KEGG   ORTHOLOGY: K04388
Entry
K04388                      KO                                     
Symbol
TGFBR2
Name
TGF-beta receptor type-2 [EC:2.7.11.30]
Pathway
map04010  MAPK signaling pathway
map04060  Cytokine-cytokine receptor interaction
map04068  FoxO signaling pathway
map04144  Endocytosis
map04218  Cellular senescence
map04350  TGF-beta signaling pathway
map04380  Osteoclast differentiation
map04390  Hippo signaling pathway
map04520  Adherens junction
map04659  Th17 cell differentiation
map04926  Relaxin signaling pathway
map04933  AGE-RAGE signaling pathway in diabetic complications
map05142  Chagas disease
map05161  Hepatitis B
map05166  Human T-cell leukemia virus 1 infection
map05200  Pathways in cancer
map05202  Transcriptional misregulation in cancer
map05210  Colorectal cancer
map05212  Pancreatic cancer
map05220  Chronic myeloid leukemia
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05415  Diabetic cardiomyopathy
Disease
H00017  Esophageal cancer
H00020  Colorectal cancer
H00048  Hepatocellular carcinoma
H00800  Loeys-Dietz syndrome
H00801  Familial thoracic aortic aneurysm and dissection
H02565  Hereditary nonpolyposis colorectal cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
   04350 TGF-beta signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
   04390 Hippo signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
   04068 FoxO signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04388  TGFBR2; TGF-beta receptor type-2
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04388  TGFBR2; TGF-beta receptor type-2
  09143 Cell growth and death
   04218 Cellular senescence
    K04388  TGFBR2; TGF-beta receptor type-2
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04388  TGFBR2; TGF-beta receptor type-2
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K04388  TGFBR2; TGF-beta receptor type-2
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04388  TGFBR2; TGF-beta receptor type-2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05202 Transcriptional misregulation in cancer
    K04388  TGFBR2; TGF-beta receptor type-2
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05212 Pancreatic cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05225 Hepatocellular carcinoma
    K04388  TGFBR2; TGF-beta receptor type-2
   05226 Gastric cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05220 Chronic myeloid leukemia
    K04388  TGFBR2; TGF-beta receptor type-2
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04388  TGFBR2; TGF-beta receptor type-2
   05161 Hepatitis B
    K04388  TGFBR2; TGF-beta receptor type-2
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K04388  TGFBR2; TGF-beta receptor type-2
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K04388  TGFBR2; TGF-beta receptor type-2
