KEGG   ORTHOLOGY: K04480
Entry
K04480                      KO                                     

Name
mtaB
Definition
methanol---5-hydroxybenzimidazolylcobamide Co-methyltransferase [EC:2.1.1.90]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K04480  mtaB; methanol---5-hydroxybenzimidazolylcobamide Co-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.90  methanol---corrinoid protein Co-methyltransferase
     K04480  mtaB; methanol---5-hydroxybenzimidazolylcobamide Co-methyltransferase
Other DBs
RN: R04384 R09098
GO: 0047152
Genes
DSX: GD604_09795
DTI: Desti_2034
CFM: BJL90_02615
CCL: Clocl_0783
ANR: Ana3638_17590
DKU: Desku_0051
TJR: TherJR_0987
DOR: Desor_2803
DMI: Desmer_2205
ELM: ELI_2003
EMT: CPZ25_002645
ELIM: B2M23_16850
AWO: Awo_c22760(mttB18)
MTA: Moth_1209
MTHO: MOTHE_c11860
MTHZ: MOTHA_c12720
TPZ: Tph_c03590(mtaB)
MANA: MAMMFC1_02497
STED: SPTER_30470
ALUS: STSP2_00335
MST: Msp_0184(mtaB3) Msp_0186(mtaB2) Msp_0188(mtaB1) Msp_0819(mtaB4)
METB: AW729_03460 AW729_06185
MSI: Msm_0515
MEL: Metbo_1023
MEW: MSWAN_1082
MCUB: MCBB_1154(mtaB)
MBA: Mbar_A0741 Mbar_A1064 Mbar_A3638
MBY: MSBRM_0302 MSBRM_2353 MSBRM_3321
MBW: MSBRW_0261 MSBRW_1094 MSBRW_3658
MBAR: MSBR2_2078 MSBR2_2319 MSBR2_3275
MBAK: MSBR3_2096 MSBR3_2380 MSBR3_3273
MAC: MA_0455(mtaB1) MA_1616(mtaB3) MA_4392(mtaB2)
MMA: MM_0175(mtaB) MM_1074(mtaB) MM_1647
MMAZ: MmTuc01_0182 MmTuc01_1725
MMJ: MSMAS_0227 MSMAS_1126 MSMAS_3023
MMAC: MSMAC_0233 MSMAC_1415 MSMAC_2486
MVC: MSVAZ_0210 MSVAZ_0343 MSVAZ_1365
MEK: MSKOL_0204 MSKOL_0326 MSKOL_1308
MLS: MSLAZ_0239 MSLAZ_1380 MSLAZ_2955
METM: MSMTP_0258 MSMTP_1140 MSMTP_2926
MEF: MSWH1_0315 MSWH1_0524 MSWH1_1022
MEQ: MSWHS_0318 MSWHS_0538 MSWHS_1093
MSJ: MSSAC_0405 MSSAC_1598 MSSAC_4075
MSZ: MSSIH_0373 MSSIH_1187 MSSIH_3611
MSW: MSSIT_0381 MSSIT_1254 MSSIT_3664
MTHR: MSTHT_0083 MSTHT_1750 MSTHT_2137
MTHE: MSTHC_0647 MSTHC_1146 MSTHC_1539
MHOR: MSHOH_0282 MSHOH_1348 MSHOH_3746
MFZ: AOB57_002020 AOB57_005220 AOB57_007940
MBU: Mbur_0812 Mbur_0814
MMET: MCMEM_0944 MCMEM_0947 MCMEM_0949
MMH: Mmah_0976 Mmah_0978
MHAZ: BHR79_08685 BHR79_08695
MEV: Metev_0944
MZH: Mzhil_1950 Mzhil_1952
MPY: Mpsy_0909 Mpsy_3036
MZI: HWN40_04050 HWN40_07075
MHZ: Metho_0775 Metho_1601
RCI: RCIX1974(mtaB)
MAX: MMALV_09470
MER: MMINT_02820 MMINT_03160 MMINT_05920
MEAR: Mpt1_c05090(mtaB)
MARC: AR505_0949 AR505_0951
 » show all
Reference
  Authors
Pritchett MA, Metcalf WW
  Title
Genetic, physiological and biochemical characterization of multiple methanol methyltransferase isozymes in Methanosarcina acetivorans C2A.
  Journal
Mol Microbiol 56:1183-94 (2005)
DOI:10.1111/j.1365-2958.2005.04616.x
  Sequence

