KEGG ORTHOLOGY: K04463

ORTHOLOGY: K04463

Entry

K04463                      KO

Symbol

MAP2K5, MEK5

Name

mitogen-activated protein kinase kinase 5 [EC:2.7.12.2]

Pathway

map04010

MAPK signaling pathway

map04540

Gap junction

map04722

Neurotrophin signaling pathway

map04921

Oxytocin signaling pathway

map05418

Fluid shear stress and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04463  MAP2K5, MEK5; mitogen-activated protein kinase kinase 5
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K04463  MAP2K5, MEK5; mitogen-activated protein kinase kinase 5
09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K04463  MAP2K5, MEK5; mitogen-activated protein kinase kinase 5
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04463  MAP2K5, MEK5; mitogen-activated protein kinase kinase 5
09160 Human Diseases
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04463  MAP2K5, MEK5; mitogen-activated protein kinase kinase 5
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04463  MAP2K5, MEK5; mitogen-activated protein kinase kinase 5
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04463  MAP2K5, MEK5; mitogen-activated protein kinase kinase 5
Protein kinases [BR:ko01001]
Serine/threonine kinases: STE group
  STE7 family
   K04463  MAP2K5, MEK5; mitogen-activated protein kinase kinase 5

Other DBs

GO:

0004708

Genes

HSA:	5607(MAP2K5)

PTR:	453532(MAP2K5)

PPS:	100994910(MAP2K5)

GGO:	101137194(MAP2K5)

PON:	100449213(MAP2K5)

PPYG:

129014123(MAP2K5)

NLE:	100589848(MAP2K5)

HMH:	116482344(MAP2K5)

SSYN:

129482349(MAP2K5)

MCC:	711672(MAP2K5)

MCF:	102118759(MAP2K5)

MTHB:

126958153

MNI:	105488046(MAP2K5)

CSAB:

103245427(MAP2K5)

CATY:

105600975(MAP2K5)

PANU:

101017258(MAP2K5)

TGE:	112627876(MAP2K5)

MLEU:

105530907(MAP2K5)

RRO:	104662585(MAP2K5)

RBB:	108514696(MAP2K5)

TFN:	117070458(MAP2K5)

PTEH:

111548340(MAP2K5)

CANG:

105510517(MAP2K5)

CJC:	100395249(MAP2K5)

SBQ:	101037814(MAP2K5)

CIMI:

108296469(MAP2K5)

ANAN:

105716633(MAP2K5)

CSYR:

103267084(MAP2K5)

MMUR:

105873441(MAP2K5)

LCAT:

123631726(MAP2K5)

PCOQ:

105821419(MAP2K5)

OGA:	100963374(MAP2K5)

MMU:	23938(Map2k5)

MCAL:

110301925(Map2k5)

MPAH:

110327468(Map2k5)

RNO:	29568(Map2k5)

MCOC:

116072039(Map2k5)

ANU:	117699356(Map2k5)

MUN:	110550528(Map2k5)

CGE:	100760095(Map2k5)

MAUA:

101832805(Map2k5)

PROB:

127231866(Map2k5)

PLEU:

114691596(Map2k5)

MORG:

121465985(Map2k5)

MFOT:

126507420

AAMP:

119808775(Map2k5)

NGI:	103736811(Map2k5)

HGL:	101711080(Map2k5)

CPOC:

100732076(Map2k5)

CCAN:

109685304(Map2k5)

DORD:

105980914(Map2k5)

DSP:	122114577(Map2k5)

PLOP:

125340650(Map2k5)

NCAR:

124973399

MMMA:

107137987(Map2k5)

OCU:

100358715

OPI:	101519655(MAP2K5)

TUP:	102469877(MAP2K5)

GVR:

103598824

CFA:	609559(MAP2K5)

CLUD:

112675702(MAP2K5)

VVP:	112930203(MAP2K5)

VLG:	121485325(MAP2K5)

NPO:	129506245(MAP2K5)

AML:	100468286(MAP2K5)

UMR:	103679052(MAP2K5)

UAH:	113240899(MAP2K5)

UAR:	123800880(MAP2K5)

ELK:

111153163

LLV:

125103769

MPUF:

101676119(MAP2K5)

MNP:	131999552(MAP2K5)

MLK:	131835971(MAP2K5)

NVS:	122894224(MAP2K5)

ORO:	101383722(MAP2K5)

EJU:	114206368(MAP2K5)

ZCA:	113909636(MAP2K5)

MLX:	118003072(MAP2K5)

