KEGG   ORTHOLOGY: K04365
Entry
K04365                      KO                                     
Symbol
BRAF
Name
B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map01522  Endocrine resistance
map04010  MAPK signaling pathway
map04012  ErbB signaling pathway
map04013  MAPK signaling pathway - fly
map04015  Rap1 signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04068  FoxO signaling pathway
map04150  mTOR signaling pathway
map04214  Apoptosis - fly
map04270  Vascular smooth muscle contraction
map04320  Dorso-ventral axis formation
map04510  Focal adhesion
map04650  Natural killer cell mediated cytotoxicity
map04720  Long-term potentiation
map04722  Neurotrophin signaling pathway
map04726  Serotonergic synapse
map04730  Long-term depression
map04810  Regulation of actin cytoskeleton
map04910  Insulin signaling pathway
map04914  Progesterone-mediated oocyte maturation
map04928  Parathyroid hormone synthesis, secretion and action
map04934  Cushing syndrome
map05010  Alzheimer disease
map05022  Pathways of neurodegeneration - multiple diseases
map05034  Alcoholism
map05160  Hepatitis C
map05161  Hepatitis B
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05208  Chemical carcinogenesis - reactive oxygen species
map05210  Colorectal cancer
map05211  Renal cell carcinoma
map05212  Pancreatic cancer
map05213  Endometrial cancer
map05214  Glioma
map05215  Prostate cancer
map05216  Thyroid cancer
map05218  Melanoma
map05219  Bladder cancer
map05220  Chronic myeloid leukemia
map05221  Acute myeloid leukemia
map05223  Non-small cell lung cancer
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
Disease
H00014  Non-small cell lung cancer
H00020  Colorectal cancer
H00032  Thyroid cancer
H00038  Melanoma
H00523  Noonan syndrome and related disorders
H01512  Langerhans cell histiocytosis
H01738  Noonan syndrome
H01745  Cardiofaciocutaneous syndrome
H01984  Leopard syndrome
H02425  Erdheim-Chester disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04013 MAPK signaling pathway - fly
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04012 ErbB signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04015 Rap1 signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04068 FoxO signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04024 cAMP signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04150 mTOR signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
 09140 Cellular Processes
  09143 Cell growth and death
   04214 Apoptosis - fly
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04062 Chemokine signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04914 Progesterone-mediated oocyte maturation
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04928 Parathyroid hormone synthesis, secretion and action
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09156 Nervous system
   04726 Serotonergic synapse
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04720 Long-term potentiation
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04730 Long-term depression
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04722 Neurotrophin signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09158 Development and regeneration
   04320 Dorso-ventral axis formation
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05205 Proteoglycans in cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05208 Chemical carcinogenesis - reactive oxygen species
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05212 Pancreatic cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05225 Hepatocellular carcinoma
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05226 Gastric cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05214 Glioma
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05216 Thyroid cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05221 Acute myeloid leukemia
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05220 Chronic myeloid leukemia
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05218 Melanoma
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05211 Renal cell carcinoma
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05219 Bladder cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05215 Prostate cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05213 Endometrial cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05224 Breast cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05223 Non-small cell lung cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09172 Infectious disease: viral
   05161 Hepatitis B
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05160 Hepatitis C
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05022 Pathways of neurodegeneration - multiple diseases
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09165 Substance dependence
   05034 Alcoholism
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   01522 Endocrine resistance
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
Genes
HSA: 673(BRAF)
PTR: 463781(BRAF)
PPS: 100971666(BRAF)
GGO: 101145098(BRAF)
PON: 100442288(BRAF)
PPYG: 129041333(BRAF)
NLE: 100582848(BRAF)
HMH: 116814428(BRAF)
SSYN: 129485081(BRAF)
MCC: 693554(BRAF)
MCF: 101866436(BRAF)
MTHB: 126949633
MNI: 105471274(BRAF)
CSAB: 103227022(BRAF)
CATY: 105589671(BRAF)
PANU: 101022780(BRAF)
TGE: 112620354(BRAF)
MLEU: 105550515(BRAF)
RRO: 104659700(BRAF)
RBB: 108541537(BRAF)
TFN: 117072297(BRAF)
PTEH: 111521522(BRAF)
CANG: 105511179(BRAF)
CJC: 100403091(BRAF)
SBQ: 101052142(BRAF)
CIMI: 108283419(BRAF)
ANAN: 105713739(BRAF)
CSYR: 103271179(BRAF)
MMUR: 105873244(BRAF)
LCAT: 123647642(BRAF)
PCOQ: 105814677(BRAF)
OGA: 100955336(BRAF)
MMU: 109880(Braf)
MCAL: 110295945(Braf)
MPAH: 110316269(Braf)
RNO: 114486(Braf)
MCOC: 116098774(Braf)
ANU: 117721084(Braf)
MUN: 110545779(Braf)
CGE: 100771486(Braf)
MAUA: 101823512(Braf)
PROB: 127214235(Braf)
PLEU: 114706830(Braf)
MORG: 121435346 121463309
MFOT: 126505149
