KEGG   ORTHOLOGY: K04389
Entry
K04389                      KO                                     
Symbol
TNFSF6, FASL, CD178
Name
tumor necrosis factor ligand superfamily member 6
Pathway
map01524  Platinum drug resistance
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04060  Cytokine-cytokine receptor interaction
map04068  FoxO signaling pathway
map04151  PI3K-Akt signaling pathway
map04210  Apoptosis
map04217  Necroptosis
map04650  Natural killer cell mediated cytotoxicity
map04722  Neurotrophin signaling pathway
map04932  Non-alcoholic fatty liver disease
map04936  Alcoholic liver disease
map04940  Type I diabetes mellitus
map05022  Pathways of neurodegeneration - multiple diseases
map05130  Pathogenic Escherichia coli infection
map05142  Chagas disease
map05143  African trypanosomiasis
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05165  Human papillomavirus infection
map05168  Herpes simplex virus 1 infection
map05170  Human immunodeficiency virus 1 infection
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05320  Autoimmune thyroid disease
map05330  Allograft rejection
map05332  Graft-versus-host disease
map05417  Lipid and atherosclerosis
Disease
H00108  Autoimmune lymphoproliferative syndromes
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   04014 Ras signaling pathway
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   04068 FoxO signaling pathway
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   04151 PI3K-Akt signaling pathway
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   04217 Necroptosis
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05205 Proteoglycans in cancer
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05161 Hepatitis B
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05160 Hepatitis C
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05164 Influenza A
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05162 Measles
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05168 Herpes simplex virus 1 infection
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05163 Human cytomegalovirus infection
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05165 Human papillomavirus infection
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05143 African trypanosomiasis
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09163 Immune disease
   05320 Autoimmune thyroid disease
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05330 Allograft rejection
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05332 Graft-versus-host disease
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09164 Neurodegenerative disease
   05022 Pathways of neurodegeneration - multiple diseases
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   04936 Alcoholic liver disease
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   04932 Non-alcoholic fatty liver disease
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   04052 Cytokines and neuropeptides