NSU:	110583815(MAP2K5)

LWW:	102740417(MAP2K5)

FCA:	101100725(MAP2K5)

PYU:	121041887(MAP2K5)

PCOO:

112855113(MAP2K5)

PBG:	122468470(MAP2K5)

PVIV:

125168331(MAP2K5)

LRUF:

124508459

PTG:	102949008(MAP2K5)

PPAD:

109262794(MAP2K5)

PUC:

125908910

AJU:

106980398

HHV:	120222273(MAP2K5)

BTA:	100295732(MAP2K5)

BOM:	102283668(MAP2K5)

BIU:	109564709(MAP2K5)

BBUB:

102392821(MAP2K5)

BBIS:

104984667(MAP2K5)

CHX:	102170427(MAP2K5)

OAS:	101104069(MAP2K5)

BTAX:

128053773(MAP2K5)

ODA:	120852514 120860892

CCAD:

122443078(MAP2K5)

MBEZ:

129563537(MAP2K5)

SSC:	106504229(MAP2K5)

CFR:	102517293(MAP2K5)

CBAI:

105069495(MAP2K5)

CDK:	105093278(MAP2K5)

VPC:	102532036(MAP2K5)

BACU:

103019868(MAP2K5)

BMUS:

118890559(MAP2K5)

LVE:	103088140(MAP2K5)

OOR:	101289255(MAP2K5)

DLE:	111177754(MAP2K5)

PCAD:

102983165 102995367(MAP2K5)

PSIU:

116748945(MAP2K5)

NASI:

112410870(MAP2K5)

ECB:	100052849(MAP2K5)

EPZ:	103561410(MAP2K5)

EAI:	106840611(MAP2K5)

MYB:	102260280(MAP2K5)

MYD:	102756005(MAP2K5)

MMYO:

118654369(MAP2K5)

MDT:	132235244(MAP2K5)

PKL:	118718897(MAP2K5)

EFUS:

103283781(MAP2K5)

MNA:	107525835(MAP2K5)

DRO:	112311249(MAP2K5)

SHON:

118992347(MAP2K5)

AJM:	119057046(MAP2K5)

PDIC:

114491548(MAP2K5)

PHAS:

123808725(MAP2K5)

MMF:	118632350(MAP2K5)

PPAM:

129064151(MAP2K5)

HAI:	109385248(MAP2K5)

RFQ:	117023572(MAP2K5)

PALE:

102894177(MAP2K5)

PGIG:

120604478(MAP2K5)

PVP:	105309698(MAP2K5)

RAY:	107508930(MAP2K5)

MJV:	108409326(MAP2K5)

TOD:	119238783(MAP2K5)

SARA:

101545900(MAP2K5)

SETR:

126021899(MAP2K5)

LAV:	100669040(MAP2K5)

TMU:

101345785

ETF:	101651393(MAP2K5)

DNM:	101429730(MAP2K5)

MDO:	100025486(MAP2K5)

GAS:	123238034(MAP2K5)

SHR:	100924259(MAP2K5)

AFZ:

127551231

PCW:	110205808(MAP2K5)

TVP:	118830089(MAP2K5)

OAA:	100085895(MAP2K5)

GGA:	415557(MAP2K5)

PCOC:

116225480(MAP2K5)

MGP:	100544509(MAP2K5)

CJO:	107318914(MAP2K5)

TPAI:

128075282(MAP2K5)

LMUT:

125698024(MAP2K5)

NMEL:

110403530(MAP2K5)

APLA:

101801808(MAP2K5)

ACYG:

106043660(MAP2K5)

CATA:

118259689(MAP2K5)

AFUL:

116493410(MAP2K5)

TGU:	100219724(MAP2K5)

LSR:	110480147(MAP2K5)

SCAN:

103816250(MAP2K5)

PMOA:

120508877(MAP2K5)

OTC:	121343470(MAP2K5)

PRUF:

121354451(MAP2K5)

GFR:	102032727(MAP2K5)

FAB:	101815546(MAP2K5)

OMA:	130257365(MAP2K5)

PHI:	102106364(MAP2K5)

PMAJ:

107209134(MAP2K5)

CCAE:

111933960(MAP2K5)

CCW:	104683873(MAP2K5)

CBRC:

103619866(MAP2K5)

ETL:	114065084(MAP2K5)

ZAB:	102064832(MAP2K5)

ZLE:	135452229(MAP2K5)

SVG:	106852124(MAP2K5)

MMEA:

130577124(MAP2K5)

HRT:	120758735(MAP2K5)