AAMP: 119806667(Braf)
NGI: 103726107(Braf)
HGL: 101702762(Braf)
CPOC: 100717765(Braf)
CCAN: 109682021 109698982
DORD: 105989470(Braf)
DSP: 122105936(Braf)
PLOP: 125347225(Braf)
NCAR: 124990234
MMMA: 107149118(Braf)
OCU: 100351964
OPI: 101526188(BRAF)
TUP: 102477389(BRAF)
GVR: 103596180(BRAF)
CFA: 475526(BRAF)
CLUD: 112650991(BRAF)
VVP: 112907060(BRAF)
VLG: 121489076(BRAF)
NPO: 129515848(BRAF)
AML: 100469346(BRAF)
UMR: 103669103(BRAF)
UAH: 113265167(BRAF)
UAR: 123788872(BRAF)
ELK: 111151941
LLV: 125080584
MPUF: 101671970(BRAF)
MNP: 132015636(BRAF)
MLK: 131829849(BRAF)
NVS: 122905138(BRAF)
ORO: 101377465(BRAF)
EJU: 114211580(BRAF)
ZCA: 113911009(BRAF)
MLX: 118021159(BRAF)
NSU: 110582758(BRAF)
LWW: 102748850(BRAF)
FCA: 101092346(BRAF)
PYU: 121028241(BRAF)
PCOO: 112866443(BRAF)
PBG: 122488405(BRAF)
PVIV: 125152888(BRAF)
LRUF: 124524722
PTG: 102951082(BRAF)
PPAD: 109269114(BRAF)
PUC: 125930477
AJU: 106970441
HHV: 120232948(BRAF)
BTA: 536051(BRAF)
BOM: 102278631(BRAF)
BIU: 109557698(BRAF)
BBUB: 102401079(BRAF)
BBIS: 104999381(BRAF)
CHX: 102174360(BRAF)
OAS: 101107438(BRAF)
BTAX: 128046969(BRAF)
ODA: 120877657(BRAF)
CCAD: 122438725(BRAF)
MBEZ: 129552712(BRAF)
SSC: 100514612(BRAF)
CFR: 102524100(BRAF)
CBAI: 105063019(BRAF)
CDK: 105091663(BRAF)
VPC: 102528789(BRAF)
BACU: 103002372(BRAF)
BMUS: 118900685(BRAF)
LVE: 103079256(BRAF)
OOR: 101277195(BRAF)
DLE: 111177653(BRAF)
PCAD: 102986916(BRAF)
PSIU: 116759212(BRAF)
NASI: 112398096(BRAF)
ECB: 100065760(BRAF)
EPZ: 103555338(BRAF)
EAI: 106842618(BRAF)
MYB: 102260644(BRAF)
MYD: 102760422(BRAF)
MMYO: 118666337(BRAF)
MLF: 102435241(BRAF)
MDT: 132242840(BRAF)
PKL: 118713842(BRAF)
EFUS: 103294085(BRAF)
MNA: 107531103(BRAF)
DRO: 112299790(BRAF)
SHON: 118989073(BRAF)
AJM: 119044502(BRAF)
PDIC: 114507230(BRAF)
PHAS: 123829653(BRAF)
MMF: 118619570(BRAF)
PPAM: 129062984(BRAF)
HAI: 109395605(BRAF)
RFQ: 117018062(BRAF)
PALE: 102878393(BRAF)
PGIG: 120601203(BRAF)
PVP: 105291659(BRAF)
RAY: 107504052(BRAF)
MJV: 108387830(BRAF) 108394305
TOD: 119247810(BRAF)
SARA: 101550676(BRAF)
SETR: 126010754(BRAF)
LAV: 100664119(BRAF)
TMU: 101353421
ETF: 101657046(BRAF)
DNM: 101411989(BRAF)
MDO: 100024057(BRAF)
GAS: 123249501(BRAF)
SHR: 100934801(BRAF)
AFZ: 127539354
PCW: 110216339(BRAF)
TVP: 118851882(BRAF)
OAA: 100086380(BRAF)
GGA: 396239(BRAF)
PCOC: 116226814(BRAF)
MGP: 100550268
CJO: 107315883(BRAF)
TPAI: 128073173(BRAF)
LMUT: 125697327(BRAF)
NMEL: 110394457(BRAF)
APLA: 101794380(BRAF)
ACYG: 106030997(BRAF)
CATA: 118259202(BRAF)
AFUL: 116492488(BRAF)
TGU: 100219601(BRAF)
LSR: 110482598(BRAF)
SCAN: 103819614(BRAF)
PMOA: 120501719(BRAF)
OTC: 121332742(BRAF)
PRUF: 121364303(BRAF)
GFR: 102032961(BRAF)
FAB: 101806469(BRAF)
OMA: 130263629(BRAF)
PHI: 102104959(BRAF)
PMAJ: 107204658(BRAF)
CCAE: 111936843(BRAF)
CCW: 104696191(BRAF)
CBRC: 103623333(BRAF)
ETL: 114056183(BRAF)
ZAB: 102072406(BRAF)
ZLE: 135461056(BRAF)
ACHL: 103807473(BRAF)
SVG: 106849383(BRAF)
MMEA: 130578420(BRAF)
HRT: 120751656(BRAF)
SATI: 136361658(BRAF)
FPG: 101919653(BRAF)
FCH: 102056938(BRAF)
CCRI: 104168469(BRAF)
NNT: 104405191(BRAF)
SHAB: 115605855(BRAF)
ACUN: 113475894(BRAF)
TALA: 104357409(BRAF)
ACHC: 115352782(BRAF)
HALD: 104325106(BRAF)
HLE: 104830972(BRAF)
AGEN: 126047628
GCL: 127014379
CSTI: 104561072(BRAF)
LDI: 104353259(BRAF)
MNB: 103769301(BRAF)
DPUB: 104302506(BRAF)
AVIT: 104273141(BRAF)
BRHI: 104500203(BRAF)
EGZ: 104135588(BRAF)
NNI: 104012385(BRAF)
PCRI: 104024649(BRAF)
PCAO: 104042672(BRAF)
PADL: 103924405(BRAF)
AFOR: 103906442(BRAF)
FGA: 104070516(BRAF)
GSTE: 104254888
CLV: 102088487(BRAF)
MUI: 104543796
PGUU: 104465903
PLET: 104625045(BRAF)
EHS: 104511841(BRAF)
CMAC: 104479333(BRAF)
CUCA: 104058945(BRAF)
TEO: 104379857(BRAF)
BREG: 104629609(BRAF)
OHA: 104328000(BRAF)
ACAR: 104529892(BRAF)
CPEA: 104396045(BRAF)
CVF: 104288573(BRAF)
RTD: 128904588(BRAF)
AAM: 106488842(BRAF)
AROW: 112974680(BRAF)
NPD: 112945628(BRAF)
TGT: 104571480(BRAF)
DNE: 112995022(BRAF)
SCAM: 104147394(BRAF)
ASN: 102380007(BRAF)
AMJ: 106737102(BRAF)
CPOO: 109316525(BRAF)
GGN: 109296160(BRAF)
PSS: 102448997(BRAF)
CMY: 102938595(BRAF)
CCAY: 125626994(BRAF)
DCC: 119849953(BRAF)
CPIC: 101945568(BRAF)
TST: 117881799(BRAF)
CABI: 116826446(BRAF)
MRV: 120369343(BRAF)
ACS: 100556317(braf)
ASAO: 132775824(BRAF)
PVT: 110082693(BRAF)
SUND: 121930700(BRAF)
PBI: 103054585(BRAF)
PMUR: 107288626(BRAF)
CTIG: 120316323(BRAF)
TSR: 106550529(BRAF)
PGUT: 117655368(BRAF)
APRI: 131202576(BRAF)
PTEX: 113451893(BRAF)
NSS: 113432841(BRAF)
VKO: 123028858(BRAF)
PMUA: 114604938(BRAF)
PRAF: 128422741(BRAF)
ZVI: 118090617(BRAF)
HCG: 128326894(BRAF)
GJA: 107108795(BRAF)
STOW: 125434335(BRAF)
EMC: 129336309(BRAF)
XLA: 398973(braf.S) 447268(braf.L)
XTR: 779570(braf)
NPR: 108793029(BRAF)
RTEM: 120932891(BRAF)
BBUF: 121005721(BRAF)
BGAR: 122921602(BRAF)
MUO: 115478758(BRAF)
GSH: 117366859(BRAF)
DRE: 403065(braf)
SRX: 107725591 107757253
SANH: 107655608 107694295(braf)
SGH: 107560707 107594271(braf)
CCAR: 109066802 109079739
CAUA: 113047804 113060924 113062903 113079077
CGIB: 127956143 127976136
PTET: 122342715(braf)
LROH: 127163979(braf)
OMC: 131539604(braf)
PPRM: 120476837(braf)
RKG: 130089912(braf)
MAMB: 125246121(braf)
CERY: 137024359(braf)
MASI: 127434962 127436383
TROS: 130547780(braf)
TDW: 130420618(braf)
MANU: 129431878(braf)
IPU: 108279928
IFU: 128623239(braf)
PHYP: 113532073(braf)
SMEO: 124401220(braf)
TFD: 113645735(braf)
TVC: 132858711(braf)
TRN: 134314976(braf)
AMEX: 103036930(braf)
CMAO: 118812517(braf)
EEE: 113572532(braf)
CHAR: 105912424(braf)
TRU: 653021(braf)
TFS: 130519257(braf)
TNG: GSTEN00013902G001
LCO: 104938610(braf)
NCC: 104967463(braf)
TBEN: 117483159(braf)
CGOB: 115028355(braf)
PGEO: 117468322(braf)
GACU: 117547129(braf)
EMAC: 134879164(braf)
ELY: 117249252(braf)
EFO: 125882719(braf)
PLEP: 121961201(braf)
SLUC: 116042103(braf)
ECRA: 117938524(braf)
ESP: 116673193(braf)
PFLV: 114550105(braf)
GAT: 120817257(braf)
PPUG: 119210797(braf)
AFB: 129112235(braf)
CLUM: 117725940(braf)
PSWI: 130200455(braf)
