KEGG ORTHOLOGY: K04462

ORTHOLOGY: K04462

Entry

K04462                      KO

Symbol

MECOM, EVI1, PRDM3

Name

[histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein) [EC:2.1.1.367]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

map04010

MAPK signaling pathway

map05200

Pathways in cancer

map05220

Chronic myeloid leukemia

Reaction

R03875

Disease

H00004

Chronic myeloid leukemia

H00867

Radioulnar synostosis with amegakaryocytic thrombocytopenia

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K04462  MECOM, EVI1, PRDM3; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein)
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04462  MECOM, EVI1, PRDM3; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04462  MECOM, EVI1, PRDM3; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein)
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    K04462  MECOM, EVI1, PRDM3; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04462  MECOM, EVI1, PRDM3; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein)
   03036 Chromosome and associated proteins
    K04462  MECOM, EVI1, PRDM3; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein)
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.367  [histone H3]-lysine9 N-methyltransferase
     K04462  MECOM, EVI1, PRDM3; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein)
Transcription factors [BR:ko03000]
Eukaryotic type
  Zinc finger
   Cys2His2 PRDM
    K04462  MECOM, EVI1, PRDM3; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein)
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K04462  MECOM, EVI1, PRDM3; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein)

Other DBs

GO:

0046974

Genes

HSA:	2122(MECOM)

PTR:	460837(MECOM)

PPS:	100994741(MECOM)

GGO:	101143561(MECOM)

PON:	100431606(MECOM)

PPYG:

129033640(MECOM)

NLE:	100591579(MECOM)

HMH:	116481217(MECOM)

SSYN:

134733049(MECOM)

MCC:	698603(MECOM)

MCF:	102139452(MECOM)

MTHB:

126948321

MNI:	105466009(MECOM)

CSAB:

103221284(MECOM)

CATY:

105586041(MECOM)

PANU:

101001831(MECOM)

TGE:	112618964(MECOM)

MLEU:

105549705(MECOM)

RRO:	104677766(MECOM)

RBB:	108516319(MECOM)

TFN:	117083696(MECOM)

PTEH:

111543501(MECOM)

CANG:

105516737(MECOM)

CJC:	100403987(MECOM)

SBQ:	101051357(MECOM)

CIMI:

108285007(MECOM)

ANAN:

105729973(MECOM)

CSYR:

103274037(MECOM)

MMUR:

105879179(MECOM)

LCAT:

123630238(MECOM)

PCOQ:

105806970(MECOM)

OGA:	100951161(MECOM)

MMU:	14013(Mecom)

MCAL:

110290693(Mecom)

MPAH:

110319807(Mecom)

RNO:	294924(Mecom)

MCOC:

116095046(Mecom)

MUN:	110545680(Mecom)

CGE:	100768628(Mecom)

MAUA:

101844454(Mecom)

PROB:

127223342(Mecom)

PLEU:

114695325(Mecom)

MORG:

121452670(Mecom)

MFOT:

126499290

AAMP:

119826790(Mecom)

NGI:	103731713(Mecom)

HGL:	101718355(Mecom)

CPOC:

100727638(Mecom)

CCAN:

109700158(Mecom)

DORD:

105985625(Mecom)

DSP:	122107242(Mecom)

PLOP:

125351997(Mecom)

NCAR:

124992923

MMMA:

107149498(Mecom)

OCU:

100343228

OPI:	101517451(MECOM)

TUP:	102488385(MECOM)

GVR:	103587514(MECOM)

CFA:	488148(MECOM)

CLUD:

112645928(MECOM)

VVP:	112926657(MECOM)

VLG:	121477369(MECOM)

NPO:	129498810(MECOM)

AML:	100482997(MECOM)

UMR:	103680825(MECOM)

UAH:	113255350(MECOM)

UAR:	123786368(MECOM)

ELK:

111148284

LLV:

125100039

MPUF:

101684534(MECOM)

MNP:	132012065(MECOM)

MLK:	131824888(MECOM)

NVS:	122908678(MECOM)

ORO:	101384287(MECOM)

EJU:	114209093(MECOM)

ZCA:	113916913(MECOM)

MLX:	118006026(MECOM)

NSU:	110591643(MECOM)

LWW:

102740953

FCA:	101088775(MECOM)

PYU:	121033966(MECOM)

PCOO:

112850489(MECOM)