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04388  TGFBR2; TGF-beta receptor type-2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04388  TGFBR2; TGF-beta receptor type-2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.30  receptor protein serine/threonine kinase
     K04388  TGFBR2; TGF-beta receptor type-2
Protein kinases [BR:ko01001]
 Receptor serine/threonine kinases (RSTK): TKL group
  TGFBR2 family [OT]
   K04388  TGFBR2; TGF-beta receptor type-2
Other DBs
GO: 0005026
Genes
HSA: 7048(TGFBR2)
PTR: 460243(TGFBR2)
PPS: 100985497(TGFBR2)
GGO: 101146131(TGFBR2)
PON: 100459236(TGFBR2)
NLE: 100606849(TGFBR2)
HMH: 116473711(TGFBR2)
MCC: 114675335 703088(TGFBR2)
MCF: 102134273(TGFBR2)
MTHB: 126946646
MNI: 105470963(TGFBR2)
CSAB: 103241808(TGFBR2)
CATY: 105578253(TGFBR2)
PANU: 101023107(TGFBR2)
TGE: 112618545(TGFBR2)
MLEU: 105543507(TGFBR2)
RRO: 104655082(TGFBR2)
RBB: 108516558(TGFBR2)
TFN: 117084287(TGFBR2)
PTEH: 111526524(TGFBR2)
CANG: 105525773(TGFBR2)
CJC: 100404359(TGFBR2)
SBQ: 101034142(TGFBR2)
CIMI: 108299396(TGFBR2)
CSYR: 103261716(TGFBR2)
MMUR: 105883482(TGFBR2)
LCAT: 123627989(TGFBR2)
PCOQ: 105810553(TGFBR2)
OGA: 100960821(TGFBR2)
MMU: 21813(Tgfbr2)
MCAL: 110301725(Tgfbr2)
MPAH: 110327573(Tgfbr2)
RNO: 81810(Tgfbr2)
MCOC: 116073579(Tgfbr2)
ANU: 117693333(Tgfbr2)
MUN: 110547249(Tgfbr2)
CGE: 100773953(Tgfbr2)
MAUA: 101841725(Tgfbr2)
PROB: 127234956(Tgfbr2)
PLEU: 114704977(Tgfbr2)
MORG: 121464335(Tgfbr2)
MFOT: 126491130
AAMP: 119810460(Tgfbr2)
NGI: 103744639(Tgfbr2)
HGL: 101704397(Tgfbr2)
CPOC: 100718284(Tgfbr2)
CCAN: 109681522(Tgfbr2)
DORD: 105994860(Tgfbr2)
DSP: 122096026(Tgfbr2)
NCAR: 124968435
OCU: 100344335(TGFBR2)
OPI: 101534968(TGFBR2)
TUP: 102486518(TGFBR2)
GVR: 103591905(TGFBR2)
CFA: 477039(TGFBR2)
CLUD: 112668662(TGFBR2)
VVP: 112921591(TGFBR2)
VLG: 121478523(TGFBR2)
AML: 100482939(TGFBR2)
UMR: 103682015(TGFBR2)
UAH: 113253847(TGFBR2)
UAR: 123777686(TGFBR2)
ELK: 111158999
LLV: 125105441
MPUF: 101679858(TGFBR2)
NVS: 122909050(TGFBR2)
ORO: 101364575(TGFBR2)
EJU: 114212271(TGFBR2)
ZCA: 113916407(TGFBR2)
MLX: 118002661(TGFBR2)
NSU: 110570864(TGFBR2)
LWW: 102740086(TGFBR2)
FCA: 101091725(TGFBR2)
PYU: 121033562(TGFBR2)
PCOO: 112850049(TGFBR2)
PBG: 122492079(TGFBR2)
LRUF: 124526598
PTG: 102958413(TGFBR2)
PPAD: 109251365(TGFBR2)
PUC: 125921386
AJU: 106984570(TGFBR2)
HHV: 120224680(TGFBR2)
BTA: 535376(TGFBR2)
BOM: 102267018(TGFBR2)
BIU: 109576148(TGFBR2)
BBUB: 102415303(TGFBR2)
BBIS: 104985407(TGFBR2)
CHX: 100861300(TGFBR2)
OAS: 494191(TGFBR2)
ODA: 120867879(TGFBR2)
CCAD: 122424266(TGFBR2)
SSC: 100038019(TGFBR2)
CFR: 102509744(TGFBR2)
CBAI: 105072636(TGFBR2)
CDK: 105087202(TGFBR2)
VPC: 102529547(TGFBR2)
BACU: 103005777(TGFBR2)
LVE: 103077265(TGFBR2)
OOR: 101289351(TGFBR2)
DLE: 111164342(TGFBR2)
PCAD: 102995949(TGFBR2)
PSIU: 116761798(TGFBR2)
NASI: 112398737(TGFBR2)
ECB: 100033860(TGFBR2)
EPZ: 103567708(TGFBR2)
EAI: 106830994(TGFBR2)
MYB: 102248472(TGFBR2)
MYD: 102767756(TGFBR2)
MMYO: 118668257(TGFBR2)
MLF: 102434274(TGFBR2)
MNA: 107526381(TGFBR2)
PKL: 118715431(TGFBR2)
