KEGG ORTHOLOGY: K04448

ORTHOLOGY: K04448

Entry

K04448                      KO

Symbol

JUN

Name

transcription factor AP-1

Pathway

map01522

Endocrine resistance

map04010

MAPK signaling pathway

map04012

ErbB signaling pathway

map04013

MAPK signaling pathway - fly

map04024

cAMP signaling pathway

map04137

Mitophagy - animal

map04210

Apoptosis

map04214

Apoptosis - fly

map04310

Wnt signaling pathway

map04380

Osteoclast differentiation

map04510

Focal adhesion

map04530

Tight junction

map04620

Toll-like receptor signaling pathway

map04621

NOD-like receptor signaling pathway

map04624

Toll and Imd signaling pathway

map04625

C-type lectin receptor signaling pathway

map04657

IL-17 signaling pathway

map04658

Th1 and Th2 cell differentiation

map04659

Th17 cell differentiation

map04660

T cell receptor signaling pathway

map04662

B cell receptor signaling pathway

map04668

TNF signaling pathway

map04722

Neurotrophin signaling pathway

map04912

GnRH signaling pathway

map04915

Estrogen signaling pathway

map04921

Oxytocin signaling pathway

map04926

Relaxin signaling pathway

map04932

Non-alcoholic fatty liver disease

map04933

AGE-RAGE signaling pathway in diabetic complications

map05030

Cocaine addiction

map05031

Amphetamine addiction

map05120

Epithelial cell signaling in Helicobacter pylori infection

map05130

Pathogenic Escherichia coli infection

map05131

Shigellosis

map05132

Salmonella infection

map05133

Pertussis

map05135

Yersinia infection

map05140

Leishmaniasis

map05142

Chagas disease

map05161

Hepatitis B

map05162

Measles

map05166

Human T-cell leukemia virus 1 infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05171

Coronavirus disease - COVID-19

map05200

Pathways in cancer

map05203

Viral carcinogenesis

map05207

Chemical carcinogenesis - receptor activation

map05208

Chemical carcinogenesis - reactive oxygen species

map05210

Colorectal cancer

map05211

Renal cell carcinoma

map05224

Breast cancer

map05231

Choline metabolism in cancer

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

map05321

Inflammatory bowel disease

map05323

Rheumatoid arthritis

map05417

Lipid and atherosclerosis

map05418

Fluid shear stress and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04448  JUN; transcription factor AP-1
   04013 MAPK signaling pathway - fly
    K04448  JUN; transcription factor AP-1
   04012 ErbB signaling pathway
    K04448  JUN; transcription factor AP-1
   04310 Wnt signaling pathway
    K04448  JUN; transcription factor AP-1
   04668 TNF signaling pathway
    K04448  JUN; transcription factor AP-1
   04024 cAMP signaling pathway
    K04448  JUN; transcription factor AP-1
09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    K04448  JUN; transcription factor AP-1
  09143 Cell growth and death
   04210 Apoptosis
    K04448  JUN; transcription factor AP-1
   04214 Apoptosis - fly
    K04448  JUN; transcription factor AP-1
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04448  JUN; transcription factor AP-1
   04530 Tight junction
    K04448  JUN; transcription factor AP-1
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04448  JUN; transcription factor AP-1
   04624 Toll and Imd signaling pathway
    K04448  JUN; transcription factor AP-1
   04621 NOD-like receptor signaling pathway
    K04448  JUN; transcription factor AP-1
   04625 C-type lectin receptor signaling pathway
    K04448  JUN; transcription factor AP-1
   04660 T cell receptor signaling pathway
    K04448  JUN; transcription factor AP-1
   04658 Th1 and Th2 cell differentiation
    K04448  JUN; transcription factor AP-1
   04659 Th17 cell differentiation
    K04448  JUN; transcription factor AP-1
   04657 IL-17 signaling pathway
    K04448  JUN; transcription factor AP-1
   04662 B cell receptor signaling pathway
    K04448  JUN; transcription factor AP-1
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04448  JUN; transcription factor AP-1
   04915 Estrogen signaling pathway
    K04448  JUN; transcription factor AP-1
   04921 Oxytocin signaling pathway
    K04448  JUN; transcription factor AP-1
   04926 Relaxin signaling pathway
    K04448  JUN; transcription factor AP-1
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04448  JUN; transcription factor AP-1
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04448  JUN; transcription factor AP-1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04448  JUN; transcription factor AP-1
   05207 Chemical carcinogenesis - receptor activation
    K04448  JUN; transcription factor AP-1
   05208 Chemical carcinogenesis - reactive oxygen species
    K04448  JUN; transcription factor AP-1
   05203 Viral carcinogenesis
    K04448  JUN; transcription factor AP-1
   05231 Choline metabolism in cancer
    K04448  JUN; transcription factor AP-1
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04448  JUN; transcription factor AP-1
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04448  JUN; transcription factor AP-1
   05211 Renal cell carcinoma
    K04448  JUN; transcription factor AP-1
   05224 Breast cancer
    K04448  JUN; transcription factor AP-1
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04448  JUN; transcription factor AP-1
   05170 Human immunodeficiency virus 1 infection
    K04448  JUN; transcription factor AP-1
   05161 Hepatitis B
    K04448  JUN; transcription factor AP-1
   05171 Coronavirus disease - COVID-19
    K04448  JUN; transcription factor AP-1
   05162 Measles
    K04448  JUN; transcription factor AP-1
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04448  JUN; transcription factor AP-1
   05169 Epstein-Barr virus infection
    K04448  JUN; transcription factor AP-1
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04448  JUN; transcription factor AP-1
   05130 Pathogenic Escherichia coli infection
    K04448  JUN; transcription factor AP-1
   05132 Salmonella infection
    K04448  JUN; transcription factor AP-1
   05131 Shigellosis
    K04448  JUN; transcription factor AP-1
   05135 Yersinia infection
    K04448  JUN; transcription factor AP-1
   05133 Pertussis
    K04448  JUN; transcription factor AP-1
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K04448  JUN; transcription factor AP-1
   05142 Chagas disease
    K04448  JUN; transcription factor AP-1
  09163 Immune disease
   05323 Rheumatoid arthritis
    K04448  JUN; transcription factor AP-1
   05321 Inflammatory bowel disease
    K04448  JUN; transcription factor AP-1
  09165 Substance dependence
   05030 Cocaine addiction
    K04448  JUN; transcription factor AP-1
   05031 Amphetamine addiction
    K04448  JUN; transcription factor AP-1
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04448  JUN; transcription factor AP-1
   05418 Fluid shear stress and atherosclerosis
    K04448  JUN; transcription factor AP-1
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K04448  JUN; transcription factor AP-1
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04448  JUN; transcription factor AP-1
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K04448  JUN; transcription factor AP-1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04448  JUN; transcription factor AP-1
Transcription factors [BR:ko03000]
Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, Jun
    K04448  JUN; transcription factor AP-1

Genes

HSA:

3725(JUN)

PTR:	456893(JUN)

PPS:	100980908(JUN)

GGO:	101145729(JUN)

PON:	100450292(JUN)

PPYG:

129036837(JUN)

NLE:	100586501(JUN)

HMH:	116457363(JUN)

SSYN:

129458421(JUN)

MCC:	716452(JUN)

MCF:	102126446(JUN)

MTHB:

126962798

MNI:	105495146(JUN)

CSAB:

103224726(JUN)

CATY:

105595973(JUN)

PANU:

101010894(JUN)

TGE:	112619625(JUN)

MLEU:

105534921(JUN)

RRO:	104664278(JUN)

RBB:	108532921(JUN)

TFN:	117091985(JUN)

PTEH:

111523160(JUN)

CANG:

105511418(JUN)

CJC:	100400411(JUN)

SBQ:	101043809(JUN)

CIMI:

108314896(JUN)

ANAN:

105710356(JUN)

CSYR:

103274529(JUN)

MMUR:

105882585(JUN)

LCAT:

123635592(JUN)

PCOQ:

105806347(JUN)

OGA:	100965098(JUN)

MMU:	16476(Jun)

MCAL:

110292423(Jun)

MPAH:

110323252(Jun)

RNO:	24516(Jun)

MCOC:

116096245(Jun)

ANU:	117709069(Jun)

MUN:	110559727(Jun)

CGE:

113834001

MAUA:

101829259(Jun)

PROB:

127224952(Jun)

PLEU:

114693768(Jun)

MORG:

121448148(Jun)

MFOT:

126497948

AAMP:

