITE hierarchy
Other DBs
GO: 0005031 0043121 0048406
Genes
HSA: 4804(NGFR)
PTR: 455206(NGFR)
PPS: 100969001(NGFR)
GGO: 101139048(NGFR)
PON: 100456038(NGFR)
NLE: 100597065(NGFR)
MCC: 574304(NGFR)
MCF: 102115306(NGFR)
CSAB: 103243642(NGFR)
RRO: 104659825(NGFR)
RBB: 108516504(NGFR)
CJC: 100392306(NGFR)
SBQ: 101047376(NGFR)
MMU: 18053(Ngfr)
MCAL: 110305182(Ngfr)
MPAH: 110331904(Ngfr)
RNO: 24596(Ngfr)
MUN: 110551211(Ngfr)
CGE: 100755566(Ngfr)
NGI: 103738367(Ngfr)
HGL: 101724251(Ngfr)
CCAN: 109691411(Ngfr)
OCU: 100349095(NGFR)
TUP: 102498614(NGFR)
CFA: 491071(NGFR)
VVP: 112918130(NGFR)
AML: 100478241(NGFR)
UMR: 103661017(NGFR)
UAH: 113265602(NGFR)
ORO: 101365058(NGFR)
ELK: 111151744
FCA: 101101519(NGFR)
PTG: 102953999(NGFR)
PPAD: 109247323(NGFR)
AJU: 106985158(NGFR)
BTA: 353110(NGFR)
BOM: 102269800(NGFR)
BIU: 109574393(NGFR)
BBUB: 102413808(NGFR)
CHX: 102190168(NGFR)
OAS: 101119064(NGFR)
SSC: 100525607(NGFR)
CFR: 102511996(NGFR)
CDK: 105104837(NGFR)
BACU: 103015465(NGFR)
LVE: 103076750(NGFR)
OOR: 101283550(NGFR)
DLE: 111166426(NGFR)
PCAD: 102984762(NGFR)
ECB: 100069694(NGFR)
EPZ: 103551072(NGFR)
EAI: 106826528(NGFR)
MYB: 102244827(NGFR)
MYD: 102774816(NGFR)
MNA: 107539187(NGFR)
HAI: 109380655(NGFR)
DRO: 112316485(NGFR)
PALE: 102882941(NGFR)
RAY: 107517615(NGFR)
MJV: 108391063(NGFR)
LAV: 100671102(NGFR)
TMU: 101358935
MDO: 100021774(NGFR)
SHR: 100927086(NGFR) 100931911
PCW: 110215860(NGFR) 110216984
OAA: 100091625(NGFR)
GGA: 425805(NGFR)
MGP: 100545967(NGFR)
CJO: 107325256(NGFR)
NMEL: 110388550(NGFR) 110392104
APLA: 101803771(NGFR) 113841940
ACYG: 106048777(NGFR)
TGU: 115490717(NGFR)
LSR: 110468043 110474785(NGFR)
SCAN: 103821808(NGFR)
GFR: 102037350(NGFR)
FAB: 101810901(NGFR)
PHI: 102100883(NGFR)
PMAJ: 107198675(NGFR)
CCAE: 111945474
ETL: 114070123(NGFR)
FPG: 101911631(NGFR)
FCH: 102054509(NGFR)
CLV: 102085992(NGFR)
EGZ: 104129326(NGFR)
NNI: 104012242(NGFR)
ACUN: 113489238(NGFR)
PADL: 103915202(NGFR)
ASN: 102378300 102378692(NGFR)
AMJ: 102568202 102574002(NGFR)
PSS: 102455379(NGFR) 102462804
CMY: 102935599(NGFR) 102947773
CPIC: 101944126(NGFR) 101949178
ACS: 100552995(ngfr) 103282716
PVT: 110069991 110090041(NGFR)
PBI: 103056968 103063431(NGFR)
PMUR: 107282662(NGFR) 107286004
PMUA: 114581752(NGFR) 114607263
GJA: 107108719(NGFR) 107120099
XLA: 373821(p75ntrb-A) 398129(p75NTRa) 398134 432338(ngfr.S)
XTR: 100493992(ngfr) 493361(ngfr)
NPR: 108784008(NGFR) 108799902
DRE: 100535003(ngfra) 564338(ngfrb) 572204(nradd)
IPU: 108260737(ngfr) 108267207 108273578(NGFR)
NFU: 107378519(ngfr) 107387921
CMK: 103173289 103183821(ngfr)
RTP: 109914800 109926902(ngfr)
APLC: 110986889
SKO: 100313698
DPTE: 113795693
TSP: Tsp_05323
PCAN: 112561184
CRG: 105346085
MYI: 110442388
OBI: 106874456
LAK: 106152162
SHX: MS3_00310
HMG: 101240653
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3022937
  Authors
Johnson D, Lanahan A, Buck CR, Sehgal A, Morgan C, Mercer E, Bothwell M, Chao M
  Title
Expression and structure of the human NGF receptor.
  Journal
Cell 47:545-54 (1986)
DOI:10.1016/0092-8674(86)90619-7
  Sequence
[hsa:4804]
Reference
  Authors
Patapoutian A, Reichardt LF
  Title
Trk receptors: mediators of neurotrophin action.
  Journal
Curr Opin Neurobiol 11:272-80 (2001)
DOI:10.1016/S0959-4388(00)00208-7

KEGG   ORTHOLOGY: K03176Help
Entry
K03176                      KO                                     

Name
NTRK1, TRKA
Definition
neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04722  Neurotrophin signaling pathway
ko04750  Inflammatory mediator regulation of TRP channels
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05216  Thyroid cancer
ko05230  Central carbon metabolism in cancer
Disease
H00032  Thyroid cancer
H00043  Neuroblastoma
H00265  Hereditary sensory and autonomic neuropathy
H01836  Congenital pain insensitivity with anhidrosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   04010 MAPK signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   04151 PI3K-Akt signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
 09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   05202 Transcriptional misregulation in cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   05230 Central carbon metabolism in cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
  09162 Cancer: specific types
   05216 Thyroid cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  TRK family [OT]
   K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
BRITE hierarchy
Genes
HSA: 4914(NTRK1)
PTR: 457408(NTRK1)
PPS: 100995426(NTRK1)
GGO: 101125993(NTRK1)
PON: 100452269(NTRK1)
NLE: 100585466(NTRK1)
MCC: 719670(NTRK1)
MCF: 102129364(NTRK1)
CSAB: 103223823(NTRK1)
RRO: 104676442(NTRK1)
RBB: 108515538(NTRK1)
CJC: 103789024(NTRK1)
SBQ: 101035626(NTRK1)
MMU: 18211(Ntrk1)
MCAL: 110290875(Ntrk1)
MPAH: 110319787(Ntrk1)
RNO: 59109(Ntrk1)
MUN: 110564977(Ntrk1)
CGE: 100751271(Ntrk1)
NGI: 103750263(Ntrk1)
HGL: 101724441(Ntrk1)
CCAN: 109686202(Ntrk1)
OCU: 100354292(NTRK1)
TUP: 102485200(NTRK1)
CFA: 490404(NTRK1)
VVP: 112918800(NTRK1)
AML: 100474165(NTRK1)
UAH: 113245211(NTRK1)
ORO: 101374117(NTRK1)
ELK: 111138872
FCA: 101081603(NTRK1)
PPAD: 109256209(NTRK1)
AJU: 106988854(NTRK1)
BTA: 353111(NTRK1)
BOM: 102264869(NTRK1)
BIU: 109556725(NTRK1)
BBUB: 102402551(NTRK1)
CHX: 102172584(NTRK1)
OAS: 101109763(NTRK1)
SSC: 100154471(NTRK1)
CFR: 102518397(NTRK1)
CDK: 105105672(NTRK1)
BACU: 103003654(NTRK1)
LVE: 103071756(NTRK1)
OOR: 101273503(NTRK1)
DLE: 111167102(NTRK1)
PCAD: 102990275(NTRK1)
ECB: 100064594(NTRK1)
EPZ: 103548862(NTRK1) 103548863
EAI: 106828447(NTRK1)
MYD: 102765751(NTRK1)
MNA: 107543738(NTRK1)
HAI: 109393379(NTRK1)
DRO: 112315668(NTRK1)
PALE: 112472150(NTRK1)
RAY: 107521477(NTRK1)
MJV: 108383338(NTRK1)
LAV: 100668650(NTRK1)
TMU: 101351378
MDO: 100618744(NTRK1)
SHR: 100916388(NTRK1)
PCW: 110212119(NTRK1)
OAA: 103167743(NTRK1)
GGA: 396337(NTRK1)
MGP: 100541244(NTRK1)
CJO: 107324385(NTRK1)
NMEL: 110388022(NTRK1)
TGU: 115498457(NTRK1)
LSR: 110471556(NTRK1)
SCAN: 103824820(NTRK1)
GFR: 102039729(NTRK1)
FAB: 101810326(NTRK1)
PHI: 102113646(NTRK1)
PMAJ: 107214529(NTRK1)
CCW: 104683563(NTRK1)
ETL: 114071558(NTRK1)
FPG: 101920297(NTRK1)
FCH: 102060232(NTRK1)
CLV: 102086876(NTRK1)
NNI: 104015011(NTRK1)
AAM: 106495087(NTRK1)
ASN: 102381668(NTRK1)
AMJ: 102568424(NTRK1)
PSS: 102456174(NTRK1)
CMY: 102940175(NTRK1)
CPIC: 101934097(NTRK1)
ACS: 100556611(ntrk1)
PVT: 110081467(NTRK1)
PBI: 103064232(NTRK1)
PMUR: 107298512(NTRK1)
TSR: 106540381
PMUA: 114586656(NTRK1)
GJA: 107114884(NTRK1)
XTR: 100489637(ntrk1)
NPR: 108802180(NTRK1)
DRE: 30546(ntrk1)
SRX: 107726660(ntrk1) 107728446
IPU: 108256584(ntrk1)
PHYP: 113532627(ntrk1)
AMEX: 103025260(ntrk1)
EEE: 113571898(ntrk1)
TRU: 101074407(ntrk1)
LCO: 104933369(ntrk1)
NCC: 104949794(ntrk1)
MZE: 101473195(ntrk1)
ONL: 100699013(ntrk1)
OLA: 101164184(ntrk1)
XMA: 102217423
XCO: 114141649(ntrk1)
PRET: 103477579(ntrk1)
CVG: 107081138 107101837(ntrk1)
NFU: 107379148(ntrk1)
KMR: 108246005(ntrk1)
ALIM: 106528305(ntrk1)
AOCE: 111579099(ntrk1)
CSEM: 103388944(ntrk1)
POV: 109642014(ntrk1)
LCF: 108899467(ntrk1)
SDU: 111222591(ntrk1)
SLAL: 111655673(ntrk1)
HCQ: 109512189(ntrk1)
BPEC: 110172749
MALB: 109965566(ntrk1)
ELS: 105019278(ntrk1)
SFM: 108926773(ntrk1) 108930374
LCM: 102354132(NTRK1)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Tacconelli A, Farina AR, Cappabianca L, Desantis G, Tessitore A, Vetuschi A, Sferra R, Rucci N, Argenti B, Screpanti I, Gulino A, Mackay AR
  Title
TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma.
  Journal
Cancer Cell 6:347-60 (2004)
DOI:10.1016/j.ccr.2004.09.011
  Sequence
[hsa:4914]