MSAM: 119882013 119917992(braf)
SCHU: 122871272(braf)
CUD: 121505311(braf)
ALAT: 119032901(braf)
MZE: 101476445(braf)
ONL: 100708231(braf)
OAU: 116309641(braf)
OLA: 101155814(braf)
OML: 112154271(braf)
CSAI: 133423809(braf)
XMA: 102231368(braf)
XCO: 114161014(braf)
XHE: 116736409(braf)
PRET: 103459555(braf)
PFOR: 103130320(braf)
PLAI: 106939408(braf)
PMEI: 106907580
GAF: 122826068(braf)
PPRL: 129354756(braf)
CVG: 107098826(braf)
CTUL: 119779101(braf)
GMU: 124883025(braf)
NFU: 107381355(braf)
KMR: 108241884(braf)
ALIM: 106527181(braf)
NWH: 119428176(braf)
AOCE: 111573494(braf)
MCEP: 125000036(braF)
CSEM: 103383021(braf)
POV: 109637498(braf)
SSEN: 122766159(braf)
HHIP: 117757425(braf)
HSP: 118101548(braf)
PPLT: 128428840(braf)
SMAU: 118286951(braf)
LCF: 108897545
SDU: 111224636(braf)
SLAL: 111664218(braf)
XGL: 120797472(braf)
HCQ: 109513640(braf)
SSCV: 125992421
SBIA: 133493252(braf)
PEE: 133396939(braf)
PTAO: 133472286(braf)
BPEC: 110162539(braf)
MALB: 109964703(braf)
BSPL: 114861505(braf)
SJO: 128353393(braf)
STRU: 115183182 115183708
OTW: 121843711
OMY: 110500907 118938871
OKI: 109886565 116366651
OKE: 127923762 127926940
SNH: 120050158(braf)
CCLU: 121556391 123480947
ELS: 105006078(braf)
SFM: 108936526(braf)
PKI: 111836730(braf)
AANG: 118219026(braf) 118232005
LOC: 102693824(braf)
PSPA: 121318501 121319596
ARUT: 117415020 117419793
PSEX: 120539426(braf)
LCM: 102365161(BRAF)
CMK: 103181856(braf)
RTP: 109917885(braf)
CPLA: 122559464(braf)
HOC: 132825020(braf)
LERI: 129706249(braf)
PMRN: 116947503 116951212 116952393 116952677
LRJ: 133351739 133355433 133356416 133356712 133356826
BFO: 118416519
BBEL: 109476887
CIN: 778741(raf1)
SCLV: 120328949
SPU: 575613
LPIC: 129257855
APLC: 110986911
ARUN: 117303355
AJC: 117125039
SKO: 100370381
DME: Dmel_CG2845(Raf)
DER: 6555595
DSE: 6616144
DSI: Dsimw501_GD16607(Dsim_phl)
DYA: Dyak_GE16257
DAN: 6504877
DSR: 110179440
DPO: 4815945
DPE: 6600090
DMN: 108155566
DWI: 6648391
DGR: 6564665
DMO: Dmoj_GI14690
DAZ: 108619185
DNV: 108656664
DHE: 111602415
DVI: 6633354
CCAT: 101451783
BOD: 106617209
BDR: 105230355
RZE: 108379720 108383072
AOQ: 129236885
TDA: 119667313 119667735 119669396 119669399
MDE: 101891362
SCAC: 106083012
LCQ: 111691044
LSQ: 119602204
GFS: 119643132
ECOE: 129939619
CLON: 129608221
HIS: 119656159
AGA: 1278538
ACOZ: 120950415
AARA: 120895416
AMER: 121593605
ASTE: 118512429
AFUN: 125770083
AMOU: 128303154
AALI: 118467124
AAG: 5579530
AALB: 109418642
ASUA: 134224489
CQU: CpipJ_CPIJ004499
CPII: 120428354
CNS: 116342361
BCOO: 119076032
AME: 413448
ACER: 107997133
ALAB: 122716406
ADR: 102679576
AFLR: 100871206
BIM: 100741263
BBIF: 117205908
BVK: 117243363
BVAN: 117153956
BTER: 100645437
BAFF: 126916201
BPYO: 122565866
BPAS: 132905244
FVI: 122535591
CCAL: 108628617
OBB: 114877595
OLG: 117610763
MGEN: 117221232
NMEA: 116434829
CGIG: 122398319
SOC: 105202082
MPHA: 105840022
AEC: 105146178
ACEP: 105623044
PBAR: 105434155 105434156
VEM: 105562489
HST: 105192683
DQU: 106748587
CFO: 105253402
FEX: 115243616
LHU: 105678021(Raf)
PGC: 109860595
OBO: 105277811
PCF: 106786260
PFUC: 122525366
VPS: 122633361
VCRB: 124429335
NVI: 100121496
CSOL: 105368960
TPRE: 106655603
LHT: 122506957
LBD: 127276695
MDL: 103572940
CGLO: 123271344
FAS: 105267313
DAM: 107038977
AGIF: 122860205
CINS: 118074763
VCAN: 122411710
CCIN: 107270964
DSM: 124407368
NPT: 124214923
NFB: 124178155
NLO: 107218042
NVG: 124300879
AROA: 105684796
TCA: 655334(raf)
DPA: 109543674
SOY: 115887686
AGRG: 126742783
ATD: 109597407 109597414
AGB: 108914944
LDC: 111502655
DVV: 114329356
NVL: 108559414
APLN: 108739255
PPYR: 116163476 116170104
OTU: 111419583
BMOR: 100529216(raf)
BMAN: 114242624
MSEX: 115448399
DPL: KGM_215325
BANY: 112046713
MJU: 123864347
NIQ: 126778001
VCD: 124538066
MCIX: 123666532
PMAC: 106708128
PPOT: 106108126
PXU: 106117416
PRAP: 110991813
PBX: 123712950
PNAP: 125063707
ZCE: 119830135
CCRC: 123703665
LSIN: 126964496
AAGE: 121729249
HAW: 110374645
HZE: 124635954
TNL: 113493668
SLIU: 111357471
ATRA: 106132949
GMW: 113522874
PXY: 105383656
PGW: 126382209
CFEL: 113372268
CCRN: 123291750
API: 100169206
DNX: 107170145
AGS: 114130019
RMD: 113549510
ACOO: 126844697
DVT: 126893755
BTAB: 109030122
CLEC: 106668148
HHAL: 106691840(Raf)
NLU: 111060035 120352284
HVI: 124360277
MQU: 128992034
PHU: Phum_PHUM472510
FOC: 113209324
TPAL: 117641560
ZNE: 110836363
CSEC: 111872156
SGRE: 126281601
BROR: 134542488
IEL: 124171889
FCD: 110858255
DPX: DAPPUDRAFT_315683
DMK: 116928830
DPZ: 124310935
PVM: 113806524 113814953
PJA: 122261263
PCHN: 125032094
PMOO: 119597121
HAME: 121874911
PCLA: 123762745
CQD: 128701353
PTRU: 123502019
ESN: 127000841
MNZ: 135209911
HAZT: 108679261
EAF: 111708752
LSM: 121114024
TCF: 131893266
PPOI: 119111312
ISC: 8037688
DSV: 119462579
RSAN: 119395704
RMP: 119174096
VDE: 111246332
VJA: 111272517
TUT: 107365833
DPTE: 113794008 113796753 113799754
DFR: 124495554 124498924
CSCU: 111640304
CVS: 136977524
PTEP: 107445892
ABRU: 129975236
UDV: 129227853 129228047
SDM: 118184718
LPOL: 106462215 106467039 106471907
PMEO: 129590857
CEL: CELE_Y73B6A.5(lin-45)
CBR: CBG_05382(Cbr-lin-45)
CRQ: GCK72_013744
NAI: NECAME_16277
BMY: BM_BM7093(Bma-lin-45)
LOA: LOAG_17342
TSP: Tsp_05804
HRO: HELRODRAFT_86641
LGI: LOTGIDRAFT_116428
PVUL: 126827066
PCAN: 112564136
BGT: 106052145
GAE: 121367399
HRF: 124145871
HRJ: 124270168
CRG: 105321795
CANU: 128159074
CVN: 111108145 111108199
OED: 125654224
MYI: 110443412
PMAX: 117331394
MCAF: 127723397
MMER: 123529845
RPHI: 132742381
DPOL: 127832079
MAEA: 128216809
OBI: 106874195
OSN: 115209716
LAK: 106171322
SMM: Smp_176990
OVI: T265_04189
EGL: EGR_04277
LLON: 135490638
NVE: 5519181
EPA: 110238451
ATEN: 116305159
ADF: 107343857
AMIL: 114976018
PDAM: 113668705
SPIS: 111334882
DGT: 114538412
XEN: 124447438
HMG: 100201878
HSY: 130654992
RES: 135686246
AQU: 100640705
 » show all
Reference
PMID:2284096
  Authors
Sithanandam G, Kolch W, Duh FM, Rapp UR
  Title
Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies.
