KEGG ORTHOLOGY: K04426

ORTHOLOGY: K04426

Entry

K04426                      KO

Symbol

MAP3K5, ASK1

Name

mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]

Pathway

map01524

Platinum drug resistance

map04010

MAPK signaling pathway

map04013

MAPK signaling pathway - fly

map04071

Sphingolipid signaling pathway

map04141

Protein processing in endoplasmic reticulum

map04210

Apoptosis

map04214

Apoptosis - fly

map04530

Tight junction

map04668

TNF signaling pathway

map04714

Thermogenesis

map04722

Neurotrophin signaling pathway

map04932

Non-alcoholic fatty liver disease

map04936

Alcoholic liver disease

map05010

Alzheimer disease

map05012

Parkinson disease

map05014

Amyotrophic lateral sclerosis

map05016

Huntington disease

map05017

Spinocerebellar ataxia

map05022

Pathways of neurodegeneration - multiple diseases

map05208

Chemical carcinogenesis - reactive oxygen species

map05417

Lipid and atherosclerosis

map05418

Fluid shear stress and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   04013 MAPK signaling pathway - fly
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   04668 TNF signaling pathway
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   04071 Sphingolipid signaling pathway
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   04214 Apoptosis - fly
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  09159 Environmental adaptation
   04714 Thermogenesis
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   05012 Parkinson disease
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   05014 Amyotrophic lateral sclerosis
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   05016 Huntington disease
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   05017 Spinocerebellar ataxia
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   05022 Pathways of neurodegeneration - multiple diseases
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   05418 Fluid shear stress and atherosclerosis
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   04932 Non-alcoholic fatty liver disease
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
Protein kinases [BR:ko01001]
Serine/threonine kinases: STE group
  STE11 family
   K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5

Other DBs

GO:

0004709

Genes

HSA:	4217(MAP3K5)

PTR:	463023(MAP3K5)

PPS:	100991014(MAP3K5)

GGO:	101147354(MAP3K5)

PON:	100458776(MAP3K5)

PPYG:

129038517(MAP3K5)

NLE:	100587332(MAP3K5)

HMH:	116472781(MAP3K5)

SSYN:

129473996(MAP3K5)

MCC:	711382(MAP3K5)

MCF:	101925657(MAP3K5)

MTHB:

126952847

MNI:	105465677(MAP3K5)

CSAB:

103240310(MAP3K5)

CATY:

105600400(MAP3K5)

PANU:

101002917(MAP3K5)

TGE:	112623422(MAP3K5)

MLEU:

105538551(MAP3K5)

RRO:	104675014(MAP3K5)

RBB:	108522968(MAP3K5)

TFN:	117097478(MAP3K5)

PTEH:

111525521(MAP3K5)

CANG:

105526172(MAP3K5)

CJC:	100406322(MAP3K5)

SBQ:	101034123(MAP3K5)

CIMI:

108305646(MAP3K5)

ANAN:

105732372(MAP3K5)

CSYR:

103256327(MAP3K5)

MMUR:

105857227(MAP3K5)

LCAT:

123633303(MAP3K5)

PCOQ:

105827162(MAP3K5)

OGA:	100943232(MAP3K5)

MMU:	26408(Map3k5)

MCAL:

110303338(Map3k5)

MPAH:

110337870(Map3k5)

RNO:	365057(Map3k5)

MCOC:

116097922(Map3k5)

ANU:	117701010(Map3k5)

ASYL:

127674176(Map3k5)

MUN:	110554628(Map3k5)

CGE:	100752376(Map3k5)

MAUA:

101833650(Map3k5)

PROB:

127215051(Map3k5)

MORG:

121449186(Map3k5)

MFOT:

126511959

AAMP:

119820587(Map3k5)

NGI:	103724902(Map3k5)

HGL:	101712051(Map3k5)

CPOC:

100722979(Map3k5)

CCAN:

109697041(Map3k5)

DORD:

105993516(Map3k5)

DSP:	122126135(Map3k5)

DMER:

138819251(Map3k5)

PLOP:

125357320(Map3k5)

NCAR:

124988565

MMMA:

107155636(Map3k5)

ITI:	101976557(Map3k5)

OCU:

100340498

OPI:	101530376(MAP3K5)

TUP:	102495244(MAP3K5)

GVR:	103591967(MAP3K5)

CFA:	476215(MAP3K5)

CLUD:

112644173(MAP3K5)

VVP:	112919386(MAP3K5)

VLG:	121481859(MAP3K5)

NPO:	129509222(MAP3K5)

AML:	100475304(MAP3K5)

UMR:	103663496(MAP3K5)

UAH:	113259481(MAP3K5)

UAR:	123803353(MAP3K5)

ELK:

111147502

LLV:

125103005

MPUF:

101686402(MAP3K5)

MNP:	132018185(MAP3K5)

MLK:	131833762(MAP3K5)

NVS:	122906270(MAP3K5)

ORO:	101374728(MAP3K5)

EJU:	114222735(MAP3K5)

ZCA:	113927218(MAP3K5)

MLX:	118000829(MAP3K5)

NSU:	110583064(MAP3K5)

LWW:	102738241(MAP3K5)

FCA:	101082912(MAP3K5)

PYU:	121013412(MAP3K5)

PCOO:

112862885(MAP3K5)

PBG:	122490389(MAP3K5)

PVIV:

125165204(MAP3K5)

LRUF:

124528854

LGF:	123609057(MAP3K5)

AJU:

106983673

PTG:	102960317(MAP3K5)

PPAD:

109249879(MAP3K5)

PUC:

125938936

PLEZ:

122220413(MAP3K5)

HHV:	120222015 120239371

BTA:	537380(MAP3K5)

BOM:	102276849(MAP3K5)

BIU:	109563980(MAP3K5)

BBUB:

102408502(MAP3K5)

BBIS:

104991715(MAP3K5)

CHX:	102172156(MAP3K5)

OAS:	101121018(MAP3K5)

BTAX:

128053214(MAP3K5)

CSUM:

138089668(MAP3K5)

ODA:	120863070(MAP3K5)

CCAD:

122433913(MAP3K5)

MREE:

136165208(MAP3K5)

OVR:	110140316(MAP3K5)

MBEZ:

129560696(MAP3K5)

SSC:	100622769(MAP3K5)

CFR:	102522243(MAP3K5)

CBAI:

105077264(MAP3K5)

CDK:	105092037(MAP3K5)

VPC:	102544996(MAP3K5)

BACU:

102999328(MAP3K5)

BMUS:

118905124(MAP3K5)

OOR:	101277232(MAP3K5)

LALB:

132530573(MAP3K5)

GMF:	115851408(MAP3K5)

DLE:	111166150(MAP3K5)

PCAD:

102976909(MAP3K5)

PSIU:

116763459(MAP3K5)

PPHC:

136132246(MAP3K5)

NASI:

112409119(MAP3K5)

ECB:	100073186(MAP3K5)

EPZ:	103556363(MAP3K5)

EAI:	106837192(MAP3K5)

MYB:	102256847(MAP3K5)

MYD:	102771311(MAP3K5)

MMYO:

118659758(MAP3K5)

MLF:	102439932(MAP3K5)

MDT:	132236918(MAP3K5)

MYUM:

139012195(MAP3K5)

PKL:	118705482(MAP3K5)

EFUS:

103305290(MAP3K5)

MNA:	107530984(MAP3K5)

DRO:	112297079(MAP3K5)

SHON:

118986673(MAP3K5)

AJM:	119052787(MAP3K5)

PDIC:

114494013(MAP3K5)

PHAS:

123821582(MAP3K5)

MMF:	118620900(MAP3K5)

PPAM:

129067800(MAP3K5)

HAI:	109385622(MAP3K5)

