Entry |
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Symbol |
BRAF
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Name |
B-Raf proto-oncogene serine/threonine-protein kinase [EC: 2.7.11.1]
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Pathway |
map01521 | EGFR tyrosine kinase inhibitor resistance |
map04270 | Vascular smooth muscle contraction |
map04650 | Natural killer cell mediated cytotoxicity |
map04810 | Regulation of actin cytoskeleton |
map04914 | Progesterone-mediated oocyte maturation |
map04928 | Parathyroid hormone synthesis, secretion and action |
map05022 | Pathways of neurodegeneration - multiple diseases |
map05208 | Chemical carcinogenesis - reactive oxygen species |
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Disease |
H00014 | Non-small cell lung cancer |
H00523 | Noonan syndrome and related disorders |
H01512 | Langerhans cell histiocytosis |
H01745 | Cardiofaciocutaneous syndrome |
H02425 | Erdheim-Chester disease |
|
Brite |
KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
04013 MAPK signaling pathway - fly
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
04012 ErbB signaling pathway
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
04015 Rap1 signaling pathway
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
04068 FoxO signaling pathway
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
04024 cAMP signaling pathway
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
04150 mTOR signaling pathway
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
09140 Cellular Processes
09143 Cell growth and death
04214 Apoptosis - fly
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
09144 Cellular community - eukaryotes
04510 Focal adhesion
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
09142 Cell motility
04810 Regulation of actin cytoskeleton
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
04062 Chemokine signaling pathway
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
09152 Endocrine system
04910 Insulin signaling pathway
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
04914 Progesterone-mediated oocyte maturation
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
04928 Parathyroid hormone synthesis, secretion and action
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
09153 Circulatory system
04270 Vascular smooth muscle contraction
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
09156 Nervous system
04726 Serotonergic synapse
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
04720 Long-term potentiation
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
04730 Long-term depression
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
04722 Neurotrophin signaling pathway
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
09158 Development and regeneration
04320 Dorso-ventral axis formation
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
05205 Proteoglycans in cancer
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
05208 Chemical carcinogenesis - reactive oxygen species
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
09162 Cancer: specific types
05210 Colorectal cancer
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
05212 Pancreatic cancer
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
05225 Hepatocellular carcinoma
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
05226 Gastric cancer
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
05214 Glioma
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
05216 Thyroid cancer
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
05221 Acute myeloid leukemia
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
05220 Chronic myeloid leukemia
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
05218 Melanoma
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
05211 Renal cell carcinoma
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
05219 Bladder cancer
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
05215 Prostate cancer
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
05213 Endometrial cancer
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
05224 Breast cancer
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
05223 Non-small cell lung cancer
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
09172 Infectious disease: viral
05161 Hepatitis B
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
05160 Hepatitis C
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
09164 Neurodegenerative disease
05010 Alzheimer disease
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
05022 Pathways of neurodegeneration - multiple diseases
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
09165 Substance dependence
05034 Alcoholism
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
09167 Endocrine and metabolic disease
04934 Cushing syndrome
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
01522 Endocrine resistance
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
Enzymes [BR:ko01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
Protein kinases [BR:ko01001]
Serine/threonine kinases: TKL group
RAF family [OT]
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
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Genes |
» show all
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Reference |
|
Authors |
Sithanandam G, Kolch W, Duh FM, Rapp UR |
Title |
Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies. |
Journal |
Oncogene 5:1775-80 (1990) |
Sequence |
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Reference |
|
Authors |
Brennan DF, Dar AC, Hertz NT, Chao WC, Burlingame AL, Shokat KM, Barford D |
Title |
A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK. |
Journal |
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Sequence |
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