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   04090 CD molecules
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
Cytokines and neuropeptides [BR:ko04052]
 Cytokines
  Tumor necrosis fators
   K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
CD molecules [BR:ko04090]
 Proteins
  K04389  CD178, FASLG; tumor necrosis factor (ligand) superfamily, member 6
Other DBs
GO: 0005164
Genes
HSA: 356(FASLG)
PTR: 469584(FASLG)
PPS: 100970360(FASLG)
GGO: 101137781(FASLG)
PON: 100461418(FASLG)
PPYG: 129012290(FASLG)
NLE: 100597719(FASLG)
HMH: 116472296(FASLG)
SSYN: 134734793(FASLG)
MCC: 574159(FASLG)
MCF: 102139406(FASLG)
MTHB: 126941397
MNI: 105484428(FASLG)
CSAB: 103230577(FASLG)
CATY: 105597557(FASLG)
PANU: 101000210(FASLG)
TGE: 112636918(FASLG)
MLEU: 105554126(FASLG)
RRO: 104669600(FASLG)
RBB: 108526259(FASLG)
TFN: 117074605(FASLG)
PTEH: 111539343(FASLG)
CANG: 105526354(FASLG)
CJC: 100404850(FASLG)
SBQ: 101035660(FASLG)
CIMI: 108305379 108305380(FASLG)
ANAN: 105711795(FASLG)
CSYR: 103273211(FASLG)
MMUR: 105871667(FASLG)
LCAT: 123634668(FASLG)
PCOQ: 105821114(FASLG)
OGA: 100951008(FASLG)
MMU: 14103(Fasl)
MCAL: 110300709(Faslg)
MPAH: 110322215(Faslg)
RNO: 25385(Faslg)
MCOC: 116070785(Faslg)
ANU: 117716367(Faslg)
MUN: 110556827(Faslg)
CGE: 100773293(Faslg)
MAUA: 101843397(Faslg)
PROB: 127223236(Faslg)
PLEU: 114689971(Faslg)
MORG: 121455415(Faslg)
MFOT: 126511310
AAMP: 119827881(Faslg)
NGI: 103740694(Faslg)
HGL: 101698642(Faslg)
CPOC: 100714139(Faslg)
CCAN: 109689125(Faslg)
DORD: 105985196(Faslg)
DSP: 122103807(Faslg)
PLOP: 125360260(Faslg)
NCAR: 124962014
MMMA: 107147374(Faslg)
OCU: 100344073
OPI: 101528266(FASLG)
TUP: 102502878(FASLG)
GVR: 103605950(FASLG)
CFA: 442968(FASLG)
CLUD: 112648603(FASLG)
VVP: 112921762(FASLG)
VLG: 121498932(FASLG)
NPO: 129506047(FASLG)
AML: 100468235(FASLG)
UMR: 103668115(FASLG)
UAH: 113262825(FASLG)
UAR: 123803052(FASLG)
ELK: 111150819 111150909
LLV: 125086282
MPUF: 101687517(FASLG)
MNP: 132026045(FASLG)
MLK: 131814928(FASLG)
NVS: 122918121(FASLG)
ORO: 101381319(FASLG)
EJU: 114223997(FASLG)
ZCA: 113931754(FASLG)
MLX: 118014469(FASLG)
NSU: 110574012(FASLG)
LWW: 102745146
FCA: 493945(FASLG)
PYU: 121015025(FASLG)
PCOO: 112863203(FASLG)
PBG: 122476073(FASLG)
PVIV: 125154937(FASLG)
LRUF: 124510216
PTG: 102953222(FASLG)
PPAD: 109252525(FASLG)
PUC: 125925158
AJU: 106979842
HHV: 120224200(FASLG)
BTA: 407111(FASLG)
BOM: 102281889(FASLG)
BIU: 109570480 109570785(FASLG)
BBUB: 102404535(FASLG)
BBIS: 104995820(FASLG)
CHX: 102178753(FASLG)
OAS: 100135696(FASLG)
BTAX: 128061812(FASLG)
ODA: 120880243(FASLG)
CCAD: 122452409(FASLG)
MBEZ: 129551094(FASLG)
SSC: 396726(FASLG)
CFR: 102503604(FASLG)
CBAI: 105070302(FASLG)
CDK: 105092770(FASLG)
VPC: 102536116(FASLG)
BACU: 102999836(FASLG)
BMUS: 118906923(FASLG)
LVE: 103073066(FASLG)
OOR: 101272436(FASLG)
DLE: 111170265(FASLG)
PCAD: 102979864(FASLG)
PSIU: 116739025(FASLG)
