KEGG ORTHOLOGY: K04412

ORTHOLOGY: K04412

Entry

K04412                      KO

Symbol

STK3, MST2

Name

serine/threonine kinase 3

Pathway

map04010

MAPK signaling pathway

map04214

Apoptosis - fly

map04390

Hippo signaling pathway

map04391

Hippo signaling pathway - fly

map04392

Hippo signaling pathway - multiple species

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04412  STK3, MST2; serine/threonine kinase 3
   04390 Hippo signaling pathway
    K04412  STK3, MST2; serine/threonine kinase 3
   04391 Hippo signaling pathway - fly
    K04412  STK3, MST2; serine/threonine kinase 3
   04392 Hippo signaling pathway - multiple species
    K04412  STK3, MST2; serine/threonine kinase 3
09140 Cellular Processes
  09143 Cell growth and death
   04214 Apoptosis - fly
    K04412  STK3, MST2; serine/threonine kinase 3
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04412  STK3, MST2; serine/threonine kinase 3
Protein kinases [BR:ko01001]
Serine/threonine kinases: STE group
  STE20 family
   K04412  STK3, MST2; serine/threonine kinase 3

Genes

HSA:	6788(STK3)

PTR:	472829(STK3)

PPS:	100992217(STK3)

GGO:	101139712(STK3)

PON:	100172589(STK3)

PPYG:

129043188(STK3)

NLE:	100587096(STK3)

HMH:	116813464(STK3)

SSYN:

129486654(STK3)

MCC:	707425(STK3)

MCF:	101925889(STK3)

MTHB:

126961142

MNI:	105476082(STK3)

CSAB:

103237196(STK3)

CATY:

105586525(STK3)

PANU:

101010619(STK3)

TGE:	112629923(STK3)

MLEU:

105553853(STK3)

RRO:	104679882(STK3)

RBB:	108542507(STK3)

TFN:	117078829(STK3)

PTEH:

111520894 113224962(STK3)

CANG:

105519405(STK3)

CJC:	100387692(STK3)

SBQ:	101044498(STK3)

CIMI:

108286879(STK3)

ANAN:

105719654(STK3)

MMUR:

105869885(STK3)

LCAT:

123637104 123644561(STK3)

PCOQ:

105809799(STK3)

OGA:	100964932(STK3)

MMU:	56274(Stk3)

MCAL:

110310568(Stk3)

MPAH:

110334720(Stk3)

RNO:	65189(Stk3)

MCOC:

116082317(Stk3)

ANU:	117719155(Stk3)

MUN:	110540558(Stk3)

CGE:	100763795(Stk3)

MAUA:

101834979(Stk3)

PROB:

127235366(Stk3)

PLEU:

114703630(Stk3)

MORG:

121437693(Stk3)

MFOT:

126513415

AAMP:

119822913(Stk3)

NGI:	103732823(Stk3)

HGL:	101715099(Stk3)

CPOC:

100729700(Stk3)

CCAN:

109688653(Stk3)

DORD:

105982844(Stk3)

DSP:	122102370(Stk3)

PLOP:

125360924(Stk3)

NCAR:

124992491

MMMA:

107142753(Stk3)

OCU:

100357564

OPI:	101520805(STK3)

TUP:	102498416(STK3)

GVR:	103593030(STK3) 103603673

CFA:	475045(STK3)

CLUD:

112662539(STK3)

VVP:	112916924(STK3)

VLG:	121498796(STK3)

NPO:	129495738(STK3)

AML:	100464802(STK3)

UMR:	103661633(STK3)

UAH:	113252886(STK3)

UAR:	123797846(STK3)

ELK:

111146471

LLV:

125097698

MPUF:

101675790(STK3)

MNP:	132014196(STK3)

MLK:	131826559(STK3)

NVS:	122904404(STK3)

ORO:	101364004(STK3)

EJU:	114216713(STK3)

ZCA:	113912884(STK3)

MLX:	118015058(STK3)

NSU:	110579145(STK3)

LWW:	102732656(STK3)

FCA:	101081440(STK3)

PYU:	121042759(STK3)

PCOO:

112859299(STK3)

PBG:	122495651(STK3)

PVIV:

125156405(STK3)

LRUF:

124519030

PTG:	102972219(STK3)

PPAD:

109278027(STK3)

PUC:	125917075 125924230

AJU:

106983846

HHV:	120247534(STK3)

BTA:	533815(STK3)

BOM:	102270134(STK3)

BIU:	109568496(STK3)

BBUB:

102414176(STK3)

BBIS:

105005538(STK3)

CHX:	102191439(STK3)

OAS:	101106085(STK3)

BTAX:

128059540(STK3)

ODA:	120878440(STK3)

CCAD:

122451521(STK3)

MBEZ:

129560363(STK3)

SSC:	100524741(STK3)

CFR:	102508082(STK3)

CBAI:

105069608(STK3)

CDK:	105090573(STK3)

VPC:	102535285(STK3)

BACU:

103012811(STK3)

BMUS:

118883648(STK3) 118905099

LVE:	103072304(STK3)

OOR:	101278418(STK3)

DLE:	111180390(STK3)

PCAD:

102973938(STK3)

PSIU:

116742624(STK3) 116763697

NASI:

112401545 112407351(STK3)

ECB:	100060508(STK3)

EPZ:	103555870(STK3)

EAI:	106835440(STK3)

MYB:	102253240(STK3)

MYD:	102759803(STK3)

MMYO:

118670667(STK3)

MLF:	102424124(STK3)

MDT:	132219684(STK3)

PKL:	118718187(STK3)

EFUS:

103292317(STK3)

MNA:	107526150(STK3)

DRO:	112315573(STK3)

SHON:

118988550(STK3) 118994351

AJM:	119038558(STK3)

PDIC:

114514493(STK3)

PHAS:

123833073(STK3)

MMF:	118631699(STK3)

PPAM:

129084238(STK3)

HAI:	109382813(STK3)

RFQ:	117033917(STK3)

PALE:

102897363(STK3)

PGIG:

120595596(STK3)

PVP:	105300612(STK3)

RAY:	107517276(STK3)

MJV:	108401845(STK3)

TOD:	119239178(STK3)

SARA:

101538575(STK3)

SETR:

126009450(STK3)

LAV:	100670509(STK3)

TMU:

101355756

ETF:	101646100(STK3)

DNM:	101419458(STK3)

MDO:	100030422 103105479

GAS:	123240899(STK3)

SHR:	100933711(STK3)

AFZ:

127544323

PCW:	110196020(STK3)

TVP:	118848351(STK3)

OAA:	100083303(STK3)

GGA:	425375(STK3)

PCOC:

116227641(STK3)

MGP:	100547673(STK3)

CJO:	107310441(STK3)

TPAI:

128091367(STK3)

LMUT:

125691076(STK3)

NMEL:

110393364(STK3)

APLA:

101796457(STK3)

ACYG:

106035282(STK3)

CATA:

118247932(STK3)

AFUL:

116485467(STK3)

TGU:	100228853(STK3)

LSR:	110470068(STK3)

SCAN:

103813772(STK3)

PMOA:

120500761(STK3)

OTC:	121340270(STK3)

PRUF:

121355423(STK3)

GFR:	102041006(STK3)

FAB:	101814337(STK3)

OMA:	130249743(STK3)

PHI:	102108615(STK3)

PMAJ:

107200357(STK3)

CCAE:

111924510(STK3)

CCW:	104692727(STK3)

CBRC:

103613000(STK3)

ETL:	114066049(STK3)

ZAB:	102069980(STK3)

ZLE:	135444565(STK3)

ACHL:

103810726(STK3)

SVG:	106855269(STK3)

MMEA:

130573676(STK3)

HRT:	120756805(STK3)

SATI:

136370565(STK3)

FPG:	101919634(STK3)

FCH:	102052175(STK3)

SHAB:

115619345(STK3)

ACUN:

113476167(STK3)

TALA:

104364413(STK3)

ACHC:

115340251(STK3)

HALD:

104320568(STK3)

HLE:	104837732(STK3)

AGEN:

GCL:

CSTI:

MNB:

DPUB:

104298132(STK3)

AVIT:

104273317

EGZ:	104125823(STK3)

NNI:	104016433(STK3)

PCRI:

104034227

PADL:

103917315(STK3)

AFOR:

103895810(STK3)

CLV:	102088301(STK3)

MUI:	104537824(STK3)

PGUU:

104469937(STK3)

PLET:

104616426(STK3)

CUCA:

104056729(STK3)

BREG:

104635104

OHA:	104332133(STK3)

ACAR:

104522593 104532145

CPEA:

104396661(STK3)

CVF:	104292441(STK3)

RTD:	128904855(STK3)

AAM:	106483864(STK3)

AROW:

112961605

NPD:	112956500(STK3)

TGT:

104573617

DNE:	112982971(STK3)

SCAM:

104144795(STK3)

ASN:

102371773

AMJ:	102562825(STK3)

CPOO:

109320837(STK3)

GGN:	109305082(STK3)

PSS:

102463813

CMY:	102930624(STK3)

CCAY:

125632709(STK3)

DCC:	119851727(STK3)

CPIC:

101939350(STK3)

