KEGG   ORTHOLOGY: K04386
Entry
K04386                      KO                                     

Name
IL1R1, CD121a
Definition
interleukin 1 receptor type I
Pathway
ko04010  MAPK signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04064  NF-kappa B signaling pathway
ko04380  Osteoclast differentiation
ko04640  Hematopoietic cell lineage
ko04659  Th17 cell differentiation
ko04750  Inflammatory mediator regulation of TRP channels
ko05130  Pathogenic Escherichia coli infection
ko05131  Shigellosis
ko05146  Amoebiasis
ko05163  Human cytomegalovirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05418  Fluid shear stress and atherosclerosis
Disease
H01492  Systemic sclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
   04064 NF-kappa B signaling pathway
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
   04659 Th17 cell differentiation
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
 09160 Human Diseases
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
   05131 Shigellosis
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
   05163 Human cytomegalovirus infection
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
   04090 CD molecules
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
Cytokine receptors [BR:ko04050]
 Interleukin receptor families
  IL1 receptor family
   K04386  IL1R1, CD121a; interleukin 1 receptor type I
CD molecules [BR:ko04090]
 Proteins
  K04386  CD121a, IL1R1; interleukin 1 receptor, type I
Other DBs
GO: 0004909
Genes
HSA: 3554(IL1R1)
PTR: 459460(IL1R1)
PPS: 100972617(IL1R1)
GGO: 101133600(IL1R1)
PON: 100172810(IL1R1)
NLE: 100586658(IL1R1)
MCC: 711726(IL1R1)
MCF: 102146317(IL1R1)
CSAB: 103241149(IL1R1)
RRO: 104680311(IL1R1)
RBB: 108524091(IL1R1)
CJC: 100393945(IL1R1)
SBQ: 101031937(IL1R1)
MMU: 16177(Il1r1)
MCAL: 110293878(Il1r1)
MPAH: 110321407(Il1r1)
RNO: 25663(Il1r1)
CGE: 100758740(Il1r1)
NGI: 103744180(Il1r1)
HGL: 101711273(Il1r1)
CCAN: 109682273(Il1r1)
OCU: 100352905(IL1R1)
TUP: 102492414(IL1R1)
CFA: 481328(IL1R1)
VVP: 112915144(IL1R1)
AML: 100472991(IL1R1)
UMR: 103670641(IL1R1)
UAH: 113247336(IL1R1)
ORO: 101381751(IL1R1)
ELK: 111155931
FCA: 101080705(IL1R1)
PTG: 102958342(IL1R1)
PPAD: 109254564(IL1R1)
AJU: 106968747(IL1R1)
BTA: 515640(IL1R1)
BOM: 102271047(IL1R1)
BIU: 109565502(IL1R1)
BBUB: 102402346(IL1R1)
CHX: 102187231(IL1R1)
OAS: 101103054(IL1R1)
SSC: 100626904(IL1R1)
CFR: 102503597(IL1R1)
CDK: 105099109(IL1R1)
BACU: 102998234(IL1R1)
LVE: 103084028
OOR: 101277609(IL1R1)
DLE: 111187389(IL1R1)
PCAD: 102973768(IL1R1)
ECB: 100009699(IL1R1)
EPZ: 103563183(IL1R1)
EAI: 106839400(IL1R1)
MYB: 102238676(IL1R1)
MYD: 102775132(IL1R1)
MNA: 107532712(IL1R1)
HAI: 109395478(IL1R1)
DRO: 112315147(IL1R1)
PALE: 102884439(IL1R1)
RAY: 107498102(IL1R1)
MJV: 108404707(IL1R1)
LAV: 100657834(IL1R1)
TMU: 101358013
MDO: 100017751(IL1R1)
SHR: 100913514
PCW: 110209396(IL1R1)
OAA: 100084073(IL1R1)
GGA: 396481(IL1R1)
MGP: 100540676
CJO: 107306834
NMEL: 110406790
APLA: 101794055 101795572(IL1RL1)
ACYG: 106041672
TGU: 100220817(IL1R1)
LSR: 110474740
SCAN: 103812363
GFR: 102040488(IL1R1)
FAB: 101815105(IL1R1)
PHI: 102106217(IL1R1)
PMAJ: 107210317
CCAE: 111942272
CCW: 104686063
ETL: 114068702
FPG: 101912007
FCH: 102060155
CLV: 102097520(IL1R1)
EGZ: 104126373(IL1RL1) 104126375
NNI: 104019340
ACUN: 113484904(IL1R1)
PADL: 103918827 103918873(IL1RL1)
AAM: 106494064(IL1R1)
ASN: 102377912
AMJ: 102558564(IL1R1)
PSS: 102463929
CMY: 102937532
CPIC: 101942308(IL1R1)
ACS: 100553004
PVT: 110090152
PBI: 112542425
PMUR: 107288201
PMUA: 114596401(IL1R1)
GJA: 107110211
XTR: 100491546(il1r1)
DRE: 799204(zmp:0000000936) 799279
LCO: 104928679
MZE: 101470103
ONL: 100702660
OLA: 101157257
XMA: 102235704
XCO: 114148728
NFU: 107389426
AOCE: 111563964
CSEM: 103391984
HCQ: 109522385
BPEC: 110169112
MALB: 109968094
CMK: 103172493
 » show all
Reference
PMID:2532321
  Authors
Chua AO, Gubler U
  Title
Sequence of the cDNA for the human fibroblast type interleukin-1 receptor.
