KEGG ORTHOLOGY: K04426

ORTHOLOGY: K04426

Entry

K04426                      KO

Symbol

MAP3K5, ASK1

Name

mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]

Pathway

map01524

Platinum drug resistance

map04010

MAPK signaling pathway

map04013

MAPK signaling pathway - fly

map04071

Sphingolipid signaling pathway

map04141

Protein processing in endoplasmic reticulum

map04210

Apoptosis

map04214

Apoptosis - fly

map04530

Tight junction

map04668

TNF signaling pathway

map04714

Thermogenesis

map04722

Neurotrophin signaling pathway

map04932

Non-alcoholic fatty liver disease

map04936

Alcoholic liver disease

map05010

Alzheimer disease

map05012

Parkinson disease

map05014

Amyotrophic lateral sclerosis

map05016

Huntington disease

map05017

Spinocerebellar ataxia

map05022

Pathways of neurodegeneration - multiple diseases

map05208

Chemical carcinogenesis - reactive oxygen species

map05417

Lipid and atherosclerosis

map05418

Fluid shear stress and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   04013 MAPK signaling pathway - fly
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   04668 TNF signaling pathway
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   04071 Sphingolipid signaling pathway
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   04214 Apoptosis - fly
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  09159 Environmental adaptation
   04714 Thermogenesis
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   05012 Parkinson disease
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   05014 Amyotrophic lateral sclerosis
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   05016 Huntington disease
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   05017 Spinocerebellar ataxia
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   05022 Pathways of neurodegeneration - multiple diseases
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   05418 Fluid shear stress and atherosclerosis
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   04932 Non-alcoholic fatty liver disease
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
Protein kinases [BR:ko01001]
Serine/threonine kinases: STE group
  STE11 family
   K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5

Other DBs

GO:

0004709

Genes

HSA:	4217(MAP3K5)

PTR:	463023(MAP3K5)

PPS:	100991014(MAP3K5)

GGO:	101147354(MAP3K5)

PON:	100458776(MAP3K5)

NLE:	100587332(MAP3K5)

MCC:	711382(MAP3K5)

MCF:	101925657(MAP3K5)

CSAB:

103240310(MAP3K5)

CATY:

105600400(MAP3K5)

PANU:

101002917(MAP3K5)

TGE:	112623422(MAP3K5)

RRO:	104675014(MAP3K5)

RBB:	108522968(MAP3K5)

TFN:	117097478(MAP3K5)

PTEH:

111525521(MAP3K5)

CJC:	100406322(MAP3K5)

SBQ:	101034123(MAP3K5)

CSYR:

103256327(MAP3K5)

MMUR:

105857227(MAP3K5)

OGA:	100943232(MAP3K5)

MMU:	26408(Map3k5)

MCAL:

110303338(Map3k5)

MPAH:

110337870(Map3k5)

RNO:	365057(Map3k5)

MCOC:

116097922(Map3k5)

CGE:	100752376(Map3k5)

NGI:	103724902(Map3k5)

HGL:	101712051(Map3k5)

CPOC:

100722979(Map3k5)

CCAN:

109697041(Map3k5)

DORD:

105993516(Map3k5)

DSP:	122126135(Map3k5)

OCU:	100340498(MAP3K5)

OPI:	101530376(MAP3K5)

TUP:	102495244(MAP3K5)

CFA:	476215(MAP3K5)

VVP:	112919386(MAP3K5)

VLG:	121481859(MAP3K5)

AML:	100475304(MAP3K5)

UMR:	103663496(MAP3K5)

UAH:	113259481(MAP3K5)

UAR:	123803353(MAP3K5)

ELK:

111147502

LLV:

125103005

MPUF:

101686402(MAP3K5)

ORO:	101374728(MAP3K5)

EJU:	114222735(MAP3K5)

ZCA:	113927218(MAP3K5)

MLX:	118000829(MAP3K5)

FCA:	101082912(MAP3K5)

PYU:	121013412(MAP3K5)

