KEGG ORTHOLOGY: K04466

ORTHOLOGY: K04466

Entry

K04466                      KO

Symbol

MAP3K14, NIK

Name

mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]

Pathway

map04010

MAPK signaling pathway

map04064

NF-kappa B signaling pathway

map04210

Apoptosis

map04380

Osteoclast differentiation

map04625

C-type lectin receptor signaling pathway

map04660

T cell receptor signaling pathway

map04668

TNF signaling pathway

map04672

Intestinal immune network for IgA production

map04936

Alcoholic liver disease

map05120

Epithelial cell signaling in Helicobacter pylori infection

map05166

Human T-cell leukemia virus 1 infection

map05169

Epstein-Barr virus infection

map05208

Chemical carcinogenesis - reactive oxygen species

Disease

H00093

Combined immunodeficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
   04064 NF-kappa B signaling pathway
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
   04668 TNF signaling pathway
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
   04660 T cell receptor signaling pathway
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
   04672 Intestinal immune network for IgA production
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
   05169 Epstein-Barr virus infection
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
Protein kinases [BR:ko01001]
Serine/threonine kinases: STE group
  Other
   K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14

Other DBs

GO:

0004709

Genes

HSA:	9020(MAP3K14)

PTR:	454750(MAP3K14)

PPS:	100984930(MAP3K14)

GGO:	101147819(MAP3K14)

PON:	100436201(MAP3K14)

PPYG:

129018414(MAP3K14)

NLE:	100600394(MAP3K14)

HMH:	116474979(MAP3K14)

SSYN:

129470701(MAP3K14)

MCC:	716258(MAP3K14)

MCF:	102145584(MAP3K14)

MTHB:

126938709

MNI:	105468661(MAP3K14)

CSAB:

103243289(MAP3K14)

CATY:

105585587(MAP3K14)

PANU:

101024657(MAP3K14)

TGE:	112609983(MAP3K14)

MLEU:

105543832(MAP3K14)

RRO:	104678377(MAP3K14)

RBB:	108532216(MAP3K14)

TFN:	117066854(MAP3K14)

PTEH:

111525786(MAP3K14)

CANG:

105510391(MAP3K14)

CJC:	100401112(MAP3K14)

SBQ:	101044826(MAP3K14)

CIMI:

108318325(MAP3K14)

ANAN:

105711191(MAP3K14)

CSYR:

103262848(MAP3K14)

MMUR:

105883589(MAP3K14)

LCAT:

123621038(MAP3K14)

PCOQ:

105824147(MAP3K14)

OGA:	100957606(MAP3K14)

MMU:	53859(Map3k14)

MCAL:

110304892(Map3k14)

MPAH:

110332218(Map3k14)

RNO:	360640(Map3k14)

MCOC:

116079161(Map3k14)

ANU:	117711275(Map3k14)

MUN:	110545661(Map3k14)

CGE:	100766459(Map3k14)

MAUA:

101825130(Map3k14)

PROB:

127216792(Map3k14)

PLEU:

114702264(Map3k14)

MORG:

121436161(Map3k14)

MFOT:

126510438

AAMP:

119813599(Map3k14)

NGI:	103738320(Map3k14)

HGL:	101703313(Map3k14)

CPOC:

100719582(Map3k14)

CCAN:

109691665(Map3k14)

DORD:

105997576(Map3k14)

DSP:	122103419(Map3k14)

PLOP:

125365518(Map3k14)

NCAR:

124980247

MMMA:

107150497(Map3k14)

OCU:

100351032

OPI:	101516061(MAP3K14)

TUP:	102500729(MAP3K14)

GVR:	103595998(MAP3K14)

CFA:	490926(MAP3K14)

CLUD:

112655568(MAP3K14)

VVP:	112910639(MAP3K14)

VLG:	121473037(MAP3K14)

NPO:	129512996(MAP3K14)

AML:	100472260(MAP3K14)

UMR:	103665883(MAP3K14)

UAH:	113265323(MAP3K14)

UAR:	123802960(MAP3K14)

ELK:

111158123

LLV:

125086838

MPUF:

101688261(MAP3K14)

MNP:	132004586(MAP3K14)

MLK:	131817097(MAP3K14)

NVS:	122906116(MAP3K14)

ORO:	101363246(MAP3K14)

EJU:	114200618(MAP3K14)

ZCA:	113939264(MAP3K14)

MLX:	118024997(MAP3K14)

NSU:	110573171(MAP3K14)

LWW:	102734276(MAP3K14)

FCA:	101083468(MAP3K14)

PYU:	121045129(MAP3K14)

PCOO:

112854134(MAP3K14)

PBG:	122485712(MAP3K14)

PVIV:

125158420(MAP3K14)

LRUF:

124522088

PTG:	102964388(MAP3K14)