  Journal
Oncogene 5:1775-80 (1990)
  Sequence
[hsa:673]
Reference
PMID:21441910
  Authors
Brennan DF, Dar AC, Hertz NT, Chao WC, Burlingame AL, Shokat KM, Barford D
  Title
A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK.
  Journal
Nature 472:366-9 (2011)
DOI:10.1038/nature09860
  Sequence
[hsa:673]

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (94)   
   KEGG PATHWAY (94)   
Disease (10)   
   KEGG DISEASE (10)   
Drug (13)   
   KEGG DRUG (13)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1989)   
   KEGG GENES (695)   
   KEGG MGENES (194)   
   RefGene (1085)   
   OC (15)   
Literature (2)   
   PubMed (2)   
All databases (2112)   

Download RDF
KEGG   ORTHOLOGY: K04366
Entry
K04366                      KO                                     
Symbol
RAF1
Name
RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map01522  Endocrine resistance
map04010  MAPK signaling pathway
map04012  ErbB signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04068  FoxO signaling pathway
map04071  Sphingolipid signaling pathway
map04072  Phospholipase D signaling pathway
map04140  Autophagy - animal
map04150  mTOR signaling pathway
map04151  PI3K-Akt signaling pathway
map04210  Apoptosis
map04218  Cellular senescence
map04270  Vascular smooth muscle contraction
map04360  Axon guidance
map04370  VEGF signaling pathway
map04371  Apelin signaling pathway
map04510  Focal adhesion
map04540  Gap junction
map04550  Signaling pathways regulating pluripotency of stem cells
map04613  Neutrophil extracellular trap formation
map04625  C-type lectin receptor signaling pathway
map04630  JAK-STAT signaling pathway
map04650  Natural killer cell mediated cytotoxicity
map04660  T cell receptor signaling pathway
map04662  B cell receptor signaling pathway
map04664  Fc epsilon RI signaling pathway
map04666  Fc gamma R-mediated phagocytosis
map04720  Long-term potentiation
map04722  Neurotrophin signaling pathway
map04726  Serotonergic synapse
map04730  Long-term depression
map04810  Regulation of actin cytoskeleton
map04910  Insulin signaling pathway
map04912  GnRH signaling pathway
map04914  Progesterone-mediated oocyte maturation
map04915  Estrogen signaling pathway
map04916  Melanogenesis
map04917  Prolactin signaling pathway
map04919  Thyroid hormone signaling pathway
map04921  Oxytocin signaling pathway
map04926  Relaxin signaling pathway
map04928  Parathyroid hormone synthesis, secretion and action
map04929  GnRH secretion
map04935  Growth hormone synthesis, secretion and action
map05010  Alzheimer disease
map05022  Pathways of neurodegeneration - multiple diseases
map05034  Alcoholism
map05132  Salmonella infection
map05152  Tuberculosis
map05160  Hepatitis C
map05161  Hepatitis B
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05165  Human papillomavirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05170  Human immunodeficiency virus 1 infection
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05206  MicroRNAs in cancer
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
map05210  Colorectal cancer
map05211  Renal cell carcinoma
map05212  Pancreatic cancer
map05213  Endometrial cancer
map05214  Glioma
map05215  Prostate cancer
map05218  Melanoma
map05219  Bladder cancer
map05220  Chronic myeloid leukemia
map05221  Acute myeloid leukemia
map05223  Non-small cell lung cancer
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05230  Central carbon metabolism in cancer
map05231  Choline metabolism in cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Disease
H00294  Dilated cardiomyopathy
H00523  Noonan syndrome and related disorders
H01738  Noonan syndrome
H01984  Leopard syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04012 ErbB signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04014 Ras signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04015 Rap1 signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04370 VEGF signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04371 Apelin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04630 JAK-STAT signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04068 FoxO signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04072 Phospholipase D signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04071 Sphingolipid signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04024 cAMP signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04022 cGMP-PKG signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04151 PI3K-Akt signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04150 mTOR signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09143 Cell growth and death
   04210 Apoptosis
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04218 Cellular senescence
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04540 Gap junction
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04550 Signaling pathways regulating pluripotency of stem cells
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04625 C-type lectin receptor signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04650 Natural killer cell mediated cytotoxicity
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04660 T cell receptor signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04662 B cell receptor signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04664 Fc epsilon RI signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04666 Fc gamma R-mediated phagocytosis
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04062 Chemokine signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04929 GnRH secretion
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04912 GnRH signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04915 Estrogen signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04914 Progesterone-mediated oocyte maturation
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04917 Prolactin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04921 Oxytocin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04926 Relaxin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04935 Growth hormone synthesis, secretion and action
