KEGG ORTHOLOGY: K04404

ORTHOLOGY: K04404

Entry

K04404                      KO

Symbol

MAP3K7IP2, TAB2

Name

TAK1-binding protein 2

Pathway

map04010

MAPK signaling pathway

map04013

MAPK signaling pathway - fly

map04064

NF-kappa B signaling pathway

map04214

Apoptosis - fly

map04380

Osteoclast differentiation

map04620

Toll-like receptor signaling pathway

map04621

NOD-like receptor signaling pathway

map04624

Toll and Imd signaling pathway

map04657

IL-17 signaling pathway

map04668

TNF signaling pathway

map04936

Alcoholic liver disease

map05130

Pathogenic Escherichia coli infection

map05131

Shigellosis

map05132

Salmonella infection

map05135

Yersinia infection

map05140

Leishmaniasis

map05145

Toxoplasmosis

map05161

Hepatitis B

map05162

Measles

map05168

Herpes simplex virus 1 infection

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05171

Coronavirus disease - COVID-19

map05417

Lipid and atherosclerosis

Disease

H02199

Congenital heart defects, multiple type

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   04013 MAPK signaling pathway - fly
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   04064 NF-kappa B signaling pathway
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   04668 TNF signaling pathway
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
09140 Cellular Processes
  09143 Cell growth and death
   04214 Apoptosis - fly
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   04624 Toll and Imd signaling pathway
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   04621 NOD-like receptor signaling pathway
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   04657 IL-17 signaling pathway
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   05161 Hepatitis B
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   05171 Coronavirus disease - COVID-19
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   05162 Measles
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   05168 Herpes simplex virus 1 infection
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   05169 Epstein-Barr virus infection
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   05132 Salmonella infection
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   05131 Shigellosis
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   05135 Yersinia infection
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
   05140 Leishmaniasis
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2

Genes

HSA:	23118(TAB2)

PTR:	463057(TAB2)

PPS:	100992480(TAB2)

GGO:	101126531(TAB2)

PON:	100174071(TAB2)

PPYG:

129038270(TAB2)

NLE:	100597932(TAB2)

HMH:	116463159 116463202

SSYN:

129475068(TAB2)

MCC:	696875(TAB2)

MCF:	101865975(TAB2)

MTHB:

126952491

MNI:	105489001(TAB2)

CSAB:

103240159(TAB2)

CATY:

105588814(TAB2)

PANU:

100997900(TAB2)

TGE:	112622975(TAB2)

MLEU:

105528775(TAB2)

RRO:	104676257(TAB2) 115899261

RBB:	108536673(TAB2)

TFN:	117097302(TAB2)

PTEH:

111523666(TAB2)

CANG:

105515555(TAB2)

CJC:	100414129(TAB2)

SBQ:	101040230(TAB2)

CIMI:

108287389(TAB2)

ANAN:

105717345(TAB2)

CSYR:

103254079(TAB2)

MMUR:

105868645(TAB2)

LCAT:

123633357(TAB2)

PCOQ:

105819344(TAB2)

OGA:	100955970(TAB2)

MMU:	68652(Tab2)

MCAL:

110303600(Tab2)

MPAH:

110338176(Tab2)

RNO:	308267(Tab2)

MCOC:

116097745(Tab2)

ANU:	117700141(Tab2)

MUN:	110540621(Tab2)

CGE:	100759882(Tab2)

MAUA:

101844616(Tab2)

PROB:

127237647(Tab2)

PLEU:

114686371(Tab2)

MORG:

121466422(Tab2)

MFOT:

126513299

AAMP:

119820349(Tab2)

NGI:	103731917(Tab2)

HGL:	101698406(Tab2)

CPOC:

100717911(Tab2)

CCAN:

109692528(Tab2)

DORD:

105993663(Tab2)

DSP:	122102982(Tab2)

PLOP:

125357392(Tab2)

NCAR:

124988761

MMMA:

107156048(Tab2)

OCU:

100342249

OPI:	101517735(TAB2)

TUP:	102478674(TAB2)

GVR:	103593058(TAB2)

CFA:	484028(TAB2)

CLUD:

112644286(TAB2)

VVP:	112919509(TAB2)

VLG:	121482257(TAB2)

NPO:	129499952(TAB2)

AML:	100468085(TAB2)

UMR:	103666926(TAB2)

UAH:	113259542(TAB2)

UAR:	123797428(TAB2)

ELK:

111147521

LLV:

125101867

MPUF:

101690549(TAB2)

MNP:	132018229(TAB2)

MLK:	131833695(TAB2)

NVS:	122905565(TAB2)