119816694(Jun)

NGI:	103737138(Jun)

HGL:	101722197(Jun)

CPOC:

100728775(Jun)

CCAN:

109700777(Jun)

DSP:	122108943(Jun)

PLOP:

125355221(Jun)

NCAR:

124963740 124991717

MMMA:

107141712(Jun)

OCU:	100008856(JUN)

OPI:	101521685(JUN)

TUP:	102496870(JUN)

GVR:	103592390(JUN)

CFA:	609429(JUN)

CLUD:

112647115(JUN)

VVP:	112926091(JUN)

VLG:	121500205(JUN)

NPO:	129497811(JUN)

AML:	100483834(JUN)

UMR:	103670861(JUN)

UAH:	113254611(JUN)

UAR:	123795376(JUN)

ELK:

111143174

LLV:

125098159

MPUF:

101680348(JUN)

MNP:	132000935(JUN)

MLK:	131809019(JUN)

NVS:	122900023(JUN)

ORO:	101368207(JUN)

EJU:	114212152(JUN)

ZCA:	113939569(JUN)

MLX:	118019356(JUN)

NSU:	110575086(JUN)

LWW:	102727222(JUN)

FCA:	101097261(JUN)

PYU:	121027214(JUN)

PCOO:

112872218(JUN)

PBG:	122480569(JUN)

PVIV:

125173215(JUN)

LRUF:

124516273

PTG:	102958666(JUN)

PPAD:

109266785(JUN)

PUC:

125912547

AJU:

106974986

HHV:	120236252(JUN)

BTA:	280831(JUN)

BOM:	102267895(JUN)

BIU:	109556235(JUN)

BBUB:

102405224(JUN)

BBIS:

105000175(JUN)

CHX:	102185423(JUN)

OAS:	443219(JUN)

BTAX:

128044447(JUN)

ODA:	120857086(JUN)

CCAD:

122436906(JUN)

MBEZ:

129540610(JUN)

SSC:	396913(JUN)

CFR:	102516943(JUN)

CBAI:

105071674(JUN)

CDK:	105092850(JUN)

VPC:	102541687(JUN)

BACU:

103001311 103014668

BMUS:

118901549(JUN)

LVE:	103071861(JUN)

OOR:	101288913(JUN)

DLE:	111175871(JUN)

PCAD:

102975458(JUN)

PSIU:

116761115(JUN)

NASI:

112407080(JUN)

ECB:	100067469(JUN)

EAI:	106833477(JUN)

MYB:	102260808(JUN)

MYD:	102752693(JUN) 107183844(JUNB)

MMYO:

118676104(JUN)

MLF:	102437415(JUN)

MDT:	132231012(JUN)

PKL:	118722794(JUN)

EFUS:

103284067(JUN)

MNA:	107536966(JUN)

DRO:	112314642(JUN)

SHON:

118984936(JUN)

AJM:	119051654(JUN)

PDIC:

114496428(JUN)

PHAS:

123831409(JUN)

MMF:	118627223(JUN)

PPAM:

129070771(JUN)

HAI:	109371251(JUN) 109371257

RFQ:	117027175(JUN)

PALE:

102896121(JUN)

PGIG:

120621837(JUN)

PVP:	105303436(JUN)

RAY:	107518352(JUN)

MJV:	108386817(JUN)

TOD:	119235421(JUN)

SETR:

126010979(JUN)

LAV:	100670432(JUN)

TMU:

101361653

ETF:	101656959(JUN)

DNM:	101412001(JUN)

MDO:	100018774(JUN)

GAS:	123247656(JUN)

SHR:	116423739(JUN)

AFZ:

127563247

PCW:	110212948(JUN)

TVP:	118848940(JUN)

GGA:	424673(JUN)

PCOC:

116235320(JUN)

MGP:	100548501(JUN)

CJO:	107317693(JUN)

TPAI:

128072448(JUN)

LMUT:

125693900(JUN)

NMEL:

110402812(JUN)

APLA:

101796626(JUN)

ACYG:

106032923(JUN)

CATA:

118243795(JUN)

AFUL:

116492142(JUN)

TGU:	100229914(JUN)

LSR:	110476957(JUN)

SCAN:

103815057(JUN)

PMOA:

120503126(JUN)

OTC:	121345151(JUN)

PRUF:

121361966(JUN)

GFR:	102039078(JUN)

FAB:	101816255(JUN)

OMA:	130256017(JUN)

PHI:	102112236(JUN)

PMAJ:

107208073(JUN)

CCAE:

111932998(JUN)

CCW:	104695158(JUN)

CBRC:

103615058(JUN)

ETL:	114055179(JUN)

ZAB:	102064401(JUN)

ZLE:	135451182(JUN)

SVG:	106849741(JUN)

MMEA:

130576048(JUN)

HRT:	120756728 120756742

SATI:

136365098(JUN)

FPG:	101918818(JUN)

FCH:	102050406(JUN)

CCRI:

104166894(JUN)

NNT:	104401428(JUN)

SHAB:

115611576(JUN)

ACUN:

113482645(JUN)

TALA:

104356824(JUN)

ACHC:

115348746(JUN)

HALD:

104312836(JUN)

HLE:	104840987(JUN)

AGEN:

126041649

GCL:

127019308

CSTI:

104562831(JUN)

LDI:	104348545(JUN)

MNB:	103782384(JUN)

DPUB:

104301752(JUN)

AVIT:

104275215(JUN)

BRHI:

104496282(JUN)

EGZ:	104123944(JUN)

NNI:	104009262(JUN)

PCRI:

104026787(JUN)

PCAO:

104042855(JUN)

PADL:

103913320(JUN)

AFOR:

103905662(JUN)

FGA:	104072374(JUN)

GSTE:

104253202(JUN)

CLV:	102092209(JUN)

MUI:	104535854(JUN)

PGUU:

104462033(JUN)

PLET:

104622363(JUN)

EHS:	104505549(JUN)

CMAC:

104478878(JUND)

CUCA:

104066542(JUN)

TEO:

104371575

BREG:

104636702(JUN)

OHA:	104328027(JUN)

ACAR:

104520248(JUN)

CPEA:

104385160(JUN)

CVF:	104286046(JUN)

RTD:	128913682(JUN)

AAM:	106494500(JUN)

AROW:

112967663(JUN)

NPD:	112943557(JUN)

TGT:	104568780(JUN)

DNE:	112986058(JUN)

SCAM:

104152786(JUN)

ASN:	102374896(JUN)

AMJ:	102566064(JUN)

CPOO:

109307535(JUN)

GGN:	109286591(JUN)

PSS:	102455008(JUN)

CMY:	102937264(JUN)

CCAY:

125641435(JUN)

DCC:	119860735(JUN)

CPIC:

101930786(JUN)

TST:	117881919(JUN)

CABI:

116838113(JUN)

MRV:	120370011(JUN)

ACS:	100567718(jun)

ASAO:

132773982(JUN)

PVT:	110077124(JUN)

SUND:

121928905(JUN)

PBI:	103057921(JUN)

PMUR:

107302456(JUN)

CTIG:

120297354(JUN)

TSR:	106545185(JUN)

PGUT:

117664293(JUN)

APRI:

131193919(JUN)

PTEX:

113440637(JUN)

NSS:	113411064(JUN)

VKO:	123023503(JUN)

PMUA:

114598927(JUN)

PRAF:

128415701(JUN)

ZVI:	118089100(JUN)

HCG:	128324617(JUN)

GJA:	107111867(JUN)

STOW:

125433193(JUN)

EMC:	129329820(JUN)

XLA:	108700666 379050(jun.S) 399400(jun.L)

XTR:	100493911(jun)

NPR:	108788164(JUN)

RTEM:

120946091(JUN)

BBUF:

120979042(JUN)

BGAR:

122943208(JUN)

MUO:	115472249(JUN)

GSH:	117346700(JUN)

DRE:	335916(jun)

SRX:	107712863 107721038 107735627 107739852

SANH:

107669151(jun) 107682222 107684195 107687249

SGH:	107563389 107581481 107597804

CCAR:

109096570 109113360 109113363

CAUA:

113063047 113069861 113070627 113121148

CGIB:

127938846 127957333 127966190 127984344

PTET:

122324581(jun) 122344965(june)

LROH:

127165315(june) 127183046(jun)

OMC:	131527636(jun) 131540839(june)

PPRM:

120471668(june) 120493498(jun)

RKG:	130076949(june) 130096106(jun)

MAMB:

125266201(june) 125279071(jun)

CIDE:

127502688 127513691

CERY:

137019377(jun)

MASI:

127410395 127416105 127423532 127433363

TROS:

130545711(june) 130565747(jun)

TDW:	130420161(june) 130434107(jun)

MANU:

129429389(jun) 129439457(june)

IPU:	108258130(jun) 108260086(june) 108267848

IFU:	128601161(jun) 128603833(june) 128610446

PHYP:

113531319 113545334 113547281

SMEO:

124377376(jun) 124378958(june) 124387939

TFD:	113641221(june) 113658727(jun) 113662252

TVC:	132841102(june) 132843425(jun) 132849017

TRN:	134303335(june) 134312443 134320007(jun)

AMEX:

103021920(june) 103026868(jun)

CMAO:

118814879(june) 118815433(jun)

EEE:	113568701 113582834 113589106

CHAR:

105891385 105902506(june) 122131950(jun)

TRU:	101064806(jun) 101077059

TFS:	130517429(june) 130529159(jun) 130538932

TNG:	GSTEN00013845G001 GSTEN00015028G001 GSTEN00020512G001

LCO:	104926010 104927418(jun) 104937023

NCC:	104962417 104964063(jun) 104967900

TBEN:

117474460(june) 117488775 117496095(jun)

CGOB:

115007435 115016821 115022963(jun)

PGEO:

117445372(jun) 117455908(june) 117462217

GACU:

117545557 117555214(jun) 117557427(june)

EMAC:

134866042 134868643(june) 134869936(jun)

ELY:	117253294(jun) 117269419(june) 117271897

EFO:	125895951(jun) 125902348 125906209(june)

PLEP:

121951914 121960294(june) 121963101(jun)

SLUC:

116041404(june) 116045703 116058852(jun)

ECRA:

117949980(jun) 117953876 117959572(june)

ESP:	116677748 116695201 116698745 116704060

PFLV:

114561902 114566085(jun) 114571404

GAT:	120815715 120824340(jun) 120831506(june)

PPUG:

119209630 119217222(jun) 119226243(june)

AFB:	129094375(jun) 129102849(june) 129110677

CLUM:

117740649(june) 117746578(jun)

PSWI:

130194485(jun) 130197944

MSAM:

119901002(jun) 119902398 119915034(june)

SCHU:

122865896(june) 122878280(jun) 122887568

CUD:	121512795(jun) 121520730 121524721(june)

ALAT:

119010619 119029038(jun) 119029448(june)

MZE:	101463670 101472459 101486839(jun)

ONL:	100703685 100705884 100707786

OAU:	116314808 116331225(jun) 116334108(june)

OLA:	101160956 101173011(jun) 101174822

OML:	112144196(june) 112147409 112150898(jun)

CSAI:

133451783 133452308 133453062 133458200(jun)

XMA:	102230050(jun) 102234665

XCO:	114145916(jun) 114151264

XHE:	116721147(jun) 116724071 116725965

PRET:

103463760 103478989(jun)

PFOR:

103137045 103140033(jun) 103153938

PLAI:

106947718(jun) 106954325 106956726

PMEI:

106919032 106920852(jun) 106924591

GAF:	122819303(june) 122839073(jun) 122841430

PPRL:

129355050 129361914 129378374(jun)

CVG:	107083648(jun) 107095895

CTUL:

119772327 119778327(june) 119799267(jun)

GMU:	124870122 124873148(june) 124873314(jun)

NFU:	107384375(jun) 107396464

KMR:	108230559(jun) 108238338

ALIM:

106521291(jun) 106534447

NWH:	119408007(jun) 119414431

AOCE:

111577530 111587627(jun)

MCEP:

124996826(junE) 125009453(jun) 125010340

CSEM:

103376719(jun) 103398819

POV:	109625845 109643961(jun)

SSEN:

122758027(june) 122762117(jun) 122770217

HHIP:

117760139(jun) 117771428 117771429 117778239

HSP:	118117519 118121433(jun) 118125425(june)

PPLT:

128424504(june) 128444021 128448630(jun) 128454069

SMAU:

118285340(june) 118310771 118317957(jun)

LCF:	108879142(jun) 108883834

SDU:	111228982(jun) 111231968

SLAL:

111648134 111666541(jun) 111671973

XGL:	120791293(jun) 120799405

HCQ:	109521335 109532403

SSCV:

125976226 125979215 125984729

SBIA:

133491200(june) 133503311(jun) 133510484

PEE:	133406080(jun) 133411290 133413725(june)

PTAO:

133465148(june) 133481114(jun) 133488582

BPEC:

110154702(jun) 110173458

MALB:

109952420 109970646(jun)

BSPL:

114844877 114854282(jun) 114867319(june)

SJO:	128362425(jun) 128368559 128380084(june)

SASA:

106568560 106569413 106572830 106584280(JUN) 106600411(jun) 106613963(JUN)

STRU:

115149542 115157247 115158459 115160168 115169534 115192441

OTW:	112219784 112226753 112248681(jun) 112251077 112257314(june) 112260691

OMY:	100136112 110508530 110521616 110523115 110530532 110536876(june)

OGO:	123996484 124000557 124009605 124037840 124041708 124047982

ONE:	115102911 115108486 115114614 115128074 115145482

OKI:	109871765 109874843 109881432 109884854 109897984 109902677

OKE:	118359083(jun) 118375408 118387243 118391743(june) 118391906 118394851

SALP:

111956675 111972264 111975849 111979459 112074546 112075772

SNH:	120020236 120026472 120036885 120052552 120054896 120056039

CCLU:

121533346 121535574 121539880 121573366 121581081 121583151

ELS:	105011734 105020506 105022094(jun)

SFM:	108923530 108935116(jun) 114911311

PKI:	111834818 111842196 111847550

AANG:

118212138(june) 118226519(jun)

LOC:	102689161 102693762(jun)

PSPA:

121303585 121314498 121327132 121330935

ARUT:

117401403 117416589 117421449 117963780

PSEX:

120514504(jun) 120533062(june)

LCM:	102350279(JUN) 102358101

CMK:	103185297(jun)

RTP:	109925743(jun)

CPLA:

122554377(jun)

HOC:	132818750(jun)

LERI:

129700980(jun)

PMRN:

116938655 116948823 116951855

LRJ:	133346493 133352083

BFO:

118431712

BBEL:

109475262

CIN:	778972(jun)

SCLV:

120347297

SPU:	115918562 588294

LPIC:

APLC:

ARUN:

AJC:

SKO:

DME:	Dmel_CG2275(Jra)

DER:

6541513

DSE:

6608460

DSI:	Dsimw501_GD15385(Dsim_GD15385)

DYA:	Dyak_GE19337

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI20534

DAZ:

108617394

DNV:

108654006

DHE:	111593729 115483446

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ000084

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105671646(Jra)

PGC:

109856529

OBO:

105277703

PCF:	106790673 106790674

PFUC:

122525592 122525603

VPS:	122633432 122633433

VCRB:

124429376 124429377

VVE:	124953637 124953638

NVI:

CSOL:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	663937(Jra)

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

API:	100160348 100161138

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106689606(Jra) 106691817

NLU:	111054665 111060186

MQU:	128996756 128997026

PHU:	Phum_PHUM379500

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_306002

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

MNZ:

EAF:

LSM:	121118904 121123393

TCF:	131890280 131891744

PPOI:

119112496

DSV:	119433255 119433258

RSAN:

119376885 119405748 119405750 119405752

RMP:	119180583 119180758 119181604 119186342

VDE:

VJA:

TUT:

DPTE:

CSCU:

CVS:	136969078 136984534

PTEP:

107448970 107454471

ABRU:

129963484 129988621

UDV:	129221401 129225693

SDM:	118179866 118183384

LPOL:

106461722 106466955 106467336 106470565 106475369 106477746

PMEO:

129599870

BMY:	BM_BM5997(Bma-jun-1)

LOA:	LOAG_16739

TSP:	Tsp_05337 Tsp_05339

HRO:	HELRODRAFT_115827 HELRODRAFT_170243

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MYI:	110463540 110463541

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:	5505701 5516132 5518487 5521019

EPA:	110236685 110239358 110248330

ATEN:

116290086 116293414 116296388

ADF:	107336656 107348109

AMIL:

114963836 114971755 114976904

PDAM:

113665429 113681226 113683358

SPIS:

111324065 111328212 111345067

DGT:	114535859 114542465

XEN:	124433339 124444547 124453684

HMG:	100204820(jun) 105851038

RES:

135689783

TAD:	TRIADDRAFT_64084

AQU:

100640297

FFU:	CLAFUR5_04119

TET:	TTHERM_00703450

» show all

Reference

PMID:26098572

Authors

Liu J, Han Q, Peng T, Peng M, Wei B, Li D, Wang X, Yu S, Yang J, Cao S, Huang K, Hutchins AP, Liu H, Kuang J, Zhou Z, Chen J, Wu H, Guo L, Chen Y, Chen Y, Li X, Wu H, Liao B, He W, Song H, Yao H, Pan G, Chen J, Pei D

Title

The oncogene c-Jun impedes somatic cell reprogramming.