SATI:

136366821(MAP2K5)

FPG:	101924559(MAP2K5)

FCH:	102053857(MAP2K5)

CCRI:

104167608(MAP2K5)

NNT:	104408300(MAP2K5)

SHAB:

115612727(MAP2K5)

ACUN:

113483913(MAP2K5)

TALA:

104365805(MAP2K5)

ACHC:

115340931(MAP2K5)

HALD:

104325612(MAP2K5)

HLE:	104834619(MAP2K5)

AGEN:

126043595

GCL:

127020448

CSTI:

104555737(MAP2K5)

LDI:	104349007(MAP2K5)

MNB:	103777601(MAP2K5)

DPUB:

104303268(MAP2K5)

AVIT:

104278454(MAP2K5)

EGZ:	104125237(MAP2K5)

NNI:	104017044(MAP2K5)

PADL:

103914748(MAP2K5)

AFOR:

103899848(MAP2K5)

FGA:	104077790(MAP2K5)

CLV:	102095101(MAP2K5)

PLET:

104620678(MAP2K5)

EHS:	104513926(MAP2K5)

CMAC:

104485723(MAP2K5)

CUCA:

104065166(MAP2K5)

TEO:	104379585(MAP2K5)

BREG:

104641382(MAP2K5)

OHA:	104330707(MAP2K5)

ACAR:

104522545(MAP2K5)

CPEA:

104386650(MAP2K5)

CVF:	104288031(MAP2K5)

RTD:	128914550(MAP2K5)

AAM:	106494573(MAP2K5)

AROW:

112969945(MAP2K5)

NPD:	112948319(MAP2K5)

TGT:	104577050(MAP2K5)

DNE:	112996283(MAP2K5)

SCAM:

104139220(MAP2K5)

ASN:	102380357(MAP2K5)

AMJ:	102574038(MAP2K5)

CPOO:

109309206(MAP2K5)

GGN:	109288419(MAP2K5)

PSS:	102451373(MAP2K5)

CMY:	102946856(MAP2K5)

CCAY:

125643362(MAP2K5)

DCC:	119862666(MAP2K5)

CPIC:

101948796(MAP2K5)

TST:	117884537(MAP2K5)

CABI:

116815722(MAP2K5)

MRV:	120373331(MAP2K5)

ACS:	100562970(map2k5)

ASAO:

132762417(MAP2K5)

PVT:	110087994(MAP2K5)

SUND:

121934458(MAP2K5)

PBI:	103059198(MAP2K5)

PMUR:

107283916(MAP2K5)

CTIG:

120320150(MAP2K5)

TSR:	106538564(MAP2K5)

PGUT:

117676164(MAP2K5)

APRI:

131184903(MAP2K5)

PTEX:

113442010(MAP2K5)

NSS:	113415572(MAP2K5)

VKO:	123030697(MAP2K5)

PMUA:

114584990(MAP2K5)

PRAF:

128402206(MAP2K5)

ZVI:	118093285(MAP2K5)

HCG:	128334701(MAP2K5)

GJA:	107113289(MAP2K5)

STOW:

125424671(MAP2K5)

EMC:	129345464(MAP2K5)

XLA:	414694(map2k5.L)

XTR:	549042(map2k5)

NPR:	108784075(MAP2K5)

RTEM:

120931096(MAP2K5)

BBUF:

120986034(MAP2K5)

BGAR:

122927484(MAP2K5)

MUO:	115459945(MAP2K5)

GSH:	117348235(MAP2K5)

DRE:	100007679(map2k5)

SRX:

107755097

SANH:

107663978 107700484

SGH:	107563477(map2k5)

CCAR:

109046196 109093162(map2k5)

CAUA:

113106008(map2k5)

CGIB:

127961933

PTET:

122348777(map2k5)

LROH:

127168263(map2k5)

OMC:	131544102(map2k5)

PPRM:

120491035(map2k5)

RKG:	130099607(map2k5)

MAMB:

125264788(map2k5)

CIDE:

127515733

CERY:

137030431(map2k5)

MASI:

127416436 127449215

TROS:

130555647(map2k5)

TDW:	130418662(map2k5)

MANU:

129444036(map2k5)

IPU:

108259579

IFU:	128602709(map2k5)

PHYP:

113540896(map2k5)

SMEO:

124379918(map2k5)

TFD:	113636787(map2k5)

TVC:	132838771(map2k5)

TRN:	134304194(map2k5)

AMEX:

103027486(map2k5)

CMAO:

118817496(map2k5)

