KEGG   ORTHOLOGY: K04427
Entry
K04427                      KO                                     

Name
MAP3K7, TAK1
Definition
mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
Pathway
ko04010  MAPK signaling pathway
ko04013  MAPK signaling pathway - fly
ko04064  NF-kappa B signaling pathway
ko04140  Autophagy - animal
ko04152  AMPK signaling pathway
ko04214  Apoptosis - fly
ko04310  Wnt signaling pathway
ko04380  Osteoclast differentiation
ko04520  Adherens junction
ko04613  Neutrophil extracellular trap formation
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04624  Toll and Imd signaling pathway
ko04657  IL-17 signaling pathway
ko04660  T cell receptor signaling pathway
ko04668  TNF signaling pathway
ko05130  Pathogenic Escherichia coli infection
ko05131  Shigellosis
ko05132  Salmonella infection
ko05135  Yersinia infection
ko05140  Leishmaniasis
ko05145  Toxoplasmosis
ko05161  Hepatitis B
ko05162  Measles
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05171  Coronavirus disease - COVID-19
ko05417  Lipid and atherosclerosis
ko05418  Fluid shear stress and atherosclerosis
Disease
H02226  Cardiospondylocarpofacial syndrome
H02227  Frontometaphyseal dysplasia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04013 MAPK signaling pathway - fly
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04310 Wnt signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04064 NF-kappa B signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04668 TNF signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04152 AMPK signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
  09143 Cell growth and death
   04214 Apoptosis - fly
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04620 Toll-like receptor signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04624 Toll and Imd signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04621 NOD-like receptor signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04622 RIG-I-like receptor signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04660 T cell receptor signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04657 IL-17 signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05161 Hepatitis B
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05171 Coronavirus disease - COVID-19
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05162 Measles
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05168 Herpes simplex virus 1 infection
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05169 Epstein-Barr virus infection
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05132 Salmonella infection
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05131 Shigellosis
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05135 Yersinia infection
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05140 Leishmaniasis
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05418 Fluid shear stress and atherosclerosis
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  MLK family
   K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
Other DBs
GO: 0004709
Genes
HSA: 6885(MAP3K7)
PTR: 462888(MAP3K7)
PPS: 100974026(MAP3K7)
GGO: 101144707(MAP3K7)
PON: 100171454(MAP3K7)
