KEGG ORTHOLOGY: K04455

ORTHOLOGY: K04455

Entry

K04455                      KO

Symbol

HSPB1

Name

heat shock protein beta-1

Pathway

map04010

MAPK signaling pathway

map04370

VEGF signaling pathway

map05146

Amoebiasis

Disease

H00264

Charcot-Marie-Tooth disease

H00856

Distal hereditary motor neuropathies

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04455  HSPB1; heat shock protein beta-1
   04370 VEGF signaling pathway
    K04455  HSPB1; heat shock protein beta-1
09160 Human Diseases
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K04455  HSPB1; heat shock protein beta-1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03041 Spliceosome
    K04455  HSPB1; heat shock protein beta-1
   03110 Chaperones and folding catalysts
    K04455  HSPB1; heat shock protein beta-1
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04455  HSPB1; heat shock protein beta-1
Spliceosome [BR:ko03041]
Complex B
  U4/U6.U5 tri-snRNP components
   U4/U6.U5 tri-snRNP related factors
    K04455  HSPB1; heat shock protein beta-1
Complex C
  U4/U6.U5 tri-snRNP components
   U4/U6.U5 tri-SnRNP related factors
    K04455  HSPB1; heat shock protein beta-1
Chaperones and folding catalysts [BR:ko03110]
Heat shock proteins
  HSP20
   K04455  HSPB1; heat shock protein beta-1
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K04455  HSPB1; heat shock protein beta-1
  Exosomal proteins of breast cancer cells
   K04455  HSPB1; heat shock protein beta-1
  Exosomal proteins of bladder cancer cells
   K04455  HSPB1; heat shock protein beta-1

Genes

HSA:	3315(HSPB1)

PTR:	463488(HSPB1)

PPS:	100989754(HSPB1)

GGO:	101139318(HSPB1)

PON:	100449501(HSPB1)

PPYG:

129041190(HSPB1)

NLE:	100606388 115831000(HSPB1)

HMH:	116811162(HSPB1)

SSYN:

129462953 129489728(HSPB1)

MCC:	715615(HSPB1)

MCF:	101865323(HSPB1)

MTHB:

126950413

MNI:	105492764(HSPB1)

CSAB:

103246661

CATY:

105593379(HSPB1)

PANU:

101001143(HSPB1)

TGE:	112620377(HSPB1)

RRO:	104681213(HSPB1)

RBB:	108518926(HSPB1)

TFN:	117072460(HSPB1)

PTEH:

111547067(HSPB1)

CJC:	100408221(HSPB1)

SBQ:	101031388(HSPB1)

CIMI:

108307927(HSPB1)

ANAN:

105707461 105714890(HSPB1)

CSYR:

103271573(HSPB1)

MMUR:

105868391(HSPB1)

LCAT:

123632591(HSPB1)

PCOQ:

105807026(HSPB1)

OGA:	100940733(HSPB1)

MMU:	15507(Hspb1)

MPAH:

110312972(Hspb1)

RNO:	24471(Hspb1)

MCOC:

116070952(Hspb1)

ANU:	117697658(Hspb1)

MUN:	110555867(Hspb1)

CGE:	100763481(Hspb1)

MAUA:

101844946(Hspb1)

PROB:

127236964(Hspb1)

PLEU:

114710308(Hspb1)

MORG:

121446265(Hspb1)

MFOT:

126492740

AAMP:

119825268(Hspb1)

NGI:	103733473(Hspb1)

HGL:	101716096(Hspb1)

CPOC:

100724197(Hspb1)

CCAN:

109681577(Hspb1)

DORD:

105997357(Hspb1)

DSP:	122113754(Hspb1)

PLOP:

125368088(Hspb1)

NCAR:

124970339

MMMA:

107146591(Hspb1)

OCU:	100354523 127488490

OPI:	101531012(HSPB1)

TUP:	102469463(HSPB1)

GVR:	103610401(HSPB1)

CFA:	403979(HSPB1)

CLUD:

112646174(HSPB1)

VVP:	112935776(HSPB1)

VLG:	121488201(HSPB1)

NPO:	129519118(HSPB1)

AML:	100464257(HSPB1)

UMR:	103670211(HSPB1)

UAH:	113267813(HSPB1)

UAR:	123784760(HSPB1)

ELK:

111145764

LLV:

125091098

MPUF:

101673707(HSPB1)

MNP:	132027155(HSPB1)

MLK:	131819699(HSPB1)

NVS:	122895305(HSPB1)

ORO:	101364789(HSPB1)

EJU:	114214416(HSPB1)

ZCA:	113932425(HSPB1)

MLX:	117999468(HSPB1)

NSU:	110589935(HSPB1)

LWW:	102750441(HSPB1)

FCA:	101084411(HSPB1)