PBG:	122490389(MAP3K5)

PTG:	102960317(MAP3K5)

PPAD:

109249879(MAP3K5)

AJU:	106983673(MAP3K5)

HHV:	120222015 120239371

BTA:	537380(MAP3K5)

BOM:	102276849(MAP3K5)

BIU:	109563980(MAP3K5)

BBUB:

102408502(MAP3K5)

CHX:	102172156(MAP3K5)

OAS:	101121018(MAP3K5)

ODA:	120863070(MAP3K5)

CCAD:

122433913(MAP3K5)

SSC:	100622769(MAP3K5)

CFR:	102522243(MAP3K5)

CBAI:

105077264(MAP3K5)

CDK:	105092037(MAP3K5)

VPC:	102544996(MAP3K5)

BACU:

102999328(MAP3K5)

OOR:	101277232(MAP3K5)

DLE:	111166150(MAP3K5)

PCAD:

102976909(MAP3K5)

PSIU:

116763459(MAP3K5)

ECB:	100073186(MAP3K5)

EPZ:	103556363(MAP3K5)

EAI:	106837192(MAP3K5)

MYB:	102256847(MAP3K5)

MYD:	102771311(MAP3K5)

MMYO:

118659758(MAP3K5)

MLF:	102439932(MAP3K5)

MNA:	107530984(MAP3K5)

PKL:	118705482(MAP3K5)

HAI:	109385622(MAP3K5)

DRO:	112297079(MAP3K5)

SHON:

118986673(MAP3K5)

AJM:

119052787

PDIC:

114494013(MAP3K5)

PHAS:

123821582(MAP3K5)

MMF:	118620900(MAP3K5)

RFQ:	117020789(MAP3K5)

PALE:

102888994(MAP3K5)

PGIG:

120615779(MAP3K5)

PVP:	105289473(MAP3K5)

RAY:	107521291(MAP3K5)

MJV:	108401094(MAP3K5)

TOD:	119252904(MAP3K5)

SARA:

101547499(MAP3K5)

LAV:	100658813(MAP3K5)

TMU:

101346612

DNM:	101411083(MAP3K5)

MDO:	100031527(MAP3K5)

GAS:	123247967(MAP3K5)

SHR:	100917439(MAP3K5)

PCW:	110208922(MAP3K5)

OAA:	100081079(MAP3K5)

GGA:	421688(MAP3K5)

PCOC:

116240569(MAP3K5)

CJO:	107311662(MAP3K5)

NMEL:

110395802(MAP3K5)

APLA:

101799109(MAP3K5)

ACYG:

106032515(MAP3K5)

AFUL:

116487197(MAP3K5)

TGU:	100224192(MAP3K5)

LSR:	110483316(MAP3K5)

SCAN:

103818465(MAP3K5)

PMOA:

120501237(MAP3K5)

OTC:	121346192(MAP3K5)

PRUF:

121354869(MAP3K5)

GFR:	102034507(MAP3K5)

FAB:	101813811(MAP3K5)

PHI:	102104081(MAP3K5)

PMAJ:

107201551(MAP3K5)

CCAE:

111926799(MAP3K5)

CCW:	104689448(MAP3K5)

ETL:	114059498(MAP3K5)

ZAB:	102060991(MAP3K5)

FPG:	101911552(MAP3K5)

FCH:	102057038(MAP3K5)

CLV:	102085051(MAP3K5)

EGZ:	104131143(MAP3K5)

NNI:	104008816(MAP3K5)

ACUN:

113478110(MAP3K5)

TALA:

104366747(MAP3K5)

PADL:

103912745(MAP3K5)

ACHC:

115344983(MAP3K5)

AAM:	106497979(MAP3K5)

AROW:

112977195(MAP3K5)

NPD:	112954904(MAP3K5)

DNE:	112996005(MAP3K5)

ASN:	102375722(MAP3K5)

AMJ:	102573024(MAP3K5)

CPOO:

109320192(MAP3K5)

GGN:	109304590(MAP3K5)