HAI: 109394441(TGFBR2)
DRO: 112309970(TGFBR2)
SHON: 119004086(TGFBR2)
AJM: 119039725(TGFBR2)
PDIC: 114501577(TGFBR2)
PHAS: 123830471(TGFBR2)
MMF: 118633307(TGFBR2)
RFQ: 117036921(TGFBR2)
PALE: 102889618(TGFBR2)
PGIG: 120586804(TGFBR2)
PVP: 105292451(TGFBR2)
RAY: 107508791(TGFBR2)
MJV: 108391859(TGFBR2)
TOD: 119257560(TGFBR2)
SARA: 101553495(TGFBR2)
LAV: 100671392(TGFBR2)
TMU: 101354258
ETF: 101660774(TGFBR2)
DNM: 101430016(TGFBR2)
MDO: 100031897(TGFBR2)
GAS: 123249688(TGFBR2)
SHR: 100913352(TGFBR2)
AFZ: 127538005
PCW: 110212998(TGFBR2)
OAA: 100076965(TGFBR2)
GGA: 396399(TGFBR2) 424261(AMHR2)
PCOC: 116227122(TGFBR2) 116227394
MGP: 100546861(TGFBR2) 100549829
CJO: 107309296(TGFBR2) 107316805
NMEL: 110393465(TGFBR2) 110399236
APLA: 101794795(TGFBR2) 101801641
ACYG: 106029911 106043323(TGFBR2)
AFUL: 116486426(TGFBR2) 116490458
TGU: 100220619(TGFBR2) 100224677
LSR: 110468201(TGFBR2) 110468281
SCAN: 103813156(TGFBR2) 103814641
PMOA: 120498661 120501746(TGFBR2)
OTC: 121337638(TGFBR2) 121338419
PRUF: 121353051(TGFBR2) 121356695
GFR: 102040558(TGFBR2) 102044945
FAB: 101808986 101811048(TGFBR2)
PHI: 102099204 102112281(TGFBR2)
PMAJ: 107200593(TGFBR2) 107207553
CCAE: 111923501(TGFBR2) 111932269
CCW: 104689295(TGFBR2) 104694032
CBRC: 103614150(TGFBR2) 103619725
ETL: 114064578(TGFBR2) 114067323
ZAB: 102071453(TGFBR2) 102074010
ACHL: 103805135 103811946(TGFBR2)
SVG: 106850468 106857782(TGFBR2)
FPG: 101911268(TGFBR2) 101924328
FCH: 102048632 102053489(TGFBR2)
CLV: 102083591(TGFBR2) 102091992
EGZ: 104122957(TGFBR2) 104128099
NNI: 104013882(TGFBR2) 104020241
PLET: 104617793 104621568
PCRI: 104025926(TGFBR2) 104037046
PCAO: 104042866(TGFBR2) 104043241
ACUN: 113477102(TGFBR2) 113482298
TALA: 104361811(TGFBR2) 104365779
PADL: 103917105(TGFBR2) 103919595
AFOR: 103906690(TGFBR2) 103908596
ACHC: 115339536(TGFBR2) 115342465
HALD: 104318414(TGFBR2)
HLE: 104833361 104842182(TGFBR2)
AGEN: 126037839 126044671
GCL: 127012761 127018314
CCRI: 104158018(TGFBR2) 104163511
CSTI: 104553607(TGFBR2)
EHS: 104509912(TGFBR2) 104514603
CMAC: 104477160(TGFBR2) 104478544
MUI: 104538496 104545180(TGFBR2)
FGA: 104083132 104083682
GSTE: 104257506(TGFBR2) 104260041
LDI: 104349047(TGFBR2) 104349491
MNB: 103768986 103772628(TGFBR2)
OHA: 104332631(TGFBR2) 104338219
NNT: 104404513 104409828
SHAB: 115608202 115613871(TGFBR2)
DPUB: 104298273(TGFBR2) 104303745
PGUU: 104459907(TGFBR2) 104471768
ACAR: 104524541(TGFBR2) 104529630
CPEA: 104387443 104397620(TGFBR2)
AVIT: 104277934 104281295(TGFBR2)
CVF: 104283917(TGFBR2) 104288491
CUCA: 104067611(TGFBR2) 104068637
TEO: 104384025
BRHI: 104489806 104501798(TGFBR2)
AAM: 106491249(TGFBR2) 106498480
AROW: 112965329(TGFBR2) 112976316
NPD: 112952606(TGFBR2) 112954963
TGT: 104564504 104570684(TGFBR2)
DNE: 112982398(TGFBR2) 112988508
SCAM: 104145645 104152532(TGFBR2)
ASN: 102371879 102380434(TGFBR2)
AMJ: 102567839(TGFBR2) 102573702
CPOO: 109310907(TGFBR2) 109322762
