KEGG ORTHOLOGY: K04450

ORTHOLOGY: K04450

Entry

K04450                      KO

Symbol

ATF2, CREBP1

Name

cyclic AMP-dependent transcription factor ATF-2

Pathway

map04010

MAPK signaling pathway

map04013

MAPK signaling pathway - fly

map04022

cGMP-PKG signaling pathway

map04151

PI3K-Akt signaling pathway

map04211

Longevity regulating pathway

map04261

Adrenergic signaling in cardiomyocytes

map04624

Toll and Imd signaling pathway

map04668

TNF signaling pathway

map04714

Thermogenesis

map04728

Dopaminergic synapse

map04911

Insulin secretion

map04915

Estrogen signaling pathway

map04918

Thyroid hormone synthesis

map04922

Glucagon signaling pathway

map04925

Aldosterone synthesis and secretion

map04926

Relaxin signaling pathway

map04927

Cortisol synthesis and secretion

map04928

Parathyroid hormone synthesis, secretion and action

map04934

Cushing syndrome

map04935

Growth hormone synthesis, secretion and action

map05020

Prion disease

map05030

Cocaine addiction

map05031

Amphetamine addiction

map05034

Alcoholism

map05161

Hepatitis B

map05163

Human cytomegalovirus infection

map05166

Human T-cell leukemia virus 1 infection

map05203

Viral carcinogenesis

map05207

Chemical carcinogenesis - receptor activation

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04013 MAPK signaling pathway - fly
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04668 TNF signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04022 cGMP-PKG signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04151 PI3K-Akt signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
09150 Organismal Systems
  09151 Immune system
   04624 Toll and Imd signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09152 Endocrine system
   04911 Insulin secretion
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04922 Glucagon signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04915 Estrogen signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04926 Relaxin signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04935 Growth hormone synthesis, secretion and action
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04918 Thyroid hormone synthesis
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04928 Parathyroid hormone synthesis, secretion and action
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04925 Aldosterone synthesis and secretion
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04927 Cortisol synthesis and secretion
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09156 Nervous system
   04728 Dopaminergic synapse
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09149 Aging
   04211 Longevity regulating pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09159 Environmental adaptation
   04714 Thermogenesis
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   05203 Viral carcinogenesis
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   05161 Hepatitis B
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   05163 Human cytomegalovirus infection
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09164 Neurodegenerative disease
   05020 Prion disease
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09165 Substance dependence
   05030 Cocaine addiction
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   05031 Amphetamine addiction
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   05034 Alcoholism
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
Transcription factors [BR:ko03000]
Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, CRE-BP/ATF
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2

Other DBs

GO:

0035497

Genes

HSA:	1386(ATF2)

PTR:	101059354(ATF2)

PPS:	100985706(ATF2)

GGO:	101135003(ATF2)

PON:	100450554(ATF2)

PPYG:

129031088(ATF2)

NLE:	100582751(ATF2)

HMH:	116810639(ATF2)

SSYN:

129488074(ATF2)

MCC:	699072(ATF2)

MCF:	101925838(ATF2)

MTHB:

126932678

MNI:	105483203(ATF2)

CSAB:

103217363(ATF2)

CATY:

105579833(ATF2)

PANU:

101011350(ATF2)

TGE:	112636593(ATF2)

MLEU:

105548041(ATF2)

RRO:	104672399(ATF2)

RBB:	108527163(ATF2)

TFN:	117094833(ATF2)

PTEH:

111542753(ATF2)

CANG:

105513158(ATF2)

CJC:	100414156(ATF2)

SBQ:	101035834(ATF2)

CIMI:

108311016(ATF2)

ANAN:

105730599(ATF2)

CSYR:

103264952(ATF2)

MMUR:

105865052(ATF2)

LCAT:

123643408(ATF2)

PCOQ:

105815570(ATF2)

OGA:	100966891(ATF2)

MMU:	11909(Atf2)

MCAL:

110286367(Atf2)

MPAH:

110317821(Atf2)

RNO:	81647(Atf2)

MCOC:

116091666(Atf2)