NASI: 112391613(FASLG)
ECB: 100052326(FASLG)
EPZ: 103554252(FASLG)
EAI: 106838669(FASLG)
MYB: 102262076(FASLG)
MYD: 102759597(FASLG)
MMYO: 118673639(FASLG)
MLF: 102439228(FASLG)
MDT: 132220415(FASLG)
PKL: 118721567(FASLG)
EFUS: 103289966(FASLG)
MNA: 107543787(FASLG)
DRO: 112297049(FASLG)
SHON: 118979183(FASLG)
AJM: 119065454(FASLG)
PDIC: 114512032(FASLG)
PHAS: 123818449(FASLG)
MMF: 118637768(FASLG)
PPAM: 129081899(FASLG)
HAI: 109385146(FASLG)
RFQ: 117014309(FASLG)
PALE: 102883204(FASLG)
PGIG: 120617668(FASLG)
PVP: 105299797(FASLG)
RAY: 107512052(FASLG)
MJV: 108401438(FASLG)
TOD: 119240071(FASLG)
LAV: 100662586(FASLG)
TMU: 101344408
DNM: 101417353(FASLG)
GAS: 123245896(FASLG)
SHR: 100919776(FASLG)
AFZ: 127562897
PCW: 110197002(FASLG)
TVP: 118848364(FASLG)
OAA: 100081646(FASLG)
GGA: 429064(FASLG)
PCOC: 116230501(FASLG)
MGP: 100551315(FASLG)
TPAI: 128072661(FASLG)
LMUT: 125693084(FASLG)
NMEL: 110402693(FASLG)
APLA: 101801884(FASLG)
ACYG: 106041569(FASLG)
CATA: 118243636(FASLG)
AFUL: 116491691(FASLG)
TGU: 100230435(FASLG)
LSR: 110478980(FASLG)
SCAN: 103823387(FASLG)
PMOA: 120512233(FASLG)
OTC: 121344224(FASLG)
PRUF: 121359744(FASLG)
GFR: 102045588(FASLG)
FAB: 101820749(FASLG)
OMA: 130256177(FASLG)
PHI: 102107854(FASLG)
PMAJ: 107207877(FASLG)
CCAE: 111932669(FASLG)
CCW: 104695445(FASLG)
CBRC: 103612526(FASLG)
ETL: 114063951(FASLG)
ZAB: 102065064(FASLG)
ZLE: 135451174(FASLG)
ACHL: 103803923(FASLG)
SVG: 106852213(FASLG)
MMEA: 130577415(FASLG)
HRT: 120756701(FASLG)
SATI: 136365216(FASLG)
FPG: 101922036(FASLG)
FCH: 102046752(FASLG)
CCRI: 104161769(FASLG)
NNT: 104406980 104407830(FASLG)
SHAB: 115612049(FASLG)
ACUN: 113483045(FASLG)
TALA: 104363277(FASLG)
ACHC: 115349144(FASLG)
HALD: 104323772(FASLG)
HLE: 104840355(FASLG)
AGEN: 126042346
GCL: 127019368
CSTI: 104564107(FASLG)
LDI: 104346858(FASLG)
MNB: 103770510(FASLG)
DPUB: 104298200(FASLG)
AVIT: 104268369(FASLG)
BRHI: 104491291(FASLG)
EGZ: 104132069(FASLG)
NNI: 104010400(FASLG)
PCRI: 104034680(FASLG)
PCAO: 104051447(FASLG)
PADL: 103914004(FASLG)
AFOR: 103894000(FASLG)
FGA: 104070358(FASLG)
GSTE: 104262491(FASLG)
CLV: 102097854(FASLG)
MUI: 104548943(FASLG)
PGUU: 104466139(FASLG)
PLET: 104618161(FASLG)
EHS: 104511975
CMAC: 104477426(FASLG)
CUCA: 104058367(FASLG)
TEO: 104381056(FASLG)
BREG: 104634122(FASLG)
OHA: 104333720(FASLG)
ACAR: 104527774(FASLG)
CPEA: 104390683(FASLG)
CVF: 104293321(FASLG)
RTD: 128913335(FASLG)
AAM: 106499698(FASLG)
AROW: 112977130(FASLG)
NPD: 112951177(FASLG)
TGT: 104574931(FASLG)
DNE: 112997421(FASLG)
SCAM: 104142697(FASLG)
AMJ: 102564044(FASLG)
CPOO: 109306951(FASLG)
GGN: 109305351(FASLG)
PSS: 102460695(FASLG)
CMY: 102937724(FASLG)
CCAY: 125641749(FASLG)
DCC: 119860555(FASLG)
CPIC: 101951265(FASLG)
TST: 117882288(FASLG)
CABI: 116822232(FASLG)
MRV: 120370739(FASLG)
ACS: 100554702(faslg)
ASAO: 132772749(FASLG)
PVT: 110089831(FASLG)
SUND: 121927998(FASLG)
PBI: 103051809
PMUR: 107290564(FASLG)
CTIG: 120300257(FASLG)
TSR: 106553443