KEGG   ORTHOLOGY: K04360Help
Entry
K04360                      KO                                     

Name
NTRK2, TRKB
Definition
neurotrophic tyrosine kinase receptor type 2 [EC:2.7.10.1]
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04722  Neurotrophin signaling pathway
ko05034  Alcoholism
Disease
H00043  Neuroblastoma
H00606  Early infantile epileptic encephalopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
   04010 MAPK signaling pathway
    K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
   04151 PI3K-Akt signaling pathway
    K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
 09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
 09160 Human Diseases
  09165 Substance dependence
   05034 Alcoholism
    K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  TRK family [OT]
   K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
BRITE hierarchy
Genes
HSA: 4915(NTRK2)
PTR: 735394(NTRK2)
PPS: 100994887(NTRK2)
GGO: 101140182(NTRK2)
PON: 100441207(NTRK2)
NLE: 100605330(NTRK2)
MCC: 709757(NTRK2)
MCF: 102132446(NTRK2)
CSAB: 103219672(NTRK2)
RRO: 104673903(NTRK2)
RBB: 108520515(NTRK2)
CJC: 100388984(NTRK2)
SBQ: 101053284(NTRK2)
MMU: 18212(Ntrk2)
MCAL: 110307883(Ntrk2)
MPAH: 110333600(Ntrk2)
RNO: 25054(Ntrk2)
CGE: 100754339(Ntrk2)
NGI: 103747093(Ntrk2)
HGL: 101720037(Ntrk2)
CCAN: 109677416(Ntrk2)
OCU: 100352548(NTRK2)
TUP: 102468349(NTRK2) 102497563
CFA: 484147(NTRK2)
VVP: 112908664(NTRK2)
AML: 100477127(NTRK2)
UMR: 103667631(NTRK2) 103667632
UAH: 113269802(NTRK2) 113269865
ORO: 101364921(NTRK2)
ELK: 111153613
FCA: 101101347(NTRK2)
PTG: 102950315(NTRK2)
PPAD: 109251704(NTRK2)
AJU: 106978572(NTRK2)
BTA: 505824(NTRK2)
BOM: 102269089(NTRK2)
BIU: 109563216(NTRK2)
BBUB: 102416668(NTRK2)
CHX: 102180223(NTRK2)
SSC: 100519209(NTRK2)
CFR: 102507254(NTRK2)
CDK: 105100473(NTRK2)
BACU: 103020777(NTRK2)
LVE: 103069787 103083316(NTRK2)
OOR: 101281465(NTRK2)
DLE: 111166804(NTRK2)
PCAD: 102987032(NTRK2)
ECB: 100061700(NTRK2)
EPZ: 103551809(NTRK2)
EAI: 106822031(NTRK2)
MYB: 102238774(NTRK2)
MYD: 102755544(NTRK2)
MNA: 107545009(NTRK2)
DRO: 112304477(NTRK2)
PALE: 102882910(NTRK2)
RAY: 107502751(NTRK2)
MJV: 108400418(NTRK2)
LAV: 100675363(NTRK2)
TMU: 101342178
MDO: 100029389(NTRK2)
SHR: 100927322(NTRK2)
PCW: 110194558(NTRK2)
OAA: 100080080(NTRK2)
GGA: 396157(NTRK2)
MGP: 100545915(NTRK2)
CJO: 107306253(NTRK2)
NMEL: 110389852(NTRK2)
APLA: 101797842(NTRK2)
ACYG: 106045383(NTRK2)
TGU: 751985(NTRK2)
LSR: 110472599(NTRK2)
SCAN: 103822953(NTRK2)
GFR: 102044793(NTRK2)
FAB: 101810339(NTRK2)
PHI: 102100533(NTRK2)
PMAJ: 107216220(NTRK2)
CCAE: 111940854(NTRK2)
CCW: 104692002(NTRK2)
ETL: 114055895(NTRK2)
FPG: 101919319(NTRK2)
FCH: 102055826(NTRK2)
CLV: 102092182(NTRK2)
EGZ: 104135554(NTRK2)
ACUN: 113490005(NTRK2)
PADL: 103920397(NTRK2)
AMJ: 102559730(NTRK2)
PSS: 102446411(NTRK2)
CMY: 102937131(NTRK2)
CPIC: 101947563(NTRK2) 101953939
ACS: 100558067(ntrk2)
PVT: 110089898(NTRK2)
PBI: 103063871(NTRK2)
PMUR: 107294568(NTRK2)
TSR: 106556118 106556809(NTRK2)
PMUA: 114606265(NTRK2)
GJA: 107117206(NTRK2)
XLA: 379266(ntrk2.S) 779173(ntrk2.L)
XTR: 780110(ntrk2)
NPR: 108798612(NTRK2)
DRE: 570240(ntrk2b) 65090(ntrk2a)
IPU: 108259739 108265887(ntrk2)
PHYP: 113531639 113533488(ntrk2)
AMEX: 103036414(ntrk2) 103044160
EEE: 113578767(ntrk2) 113586931
TRU: 101077811(ntrk2) 101078202
LCO: 104920263(ntrk2) 109141561
NCC: 104961592(ntrk2)
ONL: 100692708(ntrk2) 100697438
OLA: 101159930 101172248(ntrk2)
XMA: 102228507(ntrk2) 102229659
XCO: 114149964 114154115(ntrk2)
CVG: 107084447(ntrk2) 107088955
NFU: 107374736 107394032(ntrk2)
KMR: 108231044 108234558(ntrk2)
AOCE: 111564839 111567414(ntrk2)
LCF: 108873999 108878348(ntrk2)
SDU: 111230804(ntrk2) 111239875
SLAL: 111656813 111660950(ntrk2)
HCQ: 109514240(ntrk2) 109527923
BPEC: 110153486(ntrk2) 110157504
MALB: 109961608(ntrk2) 109972366
ELS: 105014455(ntrk2) 105027931
SFM: 108931316 108938645(ntrk2)
PKI: 111839208(ntrk2) 111851431
LCM: 102363882(NTRK2)
CMK: 103187358(ntrk2)
RTP: 109920280
APLC: 110977267
SKO: 100313758
TUT: 107362661
DPTE: 113794850
MYI: 110443153
OBI: 106877811
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Chen Z, Simmons MS, Perry RT, Wiener HW, Harrell LE, Go RC
  Title
Genetic association of neurotrophic tyrosine kinase receptor type 2 (NTRK2) With Alzheimer's disease.
  Journal
Am J Med Genet B Neuropsychiatr Genet 147:363-9 (2008)
DOI:10.1002/ajmg.b.30607