RFQ:	117020789(MAP3K5)

PALE:

102888994(MAP3K5)

PGIG:

120615779(MAP3K5)

PVP:	105289473(MAP3K5)

RAY:	107521291(MAP3K5)

MJV:	108401094(MAP3K5)

TOD:	119252904(MAP3K5)

SARA:

101547499(MAP3K5)

SFUM:

130034511(MAP3K5)

SETR:

126029694(MAP3K5)

LAV:	100658813(MAP3K5)

TMU:

101346612

ETF:	101645193(MAP3K5)

DNM:	101411083(MAP3K5)

MDO:	100031527(MAP3K5)

GAS:	123247967(MAP3K5)

SHR:	100917439(MAP3K5)

AFZ:

127562250

PCW:	110208922(MAP3K5)

TVP:	118857010(MAP3K5)

PBRV:

138153106(MAP3K5)

MLAO:

141488006(MAP3K5)

OAA:	100081079(MAP3K5)

TACU:

119945193(MAP3K5)

GGA:	421688(MAP3K5)

PCOC:

116240569(MAP3K5)

CJO:	107311662(MAP3K5)

TPAI:

128076633(MAP3K5)

LMUT:

125690192(MAP3K5)

NMEL:

110395802(MAP3K5)

APLA:

101799109(MAP3K5)

ACYG:

106032515(MAP3K5)

CATA:

118243870(MAP3K5)

AFUL:

116487197(MAP3K5)

TGU:	100224192(MAP3K5)

LSR:	110483316(MAP3K5)

SCAN:

103818465(MAP3K5)

PMOA:

120501237(MAP3K5)

OTC:	121346192(MAP3K5)

PRUF:

121354869(MAP3K5)

ATRC:

139593067(MAP3K5)

GFR:	102034507(MAP3K5)

FAB:	101813811(MAP3K5)

OMA:	130251886(MAP3K5)

PHI:	102104081(MAP3K5)

PMAJ:

107201551(MAP3K5)

CCAE:

111926799(MAP3K5)

CCW:	104689448(MAP3K5)

CBRC:

103617648(MAP3K5)

ACOE:

138108187(MAP3K5)

ETL:	114059498(MAP3K5)

ZAB:	102060991(MAP3K5)

ZLE:	135445611(MAP3K5)

ACHL:

103801419(MAP3K5)

SVG:	106854874(MAP3K5)

MMEA:

130581270(MAP3K5)

HRT:	120750435(MAP3K5)

SATI:

136359196(MAP3K5)

CCIC:

134042558(MAP3K5)

FPG:	101911552(MAP3K5)

FCH:	102057038(MAP3K5)

NNT:	104410334(MAP3K5)

SHAB:

115609559(MAP3K5)

ACUN:

113478110(MAP3K5)

TALA:

104366747(MAP3K5)

ACHC:

115344983(MAP3K5)

HLE:	104836212(MAP3K5)

AGEN:

126038293

HHAR:

128140531(MAP3K5)

GCL:

127014170

CSTI:

104560384(MAP3K5)

LDI:	104344415(MAP3K5)

MNB:	103777114(MAP3K5)

DPUB:

104310010(MAP3K5)

PPUS:

135189108(MAP3K5)

AVIT:

104270448(MAP3K5)

EGZ:	104131143(MAP3K5)

NNI:	104008816(MAP3K5)

PCRI:

104037846

PCAO:

104047047(MAP3K5)

PADL:

103912745(MAP3K5)

AFOR:

103900805(MAP3K5)

FGA:	104076852(MAP3K5)

GSTE:

104254793(MAP3K5)

CBOY:

140649156(MAP3K5)

CLV:	102085051(MAP3K5)

CNIC:

135986808(MAP3K5)

MUI:	104540113(MAP3K5)

CMAC:

104484632

CUCA:

104056238(MAP3K5)

BREG:

104641756(MAP3K5)

OHA:	104327076(MAP3K5)