Journal

Nat Cell Biol 17:856-67 (2015)
DOI:10.1038/ncb3193

Reference

PMID:3194415

Authors

Hattori K, Angel P, Le Beau MM, Karin M

Title

Structure and chromosomal localization of the functional intronless human JUN protooncogene.

Journal

Proc Natl Acad Sci U S A 85:9148-52 (1988)
DOI:10.1073/pnas.85.23.9148

Sequence

[hsa:3725]

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (118)   
   KEGG PATHWAY (118)   
Gene (3373)   
   KEGG GENES (950)   
   KEGG MGENES (83)   
   RefGene (2336)   
   OC (4)   
Literature (2)   
   PubMed (2)   
All databases (3495)   

Download RDF

ORTHOLOGY: K04684

Entry

K04684                      KO

Symbol

SP1

Name

transcription factor Sp1

Pathway

map01522

Endocrine resistance

map04137

Mitophagy - animal

map04350

TGF-beta signaling pathway

map04915

Estrogen signaling pathway

map04927

Cortisol synthesis and secretion

map04928

Parathyroid hormone synthesis, secretion and action

map04934

Cushing syndrome

map05016

Huntington disease

map05017

Spinocerebellar ataxia

map05163

Human cytomegalovirus infection

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05224

Breast cancer

map05231

Choline metabolism in cancer

map05415

Diabetic cardiomyopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    K04684  SP1; transcription factor Sp1
09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    K04684  SP1; transcription factor Sp1
09150 Organismal Systems
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K04684  SP1; transcription factor Sp1
   04928 Parathyroid hormone synthesis, secretion and action
    K04684  SP1; transcription factor Sp1
   04927 Cortisol synthesis and secretion
    K04684  SP1; transcription factor Sp1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04684  SP1; transcription factor Sp1
   05202 Transcriptional misregulation in cancer
    K04684  SP1; transcription factor Sp1
   05231 Choline metabolism in cancer
    K04684  SP1; transcription factor Sp1
  09162 Cancer: specific types
   05224 Breast cancer
    K04684  SP1; transcription factor Sp1
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K04684  SP1; transcription factor Sp1
  09164 Neurodegenerative disease
   05016 Huntington disease
    K04684  SP1; transcription factor Sp1
   05017 Spinocerebellar ataxia
    K04684  SP1; transcription factor Sp1
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K04684  SP1; transcription factor Sp1
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04684  SP1; transcription factor Sp1
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K04684  SP1; transcription factor Sp1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04684  SP1; transcription factor Sp1
   03029 Mitochondrial biogenesis
    K04684  SP1; transcription factor Sp1
Transcription factors [BR:ko03000]
Eukaryotic type
  Zinc finger
   Cys2His2 SP/KLF family and related proteins
    K04684  SP1; transcription factor Sp1
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Ubiquitas transcription factors
    K04684  SP1; transcription factor Sp1

Genes

HSA:

6667(SP1)

PTR:	451939(SP1)

PPS:	100985203(SP1)

GGO:	129525695(SP1)

PON:	100440745(SP1)

PPYG:

129009680(SP1)

NLE:	100585963(SP1)

HMH:	116481003(SP1)

SSYN:

129466125(SP1)

MCC:	702710(SP1)

MCF:	102115996(SP1)

MTHB:

126931105

MNI:	105474275(SP1)

CSAB:

103238395(SP1)

CATY:

105580268(SP1)

PANU:

116268873(SP1)

TGE:	112634626(SP1)

MLEU:

105554908(SP1)

RRO:	104670595(SP1)

RBB:	108521535(SP1)

TFN:	117090035(SP1)

PTEH:

111541933

CANG:

105503673(SP1)

CJC:	100407824(SP1)

SBQ:	101048381(SP1)

CIMI:

108284876(SP1)

ANAN:

105715866(SP1)

CSYR:

103260226

MMUR:

105870777(SP1)

LCAT:

123639764(SP1)

PCOQ:

105818043(SP1)

OGA:	100953042(SP1)

MMU:	20683(Sp1)

MCAL:

110310111(Sp1)

MPAH:

110334488(Sp1)

RNO:	24790(Sp1)

MCOC:

116080468(Sp1)

ANU:	117718542(Sp1)

MUN:	110552322(Sp1)

CGE:	100767199(Sp1)

MAUA:

101842935(Sp1)

PROB:

127226146(Sp1)

PLEU:

114696625(Sp1)

MORG:

121444220 121459388

MFOT:

126491183

AAMP:

119823260(Sp1)

NGI:	103738561(Sp1)

HGL:	101697506(Sp1)

CPOC:

100726500(Sp1)

CCAN:

109684073(Sp1)

DORD:

105997935(Sp1)

DSP:	122124412(Sp1)

PLOP:

125364008(Sp1)

NCAR:

124962851 124983225

MMMA:

107148811(Sp1)

OCU:

100351317

OPI:	101533630(SP1)

TUP:	102473003(SP1)

GVR:	103592813(SP1)

CFA:	486507(SP1)

CLUD:

112667184(SP1)

VVP:	112921180(SP1)

VLG:	121479904(SP1)

NPO:	129517345(SP1)

AML:	100474983(SP1)

UMR:	103675530(SP1)

UAR:	123794698(SP1)

ELK:

111157856

LLV:

125106436

MPUF:

101686835(SP1)

MNP:	132019731(SP1)

MLK:	131838694(SP1)

NVS:	122892412(SP1)

ORO:	101367562(SP1)

EJU:	114225869(SP1)

ZCA:	113921297(SP1)

MLX:	118008792(SP1)

NSU:	110577393(SP1)

LWW:	102750952(SP1)

FCA:	101100227(SP1)

PYU:	121038490(SP1)

PCOO:

112867279(SP1)

PBG:	122473480(SP1)

PVIV:

125169758(SP1)

LRUF:

124502539

PTG:	102955984(SP1)

PPAD:

109249199(SP1)

PUC:

125919123

AJU:

106983094

HHV:	120247236(SP1)

BTA:	540741(SP1)

BOM:	102282294(SP1)

BIU:	109559035(SP1)

BBUB:

102392142(SP1)

BBIS:

105001581(SP1)

CHX:	100860911(SP1)

OAS:	101104139(SP1)

BTAX:

128047386(SP1)

ODA:	120858300(SP1)

CCAD:

122427132(SP1)

MBEZ:

129535764(SP1)

SSC:	396575(SP1)

CFR:	102520683(SP1)

CBAI:

105076285(SP1)

CDK:	105094564(SP1)

VPC:	102540803(SP1)

BACU:

103010578(SP1)

BMUS:

118901868(SP1)

OOR:	101284508(SP1)

DLE:	111173942(SP1)

PCAD:

102973166(SP1)

PSIU:

116760263(SP1)

NASI:

112394040(SP1)

ECB:	100629527(SP1)

EPZ:	103559402(SP1)

EAI:	106835289(SP1)

MYB:	102256096(SP1)

MYD:	102752526(SP1) 102753263

MMYO:

118650196(SP1)

MLF:	102419937(SP1)

MDT:	132227671(SP1)

PKL:	118728518(SP1)

EFUS:

103285347(SP1)

MNA:	107528307(SP1)

DRO:	112318338(SP1)

AJM:	119043517(SP1)

PDIC:

114513239(SP1)

PHAS:

123812402(SP1)

MMF:	118623453(SP1)

PPAM:

129084812(SP1)

HAI:	109391846(SP1)

RFQ:	117028359(SP1)

PALE:

102894100(SP1)

PGIG:

120602177(SP1)

PVP:	105302655(SP1)

RAY:	107509855(SP1)

MJV:	108394782(SP1)

TOD:	119247989(SP1)

SARA:

101550205(SP1)

SETR:

126022125(SP1)

LAV:	100662543(SP1)