PBG:	122491755(MECOM)

PVIV:

125174966(MECOM)

LRUF:

124526640

PTG:	102955865(MECOM)

PPAD:

109262104(MECOM)

PUC:

125921882

AJU:

106990036

HHV:	120234625(MECOM)

BTA:	532209(MECOM)

BOM:	102288339(MECOM)

BIU:	109558403(MECOM)

BBUB:

102404893(MECOM)

BBIS:

104985176(MECOM)

CHX:	102182261(MECOM)

OAS:	101121055(MECOM)

BTAX:

128045496(MECOM)

ODA:	120869247(MECOM)

CCAD:

122444956(MECOM)

MBEZ:

129545711(MECOM)

SSC:	100518275(MECOM)

CFR:	102519252(MECOM)

CBAI:

105066680(MECOM)

CDK:	105085966(MECOM)

VPC:	102545172(MECOM)

BACU:

103008158(MECOM)

BMUS:

118894722(MECOM)

LVE:	103078502(MECOM)

OOR:	101289893(MECOM)

DLE:	111174247(MECOM)

PCAD:

102976185(MECOM)

PSIU:

116752976(MECOM)

NASI:

112404937(MECOM)

ECB:	100057450(MECOM)

EPZ:	103558280(MECOM)

EAI:	106834666(MECOM)

MYB:	102249519(MECOM)

MYD:	102766636(MECOM)

MMYO:

118676683(MECOM)

MLF:	102424289(MECOM)

MDT:	132230085(MECOM)

PKL:	118723215(MECOM)

EFUS:

103286715(MECOM)

MNA:	107539280(MECOM)

DRO:	112307202(MECOM)

SHON:

118987426(MECOM)

AJM:	119043606(MECOM)

PDIC:

114490488(MECOM)

PHAS:

123826822(MECOM)

MMF:	118617285(MECOM)

PPAM:

129076179(MECOM)

HAI:	109383470(MECOM)

RFQ:	117037203(MECOM)

PALE:

102878481(MECOM)

PGIG:

120598778(MECOM)

PVP:	105305980(MECOM)

RAY:	107512516(MECOM)

MJV:	108404714(MECOM)

TOD:	119257641(MECOM)

SARA:

101556018(MECOM)

SETR:

126010834 126011772

LAV:	100664202(MECOM)

TMU:

101350664

ETF:	101650652(MECOM)

DNM:	101438899(MECOM)

MDO:	100012479(MECOM)

GAS:	123242827(MECOM)

SHR:	100928711(MECOM)

AFZ:

127552855

PCW:	110203730(MECOM)

TVP:	118848787(MECOM)

OAA:	100084365(MECOM)

GGA:	424997(MECOM)

PCOC:

116243427(MECOM)

MGP:	100541414(MECOM)

CJO:	107318330(MECOM)

TPAI:

128082674(MECOM)

LMUT:

125697532(MECOM)

NMEL:

110398567(MECOM)

APLA:

101793295(MECOM)

ACYG:

106031974(MECOM)

CATA:

118253106(MECOM)

AFUL:

116492753(MECOM)

TGU:	100230662(MECOM)

LSR:	110480337(MECOM)

SCAN:

103815279(MECOM)

PMOA:

120504251(MECOM)

OTC:	121336547(MECOM)

PRUF:

121353723(MECOM)

GFR:	102039580(MECOM)

FAB:	101806754(MECOM)

OMA:	130256699(MECOM)

PHI:	102104707(MECOM)

PMAJ:

107208729(MECOM)

CCAE:

111933313(MECOM)

CCW:	104688053(MECOM)

CBRC:

103625072(MECOM)

ZAB:	102063184(MECOM)

ZLE:	135451697(MECOM)

ACHL:

103804100(MECOM)

SVG:	106859635(MECOM)

MMEA:

130580755(MECOM)

HRT:	120757039(MECOM)

SATI:

136365347(MECOM)

FPG:	101924233(MECOM)

FCH:	102055141(MECOM)

CCRI:

104158944(MECOM)

NNT:	104402745(MECOM)

SHAB:

115611686(MECOM) 115611687

ACUN:

113483543(MECOM)

TALA:

104365039(MECOM)

ACHC:

115347508(MECOM)

HALD:

104321016(MECOM)

HLE:	104835074(MECOM)

AGEN:

126039581

GCL:

127020044

CSTI:

104551300(MECOM)

