KEGG ORTHOLOGY: K04416

ORTHOLOGY: K04416

Entry

K04416                      KO

Symbol

MAP3K1, MEKK1

Name

mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]

Pathway

map04010

MAPK signaling pathway

map04120

Ubiquitin mediated proteolysis

map04530

Tight junction

map04622

RIG-I-like receptor signaling pathway

map04722

Neurotrophin signaling pathway

map04912

GnRH signaling pathway

map04935

Growth hormone synthesis, secretion and action

map05161

Hepatitis B

map05166

Human T-cell leukemia virus 1 infection

Disease

H00607

46,XY gonadal dysgenesis

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
09150 Organismal Systems
  09151 Immune system
   04622 RIG-I-like receptor signaling pathway
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
   04935 Growth hormone synthesis, secretion and action
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
   05161 Hepatitis B
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
Protein kinases [BR:ko01001]
Serine/threonine kinases: STE group
  STE11 family
   K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1

Other DBs

GO:

0004709

Genes

HSA:	4214(MAP3K1)

PTR:	471543(MAP3K1)

PPS:	100994796(MAP3K1)

GGO:	101136722(MAP3K1)

PON:	100453309(MAP3K1)

PPYG:

129036502(MAP3K1)

NLE:	100606554(MAP3K1)

HMH:	116462248(MAP3K1)

SSYN:

129467235(MAP3K1)

MCC:	710979(MAP3K1)

MCF:	102123041(MAP3K1)

MTHB:

126957142

MNI:	105499405(MAP3K1)

CSAB:

103221701(MAP3K1)

CATY:

105599635(MAP3K1)

PANU:

100137396(MAP3K1)

TGE:	112626113(MAP3K1)

MLEU:

105553734(MAP3K1)

RRO:	104657086(MAP3K1)

RBB:	108530959(MAP3K1)

TFN:	117065147(MAP3K1)

PTEH:

111541624(MAP3K1)

CANG:

105512468(MAP3K1)

CJC:	100389500(MAP3K1)

SBQ:	101054366(MAP3K1)

CIMI:

108317984(MAP3K1)

ANAN:

105720652(MAP3K1)

CSYR:

103277203(MAP3K1)

MMUR:

105877272(MAP3K1)

LCAT:

123647994(MAP3K1)

PCOQ:

105819135(MAP3K1)

OGA:	100957675(MAP3K1)

MMU:	26401(Map3k1)

MCAL:

110307741(Map3k1)

MPAH:

110328949(Map3k1)

RNO:	116667(Map3k1)

MCOC:

116083778(Map3k1)

ANU:	117723859(Map3k1)

MUN:	110546648(Map3k1)

CGE:	100770540(Map3k1)

MAUA:

101843009(Map3k1)

PROB:

127221136(Map3k1)

PLEU:

114702950(Map3k1)

MORG:

121455832(Map3k1)

MFOT:

126507983

AAMP:

119809929(Map3k1)

NGI:	103739909(Map3k1)

HGL:	101720769(Map3k1)

CPOC:

100723456(Map3k1)

CCAN:

109695531(Map3k1)

DORD:

105987286(Map3k1)

DSP:	122117204(Map3k1)

PLOP:

125367414(Map3k1)

NCAR:

124986862

MMMA:

107151930(Map3k1)

OCU:

100348484

OPI:	101528866(MAP3K1)

TUP:	102483890(MAP3K1)

GVR:	103600330(MAP3K1)

CFA:	478061(MAP3K1)

CLUD:

112659920(MAP3K1)

VVP:	112935233(MAP3K1)

VLG:	121497450(MAP3K1)

NPO:	129513743(MAP3K1)

AML:	100466442(MAP3K1)

UMR:	103663891(MAP3K1)

UAH:	113255319(MAP3K1)

UAR:	123790179(MAP3K1)

ELK:

111156879

LLV:

125101058

MPUF:

101689561(MAP3K1)

MNP:	132028649(MAP3K1)

MLK:	131832249(MAP3K1)

NVS:	122889387(MAP3K1)

ORO:	101366511(MAP3K1)

EJU:	114221009(MAP3K1)

ZCA:	113929708(MAP3K1)

MLX:	118016799(MAP3K1)

NSU:	110591252(MAP3K1)

LWW:	102748780(MAP3K1)

FCA:	101090328(MAP3K1)

PYU:	121015675(MAP3K1)

PCOO:

112860595(MAP3K1)

PBG:	122489134(MAP3K1)

PVIV:

125155054(MAP3K1)

LRUF:

124517338

PTG:	102971191(MAP3K1)

PPAD:

109246346(MAP3K1)

PUC:

125935639

AJU:

106975243

HHV:	120239952(MAP3K1)

BTA:	523962(MAP3K1)

BOM:	102267592(MAP3K1)

BIU:	109574889(MAP3K1)

BBUB:

102399327(MAP3K1)

BBIS:

104998375(MAP3K1)

CHX:	102187530(MAP3K1)

OAS:	101112260(MAP3K1)

BTAX:

128065982(MAP3K1)

ODA:	120879530(MAP3K1)

CCAD:

122454236(MAP3K1)

MBEZ:

129553244(MAP3K1)

SSC:	396617(MAP3K1)

CFR:	102505358(MAP3K1)

CBAI:

105077858(MAP3K1)

CDK:	105087133(MAP3K1)

VPC:	102530799(MAP3K1)

BACU:

103002185(MAP3K1)

BMUS:

118892091(MAP3K1)

LVE:	103083385(MAP3K1)

OOR:	101288918(MAP3K1)

DLE:	111186550(MAP3K1)

PCAD:

102979076(MAP3K1)

PSIU:

116750695(MAP3K1)

NASI:

112413424(MAP3K1)

ECB:	100061688(MAP3K1)

EPZ:	103548212(MAP3K1)

EAI:	106843371(MAP3K1)

MYB:	102258632(MAP3K1)

MYD:	102763786(MAP3K1)

MMYO:

118656004(MAP3K1)

MLF:	102425420(MAP3K1)

MDT:	132233809(MAP3K1)

PKL:	118702681(MAP3K1)

EFUS:

103303283(MAP3K1)

MNA:	107527145(MAP3K1)

DRO:	112315269(MAP3K1)

SHON:

118981725(MAP3K1)

AJM:	119039781(MAP3K1)

PDIC:

114512339(MAP3K1)

PHAS:

123819501(MAP3K1)

MMF:	118642468(MAP3K1)

PPAM:

129071974(MAP3K1)

HAI:	109385705(MAP3K1)

RFQ:	117025303(MAP3K1)

PALE:

102886741(MAP3K1)

PGIG:

120608191(MAP3K1)

PVP:	105299360(MAP3K1)

RAY:	107518617(MAP3K1)

MJV:	108384016(MAP3K1)

TOD:	119261148(MAP3K1)

SARA:

101554394(MAP3K1)

SETR:

126001850(MAP3K1)

LAV:	100655149(MAP3K1)

TMU:

101361190

ETF:	101645836(MAP3K1)

DNM:	101446968(MAP3K1)

MDO:	100032065(MAP3K1)

GAS:	123251773(MAP3K1)

SHR:	100913571(MAP3K1)

AFZ:

127557574

PCW:	110215703(MAP3K1)

TVP:	118852694(MAP3K1)

OAA:	100076612(MAP3K1)

GGA:	427144(MAP3K1)

PCOC:

116239413(MAP3K1)

MGP:	100550623(MAP3K1)

CJO:	107306009(MAP3K1)

TPAI:

128074502(MAP3K1)

LMUT:

125686479(MAP3K1)

NMEL:

110390387(MAP3K1)

APLA:

101793656(MAP3K1)

ACYG:

106035615(MAP3K1)

CATA:

118251484(MAP3K1)

AFUL:

116501197(MAP3K1) 116501286

TGU:	100225825(MAP3K1)

LSR:	110472556(MAP3K1)

SCAN:

103821035(MAP3K1)

PMOA:

120502387(MAP3K1)

OTC:	121341271(MAP3K1)

PRUF:

121355416(MAP3K1)

GFR:	102044899(MAP3K1)

FAB:	101807669(MAP3K1)

OMA:	130264693(MAP3K1)

PHI:	102103765(MAP3K1)

PMAJ:

107216401(MAP3K1)

CCAE:

111941445(MAP3K1)

CCW:	104686679(MAP3K1)

CBRC:

103623840(MAP3K1)

ETL:	114055129(MAP3K1)

ZAB:	102064872(MAP3K1)

ZLE:	135459666(MAP3K1)

ACHL:

103802285(MAP3K1)

SVG:	106859615(MAP3K1)

MMEA:

130588760(MAP3K1)

HRT:	120765209(MAP3K1)

SATI:

136374098(MAP3K1)

FPG:	101911178(MAP3K1)

FCH:	102045898(MAP3K1)

CCRI:

104157655(MAP3K1)

NNT:	104404511(MAP3K1)

SHAB:

115619838(MAP3K1)

ACUN:

113489657(MAP3K1)

TALA:

104368466(MAP3K1)

ACHC:

115336915(MAP3K1) 121232898

HALD:

104319316(MAP3K1)

HLE:	104839945(MAP3K1)

AGEN:

126035238 126036143

GCL:	127027572 127027897

CSTI:

104555906(MAP3K1)

LDI:	104344750(MAP3K1)

MNB:	103781380(MAP3K1)

DPUB:

104306360(MAP3K1)

AVIT:

104267069(MAP3K1)

BRHI:

104497099(MAP3K1)

EGZ:	104134700(MAP3K1)

NNI:	104011958(MAP3K1)

PCRI:

104027050(MAP3K1)

PCAO:

104051671(MAP3K1)

PADL:

103919424(MAP3K1)

AFOR:

103893397(MAP3K1)

FGA:	104070375(MAP3K1)

GSTE:

104256897(MAP3K1)

CLV:	102097744(MAP3K1)

MUI:	104539629(MAP3K1)