ANU:	117703314(Atf2)

MUN:	110556579(Atf2)

CGE:	100754663(Atf2)

MAUA:

101836768(Atf2)

PROB:

127222404(Atf2)

PLEU:

114700827(Atf2)

MORG:

121439096 121439299

MFOT:

126487367

AAMP:

119819075(Atf2)

NGI:	103751761(Atf2)

HGL:	101717365(Atf2)

CPOC:

100726889(Atf2)

CCAN:

109689841(Atf2)

DORD:

105995552(Atf2)

DSP:	122120051(Atf2)

PLOP:

125350538(Atf2)

NCAR:

124979831

MMMA:

107136939(Atf2)

OCU:

100355367

OPI:	101526116(ATF2)

TUP:	102473406(ATF2)

GVR:	103605275(ATF2)

CFA:	478806(ATF2)

CLUD:

112668134(ATF2)

VVP:	112916383(ATF2)

VLG:	121501564(ATF2)

NPO:	129498595(ATF2)

AML:	100474135(ATF2)

UMR:	103659593(ATF2)

UAH:	113250749(ATF2)

UAR:	123794100(ATF2)

ELK:

111142901

LLV:

125095761

MPUF:

101690544(ATF2)

MNP:	132013851(ATF2)

MLK:	131827068(ATF2)

NVS:	122902614(ATF2)

ORO:	101374034(ATF2)

EJU:	114224124(ATF2)

ZCA:	113919173(ATF2)

MLX:	118012308(ATF2)

NSU:	110592390(ATF2)

LWW:	102746508(ATF2)

FCA:	101090884(ATF2)

PYU:	121030728(ATF2)

PCOO:

112848765(ATF2)

PBG:	122481480(ATF2)

PVIV:

125172214(ATF2)

LRUF:

124514138

PTG:	102954603(ATF2)

PPAD:

109273371(ATF2)

PUC:

125911819

AJU:

106988085

HHV:	120243894(ATF2)

BTA:	509827(ATF2)

BOM:	102283891(ATF2)

BIU:	109566270(ATF2)

BBUB:

102410577(ATF2)

BBIS:

105002941(ATF2)

CHX:	102180634(ATF2)

OAS:	101108548(ATF2)

BTAX:

128065610(ATF2)

ODA:	120854293(ATF2)

CCAD:

122453548(ATF2)

MBEZ:

129537505(ATF2)

SSC:	100513441(ATF2)

CFR:	102512476(ATF2)

CBAI:

105073454(ATF2)

CDK:	105097571(ATF2)

VPC:	102542128(ATF2)

BACU:

102999133(ATF2)

BMUS:

118898040(ATF2)

LVE:	103089070(ATF2)

OOR:	101276923(ATF2)

DLE:	111172890(ATF2)

PCAD:

102974369(ATF2) 102986837

PSIU:

116756632(ATF2)

NASI:

112391502(ATF2)

ECB:	100053304(ATF2)

EPZ:	103553756(ATF2)

EAI:	106837905(ATF2)

MYB:	102241887(ATF2)

MYD:	102761389(ATF2)

MMYO:

118661230(ATF2)

MLF:	102418405(ATF2)

MDT:	132238509(ATF2)

PKL:	118709956(ATF2)

EFUS:

103283488(ATF2)

MNA:	107532468(ATF2)

DRO:	112305718(ATF2)

SHON:

118985682(ATF2)

AJM:	119057201(ATF2)

PDIC:

114495679(ATF2)

PHAS:

123808666(ATF2)

MMF:	118625175(ATF2)

PPAM:

129061773(ATF2)

HAI:	109388738(ATF2)

RFQ:	117025773(ATF2)

PALE:

102889014(ATF2)

PGIG:

120597156(ATF2)

PVP:	105290195(ATF2)

RAY:	107504977(ATF2)

MJV:	108396432(ATF2)

TOD:	119255950(ATF2)

SARA:

101539734(ATF2)

SETR:

126006901 126009077(ATF2)

LAV:	100657989(ATF2)

TMU:

101359884

ETF:	101656771(ATF2)