LDI:	104343033(MECOM)

MNB:	103776675(MECOM)

DPUB:

104301922

AVIT:

104271549(MECOM)

BRHI:

104494577(MECOM)

EGZ:	104132485(MECOM)

NNI:	104022029(MECOM)

PCAO:

104051221

PADL:

103924951(MECOM)

AFOR:

103899975(MECOM)

FGA:	104079897(MECOM)

GSTE:

104256885(MECOM)

CLV:	102089407(MECOM)

MUI:	104534696(MECOM)

PGUU:

104467130(MECOM)

PLET:

104623847(MECOM)

EHS:	104506195(MECOM)

CMAC:

104482501(MECOM)

CUCA:

104062508(MECOM)

TEO:	104375132(MECOM)

BREG:

104638097(MECOM)

OHA:	104334394(MECOM)

ACAR:

104520704(MECOM)

CPEA:

104396836(MECOM)

CVF:	104285912(MECOM)

RTD:	128910758(MECOM)

AAM:

106486591

AROW:

112963835(MECOM)

NPD:	112952459(MECOM)

TGT:	104571520(MECOM)

DNE:	112986427(MECOM)

SCAM:

104143307(MECOM)

ASN:	102388244(MECOM)

AMJ:	102561786(MECOM)

CPOO:

109308413(MECOM)

GGN:	109287956(MECOM)

PSS:	102446951(MECOM)

CMY:	102944134(MECOM)

CCAY:

125642792(MECOM)

DCC:	119861367(MECOM)

CPIC:

101944916(MECOM)

TST:	117883099(MECOM)

CABI:

116822706(MECOM)

MRV:	120372281(MECOM)

ACS:	100555060(mecom)

ASAO:

132770523(MECOM)

PVT:	110085535(MECOM)

SUND:

121926171(MECOM)

PBI:	103065321(MECOM)

PMUR:

107292215(MECOM)

CTIG:

120305498(MECOM)

TSR:	106556923(MECOM)

PGUT:

117678211(MECOM)

APRI:

131200876(MECOM)

PTEX:

113439707 113439788(MECOM)

NSS:	113411115(MECOM) 113411805

VKO:	123025609(MECOM)

PMUA:

114597957(MECOM)

PRAF:

128414746(MECOM)

ZVI:	118093525(MECOM)

HCG:	128351199(MECOM)

GJA:	107125967(MECOM)

STOW:

125438025(MECOM)

EMC:	129331943(MECOM)

XLA:	100301954(mecom.S) 734157(mecom.L)

XTR:	100496511(mecom)

NPR:	108788059(MECOM)

RTEM:

120936732(MECOM)

BBUF:

120997870(MECOM)

BGAR:

122934442(MECOM)

MUO:	115478640(MECOM)

GSH:	117366404(MECOM)

DRE:	497407(mecom)

SRX:	107730859 107752009

SANH:

107683385 107704745

SGH:	107582226 107587798

CCAR:

109103379 109103380

CAUA:

113058632 113078801 113114962

CGIB:

127972606 128028962

PTET:

122359151(mecom)

LROH:

127177158(mecom)

OMC:	131554413(mecom)

PPRM:

120469521

RKG:	130077922(mecom)

MAMB:

125248870(mecom)

CIDE:

127495479

CERY:

137004299(mecom)

MASI:

127422432 127430167

TROS:

130565101(mecom)

TDW:	130428395(mecom)

MANU:

129438345(mecom)

IPU:

108269179

IFU:	128621806(mecom)

PHYP:

113544589(mecom)

SMEO:

124394478(mecom)

TFD:	113648358(mecom)

TVC:	132858072(mecom)

TRN:	134334181(mecom)

AMEX:

103042447(mecom)

CMAO:

118798921(mecom)

EEE:	113568060(mecom)

CHAR:

105899625(mecom)

TRU:	101069476(mecom)

TFS:	130535119(mecom)

LCO:	104936038(mecom)

NCC:

104952759

TBEN:

117470072(mecom)

CGOB:

115017293(mecom)

PGEO:

117457863(mecom)

GACU:

117542301(mecom)

EMAC:

134880677(mecom)

ELY:	117259822(mecom)

EFO:	125888762(mecom)

PLEP:

121943517(mecom)

SLUC:

116045529(mecom)

ECRA:

117940932(mecom)

ESP:	116678806(mecom)

PFLV:

114553079(mecom)

GAT:	120823708(mecom)

PPUG:

119215775(mecom)

AFB:	129092079(mecom)

CLUM:

117741316(mecom)

MSAM:

119883057(mecom)

SCHU:

122878911(mecom)

CUD:	121520079(mecom)

ALAT:

119012450(mecom)

MZE:	101468114(mecom)

ONL:

100699103

OAU:	116330361(mecom)

OLA:	101169474(mecom)

OML:	112149673(mecom)

CSAI:

133441639(mecom)

XMA:	102224242(mecom)

XCO:	114133278(mecom)

XHE:	116707997(mecom)

PRET:

103474425(mecom)

PFOR:

103152917(mecom)

PLAI:

106945686(mecom)

PMEI:

106922470(mecom)

GAF:	122832390(mecom)

PPRL:

129359178(mecom)

CVG:	107094210(mecom)

CTUL:

119775271(mecom)

GMU:	124883767(mecom)

NFU:	107380509(mecom)

KMR:	108240489(mecom)

ALIM:

106523993(mecom)

NWH:	119410524(mecom)

AOCE:

111573022(mecom)

MCEP:

125013663(mecom)

CSEM:

103377560(mecom)

POV:	109634633(mecom)

SSEN:

122773299(mecom)

HHIP:

117772924(mecom)

HSP:	118106548(mecom)

PPLT:

128440686(mecom)

SMAU:

118298899(mecom)

LCF:

108886333

SDU:	111224094(mecom)

SLAL:

111649993(mecom)

XGL:	120792306(mecom)

HCQ:	109525487(mecom)

SSCV:

125971781

SBIA:

133504313(mecom)

PEE:	133405387(mecom)

PTAO:

133481964(mecom)

BPEC:

110174294(mecom)

MALB:

109960327(mecom)

BSPL:

114868635(mecom)

SJO:	128360595(mecom)

SASA:

106580920 106612562

STRU:

115163229 115206170

OTW:	112265381 112267385

OMY:	110503751 110507082

OGO:	123992868 124006191

ONE:	115136895 115141695

OKI:	109905594 109909385

OKE:	118371328 127931225

SALP:

111949772 111982777

SNH:	120018783 120028738

CCLU:

121564826 121567563

ELS:	105024028(mecom)

SFM:	108922168(mecom)

PKI:	111834017(mecom)

AANG:

118209957(mecom)

LOC:	102695548(mecom)

PSPA:

121322874 121326704

ARUT:

117417159 117423468

PSEX:

120532998(mecom)

LCM:	102358043(MECOM)

CMK:	103180852(mecom)

RTP:	109921280(mecom)

CPLA:

122556249(mecom)

HOC:	132821741(mecom) 132821742

LERI:

PMRN:

LRJ:

BFO:

BBEL:

SPU:

APLC:

ARUN:

AJC:

SKO:

DME:	Dmel_CG31753(ham)

DER:

6549240

DSE:

6614589

DSI:	Dsimw501_GD21809(Dsim_GD21809)

DYA:	Dyak_GE12705

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI18122

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:	101890702 131805510

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ012100

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_200421

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

ATRA:

GMW:

PXY:

LGLY:

API:

DNX:

RMD:

BTAB:

DCI:	103512025 103523811

CLEC:

106665084

HHAL:

106689181

NLU:

111046016

PHU:	Phum_PHUM496070

TPAL:

ZNE:

CSEC:

BROR:

FCD:

DPX:	DAPPUDRAFT_113201(HAM)

DMK:	116915368 123469617

DPZ:

PVM:

PJA:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

VDE:

VJA:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

PCAN:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MMER:

RPHI:

DPOL:

MAEA:

LJP:

LAK:

LLON:

Reference

PMID:10867128

Authors

Jolkowska J, Witt M

Title

The EVI-1 gene--its role in pathogenesis of human leukemias.

Journal

Leuk Res 24:553-8 (2000)
DOI:10.1016/S0145-2126(00)00031-X

Sequence

[mmu:14013]

Reference

PMID:22939622

Authors

Pinheiro I, Margueron R, Shukeir N, Eisold M, Fritzsch C, Richter FM, Mittler G, Genoud C, Goyama S, Kurokawa M, Son J, Reinberg D, Lachner M, Jenuwein T

Title

Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity.