PGUT: 117661286(FASLG)
APRI: 131194640(FASLG)
PTEX: 113438172(FASLG)
NSS: 113421451(FASLG)
VKO: 123028014(FASLG)
PMUA: 114598486(FASLG)
PRAF: 128415181(FASLG)
ZVI: 118078298(FASLG)
HCG: 128323970(FASLG)
GJA: 107115985
STOW: 125433295(FASLG)
EMC: 129331288(FASLG)
XLA: 100192357(faslg.L) 108715004(faslg.S)
XTR: 100124789(faslg)
NPR: 108795559(FASLG)
RTEM: 120930928 120944854(FASLG)
BBUF: 120978943(FASLG)
BGAR: 122943681(FASLG)
MUO: 115473278(FASLG)
GSH: 117368487(FASLG) 117368572
DRE: 735295(faslg)
SRX: 107712839 107739860
SANH: 107658160 107669138
SGH: 107581522 107597819
CCAR: 109064022 109113842
CAUA: 113062743 113121150
CGIB: 127938706
PTET: 122324582(faslg)
LROH: 127183201(faslg)
OMC: 131527369(faslg)
PPRM: 120493499(faslg)
RKG: 130096107(faslg)
MAMB: 125279072(faslg)
CIDE: 127502691
CERY: 137018740(faslg)
MASI: 127410404 127416109
TROS: 130565749(faslg)
TDW: 130434609(faslg)
MANU: 129430073(faslg)
IPU: 108257517
IFU: 128601264(faslg)
PHYP: 113545312(faslg)
SMEO: 124377174(faslg)
TFD: 113658725(faslg)
TVC: 132842360(faslg)
TRN: 134320004(faslg)
AMEX: 103027441(faslg)
CMAO: 118816146(faslg)
EEE: 113589104
CHAR: 122131951(faslg)
TRU: 101068020 101074300
TFS: 130529165(faslg) 130530910(cd40lg)
LCO: 104917990 104926008
NCC: 104957984 104964064(faslg)
TBEN: 117487826(cd40lg) 117495771(faslg)
CGOB: 115007592(faslg) 115014829
PGEO: 117445724(faslg) 117454183(cd40lg)
GACU: 117537588(cd40lg) 117555215(faslg)
EMAC: 134859581(cd40lg) 134869225(faslg)
ELY: 117253399(faslg) 117261369(cd40lg)
EFO: 125894361(cd40lg) 125895955(faslg)
PLEP: 121948288(cd40lg) 121965450(faslg)
SLUC: 116052328(cd40lg) 116058891(faslg)
ECRA: 117949987(faslg) 117951831(cd40lg)
ESP: 116695203 116697062
PFLV: 114563150
GAT: 120816898(cd40lg) 120823431(faslg)
PPUG: 119210096(cd40lg) 119217173(faslg)
AFB: 129090345(cd40lg) 129094969(faslg) 129110212
CLUM: 117729612(faslg) 117737089(cd40lg)
PSWI: 130194492(faslg) 130209868(cd40lg)
MSAM: 119888531(cd40lg) 119901000(faslg)
SCHU: 122878277(faslg) 122879886(cd40lg)
CUD: 121511949(faslg) 121516645(cd40lg)
ALAT: 119007260(cd40lg) 119029123(faslg)
MZE: 101467059 101473046
ONL: 100703882(cd40lg) 100705827
OAU: 116317586(cd40lg) 116331186(faslg)
OLA: 101159737 101167049
OML: 112150637 112153304(cd40lg)
CSAI: 133447624(cd40lg) 133457734(faslg)
XMA: 102222747 102224562
XCO: 114139005 114150361(faslg)
XHE: 116714046 116725172
PRET: 103463758 103471589
PFOR: 103137043(faslg) 103140155
PLAI: 106945746 106947717
PMEI: 106916375 106920845
GAF: 122837358(cd40lg) 122839075(faslg)
PPRL: 129360331 129360357 129376319(faslg)
CVG: 107089263 107095892
CTUL: 119786254(cd40lg) 119799270(faslg)
GMU: 124860047(cd40lg) 124874253(faslg)
NFU: 107378854 107396466
KMR: 108230718(faslg) 108231281(cd40lg)
ALIM: 106512210
NWH: 119408006(faslg) 119429542(cd40lg)
AOCE: 111566322 111573689 111577528
MCEP: 125007881(cd40lg) 125009173(faslg)
CSEM: 103376745 103390777
POV: 109625570
SSEN: 122762115(faslg) 122778162(cd40lg)