PGUU:

104472227(MAP3K1)

PLET:

104624748(MAP3K1)

EHS:	104506271(MAP3K1)

CMAC:

104486221(MAP3K1)

CUCA:

104054786(MAP3K1)

TEO:	104377698(MAP3K1)

BREG:

104629986(MAP3K1)

OHA:	104337710(MAP3K1)

ACAR:

104526017(MAP3K1)

CPEA:

104395629(MAP3K1)

CVF:	104287132 104294997(MAP3K1)

RTD:	128902090 128902447(MAP3K1)

AROW:

112970357(MAP3K1)

NPD:	112945646(MAP3K1)

TGT:	104571239(MAP3K1)

DNE:	112995770(MAP3K1)

SCAM:

104146859(MAP3K1)

ASN:	102376941(MAP3K1)

AMJ:	102562794(MAP3K1)

CPOO:

109307929(MAP3K1)

GGN:	109297803(MAP3K1)

PSS:	102463619(MAP3K1)

CMY:	102938448(MAP3K1)

CCAY:

125636790(MAP3K1)

DCC:	119855899(MAP3K1)

CPIC:

101933464(MAP3K1)

TST:	117878807(MAP3K1)

CABI:

116821886(MAP3K1)

MRV:	120407790(MAP3K1)

ACS:	100561745(map3k1)

ASAO:

132766999(MAP3K1)

PVT:	110085400(MAP3K1)

SUND:

121922484(MAP3K1)

PBI:	103048285(MAP3K1)

PMUR:

107292307(MAP3K1)

CTIG:

120313485(MAP3K1)

TSR:	106540861(MAP3K1)

PGUT:

117679202(MAP3K1)

PTEX:

113446900(MAP3K1)

NSS:	113413899(MAP3K1)

VKO:	123031252(MAP3K1)

PMUA:

114606892(MAP3K1)

PRAF:

128423443(MAP3K1)

ZVI:	118077342(MAP3K1)

HCG:	128346246(MAP3K1)

GJA:	107123377(MAP3K1)

STOW:

125436396(MAP3K1)

EMC:	129334303(MAP3K1)

XLA:	108704427(map3k1.S) 108718321(map3k1.L)

XTR:	100490504(map3k1)

NPR:	108792018(MAP3K1)

RTEM:

120928469(MAP3K1)

BBUF:

120992144(MAP3K1)

BGAR:

122925179(MAP3K1)

MUO:	115461877 115462999(MAP3K1)

GSH:	117366354(MAP3K1)

DRE:	100334486(map3k1)

SRX:	107715839 107737160

SANH:

107670047 107702559

SGH:	107558252 107560413(map3k1)

CCAR:

109097257 109097258

CAUA:

113053991 113109546

CGIB:

127965952 128021431

PTET:

122352837(map3k1)

LROH:

127171924(map3k1)

OMC:	131547897(map3k1)

PPRM:

120481914(map3k1)

RKG:	130069364(map3k1)

MAMB:

125255879(map3k1)

CIDE:

127520635

CERY:

137028945(map3k1)

MASI:

127432324 127433272

TROS:

130545902(map3k1)

TDW:	130411393(map3k1)

MANU:

129445826 129446170

IPU:

108277254

IFU:	128620211(map3k1)

PHYP:

113543563(map3k1)

SMEO:

124393433(map3k1)

TFD:	113639281(map3k1)

TVC:	132863073(map3k1)

TRN:	134332431(map3k1)

AMEX:

103042517(map3k1)

CMAO:

118825293(map3k1)

EEE:	113576764(map3k1)

CHAR:

105894653(map3k1)

SASA:

106562896 106571505(map3k1)

STRU:

115160088(map3k1)

OTW:	112220130(map3k1) 112230734

OMY:	110523170(map3k1)

OGO:	123989496(map3k1)

ONE:	115118152(map3k1) 115147124

OKI:	109868623(map3k1) 109875910

OKE:	118385561 118387265

SALP:

111961944(map3k1) 111963818

SNH:	120020909 120026372(map3k1)

CCLU:

121541398 121581971(map3k1)

ELS:	105021721(map3k1)

SFM:	108929962(map3k1)

PKI:	111834485(map3k1)

AANG:

118206649 118212807(map3k1)

LOC:	102683229(map3k1)

PSPA:

121300913 121316750

ARUT:

117425788 117963658

PSEX:

120532605(map3k1)

LCM:	102355070(MAP3K1)

CMK:	103177870(map3k1)

CPLA:

122549355(map3k1)

HOC:	132814043(map3k1)

LERI:

129696539(map3k1)

PMRN:

116943573 116948801

LRJ:	133346374 133351879

BFO:

BBEL:

SCLV:

SPU:

APLC:

ARUN:

SKO:

FOC:

TPAL:

ZNE:

CSEC:

PVM:

PJA:

PCHN:

HAME:

PCLA:

PTRU:

HAZT:

EAF:

LSM:

DSV:

RSAN:

RMP:

LGI:	LOTGIDRAFT_162448

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MMER:

OBI:

OSN:

LJP:

LAK:	106170548 106177880

SMM:	Smp_050380

OVI:	T265_07440

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

TAD:	TRIADDRAFT_28738

SRE:	PTSG_10004

» show all

Reference

PMID:12049732

Authors

Lu Z, Xu S, Joazeiro C, Cobb MH, Hunter T

Title

The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2.

Journal

Mol Cell 9:945-56 (2002)
DOI:10.1016/S1097-2765(02)00519-1

Reference

PMID:9808624

Authors

Xia Y, Wu Z, Su B, Murray B, Karin M

Title

JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension.

Journal

Genes Dev 12:3369-81 (1998)
DOI:10.1101/gad.12.21.3369

Sequence

[hsa:4214]

All links

Ontology (5)   
   KEGG BRITE (4)   
   GO (1)   
Pathway (18)   
   KEGG PATHWAY (18)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2093)   
   KEGG GENES (412)   
   KEGG MGENES (521)   
   RefGene (1156)   
   OC (4)   
Literature (2)   
   PubMed (2)   
All databases (2120)   

Download RDF

ORTHOLOGY: K04421

Entry

K04421                      KO

Symbol

MAP3K3, MEKK3

Name

mitogen-activated protein kinase kinase kinase 3 [EC:2.7.11.25]

Pathway

map04010

MAPK signaling pathway

map04722

Neurotrophin signaling pathway

map04912

GnRH signaling pathway

map05166

Human T-cell leukemia virus 1 infection

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3
09150 Organismal Systems
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3
09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3
Protein kinases [BR:ko01001]
Serine/threonine kinases: STE group
  STE11 family
   K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3

Other DBs

GO:

0004709

Genes

HSA:	4215(MAP3K3)

PTR:	468286(MAP3K3)

PPS:	100969705(MAP3K3)

GGO:	101148044(MAP3K3)

PON:	100444678(MAP3K3)

PPYG:

129017940(MAP3K3)

NLE:	100601763(MAP3K3)

HMH:	116458740(MAP3K3)

SSYN:

129470636(MAP3K3)

MCC:	717866(MAP3K3)

MCF:	102132095(MAP3K3)

MTHB:

126939545

MNI:	105483039(MAP3K3)

CSAB:

103243225(MAP3K3)

CATY:

105590736(MAP3K3)

PANU:

101023704(MAP3K3)

TGE:	112608888(MAP3K3)

MLEU:

105551719(MAP3K3)

RRO:	104675466(MAP3K3)

RBB:	108536280(MAP3K3)

TFN:	117067436(MAP3K3)

PTEH:

111527597(MAP3K3)

CANG:

105515973(MAP3K3)

CJC:	100409608(MAP3K3)

SBQ:	101035755(MAP3K3) 101043439

CIMI:

108318261(MAP3K3)

ANAN:

105711209(MAP3K3)

CSYR:

103252889(MAP3K3)

MMUR:

105861627(MAP3K3)

LCAT:

123620590(MAP3K3)

PCOQ:

105824000(MAP3K3)

OGA:	100944704(MAP3K3)

MMU:	26406(Map3k3)

MCAL:

110305762(Map3k3)

MPAH:

110331495(Map3k3)

RNO:	303604(Map3k3)

MCOC:

116076740(Map3k3)

ANU:	117710722(Map3k3)

MUN:	110547048(Map3k3)

CGE:	100753508(Map3k3)

MAUA:

101832971(Map3k3)

PROB:

127218084(Map3k3)

PLEU:

114690404(Map3k3)

MORG:

121436150(Map3k3)

MFOT:

126514953

AAMP:

119812909(Map3k3)

NGI:	103744757(Map3k3)

HGL:	101704335(Map3k3)

CPOC:

100731994(Map3k3)

CCAN:

109703189(Map3k3)

DORD:

105998545(Map3k3)

DSP:	122103464(Map3k3)

PLOP:

125365123(Map3k3)

NCAR:

124979643

MMMA:

107158328(Map3k3)

OCU:

100355324

OPI:	101534751(MAP3K3)

TUP:	102477673(MAP3K3)

GVR:	103589229(MAP3K3)

CFA:	480481(MAP3K3)

CLUD:

112652993(MAP3K3)

VVP:	112920702(MAP3K3)

VLG:	121473381(MAP3K3)

NPO:	129511556(MAP3K3)

AML:	100475740(MAP3K3)

UMR:	103665628(MAP3K3)

UAH:	113265289(MAP3K3)

UAR:	123802932(MAP3K3)

ELK:

111158066

LLV:

125087832

MPUF:

101674882(MAP3K3)

MNP:	132004017(MAP3K3)

MLK:	131816910(MAP3K3)

NVS:	122906090(MAP3K3)

ORO:	101375291(MAP3K3)

EJU:	114196698(MAP3K3)

ZCA:	113939885(MAP3K3)

MLX:	118024385(MAP3K3)

NSU:	110570388(MAP3K3)

LWW:	102734394(MAP3K3)

FCA:	101083633(MAP3K3)