Journal

Cell 150:948-60 (2012)
DOI:10.1016/j.cell.2012.06.048

ORTHOLOGY: K08367

Entry

K08367                      KO

Symbol

RUNX1, AML1

Name

runt-related transcription factor 1

Pathway

map04530

Tight junction

map04659

Th17 cell differentiation

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05220

Chronic myeloid leukemia

map05221

Acute myeloid leukemia

Disease

H00001

B-cell acute lymphoblastic leukemia

H00003

Acute myeloid leukemia

H00004

Chronic myeloid leukemia

H00978

Thrombocytopenia (THC)

H02410

Myelodysplastic/myeloproliferative neoplasms

H02411

Chronic myelomonocytic leukemia

H02412

Atypical chronic myeloid leukemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K08367  RUNX1, AML1; runt-related transcription factor 1
09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K08367  RUNX1, AML1; runt-related transcription factor 1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08367  RUNX1, AML1; runt-related transcription factor 1
   05202 Transcriptional misregulation in cancer
    K08367  RUNX1, AML1; runt-related transcription factor 1
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K08367  RUNX1, AML1; runt-related transcription factor 1
   05220 Chronic myeloid leukemia
    K08367  RUNX1, AML1; runt-related transcription factor 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K08367  RUNX1, AML1; runt-related transcription factor 1
Transcription factors [BR:ko03000]
Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   Runt
    K08367  RUNX1, AML1; runt-related transcription factor 1

Genes

HSA:	861(RUNX1)

PTR:	101058316(RUNX1)

PPS:	100985479(RUNX1)

GGO:	101124359(RUNX1)

PON:	100449725(RUNX1)

PPYG:

129022570(RUNX1)

NLE:	100594110(RUNX1)

HMH:	116481760(RUNX1)

SSYN:

129482962(RUNX1)

MCC:	696749(RUNX1)

MCF:	102145008(RUNX1)

MTHB:

126950720

MNI:	105472675(RUNX1)

CSAB:

103218488(RUNX1)

CATY:

105575404(RUNX1)

PANU:

101020650(RUNX1)

TGE:	112620453(RUNX1)

MLEU:

105553168(RUNX1)

RRO:	104658772(RUNX1)

RBB:	108536870(RUNX1)

TFN:	117095741(RUNX1)

PTEH:

111525572(RUNX1)

CANG:

105517495(RUNX1)

CJC:	100385071(RUNX1)

SBQ:	101047789(RUNX1)

CIMI:

108302545(RUNX1)

ANAN:

105712668(RUNX1)

CSYR:

103276661(RUNX1)

MMUR:

105881312(RUNX1)

LCAT:

123630713(RUNX1)

PCOQ:

105824396(RUNX1)

OGA:	100940749(RUNX1)

MMU:	12394(Runx1)

MCAL:

110311558(Runx1)

MPAH:

110329713(Runx1)

RNO:	50662(Runx1)

MCOC:

116086157(Runx1)

ANU:	117717806(Runx1)

MUN:	110542151(Runx1)

CGE:	100758283(Runx1)

MAUA:

101825482(Runx1)

PROB:

127227534(Runx1)

PLEU:

114698416(Runx1)

MORG:

121461825(Runx1)

MFOT:

126515255

AAMP:

119824910(Runx1)

NGI:	103736431(Runx1)

HGL:	101705852(Runx1)

CPOC:

100724149(Runx1)

CCAN:

109700411(Runx1)

DORD:

105994104(Runx1)

DSP:	122114233(Runx1)

PLOP:

125351473(Runx1)

NCAR:

124992488

MMMA:

107136457(Runx1)

OCU:

100358993

OPI:	101527002(RUNX1)

TUP:	102496134(RUNX1)

GVR:	103586963(RUNX1)

CFA:	487746(RUNX1)

CLUD:

112661562(RUNX1)

VVP:	112910264(RUNX1)

VLG:	121479549(RUNX1)

NPO:	129502033(RUNX1)

AML:	100484679(RUNX1)

UMR:	103673224(RUNX1)

UAH:	113262125(RUNX1)

UAR:	123784224(RUNX1)

ELK:

111155817

LLV:

125094779

MPUF:

101682300(RUNX1)

MNP:	132012376(RUNX1)

MLK:	131825345(RUNX1)

NVS:	122908311(RUNX1)

ORO:	101367976(RUNX1)

EJU:	114218980(RUNX1)

ZCA:	113916631(RUNX1)