KEGG   ORTHOLOGY: K04527Help
Entry
K04527                      KO                                     

Name
INSR, CD220
Definition
insulin receptor [EC:2.7.10.1]
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04072  Phospholipase D signaling pathway
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04212  Longevity regulating pathway - worm
ko04213  Longevity regulating pathway - multiple species
ko04361  Axon regeneration
ko04520  Adherens junction
ko04910  Insulin signaling pathway
ko04913  Ovarian steroidogenesis
ko04923  Regulation of lipolysis in adipocytes
ko04930  Type II diabetes mellitus
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko04960  Aldosterone-regulated sodium reabsorption
Disease
H00719  Leprechaunism
H00942  Rabson-Mendenhall syndrome
H01228  Insulin-resistant diabetes mellitus with acanthosis nigricans
H01267  Familial hyperinsulinemic hypoglycemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04527  INSR, CD220; insulin receptor
   04015 Rap1 signaling pathway
    K04527  INSR, CD220; insulin receptor
   04010 MAPK signaling pathway
    K04527  INSR, CD220; insulin receptor
   04066 HIF-1 signaling pathway
    K04527  INSR, CD220; insulin receptor
   04068 FoxO signaling pathway
    K04527  INSR, CD220; insulin receptor
   04072 Phospholipase D signaling pathway
    K04527  INSR, CD220; insulin receptor
   04022 cGMP-PKG signaling pathway
    K04527  INSR, CD220; insulin receptor
   04151 PI3K-Akt signaling pathway
    K04527  INSR, CD220; insulin receptor
   04152 AMPK signaling pathway
    K04527  INSR, CD220; insulin receptor
   04150 mTOR signaling pathway
    K04527  INSR, CD220; insulin receptor
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04527  INSR, CD220; insulin receptor
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04527  INSR, CD220; insulin receptor
   04923 Regulation of lipolysis in adipocytes
    K04527  INSR, CD220; insulin receptor
   04913 Ovarian steroidogenesis
    K04527  INSR, CD220; insulin receptor
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K04527  INSR, CD220; insulin receptor
  09158 Development and regeneration
   04361 Axon regeneration
    K04527  INSR, CD220; insulin receptor
  09149 Aging
   04211 Longevity regulating pathway
    K04527  INSR, CD220; insulin receptor
   04212 Longevity regulating pathway - worm
    K04527  INSR, CD220; insulin receptor
   04213 Longevity regulating pathway - multiple species
    K04527  INSR, CD220; insulin receptor
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04527  INSR, CD220; insulin receptor
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04527  INSR, CD220; insulin receptor
   04931 Insulin resistance
    K04527  INSR, CD220; insulin receptor
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04527  INSR, CD220; insulin receptor
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K04527  INSR, CD220; insulin receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04527  INSR, CD220; insulin receptor
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  INSR family [OT]
   K04527  INSR, CD220; insulin receptor
CD molecules [BR:ko04090]
 Proteins
  K04527  CD220, INSR; insulin receptor
BRITE hierarchy
Other DBs
GO: 0005009
Genes
HSA: 3643(INSR)
PTR: 455649(INSR)
PPS: 100991905(INSR)
GGO: 101144696(INSR)
PON: 100451422(INSR)
NLE: 100597533(INSR)
MCC: 706009(INSR)
MCF: 102139081(INSR)
CSAB: 103234346(INSR)
RRO: 104679498(INSR)
RBB: 108534554(INSR)
CJC: 100403400(INSR)
SBQ: 101028986(INSR)
MMU: 16337(Insr)
MCAL: 110300622(Insr)
MPAH: 110336317(Insr)
RNO: 24954(Insr)
CGE: 100766818(Insr)
NGI: 103743312(Insr)
HGL: 101722168(Insr)
CCAN: 109694006(Insr)
OCU: 100008911(INSR)
TUP: 102469167(INSR)
CFA: 484990(INSR)
VVP: 112909702(INSR)
AML: 100473956(INSR)
UMR: 103676308(INSR)
UAH: 113242935(INSR)
ORO: 101363371(INSR)
ELK: 111161798
FCA: 100127108(INSR)
PTG: 102967156(INSR)
PPAD: 109254164(INSR)
AJU: 106979040(INSR)
BTA: 408017(INSR)
BOM: 102285317(INSR)
BIU: 109561633(INSR) 109561638
BBUB: 102391024(INSR)
CHX: 102168996(INSR)
OAS: 443431(INSR)
SSC: 396755(INSR)
CFR: 102522017(INSR)
CDK: 105087555(INSR)
BACU: 103018249(INSR)
LVE: 103085622(INSR)
OOR: 101283355(INSR)
DLE: 111165931(INSR)
PCAD: 102984092(INSR) 114485589
ECB: 100066248(INSR)
EAI: 106844524(INSR)
MYB: 102252005(INSR)
MYD: 102766590(INSR)
MNA: 107540632(INSR)
HAI: 109396062(INSR)
DRO: 112296365(INSR)
PALE: 102879346(INSR)
RAY: 107519908(INSR)
MJV: 108404652(INSR)
LAV: 100668116(INSR)
MDO: 100027215(INSR)
SHR: 100929204(INSR)
PCW: 110203364(INSR)
OAA: 100079104(INSR)
GGA: 420133(INSR)
MGP: 100550007(INSR)
CJO: 107325585(INSR)
NMEL: 110389023(INSR)
APLA: 101795803(INSR)
ACYG: 106044962(INSR)
TGU: 100228094(INSR)
LSR: 110479633(INSR)
SCAN: 103821923(INSR)
GFR: 102036061(INSR)
FAB: 101813861(INSR)
PHI: 102105828(INSR)
PMAJ: 107215564(INSR)
CCAE: 111940344(INSR)
CCW: 104696982(INSR)
ETL: 114067120 114069501(INSR)
FPG: 101914421(INSR)
FCH: 102056291(INSR)
CLV: 102085804(INSR)
EGZ: 104124372(INSR)
NNI: 104018719(INSR)
PADL: 103926439(INSR)
AAM: 106495607(INSR)
ASN: 102378715(INSR)
AMJ: 102558884(INSR)
PSS: 102459083(INSR)
CMY: 102935205(INSR)
CPIC: 101947783(INSR)
ACS: 100567954(insr) 103282842
PVT: 110072679(INSR)
PMUR: 107282222(INSR)
TSR: 106546257(INSR)
PMUA: 114588308(INSR)
GJA: 107111283 107121673(INSR)
XLA: 100158430 398006(insr.L)
XTR: 100492718(insr)
NPR: 108785893(INSR)
DRE: 245699(insra) 245700(insrb)
NCC: 104961264(insr) 104965319
XMA: 102227076 102238226(insr)
XCO: 114146472(insr) 114150578
CVG: 107094230(insr) 107100834
KMR: 108230621 108232893(insr)
AOCE: 111565521(insr) 111569056
LCM: 102345167(INSR) 102358202
CMK: 103181967(insr)
CIN: 778651
SPU: 579152
APLC: 110990313
SKO: 100329033
AGA: AgaP_AGAP012424(INR)
AME: 411297 725827(InR-2)
NVI: 100122567(INSR)
CSOL: 105359494
TCA: 661524(InR) 664271(ilr2)
BMOR: 692560(InR)
PRAP: 111003916
HAW: 110377777
TNL: 113501838
PXY: 105397590
TUT: 107365291
CSCU: 111613697
CEL: CELE_Y55D5A.5(daf-2)
CBR: CBG15732(Cbr-daf-2)
BMY: Bm1_19395
TSP: Tsp_06967
PCAN: 112553582
CRG: 105348544
MYI: 110455012
OBI: 106876722
LAK: 106153706
EPA: 110243170
AMIL: 114948463
PDAM: 113679838
SPIS: 111344627
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2859121
  Authors
Ebina Y, Ellis L, Jarnagin K, Edery M, Graf L, Clauser E, Ou JH, Masiarz F, Kan YW, Goldfine ID, et al.
  Title
The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling.
  Journal
Cell 40:747-58 (1985)
DOI:10.1016/0092-8674(85)90334-4
  Sequence
[hsa:3643]
Reference
  Authors
Youngren JF
  Title
Regulation of insulin receptor function.
  Journal
Cell Mol Life Sci 64:873-91 (2007)
DOI:10.1007/s00018-007-6359-9
  Sequence
[rno:24954]

KEGG   ORTHOLOGY: K05087Help
Entry
K05087                      KO                                     

Name
IGF1R, CD221
Definition
insulin-like growth factor 1 receptor [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04114  Oocyte meiosis
ko04140  Autophagy - animal
ko04144  Endocytosis
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04510  Focal adhesion
ko04520  Adherens junction
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04730  Long-term depression
ko04913  Ovarian steroidogenesis
ko04914  Progesterone-mediated oocyte maturation
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05205  Proteoglycans in cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
Disease
H00015  Malignant pleural mesothelioma
H00048  Hepatocellular carcinoma
H00050  Synovial sarcoma
H01274  Growth delay due to insulin-like growth factor I resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04015 Rap1 signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04010 MAPK signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04066 HIF-1 signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04068 FoxO signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04151 PI3K-Akt signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04152 AMPK signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04150 mTOR signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04140 Autophagy - animal
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09143 Cell growth and death
   04114 Oocyte meiosis
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04520 Adherens junction
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04550 Signaling pathways regulating pluripotency of stem cells
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04914 Progesterone-mediated oocyte maturation
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09156 Nervous system
   04730 Long-term depression
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09149 Aging
   04211 Longevity regulating pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04213 Longevity regulating pathway - multiple species
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05202 Transcriptional misregulation in cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05205 Proteoglycans in cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05214 Glioma
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05218 Melanoma
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05215 Prostate cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05224 Breast cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   01522 Endocrine resistance
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  INSR family [OT]
   K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
CD molecules [BR:ko04090]
 Proteins
  K05087  CD221, IGF1R; insulin-like growth factor 1 receptor
BRITE hierarchy
Other DBs
GO: 0005010 0031994
Genes
HSA: 3480(IGF1R)
PTR: 453676(IGF1R)
PPS: 100981083(IGF1R)
GGO: 101154546(IGF1R)
PON: 100172156(IGF1R)
NLE: 100593288(IGF1R)
MCC: 708227(IGF1R)
MCF: 102130142(IGF1R)
CSAB: 103231259(IGF1R)
RRO: 104677192(IGF1R)
RBB: 108538668(IGF1R)
CJC: 100408399(IGF1R)
SBQ: 101039763(IGF1R)
MMU: 16001(Igf1r)
MCAL: 110297825(Igf1r)
MPAH: 110324292(Igf1r)
RNO: 25718(Igf1r)
MUN: 110547261(Igf1r)
CGE: 100768531(Igf1r)
NGI: 103749467(Igf1r)
HGL: 101710224(Igf1r)
OCU: 100144342(IGF1R)
TUP: 102473496(IGF1R)
CFA: 442951(IGF1R)
VVP: 112922150(IGF1R)
AML: 100471374(IGF1R)
UAH: 113263646(IGF1R)
ORO: 101386211(IGF1R)
ELK: 111152643
FCA: 100500937(IGF1R)
PTG: 102949680(IGF1R) 102949974
PPAD: 109273360(IGF1R)
AJU: 106975144(IGF1R)
BTA: 281848(IGF1R)
BOM: 102278105(IGF1R)
BBUB: 102403092(IGF1R)
CHX: 100861165(IGF1R)
OAS: 443515(IGF1R)
SSC: 397350(IGF1R)
CFR: 102524338(IGF1R)
CDK: 105093441(IGF1R) 105106700
BACU: 103015537(IGF1R)
LVE: 103081291(IGF1R)
OOR: 101281976(IGF1R)
DLE: 111187347(IGF1R)
PCAD: 102977826(IGF1R)
ECB: 100055698(IGF1R)
EPZ: 103559577(IGF1R)
EAI: 106836604(IGF1R)
MYB: 102253516(IGF1R)
MYD: 102770795(IGF1R)
MNA: 107527774(IGF1R)
HAI: 109380372(IGF1R)
DRO: 112306076(IGF1R)
PALE: 102885962(IGF1R)
MJV: 108401879 108403280(IGF1R)
LAV: 100655087(IGF1R)
MDO: 100020095(IGF1R)
SHR: 100916673(IGF1R)
PCW: 110192705(IGF1R)
OAA: 100077556(IGF1R)
GGA: 395889(IGF1R)
MGP: 100539720(IGF1R)
CJO: 107318870(IGF1R)
NMEL: 110403525(IGF1R)
APLA: 101802018(IGF1R)
ACYG: 106036418(IGF1R)
TGU: 100227374(IGF1R)
LSR: 110482986(IGF1R)
SCAN: 103816222(IGF1R)
GFR: 102036037(IGF1R)
FAB: 101819893(IGF1R)
PHI: 102103364(IGF1R)
PMAJ: 107209439(IGF1R)
CCAE: 111933868(IGF1R)
CCW: 104684080(IGF1R)
ETL: 114054644(IGF1R)
FPG: 101914715(IGF1R)
FCH: 102046128(IGF1R)
CLV: 102089963(IGF1R)
EGZ: 104122851(IGF1R) 104122875
NNI: 104017228(IGF1R)
ACUN: 113483985(IGF1R)
PADL: 103914830(IGF1R)
AAM: 106485327(IGF1R)
ASN: 102387852(IGF1R)
AMJ: 106736787(IGF1R)
PSS: 102455576(IGF1R)
CMY: 102941686(IGF1R)
CPIC: 101952328(IGF1R)
ACS: 100554064(igf1r)
PVT: 110072986(IGF1R)
PBI: 103049336(IGF1R)
PMUR: 107290589(IGF1R)
TSR: 106545511(IGF1R) 106555187
PMUA: 114584984(IGF1R)
GJA: 107121607(IGF1R)
XLA: 108711478(igf1r.L) 398022(igf1r.S)
XTR: 100329112(igf1r)
NPR: 108787513(IGF1R)
DRE: 245701(igf1ra) 245702(igf1rb)
IPU: 100304999(igf1r) 108271091(Igf1r)
PHYP: 113534424(igf1r) 113536568
LCO: 104920736(igf1r) 104921706
MZE: 101469217 101479543(igf1r)
CSEM: 103379307
POV: 109624556 109625052(igf1r)
HCQ: 109513166 109513874(igf1r)
ELS: 105016672 105023472(igf1r)
SFM: 108926605(igf1r) 108941092
PKI: 111845000(igf1r) 111845734
LCM: 102367342(IGF1R)
CMK: 103188389(igf1r)
DME: Dmel_CG18402(InR)
DER: 6553414
DSI: Dsimw501_GD19971(Dsim_GD19971)
DSR: 110188261
DPE: 6591473
DMN: 108155588
DWI: 6647111
DAZ: 108621684
DNV: 108660316
DHE: 111600855
MDE: 101894251
LCQ: 111677709
HAW: 110369826
TNL: 113496051
TSP: Tsp_12077
HMG: 100214733(HTK7)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8257688
  Authors
Kasuya J, Paz IB, Maddux BA, Goldfine ID, Hefta SA, Fujita-Yamaguchi Y
  Title
Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification.
  Journal
Biochemistry 32:13531-6 (1993)
DOI:10.1021/bi00212a019
  Sequence
[hsa:3480]
Reference
PMID:2877871
  Authors
Ullrich A, Gray A, Tam AW, Yang-Feng T, Tsubokawa M, Collins C, Henzel W, Le Bon T, Kathuria S, Chen E, et al.
  Title
Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.
  Journal
EMBO J 5:2503-12 (1986)
  Sequence
[hsa:3480]
Reference
  Authors
Siddle K, Urso B, Niesler CA, Cope DL, Molina L, Surinya KH, Soos MA
  Title
Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors.
  Journal
Biochem Soc Trans 29:513-25 (2001)
DOI:10.1042/bst0290513