PYU:	121015257(MAP3K3)

PCOO:

112864457(MAP3K3)

PBG:	122485762(MAP3K3)

PVIV:

125151909(MAP3K3)

LRUF:

124513542

PTG:	102966576(MAP3K3)

PPAD:

109277107(MAP3K3)

PUC:

125926671

AJU:

106978686

HHV:	120234206(MAP3K3)

BTA:	508943(MAP3K3)

BOM:	102275307(MAP3K3)

BIU:	109573385(MAP3K3)

BBUB:

102413611(MAP3K3)

BBIS:

105000508(MAP3K3)

CHX:	102173036(MAP3K3)

OAS:	101122537(MAP3K3)

BTAX:

128064421(MAP3K3)

ODA:	120866946(MAP3K3)

CCAD:

122439701(MAP3K3)

MBEZ:

129544535(MAP3K3)

SSC:	100513491(MAP3K3)

CFR:	102505759(MAP3K3)

CBAI:

105069789(MAP3K3)

CDK:	105090412(MAP3K3)

VPC:	102540602(MAP3K3)

BACU:

102999255(MAP3K3)

BMUS:

118886567(MAP3K3)

LVE:	103076636(MAP3K3)

OOR:	101273961(MAP3K3)

DLE:	111182605(MAP3K3)

PCAD:

102985586(MAP3K3)

PSIU:

116745546(MAP3K3)

NASI:

112410489(MAP3K3)

ECB:	100064751(MAP3K3)

EPZ:	103549765(MAP3K3)

EAI:	106835525(MAP3K3)

MYB:	102242308(MAP3K3)

MYD:	102762787(MAP3K3)

MMYO:

118671605(MAP3K3)

MLF:	102442880(MAP3K3)

MDT:	132218565(MAP3K3)

PKL:	118726628(MAP3K3)

EFUS:

103293150(MAP3K3)

MNA:	107530487(MAP3K3)

DRO:	112316249(MAP3K3)

SHON:

119003525(MAP3K3)

AJM:	119036313(MAP3K3)

PDIC:

114502262(MAP3K3)

PHAS:

123816809(MAP3K3)

MMF:	118634916(MAP3K3)

PPAM:

129070196(MAP3K3)

HAI:	109380266(MAP3K3)

RFQ:	117013390(MAP3K3)

PALE:

102889570(MAP3K3)

PGIG:

120600282(MAP3K3)

PVP:	105297731(MAP3K3)

RAY:	107501901(MAP3K3)

MJV:	108401834(MAP3K3)

TOD:	119232633(MAP3K3)

SARA:

101555844(MAP3K3)

SETR:

126017334(MAP3K3)

LAV:	100662122(MAP3K3)

TMU:

101341472

ETF:	101657417(MAP3K3)

DNM:	101410864(MAP3K3)

MDO:	100025970(MAP3K3)

GAS:	123244863(MAP3K3)

SHR:	100933837(MAP3K3)

AFZ:

127560409

PCW:	110215942(MAP3K3)

TVP:	118848119(MAP3K3)

OAA:	100083301 100092024(MAP3K3)

GGA:	419954(MAP3K3) 420419(MAPKKK3L)

PCOC:

116233811(MAP3K3) 116238245

MGP:	100542691 100542719(MAP3K3)

CJO:	107308787 107325133(MAP3K3)

TPAI:

128087323 128088727(MAP3K3)

LMUT:

125684649(MAP3K3) 125695837

NMEL:

110388470(MAP3K3) 110394259

APLA:

101795869 101801284(MAP3K3)

ACYG:

106036842 106045975(MAP3K3)

CATA:

118251789 118258931(MAP3K3)

AFUL:

116486750 116498376(MAP3K3)

TGU:	100223633(MAP3K3) 100226503

LSR:	110474827(MAP3K3) 110484542

SCAN:

103812700 103821658(MAP3K3)

PMOA:

120498159(MAP3K3) 120510578

OTC:	121338070 121347567(MAP3K3)

PRUF:

121352471(MAP3K3) 121364634

GFR:	102032306(MAP3K3) 102044243

FAB:	101813992(MAP3K3) 101817004

OMA:	130249972 130264032(MAP3K3)

PHI:	102108460 102112033(MAP3K3)

PMAJ:

107200237 107215258(MAP3K3)

CCAE:

111925531 111939927(MAP3K3)

CCW:	104686414 104698629(MAP3K3)

CBRC:

103619882(MAP3K3) 103623939

ETL:	114065134 114066926(MAP3K3)

ZAB:	102061523(MAP3K3) 102068579

ZLE:	135443550 135458685(MAP3K3)

ACHL:

103802063(MAP3K3) 103803986

SVG:	106851598 106861195(MAP3K3)

MMEA:

130573170 130582463(MAP3K3)

HRT:	120752063 120763686(MAP3K3)

SATI:

136358095 136372313(MAP3K3)

FPG:	101912446(MAP3K3) 101923251

FCH:	102047801(MAP3K3) 102050351

CCRI:

104162271(MAP3K3) 104163806

NNT:	104402400 104409913(MAP3K3)

SHAB:

115609418 115617902(MAP3K3)

ACUN:

113477214 113489126(MAP3K3)

TALA:

104365343 104365963(MAP3K3)

ACHC:

115339806 115344350(MAP3K3)

HALD:

104318986(MAP3K3) 104320698

HLE:	104827837 104827981(MAP3K3)

AGEN:

126037884 126038723

GCL:	127013622 127026479

CSTI:

104550852 104562083(MAP3K3)

LDI:	104344381(MAP3K3) 104348091

MNB:	103777222 103778704(MAP3K3)

DPUB:

104298979 104309224(MAP3K3)

AVIT:

104270669 104278271(MAP3K3)

BRHI:

104491398(MAP3K3)

EGZ:	104130961 104134638(MAP3K3)

NNI:	104009891(MAP3K3) 104021753

PCRI:

104027555(MAP3K3) 104038607

PCAO:

104050582 104052496(MAP3K3)

PADL:

103913871(MAP3K3) 103924744

AFOR:

103896151 103906066(MAP3K3)

FGA:	104076924(MAP3K3) 104077842

GSTE:

104254231(MAP3K3) 104259046

CLV:	102085060(MAP3K3) 102088147

MUI:	104534481 104536722(MAP3K3)

PGUU:

104464009 104464263(MAP3K3)

PLET:

104621404 104624166(MAP3K3)

EHS:	104511998(MAP3K3) 104512258

CMAC:

104485993(MAP3K3) 104487253

CUCA:

104054378(MAP3K3) 104056977

TEO:	104379019 104384438(MAP3K3)

BREG:

104632129 104642142(MAP3K3)

OHA:	104337214 104338682(MAP3K3)

ACAR:

104518697 104525494(MAP3K3)

CPEA:

104396174 104398030(MAP3K3)

CVF:	104285380(MAP3K3) 104291263

RTD:	128905604 128919160(MAP3K3)

AAM:	106497426(MAP3K3)

AROW:

112962749(MAP3K3) 112969323

NPD:	112958101 112960230(MAP3K3)

TGT:	104573012(MAP3K3) 104578294

DNE:	112981158 112982786(MAP3K3)

SCAM:

104144774(MAP3K3) 104150762

ASN:	102368863 102374958(MAP3K3)

AMJ:	102572648 106736961(MAP3K3)

CPOO:

109306583 109319002(MAP3K3)

GGN:	109291200 109301682(MAP3K3)

PSS:	102454634(MAP3K3) 102454880

CMY:	102930570(MAP3K3) 102931859

CCAY:

125626662(MAP3K3) 125631186

DCC:	119849034(MAP3K3) 119851757

CPIC:

101948589 101953672(MAP3K3)

TST:	117869137(MAP3K3) 117871989

CABI:

116827890 116839493(MAP3K3)

MRV:	120392173(MAP3K3) 120398118

ACS:	100557698(map3k3) 100562159

ASAO:

132778403(MAP3K3) 132779008

PVT:	110080317(MAP3K3) 110085837

SUND:

121933419(MAP3K3) 121934750

PBI:	103064885 103066986(MAP3K3)

PMUR:

107284356 107302364(MAP3K3)

CTIG:

120302697(MAP3K3) 120313608

TSR:	106540521(MAP3K3) 106545629

PGUT:

117654825 117665021(MAP3K3)

APRI:

131197164(MAP3K3) 131197469

PTEX:

113447218(MAP3K3) 113447966

NSS:	113419489 113420074(MAP3K3)

VKO:	123020993 123031851(MAP3K3)

PMUA:

114581713(MAP3K3) 114607438

PRAF:

128399929(MAP3K3) 128424067

ZVI:	118091861 118094234(MAP3K3)

HCG:	128331714 128332060(MAP3K3)

GJA:

107116392

STOW:

125424924

EMC:

129337981

XLA:	108701764(map3k3.L) 108702560(map3k3.S) 108719812(map3k22.S) 734336(map3k22.L)

XTR:	100488360(map3k22) 100490021(map3k3)

NPR:	108784622 108802493(MAP3K3)

RTEM:

120919516(MAP3K3) 120940127

BBUF:

121002332 121003275(MAP3K3)

BGAR:

122937994 122941234(MAP3K3)

MUO:

115466611

GSH:

117354355

DRE:	100126011(map3k22) 560211(map3k3)

SRX:	107721962 107729565(map3k3) 107741004 107758305

SANH:

107658467 107670426 107674169 107701654

SGH:	107570753 107583042 107584944 107591272

CCAR:

109045414 109049848 109063690 109111830

CAUA:

113046030 113047227 113047236 113066300 113099578

CGIB:

127946604 127949489 127953641 128013156

PTET:

122329800(map3k22) 122341269(map3k3)

LROH:

127155446(map3k22) 127156602(map3k3)

OMC:	131532913(map3k22) 131537410(map3k3)

PPRM:

120476029(map3k22) 120489484(map3k3)