MLX:	118018850(RUNX1)

NSU:	110570078(RUNX1)

LWW:	102742597(RUNX1)

FCA:	101084898(RUNX1)

PYU:	121036458(RUNX1)

PCOO:

112849752(RUNX1)

PBG:	122491197(RUNX1)

PVIV:

125175497(RUNX1)

LRUF:

124526329

PPAD:

109249750(RUNX1)

PUC:

125921695

AJU:

106966472

HHV:	120229403(RUNX1)

BTA:	529631(RUNX1)

BOM:	102282115(RUNX1)

BIU:	109561422(RUNX1)

BBUB:

102392702(RUNX1)

BBIS:

104984993(RUNX1)

CHX:	102178020(RUNX1)

OAS:	101108280(RUNX1)

BTAX:

128067301(RUNX1)

ODA:	120880896(RUNX1)

CCAD:

122445458(RUNX1)

MBEZ:

129548990(RUNX1)

SSC:	100512633(RUNX1)

CFR:	102521748(RUNX1)

CBAI:

105070210(RUNX1)

CDK:	105089882(RUNX1)

VPC:	102539586(RUNX1)

BACU:

103006498(RUNX1)

BMUS:

118894572(RUNX1)

LVE:	103074813(RUNX1)

OOR:	101288785(RUNX1)

DLE:	111163859(RUNX1)

PCAD:

102984857(RUNX1)

PSIU:

116752916(RUNX1)

NASI:

112408651(RUNX1)

ECB:	100051950(RUNX1)

EPZ:	103549174(RUNX1)

EAI:	106832821(RUNX1)

MYB:	102247211(RUNX1)

MYD:	102768477(RUNX1)

MMYO:

118675205(RUNX1)

MLF:	102436751(RUNX1)

MDT:	132229853(RUNX1)

PKL:	118714829(RUNX1)

EFUS:

103289919(RUNX1)

MNA:	107533502(RUNX1)

DRO:	112305670(RUNX1)

SHON:

118983269(RUNX1)

AJM:	119035732(RUNX1)

PDIC:

114490064(RUNX1)

PHAS:

123827989(RUNX1)

MMF:	118616857(RUNX1)

PPAM:

129074356(RUNX1)

HAI:	109391240(RUNX1)

RFQ:	117034711(RUNX1)

PALE:

102879444(RUNX1)

PGIG:

120598670(RUNX1)

PVP:	105295829(RUNX1)

RAY:	107520364(RUNX1)

MJV:	108384793(RUNX1)

TOD:	119257211(RUNX1)

SARA:

101541108(RUNX1)

SETR:

126026065(RUNX1)

LAV:	100665882(RUNX1)

TMU:

101357079

ETF:	101662179(RUNX1)

DNM:	101443635(RUNX1)

MDO:	100025525(RUNX1)

GAS:	123242465(RUNX1)

SHR:	100921236(RUNX1)

AFZ:

127553849

PCW:	110214791(RUNX1)

TVP:	118839706(RUNX1)

OAA:	100082553(RUNX1)

GGA:	396152(RUNX1)

PCOC:

116241954(RUNX1)

MGP:	100540674(RUNX1)

CJO:	107323234(RUNX1)

TPAI:

128076371(RUNX1)

LMUT:

125699841(RUNX1)

NMEL:

110402700(RUNX1)

APLA:

101799657(RUNX1)

ACYG:

106043406(RUNX1)

CATA:

118247677(RUNX1)

AFUL:

116495487(RUNX1)

TGU:	100222588(RUNX1)

LSR:	110475368(RUNX1)

SCAN:

103815716 108961955

PMOA:

120502541(RUNX1)

OTC:	121334718(RUNX1)

PRUF:

121357999

GFR:

102042762

FAB:	101820379(RUNX1)

OMA:	130249704(RUNX1)

PHI:	102099092(RUNX1)

PMAJ:

107207834 107209383

CCAE:

111929229(RUNX1)

CCW:	104696772(RUNX1)

CBRC:

103617027(RUNX1)

ETL:	114071857 114072382

ACHL:

103807554(RUNX1)

SVG:	106863236(RUNX1)

HRT:	120749442(RUNX1)

SATI:

136358251

FPG:	101916329(RUNX1) 106112951

FCH:	102053520(RUNX1)

CCRI:

104169599(RUNX1)

SHAB:

115604604(RUNX1)

ACUN:

113478993(RUNX1)

TALA:

104361251(RUNX1)

ACHC:

115343870(RUNX1)

HLE:	104839819(RUNX1)

AGEN:

126053078

GCL:

127029605

DPUB:

104304940(RUNX1)

AVIT:

104277540(RUNX1)

EGZ:	104128174(RUNX1)

NNI:	104020181(RUNX1)

PCAO:

104048835(RUNX1)

PADL:

103920324(RUNX1)

AFOR:

103902076(RUNX1)

GSTE:

104263538

CLV:	102087117(RUNX1)

MUI:	104546970(RUNX1)

PGUU:

104466514(RUNX1)

PLET:

104616076

CMAC:

104475976(RUNX1)

CUCA:

104064743(RUNX1)

OHA:	104327770(RUNX1)

ACAR:

104520012

CPEA:

104391196(RUNX1)

CVF:	104292038(RUNX1)

RTD:	128919163(RUNX1)

AAM:	106494897(RUNX1)

AROW:

112971833(RUNX1)

NPD:	112948161(RUNX1)

TGT:

104573442

DNE:	112996178(RUNX1)

SCAM:

104139440(RUNX1)

ASN:	102385681(RUNX1)

AMJ:	102572910(RUNX1)

CPOO:

109305802(RUNX1)

GGN:	109302327(RUNX1)

PSS:	102455885(RUNX1)

CMY:	102944269(RUNX1)

CCAY:

125644031(RUNX1)

DCC:	119863355(RUNX1)

CPIC:

101938129(RUNX1)

TST:	117867441(RUNX1)

CABI:

116823670(RUNX1)

MRV:	120369420(RUNX1)

ACS:	100564051(runx1)

ASAO:

132771866(RUNX1)

PVT:	110076828(RUNX1)

SUND:

121927358(RUNX1)

PBI:	103055722(RUNX1)

PMUR:

107291521

CTIG:

120296644(RUNX1)

TSR:	106549617(RUNX1)

PGUT:

117678673(RUNX1)

APRI:

131199548(RUNX1)

PTEX:

113436250(RUNX1)

NSS:	113409898(RUNX1)

VKO:	123029379(RUNX1)

PMUA:

114596073(RUNX1)

PRAF:

128412997(RUNX1)

ZVI:	118084720(RUNX1)

HCG:	128351140(RUNX1)

GJA:

107117549

STOW:

125431869(RUNX1)

EMC:	129325931(RUNX1)

XLA:	108709238 379657(runx1.L)

XTR:	100485449(runx1)

NPR:	108791098(RUNX1)

RTEM:

120927927(RUNX1)

BBUF:

120994505(RUNX1)

BGAR:

122930826(RUNX1)

MUO:	115469485(RUNX1)

GSH:	117363083(RUNX1)

DRE:	58126(runx1)

SRX:	107709287(runx1) 107751097

SANH:

107653683 107698911

SGH:	107555250 107571884

CCAR:

109071062

CAUA:

113044609 113097601

CGIB:

127945896 127948782 128013330

PTET:

122349769(runx1)

LROH:

127171150(runx1)

OMC:	131530568(runx1)

PPRM:

120460533(runx1)

RKG:	130096670(runx1)

MAMB:

125272953(runx1)

CIDE:

127521140

CERY:

137031723(runx1)

MASI:

127443368 127445343

TROS:

130553126(runx1)

TDW:	130438776(runx1)

MANU:

129445107(runx1)

IPU:

108259037

IFU:	128602446(runx1)

PHYP:

113537666(runx1)

SMEO:

124378141(runx1)

TFD:	113648874(runx1)

TVC:	132839228(runx1)

TRN:	134328288(runx1)

AMEX:

103025657(runx1)

CMAO:

118798144(runx1)

EEE:

113582633

CHAR:

105889601(runx1)

TRU:	100049631(runx1)

TFS:	130522690(runx1)

TNG:	GSTEN00034595G001

LCO:

104936698

NCC:

104961881

TBEN:

117498938(runx1)

CGOB:

115018094

PGEO:

117458677(runx1)

GACU:

117546623(runx1)

EMAC:

134861146(runx1)

ELY:	117249915(runx1)

EFO:	125885173(runx1)

PLEP:

121964414

SLUC:

116036434(runx1)

ECRA:

117939492(runx1)

ESP:

116677658

PFLV:

114551073

GAT:	120821894(runx1)

PPUG:

119221892(runx1)

AFB:	129111552(runx1)

CLUM:

117746364(runx1)

PSWI:

130204236

MSAM:

119900649(runx1)

SCHU:

122872043(runx1)

CUD:	121506178(runx1)

ALAT:

119015595(runx1)

MZE:

101482179

ONL:

100691239

OAU:	116326998(runx1)

OLA:

101173202

OML:	112141993(runx1)

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122826911(runx1)

PPRL:

129356470(runx1)

CVG:

107098178

CTUL:

119779581(runx1)

GMU:	124861290(runx1)

NFU:

107384523

KMR:	108249382(runx1)

ALIM:

106534917

NWH:	119428785(runx1)

AOCE:

111562778

MCEP:

125000944(runx1)

CSEM:

103389730

POV:	109640042(runx1)

SSEN:

122765146(runx1)

HHIP:

117777362(runx1)

HSP:	118103459(runx1)

PPLT:

128430914(runx1)

SMAU:

118302323(runx1)

LCF:	108902563(runx1)

SDU:

111232758

SLAL:

111670267

XGL:	120798265(runx1)

HCQ:

109528744

SSCV:

125989217

SBIA:

133504475(runx1)

PEE:	133397843(runx1)

PTAO:

133482689(runx1)

BPEC:

110156597

MALB:

109952206

BSPL:

114848842(runx1)

SJO:	128354486(runx1)

SASA:

106574394 106575592 106595378

STRU:

115179193 115196293

OTW:	112267670(runx1) 121846747

OMY:	110495653 110527326

OGO:	124008497 124011043

ONE:

115129817

OKI:

109883367

OKE:	118363206 118379083

SNH:	120042747 120051428(runx1)

CCLU:

121543332(runx1)

ELS:	105019777(runx1)

SFM:	108931706 108938311(runx1)

PKI:	111856070(runx1)

AANG:

118214293(runx1) 118223562

LOC:	102682529(runx1)

PSPA:

121320993 121327982

ARUT:

117407217

PSEX:

120522828(runx1)

LCM:	102360635(RUNX1)

CMK:	103186755(runx1)

RTP:	109914103(runx1)

CPLA:

122554840(runx1)

HOC:	132821152(runx1)

LERI:

129702976(runx1)

PMRN:

116952997 116953354

LRJ:	133351276 133353458 133357060

BFO:

BBEL:

CIN:

SCLV:

SPU:	373468(SpRunt-1) 576197

APLC:

110978851

ARUN:

117296285

SKO:	100302713(runt)

LSQ:

ECOE:

AFLR:

VCAN:

AROA:

SOY:	115887579 115887589

CSET:

123317073 123317220 123317565

AGB:	108903535 108903536 108907089 111691513

LDC:

111512323

APLN:

108738268 108738269 108741870

PPYR:

116178939 116179797

OTU:	111416297 111419177

MSEX:

BANY:

PXU:

PRAP:

SLIU:

PGW:

CCRN:

AGS:

ACOO:

126835825 126841822 126841983

DVT:	126895183 126907234 126907774

DCI:

103516019

NLU:

120356734

HVI:	124362365 124362366

MQU:	128988728 128990133 128990979

IEL:

124171572

DMK:	116918153 116921892

CQD:

128702869

HAZT:

108676912

DFR:	124492668 124498985

ABRU:

129962580 129985350

UDV:	129224737 129225670 129225889

SDM:

118187943

PVUL:

126811682

BGT:

106059914

GAE:	121370556 121391817

HRF:

HRJ:

CRG:

CANU:

OED:

MMER:

DPOL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

RES:

TAD:	TRIADDRAFT_25179

AQU:

100638951

MPHI:

EG856_01160

» show all

Reference

PMID:1720541

Authors

Miyoshi H, Shimizu K, Kozu T, Maseki N, Kaneko Y, Ohki M

Title

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.

Journal

Proc Natl Acad Sci U S A 88:10431-4 (1991)
DOI:10.1073/pnas.88.23.10431

Sequence

[hsa:861]

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (12)   
   KEGG PATHWAY (12)   
Disease (7)   
   KEGG DISEASE (7)   
Gene (811)   
   KEGG GENES (500)   
   KEGG MGENES (116)   
   RefGene (194)   
   OC (1)   
Literature (1)   
   PubMed (1)   
All databases (833)   

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