HHIP: 117760140(faslg) 117769667(cd40lg)
HSP: 118111865(cd40lg) 118121152(faslg)
PPLT: 128445502(cd40lg) 128448629(faslg)
SMAU: 118317959(faslg) 118319019(cd40lg)
LCF: 108872556(cd40lg) 108879004(faslg)
SDU: 111232053 111232361
SLAL: 111666336 111671959
XGL: 120785458(cd40lg) 120790939(faslg)
HCQ: 109509036 109511350 109511934 109531905(faslg)
SSCV: 125976228 125993809
SBIA: 133503995(faslg) 133507045 133507046 133509029
PEE: 133406663(faslg) 133408162(cd40lg) 133408478
PTAO: 133483714(faslg) 133484977(cd40lg)
BPEC: 110154839(faslg) 110158999
MALB: 109952425 109955330
BSPL: 114854739(faslg) 114864428(cd40lg)
SJO: 128362426(faslg) 128363160(cd40lg)
SASA: 100196289(tnfl6) 106579980 106613961
STRU: 115158458 115192444
OTW: 112248671 112251074 112263074
OMY: 110521615 110524498(faslg) 110525015
OGO: 123994201 123998033(faslg) 124011387 124019398
ONE: 115107419 115129399 115131153 115145481
OKI: 109864457 109897503 109901577 109906007
OKE: 118358720 118372136 118376928 118391875
SALP: 111957671 111972008 111976015
SNH: 120046999 120051847(faslg) 120054895 120062108
CCLU: 121533348(faslg) 121539881
ELS: 105011736(faslg) 105014159
SFM: 108923469 114911301
PKI: 111834820
AANG: 118224955(faslg)
LOC: 102682852(faslg)
PSPA: 121326429(faslg) 121330683
ARUT: 117411359(faslg)
LCM: 102361141 102366280(FASLG)
CMK: 103180013 103180014 103180016
RTP: 109930946 109930950 109930951
CPLA: 122554602 122554794 122554795
HOC: 132818661 132818663 132818664(faslg)
LERI: 129701294 129701295 129715694
LRJ: 133360214 133360216
BBEL: 109472475
SPU: 105444300 115922386
LGI: LOTGIDRAFT_171624
PVUL: 130010364
BGT: 106055696 106063191 106069033
HRF: 124122930 124122943 124124804 124125172 124125181 124125182 124125185 124125187 124125200
HRJ: 124274908 124282362 124282365 124282367 124282368 124282373
CRG: 105330636 105346253
CANU: 128181208
MYI: 110463627
PMAX: 117342302 117342975
MMER: 123554550 123554562 123554710 123555531
DPOL: 127834938
DGT: 114535707
 » show all
Reference
PMID:7528780
  Authors
Alderson MR, Tough TW, Davis-Smith T, Braddy S, Falk B, Schooley KA, Goodwin RG, Smith CA, Ramsdell F, Lynch DH
  Title
Fas ligand mediates activation-induced cell death in human T lymphocytes.
  Journal
J Exp Med 181:71-7 (1995)
DOI:10.1084/jem.181.1.71
  Sequence
[hsa:356]
Reference
PMID:17557115
  Authors
Kirkin V, Cahuzac N, Guardiola-Serrano F, Huault S, Luckerath K, Friedmann E, Novac N, Wels WS, Martoglio B, Hueber AO, Zornig M
  Title
The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells.
  Journal
Cell Death Differ 14:1678-87 (2007)
DOI:10.1038/sj.cdd.4402175
  Sequence
[hsa:356]
Reference
PMID:7826947
  Authors
Takahashi T, Tanaka M, Inazawa J, Abe T, Suda T, Nagata S
  Title
Human Fas ligand: gene structure, chromosomal location and species specificity.
  Journal
Int Immunol 6:1567-74 (1994)
DOI:10.1093/intimm/6.10.1567
  Sequence
[hsa:356]

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