TMU:

101349790

ETF:	101656971(SP1)

DNM:	101441960(SP1)

GAS:	123250447(SP1)

SHR:	100930024(SP1)

AFZ:

127539187

PCW:	110194006(SP1)

TVP:	118849909(SP1)

OAA:	114814764(SP1)

GGA:	395303(SP1)

PCOC:

116234959(SP1)

MGP:	100539328(SP1)

CJO:	107306967(SP1)

NMEL:

110390879(SP1)

ACYG:

106049581(SP1)

CATA:

118261637(SP1)

TGU:	115491349(SP1)

LSR:	110480534(SP1)

SCAN:

103825226(SP1)

PMOA:

120501829(SP1)

OTC:	121335576(SP1)

PRUF:

121356081(SP1)

FAB:	101818755(SP1)

OMA:	130265886(SP1)

PHI:	102112711(SP1)

PMAJ:

107198749(SP1)

CCAE:

111940460(SP1)

CBRC:

103620426(SP1)

ETL:	114072464(SP1)

ZLE:	135459071(SP1)

SVG:	106863620(SP1)

MMEA:

130586745(SP1)

HRT:	120764517(SP1)

SATI:

136372758(SP1)

FPG:	101921378(SP1)

FCH:	102046473(SP1)

CCRI:

104158086(SP1)

SHAB:

115618625(SP1)

ACUN:

113490686(SP1)

ACHC:

115350863(SP1)

HALD:

104320978(SP1)

HLE:	104830278(SP1)

AGEN:

126046439

CSTI:

104555928(SP1)

LDI:	104339751(SP1)

DPUB:

104309612(SP1)

EGZ:	104124794(SP1)

NNI:	104017530(SP1)

PADL:

103925632(SP1)

AFOR:

103898173(SP1)

FGA:	104074723(SP1)

GSTE:

104262017

CLV:	102091713(SP1)

MUI:	104541243(SP1)

PGUU:

104465949

PLET:

104619218(SP1)

CUCA:

104055651(SP1)

TEO:	104374672(SP1)

BREG:

104631946(SP1)

CPEA:

104397440(SP1)

RTD:	128903816(SP1)

AAM:	106487505(SP1)

AROW:

112961692(SP1)

NPD:	112952281(SP1)

DNE:	112996339(SP1)

SCAM:

104145526(SP1)

ASN:	102370562(SP1)

AMJ:	102557884(SP1)

CPOO:

109323220(SP1)

PSS:	102450768(SP1)

CMY:	102943070(SP1)

CCAY:

125627418(SP1)

DCC:	119845757(SP1)

CPIC:

101949432(SP1)

TST:	117888449(SP1)

CABI:

116828475(SP1)

MRV:	120391068(SP1)

ACS:	100553756(sp1)

ASAO:

132767660(SP1)

PVT:	110074383(SP1)

SUND:

121921686(SP1)

PBI:	103052107(SP1)

PMUR:

107291239(SP1)

CTIG:

120309973(SP1)

TSR:	106552859(SP1)

PGUT:

117662667(SP1)

APRI:

131189583(SP1)

PTEX:

113445573(SP1)

NSS:	113418432(SP1)

VKO:	123029773(SP1)

PMUA:

114593046(SP1)

PRAF:

128406725(SP1)

ZVI:	118077160(SP1)

HCG:	128342787(SP1)

GJA:	107119663(SP1)

EMC:	129346042(SP1)

XLA:	108709905(sp1.S) 431939(sp1.L)

XTR:	394744(sp1)

NPR:	108786826(SP1)

RTEM:

120929328(SP1)

BBUF:

120996097(SP1)

BGAR:

122930637(SP1)

MUO:	115466821(SP1)

GSH:	117357473(SP1)

DRE:	324109(sp1)

SRX:	107742020(sp1) 107748519

SANH:

107663256 107690773

SGH:

107575074

CCAR:

109055633 109082561

CAUA:

113068116(sp1)

CGIB:

127967798

PTET:

122332822(sp1)

LROH:

127173298(sp1)

OMC:	131549245(sp1)

PPRM:

120483641(sp1)

RKG:	130086272(sp1)

MAMB:

125256370(sp1)

CIDE:

127522541

CERY:

137021797(sp1)

MASI:

127426577 127428316

TROS:

130549521(sp1)

TDW:	130410424(sp1)

MANU:

129427237(sp1)

IPU:

108254785

IFU:	128624771(sp1)

PHYP:

113524457(sp1)

SMEO:

124402225(sp1)

TFD:	113643964(sp1)

TVC:	132838110(sp1)

TRN:	134301990(sp1)

AMEX:

103027197(sp1)

CMAO:

118799824(sp1)

EEE:	113581441(sp1)

CHAR:

105900246(sp1)

TRU:	101071233(sp1)

TFS:	130523796(sp1)

TNG:	GSTEN00013587G001

LCO:	104919961(sp1)

NCC:

104962038

TBEN:

117489446(sp1)

CGOB:

115008146(sp1)

PGEO:

117446848(sp1)

GACU:

117534246(sp1)

EMAC:

134883063(sp1)

ELY:	117256362(sp1)

EFO:	125898073(sp1)

PLEP:

121957297(sp1)

SLUC:

116051354(sp1)

ECRA:

117943581(sp1)

ESP:	116688600(sp1)

PFLV:

114554650(sp1)

GAT:	120835455(sp1)

PPUG:

119229581(sp1)

AFB:	129106444(sp1)

CLUM:

117731360(sp1)

PSWI:

130208812(sp1)

MSAM:

119885812(sp1)

SCHU:

122863200(sp1)

CUD:	121507071(sp1)

ALAT:

119020987(sp1)

MZE:	101477446(sp1)

ONL:	100690316(sp1)

OAU:	116320762(sp1)

OLA:	101161549(sp1)

OML:	112144742(sp1)

CSAI:

133448301(sp1)

XMA:	102236306(sp1)

XCO:	114134954(sp1)

XHE:	116710631(sp1)

PRET:

103464412(sp1)

PFOR:

103135891(sp1)

PLAI:

106956674(sp1)

PMEI:

106928483(sp1)

GAF:	122833402(sp1)

PPRL:

129355044(sp1)

CVG:	107103259(sp1)

CTUL:

119789679(sp1)

GMU:	124857569(sp1)

NFU:	107385320(sp1)

KMR:	108231465(sp1)

ALIM:

106514730(sp1)

NWH:	119411843(sp1)

AOCE:

111583780(sp1)

MCEP:

125006195(sp1)

CSEM:

103386384(sp1)

POV:	109635527(sp1)

SSEN:

122768811(sp1)

HHIP:

117761907(sp1)

HSP:	118105456(sp1)

PPLT:

128448542(sp1)

SMAU:

118309364(sp1)

LCF:

108884839

SDU:	111224016(sp1)

SLAL:

111670201(sp1)

XGL:	120807114(sp1)

HCQ:	109510616(sp1)

SSCV:

125977882

SBIA:

133507592(sp1)

PEE:	133408879(sp1)

PTAO:

133483239(sp1)

BPEC:

110171184(sp1)

MALB:

109959387(sp1)

BSPL:

114855393(sp1)

SJO:	128355965(sp1)

SASA:

106566174(sp1)

STRU:

115207322(sp1)

OTW:	112235852(sp1)

OMY:	110494799(sp1)

OGO:	124002635(sp1)

ONE:	115117400(sp1)

OKI:	109899785(sp1)

OKE:	118374681(sp1)

SALP:

112069701(sp1)

SNH:	120057948(sp1)

CCLU:

121574801(sp1)

ELS:	105031425(sp1)

SFM:	108928412(sp1)

PKI:	111835274(sp1)

AANG:

118208449 118211736(sp1)

LOC:

102682631

PSPA:

121308931(sp1)

ARUT:

117401144 117966968

PSEX:

120524944

LCM:	102366212(SP1)

CMK:

103190683

LERI:

129694994

TPRE:

106650949

MBR:	MONBRDRAFT_37070(CI)

» show all

Reference

PMID:21798247

Authors

Infantino V, Convertini P, Iacobazzi F, Pisano I, Scarcia P, Iacobazzi V

Title

Identification of a novel Sp1 splice variant as a strong transcriptional activator.

Journal

Biochem Biophys Res Commun 412:86-91 (2011)
DOI:10.1016/j.bbrc.2011.07.047

Sequence

[hsa:6667]

Reference

PMID:10391891

Authors

Ding H, Benotmane AM, Suske G, Collen D, Belayew A

Title

Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene.