PPAD:

109258173(MAP3K14)

PUC:

125926656

AJU:

106988147

HHV:	120222278(MAP3K14)

BTA:	508367(MAP3K14)

BOM:	102268339(MAP3K14)

BIU:	109574056(MAP3K14)

BBUB:

102397755(MAP3K14)

BBIS:

104982962(MAP3K14)

CHX:	102189617(MAP3K14)

OAS:	101118799(MAP3K14)

BTAX:

128065013(MAP3K14)

ODA:	120866995(MAP3K14)

CCAD:

122440265(MAP3K14)

MBEZ:

129544511(MAP3K14)

SSC:	100520402(MAP3K14)

CFR:	102504523(MAP3K14)

CBAI:

105072525(MAP3K14)

CDK:	105094405(MAP3K14)

VPC:	102526769(MAP3K14)

BACU:

103015859(MAP3K14)

BMUS:

118887081(MAP3K14)

LVE:	103082490(MAP3K14)

OOR:	101270119(MAP3K14)

DLE:	111170190(MAP3K14)

PCAD:

102991269(MAP3K14)

PSIU:

116745052(MAP3K14)

NASI:

112410215(MAP3K14)

ECB:	100050140(MAP3K14)

EPZ:	103554685(MAP3K14)

EAI:	106836478(MAP3K14)

MYB:	102262247(MAP3K14)

MYD:	102762988(MAP3K14)

MMYO:

118671685(MAP3K14)

MLF:	102432497(MAP3K14)

MDT:	132218783(MAP3K14)

PKL:	118726383(MAP3K14)

EFUS:

103293009(MAP3K14)

MNA:	107528876(MAP3K14)

DRO:	112298609(MAP3K14)

SHON:

119001650(MAP3K14)

AJM:	119061562(MAP3K14)

PDIC:

114502860(MAP3K14)

PHAS:

123817083(MAP3K14)

MMF:	118634183(MAP3K14)

PPAM:

129086451(MAP3K14)

HAI:	109395015(MAP3K14)

RFQ:	117013869(MAP3K14)

PALE:

102897751(MAP3K14)

PGIG:

120589252(MAP3K14)

PVP:	105303461(MAP3K14)

RAY:	107508165(MAP3K14)

MJV:	108386996(MAP3K14)

TOD:	119230450(MAP3K14)

SARA:

101549152(MAP3K14)

SETR:

126016597(MAP3K14)

LAV:	100661927(MAP3K14)

TMU:

101343418

ETF:	101650553(MAP3K14)

DNM:	101428001(MAP3K14)

MDO:	100020668(MAP3K14)

GAS:	123243674(MAP3K14)

SHR:	100918124(MAP3K14)

AFZ:

127560369

PCW:	110215732(MAP3K14)

TVP:	118848555(MAP3K14)

OAA:	100085554(MAP3K14)

GGA:	419964(MAP3K14)

PCOC:

116233854(MAP3K14)

MGP:	100538760(MAP3K14)

CJO:	107325016(MAP3K14)

TPAI:

128088788(MAP3K14)

LMUT:

125684686(MAP3K14)

NMEL:

110388448(MAP3K14)

APLA:

101791236(MAP3K14)

ACYG:

106046936(MAP3K14)

CATA:

118258242(MAP3K14)

AFUL:

116498521(MAP3K14)

TGU:	100217837(MAP3K14)

LSR:	110475629(MAP3K14)

SCAN:

103821648(MAP3K14)

PMOA:

120498305(MAP3K14)

OTC:	121332978(MAP3K14)

PRUF:

121350568(MAP3K14)

GFR:	102038763(MAP3K14)

FAB:	101813386(MAP3K14)

OMA:	130264129(MAP3K14)

PHI:	102113463(MAP3K14)

PMAJ:

107215307(MAP3K14)

CCAE:

111940095(MAP3K14)

CCW:	104698524(MAP3K14)

CBRC:

103622666(MAP3K14)

ETL:	114068663(MAP3K14)

ZAB:	102071857(MAP3K14)

ZLE:	135458482(MAP3K14)

ACHL:

103811582(MAP3K14)

SVG:	106858264(MAP3K14)

MMEA:

130583662(MAP3K14)

HRT:	120763856(MAP3K14)

SATI:

136372238(MAP3K14)

FPG:	101919762(MAP3K14)

FCH:	102048630(MAP3K14)

CCRI:

104159125(MAP3K14)

NNT:	104402159(MAP3K14)

SHAB:

115617822(MAP3K14)

ACUN:

113489146(MAP3K14)

TALA:

104367810(MAP3K14)

ACHC:

115344910(MAP3K14)

HALD:

104310773(MAP3K14)

HLE:	104827955(MAP3K14)

AGEN:

126038780

GCL:

127026455

CSTI:

104554972(MAP3K14)

LDI:	104349714(MAP3K14)

MNB:	103774719(MAP3K14)

DPUB:

104300039(MAP3K14)

BRHI:

104495954(MAP3K14)

EGZ:	104132232(MAP3K14)

NNI:	104018900(MAP3K14)

PCRI:

104028095(MAP3K14)

PCAO:

104044905(MAP3K14)

PADL:

103921921(MAP3K14)

AFOR:

103906041(MAP3K14)

FGA:	104078879(MAP3K14)

GSTE:

104263875(MAP3K14)

CLV:	102088332(MAP3K14)

MUI:	104544021(MAP3K14)

PGUU:

104468872(MAP3K14)

PLET:

104623346(MAP3K14)

EHS:	104513073(MAP3K14)

CMAC:

104478148(MAP3K14)

CUCA:

104064883(MAP3K14)

TEO:	104382672(MAP3K14)

BREG:

104639373(MAP3K14)

OHA:	104333148(MAP3K14)

ACAR:

104532303(MAP3K14)

CPEA:

104387011(MAP3K14)

CVF:	104285288(MAP3K14)

RTD:	128919265(MAP3K14)

AAM:	106495649(MAP3K14)

AROW:

112971103(MAP3K14)

NPD:	112951091(MAP3K14)

TGT:	104578577(MAP3K14)

DNE:	112987825(MAP3K14)

SCAM:

104150857(MAP3K14)

ASN:	102388858(MAP3K14)

AMJ:	102575720(MAP3K14)

CPOO:

109323075(MAP3K14)

GGN:	109302060(MAP3K14)

PSS:	102464024(MAP3K14)

CMY:	102939834(MAP3K14)

CCAY:

125626604(MAP3K14)

DCC:	119849083(MAP3K14)

CPIC:

101932285(MAP3K14)

TST:	117869188(MAP3K14)

CABI:

116834675(MAP3K14)

MRV:	120385126(MAP3K14)

ACS:	100560190(map3k14)

ASAO:

132778327(MAP3K14)

PVT:	110081369(MAP3K14)

SUND:

121935260(MAP3K14)

PBI:	103066049(MAP3K14)

PMUR:

107303029(MAP3K14)

CTIG:

120302625(MAP3K14)

TSR:	106542520(MAP3K14)

PGUT:

117664727(MAP3K14)

APRI:

131197759(MAP3K14)

PTEX:

113447838(MAP3K14)

NSS:	113422085(MAP3K14)

VKO:	123031703(MAP3K14)

PMUA:

114581835(MAP3K14)

PRAF:

128399671(MAP3K14)

ZVI:	118094799(MAP3K14)

HCG:	128331536(MAP3K14)

GJA:	107125527(MAP3K14)

STOW:

125444265

EMC:	129338210(MAP3K14)

XLA:	108700848(map3k14.L) 108702551(map3k14.S)

XTR:	100489201(map3k14)

NPR:	108785983(MAP3K14)

RTEM:

120919584(MAP3K14)

BBUF:

121004595(MAP3K14)

BGAR:

122940347(MAP3K14)

MUO:	115481625(MAP3K14)

GSH:	117347767(MAP3K14)

DRE:	100004261(map3k14a) 795766

SRX:	107718093 107720017 107721479 107732105

SANH:

107654524 107667195 107674595 107677195

SGH:	107554607 107590367 107599747 107601304

CCAR:

109060827 109063225 109075409 109077428

CAUA:

113047004 113092744 113097181

CGIB:

127945919 127951501 127952266

PTET:

122329739 122341627(map3k14a)

LROH:

127155908 127162681(map3k14a)

OMC:	131532978 131536187(map3k14a)

PPRM:

120488026 120489596(map3k14a)

RKG:	130076070(map3k14a) 130084161

MAMB:

125258494 125272060(map3k14a)

CIDE:

127505789 127509022

CERY:

137014323 137017738(map3k14a)

MASI:

127434543 127450812 127451830

TROS:

130547116 130562096(map3k14a)

TDW:	130412833 130426820 130426833

MANU:

129426480 129433353(map3k14a)

IPU:	108259239(map3k14a) 108263809

IFU:	128602490(map3k14a) 128615878

PHYP:

113528261 113533797

SMEO:

124384893 124397147(map3k14a)

TFD:	113648526 113652180(map3k14a)

TVC:	132846352 132860710(map3k14a)

TRN:	134300116(map3k14a) 134310085

AMEX:

103043321(map3k14a) 103047161

CMAO:

118821145(map3k14a) 118822540

EEE:	113583770 113589915

CHAR:

105898527(map3k14a)

TRU:	101067596 101068369

TFS:	130514970(map3k14a) 130524869

TNG:	GSTEN00021996G001 GSTEN00022300G001

LCO:	104923921 104938682

NCC:	104944878 104964716

TBEN:

117473515 117493041(map3k14a)

CGOB:

115012791 115024164

PGEO:

117451148(map3k14a) 117464499

GACU:

117548791(map3k14a) 117553501

EMAC:

134870938 134878203(map3k14a)

ELY:	117246698 117268475(map3k14a)

EFO:	125879172(map3k14a) 125880629

PLEP:

121956795(map3k14a) 121959145

SLUC:

116059283(map3k14a) 116061531

ECRA:

117937009 117958471(map3k14a)

ESP:	116703189(map3k14)

PFLV:

114547852 114570367

GAT:	120818953 120827961(map3k14a)

PPUG:

119212464 119220116(map3k14a)

AFB:	129099022(map3k14a)

CLUM:

117734462(map3k14a) 117749129

PSWI:

130189187(map3k14a) 130204111

MSAM:

119891999(map3k14a) 119916377

SCHU:

122867963 122868362(map3k14a)

CUD:	121503832(map3k14a) 121528505

ALAT:

119009268 119014377(map3k14a)

MZE:	101468753 101468797

ONL:	100695488 100707432

OAU:	116312492(map3k14a) 120441419

OLA:	101166422 101174595

OML:	112145949(map3k14a) 112154182

CSAI:

133419520 133421363(map3k14a)

XMA:	102224137 102235269

XCO:	114151841 114160257

XHE:	116726678 116735806

PRET:

103468661 103481612

PFOR:

103142240 103151039

PLAI:

106938787(map3k14) 106953890

PMEI:

106917289 106925139

GAF:	122822000(map3k14a) 122822864

PPRL:

129352553(map3k14a) 129368276

CVG:	107084720 107093973

CTUL:

119776029 119778852(map3k14a)

GMU:	124862201 124863966 124874891

NFU:	107378477 107387294

KMR:	108246150(map3k14a)

ALIM:

106522002(map3k14) 106528348

NWH:	119421922(map3k14a) 119423565

AOCE:

111570768 111581683

MCEP:

124997473(map3k14a) 125021920

CSEM:

103381634 103392614

POV:	109633940 109645298

SSEN:

122760915 122780434 122785133 122785170

HHIP:

117752515 117766955(map3k14a)

HSP:	118100220 118123057(map3k14a)

PPLT:

128457985(map3k14a)

SMAU:

118286948 118288517(map3k14a)

LCF:	108892063 108900811(map3k14a)

SDU:	111217746 111219576

SLAL:

111660531 111664391

XGL:	120788413(map3k14a) 120794657

HCQ:	109518541 109519328

SSCV:

125983768

SBIA:

133496070 133514098(map3k14a)

PEE:	133414492(map3k14a) 133418292

PTAO:

133465930(map3k14a) 133469725

BPEC:

110168889

MALB:

109962735 109964259

BSPL:

114845633 114860603(map3k14a)

SJO:	128379174(map3k14a) 128381093

SASA:

100380862(m3k14) 106579033 106607326

STRU:

115158237 115171147 115198333

OTW:	112223536 112226021 112246048(map3k14a)

OMY:	110486292 110491468 110538227

OGO:	123999636 124015247 124047575

ONE:	115104159 115106439 115110305

OKI:	109865966 109893340 109893356

OKE:	118367281 118375729 118384507(map3k14a)

SALP:

111978338 111980803 112072746

SNH:	120034417 120036304

CCLU:

121549348 121550601 121569549

ELS:	105007974 105013210

SFM:	108928263 108941583

PKI:	111832882 111855960

AANG:

118216771 118221513

LOC:	102690698 107078787

PSPA:

121301894(map3k14a)

ARUT:

117427187 117433487(map3k14a)

PSEX:

120520062

LCM:	102351315(MAP3K14)

RTP:	109910938(map3k14a)

CPLA:

122540009(map3k14a)

HOC:	132830903(map3k14a)

LERI:

129710205(map3k14a)

BBEL:

CIN:

ATEN:

SPIS:

Reference

PMID:9020361

Authors

Malinin NL, Boldin MP, Kovalenko AV, Wallach D

Title

MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.

Journal

Nature 385:540-4 (1997)
DOI:10.1038/385540a0

Sequence

[hsa:9020]

Reference

PMID:15084608

Authors

Liao G, Zhang M, Harhaj EW, Sun SC

Title

Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation.

Journal

J Biol Chem 279:26243-50 (2004)
DOI:10.1074/jbc.M403286200

Sequence

[hsa:9020]

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Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (26)   
   KEGG PATHWAY (26)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (834)   
   KEGG GENES (537)   
   KEGG MGENES (204)   
   RefGene (91)   
   OC (2)   
Literature (2)   
   PubMed (2)   
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