KEGG ORTHOLOGY: K04386

ORTHOLOGY: K04386

Entry

K04386                      KO

Symbol

IL1R1, CD121a

Name

interleukin 1 receptor type I

Pathway

map04010

MAPK signaling pathway

map04060

Cytokine-cytokine receptor interaction

map04064

NF-kappa B signaling pathway

map04380

Osteoclast differentiation

map04640

Hematopoietic cell lineage

map04659

Th17 cell differentiation

map04750

Inflammatory mediator regulation of TRP channels

map05130

Pathogenic Escherichia coli infection

map05131

Shigellosis

map05146

Amoebiasis

map05163

Human cytomegalovirus infection

map05166

Human T-cell leukemia virus 1 infection

map05418

Fluid shear stress and atherosclerosis

Disease

H01117

Chronic recurrent multifocal osteomyelitis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
   04064 NF-kappa B signaling pathway
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
   04659 Th17 cell differentiation
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
   05163 Human cytomegalovirus infection
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
   05131 Shigellosis
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
   04090 CD molecules
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
Cytokine receptors [BR:ko04050]
Interleukin receptor families
  IL1 receptor family
   K04386  IL1R1, CD121a; interleukin 1 receptor type I
CD molecules [BR:ko04090]
Proteins
  K04386  CD121a, IL1R1; interleukin 1 receptor, type I

Other DBs

GO:

0004909

Genes

HSA:	3554(IL1R1)

PTR:	459460(IL1R1)

PPS:	100972617(IL1R1)

GGO:	101133600(IL1R1)

PPYG:

129030563(IL1R1)

NLE:	100586658(IL1R1)

HMH:	116483372(IL1R1)

SSYN:

129462244(IL1R1)

MCC:	711726(IL1R1)

MCF:	102146317(IL1R1)

MTHB:

126934234

MNI:	105490126(IL1R1)

CSAB:

103241149(IL1R1)

CATY:

105583647(IL1R1)

PANU:

101003909(IL1R1)

TGE:	112604908(IL1R1)

MLEU:

105531618(IL1R1)

RRO:	104680311(IL1R1)

RBB:	108524091(IL1R1)

TFN:	117062283(IL1R1)

PTEH:

111542169(IL1R1)

CANG:

105522167(IL1R1)

CJC:	100393945(IL1R1)

SBQ:	101031937(IL1R1)

CIMI:

108317428(IL1R1)

ANAN:

105730378(IL1R1)

CSYR:

103260528(IL1R1)

MMUR:

105857833(IL1R1)

LCAT:

123637267(IL1R1)

PCOQ:

105808263(IL1R1)

OGA:	100959140(IL1R1)

MMU:	16177(Il1r1)

MCAL:

110293878(Il1r1)

MPAH:

110321407(Il1r1)

RNO:	25663(Il1r1)

MCOC:

116088348(Il1r1)

ANU:	117722628(Il1r1)

MUN:	110559960(Il1r1)

CGE:	100758740(Il1r1)

MAUA:

101823176(Il1r1)

PROB:

127236676(Il1r1)

PLEU:

114690812(Il1r1)

MORG:

121450585(Il1r1)

MFOT:

126496981

AAMP:

119822271(Il1r1)

NGI:	103744180(Il1r1)

HGL:	101711273(Il1r1)

CPOC:

100724206(Il1r1)

CCAN:

109682273(Il1r1)

DORD:

105988260(Il1r1)

DSP:	122121295(Il1r1)

PLOP:

125356117(Il1r1)

NCAR:

124962993

MMMA:

107158523(Il1r1)

OCU:

100352905

OPI:	101519459(IL1R1)

TUP:	102492414(IL1R1)

GVR:	103610948(IL1R1)

CFA:	481328(IL1R1)

CLUD:

112669932(IL1R1)

VVP:	112915144(IL1R1)

VLG:	121490366(IL1R1)

NPO:	129511738(IL1R1)

AML:	100472991(IL1R1)

UMR:	103670641(IL1R1)

UAH:	113247336(IL1R1)

UAR:	123775960(IL1R1)

ELK:

111155931

LLV:

125108912

MPUF:

101670524(IL1R1)

MNP:	132021637(IL1R1)

MLK:	131808468(IL1R1)

NVS:	122916395(IL1R1)

ORO:	101381751(IL1R1)

EJU:	114209829(IL1R1)

ZCA:	113938587(IL1R1)

MLX:	118008270(IL1R1)

NSU:	110572074(IL1R1)

LWW:	102741586(IL1R1)

FCA:	101080705(IL1R1)