RKG:	130072813(map3k3) 130083830(map3k22)

MAMB:

125257583(map3k22) 125276864(map3k3)

CIDE:

127505843 127509155

CERY:

137013498(map3k22) 137017581(map3k3)

MASI:

127432062 127434782 127450601 127451349

TROS:

130547029(map3k22) 130561833(map3k3)

TDW:	130413365(map3k22) 130426448(map3k3)

MANU:

129425922(map3k22) 129436086(map3k3)

IPU:	108256020 108256334(map3k22)

IFU:	128599682(map3k22) 128602865(map3k3)

PHYP:

113528353(map3k3) 113541066

SMEO:

124375590(map3k22) 124397000(map3k3)

TFD:	113652189(map3k3) 113660144(map3k22)

TVC:	132839958(map3k22) 132861545(map3k3)

TRN:	134301254(map3k22) 134336003(map3k3)

AMEX:

103034596(map3k3) 103044968(map3k22)

CMAO:

118798602(map3k22) 118821192(map3k3)

EEE:	113580221(map3k3) 113581205

CHAR:

105890180(map3k22) 105898540(map3k3)

TRU:	101061953 101072543(map3k3)

TFS:	130514273(map3k22) 130515228(map3k3)

TNG:	GSTEN00023918G001 GSTEN00027814G001

LCO:	104930222(map3k3) 104937092

NCC:	104943590(map3k3)

TBEN:

117492676(map3k3) 117495604(map3k22)

CGOB:

115025332

PGEO:

117451111(map3k3) 117465533(map3k22)

GACU:

117535848(map3k22) 117548727(map3k3)

EMAC:

134878281(map3k3) 134884081(map3k22)

ELY:	117264776(map3k22) 117268573(map3k3)

EFO:	125878923(map3k3) 125881649(map3k22)

PLEP:

121956486(map3k3) 121960467(map3k22)

SLUC:

116037923(map3k22) 116063928(map3k3)

ECRA:

117937594(map3k22) 117958168(map3k3)

ESP:	116672482 116703027(map3k3)

PFLV:

114548980 114569844(map3k3)

GAT:	120811919(map3k22) 120827375(map3k3)

PPUG:

119198728(map3k22) 119220774(map3k3)

AFB:	129098437(map3k3) 129110801(map3k22)

CLUM:

117734588(map3k3) 117749675(map3k22)

PSWI:

130188944(map3k3) 130205998(map3k22)

MSAM:

119893582(map3k3) 119910267(map3k22)

SCHU:

122866647(map3k22) 122869128(map3k3)

CUD:	121527233(map3k22) 121529500(map3k3)

ALAT:

119008591(map3k22) 119014200(map3k3)

MZE:	101468082(map3k3) 101475626

ONL:	100692691(map3k3) 100711264

OAU:	116309274(map3k3) 116314455(map3k22)

OLA:	101156127 101169290(map3k3)

OML:	112145989(map3k3) 112151453(map3k22)

CSAI:

133421768(map3k3) 133423099(map3k22)

XMA:	102228349 102234853(map3k3)

XCO:	114136809 114160172(map3k3)

XHE:	116711766 116735892(map3k3)

PRET:

103456566 103468920(map3k3)

PFOR:

103140402 103144993(map3k3)

PLAI:

106948891 106960611(map3k3)

PMEI:

106905053(map3k3) 106921034

GAF:	122821891(map3k3) 122824584(map3k22)

PPRL:

129364707(map3k22) 129373989(map3k3)

CVG:	107084751(map3k3) 107100967

CTUL:

119783389(map3k3) 119788998(map3k22)

GMU:	124858048(map3k22) 124863354 124864760

NFU:	107378534(map3k3) 107382822

KMR:	108230337(map3k22) 108237722(map3k3)

ALIM:

106513381 106534689(map3k3)

NWH:	119421229(map3k3) 119426395(map3k22)

AOCE:

111565972 111588903(map3k3)

MCEP:

124995666(map3k22) 124998192(map3k3)

CSEM:

103392663(map3k3)

POV:	109629552 109629839 109633995(map3k3)

SSEN:

122770611(map3k22) 122784976(map3k3)

HHIP:

117753812(map3k22) 117766821(map3k3)

HSP:	118098509(map3k22) 118123588(map3k3)

PPLT:

128425805(map3k22) 128458263(map3k3)

SMAU:

118288598(map3k3) 118290920(map3k22)

LCF:	108880564 108881705(map3k22)

SDU:	111217593(map3k3) 111221016

SLAL:

111656266 111660589(map3k3)

XGL:	120785035(map3k3) 120789697(map3k22)

HCQ:	109519483 109532434(map3k3)

SSCV:

125983722 125986082

SBIA:

133492821(map3k22) 133514879(map3k3)

PEE:	133396365(map3k22) 133415214(map3k3)

PTAO:

133466645(map3k3) 133470061(map3k22)

BPEC:

110160986 110167886(map3k3)

MALB:

109961492 109963171(map3k3)

BSPL:

114853752(map3k22) 114860371(map3k3)

SJO:	128379177(map3k3) 128382685(map3k22)

SASA:

106590696 106595351(map3k3) 106606859

STRU:

115171523 115195304 115203817

OTW:	112227444(map3k22) 112259007 121847262

OMY:	110486686 110538641 118938953(map3k22)

OGO:	124000403(map3k3) 124000568 124039431(map3k22)

ONE:	115110787 115110791

OKI:	109878689 109881914 109882222

OKE:	118374908(map3k3) 118377367 118382476

SALP:

111980991(map3k3) 112077065

SNH:	120034406 120044068

CCLU:

121549640 121556447 121568899 123482471 123491196

ELS:	105007693 105012974(map3k3)

SFM:	108918963 108927989 108937422

PKI:	111837634 111837851 111849744 111852859

AANG:

118220927(map3k3) 118225399(map3k22) 118233621

LOC:	102684228(map3k3) 102684734

PSPA:

121301869(map3k3) 121309866 121314031 121324895

ARUT:

117394816(map3k22) 117400396 117416421 117435074

PSEX:

120517514(map3k3) 120529593(map3k22)

LCM:	102350357 102353974(MAP3K3)

CMK:	103187711(map3k3) 103189852(map3k22)

RTP:	109913314(map3k22)

CPLA:

122540043(map3k3) 122548923(map3k22)

HOC:	132815069(map3k22) 132831031(map3k3)

LERI:

129710233(map3k3) 129715132

PMRN:

116948608

LRJ:

133349757

NAI:	NECAME_10109

BGT:	106072482 106080307

GAE:

MMER:

RPHI:

MAEA:

LJP:

ATEN:

XEN:

HMG:

HSY:

RES:	135681172 135692543

ATH:	AT1G53570(MAP3KA)

ALY:

9330509

CRB:

17898011

CSAT:

104742876 104758708 104778292

EUS:	EUTSA_v10022608mg

BRP:

103860382

BNA:	106389401 106439753

BOE:

106335806

RSZ:

108863113

THJ:	104807156 104819497

CPAP:

110816131 110818034

CIT:

102607672

CIC:	CICLE_v10000585mg

PVY:

116121481

MINC:

123199320

TCC:	18592500 18611858

GRA:	105762573 105779946 105797098

GHI:	107910418 107930871 107931203 107952027 107959477 107959605

GAB:	108458775 108475630 108476628

HSYR:

120118570 120131078 120146496 120147698 120165575 120199978

DZI:

111299762

EGR:

104415891

GMX:	100780004 100780263 100787064 100813122

GSJ:	114410093 114413225 114415780 114422014

PVU:	PHAVU_002G272100g PHAVU_009G150500g

VRA:	106773523 106780713

VAR:	108320414 108331635

VUN:	114162599 114177783

VUM:	124836865 124847476

CCAJ:

109799423 109807768

APRC:

113853597 113863686

MTR:	11425554 11436239

TPRA:

123913372 123914045

CAM:	101490408 101514482

PSAT:

127079711 127105135

VVO:	131602860 131638432 131661116

LJA:	130711957 130712915

ADU:

107480227

AIP:

107630938

AHF:	112715925 112733082 112782275 112791116

LANG:

109326749 109337627 109343408 109361470

PCIN:

129302601 129320293

QSA:	O6P43_030333

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103422673 103427113

MSYL:

126589008 126617425

PXB:	103938937 103960739

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

MEAN:

JCU:	105629174 105629578

HBR:	110651202 110661413 110662262

MESC:

110609539 110628225 110629945

POP:	7466732 7479138

PEU:	105124578 105130405

PALZ:

118032466 118040154

JRE:	108996281 109008901 109008902

CILL:

122303394 122307221

CAVE:

132165456

QSU:	111984336 111994181

QLO:	115959255 115963246

TWL:	120001739 120016845

VVI:

100243772

VRI:

117913566

SLY:	101243985 543918(MAPKKKalpha)

SPEN:

107004855 107018254

SOT:	102578443 107062289

SSTN:

125844997 125850530

SDUL:

129900703 129904227

CANN:

107850668 107867737

LBB:	132614984 132627225

NTA:	107760154 107765447 107799389 107821703

NSY:	104216818 104226881

NTO:	104116350 104116515

NAU:	109210228 109227015

INI:	109157540 109172719

ITR:	116012813 116013394 116021148

SIND:

105178081

OEU:	111367816 111397927 111401121 111410383

EGT:	105950093 105972633 105973230

SSPL:

SMIL:

SHIS:

APAN:

HAN:	110908419 110910535

ECAD:

122601950

LSV:	111880005 111894232

CCAV:

112511697

DCR:

108204080

CSIN:

114282277

RVL:	131303830 131335057

AEW:	130778269 130781230

BVG:

104895397

SOE:	110775554 110784504

CQI:	110681971 110695137

ATRI:

130820731 130823139

MOF:	131155902 131161911

NNU:	104599577 104606749

MING:

122071831 122074472

TSS:	122667763 122669323

OSA:	4329659 4335914 4350033

OBR:	102700618 102709411 102721244

OGL:	127754612 127763775 127772161

BDI:	100828104 100844114 100846068

ATS:	109750728 109758282

TDC:	119286437 119295336 119355208 119361473 119364336

TAES:

123042751 123045513 123053363 123086616 123091367 123096336 123189268 123191050

TUA:	125538344 125538475 125550885

LPER:

127294119 127334499 127334915

LRD:	124672819 124673793 124690139 124692386 124703553 124703555

SBI:	110435646 8064268 8075833

ZMA:	100191147 100191795 103627282

MFLO:

136467142 136473956 136483788 136483804 136486698 136486785 136490600

SITA:

101772243 101773692 101774927

SVS:	117833052 117856081 117863774

PVIR:

120641043 120644201 120656063 120668009 120681552 120684394 120699953 120704611

PHAI:

112886386 112895053 112899426 112902460

PDA:	103711039 103720517

EGU:	105038493 105051751

MUS:	103988068 103989096 103997449

ZOF:	121967995 121981534 121985411 122002657 122006906 122026600

DCT:	110098287 110112062

PEQ:	110021280 110024668

AOF:

MSIN:

NCOL:

ATR:

SMO:	SELMODRAFT_144969(MAP3KA3-1)

CME:	CYME_CMT185C

SLA:	SERLADRAFT_398861

SRE:	PTSG_00201 PTSG_13011

PTM:	GSPATT00015783001

GTT:	GUITHDRAFT_151185

» show all

Reference

PMID:18855897

Authors

Craig EA, Stevens MV, Vaillancourt RR, Camenisch TD

Title

MAP3Ks as central regulators of cell fate during development.

Journal

Dev Dyn 237:3102-14 (2008)
DOI:10.1002/dvdy.21750

Reference

PMID:9006902

Authors

Ellinger-Ziegelbauer H, Brown K, Kelly K, Siebenlist U

Title

Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative.

Journal

J Biol Chem 272:2668-74 (1997)
DOI:10.1074/jbc.272.5.2668

Sequence

[hsa:4215]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (10)   
   KEGG PATHWAY (10)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1723)   
   KEGG GENES (1001)   
   KEGG MGENES (245)   
   RefGene (463)   
   OC (14)   
Literature (2)   
   PubMed (2)   
All databases (1740)   

Download RDF

ORTHOLOGY: K04428

Entry

K04428                      KO

Symbol

MAP3K4, MEKK4

Name

mitogen-activated protein kinase kinase kinase 4 [EC:2.7.11.25]

Pathway

map04010

MAPK signaling pathway

map04013

MAPK signaling pathway - fly

map04624

Toll and Imd signaling pathway

map04912

GnRH signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04428  MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4
   04013 MAPK signaling pathway - fly
    K04428  MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4
09150 Organismal Systems
  09151 Immune system
   04624 Toll and Imd signaling pathway
    K04428  MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04428  MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04428  MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04428  MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4
Protein kinases [BR:ko01001]
Serine/threonine kinases: STE group
  STE11 family
   K04428  MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4

Other DBs

GO:

0004709

Genes

HSA:	4216(MAP3K4)

PTR:	463119(MAP3K4)

PPS:	100981441(MAP3K4)

GGO:	101152649(MAP3K4)

PON:	100442172(MAP3K4)

PPYG:

129038013(MAP3K4)

NLE:	100602313(MAP3K4)

HMH:	116473620(MAP3K4)

SSYN:

129476226(MAP3K4)

MCC:	710360(MAP3K4)

MCF:	101865276(MAP3K4)

MTHB:

126952364

MNI:	105487510(MAP3K4)

CSAB:

103240840(MAP3K4)

CATY:

105594238(MAP3K4)

PANU:

101009746(MAP3K4)

TGE:	112623312(MAP3K4)

MLEU:

105536526(MAP3K4)

RRO:	104669999(MAP3K4)

RBB:	108527990(MAP3K4)

TFN:	117096914(MAP3K4)

PTEH:

111550306(MAP3K4)

CANG:

105506725(MAP3K4)

CJC:	100413660(MAP3K4)

SBQ:	101042401(MAP3K4)

CIMI:

108310811(MAP3K4)

ANAN:

105716481(MAP3K4)

CSYR:

103262504(MAP3K4)

MMUR:

105868604(MAP3K4)

LCAT:

123633438(MAP3K4)

PCOQ:

105812407(MAP3K4)

OGA:	100949460(MAP3K4)

MMU:	26407(Map3k4)

MCAL:

110312545(Map3k4)

MPAH:

110338018(Map3k4)

RNO:	308106(Map3k4)

MCOC:

116079226(Map3k4)

ANU:	117700162(Map3k4)

MUN:	110554862(Map3k4)

CGE:	100764060(Map3k4)

MAUA:

101825628(Map3k4)

PROB:

127237739(Map3k4)

PLEU:

114691364(Map3k4)

MORG:

121466395(Map3k4)

MFOT:

126497713

AAMP:

119820823(Map3k4)

NGI:	103737023(Map3k4)

HGL:	101701961(Map3k4)

CPOC:

100724828(Map3k4)

CCAN:

109700149(Map3k4)

DORD:

105991838(Map3k4)

DSP:	122116096(Map3k4)

PLOP:

125357471(Map3k4)

NCAR:

124988149

MMMA:

107153105(Map3k4)

OCU:

100358104

OPI:	101517932(MAP3K4)

TUP:	102479582(MAP3K4)

GVR:	103592019(MAP3K4)

CFA:	476262(MAP3K4)

CLUD:

112643465(MAP3K4)

VVP:	112932971(MAP3K4)

VLG:	121484094(MAP3K4)

NPO:	129500244(MAP3K4)

AML:	100465667(MAP3K4)

UMR:	103660898(MAP3K4)

UAH:	113259629(MAP3K4)

UAR:	123797538(MAP3K4)

ELK:

111158665

LLV:

125102269

MPUF:

101689879(MAP3K4)

MNP:	132018446(MAP3K4)

MLK:	131833393(MAP3K4)

NVS:	122902766(MAP3K4)

ORO:	101379514(MAP3K4)

EJU:	114203524 114203526 114209226(MAP3K4)

ZCA:	113926391(MAP3K4)

MLX:	118001818 118001935

NSU:	110583163(MAP3K4)

LWW:	102743912(MAP3K4)

FCA:	101097977(MAP3K4)

PYU:	121013213(MAP3K4)

PCOO:

112862214(MAP3K4)

PBG:	122490157(MAP3K4)

PVIV:

125165221(MAP3K4)

LRUF:

124528221

PTG:	102952700(MAP3K4)

PPAD:

109245401(MAP3K4)

PUC:

125939033

AJU:

106985032

HHV:	120224269(MAP3K4)

BTA:	511779(MAP3K4)

BOM:	102283969(MAP3K4)

BIU:	109563601(MAP3K4)

BBUB:

102412509(MAP3K4)

BBIS:

104989266(MAP3K4)

CHX:	102172543(MAP3K4)

OAS:	101113246(MAP3K4)

BTAX:

128053073(MAP3K4)

ODA:	120862825(MAP3K4)

CCAD:

122434125(MAP3K4)

MBEZ:

129561294(MAP3K4)

SSC:	100154202(MAP3K4)

CFR:	102509815(MAP3K4)

CBAI:

105077460(MAP3K4)

CDK:	105086293(MAP3K4)

VPC:	102524979(MAP3K4)

BACU:

103006512(MAP3K4)

BMUS:

118905198(MAP3K4)

LVE:	103075844(MAP3K4)

OOR:	101277039(MAP3K4)

DLE:	111168464(MAP3K4)

PCAD:

102977794(MAP3K4)

PSIU:

116763745(MAP3K4)

NASI:

112401608(MAP3K4)

ECB:	100058153(MAP3K4)

EPZ:	103556184(MAP3K4)

EAI:	106842047(MAP3K4)

MYB:	102262729(MAP3K4)

MYD:	102757393(MAP3K4)

MMYO:

118659761(MAP3K4)

MLF:	102426152(MAP3K4)

MDT:	132236716(MAP3K4)

PKL:	118708850(MAP3K4)

EFUS:

103299827(MAP3K4)

MNA:	107535728(MAP3K4)

DRO:	112297294(MAP3K4)

SHON:

118995987(MAP3K4)

AJM:	119034988(MAP3K4)

PDIC:

114490085(MAP3K4)

PHAS:

123821571(MAP3K4)

MMF:	118621085(MAP3K4)

PPAM:

129088232(MAP3K4)

HAI:	109394013(MAP3K4)

RFQ:	117018595(MAP3K4)

PALE:

102888506(MAP3K4)

PGIG:

120618266(MAP3K4)

PVP:	105305679(MAP3K4)

RAY:	107514741(MAP3K4)

MJV:	108403112(MAP3K4)

TOD:	119251557(MAP3K4)

SARA:

101557576(MAP3K4)

SETR:

125996544(MAP3K4)

LAV:	100664871(MAP3K4)

TMU:

101342450

ETF:	101639947(MAP3K4)

DNM:	101435792(MAP3K4)

MDO:	100032495(MAP3K4)

GAS:	123243748(MAP3K4)

SHR:	100928208(MAP3K4)

AFZ:

127562393

PCW:	110208619(MAP3K4)

TVP:	118856730(MAP3K4)

OAA:	100081562(MAP3K4)

GGA:	421579(MAP3K4)

PCOC:

116242061(MAP3K4)

MGP:	100548383(MAP3K4)

CJO:	107311515(MAP3K4)

TPAI:

128080898(MAP3K4)

LMUT:

125688781(MAP3K4)

NMEL:

110395417(MAP3K4)

APLA:

101795899(MAP3K4)

ACYG:

106039514(MAP3K4)

CATA:

118243843(MAP3K4)

AFUL:

116487327(MAP3K4)

TGU:	100229845(MAP3K4)