PYU:	121017703(HSPB1)

PCOO:

112860084(HSPB1)

PBG:	122471344(HSPB1)

PVIV:

125154336(HSPB1)

LRUF:

124519231

PPAD:

109250571(HSPB1)

PUC:

125928521

AJU:

106980703

HHV:	120239263(HSPB1)

BTA:	516099(HSPB1)

BOM:	102271616(HSPB1)

BIU:	109578689(HSPB1)

BBUB:

102406703(HSPB1)

BBIS:

104998925(HSPB1)

CHX:	108633906(HSPB1)

OAS:	101115754(HSPB1)

BTAX:

128064766(HSPB1)

ODA:	120878843(HSPB1)

CCAD:

122433179(HSPB1)

MBEZ:

129545641(HSPB1)

SSC:	493184(HSPB1)

CFR:	102521732(HSPB1)

CBAI:

105082705(HSPB1)

CDK:	105089647(HSPB1)

VPC:	102526513(HSPB1)

BACU:

103010521(HSPB1)

BMUS:

118881936(HSPB1)

LVE:	103084559(HSPB1)

OOR:	101288052(HSPB1) 101288848

DLE:	111182019(HSPB1)

PCAD:

102984443(HSPB1)

PSIU:

116741004(HSPB1)

NASI:

112399969(HSPB1)

ECB:	100059763(HSPB1)

EPZ:	103560974(HSPB1)

EAI:	106839277(HSPB1)

MYB:	102244977(HSPB1)

MYD:	102752420(HSPB1) 102773748

MMYO:

118656141(HSPB1)

MLF:	102438706(HSPB1)

MDT:	132233214(HSPB1)

PKL:	118703305(HSPB1)

EFUS:

103286023(HSPB1)

MNA:	107526554(HSPB1)

DRO:	112314926(HSPB1)

SHON:

118992820(HSPB1)

AJM:	119044696(HSPB1)

PDIC:

114498858(HSPB1)

PHAS:

123806417(HSPB1)

MMF:	118642477(HSPB1)

PPAM:

129083795(HSPB1)

HAI:	109384987(HSPB1)

RFQ:	117024493(HSPB1)

PALE:

102895169(HSPB1)

PGIG:

120591585(HSPB1)

PVP:	105299697(HSPB1)

RAY:	107511798(HSPB1)

MJV:	108393302(HSPB1)

TOD:	119240148(HSPB1)

SARA:

101545629(HSPB1)

SETR:

126029588(HSPB1)

TMU:

101345916

ETF:	101655758(HSPB1)

DNM:	101422899(HSPB1)

MDO:	100029144(HSPB1)

GAS:	123247525(HSPB1)

SHR:	100932713(HSPB1)

AFZ:

127558653

PCW:	110221279(HSPB1)

TVP:	118856058(HSPB1)

OAA:	114817692(HSPB1)

GGA:	396227(HSPB1)

PCOC:

116228151(HSPB1)

MGP:	100544357(HSPB1)

CJO:	107322717(HSPB1)

TPAI:

128083633(HSPB1)

LMUT:

125702907(HSPB1)

NMEL:

110407708(HSPB1)

APLA:

113845585(HSPB1)

ACYG:

106041405(HSPB1)

CATA:

118254133(HSPB1)

AFUL:

116497214(HSPB1)

TGU:	100225266(HSPB1)

LSR:	110472842(HSPB1)

SCAN:

103820075(HSPB1)

PMOA:

120507844(HSPB1)

OTC:	121345824(HSPB1)

PRUF:

121361726(HSPB1)

GFR:	102035750(HSPB1)

FAB:	101805999(HSPB1)

OMA:	130261049(HSPB1)

PHI:	102108887(HSPB1)

PMAJ:

107212733(HSPB1)

CCAE:

111937703(HSPB1)

CCW:	120411033(HSPB1)

ETL:	114056681(HSPB1)

ZLE:	135455799(HSPB1)

SVG:	106853292(HSPB1)

MMEA:

130577764(HSPB1)

HRT:	120761323(HSPB1)

SATI:

136370032(HSPB1)

FPG:	101922554(HSPB1)

FCH:	102057239(HSPB1)

SHAB:

115602066(HSPB1)

TALA:

116965223(HSPB1)

ACHC:

115346822(HSPB1)

HLE:	104835520(HSPB1)

AGEN:

126039334

GCL:

127024384

EGZ:	104131906(HSPB1)

CLV:	102096240(HSPB1)

CUCA:

104058674(HSPB1)

CPEA:

104396208(HSPB1)

RTD:	128912742(HSPB1)

AAM:	106497316(HSPB1)

AROW:

112965006(HSPB1)

NPD:	112956720(HSPB1)

TGT:	104574389(HSPB1)

DNE:	112987365(HSPB1)