KEGG   ORTHOLOGY: K04363Help
Entry
K04363                      KO                                     

Name
PDGFRA, CD140A
Definition
platelet-derived growth factor receptor alpha [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04072  Phospholipase D signaling pathway
ko04144  Endocytosis
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04540  Gap junction
ko04630  JAK-STAT signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05163  Human cytomegalovirus infection
ko05200  Pathways in cancer
ko05206  MicroRNAs in cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
Disease
H00042  Glioma
H01590  Chronic eosinophilic leukemia
H01591  Gastrotintestinal stromal tumor
H01599  Hypereosinophilic syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04015 Rap1 signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04010 MAPK signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04630 Jak-STAT signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04020 Calcium signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04072 Phospholipase D signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04151 PI3K-Akt signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04540 Gap junction
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05206 MicroRNAs in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05230 Central carbon metabolism in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05231 Choline metabolism in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09162 Cancer: specific types
   05214 Glioma
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05218 Melanoma
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05215 Prostate cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
CD molecules [BR:ko04090]
 Proteins
  K04363  CD140a, PDGFRA; platelet-derived growth factor receptor, alpha polypeptide
BRITE hierarchy
Other DBs
GO: 0005018
Genes
HSA: 5156(PDGFRA)
PTR: 461318(PDGFRA)
PPS: 100982337(PDGFRA)
GGO: 101124928(PDGFRA)
PON: 100431735(PDGFRA)
NLE: 100603207(PDGFRA)
MCC: 697002(PDGFRA)
MCF: 102138392(PDGFRA)
CSAB: 103235675(PDGFRA)
RRO: 104658857(PDGFRA)
RBB: 108533750(PDGFRA)
CJC: 100412331(PDGFRA)
SBQ: 101040156(PDGFRA)
MMU: 18595(Pdgfra)
MCAL: 110295292(Pdgfra)
MPAH: 110331028(Pdgfra)
RNO: 25267(Pdgfra)
MUN: 110558105(Pdgfra)
CGE: 100760258(Pdgfra)
NGI: 103734393(Pdgfra)
HGL: 101697360(Pdgfra)
CCAN: 109685094(Pdgfra) 109702274
OCU: 100343006(PDGFRA)
TUP: 102488187(PDGFRA)
CFA: 442860(PDGFRA)
VVP: 112933353(PDGFRA)
AML: 100464991(PDGFRA)
UMR: 103672737(PDGFRA)
UAH: 113262493(PDGFRA)
ORO: 101372359(PDGFRA)
ELK: 111148924
FCA: 101090765(PDGFRA)
PTG: 102955481(PDGFRA)
PPAD: 109278988(PDGFRA)
AJU: 106983998(PDGFRA)
BTA: 282301(PDGFRA)
BOM: 102282598(PDGFRA)
BIU: 109560475(PDGFRA)
BBUB: 102409620(PDGFRA)
CHX: 102174007(PDGFRA)
OAS: 101106012(PDGFRA)
SSC: 100627123(PDGFRA)
CFR: 102512589(PDGFRA)
CDK: 105103397(PDGFRA)
BACU: 102998016(PDGFRA)
LVE: 103071473(PDGFRA)
OOR: 101269459(PDGFRA)
DLE: 111169692(PDGFRA)
PCAD: 102994349(PDGFRA)
ECB: 100059815(PDGFRA)
EPZ: 103552305(PDGFRA)
EAI: 106839051(PDGFRA)
MYB: 102255326(PDGFRA)
MYD: 102761943(PDGFRA)
MNA: 107532710(PDGFRA)
HAI: 109381815(PDGFRA)
DRO: 112316918(PDGFRA)
PALE: 102895362(PDGFRA)
RAY: 107499793(PDGFRA)
MJV: 108385741(PDGFRA)
LAV: 100670735(PDGFRA)
TMU: 101348884
MDO: 100013088(PDGFRA)
SHR: 100925116(PDGFRA)
PCW: 110200158(PDGFRA)
OAA: 100084432(PDGFRA)
GGA: 395509(PDGFRA)
MGP: 100542010(PDGFRA)
CJO: 107313741(PDGFRA)
NMEL: 110397725(PDGFRA)
APLA: 101797285(PDGFRA)
ACYG: 106030788(PDGFRA)
TGU: 100218386(PDGFRA)
LSR: 110469831(PDGFRA)
SCAN: 103825217(PDGFRA)
GFR: 102044274(PDGFRA)
FAB: 101820996(PDGFRA)
PHI: 102113476(PDGFRA)
PMAJ: 107203533(PDGFRA)
CCAE: 111928019(PDGFRA)
CCW: 104690630(PDGFRA)
ETL: 114058301(PDGFRA)
FPG: 101913531(PDGFRA)
FCH: 102054310(PDGFRA)
CLV: 102087625(PDGFRA)
EGZ: 104129386(PDGFRA)
NNI: 104020776(PDGFRA)
ACUN: 113479434(PDGFRA)
PADL: 103926287(PDGFRA)
AAM: 106490172(PDGFRA)
ASN: 102378120(PDGFRA)
AMJ: 102575338(PDGFRA)
PSS: 102443708(PDGFRA)
CMY: 102935642(PDGFRA)
CPIC: 101935558(PDGFRA)
ACS: 100565834(pdgfra) 103278978
PVT: 110078407(PDGFRA)
PBI: 103067713(PDGFRA)
PMUR: 107298631(PDGFRA)
TSR: 106547777
PMUA: 114604335(PDGFRA)
GJA: 107106036(PDGFRA)
XLA: 108706592(pdgfra.S) 380245(pdgfra.L)
XTR: 100124862(pdgfra)
NPR: 108804111(PDGFRA)
DRE: 386856(pdgfra)
CCAR: 109112741
IPU: 108258040(pdgfra)
PHYP: 113546841(pdgfra)
AMEX: 103044267(pdgfra)
EEE: 113586382(pdgfra)
TRU: 101073543(pdgfra)
LCO: 104919088(pdgfra)
NCC: 104947073(pdgfra)
MZE: 101471693(pdgfra)
ONL: 100692594(pdgfra)
OLA: 100049280(pdgfra)
XMA: 102219876(pdgfra)
XCO: 114151105(pdgfra)
PRET: 103463840(pdgfra)
CVG: 107091563(pdgfra)
NFU: 107393382(pdgfra)
KMR: 108243392(pdgfra)
ALIM: 106524096(pdgfra)
AOCE: 111569607(pdgfra)
CSEM: 103376707(pdgfra)
POV: 109625664(pdgfra)
LCF: 108879100(pdgfra)
SDU: 111226338(pdgfra)
SLAL: 111644345(pdgfra)
HCQ: 109532287(pdgfra)
BPEC: 110154688(pdgfra)
MALB: 109962087(pdgfra)
SASA: 106560269 106584117(pdgfra)
SALP: 111972315(pdgfra) 111976174
ELS: 105011836(pdgfra)
SFM: 108922803(pdgfra)
LCM: 102353753(PDGFRA)
CMK: 103178167(pdgfra)
RTP: 109926227 109927411(pdgfra)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2544881
  Authors
Claesson-Welsh L, Eriksson A, Westermark B, Heldin CH
  Title
cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor.
  Journal
Proc Natl Acad Sci U S A 86:4917-21 (1989)
DOI:10.1073/pnas.86.13.4917
  Sequence
[hsa:5156]
Reference
PMID:8188664
  Authors
Vassbotn FS, Havnen OK, Heldin CH, Holmsen H
  Title
Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor.
  Journal
J Biol Chem 269:13874-9 (1994)
  Sequence
[hsa:5156]