TST:	117873700(STK3)

CABI:

116820844(STK3)

MRV:	120397782(STK3)

ACS:	100563011(stk3)

ASAO:

132775015(STK3)

PVT:	110074755(STK3)

SUND:

121929401(STK3)

PBI:	103064033(STK3)

PMUR:

107285264(STK3)

CTIG:

120301531(STK3)

TSR:	106544547(STK3)

PGUT:

117668539(STK3)

APRI:

131194518(STK3)

PTEX:

113439872(STK3)

NSS:	113427918(STK3)

VKO:	123020535(STK3)

PMUA:

114600383(STK3)

PRAF:

128417200(STK3)

ZVI:	118090424(STK3)

HCG:	128324159(STK3)

GJA:	107105835(STK3)

STOW:

125439205(STK3)

EMC:	129333271(STK3)

XLA:	108719348 432210(stk3.S)

XTR:	100036637(stk3)

NPR:	108789153(STK3)

RTEM:

120941416(STK3)

BBUF:

121001381(STK3)

BGAR:

122938792(STK3)

MUO:	115479305(STK3)

GSH:	117355676(STK3)

DRE:	324125(stk3)

SRX:	107710087 107724280

SANH:

107653827 107702102

SGH:	107556381 107579303

CCAR:

109091699

CAUA:

113091881 113119464

CGIB:

127935633 127979327

PTET:

122323703(stk3)

LROH:

127182233(stk3)

OMC:	131526345(stk3)

PPRM:

120485308(stk3)

RKG:	130069798(stk3)

MAMB:

125274865(stk3)

CIDE:

127501360

CERY:

137037279(stk3)

MASI:

127421461 127425742

TROS:

130566821(stk3)

MANU:

129454686(stk3)

IPU:

108256932

IFU:	128600425(stk3)

PHYP:

113536008(stk3)

SMEO:

124376097(stk3)

TFD:	113661534(stk3)

TVC:	132863797(stk3)

TRN:	134332825(stk3)

AMEX:

103027492(stk3)

CMAO:

118805484(stk3)

EEE:	113575026(stk3)

CHAR:

105907728(stk3)

TRU:

101074579

TFS:	130518685(stk3)

TNG:	GSTEN00017365G001

LCO:	104918642(stk3)

NCC:	104942286(stk3)

TBEN:

117478427(stk3)

CGOB:

115015637

PGEO:

117454650(stk3)

GACU:

117536162(stk3)

EMAC:

134874710(stk3)

ELY:	117263866(stk3)

EFO:	125904740(stk3)

PLEP:

121957455(stk3)

SLUC:

116047412(stk3)

ECRA:

117956560(stk3)

ESP:	116701356(stk3)

PFLV:

114567693(stk3)

GAT:	120826522(stk3)

PPUG:

119219155(stk3)

AFB:	129097170(stk3)

CLUM:

117738685(stk3)

PSWI:

130191576(stk3)

MSAM:

119907170(stk3)

SCHU:

122864127(stk3)

CUD:	121523366(stk3)

ALAT:

119017120(stk3)

MZE:

101476981

ONL:	100711192(stk3)

OAU:	116322428(stk3)

OLA:

101155570

OML:	112137115(stk3)

CSAI:

133461479(stk3)

XMA:	102233124(stk3)

XCO:	114155406(stk3)

XHE:	116731415(stk3)

PRET:

103472439(stk3)

PFOR:

103135175

PLAI:

106938036

PMEI:

106904805

GAF:	122844201(stk3)

PPRL:

129374962(stk3)

CVG:	107087847(stk3)

CTUL:

119784827(stk3)

GMU:	124878985(stk3)

NFU:	107394672(stk3)

KMR:	108242124(stk3)

ALIM:

106518168(stk3)

NWH:	119425776(stk3)

AOCE:

111582357

MCEP:

125019535(stk3)

CSEM:

103394381

POV:

109638820

SSEN:

122786508(stk3)

HHIP:

117770168(stk3)

HSP:	118124989(stk3)

PPLT:

128461655(stk3)

SMAU:

118292184(stk3)

LCF:

108898178

SDU:

111223193

SLAL:

111659275

XGL:	120786763(stk3)

HCQ:	109514570(stk3)

SSCV:

125987223

SBIA:

133500063(stk3)

PEE:	133396079(stk3)

PTAO:

133471260(stk3)

BPEC:

110167165(stk3)

MALB:

109958752(stk3)

BSPL:

114865454(stk3)

SJO:	128374055(stk3)

SASA:

106570786 106570788

STRU:

115176248 115190950

OTW:	112236197(stk3) 112236591

OMY:	110487814(stk3) 110496773

OGO:	124013090 124030302 124043109(stk3)