ORO:	101369627(TAB2)

EJU:	114209197(TAB2)

ZCA:	113927705(TAB2)

MLX:	118001048(TAB2)

NSU:	110583336(TAB2)

LWW:	102732150(TAB2)

FCA:	101098714(TAB2)

PYU:	121013336(TAB2)

PCOO:

112862397(TAB2)

PBG:	122490077(TAB2)

PVIV:

125165360(TAB2)

LRUF:

124528760

PTG:	102959790(TAB2)

PPAD:

109252493(TAB2)

PUC:

125938017

AJU:

106987183

HHV:	120237570(TAB2)

BTA:	540203(TAB2)

BOM:	102278516(TAB2)

BIU:	109564026(TAB2)

BBUB:

102413796(TAB2)

BBIS:

105004816(TAB2)

CHX:	102187405(TAB2)

OAS:	101122114(TAB2)

BTAX:

128053126(TAB2)

ODA:	120862594(TAB2)

CCAD:

122433842(TAB2)

MBEZ:

129560692(TAB2)

SSC:	100156182(TAB2)

CFR:	102516031(TAB2)

CBAI:

105077308(TAB2)

CDK:	105100906(TAB2)

VPC:	102534039(TAB2)

BACU:

102997501(TAB2)

BMUS:

118905110(TAB2)

LVE:	103074334(TAB2)

OOR:	101284365(TAB2)

DLE:	111166813(TAB2)

PCAD:

102996495(TAB2)

PSIU:

116763460(TAB2)

NASI:

112401606(TAB2)

ECB:	100060433(TAB2)

EPZ:	103548723(TAB2)

EAI:	106837218(TAB2)

MYB:	102248925(TAB2)

MYD:	102770532(TAB2)

MMYO:

118659738(TAB2)

MLF:	102439412(TAB2)

MDT:	132236801(TAB2)

PKL:	118705059(TAB2)

EFUS:

103302357(TAB2)

MNA:	107545742(TAB2)

DRO:	112297111(TAB2)

SHON:

118978986(TAB2)

AJM:	119057909(TAB2)

PDIC:

114495234(TAB2)

PHAS:

123821688(TAB2)

MMF:	118620813(TAB2)

PPAM:

129067833(TAB2)

HAI:	109380888(TAB2)

RFQ:	117020204(TAB2)

PALE:

102898592(TAB2)

PGIG:

120589386(TAB2)

PVP:	105289440(TAB2)

RAY:	107518453(TAB2)

MJV:	108395672(TAB2)

TOD:	119252963(TAB2)

SARA:

101539336(TAB2)

SETR:

126031061(TAB2)

LAV:	100656450(TAB2)

TMU:

101355146

ETF:	101642439(TAB2)

DNM:	101447376(TAB2)

MDO:	100026855(TAB2)

GAS:	123243627(TAB2)

SHR:	100930713(TAB2)

AFZ:

127562312

PCW:	110208533(TAB2)

TVP:	118856682(TAB2)

OAA:	100074866(TAB2)

GGA:	421622(TAB2)

PCOC:

116241586(TAB2)

MGP:	100540789(TAB2)

CJO:	107311553(TAB2)

TPAI:

128079938(TAB2)

LMUT:

125689225(TAB2)

NMEL:

110395593(TAB2)

APLA:

101790309(TAB2)

ACYG:

106034268(TAB2)

CATA:

118244069(TAB2)

AFUL:

116487122(TAB2)

TGU:	100225126(TAB2)

LSR:	110468849(TAB2)

SCAN:

103818533(TAB2)

PMOA:

120501238(TAB2)

OTC:	121346041(TAB2)

PRUF:

121354820(TAB2)

GFR:	102037601(TAB2)

FAB:	101808905(TAB2)

OMA:	130250537(TAB2)

PHI:	102109164(TAB2)

PMAJ:

107202278(TAB2)

CCAE:

111926823(TAB2)

CCW:	104689165(TAB2)

CBRC:

103617060(TAB2)

ETL:	114059183(TAB2)

ZAB:	102062120(TAB2)

ZLE:	135445632(TAB2)

ACHL:

103804172(TAB2)

SVG:	106858498(TAB2)

MMEA:

130572351(TAB2)

HRT:	120750531(TAB2)

SATI:

136359217(TAB2)

FPG:	101920039(TAB2)

FCH:	102047715(TAB2)

CCRI:

104167306(TAB2)

NNT:	104402341(TAB2)

SHAB:

115614010(TAB2)

ACUN:

113478283(TAB2)

TALA:

104358632(TAB2)

ACHC:

115345137(TAB2)

HALD:

104325173(TAB2)

HLE:	104840741(TAB2)

AGEN:

126038499

GCL:

127014098

CSTI:

104561184(TAB2)

LDI:	104346900(TAB2)

MNB:	103780878(TAB2)

DPUB:

104297166(TAB2)

AVIT:

104276537(TAB2)

BRHI:

104496992(TAB2)

EGZ:	104133546(TAB2)

NNI:	104013777(TAB2)

PCRI:

104028690(TAB2)

PCAO:

104046505(TAB2)

PADL:

103917026(TAB2)

AFOR:

103900674(TAB2)

FGA:	104083593(TAB2)

GSTE:

104263509(TAB2)

CLV:	102092362(TAB2)

MUI:	104536892(TAB2)

PGUU:

104461660(TAB2)

PLET:

104624032(TAB2)

EHS:	104508000(TAB2)

CMAC:

104484103(TAB2)

CUCA:

104056809(TAB2)

TEO:	104382407(TAB2)

BREG:

104641813(TAB2)

OHA:	104328697(TAB2)

ACAR:

104530967(TAB2)

CPEA:

104390776(TAB2)

CVF:	104284909(TAB2)

RTD:	128906691(TAB2)

AAM:	106486816(TAB2)

AROW:

112974544(TAB2)

NPD:	112951648(TAB2)

TGT:	104569901(TAB2)

DNE:	112983277(TAB2)

SCAM:

104151181(TAB2)

ASN:	102386987(TAB2)

AMJ:	102567745(TAB2)

CPOO:

109320128(TAB2)

GGN:	109304564(TAB2)

PSS:	102451479(TAB2)

CMY:	102941166(TAB2)

CCAY:

125634062(TAB2)

DCC:	119852884(TAB2)

CPIC:

101945138(TAB2)

TST:	117874855(TAB2)

CABI:

116819784(TAB2)

MRV:	120400767(TAB2)

ACS:	100553005(tab2)

ASAO:

132761043(TAB2)

PVT:	110087432(TAB2)

SUND:

121916815(TAB2)

PBI:

103054952

PMUR:

107287407(TAB2)

CTIG:

120309542(TAB2)

TSR:	106552457(TAB2)

PGUT:

117666352(TAB2)

APRI:

131191591(TAB2)

PTEX:

113439674(TAB2)

NSS:	113411242(TAB2)

VKO:	123019868(TAB2)

PMUA:

114594237(TAB2)

PRAF:

128410637(TAB2)

ZVI:	118082025(TAB2)

HCG:	128343120(TAB2)

GJA:	107114113(TAB2)

STOW:

125428599(TAB2)

EMC:	129334528(TAB2)

XLA:	108716751(tab2.L) 108717890(tab2.S)

XTR:	100037849(tab2)

NPR:	108789386(TAB2)

RTEM:

120937397(TAB2)

BBUF:

120998562(TAB2)

BGAR:

122935018(TAB2)

MUO:	115466654(TAB2)

GSH:	117356936(TAB2)

DRE:	494163(tab2)

SRX:	107708311 107739913

SANH:

107688309(tab2) 107696859

SGH:	107558968 107568749(tab2)

CCAR:

109070678 109113241

CAUA:

113037720 113063485

CGIB:

127983822

PTET:

122324605(tab2)

LROH:

127162147(tab2)

OMC:	131526712(tab2)

PPRM:

120468311(tab2)

RKG:	130077856(tab2)

MAMB:

125278955(tab2)

CIDE:

127502214

CERY:

137019429(tab2)

MASI:

127409886 127416155

TROS:

130565416(tab2)

TDW:	130434055(tab2)

IPU:

108275278

IFU:	128619228(tab2)

PHYP:

113529084(tab2)

SMEO:

124401369(tab2)

TFD:	113660549(tab2)

TVC:	132854466(tab2)

TRN:	134319847(tab2)

AMEX:

103032786(tab2)

CMAO:

118815291(tab2)

EEE:	113589932(tab2)

CHAR:

105897093(tab2)

TRU:	101069621(tab2)

TFS:	130515883(tab2)

TNG:	GSTEN00003790G001

LCO:	104918319(tab2)

NCC:	104941014(tab2)

TBEN:

117498309(tab2)

CGOB:

115028960(tab2)

PGEO:

117440205(tab2)

GACU:

117538684(tab2)

EMAC:

134876983(tab2)

ELY:	117270933(tab2)

EFO:	125897007(tab2)

PLEP:

121955308(tab2)

SLUC:

116040322(tab2)

ECRA:

117961933(tab2)

ESP:	116705943(tab2)

PFLV:

114573158(tab2)

GAT:	120807983(tab2)

PPUG:

119195078(tab2)

AFB:	129107031(tab2)

CLUM:

117727088(tab2)

PSWI:

130203221(tab2)

MSAM:

119908779(tab2)

SCHU:

122863405(tab2)

CUD:	121521210(tab2)

ALAT:

119012337(tab2)

MZE:	101482482(tab2)

ONL:	100700219(tab2)

OAU:	116316818(tab2)

OLA:	101168511(tab2)

OML:	112158259(tab2)

CSAI:

133418574(tab2)

XMA:	102236763(tab2)

XCO:	114158125(tab2)

XHE:	116734627(tab2)

PRET:

103458018(tab2)

PFOR:

103140747(tab2)

PLAI:

106953813(tab2)

PMEI:

106904317(tab2)

GAF:	122824823(tab2)

PPRL:

129369168(tab2)

CVG:	107093279(tab2)

CTUL:

119789456(tab2)

GMU:	124881924(tab2)

NFU:	107396012(tab2)

KMR:	108246525(tab2)

ALIM:

106537013(tab2)

NWH:	119418724(tab2)

AOCE:

111578164(tab2)

MCEP:

124998805(tab2)

CSEM:

103380596(tab2)

POV:	109632543(tab2)

SSEN:

122784290(tab2)

HHIP:

117758625(tab2)

HSP:	118099163(tab2)

PPLT:

128460487(tab2)

SMAU:

118289901(tab2)

LCF:

108899320

SDU:	111216386(tab2)

SLAL:

111645234(tab2)

XGL:	120789016(tab2)

HCQ:	109524845(tab2)

SSCV:

125990574

SBIA:

133496742(tab2)

PEE:	133416740(tab2)

PTAO:

133468019(tab2)

BPEC:

110158440(tab2)

MALB:

109968091(tab2)

BSPL:

114849544(tab2)

SJO:	128377212(tab2)

SASA:

106571309 106607744

STRU:

115174890 115194003

OTW:	112217538 112250087

OMY:	110522153 110529530

OGO:	123990682 123995018

ONE:	115107680 115139492

OKI:	109866705(tab2) 109900675

OKE:	118386818(tab2) 118398736

SALP:

111954242 112068181

SNH:	120019676 120024108

CCLU:

121548996 121552425

ELS:	105017897(tab2)

SFM:	108929403(tab2)

PKI:	111843039(tab2)

AANG:

118230136(tab2) 118237107

LOC:	102694529(tab2)

PSPA:

121315825 121316944(tab2)

ARUT:

117403068 117411419

PSEX:

120525344(tab2)

LCM:	102364705(TAB2)

CMK:	103179281(tab2)

RTP:	109917334(tab2)

CPLA:

122553035(tab2)

HOC:	132819859(tab2)

LERI:

129699346(tab2)

PMRN:

116953394(TAB2)

LRJ:	133351950(TAB2)

CIN:

100186829

SCLV:

120347167

SPU:

591886

DME:	Dmel_CG7417(Tab2)

DER:

6547204

DSE:

6609916

DSI:	Dsimw501_GD11443(Dsim_GD11443)

DYA:	Dyak_GE12037

DAN:

DSR:

DPO:

DPE:

DMN:	108160270 117193439

DWI:

6637980

DGR:

6568788

DMO:	Dmoj_GI18499

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

MDE:

SCAC:

LCQ:

LSQ:

ACOZ:

AARA:

AMER:

ASTE:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ000820

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105671382(Tab2)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

TCA:	657352(Tab2)

DPA:

SOY:

ATD:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_200977

BANY:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

LGLY:

API:

DNX:

AGS:

RMD:

BTAB:

DCI:

NLU:

PHU:	Phum_PHUM268290

FOC:

ZNE:

BROR:

DMK:

PJA:

PCHN:

PCLA:

LSM:

DSV:

VDE:

VJA:

CSCU:

PTEP:

SDM:

LGI:	LOTGIDRAFT_154664

BGT:

HRF:

HRJ:

CRG:

PMAX:

ATEN:

Reference

PMID:10882101

Authors

Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K

Title

TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.

Journal

Mol Cell 5:649-58 (2000)
DOI:10.1016/S1097-2765(00)80244-0

Sequence

[hsa:23118]

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (48)   
   KEGG PATHWAY (48)   
Disease (1)   
   KEGG DISEASE (1)   
Gene (1342)   
   KEGG GENES (566)   
   KEGG MGENES (249)   
   RefGene (525)   
   OC (2)   
Literature (1)   
   PubMed (1)   
All databases (1393)   

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