CPEA:

104395821(MAP3K5)

CVF:	104284018(MAP3K5)

RTD:	128906912(MAP3K5)

CRID:

134513204(MAP3K5)

AAM:	106497979(MAP3K5)

AROW:

112977195(MAP3K5)

NPD:	112954904(MAP3K5)

TGT:	104570863(MAP3K5)

DNE:	112996005(MAP3K5)

SCAM:

104153171(MAP3K5)

ASN:	102375722(MAP3K5)

AMJ:	102573024(MAP3K5)

CPOO:

109320192(MAP3K5)

GGN:	109304590(MAP3K5)

PSS:	102451227(MAP3K5)

CMY:	102936034(MAP3K5)

CCAY:

125634135(MAP3K5)

DCC:	119853200(MAP3K5)

CPIC:

101943963(MAP3K5)

TST:	117874903(MAP3K5)

CABI:

116818836(MAP3K5)

MRV:	120402164(MAP3K5)

ACS:	100551616(map3k5)

ASAO:

132760994(MAP3K5)

PVT:	110071741(MAP3K5)

SUND:

121932476(MAP3K5)

PBI:	103052010(MAP3K5)

PMUR:

107282238(MAP3K5)

CTIG:

120298923(MAP3K5)

TSR:	106554087(MAP3K5)

PGUT:

117666295(MAP3K5)

PCAE:

139308821(MAP3K5)

APRI:

131192139(MAP3K5)

PTEX:

113439618(MAP3K5)

NSS:	113411203(MAP3K5) 113417608

VKO:	123020316(MAP3K5) 123026039(MAP3K6)

PMUA:

114594175(MAP3K5)

PRAF:

128410572(MAP3K5)

ZVI:	118082069(MAP3K5)

HCG:	128341991(MAP3K5)

GJA:

107117647

STOW:

125429099(MAP3K5)

EMC:	129327359(MAP3K5)

XLA:

108717885

XTR:	100497692(map3k5)

NPR:	108787404(MAP3K5)

RTEM:

120937349(MAP3K5)

ACAT:

141140309(MAP3K5)

BBUF:

120998524(MAP3K5)

BGAR:

122934291(MAP3K5)

DTC:	141089458(MAP3K5)

PWL:	138285381 138295973(MAP3K5)

MUO:	115466925(MAP3K5) 115479652(MAP3K6)

GSH:	117357150(MAP3K5) 117366150(MAP3K6)

DRE:	100005496(si:ch211-1i11.3) 555703(map3k5)

SRX:	107705646 107740525(map3k5) 107755537

SANH:

107653159 107660504 107700717 107704978

SGH:	107554152 107556089 107570516 107588497

CCAR:

109048836 109051603(map3k5) 109092120 109105413

CAUA:

113037674 113063497 113115999

CGIB:

127938309 127974831(si:ch211-1i11.3) 127984350 128030501

PTET:

122334658(map3k5) 122360136(si:ch211-1i11.3)

LROH:

127178933(si:ch211-1i11.3) 127182713(map3k5)

GRF:	141283778(map3k5) 141342248 141343161

OMC:	131521476(si:ch211-1i11.3) 131527039(map3k5)

PPRM:

120475531 120475545 120484263(si:ch211-1i11.3)

RKG:	130090011(map3k5) 130104362(si:ch211-1i11.3)

MAMB:

125242985(si:ch211-1i11.3) 125278830(map3k5)

CIDE:

127497386(si:ch211-1i11.3) 127502840

CERY:

137015706 137016154 137033290(si:ch211-1i11.3)

MASI:

127409880 127416152 127453288 127453980

TROS:

130557759(si:ch211-1i11.3) 130565621(map3k5)

TDW:	130433109(si:ch211-1i11.3) 130434052(map3k5)

MANU:

129448419 141350520(map3k5)

PDAB:

135750169(map3k5) 135788946

IPU:	108257027 108268173(si:ch211-1i11.3)