GGN: 109291697(TGFBR2) 109301398
PSS: 102444710(TGFBR2) 102457599
CMY: 102946534 102947040(TGFBR2)
CPIC: 101930851 101936050(TGFBR2)
TST: 117872410(TGFBR2) 117885102
CABI: 116827024(TGFBR2) 116832884
MRV: 120375044 120398476(TGFBR2)
ACS: 100552899(tgfbr2) 100556560
PVT: 110086832(TGFBR2) 110090113
SUND: 121934614(TGFBR2)
PBI: 103057562(TGFBR2) 103063579
PMUR: 107284378(TGFBR2) 107290268
CTIG: 120299217 120308137(TGFBR2)
TSR: 106543204 106547952(TGFBR2)
PGUT: 117656107(TGFBR2) 117674410
VKO: 123016834(TGFBR2) 123027347
PMUA: 114604090 114607243(TGFBR2)
ZVI: 118091951 118092373(TGFBR2)
HCG: 128323669 128330376(TGFBR2)
GJA: 107125145 107125583
STOW: 125426866 125440929(TGFBR2)
XLA: 108702885(tgfbr2l.S) 108718935(tgfbr2.L) 108719963(tgfbr2.S) 373815(tgfbr2l.L)
XTR: 100487430(tgfbr2.2) 100488582(tgfbr2)
NPR: 108792234 108803008
RTEM: 120940316(TGFBR2)
BBUF: 121002016(TGFBR2)
BGAR: 122938407(TGFBR2)
DRE: 30739(tgfbr2b) 560446(si:dkey-101k6.5)
SRX: 107713826 107714146 107714281 107730143 107733061 107741917
SANH: 107660622 107665091 107666835(tgfbr2) 107668281 107673748 107703987
SGH: 107551196 107555932 107569139 107596078 107600517
CCAR: 109088721 109096024 109106189(tgfbr2) 109111096
CAUA: 113053042 113059227 113059311 113062545 113062562 113108385 113115942 113119703
CGIB: 127964812 127974979 128020028 128030465
PPRM: 120461610(tgfbr2l) 120462277(tgfbr2b)
MAMB: 125243030(tgfbr2b) 125270567(tgfbr2l)
CIDE: 127497383 127519363
MASI: 127447217 127448498 127453460 127454485
IPU: 108266333(tgfbr2l) 108270231(tgfbr2b) 108274807(tgfbr2a)
PHYP: 113523903 113526523(tgfbr2) 113546836
SMEO: 124383254(tgfbr2l) 124384386(tgfbr2b) 124392955
TFD: 113644505(tgfbr2b) 113648975 113654227(tgfbr2l)
AMEX: 103031725(tgfbr2) 103042559 103047038
EEE: 113583131(tgfbr2) 113590604 113591515 113591517
TRU: 101061688 101061957 101064978
TNG: GSTEN00012314G001 GSTEN00025846G001 GSTEN00035878G001
LCO: 104922506(tgfbr2) 104923102
NCC: 104941004 104949722 104964880(tgfbr2)
CGOB: 115005781 115005886 115015457(tgfbr2)
ELY: 117251018(tgfbr2l) 117264185 117266445
EFO: 125892854 125899788(tgfbr2l) 125904247
PLEP: 121945114 121948665 121957662
SLUC: 116046615(tgfbr2l) 116047287 116066638(tgfbr2b)
ECRA: 117939789 117946465 117956907
ESP: 116686746 116701720
PFLV: 114556613 114563526 114568194(tgfbr2)
GAT: 120810689(tgfbr2b) 120826425 120833504(tgfbr2l)
PPUG: 119197680(tgfbr2b) 119219642 119229310
MSAM: 119898112(tgfbr2b) 119903766(tgfbr2l) 119907257
CUD: 121513411(tgfbr2b) 121522309(tgfbr2l) 121523898
ALAT: 119006792 119017058 119025558(tgfbr2l)
MZE: 101465777 101478446 101479131 112430746 112435557
ONL: 100692823 100712573(tgfbr2b) 106098551(tgfbr2l)
OAU: 116312139(tgfbr2b) 116312450(tgfbr2l) 116319415
OLA: 101170689(tgfbr2) 101174785
OML: 112155588(tgfbr2l) 112162680(tgfbr2b)
XMA: 102218164 102231514
XCO: 114145015 114156140
XHE: 116717534 116731491
PRET: 103465886(tgfbr2) 103472661
PFOR: 103136959 103144447(tgfbr2)