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04919 Thyroid hormone signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04928 Parathyroid hormone synthesis, secretion and action
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04916 Melanogenesis
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09156 Nervous system
   04726 Serotonergic synapse
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04720 Long-term potentiation
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04730 Long-term depression
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04722 Neurotrophin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09158 Development and regeneration
   04360 Axon guidance
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05206 MicroRNAs in cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05205 Proteoglycans in cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05207 Chemical carcinogenesis - receptor activation
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05208 Chemical carcinogenesis - reactive oxygen species
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05230 Central carbon metabolism in cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05231 Choline metabolism in cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05212 Pancreatic cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05225 Hepatocellular carcinoma
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05226 Gastric cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05214 Glioma
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05221 Acute myeloid leukemia
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05220 Chronic myeloid leukemia
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05218 Melanoma
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05211 Renal cell carcinoma
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05219 Bladder cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05215 Prostate cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05213 Endometrial cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05224 Breast cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05223 Non-small cell lung cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05161 Hepatitis B
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05160 Hepatitis C
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05164 Influenza A
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05163 Human cytomegalovirus infection
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05165 Human papillomavirus infection
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05152 Tuberculosis
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05022 Pathways of neurodegeneration - multiple diseases
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09165 Substance dependence
   05034 Alcoholism
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   01522 Endocrine resistance
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
Genes
HSA: 5894(RAF1)
PTR: 460182(RAF1)
PPS: 100972902(RAF1)
GGO: 101136454(RAF1)
PON: 100173732(RAF1)
PPYG: 129032695(RAF1)
NLE: 100582599(RAF1)
HMH: 116466754(RAF1)
SSYN: 129471104(RAF1)
MCC: 694725(RAF1)
MCF: 102125312(RAF1)
MTHB: 126949054
MNI: 105477727(RAF1)
CSAB: 103228031(RAF1)
CATY: 105585803(RAF1)
PANU: 101009029(RAF1)
TGE: 112619721(RAF1)
MLEU: 105542175(RAF1)
RRO: 104673299(RAF1)
RBB: 108517986(RAF1)
TFN: 117083269(RAF1) 117084479
PTEH: 111546904(RAF1)
CANG: 105519101(RAF1)
CJC: 100415300(RAF1)
SBQ: 101054052(RAF1)
CIMI: 108284634(RAF1)
ANAN: 105730825(RAF1)
CSYR: 103263745(RAF1)
MMUR: 105882676(RAF1)
LCAT: 123638125(RAF1)
PCOQ: 105819002(RAF1)
OGA: 100941062(RAF1)
MMU: 110157(Raf1)
MCAL: 110296919(Raf1)
MPAH: 110314893(Raf1)
RNO: 24703(Raf1)
MCOC: 116099433(Raf1)
ANU: 117715476(Raf1)
MUN: 110550814(Raf1)
CGE: 100769018(Raf1)
MAUA: 101843997(Raf1)
PROB: 127236205(Raf1)
PLEU: 114689636(Raf1)
MORG: 121443425(Raf1)
MFOT: 126505550
AAMP: 119805902 119808272(Raf1)
NGI: 103751450(Raf1)
HGL: 101721841(Raf1)
CPOC: 100720110(Raf1)
CCAN: 109694940(Raf1)
DORD: 105981244(Raf1)
DSP: 122107826(Raf1)
PLOP: 125358819(Raf1)
NCAR: 124971006
MMMA: 107150090(Raf1)
OCU: 100347407
OPI: 101534290(RAF1)
TUP: 102497488(RAF1)
GVR: 103590618(RAF1)
CFA: 484648(RAF1)
CLUD: 112661394(RAF1)
VVP: 112933694(RAF1)
VLG: 121494281(RAF1)
NPO: 129522592(RAF1)
AML: 100482255(RAF1)
UMR: 103669540(RAF1)
UAH: 113257190(RAF1)
UAR: 123802053(RAF1)
ELK: 111144322
LLV: 125108469
MPUF: 101690482(RAF1)
MNP: 132011570(RAF1)
MLK: 131824239(RAF1)
NVS: 122909192(RAF1)
ORO: 101372149(RAF1)
EJU: 114207692(RAF1)
ZCA: 113916244(RAF1)
MLX: 118005431(RAF1)
NSU: 110584928(RAF1)
LWW: 102726914(RAF1)
FCA: 101096047(RAF1)
PYU: 121041241(RAF1)
PCOO: 112859466(RAF1)
PBG: 122487521(RAF1)
PVIV: 125152491(RAF1)
LRUF: 124523760
PTG: 102955852(RAF1)
PPAD: 109257492(RAF1)
PUC: 125930728
AJU: 106977129
HHV: 120231327(RAF1)
BTA: 521196(RAF1)
BOM: 102288216(RAF1)
BIU: 109576053(RAF1)
BBUB: 102412922(RAF1)
BBIS: 105004742(RAF1)
CHX: 108638619(RAF1)
OAS: 101103190(RAF1)
BTAX: 128043403(RAF1)
ODA: 120868108(RAF1)
CCAD: 122425059(RAF1)
MBEZ: 129547721(RAF1)
SSC: 100737448(RAF1)
CFR: 102517521(RAF1)
CBAI: 105067475(RAF1)
CDK: 105093099(RAF1)
VPC: 102543308(RAF1)
BACU: 103014337(RAF1)
BMUS: 118904127(RAF1)
LVE: 103087933(RAF1)
OOR: 101272984(RAF1)
DLE: 111168973(RAF1)
PCAD: 102987866(RAF1)
PSIU: 116761625(RAF1)
NASI: 112407243(RAF1)
ECB: 100051110(RAF1)
EPZ: 103554541(RAF1)
EAI: 106829345(RAF1) 106830991
MYB: 102254003(RAF1)
MYD: 102772748(RAF1)
MMYO: 118668076(RAF1)
MLF: 102434453(RAF1)
MDT: 132215436(RAF1)
PKL: 118715231(RAF1) 118731837
EFUS: 103295757(RAF1)
MNA: 107534729(RAF1)
DRO: 112301126(RAF1)
SHON: 118990300(RAF1)
AJM: 119044815(RAF1)
PDIC: 114501905(RAF1)
PHAS: 123814364(RAF1)
MMF: 118633343(RAF1)
PPAM: 129088423(RAF1)
HAI: 109384548(RAF1)
RFQ: 117037259(RAF1)
PALE: 102893439(RAF1)
PGIG: 120621476(RAF1)
PVP: 105299021(RAF1)
RAY: 107519729(RAF1)
MJV: 108394341(RAF1)
TOD: 119255730(RAF1)
SARA: 101545329(RAF1)
SETR: 125998044(RAF1)
LAV: 100655727(RAF1)
TMU: 101357840
ETF: 101656360(RAF1)
DNM: 101421211(RAF1)
MDO: 100015410(RAF1)
GAS: 123239466(RAF1)
SHR: 100935202(RAF1)
AFZ: 127552087