IFU:	128612271(si:ch211-1i11.3) 128619806(map3k5)

PHYP:

113526624 113528943(map3k5)

SMEO:

124384976(si:ch211-1i11.3) 124401148(map3k5)

TFD:	113644595(si:ch211-1i11.3) 113646298(map3k5)

TVC:	132845743(si:ch211-1i11.3) 132854438(map3k5)

CGAR:

128507175(map3k5) 128520140(si:ch211-1i11.3)

NGRA:

132881476(map3k5) 132886953(si:ch211-1i11.3)

TRN:	134309923(si:ch211-1i11.3) 134320459(map3k5)

AMEX:

103033000(map3k5) 103038360(si:ch211-1i11.3)

CMAO:

118800999 118819190(si:ch211-1i11.3)

EEE:	113572229 113589755(map3k5)

CHAR:

105897682(si:ch211-1i11.3) 105899459(map3k5)

SPIL:

134083150(si:ch211-1i11.3) 134098564(map3k5)

TRU:	101061432(map3k5) 101071039

TFS:	130516277(map3k5) 130532364(si:ch211-1i11.3)

LCO:	104919600 104926153(map3k5)

NCC:

104941909

TBEN:

117468561(si:ch211-1i11.3) 117486921(map3k5)

CGOB:

115003836(map3k5) 115021489

PGEO:

117439553(map3k5) 117461107

GACU:

117534861(map3k5) 117557197(si:ch211-1i11.3)

EMAC:

134862207(si:ch211-1i11.3) 134877344(map3k5)

ELY:	117266425(si:ch211-1i11.3) 117270726(map3k5)

EFO:	125892777(si:ch211-1i11.3) 125896958(map3k5)

PLEP:

121945592(si:ch211-1i11.3) 121956006(map3k5)

SLUC:

116043308(si:ch211-1i11.3) 116066332(map3k5)

ECRA:

117946066(si:ch211-1i11.3) 117961775(map3k5)

ESP:	116690444 116706745(map3k5)

PFLV:

114557214 114572961(map3k5)

GAT:	120807850(map3k5) 120810951(si:ch211-1i11.3)

PPUG:

119194695(map3k5) 119198012(si:ch211-1i11.3)

AFB:	129107095(map3k5) 129109066(si:ch211-1i11.3)

CLUM:

117727038(map3k5) 117745695(si:ch211-1i11.3)

PSWI:

130203090(map3k5) 130212975(si:ch211-1i11.3)

CANA:

137781043(si:ch211-1i11.3) 137785625(map3k5)

CVE:	137870944(map3k5) 137891321(si:ch211-1i11.3)

MSAM:

119897276(si:ch211-1i11.3) 119909551(map3k5)

SCHU:

122862735(map3k5) 122881813(si:ch211-1i11.3)

CUD:	121513660(si:ch211-1i11.3) 121521244(map3k5)

SPUL:

138583520(map3k5) 138583806

LMIX:

132983712(si:ch211-1i11.3) 132984743(map3k5)

ALAT:

119006443(si:ch211-1i11.3) 119012440(map3k5)

ASTR:

137601591(si:ch211-1i11.3) 137613020(map3k5)

MZE:	101473117(map3k5) 101482122

ONL:	100703888(map3k5) 100704269

OAU:	116311419(map3k5) 116320920(si:ch211-1i11.3)

OLA:	101167985 101175702(map3k5)

OML:	112143789(si:ch211-1i11.3) 112157978(map3k5)

CSAI:

133418627(map3k5) 133437111(si:ch211-1i11.3)

XMA:	102232260 102232771(map3k5)

XCO:	114140993 114158595(map3k5)

XHE:	116717242 116734003(map3k5)

PRET:

103457283(map3k5) 103477798

PFOR:

103141536 103154474(map3k5)

PLAI:

106953170(map3k5) 106954894

PMEI:

106923310 106926889(map3k5)

