KEGG   ORTHOLOGY: K04447Help
Entry
K04447                      KO                                     

Name
JAK2
Definition
Janus kinase 2 [EC:2.7.10.2]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04062  Chemokine signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04217  Necroptosis
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04630  JAK-STAT signaling pathway
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04725  Cholinergic synapse
ko04917  Prolactin signaling pathway
ko04920  Adipocytokine signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05140  Leishmaniasis
ko05145  Toxoplasmosis
ko05152  Tuberculosis
ko05161  Hepatitis B
ko05162  Measles
ko05164  Influenza A
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex infection
ko05200  Pathways in cancer
Module
M00684  JAK-STAT signaling
Disease
H00012  Polycythemia vera
H01433  Budd-Chiari syndrome
H01481  Myelodysplastic syndrome
H01605  Myelofibrosis
H01612  Essential thrombocytosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 Jak-STAT signaling pathway
    K04447  JAK2; Janus kinase 2
   04151 PI3K-Akt signaling pathway
    K04447  JAK2; Janus kinase 2
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K04447  JAK2; Janus kinase 2
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K04447  JAK2; Janus kinase 2
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    K04447  JAK2; Janus kinase 2
   04659 Th17 cell differentiation
    K04447  JAK2; Janus kinase 2
   04062 Chemokine signaling pathway
    K04447  JAK2; Janus kinase 2
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K04447  JAK2; Janus kinase 2
   04917 Prolactin signaling pathway
    K04447  JAK2; Janus kinase 2
  09156 Nervous system
   04725 Cholinergic synapse
    K04447  JAK2; Janus kinase 2
 09160 Human Diseases
  09161 Cancers: Overview
   05200 Pathways in cancer
    K04447  JAK2; Janus kinase 2
  09167 Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04447  JAK2; Janus kinase 2
  09171 Infectious diseases: Bacterial
   05152 Tuberculosis
    K04447  JAK2; Janus kinase 2
  09172 Infectious diseases: Viral
   05162 Measles
    K04447  JAK2; Janus kinase 2
   05164 Influenza A
    K04447  JAK2; Janus kinase 2
   05161 Hepatitis B
    K04447  JAK2; Janus kinase 2
   05168 Herpes simplex infection
    K04447  JAK2; Janus kinase 2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04447  JAK2; Janus kinase 2
  09174 Infectious diseases: Parasitic
   05145 Toxoplasmosis
    K04447  JAK2; Janus kinase 2
   05140 Leishmaniasis
    K04447  JAK2; Janus kinase 2
  09176 Drug resistance: Antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04447  JAK2; Janus kinase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04447  JAK2; Janus kinase 2
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00684  JAK-STAT signaling
     K04447  JAK2; Janus kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K04447  JAK2; Janus kinase 2
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   K04447  JAK2; Janus kinase 2
BRITE hierarchy
Other DBs
GO: 0004715
Genes
HSA: 3717(JAK2)
PTR: 464979(JAK2)
PPS: 100979742(JAK2)
GGO: 101149427(JAK2)