PSS:	102451227(MAP3K5)

CMY:	102936034(MAP3K5)

CPIC:

101943963(MAP3K5)

TST:	117874903(MAP3K5)

CABI:

116818836(MAP3K5)

MRV:	120402164(MAP3K5)

ACS:	100551616(map3k5)

PVT:	110071741(MAP3K5)

SUND:

121932476(MAP3K5)

PBI:	103052010(MAP3K5)

PMUR:

107282238(MAP3K5)

TSR:	106554087(MAP3K5)

PGUT:

117666295(MAP3K5)

VKO:	123020316(MAP3K5) 123026039(MAP3K6)

PMUA:

114594175(MAP3K5)

ZVI:	118082069(MAP3K5)

GJA:

107117647

XLA:

108717885

XTR:	100497692(map3k5)

NPR:	108787404(MAP3K5)

RTEM:

120937349(MAP3K5)

BBUF:

120998524(MAP3K5)

BGAR:

122934291(MAP3K5)

DRE:	100005496(si:ch211-1i11.3) 555703(map3k5)

SRX:	107705646 107740525(map3k5) 107755537

SANH:

107653159 107660504 107700717 107704978

SGH:	107554152 107556089 107570516 107588497

CCAR:

109048836 109092120

CAUA:

113037674 113063497 113115999

IPU:	108257027(map3k5) 108268173(si:ch211-1i11.3) 108271733

PHYP:

113526624 113528943(map3k5)

SMEO:

124384976(si:ch211-1i11.3) 124401148(map3k5)

AMEX:

103033000(map3k5) 103038360

EEE:	113572229 113589755(map3k5)

TRU:	101061432(map3k5) 101071039

LCO:	104919600 104926153(map3k5)

NCC:

104941909

CGOB:

115003836(map3k5) 115021489

ELY:	117266425(si:ch211-1i11.3) 117270726(map3k5)

PLEP:

121945592(si:ch211-1i11.3) 121956006(map3k5)

SLUC:

116043308(si:ch211-1i11.3) 116066332(map3k5)

ECRA:

117946066(si:ch211-1i11.3) 117961775(map3k5)

PFLV:

114557214 114572961(map3k5)

GAT:	120807850(map3k5) 120810951(si:ch211-1i11.3)

PPUG:

119194695(map3k5) 119198012(si:ch211-1i11.3)

MSAM:

119897276(si:ch211-1i11.3) 119909551(map3k5)

CUD:	121513660(si:ch211-1i11.3) 121521244(map3k5)

MZE:	101473117(map3k5) 101482122

ONL:	100703888(map3k5) 100704269

OAU:	116311419(map3k5) 116320920(si:ch211-1i11.3)

OLA:	101167985 101175702(map3k5)

OML:	112143789(si:ch211-1i11.3) 112157978(map3k5)

XMA:	102232260 102232771(map3k5)

XCO:	114140993 114158595(map3k5)

XHE:	116717242 116734003(map3k5)

PRET:

103457283(map3k5) 103477798

PFOR:

103141536 103154474(map3k5)

PLAI:

106953170(map3k5) 106954894

PMEI:

106923310 106926889(map3k5)

GAF:	122825130(map3k5) 122831685(si:ch211-1i11.3)

CVG:	107082864(map3k5) 107084615

CTUL:

119778360(map3k5) 119793951(si:ch211-1i11.3)

GMU:	124862290(si:ch211-1i11.3) 124882075(map3k5)

NFU:	107377786(map3k5) 107379353

KMR:	108233483(map3k5) 108240373(si:ch211-1i11.3)

ALIM:

106524693 106528005(map3k5)

NWH:	119409920(si:ch211-1i11.3) 119418611(map3k5)

AOCE:

111572346 111589020(map3k5)

CSEM:

103381109(map3k5) 103388011

POV:	109633076 109635968(map3k5)

SSEN:

122775214(si:ch211-1i11.3) 122783889(map3k5)

HHIP:

117758302(map3k5) 117777402(si:ch211-1i11.3)