GAF:	122825130(map3k5) 122831685(si:ch211-1i11.3)

PPRL:

129370974(si:ch211-1i11.3) 129375300(map3k5)

CVG:	107082864(map3k5) 107084615

CTUL:

119778360(map3k5) 119793951(si:ch211-1i11.3)

GMU:	124862290(si:ch211-1i11.3) 124882075(map3k5)

NFU:	107377786(map3k5) 107379353

KMR:	108233483(map3k5) 108240373(si:ch211-1i11.3)

ALIM:

106524693 106528005(map3k5)

NWH:	119409920(si:ch211-1i11.3) 119418611(map3k5)

AOCE:

111572346(si:ch211-1i11.3) 111589020(map3k5)

EJA:	138193742 138205699(map3k5)

BFRE:

138623987 138630852(map3k5)

MCEP:

125016978(si:ch211-1i11.3)

CSEM:

103381109(map3k5) 103388011

POV:	109633076 109635968(map3k5)

SSEN:

122775214(si:ch211-1i11.3) 122783889(map3k5)

SSOE:

131443365(map3k5) 131471708(si:ch211-1i11.3)

HHIP:

117758302(map3k5) 117777402(si:ch211-1i11.3)

HSP:	118099367(map3k5) 118113345(si:ch211-1i11.3)

PPLT:

128449805(si:ch211-1i11.3) 128459938(map3k5)

SMAU:

118287465(si:ch211-1i11.3) 118289841(map3k5)

LCF:	108888903 108899499(si:ch211-1i11.3)

SDU:	111235736 111237351(map3k5)

SLAL:

111661471(map3k5) 111661628

XGL:	120784389(si:ch211-1i11.3) 120789011(map3k5)

HCQ:	109523559 109528311(map3k5)

SSCV:

125974977(si:ch211-1i11.3) 125990121(map3k5)

SBIA:

133496250(map3k5) 133500350(si:ch211-1i11.3)

PEE:	133401281(si:ch211-1i11.3) 133416918(map3k5)

PTAO:

133467900(map3k5) 133479543(si:ch211-1i11.3)

BPEC:

110172206(map3k5) 110174291

ENY:	140359889(map3k5) 140374133

MALB:

109954686 109962300(map3k5)

BSPL:

114843264(si:ch211-1i11.3) 114850059(map3k5)

SJO:	128365967(si:ch211-1i11.3) 128376936(map3k5)

SSCO:

133983161(si:ch211-1i11.3) 133997576(map3k5)

GMH:	115534175(map3k5) 115545148

SASA:

106571336 106583027 106605130 106607751(map3k5)

STRU:

115174881 115176896 115177194 115193987

OTW:	112217549 112223073 112246634 112250094

OMY:	110489000 110517301(si:ch211-1i11.3) 110522164(map3k5) 110529540

OGO:	123990694 123995028 124005628 124017316

ONE:	115105478 115107688 115139480 115141219

OKI:	109866710 109900687 109902148 109909944

OKE:	118364282 118367356 118386825 118398724

OMM:	135506032 135520098 135522394 135557527(map3k5)

OCLA:

139366442 139393641 139407072 139415082

SALP:

111954312 111958856 111973164 112070550

SNH:	120019685 120024017 120031096 120048328

CCLU:

121542150 121548986 121552096 121586874

ELS:	105017906(map3k5) 105019305

OEP:	134024064(si:ch211-1i11.3) 134025063(map3k5)

SFM:	108919179 108929292(map3k5)

PKI:	111843026(map3k5) 111848885

AANG:

118222942(si:ch211-1i11.3) 118230513(map3k5)

AROT:

135239297(si:ch211-1i11.3) 135257380(map3k5)

CCOG:

133128454(map3k5) 133132293(si:ch211-1i11.3)

LOC:	102692342(map3k6) 102695902(map3k5)

PSPA:

121308330 121316398 121316932(map3k5)

ARUT:

117402892 117410928 117413367 117414092

PSEX:

120517520(si:ch211-1i11.3) 120525315(map3k5)

LCM:	102352283(MAP3K6)

CMK:	103178324(map3k5) 103187330

RTP:	109919598(map3k5)

CPLA:

122547340(map3k5) 122563748

HOC:	132830155 132832175(map3k5)

LERI:

129697414 129709625(si:ch211-1i11.3)

HAKA:

SPU:

AJJ:

ARUN:

AAMU:

AFIL:

PFLL:

DME:	Dmel_CG4720(Ask1)

DER:

6553939

DSE:

6619027

DSI:	Dsimw501_GD19320(Dsim_GD19320)

DYA:	Dyak_GE25632

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI22433

DAZ:

108614318

DNV:

108657357

DHE:

111596705

DVI:	6632503(Ask1)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:	119675518 119681815

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135949464(Ask1)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:	110681039 5570419

AALB:

115269543

ASUA:

134205760

CQU:	CpipJ_CPIJ008487

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:	108725561(Ask1)

PBAR:

105427967

VEM:

105561019

COBS:

139109127(Ask1)

TLN:	139812690(Ask1)

HST:

DQU:

CFO:

FEX:

PMEC:

138940387(Ask1)

LHU:	105675456(Ask1)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

TPRE:

LHT:

LBD:

MDL:

CGLO:

CTYP:

141524546(Ask1)

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124216373(Ask1)

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138134327(Ask1)

DPA:

109534091

ESIM:

136410621(Ask1)

EFOR:

136345792(Ask1)

SOY:

AGRG:

CSET:

HAXR:

AGB:

LDC:

DVV:

APLN:

PPYR:

BMOR:

100529210(ask1)

BMAN:

114248799

MSEX:

115443887

DPL:	KGM_201965

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137932646(Ask1)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

141432142(Ask1)

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

DCI:

HHAL:

106686083(Ask1)

NLU:

111046568

HVI:

124358920

MQU:

128989923

PHU:	Phum_PHUM596320

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138710936(Ask1)

SGRE:

126278688

BROR:

134533236

IEL:

124161210

HAMR:

139694661(Ask1)

DMK:

116922300

DPZ:

124340078

AFRA:

136036336 136036346

PVM:	113816913(Ask1)

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:	128701655(Ask1)

PTRU:

123502841

ESN:

127005505

MNZ:

135197474

MRJ:	136838653(Ask1)

PORN:

139765950(Ask1)

HAZT:

108669933 108675863

EAF:	111695875 111718211

LSM:	121125413(Ask1)

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

GOE:

DPTE:

DFR:

CSCU:

CVS:	136974114(Ask1)

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_F59A6.1(nsy-1)

CBR:	CBG_02299(Cbr-nsy-1)

BMY:	BM_BM12235(Bma-nsy-1)

LOA:	LOAG_18820

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

OED:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OSN:

LJP:

SMM:	Smp_162800.1

SHX:	MS3_00010479(MAP3K5)

LLON:

135488755

HMG:

100206765

RES:

135685680

TAD:	TRIADDRAFT_10277

AQU:

100631731

MBR:	MONBRDRAFT_25232

» show all

Reference

PMID:12215209

Authors

Matsuzawa A, Nishitoh H, Tobiume K, Takeda K, Ichijo H

Title

Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.

Journal

Antioxid Redox Signal 4:415-25 (2002)
DOI:10.1089/15230860260196218

Reference

PMID:8940179

Authors

Wang XS, Diener K, Jannuzzi D, Trollinger D, Tan TH, Lichenstein H, Zukowski M, Yao Z

Title

Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase.

Journal

J Biol Chem 271:31607-11 (1996)
DOI:10.1074/jbc.271.49.31607

Sequence

[hsa:4217]

All links

Ontology (1)   
   GO (1)   
Gene (1927)   
   MGENES (510)   
   RefGene (1407)   
   OC (10)   
All databases (1928)   

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