KEGG   ORTHOLOGY: K05089Help
Entry
K05089                      KO                                     

Name
PDGFRB, CD140B
Definition
platelet-derived growth factor receptor beta [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04072  Phospholipase D signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04540  Gap junction
ko04630  JAK-STAT signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05206  MicroRNAs in cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
Disease
H00042  Glioma
H01574  Familial idiopathic basal ganglia calcification
H01910  Infantile myofibromatosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04015 Rap1 signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04010 MAPK signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04630 Jak-STAT signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04020 Calcium signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04072 Phospholipase D signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04151 PI3K-Akt signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04540 Gap junction
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05206 MicroRNAs in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05230 Central carbon metabolism in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05231 Choline metabolism in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09162 Cancer: specific types
   05214 Glioma
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05218 Melanoma
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05215 Prostate cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
CD molecules [BR:ko04090]
 Proteins
  K05089  CD140b, PDGFRB; platelet-derived growth factor receptor, beta polypeptide
BRITE hierarchy
Other DBs
GO: 0004992
Genes
HSA: 5159(PDGFRB)
PTR: 462188(PDGFRB)
PPS: 100975853(PDGFRB)
GGO: 101150577(PDGFRB)
PON: 100460001(PDGFRB)
NLE: 100597894(PDGFRB)
MCC: 711353(PDGFRB)
MCF: 101867161(PDGFRB)
CSAB: 103244790(PDGFRB)
RRO: 104670408(PDGFRB)
RBB: 108532047(PDGFRB)
CJC: 100389852(PDGFRB)
SBQ: 101040158(PDGFRB)
MMU: 18596(Pdgfrb)
MCAL: 110284880(Pdgfrb)
MPAH: 110333065(Pdgfrb)
RNO: 24629(Pdgfrb)
MUN: 110546695(Pdgfrb)
CGE: 100764374(Pdgfrb)
NGI: 103747076(Pdgfrb)
HGL: 101721151(Pdgfrb)
CCAN: 109685664(Pdgfrb) 109685672
OCU: 100342872(PDGFRB)
TUP: 102492413(PDGFRB)
CFA: 442985(PDGFRB)
VVP: 112927357(PDGFRB)
AML: 100472005(PDGFRB)
UMR: 103664600(PDGFRB)
UAH: 113263944(PDGFRB)
ORO: 101374793(PDGFRB)
ELK: 111140848
FCA: 101084600(PDGFRB)
PTG: 102954207(PDGFRB)
PPAD: 109275948(PDGFRB)
AJU: 106985388(PDGFRB)
BTA: 527165(PDGFRB)
BOM: 102270608(PDGFRB)
BIU: 109562197(PDGFRB)
BBUB: 102392216(PDGFRB)
CHX: 102184426(PDGFRB)
OAS: 101122783(PDGFRB)
SSC: 102166564(PDGFRB)
CFR: 102512951(PDGFRB)
CDK: 105098486(PDGFRB)
BACU: 103019883(PDGFRB)
LVE: 103082363(PDGFRB)
OOR: 101272795(PDGFRB)
DLE: 111183086(PDGFRB)
PCAD: 102995915(PDGFRB)
ECB: 100071665(PDGFRB)
EPZ: 103549125(PDGFRB)
EAI: 106838493(PDGFRB)
MYB: 102241145(PDGFRB)
MYD: 102764172(PDGFRB)
MNA: 107535230(PDGFRB)
HAI: 109375002(PDGFRB)
DRO: 112319577(PDGFRB)
PALE: 102887643(PDGFRB)
RAY: 107497163(PDGFRB)
MJV: 108385397(PDGFRB)
LAV: 100671240(PDGFRB)
TMU: 101360003
MDO: 100028943(PDGFRB)
SHR: 100917212(PDGFRB)
PCW: 110192821(PDGFRB)
OAA: 100079459(PDGFRB)
GGA: 770488(PDGFRB)
MGP: 100550611(PDGFRB)
CJO: 107320191(PDGFRB)
NMEL: 110405265(PDGFRB)
APLA: 101799587(PDGFRB)
ACYG: 106032823(PDGFRB)
TGU: 100223375(PDGFRB)
LSR: 110482721(PDGFRB)
SCAN: 103817301(PDGFRB)
GFR: 102045343(PDGFRB)
FAB: 101809926(PDGFRB)
PHI: 102111524(PDGFRB)
PMAJ: 107210844(PDGFRB)
CCAE: 111935543(PDGFRB)
CCW: 104689579(PDGFRB)
ETL: 114063193(PDGFRB)
FPG: 101918438(PDGFRB)
FCH: 102052718(PDGFRB)
CLV: 102096790(PDGFRB)
EGZ: 104123312(PDGFRB)
NNI: 104014196(PDGFRB)
ACUN: 113485173(PDGFRB)
PADL: 103915745(PDGFRB)
AAM: 106493441(PDGFRB)
ASN: 102372962(PDGFRB)
AMJ: 102566175(PDGFRB)
PSS: 102460895(PDGFRB)
CMY: 102944650(PDGFRB)
CPIC: 101940553(PDGFRB)
ACS: 100555784(pdgfrb)
PVT: 110086089(PDGFRB)
PBI: 103051588(PDGFRB)
TSR: 106547766(PDGFRB)
PMUA: 114591343(PDGFRB)
GJA: 107116322(PDGFRB) 107123329
XLA: 108712643(pdgfrb.S)
XTR: 100487523(pdgfrb)
NPR: 108785807(PDGFRB)
DRE: 559529(pdgfrb)
IPU: 108274697(pdgfrb)
PHYP: 113529620(pdgfrb)
AMEX: 103036483
EEE: 113575581(pdgfrb)
TRU: 101061130 101074724(pdgfrb)
NCC: 104965701(pdgfrb)
MZE: 101466822 101484671(pdgfrb)
ONL: 100695603(pdgfrb) 100709470
OLA: 101155039(pdgfrb) 101156428
XMA: 102229755 102233464(pdgfrb)
XCO: 114139478(pdgfrb) 114153115
PRET: 103459902 103471279(pdgfrb)
CVG: 107095000(pdgfrb) 107102292
NFU: 107375657(pdgfrb)
ALIM: 106517359(pdgfrb) 106532997
AOCE: 111569523(pdgfrb) 111575719
CSEM: 103391002(pdgfrb) 103392104
POV: 109626437(pdgfrb) 109647502
LCF: 108873646 108899186(pdgfrb)
SDU: 111226471(pdgfrb) 111239485
HCQ: 109518748(pdgfrb) 109528881
SFM: 108936824(pdgfrb)
PKI: 111855164(pdgfrb)
LCM: 102361386(PDGFRB)
CMK: 103188232(pdgfrb)
RTP: 109924570
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Jones AV, Cross NC
  Title
Oncogenic derivatives of platelet-derived growth factor receptors.
  Journal
Cell Mol Life Sci 61:2912-23 (2004)
DOI:10.1007/s00018-004-4272-z
Reference
PMID:2835772
  Authors
Gronwald RG, Grant FJ, Haldeman BA, Hart CE, O'Hara PJ, Hagen FS, Ross R, Bowen-Pope DF, Murray MJ
  Title
Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class.
  Journal
Proc Natl Acad Sci U S A 85:3435-9 (1988)
DOI:10.1073/pnas.85.10.3435
  Sequence
[hsa:5159]

KEGG   ORTHOLOGY: K05090Help
Entry
K05090                      KO                                     

Name
CSF1R, FMS, CD115
Definition
macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04061  Viral protein interaction with cytokine and cytokine receptor
ko04151  PI3K-Akt signaling pathway
ko04380  Osteoclast differentiation
ko04640  Hematopoietic cell lineage
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05221  Acute myeloid leukemia
Disease
H00028  Choriocarcinoma
H01807  Hereditary diffuse leukoencephalopathy with spheroids
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
   04015 Rap1 signaling pathway
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
   04010 MAPK signaling pathway
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
   04151 PI3K-Akt signaling pathway
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
   05202 Transcriptional misregulation in cancer
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
CD molecules [BR:ko04090]
 Proteins
  K05090  CD115, CSF1R; colony stimulating factor 1 receptor
BRITE hierarchy
Genes
HSA: 1436(CSF1R)
PTR: 462187(CSF1R)
PPS: 100974967(CSF1R)
GGO: 101151662(CSF1R)
PON: 100433386(CSF1R)
NLE: 100598906(CSF1R)
MCC: 711512(CSF1R)
MCF: 102124214(CSF1R)
CSAB: 103244788(CSF1R)
RRO: 104670407(CSF1R)
RBB: 108532049(CSF1R)
CJC: 100406047(CSF1R)
SBQ: 101043573(CSF1R)
MMU: 12978(Csf1r)
MCAL: 110285184(Csf1r)
MPAH: 110333327(Csf1r)
RNO: 307403(Csf1r)
MUN: 110546688(Csf1r)
CGE: 100763221(Csf1r)
NGI: 103747075(Csf1r)
HGL: 101719513(Csf1r)
CCAN: 109683164(Csf1r) 109685629
OCU: 100340992(CSF1R)
TUP: 102491581(CSF1R)
CFA: 489188(CSF1R)
VVP: 112927384(CSF1R)
AML: 100472252(CSF1R)
UMR: 103664603(CSF1R)
UAH: 113263940(CSF1R)
ORO: 101374504(CSF1R)
ELK: 111140850
FCA: 493706(CSF1R)
PTG: 102953056(CSF1R)
PPAD: 109275945(CSF1R)
AJU: 106985394(CSF1R)
BTA: 509418(CSF1R)
BOM: 102272280(CSF1R)
BIU: 109562194(CSF1R)
BBUB: 102414145(CSF1R)
CHX: 100861303(CSF1R)
OAS: 101109969(CSF1R)
SSC: 100517086(CSF1R)
CFR: 102513202(CSF1R)
CDK: 105098488(CSF1R)
BACU: 102999126(CSF1R)
LVE: 103075680(CSF1R)
OOR: 101273049(CSF1R)
DLE: 111183085(CSF1R)
PCAD: 102996862 114486804(CSF1R)
ECB: 100060422(CSF1R)
EAI: 106838490(CSF1R)
MYB: 102256301(CSF1R)
MYD: 102763897(CSF1R)
MNA: 107535231(CSF1R)
HAI: 109374995(CSF1R)
DRO: 112319552(CSF1R)
PALE: 102886964(CSF1R)
RAY: 107513557(CSF1R)
MJV: 108385396(CSF1R)
LAV: 100670956(CSF1R)
TMU: 101360266
MDO: 100028926(CSF1R)
SHR: 100916950(CSF1R)
PCW: 110192877(CSF1R)
OAA: 100079755(CSF1R)
GGA: 396406(CSF1R)
MGP: 100549842(CSF1R)
CJO: 107320150(CSF1R)
NMEL: 110405187(CSF1R)
APLA: 101802224(CSF1R)
ACYG: 106032822(CSF1R)
TGU: 100220482(CSF1R)
LSR: 110482754(CSF1R)
SCAN: 103817300(CSF1R)
GFR: 102045177(CSF1R)
FAB: 101809748(CSF1R)
PHI: 102111338(CSF1R)
PMAJ: 107210711(CSF1R)
CCAE: 111935546(CSF1R)
CCW: 104689582(CSF1R)
ETL: 114063183(CSF1R)
FPG: 101918260(CSF1R)
FCH: 102052893(CSF1R)
CLV: 102090039(CSF1R)
EGZ: 104123541(CSF1R)
NNI: 104014195(CSF1R)
ACUN: 113485362(CSF1R)
PADL: 103915746(CSF1R)
AAM: 106493440(CSF1R)
ASN: 102373216(CSF1R)
AMJ: 102565932(CSF1R)
PSS: 102460494(CSF1R)
CMY: 102937993(CSF1R)
CPIC: 101940831(CSF1R)
ACS: 100555979(csf1r)
PVT: 110086091(CSF1R)
PBI: 103051818(CSF1R)
PMUR: 107298558(CSF1R) 107300232
TSR: 106547767(CSF1R)
PMUA: 114591344(CSF1R)
GJA: 107116323(CSF1R)
XLA: 101243554(csf1r)
XTR: 493543(csf1r)
NPR: 108785796(CSF1R)
DRE: 568405(csf1rb) 64274(csf1ra)
IPU: 100526732(csf1r) 108278893
PHYP: 113524593 113529571(csf1r)
EEE: 113575551(csf1r) 113587446
TRU: 101069994(csf1r) 101080143
NCC: 104965699(csf1r)
MZE: 101466356 101484032(csf1r)
ONL: 100709907(csf1r) 100710555
PRET: 103459904(csf1r) 103471278(csf1r)
NFU: 107375663 107387189(csf1r)
KMR: 108228290 108240545(csf1r)
ALIM: 106517374(csf1r) 106532555
AOCE: 111569513(csf1r) 111575718
CSEM: 103391009(csf1r) 103395736
POV: 109626445(csf1r) 109642209
LCF: 108873645 108899187(csf1r)
SDU: 111226429(csf1r) 111239498
HCQ: 109518749(csf1r) 109528889
SFM: 108934464 108936825(csf1r)
LCM: 102349790(CSF1R)
CMK: 103188221
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2421165
  Authors
Coussens L, Van Beveren C, Smith D, Chen E, Mitchell RL, Isacke CM, Verma IM, Ullrich A
  Title
Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus.
  Journal
Nature 320:277-80 (1986)
DOI:10.1038/320277a0
  Sequence
[hsa:1436]
Reference
PMID:9262961
  Authors
Fixe P, Praloran V
  Title
Macrophage colony-stimulating-factor (M-CSF or CSF-1) and its receptor: structure-function relationships.
  Journal
Eur Cytokine Netw 8:125-36 (1997)