PLAI: 106954227 106960810
PMEI: 106915864(tgfbr2) 106917549
GAF: 122831193(tgfbr2b) 122843422
CVG: 107086189(tgfbr2) 107098322
CTUL: 119778004 119790175
GMU: 124865875(tgfbr2b) 124871723(tgfbr2l) 124879943
NFU: 107372384 107389601 107394548
KMR: 108237979 108247742(tgfbr2b) 108247801(tgfbr2l)
ALIM: 106519273 106520852 106525496
NWH: 119410412 119419339(tgfbr2l) 119425817
AOCE: 111564865 111568072 111569697 111573752
MCEP: 125016388 125017218(tgfbr2l) 125020371
CSEM: 103388716 103391513 103394297
POV: 109631953 109639132 109647461
SSEN: 122764845(tgfbr2l) 122775221 122786700
HHIP: 117754491(tgfbr2l) 117770903 117777178
HSP: 118113748 118119939(tgfbr2l) 118124881
LCF: 108876301 108881978 108889085
SDU: 111223506 111225824 111237959
SLAL: 111644571 111657623 111664183
XGL: 120784290 120786336 120802043
HCQ: 109516370(tgfbr2) 109530278
SSCV: 125973820 125987180
BPEC: 110162936 110167264 110171603
MALB: 109958786 109966655 109971941
BSPL: 114846902(tgfbr2l) 114865692
SASA: 100195227(tgfr2) 106586454 106588201 106606173
STRU: 115155646 115160989 115173307 115176037
OTW: 112225563 112229968 112239013(tgfbr2l) 112239812 112241489 112264984 121843252
OMY: 101268944(tgfr2) 110496033 110501778 110518401(tgfbr2b) 110520304(tgfbr2l)
OGO: 124013252 124020749 124028313 124043662 124044023(tgfbr2l) 124047140
ONE: 115111341 115128230 115129607 115131753
SALP: 111955151 111956220 111977561 112070624
SNH: 120022652 120027347 120057931(tgfbr2l) 120063757
CCLU: 121536986 121542581 121555017 121556728 121571445 121586338
ELS: 105012782 105014569 105023521(tgfbr2) 105030836
SFM: 108918826 108935840(tgfbr2)
PKI: 111857200 111857846(tgfbr2)
AANG: 118207140(tgfbr2b) 118214501(tgfbr2l) 118233779
LOC: 102682723(tgfbr2) 102692092
PSPA: 121312913(tgfbr2b) 121314717 121322376(tgfbr2l) 121322837
ARUT: 117394619 117400383 117426292
PSEX: 120515765(tgfbr2b) 120530780(tgfbr2l)
LCM: 102346621(TGFBR2) 102356233
CMK: 103176334(tgfbr2b) 103188937(tgfbr2l)
RTP: 109916891 109926924
CPLA: 122551670(tgfbr2l) 122564406(tgfbr2b)
BFO: 118403077
BBEL: 109475792
CIN: 778778(tgfbr-iib)
SCLV: 120343230
SPU: 580712
APLC: 110984215
SKO: 100329004(TGFbRII)
EPA: 110254510
ATEN: 116295466
 » show all
Reference
PMID:1310899
  Authors
Lin HY, Wang XF, Ng-Eaton E, Weinberg RA, Lodish HF
  Title
Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase.
  Journal
Cell 68:775-85 (1992)
DOI:10.1016/0092-8674(92)90152-3
  Sequence
[hsa:7048]

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Ontology (4)   
   KEGG BRITE (3)   
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Pathway (46)   
   KEGG PATHWAY (46)   
Disease (6)   
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Drug (1)   
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Chemical reaction (1)   
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Gene (974)   
   KEGG GENES (620)   
   KEGG MGENES (103)   
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