Journal

J Biol Chem 274:19573-80 (1999)
DOI:10.1074/jbc.274.28.19573

Sequence

[hsa:6667]

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (30)   
   KEGG PATHWAY (30)   
Drug (1)   
   KEGG DRUG (1)   
Gene (705)   
   KEGG GENES (379)   
   KEGG MGENES (162)   
   RefGene (162)   
   OC (2)   
Literature (2)   
   PubMed (2)   
All databases (741)   

Download RDF

ORTHOLOGY: K04379

Entry

K04379                      KO

Symbol

FOS

Name

proto-oncogene protein c-fos

Pathway

map01522

Endocrine resistance

map04010

MAPK signaling pathway

map04024

cAMP signaling pathway

map04210

Apoptosis

map04380

Osteoclast differentiation

map04620

Toll-like receptor signaling pathway

map04657

IL-17 signaling pathway

map04658

Th1 and Th2 cell differentiation

map04659

Th17 cell differentiation

map04660

T cell receptor signaling pathway

map04662

B cell receptor signaling pathway

map04668

TNF signaling pathway

map04713

Circadian entrainment

map04725

Cholinergic synapse

map04728

Dopaminergic synapse

map04915

Estrogen signaling pathway

map04917

Prolactin signaling pathway

map04921

Oxytocin signaling pathway

map04926

Relaxin signaling pathway

map04928

Parathyroid hormone synthesis, secretion and action

map04932

Non-alcoholic fatty liver disease

map04935

Growth hormone synthesis, secretion and action

map05031

Amphetamine addiction

map05130

Pathogenic Escherichia coli infection

map05132

Salmonella infection

map05133

Pertussis

map05135

Yersinia infection

map05140

Leishmaniasis

map05142

Chagas disease

map05161

Hepatitis B

map05162

Measles

map05166

Human T-cell leukemia virus 1 infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05170

Human immunodeficiency virus 1 infection

map05171

Coronavirus disease - COVID-19

map05200

Pathways in cancer

map05207

Chemical carcinogenesis - receptor activation

map05208

Chemical carcinogenesis - reactive oxygen species

map05210

Colorectal cancer

map05224

Breast cancer

map05231

Choline metabolism in cancer

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

map05323

Rheumatoid arthritis

map05417

Lipid and atherosclerosis

map05418

Fluid shear stress and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04379  FOS; proto-oncogene protein c-fos
   04668 TNF signaling pathway
    K04379  FOS; proto-oncogene protein c-fos
   04024 cAMP signaling pathway
    K04379  FOS; proto-oncogene protein c-fos
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04379  FOS; proto-oncogene protein c-fos
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04379  FOS; proto-oncogene protein c-fos
   04660 T cell receptor signaling pathway
    K04379  FOS; proto-oncogene protein c-fos
   04658 Th1 and Th2 cell differentiation
    K04379  FOS; proto-oncogene protein c-fos
   04659 Th17 cell differentiation
    K04379  FOS; proto-oncogene protein c-fos
   04657 IL-17 signaling pathway
    K04379  FOS; proto-oncogene protein c-fos
   04662 B cell receptor signaling pathway
    K04379  FOS; proto-oncogene protein c-fos
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K04379  FOS; proto-oncogene protein c-fos
   04917 Prolactin signaling pathway
    K04379  FOS; proto-oncogene protein c-fos
   04921 Oxytocin signaling pathway
    K04379  FOS; proto-oncogene protein c-fos
   04926 Relaxin signaling pathway
    K04379  FOS; proto-oncogene protein c-fos
   04935 Growth hormone synthesis, secretion and action
    K04379  FOS; proto-oncogene protein c-fos
   04928 Parathyroid hormone synthesis, secretion and action
    K04379  FOS; proto-oncogene protein c-fos
  09156 Nervous system
   04725 Cholinergic synapse
    K04379  FOS; proto-oncogene protein c-fos
   04728 Dopaminergic synapse
    K04379  FOS; proto-oncogene protein c-fos
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04379  FOS; proto-oncogene protein c-fos
  09159 Environmental adaptation
   04713 Circadian entrainment
    K04379  FOS; proto-oncogene protein c-fos
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04379  FOS; proto-oncogene protein c-fos
   05207 Chemical carcinogenesis - receptor activation
    K04379  FOS; proto-oncogene protein c-fos
   05208 Chemical carcinogenesis - reactive oxygen species
    K04379  FOS; proto-oncogene protein c-fos
   05231 Choline metabolism in cancer
    K04379  FOS; proto-oncogene protein c-fos
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04379  FOS; proto-oncogene protein c-fos
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04379  FOS; proto-oncogene protein c-fos
   05224 Breast cancer
    K04379  FOS; proto-oncogene protein c-fos
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04379  FOS; proto-oncogene protein c-fos
   05170 Human immunodeficiency virus 1 infection
    K04379  FOS; proto-oncogene protein c-fos
   05161 Hepatitis B
    K04379  FOS; proto-oncogene protein c-fos
   05171 Coronavirus disease - COVID-19
    K04379  FOS; proto-oncogene protein c-fos
   05162 Measles
    K04379  FOS; proto-oncogene protein c-fos
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04379  FOS; proto-oncogene protein c-fos
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04379  FOS; proto-oncogene protein c-fos
   05132 Salmonella infection
    K04379  FOS; proto-oncogene protein c-fos
   05135 Yersinia infection
    K04379  FOS; proto-oncogene protein c-fos
   05133 Pertussis
    K04379  FOS; proto-oncogene protein c-fos
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K04379  FOS; proto-oncogene protein c-fos
   05142 Chagas disease
    K04379  FOS; proto-oncogene protein c-fos
  09163 Immune disease
   05323 Rheumatoid arthritis
    K04379  FOS; proto-oncogene protein c-fos
  09165 Substance dependence
   05031 Amphetamine addiction
    K04379  FOS; proto-oncogene protein c-fos
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04379  FOS; proto-oncogene protein c-fos
   05418 Fluid shear stress and atherosclerosis
    K04379  FOS; proto-oncogene protein c-fos
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K04379  FOS; proto-oncogene protein c-fos
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K04379  FOS; proto-oncogene protein c-fos
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04379  FOS; proto-oncogene protein c-fos
   04131 Membrane trafficking
    K04379  FOS; proto-oncogene protein c-fos
Transcription factors [BR:ko03000]
Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, Fos
    K04379  FOS; proto-oncogene protein c-fos
Membrane trafficking [BR:ko04131]
Autophagy
  Chaperone mediated autophagy (CMA)
   Selective cargos
    K04379  FOS; proto-oncogene protein c-fos

Genes

HSA:

2353(FOS)

PTR:	453047(FOS)

PPS:	100987957(FOS)

GGO:	101127590(FOS)

PON:	100462290(FOS)

PPYG:

129012966(FOS)

NLE:	100585899(FOS)

HMH:	116456218(FOS)

SSYN:

129487641(FOS)

MCC:	702077(FOS)

MCF:	102143716(FOS)

MTHB:

126959543

MNI:	105495778(FOS)

CSAB:

103229352(FOS)

CATY:

105590868(FOS)

PANU:

101021141(FOS)

TGE:	112628560(FOS)

MLEU:

105540805(FOS)

RRO:	104677590(FOS)

RBB:	108534930(FOS)

TFN:	117069314(FOS)

PTEH:

111521118(FOS)

CANG:

105517139(FOS)

CJC:	100390054(FOS)

SBQ:	101046701(FOS)

CIMI:

108304440(FOS)

ANAN:

105707245(FOS)

CSYR:

103266527(FOS)

MMUR:

105858849(FOS)

LCAT:

123646534(FOS)

PCOQ:

105819831(FOS)

OGA:	100953435(FOS)

MMU:	14281(Fos)

MCAL:

110307063(Fos)

MPAH:

110324365(Fos)

RNO:	314322(Fos)

MCOC:

116080518(Fos)

ANU:	117697448(Fos)

MUN:	110546962(Fos)

CGE:	100689418(Fos)

MAUA:

101831721(Fos)

PROB:

127230991(Fos)

PLEU:

114698038(Fos)

MORG:

121452580(Fos)

MFOT:

126515189

AAMP:

119819161(Fos)

NGI:	103747342(Fos)

HGL:	101718383(Fos)

CPOC:

100713572(Fos)

CCAN:

109694000(Fos)

DORD:

105986734(Fos)

DSP:	122118881(Fos)