LSR:	110477918(MAP3K4)

SCAN:

103821627(MAP3K4)

PMOA:

120506844(MAP3K4)

OTC:	121335758(MAP3K4)

PRUF:

121358675(MAP3K4)

GFR:	102043718(MAP3K4)

FAB:	101814940(MAP3K4)

OMA:	130250964(MAP3K4)

PHI:	102101107(MAP3K4)

PMAJ:

107201928(MAP3K4)

CCAE:

111926951(MAP3K4)

CCW:	104684463(MAP3K4)

CBRC:

103624194(MAP3K4)

ETL:	114055651(MAP3K4)

ZAB:	102074889(MAP3K4)

ZLE:	135445730(MAP3K4)

ACHL:

103812175(MAP3K4)

SVG:	106852970(MAP3K4)

MMEA:

130576007(MAP3K4)

HRT:	120750188(MAP3K4)

SATI:

136359321(MAP3K4)

FPG:	101918017(MAP3K4)

FCH:	102048037(MAP3K4)

CCRI:

104168452(MAP3K4)

NNT:	104412008(MAP3K4)

SHAB:

115613582(MAP3K4)

ACUN:

113477881(MAP3K4)

TALA:

104362499(MAP3K4)

ACHC:

115344333(MAP3K4)

HALD:

104316804(MAP3K4)

HLE:	104842256(MAP3K4)

AGEN:

126039044

GCL:

127014121

CSTI:

104560034(MAP3K4)

LDI:	104346909(MAP3K4)

MNB:	103779507(MAP3K4)

DPUB:

104307727(MAP3K4)

AVIT:

104271444(MAP3K4)

BRHI:

104496961(MAP3K4)

EGZ:	104124823(MAP3K4)

NNI:	104018435(MAP3K4)

PCRI:

104030508(MAP3K4)

PCAO:

104052344(MAP3K4)

PADL:

103914152(MAP3K4)

AFOR:

103907865(MAP3K4)

GSTE:

104260740

CLV:	102086486(MAP3K4)

MUI:	104540800(MAP3K4)

PLET:

104614048(MAP3K4)

EHS:	104511286(MAP3K4)

CMAC:

104479593(MAP3K4)

CUCA:

104056487(MAP3K4)

TEO:	104375638(MAP3K4)

BREG:

104636503(MAP3K4)

OHA:	104334710(MAP3K4)

ACAR:

104525390(MAP3K4)

CPEA:

104390820(MAP3K4)

CVF:	104295752(MAP3K4)

RTD:	128906529(MAP3K4)

AAM:	106486799(MAP3K4)

AROW:

112966410(MAP3K4)

NPD:	112951950(MAP3K4)

TGT:	104573398(MAP3K4)

DNE:	112988961(MAP3K4)

SCAM:

104152832(MAP3K4)

ASN:	102382136(MAP3K4)

AMJ:	102573918(MAP3K4)

CPOO:

109320062(MAP3K4)

GGN:	109304413(MAP3K4)

PSS:	102446659(MAP3K4)

CMY:	102936228(MAP3K4)

CCAY:

125633990(MAP3K4)

DCC:	119853138(MAP3K4)

CPIC:

101946795(MAP3K4)

TST:	117874783(MAP3K4)

CABI:

116832461(MAP3K4)

MRV:	120400708(MAP3K4)

ACS:	100560027(map3k4)

ASAO:

132761109(MAP3K4)

PVT:	110087352(MAP3K4)

SUND:

121929432(MAP3K4)

PBI:	103059578(MAP3K4)

PMUR:

107292071(MAP3K4)

CTIG:

120314787(MAP3K4)

TSR:	106549188(MAP3K4)

PGUT:

117672073(MAP3K4)

APRI:

131190807(MAP3K4)

PTEX:

113439289(MAP3K4)

NSS:	113417052(MAP3K4)

VKO:	123019057(MAP3K4)

PMUA:

114594310(MAP3K4)

PRAF:

128410722(MAP3K4)

ZVI:	118081954(MAP3K4)

HCG:	128344573(MAP3K4)

GJA:	107113333(MAP3K4)

STOW:

125428087(MAP3K4)

EMC:	129331745(MAP3K4)

XLA:	100126613(map3k4.S)

XTR:	100497217(map3k4)

NPR:	108795048(MAP3K4)

RTEM:

120937407(MAP3K4)

BBUF:

120998572(MAP3K4)

BGAR:

122936143(MAP3K4)

MUO:	115466686(MAP3K4)

GSH:	117357331(MAP3K4)

DRE:	325488(map3k4)

SRX:	107705416 107739870

SANH:

107654971 107679660

SGH:	107553172 107602945(map3k4)

CCAR:

109052888 109096081

CAUA:

113056767 113112502

CGIB:

127970638 128026046

PTET:

122356415 122356416(map3k4)

LROH:

127174736(map3k4)

OMC:	131551844(map3k4)

PPRM:

120467764(map3k4)

RKG:	130088279(map3k4)

MAMB:

125277165(map3k4)

CIDE:

127525563

CERY:

137020708(map3k4)

MASI:

127412023 127413879

TROS:

130558827(map3k4)

TDW:	130431293(map3k4)

MANU:

129415527(map3k4)

IPU:

108260840

IFU:	128604520(map3k4)

PHYP:

113544293(map3k4)

SMEO:

124381434(map3k4)

TFD:	113660711(map3k4)

TVC:	132841855(map3k4)

TRN:	134326873(map3k4)

AMEX:

103046281(map3k4)

CMAO:

118816782(map3k4)

EEE:	113581424(map3k4)

CHAR:

105890949(map3k4)

TRU:	101076799 115246474

TFS:	130533310(map3k4)

TNG:	GSTEN00030726G001

LCO:	104940016(map3k4)

NCC:	104953033(map3k4)

TBEN:

117499637(map3k4)

CGOB:

115019839(map3k4)

PGEO:

117459814(map3k4)

GACU:

117536847(map3k4)

EMAC:

134859124(map3k4)

ELY:	117248444(map3k4)

EFO:	125903596(map3k4)

PLEP:

121954529(map3k4)

SLUC:

116052359(map3k4)

ECRA:

117960393(map3k4)

ESP:	116704886(map3k4)

PFLV:

114572027(map3k4)

GAT:	120820425(map3k4)

PPUG:

119214154(map3k4)

AFB:	129092174(map3k4)

CLUM:

117744339(map3k4)

PSWI:

130206842(map3k4)

MSAM:

119917295(map3k4)

SCHU:

122884672(map3k4)

CUD:	121511085(map3k4)

ALAT:

119033400(map3k4)

MZE:	101485830(map3k4)

ONL:	100701169(map3k4)

OAU:	116322740(map3k4)

OLA:	101174856(map3k4)

OML:	112161704(map3k4)

CSAI:

133463327(map3k4)

XMA:	102230475(map3k4)

XCO:	114137786(map3k4)

XHE:	116713097(map3k4)

PRET:

103477032(map3k4)

PFOR:

103134094(map3k4)

PLAI:

106951872(map3k4)

PMEI:

106915515(map3k4)

GAF:	122842183(map3k4)

PPRL:

129359801(map3k4)

CVG:	107103016(map3k4)

CTUL:

119790714(map3k4)

GMU:	124859256(map3k4)

NFU:	107373664(map3k4)

KMR:	108234108(map3k4)

ALIM:

106518124(map3k4)

NWH:	119417946(map3k4)

AOCE:

111562975(map3k4)

MCEP:

125019058(map3k4)

CSEM:

103387276(map3k4)

POV:	109634498(map3k4)

SSEN:

122781920(map3k4)

HHIP:

117775425(map3k4)

HSP:	118119073(map3k4)

PPLT:

128453652(map3k4)

SMAU:

118283612(map3k4)

LCF:

108894538

SDU:	111234458(map3k4)

SLAL:

111658959(map3k4)

XGL:	120796389(map3k4)

HCQ:	109516250(map3k4)

SSCV:

125978745

SBIA:

133509601(map3k4)

PEE:	133409822(map3k4)

PTAO:

133485895(map3k4)

BPEC:

110157029(map3k4)

MALB:

109961895(map3k4)

BSPL:

114870830(map3k4)

SJO:	128372778(map3k4)

SASA:

106589750 106611248

STRU:

115152798(map3k4) 115200875

OTW:	112224608 112236421

OMY:	110499330 110503014

OGO:	124038652 124040324

ONE:	115118837 115144388

OKI:	109870569 109882110

OKE:	118396657 118402794

SALP:

111968073 112070316

SNH:	120029587(map3k4) 120041312

CCLU:

121540796 121554627

ELS:	105008100(map3k4)

SFM:	108942741(map3k4)

PKI:	111853413(map3k4)

AANG:

118217895(map3k4)

LOC:	102685764(map3k4)

PSPA:

121316302(map3k4) 121316717

ARUT:

117402821(map3k4) 117411192

PSEX:

120516902(map3k4)

LCM:	102366133(MAP3K4)

CMK:	103175928(map3k4)

RTP:	109926885(map3k4)

CPLA:

122552974(map3k4)

HOC:	132819825(map3k4)

LERI:

129699539(map3k4)

PMRN:

116955477

LRJ:	133356999(MAP3K4)

CIN:

SCLV:

SPU:

APLC:

ARUN:

DME:	Dmel_CG7717(Mekk1)

DER:

6553864

DSE:

6613723

DSI:	Dsimw501_GD20154(Dsim_GD20154)

DYA:	Dyak_GE25175

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI21956

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ001610

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105671571(Mekk1)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_213875

BANY:

PXU:

PRAP:

ZCE:

AAGE:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

LGLY:

CCRN:

API:

DNX:

AGS:

RMD:

BTAB:

DCI:

CLEC:

HHAL:

106680931(Mekk1)

NLU:

HVI:

MQU:

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

DPX:	DAPPUDRAFT_233822

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:

MNZ:	135205419 135205420

HAZT:

EAF:

LSM:

TCF:

PPOI:

CVS:	136979857(Mekk1)

PMEO:

129587860

CEL:	CELE_B0414.7(mtk-1)

CBR:	CBG_04061(Cbr-mtk-1)

CRQ:	GCK72_001010

BMY:	BM_BM6488(Bma-mtk-1)

LOA:	LOAG_05861

LGI:	LOTGIDRAFT_168212

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:	105334041 105339386 117691552 117692324

CANU:

CVN:

OED:

MYI:

PMAX:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:	5501414 5508320

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HSY:

RES:

AQU:

Reference

PMID:9079650

Authors

Gerwins P, Blank JL, Johnson GL

Title

Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway.