PCW: 110204892(RAF1)
TVP: 118831413(RAF1)
OAA: 100089456(RAF1)
GGA: 396245(RAF1)
PCOC: 116238931(RAF1)
MGP: 100541264(RAF1)
CJO: 107319673(RAF1)
TPAI: 128078363(RAF1)
LMUT: 125698855(RAF1)
NMEL: 110404723(RAF1)
APLA: 101795633(RAF1)
ACYG: 106040056(RAF1)
CATA: 118253692(RAF1)
AFUL: 116493064(RAF1)
TGU: 100218264(RAF1)
LSR: 110470647(RAF1)
SCAN: 103816934(RAF1)
PMOA: 120501778(RAF1)
OTC: 121348231(RAF1)
PRUF: 121349059(RAF1)
GFR: 102034977(RAF1)
FAB: 101816261(RAF1)
OMA: 130258126(RAF1)
PHI: 102103825(RAF1)
PMAJ: 107210130(RAF1)
CCAE: 111935240(RAF1)
CCW: 104695743(RAF1)
CBRC: 103617696(RAF1)
ETL: 114059216(RAF1)
ZAB: 102068297(RAF1)
ZLE: 135453339(RAF1)
ACHL: 103811193(RAF1)
SVG: 106849281(RAF1)
MMEA: 130582944(RAF1)
HRT: 120758250(RAF1)
SATI: 136366092(RAF1)
FPG: 101911761(RAF1)
FCH: 102051503(RAF1)
CCRI: 104158886(RAF1)
NNT: 104411647(RAF1)
SHAB: 115614046(RAF1)
ACUN: 113484728(RAF1)
TALA: 104365731(RAF1)
ACHC: 115353699(RAF1)
HALD: 104321152(RAF1)
HLE: 104842226(RAF1)
AGEN: 126049891
GCL: 127021590
CSTI: 104559299(RAF1)
LDI: 104354943(RAF1)
MNB: 103770485(RAF1)
DPUB: 104301896(RAF1)
AVIT: 104274018(RAF1)
BRHI: 104494904(RAF1)
EGZ: 104124306(RAF1)
NNI: 104022929(RAF1)
PCRI: 104038505(RAF1)
PCAO: 104051126(RAF1)
PADL: 103915210(RAF1)
AFOR: 103905412(RAF1)
FGA: 104082216(RAF1)
GSTE: 104251683
CLV: 102096788(RAF1)
MUI: 104541372(RAF1)
PLET: 104627321(RAF1)
EHS: 104503923
CMAC: 104477214(RAF1)
CUCA: 104064618(RAF1)
TEO: 104377130(RAF1)
BREG: 104632729
OHA: 104335221(RAF1)
ACAR: 104527077(RAF1)
CPEA: 104398706(RAF1)
CVF: 104290771(RAF1)
RTD: 128915881(RAF1)
AAM: 106488826(RAF1)
AROW: 112966394(RAF1)
NPD: 112953017(RAF1)
TGT: 104565167(RAF1)
DNE: 112982840(RAF1)
SCAM: 104152703(RAF1)
ASN: 102374398(RAF1)
AMJ: 102576986(RAF1)
CPOO: 109311365(RAF1)
GGN: 109289142(RAF1)
PSS: 102458748(RAF1)
CMY: 102929883(RAF1)
CCAY: 125640538(RAF1)
DCC: 119858193(RAF1)
CPIC: 101933019(RAF1)
TST: 117879804(RAF1)
CABI: 116820235(RAF1)
MRV: 120409502(RAF1)
ACS: 100557613(raf1)
ASAO: 132769229(RAF1)
PVT: 110083799(RAF1)
SUND: 121921146(RAF1)
PBI: 103054563(RAF1)
PMUR: 107295520
CTIG: 120307629(RAF1)
TSR: 106541257 106542299(RAF1)
PGUT: 117677681(RAF1)
APRI: 131192562(RAF1)
PTEX: 113452732(RAF1)
NSS: 113418209(RAF1)
VKO: 123034069(RAF1)
PMUA: 114591641(RAF1)
PRAF: 128408254(RAF1)
ZVI: 118080671(RAF1)
HCG: 128346700(RAF1)
GJA: 107118023(RAF1)
STOW: 125429531(RAF1)
EMC: 129328096(RAF1)
XLA: 108704012(raf1.L) 397857(raf1.S)
XTR: 549871(raf1)
NPR: 108787573
RTEM: 120945285(RAF1)
BBUF: 120978563(RAF1)
BGAR: 122943150(RAF1)
MUO: 115471604(RAF1)
GSH: 117351133(RAF1)
DRE: 30716(raf1a) 557109(raf1b)
SRX: 107713759 107742031 107758125(raf1)
SANH: 107675968 107684881 107687309(raf1)
SGH: 107555780 107564278(raf1) 107571214
CCAR: 109081018(raf1) 109086906 109099958
CAUA: 113054940(raf1) 113068641
CGIB: 127944696 128022684
PTET: 122328991(raf1a) 122354079(raf1b)
LROH: 127154571(raf1a) 127172884(raf1b)
OMC: 131531944(raf1a) 131549244(raf1b)
PPRM: 120460946(raf1b) 120479037(raf1a)
RKG: 130094731(raf1a) 130100901(raf1b)
MAMB: 125256524(raf1b) 125259699(raf1a)
CIDE: 127504685 127522563
CERY: 137009724(raf1a) 137021787(raf1b)
MASI: 127419567 127419674 127425942
TROS: 130570996(raf1b)
TDW: 130409011(raf1a) 130410117(raf1b)
MANU: 129427335(raf1b) 129431253(raf1a)
IPU: 108255012(raf1b) 108276324(raf1a)
IFU: 128619536(raf1a) 128624988(raf1b)
PHYP: 113537867(raf1) 113545603
SMEO: 124399172(raf1a) 124402387(raf1b)
TFD: 113639099(raf1b) 113650909(raf1a)
TVC: 132838004(raf1b) 132862286(raf1a)
TRN: 134302059(raf1b) 134333975(raf1a)
AMEX: 103025658(raf1a) 103027930(raf1b)
CMAO: 118799451(raf1b) 118822149(raf1a)
EEE: 113572287 113580611
CHAR: 105900156(raf1a) 105904961(raf1b)
TRU: 654310(raf1)
TFS: 130529511(raf1a)
TNG: GSTEN00023725G001
LCO: 104940217(raf1)
NCC: 104958741(raf1)
TBEN: 117479493(raf1a)
CGOB: 115010471
PGEO: 117449273(raf1a)
GACU: 117542983(raf1a)
EMAC: 134865609(raf1a)
ELY: 117258233(raf1a)
EFO: 125891335(raf1a)
PLEP: 121946649(raf1a)
SLUC: 116062082(raf1a)
ECRA: 117947286(raf1a)
ESP: 116693071(raf1)
PFLV: 114559447(raf1)
GAT: 120829430(raf1a)
PPUG: 119221983(raf1a)
AFB: 129099416(raf1a)
CLUM: 117733950(raf1a)
PSWI: 130199044(raf1a)
MSAM: 119905315(raf1a)
SCHU: 122883572(raf1a)
CUD: 121517411(raf1a)
ALAT: 119022303(raf1a)
MZE: 101470685(raf1)
ONL: 100709219(raf1)
OAU: 116331070(raf1a)
OLA: 101173784(raf1)
OML: 112159520(raf1a)
CSAI: 133457013(raf1a)
XMA: 102234445(raf1)
XCO: 114140577(raf1)
XHE: 116719889(raf1)
PRET: 103467582(raf1)
PFOR: 103145099(raf1)
PLAI: 106948092(raf1)
PMEI: 106904980(raf1)
GAF: 122832939(raf1a)
PPRL: 129370284(raf1a)
CVG: 107088168(raf1)
CTUL: 119781396(raf1a)
GMU: 124866030(raf1a)
NFU: 107391092(raf1)
KMR: 108232050(raf1a)
ALIM: 106519055(raf1)
NWH: 119417510(raf1a)
AOCE: 111588716(raf1)
MCEP: 124999107(raf1a)
CSEM: 103385533(raf1)
POV: 109635227(raf1)
SSEN: 122776778(raf1a)
HHIP: 117765330(raf1a)
HSP: 118111456(raf1a)
PPLT: 128441791(raf1a)
SMAU: 118316902(raf1a)
LCF: 108900163(raf1a)
SDU: 111217320(raf1)
SLAL: 111672203(raf1)
XGL: 120803375(raf1a)
HCQ: 109507267(raf1)
SSCV: 125987804
SBIA: 133512699(raf1a)
PEE: 133409227(raf1a)
PTAO: 133487624(raf1a)
BPEC: 110164922(raf1)
MALB: 109966113(raf1)
BSPL: 114858281(raf1a)
SJO: 128357963(raf1a)
SASA: 100136351(raf1) 106566757(RAF1a) 106571905(RAF1b)
STRU: 115149903(raf1) 115166136 115168396
OTW: 112215764(raf1a) 112222214
OMY: 110492413 110531995(raf1a)
OGO: 124031697(raf1a) 124045679
ONE: 115131882
OKI: 109869276 109907765
OKE: 118359627 118361399(raf1a)
SALP: 111966206 111976869
SNH: 120059498(raf1a) 120061320
CCLU: 121538562 121545408
ELS: 105013076(raf1) 105029139
SFM: 108925552 108929807(raf1)
PKI: 111837477(raf1) 111840300
AANG: 118210668(raf1b)
LOC: 102692545(raf1)
PSPA: 121297980 121328554
ARUT: 117412241 117414023
PSEX: 120540276(raf1b)
LCM: 102357545(RAF1)
CMK: 103185022(raf1b)
RTP: 109911534(raf1b)
CPLA: 122558962(raf1b)
HOC: 132822314(raf1b)
LERI: 129704842(raf1b)
SLA: SERLADRAFT_448085
 » show all
Reference
PMID:3003687
  Authors
Bonner TI, Oppermann H, Seeburg P, Kerby SB, Gunnell MA, Young AC, Rapp UR
  Title
The complete coding sequence of the human raf oncogene and the corresponding structure of the c-raf-1 gene.