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Ontology (3)   
   KEGG BRITE (2)   
   GO (1)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical reaction (7)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
   KEGG RCLASS (4)   
Gene (195)   
   KEGG GENES (124)   
   KEGG MGENES (43)   
   RefGene (27)   
   OC (1)   
Literature (1)   
   PubMed (1)   
All databases (215)   

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KEGG   ENZYME: 2.1.1.90
Entry
EC 2.1.1.90                 Enzyme                                 

Name
methanol---corrinoid protein Co-methyltransferase;
methanol cobalamin methyltransferase;
methanol:5-hydroxybenzimidazolylcobamide methyltransferase;
MT 1 (ambiguous);
methanol---5-hydroxybenzimidazolylcobamide Co-methyltransferase;
mtaB (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase
Reaction(IUBMB)
methanol + a [Co(I) methanol-specific corrinoid protein] = a [methyl-Co(III) methanol-specific corrinoid protein] + H2O [RN:R04384]
Reaction(KEGG)
R04384;
(other) R09098
Substrate
methanol [CPD:C00132];
[Co(I) methanol-specific corrinoid protein]
Product
[methyl-Co(III) methanol-specific corrinoid protein];
H2O [CPD:C00001]
Comment
The enzyme, which catalyses the transfer of methyl groups from methanol to a methanol-specific corrinoid protein (MtaC), is involved in methanogenesis from methanol. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. Free cob(I)alamin can substitute for the corrinoid protein in vitro [2].
Inactivated by oxygen and other oxidizing agents, and reactivated by catalytic amounts of ATP and hydrogen.
History
EC 2.1.1.90 created 1989, modified 2012
Pathway
ec00680  Methane metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K04480  methanol---5-hydroxybenzimidazolylcobamide Co-methyltransferase
Genes
DSX: GD604_09795
DTI: Desti_2034
CFM: BJL90_02615
CCL: Clocl_0783
ANR: Ana3638_17590
DKU: Desku_0051
TJR: TherJR_0987
DOR: Desor_2803
DMI: Desmer_2205
ELM: ELI_2003
EMT: CPZ25_002645
ELIM: B2M23_16850
AWO: Awo_c22760(mttB18)
MTA: Moth_1209
MTHO: MOTHE_c11860
MTHZ: MOTHA_c12720
TPZ: Tph_c03590(mtaB)
MANA: MAMMFC1_02497
STED: SPTER_30470
ALUS: STSP2_00335
MST: Msp_0184(mtaB3) Msp_0186(mtaB2) Msp_0188(mtaB1) Msp_0819(mtaB4)
METB: AW729_03460 AW729_06185
MSI: Msm_0515
MEL: Metbo_1023
MEW: MSWAN_1082
MCUB: MCBB_1154(mtaB)
MBA: Mbar_A0741 Mbar_A1064 Mbar_A3638
MBY: MSBRM_0302 MSBRM_2353 MSBRM_3321
MBW: MSBRW_0261 MSBRW_1094 MSBRW_3658
MBAR: MSBR2_2078 MSBR2_2319 MSBR2_3275
MBAK: MSBR3_2096 MSBR3_2380 MSBR3_3273
MAC: MA_0455(mtaB1) MA_1616(mtaB3) MA_4392(mtaB2)
MMA: MM_0175(mtaB) MM_1074(mtaB) MM_1647
MMAZ: MmTuc01_0182 MmTuc01_1725
MMJ: MSMAS_0227 MSMAS_1126 MSMAS_3023
MMAC: MSMAC_0233 MSMAC_1415 MSMAC_2486
MVC: MSVAZ_0210 MSVAZ_0343 MSVAZ_1365
MEK: MSKOL_0204 MSKOL_0326 MSKOL_1308
MLS: MSLAZ_0239 MSLAZ_1380 MSLAZ_2955
METM: MSMTP_0258 MSMTP_1140 MSMTP_2926
MEF: MSWH1_0315 MSWH1_0524 MSWH1_1022
MEQ: MSWHS_0318 MSWHS_0538 MSWHS_1093
MSJ: MSSAC_0405 MSSAC_1598 MSSAC_4075
MSZ: MSSIH_0373 MSSIH_1187 MSSIH_3611
MSW: MSSIT_0381 MSSIT_1254 MSSIT_3664
MTHR: MSTHT_0083 MSTHT_1750 MSTHT_2137
MTHE: MSTHC_0647 MSTHC_1146 MSTHC_1539
MHOR: MSHOH_0282 MSHOH_1348 MSHOH_3746
MFZ: AOB57_002020 AOB57_005220 AOB57_007940
MBU: Mbur_0812 Mbur_0814
MMET: MCMEM_0944 MCMEM_0947 MCMEM_0949
MMH: Mmah_0976 Mmah_0978
MHAZ: BHR79_08685 BHR79_08695
MEV: Metev_0944
MZH: Mzhil_1950 Mzhil_1952
MPY: Mpsy_0909 Mpsy_3036
MZI: HWN40_04050 HWN40_07075
MHZ: Metho_0775 Metho_1601
RCI: RCIX1974(mtaB)
MAX: MMALV_09470
MER: MMINT_02820 MMINT_03160 MMINT_05920
MEAR: Mpt1_c05090(mtaB)
MARC: AR505_0949 AR505_0951
 » show all
Reference
1  [PMID:6438059]
  Authors
van der Meijden P, te Brommelstroet BW, Poirot CM, van der Drift C, Vogels GD.
  Title
Purification and properties of methanol:5-hydroxybenzimidazolylcobamide methyltransferase from Methanosarcina barkeri.
  Journal
J Bacteriol 160:629-35 (1984)
DOI:10.1128/JB.160.2.629-635.1984
  Sequence
Reference
2  [PMID:10215883]
  Authors
Sauer K, Thauer RK
  Title
Methanol:coenzyme M methyltransferase from Methanosarcina barkeri -- substitution of the corrinoid harbouring subunit MtaC by free cob(I)alamin.
  Journal
Eur J Biochem 261:674-81 (1999)
DOI:10.1046/j.1432-1327.1999.00355.x
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.90
IUBMB Enzyme Nomenclature: 2.1.1.90
ExPASy - ENZYME nomenclature database: 2.1.1.90
BRENDA, the Enzyme Database: 2.1.1.90
CAS: 86611-98-5