PON: 100172517(JAK2)
NLE: 100588880(JAK2)
MCC: 694184(JAK2)
MCF: 102119008(JAK2)
CSAB: 103219496(JAK2)
RRO: 104665700(JAK2)
CJC: 100413251(JAK2)
SBQ: 101036986(JAK2)
MMU: 16452(Jak2)
RNO: 24514(Jak2)
CGE: 100769337(Jak2)
NGI: 103740979(Jak2)
HGL: 101717708(Jak2)
CCAN: 109692635(Jak2)
OCU: 100358134(JAK2)
TUP: 102502106(JAK2)
CFA: 484185(JAK2)
AML: 100481360(JAK2)
UMR: 103663212(JAK2)
ORO: 101375007(JAK2)
FCA: 101088959(JAK2)
PTG: 102950330(JAK2)
AJU: 106968145(JAK2)
BTA: 525246(JAK2)
BOM: 102278692(JAK2)
BIU: 109562906(JAK2)
PHD: 102339850(JAK2)
CHX: 102180670(JAK2)
OAS: 101113909(JAK2)
SSC: 397201(JAK2)
CFR: 102520220(JAK2)
CDK: 105101970(JAK2)
BACU: 103016904(JAK2)
LVE: 103076804(JAK2)
OOR: 101275108(JAK2)
ECB: 100051487(JAK2)
EPZ: 103554269(JAK2)
EAI: 106843620(JAK2)
MYB: 102253056(JAK2)
MYD: 102768196(JAK2)
HAI: 109384506(JAK2)
RSS: 109446401(JAK2)
PALE: 102882079(JAK2)
LAV: 100676652(JAK2)
TMU: 101354918
MDO: 100017930(JAK2)
SHR: 100927237(JAK2)
OAA: 100074305(JAK2)
GGA: 374199(JAK2)
MGP: 100548880(JAK2)
CJO: 107306093(JAK2) 107306121
APLA: 101799651(JAK2)
ACYG: 106046386(JAK2)
TGU: 100225452(JAK2)
SCAN: 103823830(JAK2)
GFR: 102037786(JAK2)
FAB: 101808382(JAK2)
PHI: 102110768(JAK2)
PMAJ: 107216082(JAK2)
CCAE: 111940605(JAK2)
CCW: 104685173(JAK2)
FPG: 101916887(JAK2)
FCH: 102051463(JAK2)
CLV: 102095126(JAK2)
EGZ: 104135381(JAK2)
NNI: 104021434(JAK2)
ACUN: 113490376(JAK2)
AAM: 106496764(JAK2)
ASN: 102370961(JAK2)
AMJ: 102569112(JAK2)
PSS: 102455115(JAK2)
CMY: 102932830(JAK2)
CPIC: 101952589(JAK2)
ACS: 100552375(jak2)
PVT: 110083245(JAK2)
PBI: 103049657(JAK2)
PMUR: 107291603(JAK2)
GJA: 107107201(JAK2)
XLA: 108705365(jak2.S) 443637(jak2.L)
XTR: 100036599(jak2)
NPR: 108798500(JAK2)
DRE: 30298(jak2b) 30307(jak2a)
IPU: 108255897 108265879(jak3) 108278781(jak2)
PRET: 103463505(jak3) 103469946 103473642(jak2)
CSEM: 103389123(jak2) 103395797(jak3) 103397589
SDU: 111218194(jak3) 111234160(jak2) 111236466
LCM: 102352797(JAK2) 102363504
CMK: 103177704(jak2) 103181975
CIN: 778659(jak)
SPU: 590852
APLC: 110989207
SKO: 102806862
DME: Dmel_CG1594(hop)
DER: 6551607
DPE: 6599164
DSI: Dsimw501_GD15992(Dsim_hop)
MDE: 101895610
AAG: 5576502
AME: 726002
BIM: 100745315
BTER: 100642307
SOC: 105202510
MPHA: 105833761
AEC: 105153063
ACEP: 105617857
PBAR: 105432888
HST: 105190877
DQU: 106749378
CFO: 105255224
LHU: 105677920
PGC: 109854546
OBO: 105276413
PCF: 106785826
NVI: 100118996
MDL: 103579492
TCA: 663273(Hop)
NVL: 108564018
BMOR: 101746320
PMAC: 106716494
PRAP: 110991623
HAW: 110376354
TNL: 113495033
API: 100167312
DNX: 107166020
ZNE: 110840562
FCD: 110850062
TUT: 107371028
DPTE: 113791031
CRG: 105333485
MYI: 110446410
LAK: 106165712
LSV: 111908021
SPAR: SPRG_04295
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Wallace TA, Sayeski PP
  Title
Jak2 tyrosine kinase: a mediator of both housekeeping and ligand-dependent gene expression?
  Journal
Cell Biochem Biophys 44:213-22 (2006)
DOI:10.1385/CBB:44:2:213
Reference
PMID:9618263
  Authors
Saltzman A, Stone M, Franks C, Searfoss G, Munro R, Jaye M, Ivashchenko Y
  Title
Cloning and characterization of human Jak-2 kinase: high mRNA expression in immune cells and muscle tissue.