ASN:	102380680(HSPB1)

AMJ:	102575596(HSPB1)

CPOO:

109317000(HSPB1)

GGN:	109293507(HSPB1)

PSS:	102452619(HSPB1)

CMY:	102944991(HSPB1)

CCAY:

125624119(HSPB1)

DCC:	119844442(HSPB1)

CPIC:

101932293(HSPB1)

TST:	117867659(HSPB1)

CABI:

116823472(HSPB1)

MRV:	120387600(HSPB1)

ASAO:

132763887(HSPB1)

PVT:	110085158(HSPB1)

SUND:

121916833(HSPB1)

PBI:	103056613 103059106

PMUR:

107294601(HSPB1)

CTIG:

120304263(HSPB1)

TSR:	106542810(HSPB1)

PGUT:

117667510(HSPB1)

APRI:

131188835(HSPB1)

PTEX:

113441584(HSPB1)

NSS:	113415156(HSPB1)

VKO:	123036736(HSPB1)

PMUA:

114585704(HSPB1)

PRAF:

128403156(HSPB1)

ZVI:	118097183(HSPB1)

HCG:	128335983(HSPB1)

GJA:	107107708(HSPB1)

STOW:

125446085(HSPB1)

EMC:	129344735(HSPB1)

XLA:	447105(hspb1.S) 447107(hspb1.L)

XTR:	780278(hspb1)

NPR:	108799257(HSPB1)

RTEM:

120926707(HSPB1)

BBUF:

120995482(HSPB1)

BGAR:

122932939(HSPB1)

MUO:	115482649(HSPB1)

GSH:	117349420(HSPB1)

DRE:	368243(hspb1)

SRX:	107723340 107725127 107734358 107740946

SANH:

107654311 107667824 107691052 107693867

SGH:	107562193 107587387 107591466 107598307

CCAR:

109075469 109079942

CAUA:

113049353 113068050 113073440 113075367

CGIB:

127957815 128014874

PTET:

122346040(hspb1)

LROH:

127165438(hspb1)

OMC:	131541643(hspb1)

PPRM:

120469736(hspb15) 120471722(hspb1)

RKG:	130076204(hspb1)

MAMB:

125266299(hspb1) 125267091(hspb15)

CIDE:

127513115

CERY:

137034676(hspb1)

MASI:

127423651 127433442

TROS:

130568038(hspb1)

TDW:	130419694(hspb1)

MANU:

129439519(hspb1)

IPU:	108260309(hspb15) 108260422

IFU:	128603334(hspb15) 128603808(hspb1)

PHYP:

113531010(hspb1) 113531577

SMEO:

124379401(hspb1)

TFD:	113634114(hspb1) 113655159(hspb15)

TVC:	132840872(hspb15) 132841096(hspb1)

TRN:	134303153(hspb15) 134303474(hspb1)

AMEX:

103029863(hspb15) 103042520(hspb1) 103047689

CMAO:

118802425(hspb15) 118814768(hspb1) 118827189

EEE:	113577546(hspb1) 113583627

CHAR:

105892226 105896093(hspb1) 105911019

TRU:	101065778 101076686(hspb1)

TFS:	130538180(hspb1)

TNG:	GSTEN00016260G001 GSTEN00029064G001

LCO:	104928776(hspb1) 104934677

NCC:	104958911 104961495(hspb1)

TBEN:

117476832 117499663(hspb1)

CGOB:

115016796 115019289

PGEO:

117456080 117459046(hspb1)

GACU:

117538479(hspb1) 117558178

EMAC:

134868591 134872672(hspb1)

ELY:	117261863(hspb1) 117269977

EFO:	125898362(hspb1) 125905740

PLEP:

121953077(hspb1) 121959601

SLUC:

116035088 116058317(hspb1)

ECRA:

117955447(hspb1) 117959332

ESP:	116699944(hspb1)

PFLV:

114567102(hspb1) 114571305

GAT:	120822799(hspb1) 120832081

PPUG:

119215711(hspb1) 119227085

AFB:	129102295 129113633(hspb1)

CLUM:

117741003 117742708(hspb1)

PSWI:

130191999(hspb1) 130205786

MSAM:

119895871(hspb1) 119914382

SCHU:

122865644 122888263(hspb1)

CUD:	121518602(hspb1) 121525464

ALAT:

119030171 119031884(hspb1)

MZE:	101464631 101481376(hspb1)

ONL:	100705966 100706864(hspb1)

OAU:	116322492 116330771(hspb1)

OLA:

101166150

OML:

112162837

CSAI:

133454658 133459822(hspb1)

XMA:	102218792 102218819 102222172(hspb1)

XCO:	114149095 114152958(hspb1) 114154092

XHE:	116723858 116728165(hspb1)

PRET:

103469858 103473747 103476069(hspb1)

PFOR:

103142068(hspb1) 103149046

PLAI:

106947050(hspb1) 106963298

PMEI:

106904570 106918944(hspb1)

GAF:	122845242(hspb1) 122847171

PPRL:

129366674 129368446(hspb1)

CVG:	107090327(hspb1) 107091286 107091956 107103841

CTUL:

119785606(hspb1) 119789000

GMU:	124872781 124875937(hspb1)

NFU:	107373577 107387034(hspb1)

KMR:	108232616 108233801(hspb1)

ALIM:

106514413 106525425(hspb1)

NWH:	119420209(hspb1) 119424276

AOCE:

111567941(hspb1) 111583564

MCEP:

124996614 125021598(hspb1)

CSEM:

103390125 103395180(hspb1)

POV:	109626345 109628310(hspb1)

SSEN:

122758491 122779365(hspb1)

HHIP:

117772061 117774108(hspb1)

HSP:	118121821(hspb1) 118125928

PPLT:

128424991 128456938(hspb1)

SMAU:

118285113 118301154(hspb1)

LCF:	108879898 108893894

SDU:	111222268(hspb1) 111234199

SLAL:

111663958(hspb1) 111664767

XGL:	120803079(hspb1) 120806569

HCQ:	109525325 109531123(hspb1)

SSCV:

125982486

SBIA:

133491548(hspb1)

PEE:	133415615(hspb1)

PTAO:

133467071(hspb1)

BPEC:

110160637 110165063(hspb1)

MALB:

109967032(hspb1) 109970803

BSPL:

114866463 114869034(hspb1)

SJO:	128371829(hspb1) 128380381

SASA:

100196153(hspb1) 106567403 106568216 106603948

STRU:

115148438 115149195 115153902 115159407

OTW:	112219464 112239930 112258337 112259324

OMY:	100136601(hspb1) 100136697 110523745 110539130

OGO:	123999829 124000592 124029477 124048809

ONE:	115105394(hspb1) 115105841 115125046

OKI:	109868101 109878649 109892524 109893029

OKE:	118376682 118387685 118391010 118391712

SALP:

111961472 111980743 111980977 112067795 112070311 112080095

SNH:	120018547 120026118 120032670 120045029 120056804

CCLU:

121557520 121573815 121574092 121579139(hspb1) 121582365

ELS:	105014911 105027776(hspb1)

SFM:	108928139 108936146 108938306

PKI:	111849899 111854694(hspb1) 111859704

AANG:

118206426(si:dkey-1k23.3) 118209323 118212703 118235128(hspb1)

LOC:	102688129(hspb1) 102688740

PSPA:

121300124 121308008(hspb1)

ARUT:

117426970 117428083 117429340 117430658

PSEX:

120531409(hspb1)

LCM:	102362208(HSPB1)

CMK:	103180610 103182174(si:dkey-1k23.3)

RTP:	109929983(si:dkey-1k23.3) 125486164(hspb1)

CPLA:

122562753(si:dkey-1k23.3) 122564155(hspb1)

HOC:	132827469(si:dkey-1k23.3) 132830276(hspb1)

LERI:

129709296(si:dkey-1k23.3) 129710695(hspb1)

PMRN:

116936893(HSPB1)

LRJ:	133362982(HSPB1)

CIN:

SCLV:

SLIU:

PGW:

DMK:

EAF:	111710291 111718457

LSM:	121117582 121117834 121122250

PPOI:

119100509 119101740

DSV:	119461785 119465860

RSAN:

RMP:

SDM:

PMEO:

LOA:	LOAG_12701

BGT:	106057335 106063112 106074014

CRG:	105331471 105346578 117691913

SMM:	Smp_049240

ADF:

AMIL:

PDAM:

SPIS:

Reference

PMID:10383393

Authors

Rogalla T, Ehrnsperger M, Preville X, Kotlyarov A, Lutsch G, Ducasse C, Paul C, Wieske M, Arrigo AP, Buchner J, Gaestel M

Title

Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation.

Journal

J Biol Chem 274:18947-56 (1999)
DOI:10.1074/jbc.274.27.18947

Sequence

[hsa:3315]

Reference

PMID:22521623

Authors

Acunzo J, Katsogiannou M, Rocchi P

Title

Small heat shock proteins HSP27 (HspB1), alphaB-crystallin (HspB5) and HSP22 (HspB8) as regulators of cell death.

Journal

Int J Biochem Cell Biol 44:1622-31 (2012)
DOI:10.1016/j.biocel.2012.04.002

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (2)   
   KEGG DISEASE (2)   
Gene (1045)   
   KEGG GENES (552)   
   KEGG MGENES (17)   
   RefGene (474)   
   OC (2)   
Literature (2)   
   PubMed (2)   
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