Journal

J Biol Chem 272:8288-95 (1997)
DOI:10.1074/jbc.272.13.8288

Sequence

[mmu:26407]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (8)   
   KEGG PATHWAY (8)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2233)   
   KEGG GENES (642)   
   KEGG MGENES (507)   
   RefGene (1078)   
   OC (6)   
Literature (1)   
   PubMed (1)   
All databases (2247)   

Download RDF

ORTHOLOGY: K04420

Entry

K04420                      KO

Symbol

MAP3K2, MEKK2

Name

mitogen-activated protein kinase kinase kinase 2 [EC:2.7.11.25]

Pathway

map04010

MAPK signaling pathway

map04540

Gap junction

map04912

GnRH signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04420  MAP3K2, MEKK2; mitogen-activated protein kinase kinase kinase 2
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K04420  MAP3K2, MEKK2; mitogen-activated protein kinase kinase kinase 2
09150 Organismal Systems
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04420  MAP3K2, MEKK2; mitogen-activated protein kinase kinase kinase 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04420  MAP3K2, MEKK2; mitogen-activated protein kinase kinase kinase 2
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04420  MAP3K2, MEKK2; mitogen-activated protein kinase kinase kinase 2
Protein kinases [BR:ko01001]
Serine/threonine kinases: STE group
  STE11 family
   K04420  MAP3K2, MEKK2; mitogen-activated protein kinase kinase kinase 2

Other DBs

GO:

0004709

Genes

HSA:	10746(MAP3K2)

PTR:	736244(MAP3K2)

PPS:	100973371(MAP3K2)

GGO:	101149805(MAP3K2)

PON:	100450054(MAP3K2)

PPYG:

129031191(MAP3K2)

NLE:	100601802(MAP3K2)

HMH:	116462992(MAP3K2)

SSYN:

129472461(MAP3K2)

MCC:	100424131(MAP3K2)

MCF:	102138136(MAP3K2)

MTHB:

126933061

MNI:	105492428(MAP3K2)

CSAB:

103216879(MAP3K2)

CATY:

105592087(MAP3K2)

PANU:

101009475(MAP3K2)

TGE:	112635784(MAP3K2)

MLEU:

105539998(MAP3K2)

RRO:	104662431(MAP3K2)

RBB:	108533000(MAP3K2)

TFN:	117095159(MAP3K2)

PTEH:

111551574(MAP3K2)

CANG:

105511521(MAP3K2)

CJC:	100406711(MAP3K2)

SBQ:	101035799(MAP3K2)

CIMI:

108317750(MAP3K2)

ANAN:

105724011(MAP3K2)

CSYR:

103276598(MAP3K2)

MMUR:

105857534(MAP3K2)

LCAT:

123643354(MAP3K2)

PCOQ:

105814842(MAP3K2)

OGA:	100959913(MAP3K2)

MMU:	26405(Map3k2)

MCAL:

110284747(Map3k2)

MPAH:

110333106(Map3k2)

RNO:	171492(Map3k2)

MCOC:

116086949(Map3k2)

ANU:	117719731(Map3k2)

MUN:	110553443(Map3k2)

CGE:	100772559(Map3k2)

MAUA:

101841854(Map3k2)

PROB:

127235127(Map3k2)

PLEU:

114691643(Map3k2)

MORG:

121445789 121453706(Map3k2)

MFOT:

126497096

AAMP:

119814348(Map3k2)

NGI:	103732132(Map3k2)

HGL:	101726195(Map3k2)

CPOC:

100723690(Map3k2)

CCAN:

109699113(Map3k2)

DORD:

105988946(Map3k2)

DSP:	122112321(Map3k2)

PLOP:

125350813(Map3k2)

NCAR:

124979813

MMMA:

107136789(Map3k2)

OCU:

100355693

OPI:	101520350(MAP3K2)

TUP:	102485186(MAP3K2)

GVR:	103591821(MAP3K2)

CFA:	612902(MAP3K2)

CLUD:

112652434(MAP3K2)

VVP:	112932690(MAP3K2)

VLG:	121481972(MAP3K2)

NPO:	129503742(MAP3K2)

AML:	100475426(MAP3K2)

UMR:	103658571(MAP3K2)

UAH:	113263482(MAP3K2)

UAR:	123779518(MAP3K2)

ELK:

111160868

LLV:

125096067

MPUF:

101680578(MAP3K2)

MNP:	132013979(MAP3K2)

MLK:	131826895(MAP3K2)

NVS:	122902757(MAP3K2)

ORO:	101368270(MAP3K2)

EJU:	114207235(MAP3K2)

ZCA:	113919414(MAP3K2)

MLX:	118012568(MAP3K2)

NSU:	110585725(MAP3K2)

LWW:	102728069(MAP3K2)

FCA:	101096406(MAP3K2)

PYU:	121030401(MAP3K2)

PCOO:

112865537(MAP3K2)

PBG:	122481226(MAP3K2)

PVIV:

125172033(MAP3K2)

LRUF:

124514585

PTG:	102957925(MAP3K2)

PPAD:

109278797(MAP3K2)

PUC:

125911703

AJU:

106966378

HHV:	120245944(MAP3K2)

BTA:	504592(MAP3K2)

BOM:	102273125(MAP3K2)

BIU:	109565311(MAP3K2)

BBUB:

102406531(MAP3K2)

BBIS:

105005036(MAP3K2)

CHX:	102175623(MAP3K2)

OAS:	101109858(MAP3K2)

BTAX:

128071523(MAP3K2)

ODA:	120854033(MAP3K2)

CCAD:

122453931(MAP3K2)

MBEZ:

129538502(MAP3K2)

SSC:	100621234(MAP3K2)

CFR:	102505073(MAP3K2)

CBAI:

105068597(MAP3K2)

CDK:	105084487(MAP3K2)

VPC:	102530654(MAP3K2)

BACU:

103017845(MAP3K2)

BMUS:

118897825(MAP3K2)

LVE:	103083140(MAP3K2)

OOR:	101270305(MAP3K2)

DLE:	111183352(MAP3K2)

PCAD:

102985391(MAP3K2)

PSIU:

116756540(MAP3K2)

NASI:

112394996(MAP3K2)

ECB:	100050628(MAP3K2)

EPZ:	103562194(MAP3K2)

EAI:	106834092(MAP3K2)

MYB:	102245865(MAP3K2)

MYD:	102753581(MAP3K2)

MMYO:

118661831(MAP3K2)

MLF:	102421812(MAP3K2)

MDT:	132238737(MAP3K2)

PKL:	118708818(MAP3K2)

EFUS:

103301216(MAP3K2)

MNA:	107528582(MAP3K2)

DRO:	112313010(MAP3K2)

AJM:	119045211(MAP3K2)

PDIC:

114494679(MAP3K2)

PHAS:

123810283(MAP3K2)

MMF:	118625228(MAP3K2)

PPAM:

129071749(MAP3K2)

HAI:	109371823(MAP3K2)

RFQ:	117020093(MAP3K2)

PALE:

102880422(MAP3K2)

PGIG:

120593428(MAP3K2)

PVP:	105294444(MAP3K2)

RAY:	107516884(MAP3K2)

MJV:	108400895(MAP3K2)

TOD:	119255707(MAP3K2)

SARA:

101544873(MAP3K2)

SETR:

126008841(MAP3K2)

LAV:	100665139(MAP3K2)

TMU:

101349577

ETF:	101647418(MAP3K2)

DNM:	101441585(MAP3K2)

MDO:	100026735(MAP3K2)

GAS:	123242307(MAP3K2)

SHR:	100916713(MAP3K2)

AFZ:

127554294

PCW:	110194666(MAP3K2)

TVP:	118838321(MAP3K2)

OAA:	100087843(MAP3K2)

GGA:	424225(MAP3K2)

PCOC:

116227346(MAP3K2)

MGP:	100543830(MAP3K2)

CJO:	107316800(MAP3K2)

TPAI:

128076663(MAP3K2)

LMUT:

125697180(MAP3K2)

NMEL:

110399799(MAP3K2)

APLA:

101798043(MAP3K2)

ACYG:

106045922(MAP3K2)

CATA:

118259964(MAP3K2)

AFUL:

116490728(MAP3K2)

TGU:	100219827(MAP3K2) 116808715

LSR:	110468326(MAP3K2)

SCAN:

103814336(MAP3K2)

PMOA:

120508525(MAP3K2)

OTC:	121337177(MAP3K2)

PRUF:

121356542(MAP3K2)

GFR:	102033648(MAP3K2)

FAB:	101811653(MAP3K2)

OMA:	130255601(MAP3K2)

PHI:	102113050(MAP3K2)

PMAJ:

107207590(MAP3K2)

CCAE:

111932210(MAP3K2)

CCW:	104693990(MAP3K2)

CBRC:

103625418(MAP3K2)

ETL:	114055550(MAP3K2)

ZAB:	102062111(MAP3K2)

ZLE:	135450129(MAP3K2)

ACHL:

103810253(MAP3K2)

SVG:	106861393(MAP3K2)

MMEA:

130572822(MAP3K2)

HRT:	120755028(MAP3K2)

SATI:

136363630(MAP3K2)

FPG:	101921462(MAP3K2)

FCH:	102052668(MAP3K2)