PLOP:

125363230(Fos)

NCAR:

124977967

MMMA:

107149351(Fos)

OCU:

100338345

OPI:	101526067(FOS)

TUP:	102491199(FOS)

GVR:	103605891(FOS)

CFA:	490792(FOS)

CLUD:

112657374(FOS)

VVP:	112927292(FOS)

VLG:	121493811(FOS)

NPO:	129496401(FOS)

AML:	100474867(FOS)

UMR:	103671011(FOS)

UAH:	113270317(FOS)

UAR:	123798968(FOS)

ELK:

111148602

LLV:

125105343

MPUF:

101685236(FOS)

MNP:	132000157(FOS)

MLK:	131836857(FOS)

NVS:	122893478(FOS)

ORO:	101366773(FOS)

EJU:	114207358(FOS)

ZCA:	113910278(FOS)

MLX:	118002212(FOS)

NSU:	110571456(FOS)

LWW:	102727855(FOS)

FCA:	493935(FOS)

PYU:	121032071(FOS)

PCOO:

112854981(FOS)

PBG:	122469346(FOS)

PVIV:

125168871(FOS)

LRUF:

124512631

PTG:	102952769(FOS)

PPAD:

109253856(FOS)

PUC:

125909334

AJU:

106974355

HHV:	120231952(FOS)

BTA:	280795(FOS)

BOM:	102275053(FOS)

BIU:	109565363(FOS)

BBUB:

102393791(FOS)

BBIS:

105000057(FOS)

CHX:	102171520(FOS)

OAS:	443218(FOS)

BTAX:

128053951(FOS)

ODA:	120852702(FOS)

CCAD:

122443873(FOS)

MBEZ:

129563123(FOS)

SSC:	100144486(FOS)

CFR:	102519397(FOS)

CBAI:

105075289(FOS)

CDK:	105086086(FOS)

VPC:	102533186(FOS)

BACU:

102997242(FOS)

BMUS:

118890999(FOS)

LVE:	103072956 103084433(FOS)

OOR:	101286650(FOS)

DLE:	111176238(FOS)

PCAD:

102982453(FOS)

PSIU:

116749519(FOS)

NASI:

112394907(FOS)

ECB:	100051632(FOS)

EPZ:	103548618(FOS)

EAI:	106827712(FOS)

MYB:	102246307(FOS)

MYD:	102764239(FOS)

MMYO:

118658230(FOS)

MLF:	102417433(FOS)

MDT:	132231259(FOS)

PKL:	118715156(FOS)

EFUS:

103283560(FOS)

MNA:	107533821(FOS)

DRO:	112311412(FOS)

SHON:

118976823(FOS)

AJM:	119049259(FOS)

PDIC:

114493153(FOS)

PHAS:

123808226(FOS)

MMF:	118618599(FOS)

PPAM:

129065732(FOS)

HAI:	109381526(FOS)

RFQ:	117024158(FOS)

PALE:

102891428(FOS)

PGIG:

120619517(FOS)

PVP:	105299213(FOS)

RAY:	107498912(FOS)

MJV:	108402534(FOS)

TOD:	119238328(FOS)

SARA:

101545059(FOS)

SETR:

126004042(FOS)

LAV:	100674799(FOS)

TMU:

101357016

ETF:	101656124(FOS)

DNM:	101431782(FOS)

MDO:	100018285(FOS)

GAS:	123237804(FOS)

SHR:	100924435(FOS)

AFZ:

127549484

PCW:	110208312(FOS)

TVP:	118829992(FOS)

OAA:	100075021(FOS)

GGA:	396512(FOS)

PCOC:

116229416(FOS)

MGP:

104916287

CJO:	107315165(FOS)

TPAI:

128086968(FOS)

LMUT:

125695245(FOS)

NMEL:

110400992(FOS)

APLA:

101801698(FOS)

ACYG:

106038794(FOS)

CATA:

118244473(FOS)

AFUL:

116489845(FOS)

TGU:	100222961(FOS)

LSR:	110477175(FOS)

SCAN:

103826521(FOS)

PMOA:

120500400(FOS)

OTC:	121333162(FOS)

PRUF:

121355973(FOS)

GFR:	102037526(FOS)

FAB:	101807505(FOS)

OMA:	130266853(FOS)

PHI:	102103181(FOS)

PMAJ:

107206453(FOS)

CCAE:

111945660(FOS)

CCW:	104685225(FOS)

ETL:	114056015(FOS)

ZLE:	135448975(FOS)

SVG:	106861661(FOS)

MMEA:

130578704(FOS)

HRT:	120754638(FOS)

SATI:

136363007(FOS)

FPG:	101921708(FOS)

SHAB:

115606485(FOS)

ACUN:

113480870(FOS)

TALA:

116959628(FOS)

ACHC:

115333806(FOS)

HLE:	104841955(FOS)

AGEN:

126049369

GCL:

127017203

DPUB:

104308225(FOS)

BRHI:

104501378(FOS)

CLV:	102098648(FOS)

CUCA:

128852401(FOS)

RTD:	128909213(FOS)

AAM:	106483057(FOS)

AROW:

112960526(FOS)

NPD:	112957980(FOS)

TGT:	104579149(FOS)

DNE:	112995446(FOS)

ASN:	102385076(FOS)

AMJ:	102562416(FOS)

CPOO:

109321539(FOS)

GGN:	109299320(FOS)

PSS:	102454531(FOS)

CMY:	102940899(FOS)

CCAY:

125638512(FOS)

DCC:	119857951(FOS)

CPIC:

101937366(FOS)

TST:	117876830(FOS)

CABI:

116837497(FOS)

MRV:	120405405(FOS)

ACS:	100556427(fos)

ASAO:

132764361(FOS)

PVT:	110079111(FOS)

SUND:

121918920(FOS)

PBI:	103049145(FOS)

PMUR:

107285955(FOS)

CTIG:

120311766(FOS)

TSR:	106545095(FOS)

PGUT:

117665838(FOS)

APRI:

131187775(FOS)

PTEX:

113443590(FOS)

NSS:	113410033(FOS)

VKO:	123026796(FOS)

PMUA:

114591829(FOS)

PRAF:

128408950(FOS)

ZVI:	118081801(FOS)

HCG:	128340943(FOS)

GJA:	107118325(FOS)

STOW:

125427132(FOS)

EMC:	129325320(FOS)

XLA:	108698676(fos.L) 447201(fos.S)

XTR:	548954(fos)

NPR:	108802481(FOS)

RTEM:

120920284(FOS)

BBUF:

120982209(FOS)

BGAR:

122923800(FOS)

MUO:	115477396(FOS)

GSH:	117364307(FOS)

DRE:	394198(fosab) 564403(si:ch211-153j24.3) 570238(fosaa)

SRX:	107719360 107719361 107723273 107724245(fos) 107742716 107742739

SANH:

107685356 107685357 107697117 107697196 107702235

SGH:	107550415 107550416 107554784(fos) 107593260 107593301

CCAR:

109062345 109074451 109080931 109080936 109103799 109103802

CAUA:

113060426 113097315 113097335 113116944 113120645 113120646

CGIB:

127938931 127938933 127975815 127984154 127984156(si:ch211-153j24.3) 128031400

PTET:

122324473(si:ch211-153j24.3) 122325196(fosab) 122361624(fosaa)

LROH:

127179306(fosaa) 127183261(fosab) 127183262(si:ch211-153j24.3)

OMC:	131523270(fosaa) 131526674(fosab) 131526675(si:ch211-153j24.3)

PPRM:

120460309(si:ch211-153j24.3) 120460310(fosab) 120462345(fosaa)

RKG:	130076711(fosaa) 130103126(fosab) 130103127(si:ch211-153j24.3)

MAMB:

125268283(fosaa) 125278491(fosab) 125278492(si:ch211-153j24.3)

CIDE:

127498056 127502293 127502294(si:ch211-153j24.3)

CERY:

137006970(fosaa) 137019192(fosab) 137019193(si:ch211-153j24.3)

MASI:

127409698 127409712 127410980 127415669 127415675 127455394

TROS:

130560085(fosaa) 130566284(si:ch211-153j24.3) 130566285(fosab)

TDW:	130434283(fosab) 130434596(si:ch211-153j24.3) 130436958(fosaa)

MANU:

129418294(fosaa) 129429927(fosab) 129429929(si:ch211-153j24.3)

IPU:	108255380(si:ch211-153j24.3) 108260991(fosab) 108269548(fosaa) 108278451(fosl1b)