  Journal
Nucleic Acids Res 14:1009-15 (1986)
DOI:10.1093/nar/14.2.1009
  Sequence
[hsa:5894]
Reference
PMID:11427728
  Authors
Chen J, Fujii K, Zhang L, Roberts T, Fu H
  Title
Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism.
  Journal
Proc Natl Acad Sci U S A 98:7783-8 (2001)
DOI:10.1073/pnas.141224398

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Pathway (166)   
   KEGG PATHWAY (166)   
Disease (4)   
   KEGG DISEASE (4)   
Drug (8)   
   KEGG DRUG (8)   
Chemical reaction (1)   
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Download RDF
KEGG   ORTHOLOGY: K08845
Entry
K08845                      KO                                     
Symbol
ARAF, ARAF1
Name
A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map01522  Endocrine resistance
map04010  MAPK signaling pathway
map04012  ErbB signaling pathway
map04068  FoxO signaling pathway
map04270  Vascular smooth muscle contraction
map04650  Natural killer cell mediated cytotoxicity
map04720  Long-term potentiation
map04726  Serotonergic synapse
map04730  Long-term depression
map04810  Regulation of actin cytoskeleton
map04910  Insulin signaling pathway
map04914  Progesterone-mediated oocyte maturation
map04928  Parathyroid hormone synthesis, secretion and action
map05010  Alzheimer disease
map05022  Pathways of neurodegeneration - multiple diseases
map05034  Alcoholism
map05160  Hepatitis C
map05161  Hepatitis B
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05208  Chemical carcinogenesis - reactive oxygen species
map05210  Colorectal cancer
map05211  Renal cell carcinoma
map05212  Pancreatic cancer
map05213  Endometrial cancer
map05214  Glioma
map05215  Prostate cancer
map05218  Melanoma
map05219  Bladder cancer
map05220  Chronic myeloid leukemia
map05221  Acute myeloid leukemia
map05223  Non-small cell lung cancer
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
Disease
H02425  Erdheim-Chester disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04012 ErbB signaling pathway
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04068 FoxO signaling pathway
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  09152 Endocrine system
   04910 Insulin signaling pathway
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04914 Progesterone-mediated oocyte maturation
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04928 Parathyroid hormone synthesis, secretion and action
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  09156 Nervous system
   04726 Serotonergic synapse
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04720 Long-term potentiation
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04730 Long-term depression
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05205 Proteoglycans in cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05208 Chemical carcinogenesis - reactive oxygen species
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  09162 Cancer: specific types
   05210 Colorectal cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05212 Pancreatic cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05225 Hepatocellular carcinoma
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05226 Gastric cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05214 Glioma
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05221 Acute myeloid leukemia
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05220 Chronic myeloid leukemia
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05218 Melanoma
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05211 Renal cell carcinoma
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05219 Bladder cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05215 Prostate cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05213 Endometrial cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05224 Breast cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05223 Non-small cell lung cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  09172 Infectious disease: viral
   05161 Hepatitis B
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05160 Hepatitis C
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05022 Pathways of neurodegeneration - multiple diseases
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  09165 Substance dependence
   05034 Alcoholism
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   01522 Endocrine resistance
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
Genes
HSA: 369(ARAF)
PTR: 100614256(ARAF)
PPS: 100990590(ARAF)
GGO: 101134493(ARAF)
PON: 100431871(ARAF)
PPYG: 129024440(ARAF)
NLE: 100595311(ARAF)
HMH: 116811640(ARAF)
SSYN: 129476389(ARAF)
MCC: 707169(ARAF)
MCF: 101925249(ARAF)
MTHB: 126945567
MNI: 105463916(ARAF)
CSAB: 103231895(ARAF)
CATY: 105590503(ARAF)
PANU: 101019640(ARAF)
TGE: 112616121(ARAF)
MLEU: 105541693(ARAF)
RRO: 104664593(ARAF)
RBB: 108530908(ARAF)
TFN: 117078298(ARAF)
PTEH: 111536410(ARAF)
CANG: 105509473(ARAF)
CJC: 100387961(ARAF)
SBQ: 101043605(ARAF)
CIMI: 108295532(ARAF)
ANAN: 105734540(ARAF)
CSYR: 103270865(ARAF)
MMUR: 105862190(ARAF)
LCAT: 123628637(ARAF)
PCOQ: 105816815(ARAF)
OGA: 100947929(ARAF)
MMU: 11836(Araf)
MCAL: 110287540(Araf)
MPAH: 110314283(Araf)
RNO: 64363(Araf)
MCOC: 116073820(Araf)
ANU: 117694504(Araf)
MUN: 110541705(Araf)
CGE: 100751432(Araf)
MAUA: 101826679(Araf)
PLEU: 114703900(Araf)
MFOT: 126496069
AAMP: 119805132(Araf)
NGI: 103741627(Araf)
HGL: 101723157(Araf)
CPOC: 100727629(Araf)
CCAN: 109696670(Araf)
DORD: 106000303(Araf)
DSP: 122098764(Araf)
PLOP: 125343344(Araf)
NCAR: 124971762
MMMA: 107144326(Araf)
OCU: 100340437
OPI: 101529871(ARAF)
TUP: 102493239(ARAF)
GVR: 103594183(ARAF)
CFA: 491857(ARAF)
CLUD: 112673245(ARAF)
VVP: 112907269(ARAF)
VLG: 121483180(ARAF)
NPO: 129518309(ARAF)
AML: 100475955(ARAF)
UMR: 103664348(ARAF)
UAH: 113265980(ARAF)
UAR: 123786515(ARAF)
ELK: 111150582
LLV: 125091395
MPUF: 101687799(ARAF)