KEGG   ORTHOLOGY: K05091Help
Entry
K05091                      KO                                     

Name
KIT, SCFR, CD117
Definition
proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04072  Phospholipase D signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04640  Hematopoietic cell lineage
ko04916  Melanogenesis
ko05200  Pathways in cancer
ko05221  Acute myeloid leukemia
ko05224  Breast cancer
ko05230  Central carbon metabolism in cancer
Disease
H00003  Acute myeloid leukemia
H00031  Breast cancer
H00170  Piebaldism
H01359  Anaphylaxis
H01511  Mast-cell leukemia
H01591  Gastrotintestinal stromal tumor
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   04015 Rap1 signaling pathway
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   04010 MAPK signaling pathway
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   04072 Phospholipase D signaling pathway
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   04151 PI3K-Akt signaling pathway
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
  09152 Endocrine system
   04916 Melanogenesis
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   05230 Central carbon metabolism in cancer
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   05224 Breast cancer
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
CD molecules [BR:ko04090]
 Proteins
  K05091  CD117, KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
BRITE hierarchy
Genes
HSA: 3815(KIT)
PTR: 461316(KIT)
PPS: 100985935(KIT)
GGO: 101126389(KIT)
PON: 100437110(KIT)
NLE: 100603893(KIT)
MCC: 696759(KIT)
MCF: 102137242(KIT)
CSAB: 103235672(KIT)
RRO: 104658855(KIT)
RBB: 108533749(KIT)
CJC: 100411615(KIT)
SBQ: 101037282(KIT)
MMU: 16590(Kit)
MCAL: 110294693(Kit)
MPAH: 110330230(Kit)
RNO: 64030(Kit)
MUN: 110565064(Kit)
CGE: 100751027(Kit)
NGI: 103734391(Kit)
HGL: 101726400(Kit)
CCAN: 109698965(Kit)
OCU: 100327263(KIT)
TUP: 102489301(KIT)
CFA: 403811(KIT)
AML: 100465243(KIT)
UMR: 103672804(KIT)
UAH: 113262502(KIT)
ORO: 101372059(KIT)
ELK: 111148912
FCA: 493766(KIT)
PTG: 102960767(KIT)
PPAD: 109278960(KIT)
AJU: 106983989(KIT)
BTA: 280832(KIT)
BOM: 102272986(KIT)
BIU: 109560477(KIT)
BBUB: 102410945(KIT)
CHX: 100861386(KIT)
OAS: 780504(KIT)
SSC: 396810(KIT)
CFR: 102521127(KIT)
CDK: 105091541(KIT)
BACU: 102999027(KIT)
LVE: 103070834(KIT)
OOR: 101269214(KIT)
DLE: 111169672(KIT)
PCAD: 102985479(KIT)
ECB: 100009704(KIT)
EPZ: 103554972(KIT)
EAI: 106839052(KIT)
MYB: 102263655(KIT)
MYD: 102761085(KIT)
MNA: 107532733(KIT)
HAI: 109381816(KIT)
DRO: 112316812(KIT)
PALE: 102895969(KIT)
RAY: 107499790(KIT)
MJV: 108391899(KIT)
LAV: 100655943(KIT)
TMU: 101357486
MDO: 100017501(KIT)
SHR: 100929346(KIT)
PCW: 110200157(KIT)
OAA: 100075317(KIT)
GGA: 378783(KIT)
MGP: 100542786(KIT)
CJO: 107313766(KIT)
NMEL: 110398600(KIT)
APLA: 101796083(KIT)
ACYG: 106030824(KIT)
TGU: 100221238(KIT)
LSR: 110470402(KIT)
SCAN: 103826188(KIT)
GFR: 102042215(KIT)
FAB: 101812754(KIT)
PHI: 102103717(KIT)
PMAJ: 107203543(KIT)
CCAE: 111928444(KIT)
CCW: 104690629(KIT)
ETL: 114058322(KIT)
FPG: 101920758(KIT)
FCH: 102058936(KIT)
CLV: 102095499(KIT)
EGZ: 104129461(KIT)
NNI: 104020818(KIT)
ACUN: 113479223(KIT)
PADL: 103926350(KIT)
AAM: 106490087(KIT)
ASN: 102378355(KIT)
AMJ: 102573437(KIT)
PSS: 102451068(KIT)
CMY: 102935862(KIT)
CPIC: 101936545(KIT)
ACS: 100551543(kit)
PVT: 110078419(KIT)
PBI: 103064280(KIT)
PMUR: 107294049(KIT) 107300999
PMUA: 114604149(KIT)
GJA: 107106035(KIT)
XLA: 373579(kit.L) 373727(g67.L) 373772(kit.S)
XTR: 100216090(kit)
NPR: 108803804(KIT)
DRE: 30256(kita) 497629(kitb)
IPU: 108258027(kit) 108260969
PHYP: 113544438 113546833(kit)
AMEX: 103022298(kit) 103024973
EEE: 113586384(kit) 113591595
TRU: 101073765(kit) 101078652
NCC: 104947075(kit) 104968028
MZE: 101472356(kit) 101477603
ONL: 100692323(kit) 100706409
OLA: 101161964(kit) 101164953
XMA: 102225575(kit) 102237809
XCO: 114144177 114151106(kit)
PRET: 103463839(kit) 103468941
CVG: 107091570(kit) 107093495
NFU: 107382191 107393389(kit)
KMR: 108241514 108243393(kit)
AOCE: 111569601(kit) 111569809
CSEM: 103376706(kit) 103383759
POV: 109625665(kit) 109637735
SDU: 111226336(kit) 111231521
SLAL: 111644342(kit) 111664577
HCQ: 109511237 109532261(kit)
BPEC: 110154760(kit) 110172572
SALP: 111972317(kit) 111976175
ELS: 105011837(kit) 105020866
SFM: 108922805(kit)
PKI: 111850065(kit)
LCM: 102363945(KIT)
CMK: 103178222(kit)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2448137
  Authors
Yarden Y, Kuang WJ, Yang-Feng T, Coussens L, Munemitsu S, Dull TJ, Chen E, Schlessinger J, Francke U, Ullrich A
  Title
Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.
  Journal
EMBO J 6:3341-51 (1987)
  Sequence
[hsa:3815]
Reference
  Authors
Roskoski R Jr
  Title
Structure and regulation of Kit protein-tyrosine kinase--the stem cell factor receptor.
  Journal
Biochem Biophys Res Commun 338:1307-15 (2005)
DOI:10.1016/j.bbrc.2005.09.150
Reference
PMID:1698611
  Authors
Nocka K, Buck J, Levi E, Besmer P
  Title
Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors.
  Journal
EMBO J 9:3287-94 (1990)
  Sequence
[mmu:16590]

KEGG   ORTHOLOGY: K05092Help
Entry
K05092                      KO                                     

Name
FLT3, FLK2, CD135
Definition
fms-related tyrosine kinase 3 [EC:2.7.10.1]
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04640  Hematopoietic cell lineage
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05221  Acute myeloid leukemia
ko05230  Central carbon metabolism in cancer
Disease
H00003  Acute myeloid leukemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
   04010 MAPK signaling pathway
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
   04151 PI3K-Akt signaling pathway
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
   05202 Transcriptional misregulation in cancer
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
   05230 Central carbon metabolism in cancer
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
CD molecules [BR:ko04090]
 Proteins
  K05092  CD135, FLT3; fms-related tyrosine kinase 3
BRITE hierarchy
Genes
HSA: 2322(FLT3)
PTR: 452508(FLT3)
PPS: 100989601(FLT3)
GGO: 101131781(FLT3)
PON: 100454731(FLT3)
NLE: 100589184(FLT3)
MCC: 721712(FLT3)
MCF: 102144988(FLT3)
CSAB: 103249072(FLT3)
RRO: 104661678(FLT3)
RBB: 108512945(FLT3)
CJC: 100413316(FLT3)
SBQ: 101027591(FLT3)
MMU: 14255(Flt3)
MCAL: 110294537(Flt3)
MPAH: 110312926(Flt3)
RNO: 140635(Flt3)
CGE: 100761902(Flt3)
NGI: 103727235(Flt3)
HGL: 101713724(Flt3)
CCAN: 109694695(Flt3)
OCU: 108175474(FLT3)
TUP: 106733545(FLT3)
CFA: 486025(FLT3)
VVP: 112918638(FLT3)
AML: 100483963(FLT3)
UMR: 103664318(FLT3)
UAH: 113251210(FLT3)
ORO: 101382975(FLT3)
ELK: 111158528
FCA: 101099264(FLT3)
PTG: 102955843(FLT3)
PPAD: 109266125(FLT3)
AJU: 106985565(FLT3)
BTA: 512700(FLT3)
BOM: 102272113(FLT3)
BIU: 109567013(FLT3)
BBUB: 102402092(FLT3)
CHX: 102189319(FLT3)
OAS: 101112331(FLT3)
SSC: 100515445(FLT3)
CFR: 102508422(FLT3)
CDK: 105086582(FLT3)
BACU: 103008462(FLT3)
LVE: 103080479(FLT3)
OOR: 101278112(FLT3)
DLE: 111175185(FLT3)
PCAD: 102989448(FLT3)
ECB: 100061780(FLT3)
EPZ: 103562043(FLT3)
EAI: 106832906(FLT3)
MYB: 102244263(FLT3)
MYD: 102760103(FLT3)
MNA: 107534352(FLT3)
HAI: 109395206(FLT3)
DRO: 112323198(FLT3)
PALE: 102891572(FLT3)
RAY: 107514324(FLT3)
MJV: 108407453(FLT3)
LAV: 100668366(FLT3)
TMU: 101352048
MDO: 100025262(FLT3)
SHR: 100929912(FLT3) 111720208
PCW: 110215617(FLT3)
OAA: 100090467(FLT3)
GGA: 100858422(FLT3)
MGP: 100542111(FLT3)
CJO: 107308287(FLT3)
NMEL: 110388941(FLT3)
APLA: 101794861(FLT3)
ACYG: 106041163(FLT3)
TGU: 100230451(FLT3)
LSR: 110476711(FLT3)
SCAN: 103812551(FLT3)
GFR: 102039519(FLT3)
FAB: 101807614(FLT3)
PHI: 102112465(FLT3)
PMAJ: 107213698(FLT3)
CCAE: 111923247(FLT3)
CCW: 104689892(FLT3)
ETL: 114067515(FLT3)
FPG: 101924556(FLT3)
FCH: 102052010(FLT3)
CLV: 102092160(FLT3)
EGZ: 104133700(FLT3)
NNI: 104023083(FLT3)
ACUN: 113486345(FLT3)
PADL: 103920186(FLT3)
AAM: 106500428(FLT3)
ASN: 102372238(FLT3)
AMJ: 102566323(FLT3)
PSS: 102460565(FLT3)
CMY: 102932199(FLT3)
CPIC: 101945244(FLT3)
ACS: 100557093(flt3)
PVT: 110076475(FLT3)
PBI: 103049084(FLT3)
PMUR: 107287178(FLT3)
TSR: 106550427
PMUA: 114595759(FLT3)
GJA: 107105445(FLT3)
XTR: 101733150(flt3)
NPR: 108796338(FLT3)
DRE: 566708(flt3)
IPU: 108256707(flt3)
PHYP: 113541064(flt3)
AMEX: 103023809(flt3)
EEE: 113576161(flt3)
TRU: 101070905(flt3)
LCO: 104924953(flt3)
MZE: 101480071 101480562(flt3)
OLA: 101173420(flt3) 110013400
XMA: 102218761(flt3) 111606303
XCO: 114136905(flt3) 114136908
PRET: 103456624(flt3)
CVG: 107090784
NFU: 107382872(flt3)
KMR: 108230288(flt3)
ALIM: 106513431(flt3)
AOCE: 111584742(flt3)
CSEM: 103377257(flt3)
POV: 109641775 109642362(flt3)
LCF: 108881765(flt3)
SDU: 111220948(flt3)
SLAL: 111662946(flt3)
HCQ: 109514067(flt3)
BPEC: 110160944(flt3)
OTW: 112215396 112227703(flt3)
ELS: 105021947(flt3)
SFM: 108939670(flt3)
PKI: 111839117(flt3)
LCM: 102346199(FLT3)
CMK: 103183285(flt3)
RTP: 109913625(flt3)
EPA: 110241050
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7507245
  Authors
Small D, Levenstein M, Kim E, Carow C, Amin S, Rockwell P, Witte L, Burrow C, Ratajczak MZ, Gewirtz AM, et al.
  Title
STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells.
  Journal
Proc Natl Acad Sci U S A 91:459-63 (1994)
DOI:10.1073/pnas.91.2.459
  Sequence
[hsa:2322]
Reference
  Authors
Meshinchi S, Appelbaum FR
  Title
Structural and functional alterations of FLT3 in acute myeloid leukemia.
  Journal
Clin Cancer Res 15:4263-9 (2009)
DOI:10.1158/1078-0432.CCR-08-1123