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Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (6)   
   KEGG REACTION (2)   
   KEGG RCLASS (4)   
Gene (195)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (124)   
   KEGG MGENES (43)   
   RefGene (27)   
Protein sequence (38)   
   UniProt (18)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
   PDBSTR (16)   
DNA sequence (15)   
   RefSeq(nuc) (3)   
   GenBank (6)   
   EMBL (6)   
3D Structure (1)   
   PDB (1)   
Protein domain (1)   
   InterPro (1)   
All databases (267)   

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KEGG   REACTION: R09098
Entry
R09098                      Reaction                               

Name
methanol:coenzyme M methyltransferase
Definition
Methanol + Coenzyme M <=> 2-(Methylthio)ethanesulfonate + H2O
Equation
Comment
two-step reaction (see R04384+R10000)
Reaction class
RC00035  C03576_C03920
RC02440  C00132_C03920
Enzyme
2.1.1.90        2.1.1.246
Pathway
rn00680  Methane metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00356  Methanogenesis, methanol => methane
Orthology
K04480  methanol---5-hydroxybenzimidazolylcobamide Co-methyltransferase [EC:2.1.1.90]
K14080  [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase [EC:2.1.1.246]
K14081  methanol corrinoid protein

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (4)   
   KEGG ENZYME (2)   
   KEGG RCLASS (2)   
Gene (542)   
   KEGG ORTHOLOGY (3)   
   KEGG GENES (539)   
All databases (560)   

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