  Journal
Nucleic Acids Res 17:10114 (1989)
DOI:10.1093/nar/17.23.10114
  Sequence
[hsa:3554]
Reference
  Authors
Slack JL, Schooley K, Bonnert TP, Mitcham JL, Qwarnstrom EE, Sims JE, Dower SK
  Title
Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways.
  Journal
J Biol Chem 275:4670-8 (2000)
DOI:10.1074/jbc.275.7.4670

KEGG   ORTHOLOGY: K04387
Entry
K04387                      KO                                     

Name
IL1R2, CD121b
Definition
interleukin 1 receptor type II
Pathway
ko04060  Cytokine-cytokine receptor interaction
ko04640  Hematopoietic cell lineage
ko05146  Amoebiasis
ko05166  Human T-cell leukemia virus 1 infection
ko05202  Transcriptional misregulation in cancer
ko05215  Prostate cancer
ko05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04387  IL1R2, CD121b; interleukin 1 receptor type II
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K04387  IL1R2, CD121b; interleukin 1 receptor type II
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K04387  IL1R2, CD121b; interleukin 1 receptor type II
  09162 Cancer: specific types
   05215 Prostate cancer
    K04387  IL1R2, CD121b; interleukin 1 receptor type II
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04387  IL1R2, CD121b; interleukin 1 receptor type II
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04387  IL1R2, CD121b; interleukin 1 receptor type II
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K04387  IL1R2, CD121b; interleukin 1 receptor type II
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K04387  IL1R2, CD121b; interleukin 1 receptor type II
   04090 CD molecules
    K04387  IL1R2, CD121b; interleukin 1 receptor type II
Cytokine receptors [BR:ko04050]
 Interleukin receptor families
  IL1 receptor family
   K04387  IL1R2, CD121b; interleukin 1 receptor type II
CD molecules [BR:ko04090]
 Proteins
  K04387  CD121b, IL1R2; interleukin 1 receptor, type II
Other DBs
GO: 0004910
Genes
HSA: 7850(IL1R2)
PTR: 470455(IL1R2)
PPS: 100972054(IL1R2)
GGO: 101132361(IL1R2)
PON: 100440034(IL1R2)
NLE: 100586097(IL1R2)
MCC: 711638(IL1R2)
MCF: 102143926(IL1R2)
CSAB: 103241146(IL1R2)
RRO: 104680312(IL1R2)
RBB: 108524092(IL1R2)
CJC: 100393582(IL1R2)
SBQ: 101032260(IL1R2)
MMU: 16178(Il1r2)
MCAL: 110302131(Il1r2)
MPAH: 110322453(Il1r2)
RNO: 117022(Il1r2)
MUN: 110561822(Il1r2)
CGE: 100759030(Il1r2)
NGI: 103744179(Il1r2)
HGL: 101710536(Il1r2)
CCAN: 109682276(Il1r2)
OCU: 100344048(IL1R2)
TUP: 102491995(IL1R2)
CFA: 481330(IL1R2)
VVP: 112915145(IL1R2)
AML: 100475938(IL1R2)
UMR: 103670643(IL1R2)
UAH: 113247309(IL1R2)
ORO: 101381470(IL1R2)
ELK: 111155901
FCA: 101080961(IL1R2)
PTG: 102959004(IL1R2)
PPAD: 109254568(IL1R2)