DNM:	101414225(ATF2)

MDO:	100025939(ATF2)

GAS:	123242200(ATF2)

SHR:	100914193(ATF2)

AFZ:

127554549

PCW:	110211588(ATF2)

TVP:	118837606(ATF2)

OAA:	100077942(ATF2)

GGA:	395727(ATF2)

PCOC:

116232833(ATF2)

MGP:	100549420(ATF2)

CJO:	107316660(ATF2)

NMEL:

110399453(ATF2)

APLA:

101800932(ATF2)

ACYG:

106030015(ATF2)

CATA:

118258511(ATF2)

AFUL:

116490508(ATF2)

TGU:	100226584(ATF2)

LSR:	110482896(ATF2)

SCAN:

103814449(ATF2)

PMOA:

120500700(ATF2)

OTC:	121335296(ATF2)

PRUF:

121356463(ATF2)

GFR:	102034606(ATF2)

FAB:	101812575(ATF2)

OMA:	130255810(ATF2)

PHI:	102105113(ATF2)

PMAJ:

107207532(ATF2)

CCAE:

111932059(ATF2)

CCW:	104693853(ATF2)

CBRC:

103616554(ATF2)

ETL:	114054885(ATF2)

ZAB:	102072645(ATF2)

ZLE:	135450022(ATF2)

ACHL:

103808275(ATF2)

SVG:	106855478(ATF2)

MMEA:

130572185(ATF2)

HRT:	120754937(ATF2)

SATI:

136363487(ATF2)

FPG:	101912040(ATF2)

FCH:	102052727(ATF2)

NNT:	104400645(ATF2)

SHAB:

115609022(ATF2)

ACUN:

113482190(ATF2)

TALA:

104364997(ATF2)

ACHC:

115342678(ATF2)

HALD:

104325322

HLE:	104831037(ATF2)

AGEN:

126051349

GCL:

127018309

CSTI:

104551232(ATF2)

LDI:	104348460(ATF2)

MNB:	103769937(ATF2)

DPUB:

104305746(ATF2)

AVIT:

104271266(ATF2)

BRHI:

104488444(ATF2)

EGZ:	104128067(ATF2)

NNI:	104010014(ATF2)

PCRI:

104027613(ATF2)

PCAO:

104048724(ATF2)

PADL:

103924112(ATF2)

AFOR:

103898343(ATF2)

FGA:	104070884(ATF2)

GSTE:

104252248

CLV:	102084432(ATF2)

MUI:	104534912(ATF2)

PGUU:

104459355(ATF2)

EHS:	104504246(ATF2)

CMAC:

104476630(ATF2)

CUCA:

104054576(ATF2)

TEO:	104372757(ATF2)

BREG:

104641601(ATF2)

OHA:	104328961(ATF2)

ACAR:

104521482(ATF2)

CPEA:

104387402(ATF2)

CVF:	104294868(ATF2)

RTD:	128912270(ATF2)

AAM:	106499205(ATF2)

AROW:

112970626(ATF2)

NPD:	112958230(ATF2)

TGT:	104565130(ATF2)

DNE:	112978957(ATF2)

SCAM:

104148543(ATF2)

ASN:	102387336(ATF2)

AMJ:	102572172(ATF2)

CPOO:

109322848(ATF2)

GGN:	109301712(ATF2)

PSS:	102460331(ATF2)

CMY:	102939131(ATF2)

CCAY:

125645235(ATF2)

DCC:	119863210(ATF2)

CPIC:

101945668(ATF2)

TST:	117884769(ATF2)

CABI:

116827201(ATF2)

MRV:	120375150(ATF2)

ACS:	100557710(atf2)

ASAO:

132777089(ATF2)

PVT:	110085213(ATF2)

SUND:

121932133(ATF2)

PBI:	103053462(ATF2)

PMUR:

107301365(ATF2)

CTIG:

120306308(ATF2)

TSR:	106548735(ATF2)

PGUT:

117671729(ATF2)

APRI:

131201858(ATF2)

PTEX:

113434057(ATF2)

NSS:	113418677(ATF2)