KEGG   ORTHOLOGY: K05096Help
Entry
K05096                      KO                                     

Name
FLT1, VEGFR1
Definition
FMS-like tyrosine kinase 1 [EC:2.7.10.1]
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04066  HIF-1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko05202  Transcriptional misregulation in cancer
ko05323  Rheumatoid arthritis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
   04015 Rap1 signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
   04010 MAPK signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
   04066 HIF-1 signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
   04151 PI3K-Akt signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
  09163 Immune disease
   05323 Rheumatoid arthritis
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  VEGFR family [OT]
   K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
BRITE hierarchy
Genes
HSA: 2321(FLT1)
PTR: 452512(FLT1)
PPS: 100977352(FLT1)
GGO: 101133492(FLT1)
PON: 100456061(FLT1)
NLE: 100590200(FLT1)
MCC: 574133(FLT1)
MCF: 102115442(FLT1)
CSAB: 103249076(FLT1)
RRO: 104661639(FLT1)
RBB: 108512923(FLT1)
CJC: 100401993 100413680(FLT1)
SBQ: 101053773(FLT1)
MMU: 14254(Flt1)
MCAL: 110294038(Flt1)
MPAH: 110339167(Flt1)
RNO: 54251(Flt1)
CGE: 100761329(Flt1)
NGI: 103727233(Flt1)
HGL: 101711333(Flt1)
CCAN: 109694691(Flt1)
TUP: 102480253(FLT1)
CFA: 403727(FLT1)
VVP: 112918641(FLT1)
AML: 100483462(FLT1)
UMR: 103664410(FLT1)
UAH: 113251212(FLT1)
ORO: 101383542(FLT1)
ELK: 111158583
FCA: 101088292(FLT1)
PTG: 102955273(FLT1)
PPAD: 109266122(FLT1)
AJU: 106985536(FLT1)
BTA: 503620(FLT1)
BOM: 102269660(FLT1)
BIU: 109566823(FLT1)
BBUB: 102410059(FLT1)
CHX: 100860837(FLT1)
OAS: 443088(FLT1)
SSC: 396763(FLT1)
CFR: 102508666(FLT1)
CDK: 105086584(FLT1)
BACU: 103015874(FLT1)
LVE: 103079754(FLT1)
OOR: 101277470(FLT1)
DLE: 111175188(FLT1)
PCAD: 102986927(FLT1)
ECB: 100033957(FLT1)
EPZ: 103561902(FLT1)
EAI: 106832910(FLT1)
MNA: 107534361(FLT1)
HAI: 109390085 109395227(FLT1)
DRO: 112300051 112323117(FLT1)
PALE: 102891095(FLT1) 112469042
RAY: 107498919 107514322(FLT1)
MJV: 108385338
LAV: 100668928(FLT1)
TMU: 101352737
MDO: 100017469 100025304(FLT1)
SHR: 100921027 100930426(FLT1)
PCW: 110203184 110215551(FLT1)
OAA: 100090501(FLT1) 100090796
GGA: 374100(FLT1) 422316(VEGFRKDRL)
CJO: 107308289(FLT1) 107312792
NMEL: 110388861(FLT1) 110403438
APLA: 101795331(FLT1) 101797327
ACYG: 106038554 106041123(FLT1)
TGU: 100223459(FLT1) 100229347
LSR: 110467886 110476760(FLT1)
SCAN: 103816498 103827338(FLT1)
GFR: 102034196 102037593(FLT1)
FAB: 101806396(FLT1) 101808610
PHI: 102108061(FLT1) 102108458
PMAJ: 107202343(FLT1) 107203705
CCW: 104689893(FLT1) 104691716
ETL: 114062430 114067520(FLT1)
FPG: 101913316 101922526(FLT1)
FCH: 102051492 102058347(FLT1)
CLV: 102087545 102094103(FLT1)
EGZ: 104126066 104133690(FLT1)
NNI: 104021082 104023019(FLT1)
ACUN: 113479969 113485269(FLT1)
PADL: 103917156 103920091(FLT1)
AAM: 106489849 106500427(FLT1)
ASN: 102368462 102372479(FLT1)
AMJ: 102561001 102566553(FLT1)
PSS: 102446651 102456773(FLT1)
CMY: 102930345 102931972(FLT1)
PVT: 110074293 110076449(FLT1)
PBI: 103048455(FLT1) 103057723
PMUR: 107282917 107294150(FLT1)
TSR: 106546359(FLT1) 106550713
PMUA: 114588860 114595760(FLT1)
XLA: 108698372(kdrl.L) 108700541(kdrl.S) 373789(flt1.L) 379546(flt1.S)
XTR: 100492992(flt1) 100495109(kdrl)
NPR: 108791089 108796337(FLT1)
DRE: 544667(flt1) 796537(kdrl)
IPU: 108256487(flt1) 108269076
PHYP: 113528886 113541212(flt1)
AMEX: 103032355(flt1) 103038588
TRU: 101071220 101071361(flt1)
LCO: 104923474 104924951(flt1)
MZE: 101478748 101479515(flt1)
ONL: 100701270(flt1) 100707615
OLA: 100049480 101172940(flt1)
XMA: 102219213(flt1) 102221726
XCO: 114136904(flt1) 114139259
PRET: 103456619(flt1) 103471632
CVG: 107090808(flt1) 107092557
NFU: 107378530 107382874(flt1)
KMR: 108230231(flt1) 108231416
ALIM: 106513437(flt1) 106515430
LCF: 108872510 108881770(flt1)
SDU: 111221028(flt1) 111232404
SLAL: 111662923(flt1) 111666345
MALB: 109952200 109960158(flt1)
ELS: 105021948(flt1) 105029482
LCM: 102345121(FLT1) 102365485
CMK: 103178759 103183246(flt1)
CIN: 778954
SPU: 579837
SKO: 100313537(Vgfr) 102806353
DME: Dmel_CG8222(Pvr)
DER: 6543482
DSI: Dsimw501_GD22428(Dsim_GD22428)
DSR: 110176819
DPE: 6589575
DMN: 108163426
DWI: 6641517
DAZ: 108610455
DNV: 115563483
DHE: 111596228
MDE: 101895886
LCQ: 111685234
AAG: 5563777
AME: 413303
BIM: 100741439
BTER: 100646978
CCAL: 108628157
OBB: 114880994
SOC: 105207136
MPHA: 105828561
AEC: 105149416
ACEP: 105627372
VEM: 105563797
HST: 105190724
DQU: 106742591
CFO: 105257298
PGC: 109851977
OBO: 105280097
PCF: 106789615
NVI: 100116425
CSOL: 105364449
TCA: 662470
NVL: 108569966
BMOR: 101745869
BMAN: 114249695
PMAC: 106708843
PRAP: 110997017
HAW: 110383235
TNL: 113508407
API: 100159169
DNX: 107173314
AGS: 114131520
RMD: 113551843
BTAB: 109032088
CLEC: 106670705
CEL: CELE_F59F3.1(ver-3) CELE_T17A3.1(ver-1)
CBR: CBG17536
BMY: Bm1_37445
TSP: Tsp_00087
PCAN: 112559656
CRG: 105348465
MYI: 110447179
OBI: 106877728
LAK: 106159770
DGT: 114529432
HMG: 100209153
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Wiesmann C, Muller YA, de Vos AM.
  Title
Ligand-binding sites in Ig-like domains of receptor tyrosine kinases.
  Journal
J Mol Med 78:247-60 (2000)
DOI:10.1007/s001090000082
Reference
  Authors
Stuttfeld E, Ballmer-Hofer K
  Title
Structure and function of VEGF receptors.
  Journal
IUBMB Life 61:915-22 (2009)
DOI:10.1002/iub.234