MNP: 132007524(ARAF)
MLK: 131821130(ARAF)
NVS: 122897579(ARAF)
ORO: 101372839(ARAF)
EJU: 114216801(ARAF)
ZCA: 113930205(ARAF)
MLX: 118009801(ARAF)
NSU: 110571460(ARAF)
LWW: 102736249(ARAF)
FCA: 101089839(ARAF)
PYU: 121026094(ARAF)
PCOO: 112870575(ARAF)
PBG: 122477714(ARAF)
PVIV: 125157334(ARAF)
LRUF: 124509491
PTG: 102956086(ARAF)
PPAD: 109248156(ARAF)
PUC: 125931647
AJU: 106972677
HHV: 120219872(ARAF)
BTA: 540421(ARAF)
BOM: 102285079(ARAF)
BIU: 109555027(ARAF)
BBUB: 102392863(ARAF)
BBIS: 104999018
CHX: 102169370(ARAF)
OAS: 100305131(ARAF)
BTAX: 128070468(ARAF)
ODA: 120882071(ARAF)
CCAD: 122434589(ARAF)
MBEZ: 129564326(ARAF)
SSC: 397601(ARAF)
CFR: 102506774(ARAF)
CBAI: 105079376(ARAF)
CDK: 105102848(ARAF)
VPC: 102529339(ARAF)
BACU: 103020975(ARAF)
BMUS: 118888277(ARAF)
LVE: 103090018(ARAF)
OOR: 101271966(ARAF)
DLE: 111165554(ARAF)
PCAD: 102974274(ARAF)
PSIU: 116747370(ARAF)
NASI: 112402589(ARAF)
ECB: 100061212(ARAF)
EAI: 106847984(ARAF)
MYB: 102241454(ARAF)
MYD: 102755690(ARAF)
MMYO: 118653778(ARAF)
MLF: 102420799(ARAF)
MDT: 132224643(ARAF)
PKL: 118731760(ARAF)
EFUS: 103296401(ARAF)
MNA: 107541381(ARAF)
DRO: 112322484(ARAF)
SHON: 118998301(ARAF)
AJM: 119060144(ARAF)
PDIC: 114504860(ARAF)
PHAS: 123832643(ARAF)
MMF: 118635666(ARAF)
PPAM: 129065223(ARAF)
HAI: 109376563(ARAF)
RFQ: 117022263(ARAF)
PALE: 102877877(ARAF)
PGIG: 120605533(ARAF)
PVP: 105305459(ARAF)
RAY: 107509353(ARAF)
MJV: 108398550(ARAF)
TOD: 119246187(ARAF)
SARA: 101554406(ARAF)
SETR: 125999333(ARAF)
LAV: 100671404(ARAF)
TMU: 101351589
ETF: 101648298(ARAF)
DNM: 101419167(ARAF)
MDO: 100017615(ARAF)
GAS: 123253593(ARAF)
SHR: 100913901(ARAF)
AFZ: 127543183
PCW: 110201017(ARAF)
TVP: 118832833(ARAF)
OAA: 100084423(ARAF)
CCAY: 125628410(ARAF)
DCC: 119847238(ARAF)
CPIC: 101949192(ARAF)
CABI: 116817290
MRV: 120388490(ARAF)
ACS: 100562070(araf)
ASAO: 132767633(ARAF)
PVT: 110081172(ARAF)
SUND: 121923177(ARAF)
PBI: 103066155(ARAF)
PMUR: 107297295(ARAF)
CTIG: 120306657(ARAF)
TSR: 106553001
PGUT: 117675400(ARAF)
APRI: 131191616(ARAF)
PTEX: 113443282(ARAF)
NSS: 113417793(ARAF)
VKO: 123024016(ARAF)
PMUA: 114587447(ARAF)
PRAF: 128404741(ARAF)
ZVI: 118097605(ARAF)
HCG: 128344467(ARAF)
GJA: 107119310(ARAF) 107120717
STOW: 125429274(ARAF)
EMC: 129346271(ARAF)
XLA: 398892(araf.L) 399056(araf.S)
XTR: 100495479(araf)
NPR: 108801347(ARAF)
RTEM: 120913987(ARAF)
BBUF: 120978227(ARAF) 121005800
BGAR: 122922903 122946066(ARAF)
MUO: 115463424(ARAF)
GSH: 117350098(ARAF)
DRE: 403063(araf)
SRX: 107709867 107750175
SANH: 107672764 107673380
SGH: 107592338 107595004
CCAR: 109065600 109092279
CAUA: 113049421 113091344
CGIB: 127957206 128010014
PTET: 122345507(araf)
LROH: 127165632(araf)
OMC: 131541667(araf)
PPRM: 120470201(araf)
MAMB: 125266490(araf)
CIDE: 127512955
CERY: 137033785(araf)
MASI: 127428261 127436698
TROS: 130565845(araf)
TDW: 130418981(araf)
MANU: 129440088(araf)
IPU: 108255753(araf)
IFU: 128625606(araf)
PHYP: 113542410
SMEO: 124380566(araf)
TFD: 113639392(araf)
TVC: 132855403(araf)
TRN: 134335075(araf)
AMEX: 103043654(araf)
CMAO: 118827772(araf)
EEE: 113588109(araf)
CHAR: 105890001(araf)
TRU: 654307(araf)
TFS: 130526499(araf)
TNG: GSTEN00020048G001
LCO: 104930864
NCC: 104953267
TBEN: 117473092(araf)
PGEO: 117452438
GACU: 117541187(araf)
EMAC: 134873719(araf)
ELY: 117252832(araf)
EFO: 125890244(araf)
PLEP: 121943992(araf)
SLUC: 116050444(araf)
ECRA: 117944848(araf)
ESP: 116689928(araf)
PFLV: 114555276(araf)
GAT: 120830450(araf)
PPUG: 119224747(araf)
AFB: 129101790(araf)
CLUM: 117735957(araf)
PSWI: 130196479(araf)
MSAM: 119891482(araf)
SCHU: 122876305(araf)
CUD: 121509700(araf)
ALAT: 119019813(araf)
MZE: 101471760
ONL: 100698373
OAU: 116316356(araf)
OLA: 101159594(araf)
OML: 112137697(araf)
CSAI: 133450793(araf)
XMA: 102235904
XCO: 114154407
XHE: 116729539
PRET: 103469576
PFOR: 103141909(araf)
PLAI: 106956161(araf)
PMEI: 106930520
GAF: 122827739(araf)
PPRL: 129351582(araf)
CVG: 107104990
CTUL: 119775797(araf)
GMU: 124878222(araf)
NFU: 107393473(araf)
KMR: 108249882(araf)
ALIM: 106533959(araf)
NWH: 119412941(araf)
AOCE: 111568015
MCEP: 125012267(araF)
CSEM: 103397124 103397571
POV: 109633665
SSEN: 122769858(araf)
HHIP: 117767832(araf)
HSP: 118114645(araf)
PPLT: 128438302(araf)
SMAU: 118314403(araf)
LCF: 108878154
SDU: 111227828
SLAL: 111647945
XGL: 120805159(araf)
HCQ: 109510536
SSCV: 125994756
SBIA: 133499160(araf)
PEE: 133400428(araf)
PTAO: 133474590(araf)
BPEC: 110162179
MALB: 109959639
BSPL: 114845646(araf)
SJO: 128364280(araf)
SASA: 106580530 106585138
STRU: 115164256 115200393
OTW: 112248687(araf) 112265332
OMY: 110525904(araf) 110536286
OGO: 124034135(araf) 124036513
ONE: 115111809 115140270
OKI: 109882485 109896112
OKE: 118358512 118393428(araf)
SALP: 111957871 111973909
SNH: 120041600(araf) 120063367
CCLU: 121530684 121585055(araf)
ELS: 105014388(araf)
SFM: 108931249(araf)
PKI: 111844715(araf)
AANG: 118208073(araf)
LOC: 102687735
PSPA: 121305491 121329240(araf)
ARUT: 117401630(araf) 117967710
PSEX: 120542924(araf)
LCM: 102351967
HOC: 132814149
TPRE: 106652672
DFR: 124498302
XEN: 124459479
 » show all
Reference
PMID:8020955
  Authors
Lee JE, Beck TW, Brennscheidt U, DeGennaro LJ, Rapp UR
  Title
The complete sequence and promoter activity of the human A-raf-1 gene (ARAF1).
  Journal
Genomics 20:43-55 (1994)
DOI:10.1006/geno.1994.1125
  Sequence
[hsa:369]
Reference
PMID:20674547
  Authors
Roskoski R Jr
  Title
RAF protein-serine/threonine kinases: structure and regulation.
  Journal
Biochem Biophys Res Commun 399:313-7 (2010)
DOI:10.1016/j.bbrc.2010.07.092

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Pathway (72)   
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Disease (1)   
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Chemical reaction (1)   
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Gene (549)   
   KEGG GENES (331)   
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