  Journal
Biochem Biophys Res Commun 246:627-33 (1998)
DOI:10.1006/bbrc.1998.8685
  Sequence
[hsa:3717]

KEGG   ORTHOLOGY: K11218Help
Entry
K11218                      KO                                     

Name
JAK3
Definition
Janus kinase 3 [EC:2.7.10.2]
Pathway
ko04062  Chemokine signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04217  Necroptosis
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04630  JAK-STAT signaling pathway
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko05161  Hepatitis B
ko05162  Measles
ko05166  Human T-cell leukemia virus 1 infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05223  Non-small cell lung cancer
Module
M00684  JAK-STAT signaling
Disease
H00091  T-B+Severe combined immunodeficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 Jak-STAT signaling pathway
    K11218  JAK3; Janus kinase 3
   04151 PI3K-Akt signaling pathway
    K11218  JAK3; Janus kinase 3
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K11218  JAK3; Janus kinase 3
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K11218  JAK3; Janus kinase 3
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    K11218  JAK3; Janus kinase 3
   04659 Th17 cell differentiation
    K11218  JAK3; Janus kinase 3
   04062 Chemokine signaling pathway
    K11218  JAK3; Janus kinase 3
 09160 Human Diseases
  09161 Cancers: Overview
   05200 Pathways in cancer
    K11218  JAK3; Janus kinase 3
   05203 Viral carcinogenesis
    K11218  JAK3; Janus kinase 3
  09162 Cancers: Specific types
   05223 Non-small cell lung cancer
    K11218  JAK3; Janus kinase 3
  09172 Infectious diseases: Viral
   05166 Human T-cell leukemia virus 1 infection
    K11218  JAK3; Janus kinase 3
   05162 Measles
    K11218  JAK3; Janus kinase 3
   05161 Hepatitis B
    K11218  JAK3; Janus kinase 3
   05169 Epstein-Barr virus infection
    K11218  JAK3; Janus kinase 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K11218  JAK3; Janus kinase 3
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00684  JAK-STAT signaling
     K11218  JAK3; Janus kinase 3
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K11218  JAK3; Janus kinase 3
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   K11218  JAK3; Janus kinase 3
BRITE hierarchy
Other DBs
GO: 0004715
Genes
HSA: 3718(JAK3)
PPS: 100972035(JAK3)
GGO: 101153232(JAK3)
PON: 100433988(JAK3)
NLE: 100603367(JAK3)
MCC: 720040(JAK3)
MCF: 102134669(JAK3)
CSAB: 103234155(JAK3)
RRO: 104660959(JAK3)
RBB: 108534230(JAK3)
CJC: 100397491(JAK3)
SBQ: 101034707(JAK3)
MMU: 16453(Jak3)
RNO: 25326(Jak3)
CGE: 100773497(Jak3)
NGI: 103726892(Jak3)
HGL: 101715472(Jak3)
CCAN: 109698332(Jak3)
TUP: 102471949(JAK3)
CFA: 610004(JAK3)
AML: 100474005(JAK3)
UMR: 103675167(JAK3)
ORO: 101369142(JAK3)
FCA: 101092339(JAK3)
PTG: 102966280(JAK3)
AJU: 106969157(JAK3)
BTA: 538276(JAK3)
BOM: 102286011(JAK3)
BIU: 109561426(JAK3)
PHD: 102327649(JAK3)
CHX: 102171504(JAK3)
OAS: 101112816(JAK3)
SSC: 100518649(JAK3)
CFR: 102503866(JAK3)
CDK: 105101858(JAK3)
BACU: 103012385(JAK3)
LVE: 103081519(JAK3)
OOR: 101283171(JAK3)
ECB: 100147451(JAK3)
EPZ: 103542314(JAK3) 103542962
EAI: 106830858(JAK3)
MYB: 102241153(JAK3)
MYD: 102767426(JAK3)
HAI: 109382346(JAK3)
RSS: 109450092(JAK3)
PALE: 102898620(JAK3)
LAV: 100665896(JAK3)
TMU: 101345231
MDO: 100010720(JAK3)
SHR: 100920108(JAK3)
OAA: 100085612(JAK3)
GGA: 395845(JAK3)
MGP: 100544996(JAK3)
CJO: 107325427(JAK3)
GFR: 102039894(JAK3)
PHI: 102110608(JAK3)
PMAJ: 107199430
CCAE: 111940256
FPG: 101914306(JAK3)
FCH: 102054762(JAK3)
CLV: 102096086(JAK3)
NNI: 104013697(JAK3)
AAM: 106486617(JAK3)
ASN: 102382453(JAK3)
AMJ: 102570658(JAK3) 109286140
PSS: 102443764(JAK3)
CMY: 102943900(JAK3)
CPIC: 101946232(JAK3)
PVT: 110072505(JAK3)
PBI: 103062083(JAK3)
GJA: 107120632(JAK3)
XLA: 378531(jak3.L)
XTR: 100135373(jak3)
NPR: 108790798(JAK3)
SPAR: SPRG_12528
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8022790
  Authors
Kawamura M, McVicar DW, Johnston JA, Blake TB, Chen YQ, Lal BK, Lloyd AR, Kelvin DJ, Staples JE, Ortaldo JR, et al.
  Title
Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes.
  Journal
Proc Natl Acad Sci U S A 91:6374-8 (1994)
DOI:10.1073/pnas.91.14.6374
  Sequence
[hsa:3718]

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