CCRI:

104162623(MAP3K2)

NNT:	104400882(MAP3K2)

SHAB:

115607962(MAP3K2)

ACUN:

113482266(MAP3K2)

TALA:

104364725(MAP3K2)

ACHC:

115342457(MAP3K2)

HALD:

104325911(MAP3K2)

HLE:	104832345(MAP3K2)

AGEN:

126037983

GCL:

127018205

CSTI:

104555134(MAP3K2)

LDI:	104349527(MAP3K2)

MNB:	103768947(MAP3K2)

DPUB:

104309758(MAP3K2)

AVIT:

104275935(MAP3K2)

BRHI:

104494824(MAP3K2)

EGZ:	104133722(MAP3K2)

NNI:	104018989(MAP3K2)

PCRI:

104031282(MAP3K2)

PCAO:

104040558(MAP3K2)

PADL:

103916532(MAP3K2)

AFOR:

103895391(MAP3K2)

FGA:	104071445(MAP3K2)

GSTE:

104251916(MAP3K2)

CLV:	102092494(MAP3K2)

MUI:	104535681(MAP3K2)

PGUU:

104467138(MAP3K2)

PLET:

104613902(MAP3K2)

EHS:	104511742(MAP3K2)

CMAC:

104479327(MAP3K2)

CUCA:

104056213(MAP3K2)

TEO:	104379869(MAP3K2)

BREG:

104630430(MAP3K2)

OHA:	104335225(MAP3K2)

ACAR:

104519825(MAP3K2)

CPEA:

104387320(MAP3K2)

CVF:	104288477(MAP3K2)

RTD:	128913043(MAP3K2)

AAM:	106499278(MAP3K2)

AROW:

112972018(MAP3K2)

NPD:	112950071(MAP3K2)

TGT:	104568405(MAP3K2)

DNE:	112980569(MAP3K2)

SCAM:

104139599(MAP3K2)

ASN:	102379289 102381161

AMJ:	102574412(MAP3K2)

CPOO:

109322513 109322639

GGN:	109301455 109301576

PSS:	102448094(MAP3K2)

CMY:	102941356(MAP3K2)

CCAY:

125644755(MAP3K2)

DCC:	119863684(MAP3K2)

CPIC:

101934711(MAP3K2)

TST:	117884687(MAP3K2)

CABI:

116828386(MAP3K2)

MRV:	120374714(MAP3K2)

ACS:	100558170(map3k2)

ASAO:

132774169(MAP3K2)

PVT:	110085271(MAP3K2)

SUND:

121919144(MAP3K2)

PBI:	103049938(MAP3K2)

PMUR:

107302054(MAP3K2)

CTIG:

120298299(MAP3K2)

TSR:	106548568(MAP3K2)

PGUT:

117668232(MAP3K2)

APRI:

131204514(MAP3K2)

PTEX:

113441211(MAP3K2)

NSS:	113410690(MAP3K2)

VKO:	123027569(MAP3K2)

PMUA:

114603537(MAP3K2)

PRAF:

128420767(MAP3K2)

ZVI:	118091365(MAP3K2)

HCG:	128345545(MAP3K2)

GJA:	107117807(MAP3K2)

STOW:

125425883(MAP3K2)

EMC:	129323747(MAP3K2)

XLA:	108701261(map3k2.L) 108702901(map3k2.S)

XTR:	100493570(map3k2)

NPR:	108785393(MAP3K2)

RTEM:

120944245(MAP3K2)

BBUF:

121008685(MAP3K2)

BGAR:

122923875(MAP3K2)

MUO:	115474821(MAP3K2)

DRE:	558321(map3k2)

SRX:	107705487 107706666

SANH:

107660022 107677576

SGH:	107581346 107584801

CCAR:

109057196(map3k2) 109089690

CAUA:

113050870 113092298

CGIB:

127959585 128016158

PTET:

122346889(map3k2)

LROH:

127166627(map3k2)

OMC:	131542360(map3k2)

PPRM:

120491364(map3k2)

RKG:	130101312(map3k2)

MAMB:

125274238(map3k2)

CIDE:

127514127

CERY:

137011744(map3k2)

MASI:

127446267 127448770

TROS:

130556647(map3k2)

TDW:	130424759(map3k2)

MANU:

129451169(map3k2)

IPU:

108272715

IFU:	128615724(map3k2)

PHYP:

113538380(map3k2)

SMEO:

124390226(map3k2)

TFD:	113651071(map3k2)

TVC:	132844940(map3k2)

TRN:	134316512(map3k2)

AMEX:

103026704(map3k2)

CMAO:

118807844(map3k2)

EEE:	113584100(map3k2)

TRU:	101069746(map3k2)

TFS:	130522343(map3k2)

TNG:	GSTEN00003091G001 GSTEN00031843G001

LCO:	104934606(map3k2)

TBEN:

117499194(map3k2)

CGOB:

115017317

PGEO:

117440886

EMAC:

134860973(map3k2)

ELY:	117249877(map3k2)

EFO:	125884821(map3k2)

PLEP:

121962696(map3k2)

SLUC:

116044770(map3k2)

ECRA:

117939603(map3k2)

ESP:	116673862(map3k2)

PFLV:

114550986(map3k2)

GAT:	120821828(map3k2)

PPUG:

119220166(map3k2)

AFB:	129111508(map3k2)

CLUM:

117741848(map3k2)

PSWI:

130204412(map3k2)

MSAM:

119900363(map3k2)

SCHU:

122871834(map3k2)

CUD:	121506159(map3k2)

ALAT:

119015229(map3k2)

MZE:	101464541(map3k2)

ONL:	100705497(map3k2)

OAU:	116317140(map3k2)

OLA:	101160297(map3k2)

OML:	112156757(map3k2)

CSAI:

133425187(map3k2)

XMA:	102232571(map3k2)

XCO:	114140552(map3k2)

XHE:	116715804(map3k2)

PRET:

103457092(map3k2)

PFOR:

103154108

PLAI:

106949502

PMEI:

106919573(map3k2)

GAF:	122826942(map3k2)

PPRL:

129356975(map3k2)

CVG:	107103639(map3k2)

CTUL:

119794653(map3k2)

GMU:	124861929(map3k2)

NFU:	107384647(map3k2)

KMR:	108246834(map3k2)

ALIM:

106531440(map3k2)

NWH:	119428919(map3k2)

AOCE:

111562626(map3k2)

MCEP:

125000989(map3k2)

CSEM:

103389509(map3k2)

POV:	109640231(map3k2)

SSEN:

122764665(map3k2)

HHIP:

117778062(map3k2)

HSP:	118103322(map3k2)

PPLT:

128430817(map3k2)

SMAU:

118317047(map3k2)

LCF:

108873167

SDU:	111222725(map3k2)

SLAL:

111672426(map3k2)

XGL:	120798063(map3k2)

HCQ:	109520183(map3k2)

SSCV:

125987743

SBIA:

133505770(map3k2)

PEE:	133402519(map3k2)

PTAO:

133478744(map3k2)

BPEC:

110165688(map3k2)

MALB:

109955649(map3k2)

BSPL:

114845767(map3k2)

SJO:	128354521(map3k2)

SASA:

106574243 106575171

STRU:

115179118 115196032

OTW:	112253822 112266510

OMY:	110495870 110527482

OGO:	124008084 124010861

ONE:	115129705 115133479

OKI:	109878173 109906717

OKE:	118363754 118370219

SALP:

111953393 111971080

SNH:	120033319 120051283

CCLU:

121540883(map3k2)

ELS:	105019952(map3k2)

SFM:	108920647(map3k2)

PKI:	111840805(map3k2)

AANG:

118214016(map3k2)

LOC:	102696072(map3k2)

PSPA:

121322029

ARUT:

117409171(map3k2) 117414908

PSEX:

120531266(map3k2)

LCM:	102350566(MAP3K2)

CMK:	103189809(map3k2)

CPLA:

122551845(map3k2)

HOC:	132817695(map3k2)

LERI:

129695189(map3k2)

PMRN:

LRJ:

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

ARUN:

AJC:

SKO:

BMY:	BM_BM5676(Bm5676)

LOA:	LOAG_05805

LGI:	LOTGIDRAFT_139776

PVUL:

126807869

PCAN:

112574465

BGT:	106060316 106068194 106075259

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MCAF:

DPOL:

OBI:

OSN:

LAK:

LLON:

NVE:	116609751 116619341 5513186

EPA:	110240989 110253938

ATEN:

116292986

ADF:

107347933

AMIL:

114948103 114970263

PDAM:

113665784 113672621 113682181

SPIS:

111327565 111330209 111337057 111341664

DGT:	114525673 114542461

HSY:

130641830

TAD:	TRIADDRAFT_22456

AQU:

100632568

SLY:	101263809 101264176

SPEN:

107011869 107015984

SOT:	102583428 102594279 102600645

SSTN:

125848269 125855456

SDUL:

129873982 129902968

CANN:

107853292 107867121

LBB:	132622602 132627912

NTA:	107759622 107794142 107798149 107802508 107805689

NSY:	104210273 104236972

NTO:	104094695 104095169 104105448

NAU:	109217874 109224935 109225188

SIND:

SSPL:

SMIL:

SHIS:

HAN:

LSV:

CCAV:

CSIN:

RVL:

MBR:	MONBRDRAFT_1800

JAG:

GJA_3447

» show all

Reference

PMID:18855897

Authors

Craig EA, Stevens MV, Vaillancourt RR, Camenisch TD

Title

MAP3Ks as central regulators of cell fate during development.

Journal

Dev Dyn 237:3102-14 (2008)
DOI:10.1002/dvdy.21750

All links

Ontology (4)   
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Pathway (6)   
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Chemical reaction (1)   
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Gene (1030)   
   KEGG GENES (513)   
   KEGG MGENES (210)   
   RefGene (298)   
   OC (9)   
Literature (1)   
   PubMed (1)   
All databases (1042)   

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