PYU:	121016438(IL1R1)

PCOO:

112868908(IL1R1)

PBG:	122496688(IL1R1)

PVIV:

125162886(IL1R1)

LRUF:

124502907

PTG:	102958342(IL1R1)

PPAD:

109254564(IL1R1)

PUC:

125936904

AJU:

106968747

HHV:	120245902(IL1R1)

BTA:	515640(IL1R1)

BOM:	102271047(IL1R1)

BIU:	109565502(IL1R1)

BBUB:

102402346(IL1R1)

BBIS:

104980851(IL1R1)

CHX:	102187231(IL1R1)

OAS:	101103054(IL1R1)

BTAX:

128056062(IL1R1)

ODA:	120883612(IL1R1)

CCAD:

122441438(IL1R1)

MBEZ:

129539363(IL1R1)

SSC:	100626904(IL1R1)

CFR:	102503597(IL1R1)

CBAI:

105072217(IL1R1)

CDK:	105099109(IL1R1)

VPC:	102544667(IL1R1)

BACU:

102998234(IL1R1)

BMUS:

118905985(IL1R1)

LVE:

103084028

OOR:	101277609(IL1R1)

DLE:	111187389(IL1R1)

PCAD:

102973768(IL1R1)

PSIU:

116763886(IL1R1)

NASI:

112399067(IL1R1)

ECB:	100009699(IL1R1)

EPZ:	103563183(IL1R1)

EAI:	106839400(IL1R1)

MYB:	102238676(IL1R1)

MYD:	102775132(IL1R1)

MMYO:

118679042(IL1R1)

MLF:

102437031

MDT:	132212977(IL1R1)

PKL:	118727943(IL1R1)

EFUS:

103296831(IL1R1)

MNA:	107532712(IL1R1)

DRO:	112315147(IL1R1)

SHON:

118994653(IL1R1)

AJM:	119047918(IL1R1) 119047921

PDIC:

114499425(IL1R1)

PHAS:

123811594(IL1R1)

MMF:	118631025(IL1R1)

PPAM:

129074255(IL1R1)

HAI:	109395478(IL1R1)

RFQ:	117033297(IL1R1)

PALE:

102884439(IL1R1)

PGIG:

120584449(IL1R1)

PVP:	105298727(IL1R1)

RAY:	107498102(IL1R1)

MJV:	108404707(IL1R1)

TOD:	119259279(IL1R1)

SARA:

101537237(IL1R1)

SETR:

126024218(IL1R1)

LAV:	100657834(IL1R1)

TMU:

101358013

ETF:	101660872(IL1R1)

DNM:	101447218(IL1R1)

MDO:	100017751(IL1R1)

GAS:	123241763(IL1R1)

SHR:

100913514

AFZ:

127553548

PCW:	110209396(IL1R1)

TVP:	118846409(IL1R1)

OAA:	100084073(IL1R1)

GGA:	396481(IL1R1)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

CATA:

AFUL:

TGU:	100220817(IL1R1)

LSR:

SCAN:

PMOA:

OTC:

PRUF:

GFR:	102040488(IL1R1)

FAB:	101815105(IL1R1)

OMA:

130249342

PHI:	102106217(IL1R1)

PMAJ:

107210317

CCAE:

111942272

CCW:	104686063(IL1R1)

CBRC:

103617523(IL1R1)

ETL:

114068702

ZAB:	102065213(IL1R1)

ZLE:	135446540(IL1R1)

ACHL:

SVG:

MMEA:

HRT:

SATI:

FPG:

FCH:

CCRI:

NNT:	104401645(IL1R1)

SHAB:

115603664

ACUN:

113484904(IL1R1)

TALA:

104356295

ACHC:

115334517(IL1R1)

HALD:

HLE:

AGEN:

GCL:

CSTI:

LDI:

MNB:	103773004 103775967

DPUB:

AVIT:

BRHI:

EGZ:

NNI:

PCRI:

104025350(IL1R1)

PCAO:

104039648(IL1RL2)

PADL:

103918827

AFOR:

103896288

FGA:	104080987(IL1RL2)

GSTE:

104250733(IL1RL2)

CLV:	102097520(IL1R1)

MUI:	104534625(IL1R1)

PGUU:

PLET:

CMAC:

CUCA:

TEO:

BREG:

OHA:

ACAR:

CPEA:

CVF:

RTD:

AAM:	106494064(IL1R1)

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:	102558564(IL1R1)

CPOO:

109306229 109306232

GGN:	109303109 109303181(IL1RL2)

PSS:

102463929

CMY:

102937532

CCAY:

125639791 125639813

DCC:	119851624 119852824

CPIC:

101942308

TST:	117870720 117870722

CABI:

116832859(IL1R1) 116832861

MRV:	120395314 120406214

ACS:

100553004

ASAO:

132771568(IL1R1) 132771569

PVT:

SUND:

PBI:

PMUR:

CTIG:

PGUT:

APRI:

PTEX:

NSS:	113411623 113411624

VKO:	123025377 123025408

PMUA:

114596401(IL1R1)

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:	129325912 129326742

XLA:	108708404 108708405 108709706(il1r1.S)

XTR:	100491546(il1r1)

RTEM:

120926475(IL1R1)

BBUF:

120995678 120995680

BGAR:

122931522 122931549(IL1R1)

MUO:	115468036 115469120

GSH:	117362265 117362917 117363168

DRE:	799204(zmp:0000000936) 799279

SRX:	107714880 107714881 107722700 107722706

SANH:

107673960 107675133 107675134 107687390

SGH:	107558386 107567423 107567433

CCAR:

109066880 109066881

CAUA:

113052915 113053710 113108221 113108224 113108225 113109285

CGIB:

127965578(zmp:0000000936) 127965580 127965582 128020259 128020260

PTET:

122333088(zmp:0000000936) 122333089

LROH:

127171275(zmp:0000000936) 127171365

OMC:	131546853(zmp:0000000936) 131547004

PPRM:

120479173(zmp:0000000936) 120479174

RKG:	130076012(zmp:0000000936)

MAMB:

125270894 125270896 125270897

CIDE:

127518735(zmp:0000000936) 127518736

CERY:

137035366(il1rl2) 137036287

MASI:

127446922 127447613 127448252(zmp:0000000936) 127448253

TROS:

130555423 130555687(zmp:0000000936)

TDW:	130427374(zmp:0000000936) 130428063

MANU:

129451532(zmp:0000000936) 129451721

IPU:	108259002 108266615

IFU:	128602526 128608567 128608568(zmp:0000000936)

PHYP:

113537579 113544722

SMEO:

124377808 124382274 124383179(zmp:0000000936)

TFD:	113646269 113646273(zmp:0000000936) 113648674

TVC:	132839811 132849867 132849870(zmp:0000000936)

TRN:	134324022 134324436(zmp:0000000936) 134329299

AMEX:

103036820 111196468

CMAO:

118798130 118801536(zmp:0000000936) 118801537

EEE:	113575388 113580350

CHAR:

105909637(zmp:0000000936) 105909647

TRU:

TFS:

LCO:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:	108244190 108249357

ALIM:

NWH:

AOCE:

MCEP:

CSEM:

SSEN:

HHIP:

HSP:

PPLT:

SMAU:

LCF:	108897015 108897019 108897039

SDU:	111218164 111218165 111218892

SLAL:

111650531 111650536 111650537

XGL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

MALB:

BSPL:

SJO:

SASA:

100136530(il-1rl) 106582258 106586476

STRU:

115161013

OTW:	112231472 112234773 112239331 112239342(zmp:0000000936)

OMY:	100136037(il-1r1) 110502091 110520326(zmp:0000000936)

OGO:

ONE:

OKI:

OKE:

SALP:

SNH:

CCLU:

ELS:	105016333 105016334 105016335

SFM:	108922268 108926930

PKI:	111854121 111860702

AANG:

118224403

LOC:	102698856 102699051

PSPA:

121320452 121320457 121327678

ARUT:

117405220

LCM:	102358615 102365673

CMK:

RTP:

CPLA:

HOC:

LERI:

HAME:

Reference

PMID:2532321

Authors

Chua AO, Gubler U

Title

Sequence of the cDNA for the human fibroblast type interleukin-1 receptor.

Journal

Nucleic Acids Res 17:10114 (1989)
DOI:10.1093/nar/17.23.10114

Sequence

[hsa:3554]

Reference

PMID:10671496

Authors

Slack JL, Schooley K, Bonnert TP, Mitcham JL, Qwarnstrom EE, Sims JE, Dower SK

Title

Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways.

Journal

J Biol Chem 275:4670-8 (2000)
DOI:10.1074/jbc.275.7.4670

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (26)   
   KEGG PATHWAY (26)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (2)   
   KEGG DRUG (2)   
Gene (551)   
   KEGG GENES (495)   
   KEGG MGENES (54)   
   RefGene (1)   
   OC (1)   
Literature (2)   
   PubMed (2)   
All databases (586)   

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