EEE:	113574092(map2k5)

CHAR:

105906492(map2k5)

TRU:	101078396(map2k5)

TFS:	130517450(map2k5)

TNG:	GSTEN00018103G001

LCO:	104927745(map2k5)

NCC:	104949852(map2k5)

TBEN:

117471174(map2k5)

CGOB:

115005674(map2k5)

PGEO:

117464794(map2k5)

GACU:

117549345(map2k5)

EMAC:

134863427(map2k5)

ELY:	117251390(map2k5)

EFO:	125902964(map2k5)

PLEP:

121946935(map2k5)

SLUC:

116043527(map2k5)

ECRA:

117948151(map2k5)

ESP:	116704058(map2k5)

PFLV:

114559002(map2k5)

GAT:	120812593(map2k5)

PPUG:

119198614(map2k5)

AFB:	129108444(map2k5)

CLUM:

117728633(map2k5)

PSWI:

130193272(map2k5)

MSAM:

119890174(map2k5)

SCHU:

122887014(map2k5)

CUD:	121507890(map2k5)

ALAT:

119018341(map2k5)

MZE:	101486139(map2k5)

ONL:	100696755(map2k5)

OAU:	116324026(map2k5)

OLA:	101169919(map2k5)

OML:	112160748(map2k5)

CSAI:

133459676(map2k5)

XMA:	102235643(map2k5)

XCO:	114143267(map2k5)

XHE:	116718814(map2k5)

PRET:

103462105(map2k5)

PFOR:

103146175(map2k5)

PLAI:

106959731(map2k5)

PMEI:

106924786(map2k5)

GAF:	122841676(map2k5)

PPRL:

129369543(map2k5)

CVG:	107097789(map2k5)

CTUL:

119799099(map2k5)

GMU:	124866462(map2k5)

NFU:	107381740(map2k5)

KMR:	108237850(map2k5)

ALIM:

106512959(map2k5)

NWH:	119430228(map2k5)

AOCE:

111568829(map2k5)

MCEP:

125005733(map2k5)

CSEM:

103379107(map2k5)

POV:	109637295(map2k5)

SSEN:

122772270(map2k5)

HHIP:

117756116(map2k5)

HSP:	118107267(map2k5)

PPLT:

128458966(map2k5)

SMAU:

118302140(map2k5)

LCF:

108887875

SDU:	111238645(map2k5)

SLAL:

111661161(map2k5)

XGL:	120794561(map2k5)

HCQ:	109514411(map2k5)

SSCV:

125967047

SBIA:

133498490(map2k5)

PEE:	133399164(map2k5)

PTAO:

133470969(map2k5)

BPEC:

110174525(map2k5)

MALB:

109963319(map2k5)

BSPL:

114852089(map2k5)

SJO:	128355767(map2k5)

STRU:

115166795(map2k5) 115183286

OTW:	112240758 121843558

OMY:	110526787 110526789

OGO:	124021038(map2k5)

OKI:	109876265 109886773

OKE:	127920187(map2k5)

SNH:	120024738 120024759

CCLU:

121571431(map2k5)

ELS:	105013604(map2k5)

SFM:	108934673(map2k5)

PKI:	111845610(map2k5)

AANG:

118227969(map2k5)

LOC:	102689860(map2k5)

PSPA:

121294693 121299180

ARUT:

117428339 117429614

PSEX:

120541660(map2k5)

LCM:	102357895(MAP2K5)

CMK:	103189582(map2k5)

RTP:	109929473(map2k5)

CPLA:

122540900(map2k5)

HOC:	132834274(map2k5)

LERI:

129712735(map2k5)

PMRN:

116939727(MAP2K5)

LRJ:	133346631(MAP2K5)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

ARUN:

AJC:

SKO:

HRO:	HELRODRAFT_107285

LGI:	LOTGIDRAFT_157785

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:	130639216 130642314

RES:

135687283

MBR:	MONBRDRAFT_16866

SRE:	PTSG_04499

» show all

Reference

PMID:7759517

Authors

Zhou G, Bao ZQ, Dixon JE

Title

Components of a new human protein kinase signal transduction pathway.

Journal

J Biol Chem 270:12665-9 (1995)
DOI:10.1074/jbc.270.21.12665

Sequence

[hsa:5607]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (10)   
   KEGG PATHWAY (10)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (760)   
   KEGG GENES (451)   
   KEGG MGENES (89)   
   RefGene (215)   
   OC (5)   
Literature (1)   
   PubMed (1)   
All databases (776)   

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