IFU:	128612582(fosaa) 128616521(si:ch211-153j24.3) 128618142(fosab)

PHYP:

113525195 113525205 113538883 113541752

SMEO:

124390622(fosaa) 124401612(si:ch211-153j24.3) 124401616(fosab)

TFD:	113651743(si:ch211-153j24.3) 113651782(fosab) 113659351(fosaa)

TVC:	132852110(fosaa) 132854711(si:ch211-153j24.3) 132855121(fosab)

TRN:	134319796(fosab) 134320503(si:ch211-153j24.3) 134325251

AMEX:

103036705(fosaa) 103042954(si:ch211-153j24.3) 103043278(fosab) 107197750(fosl1b)

CMAO:

118816011(fosab) 118816012(si:ch211-153j24.3) 118823609(fosaa)

EEE:	113585922 113590125 113590136

CHAR:

105889778(si:ch211-153j24.3) 105889814(fosab) 105893125(fosaa)

TRU:	101067832 101068404 101078177

TFS:	130516370(fosab) 130516371(si:ch211-153j24.3) 130540365(fosaa)

TNG:	GSTEN00030333G001

LCO:	104922420 104922421 109141650(fos)

NCC:	104943718 104951063 104951064

TBEN:

117471609(fosaa) 117493227(si:ch211-153j24.3) 117493507(fosab)

CGOB:

115003606 115003607 115027399

PGEO:

117440361(si:ch211-153j24.3) 117440362(fosab) 117468017

GACU:

117533795(fosab) 117533803 117549989(fosaa)

EMAC:

134876857 134876858(fosab) 134881848(fosaa)

ELY:	117270660 117270661(fosab)

EFO:	125896733 125896734(fosab)

PLEP:

121953330(fosaa) 121955706 121955772

SLUC:

116035578(fosaa) 116066178 116066292(fosab)

ECRA:

117936115(fosaa) 117961110 117961111

ESP:	116670054 116706488 116706489

PFLV:

114546536 114573364 114573365

GAT:	120808499 120808500 120832806(fosaa)

PPUG:

119195001 119195002 119227788(fosaa)

AFB:	129103766(fosaa) 129107117 129107352

CLUM:

117725194(fosaa) 117727586 117727588(fosab)

PSWI:

130201320(fosaa) 130202564(fosab) 130202820

MSAM:

119908415 119909126 119909776(fosaa)

SCHU:

122862302(fosaa) 122862755(fosab) 122862756(si:ch211-153j24.3)

CUD:	121520963(fosab) 121521743(si:ch211-153j24.3) 121526444(fosaa)

ALAT:

119004342(fosaa) 119012066 119012067

MZE:	101467033 101487312 101487601

ONL:	100709203 100709467 100711598

OAU:	116313320(fosaa) 116314098 116314100(fosab)

OLA:	100820712(c-fos) 101165186 101167759

OML:	112150122(fosaa) 112158236(fosab) 112158237

CSAI:

133418335(fosab) 133462543(fosaa) 133464900

XMA:	102222672 102223022 102224057

XCO:	114133978 114158175 114158176

XHE:	116709123 116734396 116734702

PRET:

103457598 103457600(c-fos) 103459044

PFOR:

103136169 103138628 103138629

PLAI:

106938759 106938764 106949832

PMEI:

106920010 106920011 106923538

GAF:	122825457 122825706 122845838(fosaa)

PPRL:

129351171 129351172 129365183(fosaa)

CVG:	107083128 107083139 107092405

CTUL:

119785058(fosab) 119785064(si:ch211-153j24.3) 119787546(fosaa)

GMU:	124881577 124881628 124884856(fosaa)

NFU:	107377523 107377524 107392399

KMR:	108233178(fosaa) 108242438(fosab) 108242442(si:ch211-153j24.3)

ALIM:

106516915 106516916 106520572

NWH:	119418187(fosab) 119418189 119427921(fosaa)

AOCE:

111565479 111574573 111583367 111583368

MCEP:

124999159 124999160 125023193(fosaa)

CSEM:

103380804 103380805 103399847

POV:	109627836 109636028 109648142

SSEN:

122783001(fosaa) 122784299 122784300

HHIP:

117756645(fosaa) 117758243 117758245(fosab)

HSP:	118099879 118099880 118116885(fosaa)

PPLT:

128451090(fosaa) 128460085 128460086

SMAU:

118286690(fosaa) 118290484(si:ch211-153j24.3) 118290485(fosab)

LCF:	108892487(fosaa) 108895610(si:ch211-153j24.3) 108895611(fosab)

SDU:	111216358 111225857 111239160

SLAL:

111653021 111653033 111663204

XGL:	120789178 120789444(fosab) 120795587(fosaa)

HCQ:	109507751 109524837 109524839

SSCV:

125981396 125990318 125990320(si:ch211-153j24.3)

SBIA:

133513222

PEE:	133412738(fosaa) 133417283(fosab) 133417284

PTAO:

133468338 133468339(fosab) 133487442(fosaa)

BPEC:

110155664 110156391 110157774

MALB:

109955143 109969997 109970022

BSPL:

114849092(fosaa) 114849947 114849948

SJO:	128375379(fosaa)

SASA:

106571028 106571032 106591288 106608293 106608294 106611096

STRU:

115147345 115151505 115162327 115172608 115175159 115175160

OTW:	112233100 112235301 112235302 112236219 112236220(fosab) 112256701

OMY:	110497916 110505549(fosaa) 110521119 110522641 110529274 110529275

OGO:	123991483 123991528 123995451 123995453 124001991 124046464

ONE:	115116789 115116793 115118998 115118999 115138514 115146645

OKI:	109879520 109879526 109880621 109880626 109893938 109903187

OKE:	118362495 118369242(fosaa) 118376443(fosab) 118376444 118382832 118382833

SALP:

111963282(fos) 111968729 112070669 112070673 112072979 112072980

SNH:	120019205(fosab) 120019412 120023674 120024158 120024271 120060304

CCLU:

121538805 121544365(fosaa) 121552600 121556166 121556172

ELS:	105005940 105005941 105026425

SFM:	108930699 108930709 108936678 108936694

PKI:	111844398 111844443 111852373 111852518

AANG:

118217556 118217618 118229166 118229370

LOC:	102690879(fos) 102691085

PSPA:

121307641 121307658 121324393 121324394

ARUT:

117409032 117417438 117422027 117422116

PSEX:

120518579(fosab) 120518863

LCM:	102361375(FOS)

CMK:	103189966(fos)

RTP:

CPLA:

HOC:

LERI:

PMRN:

116939548 116939549 116943296 116947250 116947715 116948458 116953962

LRJ:	133341443 133342295 133347174 133347175 133352682 133356181

BBEL:

109471128

CIN:	778607(fos)

SCLV:

TPRE:

AGIF:

CSET:

AGB:

APLN:

PPYR:

BANY:

MCIX:

OFU:

DMK:	116926194 116935452

PJA:	122246248 122255211

PCHN:

125041124 125046386

PCLA:

123745849 123752751 123753047

CQD:

128697682

PTRU:

123505463 123509943 123518199

HAZT:

PPOI:

DSV:

RSAN:

RMP:

SDM:	118196290 118204592

NAI:	NECAME_10724

BGT:

106063678

GAE:	121371342 121372432 121379175

HRF:	124121581 124148487

HRJ:

124268854

CRG:	105337016 105349020

OED:

125649072

PMAX:

117324185 117324186 117324250 117324416

MMER:

OSN:

ATEN:

Reference

PMID:19167516

Authors

Vesely PW, Staber PB, Hoefler G, Kenner L

Title

Translational regulation mechanisms of AP-1 proteins.

Journal

Mutat Res 682:7-12 (2009)
DOI:10.1016/j.mrrev.2009.01.001

Reference

PMID:6574479

Authors

van Straaten F, Muller R, Curran T, Van Beveren C, Verma IM

Title

Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein.

Journal

Proc Natl Acad Sci U S A 80:3183-7 (1983)
DOI:10.1073/pnas.80.11.3183

Sequence

[hsa:2353]

Reference

PMID:17160021

Authors

Portal MM, Ferrero GO, Caputto BL

Title

N-Terminal c-Fos tyrosine phosphorylation regulates c-Fos/ER association and c-Fos-dependent phospholipid synthesis activation.

Journal

Oncogene 26:3551-8 (2007)
DOI:10.1038/sj.onc.1210137

Sequence

[hsa:2353]

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