AJU: 106968746(IL1R2)
BTA: 515700(IL1R2)
BOM: 102271891(IL1R2)
BIU: 109565866(IL1R2)
BBUB: 102401594(IL1R2)
CHX: 102186601(IL1R2)
OAS: 101103308(IL1R2)
SSC: 100628112(IL1R2)
CFR: 102505984(IL1R2)
CDK: 105099111(IL1R2)
BACU: 102999629(IL1R2)
LVE: 103069948
OOR: 101276960(IL1R2)
DLE: 111187494(IL1R2)
PCAD: 102973842(IL1R2)
ECB: 100033831(IL1R2)
EPZ: 103559218(IL1R2)
EAI: 106839396(IL1R2)
MYB: 102239307(IL1R2)
MYD: 102774276(IL1R2)
MNA: 107532703(IL1R2)
HAI: 109395468(IL1R2)
DRO: 112315222(IL1R2)
PALE: 102884188(IL1R2)
RAY: 107498113(IL1R2)
MJV: 108404710(IL1R2)
LAV: 100667125(IL1R2)
TMU: 101344340
MDO: 100017640(IL1R2)
SHR: 100913252(IL1R2)
PCW: 110209394(IL1R2)
OAA: 100084042(IL1R2)
GGA: 418715(IL1R2)
MGP: 100542672(IL1R2)
CJO: 107306854(IL1R2)
NMEL: 110406769(IL1R2)
APLA: 101793878(IL1R2)
ACYG: 106041632(IL1R2)
TGU: 100230419(IL1R2)
LSR: 110474960(IL1R2)
SCAN: 103812645(IL1R2)
GFR: 102034720(IL1R2)
FAB: 101815893(IL1R2)
PHI: 102109460(IL1R2)
PMAJ: 107213480(IL1R2)
CCAE: 111922338(IL1R2)
CCW: 104686062(IL1R2)
ETL: 114069084(IL1R2)
FPG: 101912185(IL1R2)
FCH: 102059985(IL1R2)
CLV: 102086040
EGZ: 104126402(IL1R2)
NNI: 104019397(IL1R2)
ACUN: 113486165(IL1R2)
PADL: 103918872(IL1R2)
AAM: 106493981(IL1R2)
ASN: 102377367
AMJ: 102558781(IL1R2)
PSS: 102447027(IL1R2)
CMY: 102937756(IL1R2)
CPIC: 101942576(IL1R2)
ACS: 100553195(il1r2)
PVT: 110090149(IL1R2)
PBI: 103053232(IL1R2)
PMUR: 107286533
TSR: 106549293
PMUA: 114596486(IL1R2)
GJA: 107120036
XLA: 108708406(il1r2.L)
XTR: 548430(il1r2)
NPR: 108785107(IL1R2)
SRX: 107726157
SGH: 107559212
IPU: 108266111
PHYP: 113544560
AMEX: 103043694
EEE: 113575382
TRU: 101071789(il1r2)
LCO: 104918238
OLA: 101157738
XMA: 102224450(il1r2) 111608367
XCO: 114148816
PRET: 103478386(il1r2)
CVG: 107101752
KMR: 108244193
ALIM: 106517220
CSEM: 103391610
POV: 109642053
LCF: 108897018 108897084(il1r2)
SDU: 111218441
SLAL: 111650527
HCQ: 109522273(il1r2)
BPEC: 110169109
MALB: 109974022(il1r2)
SASA: 100270808(il1r2)
OTW: 112239371
SFM: 108926886(il1r2)
PKI: 111854113
LCM: 102361020(IL1R2)
CMK: 103172482
 » show all
Reference
PMID:1833184
  Authors
McMahan CJ, Slack JL, Mosley B, Cosman D, Lupton SD, Brunton LL, Grubin CE, Wignall JM, Jenkins NA, Brannan CI, et al.
  Title
A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.
  Journal
EMBO J 10:2821-32 (1991)
DOI:10.1002/j.1460-2075.1991.tb07831.x
  Sequence
[hsa:7850]
Reference
PMID:9862719
  Authors
Lang D, Knop J, Wesche H, Raffetseder U, Kurrle R, Boraschi D, Martin MU.
  Title
The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness.
  Journal
J Immunol 161:6871-7 (1998)

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