NLE: 100596471(MAP3K7)
MCC: 703101(MAP3K7)
MCF: 102140498(MAP3K7)
CSAB: 103240115(MAP3K7)
CATY: 105589048(MAP3K7)
PANU: 101013055(MAP3K7)
RRO: 104657888(MAP3K7)
RBB: 108539499(MAP3K7)
TFN: 117097099(MAP3K7)
CJC: 100403175(MAP3K7)
SBQ: 101045636(MAP3K7)
MMUR: 105863624(MAP3K7)
MMU: 26409(Map3k7)
MCAL: 110292293(Map3k7)
MPAH: 110338656(Map3k7)
RNO: 313121(Map3k7)
MCOC: 116088003(Map3k7)
CGE: 100774341(Map3k7)
PLEU: 114695419(Map3k7)
NGI: 103739547(Map3k7)
HGL: 101718269(Map3k7)
CCAN: 109698497(Map3k7)
OCU: 100343571(MAP3K7)
TUP: 102477331(MAP3K7)
CFA: 102156745(MAP3K7)
VVP: 112923157(MAP3K7)
VLG: 121496257(MAP3K7)
AML: 100466506(MAP3K7)
UMR: 103660092(MAP3K7)
UAH: 113264818(MAP3K7)
ORO: 101376824(MAP3K7)
ELK: 111158801
MPUF: 101682439(MAP3K7)
EJU: 114213021(MAP3K7)
MLX: 118001330(MAP3K7)
FCA: 101095899(MAP3K7)
PTG: 102963341(MAP3K7)
PPAD: 109263420(MAP3K7)
AJU: 106983077(MAP3K7)
HHV: 120231881(MAP3K7)
BTA: 529146(MAP3K7)
BOM: 102264816(MAP3K7)
BIU: 109563902(MAP3K7)
BBUB: 102415113(MAP3K7)
CHX: 102172719(MAP3K7)
OAS: 101108056(MAP3K7)
ODA: 120862713(MAP3K7)
SSC: 100135663(MAP3K7)
CFR: 102519538(MAP3K7)
CDK: 105095522(MAP3K7)
BACU: 103019299(MAP3K7)
LVE: 103075340(MAP3K7)
OOR: 101283961(MAP3K7)
DLE: 111163761(MAP3K7)
PCAD: 102995727(MAP3K7)
ECB: 100065841(MAP3K7)
EPZ: 103548805(MAP3K7)
EAI: 106847421(MAP3K7)
MYB: 102254118(MAP3K7)
MYD: 102763957(MAP3K7)
MMYO: 118659996(MAP3K7)
MNA: 107533446(MAP3K7)
HAI: 109389465(MAP3K7)
DRO: 112296959(MAP3K7)
SHON: 118982270(MAP3K7)
AJM: 119041421
MMF: 118621083(MAP3K7)
PALE: 102882452(MAP3K7)
RAY: 107508648(MAP3K7)
MJV: 108399127(MAP3K7)
LAV: 100667170(MAP3K7)
TMU: 101346094
MDO: 100019975(MAP3K7)
SHR: 100920997(MAP3K7)
PCW: 110192034(MAP3K7)
OAA: 100076229(MAP3K7)
GGA: 421808(MAP3K7)
PCOC: 116240737(MAP3K7)
MGP: 100539749(MAP3K7)
CJO: 107311964(MAP3K7)
NMEL: 110395624(MAP3K7)
ACYG: 106035399(MAP3K7)
TGU: 100221443(MAP3K7)
LSR: 110478595(MAP3K7)
SCAN: 103819102(MAP3K7)
PMOA: 120512386(MAP3K7)
GFR: 102039929(MAP3K7)
FAB: 101814532(MAP3K7)
PHI: 102107403(MAP3K7)
PMAJ: 107201717(MAP3K7)
CCAE: 111925720(MAP3K7)
CCW: 104692210(MAP3K7)
ETL: 114057792(MAP3K7)
FPG: 101917746(MAP3K7)
FCH: 102058816(MAP3K7)
EGZ: 104135405(MAP3K7)
NNI: 104021941(MAP3K7)
ACUN: 113478050(MAP3K7)
PADL: 103913621(MAP3K7)
AAM: 106489690(MAP3K7)
ASN: 102386999(MAP3K7)
AMJ: 102569201(MAP3K7)
CPOO: 109311869(MAP3K7)
GGN: 109299677(MAP3K7)
CMY: 102936052(MAP3K7)
CPIC: 101931315(MAP3K7)
TST: 117875099(MAP3K7)
CABI: 116820302(MAP3K7)
ACS: 100554725(map3k7)
PVT: 110074609(MAP3K7)
PBI: 103067633(MAP3K7)
PMUR: 107301663 107302815(MAP3K7)
TSR: 106549515(MAP3K7)
PGUT: 117660774(MAP3K7)
PMUA: 114593961(MAP3K7)
ZVI: 118082247(MAP3K7)
GJA: 107114874(MAP3K7)
XLA: 379399(map3k7.S) 399459(map3k7.L)
XTR: 100101764(map3k7)
NPR: 108800110(MAP3K7)
DRE: 553788(map3k7)
CCAR: 109064262
IPU: 108256841(map3k7)
PHYP: 113529033(map3k7)
AMEX: 103039333(map3k7)
EEE: 113579878(map3k7)
TRU: 101063524(map3k7)
LCO: 104924081(map3k7) 104928162
ELY: 117267585 117270756(map3k7)
PLEP: 121953646 121955268(map3k7)
SLUC: 116040316(map3k7) 116065811
GAT: 120808062(map3k7) 120833079
MSAM: 119908660(map3k7) 119911008
CUD: 121520896(map3k7) 121526674
MZE: 101475992 101484924(map3k7)