VKO:	123021813(ATF2)

PMUA:

114606668(ATF2) 114606722

PRAF:

128424426(ATF2)

ZVI:	118094461(ATF2)

HCG:	128334488(ATF2)

GJA:	107123397(ATF2)

STOW:

125427340(ATF2)

EMC:	129324375(ATF2)

XLA:	108701386(atf2.L) 108703012

XTR:	100485532(atf2)

NPR:	108800395(ATF2)

RTEM:

120943988(ATF2)

BBUF:

121007592(ATF2)

BGAR:

122944878(ATF2)

MUO:	115473832(ATF2)

GSH:	117360797(ATF2)

DRE:	100006516(atf2)

SRX:	107739459 107742976

SANH:

107657392 107671311

SGH:

107600703

CCAR:

109050033 109050035

CAUA:

113053545 113109105(atf2)

CGIB:

127965330 128019591

PTET:

122351902(atf2)

LROH:

127171249(atf2)

OMC:	131546731(atf2)

PPRM:

120459863(atf2)

MAMB:

125269821(atf2)

CIDE:

127519043

CERY:

137035708(atf2)

MASI:

127447418 127448348

TROS:

130555365(atf2)

TDW:	130427747(atf2)

MANU:

129451730(atf2)

IPU:

108266715

IFU:	128608891(atf2)

PHYP:

113525280(atf2)

SMEO:

124382881(atf2)

TFD:	113654398(atf2)

TVC:	132850230(atf2)

TRN:	134324755(atf2)

AMEX:

103028069(atf2)

CMAO:

118805699(atf2)

EEE:	113582331(atf2)

CHAR:

105908058(atf2)

TRU:	101063333(atf2)

TFS:	130524512(atf2)

LCO:	104924439(atf2)

NCC:	104965544(atf2)

TBEN:

117481257(atf2)

CGOB:

115026508(atf2)

PGEO:

117466171(atf2)

GACU:

117544446(atf2)

EMAC:

134867186(atf2)

ELY:	117251515(atf2)

EFO:	125899825(atf2)

PLEP:

121949234(atf2)

SLUC:

116048273(atf2)

ECRA:

117952621(atf2)

ESP:	116697624(atf2)

PFLV:

114564663(atf2)

GAT:	120833901(atf2)

PPUG:

119229099(atf2)

AFB:	129104615(atf2)

CLUM:

117750136(atf2)

PSWI:

130201859(atf2)

MSAM:

119904115(atf2)

SCHU:

122885712(atf2)

CUD:	121523045(atf2)

ALAT:

119026332(atf2)

MZE:	101463949(atf2)

ONL:	100699389(atf2)

OAU:	116322969(atf2)

OLA:	101161843(atf2)

OML:	112155414(atf2)

CSAI:

133445927(atf2)

XMA:	102234028(atf2)

XCO:	114148083(atf2)

XHE:	116723009(atf2)

PRET:

103458305(atf2)

PFOR:

103134309(atf2)

PLAI:

106957443(atf2)

PMEI:

106924454(atf2)

GAF:	122840186(atf2)

PPRL:

129361150(atf2)

CVG:	107085739(atf2)

CTUL:

119797535(atf2)

GMU:	124871553(atf2)

NFU:	107390001(atf2)

KMR:	108239783(atf2)

ALIM:

106512883(atf2)

NWH:	119419612(atf2)

AOCE:

111577835(atf2)

MCEP:

125017444(atf2)

CSEM:

103391862 107988055(atf2)

POV:	109631016(atf2)

SSEN:

122759712(atf2)

HHIP:

117754585(atf2)

HSP:	118120014(atf2)

PPLT:

128456054(atf2)

SMAU:

118320636(atf2)

LCF:

108882968

SDU:	111218870(atf2)

SLAL:

111654625(atf2)

XGL:	120801815(atf2)

HCQ:	109507870(atf2)

SSCV:

125973384

SBIA:

133512284(atf2)

PEE:	133410969(atf2)

PTAO:

133486594(atf2)

BPEC:

110166549(atf2)

MALB:

109958112(atf2)