LCF:	108888903(map3k5) 108899499

SDU:	111235736 111237351(map3k5)

SLAL:

111661471(map3k5) 111661628

XGL:	120784389(si:ch211-1i11.3) 120789011(map3k5)

HCQ:	109523559 109528311(map3k5)

BPEC:

110172206(map3k5) 110174291

MALB:

109954686 109962300(map3k5)

SASA:

106571336 106583027 106605130 106607751(map3k5)

OTW:	112217549 112223073 112246634 112250094

OMY:	110489000 110517301(si:ch211-1i11.3) 110522164(map3k5) 110529540

OGO:	123990694 123995028 124005628 124017316

ONE:	115105478 115107688 115139480 115141219

SALP:

111954312 111958856 111973164 112070550

SNH:	120019685 120024017 120031096 120048328

ELS:	105017906(map3k5) 105019305

SFM:	108919179 108929292(map3k5)

PKI:	111843026(map3k5) 111848885

AANG:

118222942(si:ch211-1i11.3) 118230513(map3k5)

LOC:	102692342(map3k6) 102695902(map3k5)

PSPA:

121308330 121316398 121316932(map3k5)

ARUT:

117402892 117410928 117413367 117414092

LCM:	102352283(MAP3K6)

CMK:	103178324(map3k5) 103187330

SPU:

592507

DME:	Dmel_CG4720(Ask1)

DER:

6553939

DSE:

6619027

DSI:	Dsimw501_GD19320(Dsim_GD19320)

DYA:	Dyak_GE25632

DAN:

6500408

DSR:

110188207

DPO:	Dpse_GA18383(Dpse_Pk92B)

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI22433

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

MDE:

SCAC:

LCQ:

AGA:	AgaP_AGAP000747

ACOZ:

120958527

AARA:

120906704

AAG:	110681039 5570419

AALB:

115269543

CQU:	CpipJ_CPIJ008487

CPII:

CNS:

AME:

ACER:

ALAB:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BPYO:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

NVI:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

TCA:

SOY:

CSET:

AGB:

LDC:

APLN:

PPYR:

OTU:

MSEX:

BANY:

PPOT:

PXU:

PRAP:

ZCE:

OFU:

API:

DNX:

AGS:

RMD:

DCI:

HHAL:

NLU:

PHU:	Phum_PHUM596320

FOC:

ZNE:

CSEC:

DMK:

PVM:

PJA:

HAME:

PCLA:

PTRU:

HAZT:

EAF:	111695875 111718211

ISC:	IscW_ISCW002207

DSV:

RSAN:

RMP:

VDE:

VJA:

DFR:

SDM:

CEL:	CELE_F59A6.1(nsy-1)

CBR:	CBG_02299(Cbr-nsy-1)

BMY:	BM_BM12235(Bma-nsy-1)

LOA:	LOAG_18820

BGT:

GAE:

HRF:

HRJ:

PMAX:

MMER:

OSN:

SMM:	Smp_162800.1

HMG:

100206765

TAD:	TRIADDRAFT_10277

AQU:

100631731

MBR:	MONBRDRAFT_25232

» show all

Reference

PMID:12215209

Authors

Matsuzawa A, Nishitoh H, Tobiume K, Takeda K, Ichijo H

Title

Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.

Journal

Antioxid Redox Signal 4:415-25 (2002)
DOI:10.1089/15230860260196218

Reference

PMID:8940179

Authors

Wang XS, Diener K, Jannuzzi D, Trollinger D, Tan TH, Lichenstein H, Zukowski M, Yao Z

Title

Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase.

Journal

J Biol Chem 271:31607-11 (1996)
DOI:10.1074/jbc.271.49.31607

Sequence

[hsa:4217]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (44)   
   KEGG PATHWAY (44)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2180)   
   KEGG GENES (466)   
   KEGG MGENES (297)   
   RefGene (1407)   
   OC (10)   
Literature (2)   
   PubMed (2)   
All databases (2232)   

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