KEGG   ORTHOLOGY: K05097Help
Entry
K05097                      KO                                     

Name
FLT4, VEGFR3
Definition
FMS-like tyrosine kinase 4 [EC:2.7.10.1]
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko05200  Pathways in cancer
ko05224  Breast cancer
Disease
H00535  Hereditary lymphedema
H01471  Lymphangioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4
   04015 Rap1 signaling pathway
    K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4
   04010 MAPK signaling pathway
    K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4
   04151 PI3K-Akt signaling pathway
    K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4
  09162 Cancer: specific types
   05224 Breast cancer
    K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  VEGFR family [OT]
   K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4
BRITE hierarchy
Genes
HSA: 2324(FLT4)
PTR: 462339(FLT4)
PPS: 100969442(FLT4)
GGO: 101130379(FLT4)
PON: 100462098(FLT4)
NLE: 100582920(FLT4)
MCC: 716412(FLT4)
MCF: 102123168(FLT4)
CSAB: 103245125(FLT4)
RRO: 104671523(FLT4)
RBB: 108514173(FLT4)
CJC: 100388404(FLT4)
SBQ: 101033672(FLT4)
MMU: 14257(Flt4)
MCAL: 110304471(Flt4)
MPAH: 110331550(Flt4)
RNO: 114110(Flt4)
MUN: 110547372(Flt4)
CGE: 100766609(Flt4)
NGI: 103749361(Flt4)
HGL: 101702013(Flt4)
CCAN: 109700252(Flt4)
OCU: 100008829(FLT4)
TUP: 102482918(FLT4)
CFA: 481464(FLT4)
VVP: 112911875(FLT4)
AML: 100478767(FLT4)
UMR: 103680018(FLT4)
UAH: 113261544(FLT4)
ORO: 101382368(FLT4)
ELK: 111158898
FCA: 101094727(FLT4)
PTG: 102960922(FLT4)
PPAD: 109278978(FLT4)
AJU: 106970218(FLT4)
BTA: 338031(FLT4)
BOM: 102267985(FLT4)
BIU: 109561327(FLT4)
BBUB: 102402057(FLT4)
CHX: 102180480(FLT4)
OAS: 101117247(FLT4)
SSC: 100518179(FLT4)
CFR: 102504702(FLT4)
CDK: 105100622(FLT4)
BACU: 103004554(FLT4)
LVE: 103074358(FLT4)
OOR: 101272910(FLT4)
DLE: 111170902(FLT4)
PCAD: 102988868(FLT4)
ECB: 100066773(FLT4)
EPZ: 103566205(FLT4)
EAI: 106843734(FLT4)
MYB: 102244912(FLT4)
MYD: 102756633(FLT4)
MNA: 107528437(FLT4)
HAI: 109392740(FLT4)
DRO: 112296393(FLT4)
PALE: 102889771(FLT4)
RAY: 107512332(FLT4)
MJV: 108408755(FLT4)
LAV: 100677038(FLT4)
TMU: 101340931
MDO: 100032078(FLT4)
SHR: 100932306(FLT4)
PCW: 110216702(FLT4)
OAA: 100087557(FLT4)
GGA: 395742(FLT4)
MGP: 100543111(FLT4)
CJO: 107320206(FLT4)
NMEL: 110405266(FLT4)
APLA: 101790164(FLT4)
ACYG: 106032675(FLT4)
TGU: 100218470(FLT4)
LSR: 110482723(FLT4)
SCAN: 103817296(FLT4)
GFR: 102039974(FLT4)
FAB: 101808166(FLT4)
PHI: 102110772(FLT4) 102112181
PMAJ: 107210757(FLT4)
CCAE: 111935550(FLT4)
CCW: 104689586(FLT4)
ETL: 114063191(FLT4)
FPG: 101918084(FLT4)
FCH: 102053583(FLT4)
CLV: 102090209(FLT4)
EGZ: 104123344(FLT4)
NNI: 104014191(FLT4)
ACUN: 113485325(FLT4)
PADL: 103915749(FLT4)
AAM: 106493463(FLT4)
ASN: 102373975(FLT4)
AMJ: 102567838(FLT4)
PSS: 102459372(FLT4)
CMY: 102944420
CPIC: 101942381(FLT4)
ACS: 100556373(flt4)
PVT: 110073488(FLT4)
TSR: 106538654(FLT4) 106554411
PMUA: 114591336(FLT4)
GJA: 107110308(FLT4)
XTR: 100493801(flt4)
NPR: 108785383(FLT4)
DRE: 30121(flt4)
IPU: 108268674(flt4)
PHYP: 113542868(flt4)
AMEX: 103037902
EEE: 113576525(flt4)
TRU: 101079004(flt4)
LCO: 104930066(flt4)
MZE: 101463681(flt4)
ONL: 100711033(flt4)
OLA: 100335137(flt4)
XMA: 102233039(flt4)
XCO: 114139113(flt4)
PRET: 103471109(flt4)
CVG: 107093459(flt4)
NFU: 107385122(flt4)
KMR: 108242065(flt4)
ALIM: 106515980(flt4)
AOCE: 111578770(flt4)
CSEM: 103391112(flt4)
POV: 109624596(flt4)
LCF: 108882862(flt4)
SDU: 111226519(flt4)
SLAL: 111652030(flt4)
HCQ: 109515935(flt4)
BPEC: 110163041(flt4)
MALB: 109968381
ELS: 105026780(flt4)
SFM: 108930359(flt4)
PKI: 111857710(flt4)
LCM: 102359993(FLT4)
CMK: 103188224(flt4)
RTP: 109927679(flt4)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1319394
  Authors
Galland F, Karamysheva A, Mattei MG, Rosnet O, Marchetto S, Birnbaum D
  Title
Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene.
  Journal
Genomics 13:475-8 (1992)
DOI:10.1016/0888-7543(92)90277-Y
  Sequence
[hsa:2324]

KEGG   ORTHOLOGY: K05098Help
Entry
K05098                      KO                                     

Name
KDR, VEGFR2, CD309
Definition
kinase insert domain protein receptor [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04370  VEGF signaling pathway
ko04510  Focal adhesion
ko05205  Proteoglycans in cancer
ko05418  Fluid shear stress and atherosclerosis
Disease
H01482  Infantile hemangioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
   04015 Rap1 signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
   04010 MAPK signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
   04370 VEGF signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
   04151 PI3K-Akt signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  VEGFR family [OT]
   K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
CD molecules [BR:ko04090]
 Proteins
  K05098  CD309, KDR; kinase insert domain receptor (a type III receptor tyrosine kinase)
BRITE hierarchy
Genes
HSA: 3791(KDR)
PTR: 461315(KDR)
PPS: 100986594(KDR)
GGO: 101127110(KDR)
PON: 100462446(KDR)
NLE: 100604569(KDR)
MCC: 698293(KDR)
MCF: 102136227(KDR)
CSAB: 103235670(KDR)
RRO: 104662002(KDR)
RBB: 108531591(KDR)
CJC: 100407045(KDR)
SBQ: 101036336(KDR)
MMU: 16542(Kdr)
MCAL: 110294607(Kdr)
MPAH: 110330463(Kdr)
RNO: 25589(Kdr)
MUN: 110556944(Kdr)
CGE: 100756294(Kdr)
NGI: 103734390(Kdr)
HGL: 101726029(Kdr)
CCAN: 109698964(Kdr)
OCU: 100008607(KDR)
TUP: 102489981(KDR)
CFA: 482154(KDR)
VVP: 112923722(KDR)
AML: 100484938(KDR)
UMR: 103672740(KDR)
UAH: 113262503(KDR)
ORO: 101371459(KDR)
ELK: 111149192
FCA: 101090260(KDR)
PTG: 102955197(KDR)
PPAD: 109278955(KDR)
AJU: 106983987(KDR)
BTA: 407170(KDR)
BOM: 102288007(KDR)
BIU: 109560478(KDR)
BBUB: 102412057(KDR)
CHX: 100860836(KDR)
OAS: 443087(KDR)
SSC: 397311(KDR)
CFR: 102520881(KDR)
CDK: 105091598(KDR)
BACU: 102999852(KDR)
LVE: 103087802(KDR)
OOR: 101290288(KDR)
DLE: 111169643(KDR)
PCAD: 102986785(KDR)
ECB: 100033959(KDR)
EPZ: 103554974(KDR)
EAI: 106836923(KDR)
MYB: 102256532(KDR)
MYD: 102760801(KDR)
MNA: 107532764(KDR)
HAI: 109381812(KDR)
DRO: 112316796(KDR)
PALE: 102896638(KDR)
RAY: 107520899(KDR)
MJV: 108400781(KDR)
LAV: 100656232(KDR)
TMU: 101348626
MDO: 100017311(KDR)
SHR: 100929091(KDR)
PCW: 110200147(KDR)
OAA: 100075389(KDR)
GGA: 395323(KDR)
MGP: 100542630
CJO: 107313758(KDR)
NMEL: 110398187(KDR)
APLA: 101797579(KDR)
ACYG: 106030825(KDR)
TGU: 100231879(KDR)
LSR: 110470474(KDR)
SCAN: 103825225(KDR)
GFR: 102042381(KDR)
FAB: 101821250(KDR)
PHI: 102113293(KDR)
PMAJ: 107202958(KDR)
CCAE: 111928018(KDR)
CCW: 104690864(KDR)
ETL: 114058319(KDR)
FPG: 101920584(KDR)
FCH: 102059103(KDR)
CLV: 102095316(KDR)
EGZ: 104129460(KDR)
NNI: 104020821(KDR)
ACUN: 113479117(KDR)
PADL: 103926348(KDR)
ASN: 102384502(KDR)
AMJ: 102567818(KDR)
PSS: 102451309(KDR)
CMY: 102936088(KDR)
CPIC: 101936813(KDR)
ACS: 100551738(kdr)
PVT: 110078415(KDR)
PBI: 103063796(KDR)
PMUR: 107295912(KDR)
TSR: 106552940(KDR)
PMUA: 114590419 114604144(KDR)
GJA: 107106034(KDR)
XLA: 108698463 108706593(kdr.S)
XTR: 100487501(kdr)
NPR: 108803904(KDR)
DRE: 554230(kdr)
IPU: 108258084(kdr)
PHYP: 113546829(kdr)
AMEX: 103022603(kdr)
EEE: 113586383(kdr)
TRU: 101073989(kdr)
LCO: 104919091(kdr)
NCC: 104947077(kdr)
MZE: 101472847(kdr)
ONL: 100692052(kdr)
OLA: 101162439(kdr)
XMA: 102225837(kdr)
XCO: 114151198(kdr)
PRET: 103463836(kdr)
CVG: 107091574(kdr)
NFU: 107393390(kdr)
KMR: 108243429(kdr)
ALIM: 106534849(kdr) 106537165
AOCE: 111569594(kdr)
CSEM: 103376704(kdr)
POV: 109625885(kdr)
LCF: 108879132(kdr) 108894371
SDU: 111226355(kdr)
SLAL: 111644356(kdr)
HCQ: 109532106(kdr)
BPEC: 110154739(kdr)
MALB: 109962035(kdr)
SASA: 106584120(kdr)
OTW: 112249135(kdr)
ELS: 105011839(kdr)
SFM: 108922800(kdr)
PKI: 111850117(kdr)
LCM: 102362684(KDR)
CMK: 103178168(kdr)
RTP: 109928943(kdr)
NVI: 100123205
SPIS: 111339267
HMG: 100214305
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1656371
  Authors
Terman BI, Carrion ME, Kovacs E, Rasmussen BA, Eddy RL, Shows TB
  Title
Identification of a new endothelial cell growth factor receptor tyrosine kinase.
  Journal
Oncogene 6:1677-83 (1991)
  Sequence
[hsa:3791]
Reference
  Authors
Stuttfeld E, Ballmer-Hofer K
  Title
Structure and function of VEGF receptors.
  Journal
IUBMB Life 61:915-22 (2009)
DOI:10.1002/iub.234

KEGG   ORTHOLOGY: K05099