BSPL:

114847325(atf2)

SASA:

106582491 106586246(atf2)

STRU:

115160774

OTW:	112236821(atf2)

OMY:	110501941 110520124(atf2)

OGO:	124043875(atf2)

ONE:	115109253(atf2)

OKI:	109866805(atf2)

OKE:	118367052(atf2)

SALP:

111959522 111975332(atf2)

SNH:	120058257(atf2)

CCLU:

121536772(atf2) 121555148

ELS:	105016218(atf2)

SFM:	108920372(atf2) 108928057

PKI:	111838634(atf2)

AANG:

118214264 118224160(atf2)

LOC:	102687984(atf2)

PSPA:

121322207 121323264

ARUT:

117409383 117426833(atf2)

PSEX:

120531866(atf2)

LCM:	102366239(ATF2) 106703183

CMK:	103176469(atf2)

RTP:	109929477(atf2)

CPLA:

122551542(atf2)

HOC:	132817478(atf2)

LERI:

129698729(atf2)

PMRN:

116941550 116943795 116954785

LRJ:	133344256 133344279 133356885 133358345

BFO:

BBEL:

SPU:

APLC:

ARUN:

AJC:

DME:	Dmel_CG44246(Atf-2)

DER:

6548433

DSE:

6618893

DSI:	Dsimw501_GD11905(Dsim_GD11905)

DYA:	Dyak_GE14449

DAN:

DSR:

DPO:

DPE:

DMN:	108160147 117193413

DWI:

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

AOQ:

TDA:	119664084 119672680 119674867 119685334 119685826

MDE:

SCAC:

LSQ:

ECOE:

ACOZ:

AARA:

ASTE:

AMOU:

AALI:

AAG:

ASUA:

CQU:	CpipJ_CPIJ004851

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:	115239013 115244371

LHU:	105677106(Atf-2)

PGC:

109858507

OBO:	105285441 113562127

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

ATD:

AGB:

LDC:

DVV:

NVL:

PPYR:

BMOR:

BMAN:

MSEX:

DPL:	KGM_203627

BANY:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

AAGE:

HAW:	110369623(Atf-2)

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

LGLY:

ACOO:

BTAB:

DCI:

CLEC:

NLU:

HVI:

MQU:	128998288 128998328

PHU:	Phum_PHUM600910

FOC:

TPAL:

ZNE:

CSEC:

BROR:

FCD:

DPX:	DAPPUDRAFT_324326

DMK:

PVM:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

EAF:

DSV:

RSAN:

RMP:

VDE:	111245204 111254791

VJA:

CSCU:

CVS:

PTEP:

ABRU:

UDV:	129223224 129223225

SDM:

LPOL:

PVUL:

PCAN:

BGT:

GAE:

HRF:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MMER:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_080420

OVI:	T265_08172

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_60644

AQU:

100632529

VCN:	VOLCADRAFT_121646

APRO:

F751_3120

PPEI:

PpBr36_09264

BZE:	COCCADRAFT_107531

BSC:	COCSADRAFT_38397

BOR:	COCMIDRAFT_104283

» show all

Reference

PMID:2529117

Authors

Maekawa T, Sakura H, Kanei-Ishii C, Sudo T, Yoshimura T, Fujisawa J, Yoshida M, Ishii S

Title

Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain.

Journal

EMBO J 8:2023-8 (1989)
DOI:10.1002/j.1460-2075.1989.tb03610.x

Sequence

[hsa:1386]

Reference

PMID:10821277

Authors

Kawasaki H, Schiltz L, Chiu R, Itakura K, Taira K, Nakatani Y, Yokoyama KK

Title

ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation.

Journal

Nature 405:195-200 (2000)
DOI:10.1038/35012097

Sequence

[hsa:1386]

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   KEGG BRITE (2)   
   GO (1)   
Pathway (58)   
   KEGG PATHWAY (58)   
Gene (1324)   
   KEGG GENES (626)   
   KEGG MGENES (227)   
   RefGene (459)   
   OC (12)   
Literature (2)   
   PubMed (2)   
All databases (1387)   

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