ONL: 100689877(map3k7) 100699877
OAU: 116321722(map3k7) 116330303
OLA: 101164271(map3k7) 105356874
OML: 112154196 112158233(map3k7)
XMA: 102226534(map3k7) 102232287
XCO: 114133938 114158518(map3k7)
XHE: 116709106 116733629(map3k7)
PRET: 103457977(map3k7) 103458953
NFU: 107395980(map3k7)
KMR: 108245043 108251536(map3k7)
ALIM: 106519963 106535535(map3k7)
AOCE: 111566069(map3k7)
CSEM: 103380691(map3k7)
POV: 109628158 109632517(map3k7)
LCF: 108897885 108899288(map3k7)
SDU: 111226008 111238781(map3k7)
SLAL: 111645547 111661524(map3k7)
XGL: 120788739(map3k7) 120795051
HCQ: 109529256
BPEC: 110154967 110171242(map3k7)
MALB: 109959709 109967378(map3k7)
ELS: 105015746 105017873(map3k7)
SFM: 108929345(map3k7)
PKI: 111843005(map3k7)
LOC: 102693991(map3k7)
PSPA: 121315455 121317588(map3k7)
ARUT: 117402843 117411069(map3k7)
LCM: 102358159(MAP3K7)
CMK: 103178276(map3k7)
RTP: 109927672(map3k7)
BFO: 118423204
CIN: 778771(tak1/mapkkk7)
SPU: 590951
APLC: 110983312
SKO: 100313751
DME: Dmel_CG18492(Tak1) Dmel_CG31421(Takl1) Dmel_CG4803(Takl2)
DSI: Dsimw501_GD15532(Dsim_Tak1) Dsimw501_GD18431(Dsim_GD18431) Dsimw501_GD20035(Dsim_GD20035)
DYA: Dyak_GE15342(Dyak_Tak1)
DVI: 6632056
MDE: 101898114
LCQ: 111684006
ACOZ: 120951365
AARA: 120908898
AAG: 5568685
AME: 413809
ACER: 108001395
BIM: 100746656
BTER: 100631093
OBB: 114873005
MGEN: 117224228
NMEA: 116426528
SOC: 105207936
MPHA: 105838917
AEC: 105150983
ACEP: 105619960
PBAR: 105427629
VEM: 105570275
HST: 105187438
DQU: 106752216
CFO: 105256050
FEX: 115245292
LHU: 105676340
PGC: 109853437
OBO: 105284644
PCF: 106793886
NVI: 100120628
CSOL: 105366930
MDL: 103579917
TCA: 656961(Tak1)
DPA: 109538196
ATD: 109608402
AGB: 108903524
NVL: 108560912
APLN: 108742378
PPYR: 116161311
OTU: 111426480
BMOR: 101744000
BMAN: 114242540
MSEX: 115440218
BANY: 112045234
PMAC: 106721022
PPOT: 106110870
PXU: 106126784
PRAP: 110998182
ZCE: 119840187
HAW: 110382235
PXY: 105380044
API: 100159713
DNX: 107169096
AGS: 114123134
RMD: 113553054
DCI: 103517530
CLEC: 106666550
NLU: 111053447
ZNE: 110836178
CSEC: 111862208
FCD: 110853786
PVM: 113820640
HAME: 121879194
EAF: 111715843
DSV: 119461765
RSAN: 119395590
VDE: 111246648
VJA: 111265870
TUT: 107362121
DPTE: 113799863
CSCU: 111632919
PTEP: 107450902
SDM: 118197492
CEL: CELE_F52F12.3(mom-4) CELE_Y105C5A.24(Y105C5A.24)
CBR: CBG03852(Cbr-mom-4)
PCAN: 112566950
BGT: 106060407
GAE: 121370565
CRG: 105332318
MYI: 110455078
OBI: 106880926
LAK: 106163922
NVE: 5519317
EPA: 110249937
ATEN: 116302330
ADF: 107335569
AMIL: 114961241
DGT: 114526269
VAR: 108340739
VUN: 114175685
CAM: 101505952
LANG: 109331017
APRO: F751_0620
 » show all
Reference
PMID:9079627
  Authors
Shirakabe K, Yamaguchi K, Shibuya H, Irie K, Matsuda S, Moriguchi T, Gotoh Y, Matsumoto K, Nishida E
  Title
TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase.
  Journal
J Biol Chem 272:8141-4 (1997)
DOI:10.1074/jbc.272.13.8141
  Sequence
[hsa:6885]
Reference
PMID:9480845
  Authors
Sakurai H, Shigemori N, Hasegawa K, Sugita T
  Title
TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism.
  Journal
Biochem Biophys Res Commun 243:545-9 (1998)
DOI:10.1006/bbrc.1998.8124
  Sequence
[hsa:6885]

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