ONE:

115125864

OKI:	109880496 109883391

OKE:	118374322 118375478

SALP:

112073738

SNH:	120026944(stk3)

CCLU:

121555490(stk3) 121556430

ELS:

105027710

SFM:	108940739(stk3)

PKI:	111845084(stk3)

AANG:

118230831 118234538

LOC:

102694627

PSPA:

121313233 121314948(stk3)

ARUT:

117400326 117435557

PSEX:

120515344(stk3)

LCM:	102346204 102354528

CMK:	103179698(stk3)

RTP:

109921319

CPLA:

122548834(stk3)

HOC:	132815109(stk3)

LERI:

129696052(stk3)

PMRN:

116941643 116957785

LRJ:	133340782 133340786 133344036 133344189

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

ARUN:

AJC:

SKO:

DME:	Dmel_CG11228(hpo)

DER:

6547406

DSE:

6609956

DSI:	Dsimw501_GD25317(Dsim_GD25317)

DYA:	Dyak_GE13841

DAN:

DSR:

DPO:

DPE:

DMN:	108159337 117187752

DWI:

6640692

DGR:

6568702

DMO:	Dmoj_GI20569

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108361493 108377946

AOQ:

129243701

TDA:

119677319

MDE:	101891073 131805607

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ000288

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:	114871568 114871676

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105675764(hpo)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:	109541048 109545862

SOY:

115876783

AGRG:

126747948 126748662

ATD:	109608659 109609445

CSET:

123321339

AGB:

108906768

LDC:

111503645

DVV:	114328228 114332539

NVL:

APLN:

PPYR:

OTU:

BMOR:

100144578(HPO)

BMAN:

114241218

MSEX:

115440802

DPL:	KGM_210615

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:	110381233(hpo)

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

API:	100165384 100168569

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106683883(hpo)

NLU:

111047170

HVI:

124363259

MQU:	128988680 128988912

PHU:	Phum_PHUM617080

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_211626

DMK:

116916680

DPZ:

124314066

PVM:	113809965 113816519

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:	107361829 107364714

DPTE:

113799193

DFR:

124494475

CSCU:

111630343

CVS:	136988468(hpo)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_C24A8.4(cst-2) CELE_F14H12.4(cst-1)

CBR:	CBG_14395(Cbr-cst-1)

CRQ:	GCK72_024235

BMY:	BM_BM3378(Bm3378)

LOA:	LOAG_07747

TSP:

Tsp_03757

HRO:	HELRODRAFT_64347

LGI:	LOTGIDRAFT_130700

PVUL:

126829408

PCAN:

112561016

BGT:	106059440 106059443

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_081410

SHX:	MS3_00004635(STK4)

OVI:	T265_15196

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:	114528586 114540978

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_32096

AQU:

100631652

MBR:	MONBRDRAFT_11609

DDI:	DDB_G0273121(pakH-1) DDB_G0273865(pakH-2)

DPP:	DICPUDRAFT_90051

DFA:	DFA_02105(pakH-2)

EHI:	EHI_156670(242.t00007)

EDI:	EDI_102210

ACAN:

ACA1_038090 ACA1_072940 ACA1_366920

PIF:	PITG_06107

PSOJ:

PHYSODRAFT_515065

EHX:	EMIHUDRAFT_464243 EMIHUDRAFT_467901

NGR:	NAEGRDRAFT_80621

TVA:	TVAG_2v0054930 TVAG_2v0056650 TVAG_2v0214670 TVAG_2v0784530

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Reference

PMID:15688006

Authors

Chan EH, Nousiainen M, Chalamalasetty RB, Schafer A, Nigg EA, Sillje HH

Title

The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1.

Journal

Oncogene 24:2076-86 (2005)
DOI:10.1038/sj.onc.1208445

Sequence

[hsa:6788]

Reference

PMID:14502294

Authors

Udan RS, Kango-Singh M, Nolo R, Tao C, Halder G

Title

Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway.

Journal

Nat Cell Biol 5:914-20 (2003)
DOI:10.1038/ncb1050

Reference

PMID:8566796

Authors

Creasy CL, Chernoff J

Title

Cloning and characterization of a member of the MST subfamily of Ste20-like kinases.

Journal

Gene 167:303-6 (1995)
DOI:10.1016/0378-1119(95)00653-2

Sequence

[hsa:6788]

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (10)   
   KEGG PATHWAY (10)   
Gene (2840)   
   KEGG GENES (721)   
   KEGG MGENES (220)   
   RefGene (1889)   
   OC (10)   
Literature (3)   
   PubMed (3)   
All databases (2855)   

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